skysight-inc/HackerNews huggingface dataset:
There's a ton of off-patent medicines. You can't do large-scale trials for all of them, there literally aren't enough COVID patients to do a large-scale trial for every off-patent medicine that exists. You have to have some selection criteria.

Ivermectin is an anti-parasite drug. It is not an anti-viral. There is no theory for a mechanism of action for why it would be effective against COVID. There is some laboratory evidence that Ivermectin at very high concentrations can inhibit replication of COVID-19 and other viruses. The problem with this is that extrapolating from those concentrations to a dosing regimen means a dose of Ivermectin far, far higher than the dosage of Ivermectin given in humans.

So, without sufficient evidence, there's no compelling reason to do a large trial of Ivermectin.
It might be a way to build awareness and goodwill, but they are burning VC capital to offer a service that is either fundamentally unsustainable or mispriced.

I'm clutching my pearls so hard after reading this, I may have uttered a "I do declare..." and wiped sweat from my brow as well. :)
I wish more technologists had this level of integrity.
This is spot on. As someone who has been looking for a data analyst role, I’ve actually read quite a few DS reqs that were geared more towards infrastructure and ETL. Then the flip side with the DE reqs wanting NumPy and Pandas along with the infrastructure and ETL. Weird, right?
long before there were convenient tools like xpra to move a window from one X terminal to another i was able to connect emacs to multiple X terminals at once, and in that way switch between computers and keep using the same instance of emacs via gui.

given that emacs works just as well in a terminal, that is not a huge advantage, but it is noteworthy that emacs has this capability and had it for a long time. something any gui program could have in theory
It's the simplest that "The Grand Unified Programming Theory: The Pure Function Pipeline Data Flow with Principle-based Warehouse/Workshop Model"

https://github.com/linpengcheng/PurefunctionPipelineDataflow
You are wrong, period. Watch the videos, read the studies. Your body’s ability to store fat is a function of insulin levels, that is as much a factor as calories.
They are still 95% effective after 6 months at preventing death. They are unknown effective against new variants. I've seen a variety of studies with different variants tested against Delta. At best I read 92% for Pfizer (but a previous test had them at 60%), other vaccines as low as 30%. The new variants like lambda have shown it responds to antibiotic poorly, it spreads quickly and is more deadly compared to delta. I'm not sure the vaccine strategy will continue to work.
I think Oracle would still have a bouquet of roses, but they'd only go to Larry Ellison.
I wonder where ISIS gets it's weapons? Surprise, it's from the ""defense"" companies.

https://www.wired.com/story/terror-industrial-complex-isis-m...

https://www.amnesty.org.uk/how-isis-islamic-state-isil-got-i...
Why migraine pain is not just a bad headache
Dirty money can afford good programmers.
But the same programmers are the reason for the heavy tracking in the internet and the FOMO dark patterns.
The two office jobs I worked in Austria both had me punch in and out.
Leaps of Faith
Of course not. Now there's a third way - Blueprints.

I've bitched about HA before and won't rehash all of it. The project requires a lot of time investment and the devs care mainly about playing with the latest tooling. From introducing and sunsetting a major installation method in the span of ~4 years to dropping Python 3.7 despite it not being EOL until 2023, I don't have time or patience to relearn everything with every little release.

Switched to Hubitat earlier this year. The GUI is ugly and there's a small learning curve. However it just works.
how has facebook's engineering tools directly and vastly improved the lives of ordinary people?

I really cannot find any examples anywhere of this.
It's a a long term trend - because the natural rate of interest is zero.

Money is a unit of account and therefore costless to produce, which means it has no intrinsic value. The value comes when you attach it to something. So in a competitive market the cost of a mortgage is the amortised cost of evaluating the quality of the borrower and their income stream, and is the price of preparing the mortgage, which is a financial derivative asset of a house giving the right to stop the owner selling it without permission.

Every interest rate cycle ends with the interest rate peak lower than the previous one, because it rapidly sends the economy into recession when you try to raise interest rates. This is because the belief about how interest rates work doesn't match the reality of how interest rates work.

People aren't spending all they earn, which means all asset classes rise in price relative to the indifference level of holding money vs paying off loans and paying taxes.

Japan is the canary in the mine and everybody seems to want to believe Japan is somehow 'special'. It isn't.

