Here's the episode: [1]

I am not convinced Albert Most (the pseudonym of Ken Nelson[2]) was the first to use 5-MeO-DMT.

Most/Nelson published his pamphlet in 1983, while more than 10 years earlier 5-MeO-DMT was apparently used by the Church of the Tree of Life and sold by the Inner Center at Hermosa Beach:[3][4][5][6][7]

"The San Francisco-based Church of the Tree of Life aimed to be to the still-legal psychoactive substances what the Native American Church was for peyote. Incorporated in 1971 by life-extension expert John Mann, it existed largely as a legal entity to protect the use of the drugs mentioned in Legal Highs. If any of these materials became illegal, it was reasoned, a religious-use exemption for Church members could be grandfathered in with the new statutes, much as the peyote exemption had been for American Indians."

"One of the Church's prime sacramental sources was the Inner Center of Hermosa Beach. A popular item in its mail-order catalog was 5-MeO-DMT, a legal variant of the short-acting tryptamine DMT, which produced a brief yet powerful psychedelic trip. The chemical was sprayed onto parsley or oregano leaves, which would then be smoked like marijuana to produce an intense, almost otherworldly state."

According to [7]:

"...a 1973 booklet Legal Highs: A Concise Encyclopedia of Legal Herbs and Chemicals with Psychoactive Properties included 5-MeO-DMT, noting that "the Church of the Tree of Life has declared as its religious sacraments most substances in this book."

"Since the first scientific paper that publicized the fact that the Bufo Alvarius was a walking 5-MeO-DMT factory was not widely circulated until 1967, it is quite possible that smoking toad venom is a completely modern invention. It has also been pointed out to me that our modern civilization is probably the first one which has realized that it is possible to smoke DMT or 5-MeO-DMT - until this time we have either taken it as a snuff, a potion, or, most recently, injecting it. Whatever the case, the Legal Highs booklet in 1973 now listed the Karma Kem Ko. in Yatesboro, PA and Terrestrial Materials in San Francisco, CA as suppliers of 5-MeO-DMT.

"In a 1977 Head magazine article titled "DMT" authors Jeremy Bigwood and Jonathan Ott noted that 5-MeO-DMT "has been sold on the illicit market," they also commented that it was not a controlled substance. Nevertheless, Bigwood and Ott did little to promote the drug, when they quoted a description from M.V. Smith's 1976 book Psychedelic Chemistry that described the effects of 5-MeO-DMT as being similar to "having a large elephant sit on one's head," and they concluded by stating that they felt the drug "has little recreational value." (The exact quote from Smith is, "The effects of 5-methoxy-DMT are unpleasant for most people (smoking it gives me nausea plus the feeling that I'm being sat on by an elephant)" (Smith 1981).)*

"The 1978 High Times Encyclopedia of Recreational Drugs remarks that 5-MeO-DMT "has been synthesized and was occasionally available in the California underground market a few years ago. The effects are practically identical to laboratory DMT available in the 1960s."

So human use of 5-MeO-DMT seems to go back to at least the early 1970's, though it's not clear who its first user was. It would be great to interview all the different people and whoever ran the companies mentioned in the above quotes about this.

[1] - https://www.youtube.com/watch?v=xoE7u6mgS7E

[2] - https://www.psychedelictoadofthesonorandesert.com/preface

[3] - http://califias.blogspot.com/2014/11/the-church-of-tree-of-l...

[4] - https://en.wikipedia.org/wiki/Church_of_the_Tree_of_Life

[5] - https://journals.sagepub.com/doi/abs/10.1177/002204268801800...

[6] - http://www.textfiles.com/drugs/addresse

[7] - http://www.dmtsite.com/5-meo-dmt/information/modern_usage.ht...