It's a natural result of the reality of banking. Loans create deposits. The cheaper the loan, the more loans are created, the more people downstream from the borrower earn and the more they can save. But those people that earn and save aren't the ones with the loans. And since those who are saving are not spending, the ones with the loans can't earn more to pay off their loans.

The result is a long slow credit expansion that interest rate changes cannot halt. And up goes the indifference price of incoming paying assets.
I am finding this specific comment fascinating, as your two sibling comments--which I presume, like me, are native English speakers (I specifically am from the mid-wear, importantly near Chicago, with a slight bit of Southern, and now I have spent half my life in California)--believe "not C" to be pronounced the same as "nazi". FWIW, they aren't the same, even when said quickly; but I will claim the difference is entirely in the syllable stress: nah-TZSEE (the T in "not" is unvoiced due to collision with the tongue position of speaking the letter "C", even when said slowly, unless "enunciating") vs NAH-tzsee; but the underlying sounds are exactly the same... similar to how "content" has to very different meanings as each of an adjective ("i am content with that") and a noun ("i posted some content") and are pronounced very differently, and yet the same ;P.
> ...as demonstrated in the new article

These new strains aren't even close to vaccine resistant, yet. Vaccines haven't been around long enough for that.
I bought a Hubitat earlier this year. It just works.

GUI's a bit dated, and you kind of have to get used to the philosophy. However, once you get the hang of it, it's reliable, easy, and flexible enough for my needs.
They’ve bought a house, moving out of state, moving in with their boyfriend, lost their job and moving in with their parents, been convicted and going to jail, etc, etc.
IIRC (don't work at Google myself, but friends do) - you start out of college as an L3 and are expected to make promo twice to L4 and then L5.

Once at L5 it's okay to just stay there and do good work, the pay is still really good and you're not expected to go beyond that unless you want to (and you're capable of it).

The main issue I've heard is that to go from L3 -> L5 there are incentives around 'impact' and launching products (or leaving for another company/startup and getting hired back).

This means people are incentivized to ship something to get promo, but working on an already shipped thing is bad for career progress.

An oversimplification, but seen through this lens Google's many chat apps make sense.
Well that doesn't sound very Google-y.
I know how to access these systems yet I steer clear of anything on them. The distributed technologies will never be as fast or reliable as the centralized ones. I'll not go into the quality or nature of the content and ecosystems around them.
> summarily judge them as "my inferior"

most organizations that tend to have office politics and are very politically-correct in their behaviour tends to end up with people in roles calling shots, despite those shots not being great.

graphics designers is just one example of this that i've seen, where a poor UI or bad UX is mocked up, but because you're an engineer, you do not get to have much input or your input is regarded as irrelevant (because your role is to code, not do UX design).

That's what i mean by the "inferior" comment - that the UX/UI designer isn't as good at their craft as you are in implementing code.
At least it’s open source: https://github.com/facebook/buck/blob/master/LICENSE

I do agree. Facebook doesn’t get a pass regardless.
china knows
The point is, people should be able to talk about it. Governments shouldn't decide for people what they can or can't talk about. Your opinion about the matter is one out of potential billions. They all equally deserve the same treatment by Twitter and the Indian government has no place dictating what kind of speech be posted on social media platforms.
Air still has the advantage- runway is not a function of distance to the destination, and runways are not destination specific.

So it's more appropriate to compare it to part of the station cost, along the lines of another boarding area & track, increasing arrivals and departures.
If they create additional demand they can make more profit for years. They are one of the few companies who are approved for anyone under 18. They could expand production based on this.
Won’t somebody think of the landlords? With this product they might make slightly less raw profit off the backs of people who work for a living!
ReactJS, PyTorch.
Zero carbon is a nonsensical goal. The carbon cycle is necessary. The issue is whether or not it ends up in an equilibrium pleasant for human life or not.
> forcing that traffic to be observable and modifiable in your own network means it will also be observable and modifiable by your ISP

This is factually false. And represents a key part of the problem in the rollout browser vendors have designed: Browsers should not be implementing their own network stacks. It's the wrong place to begin encrypting network requests, but for the "if you're a hammer" crowd, everything looks like a nail.

If the browser respected the OS stack, the OS could decide to encrypt requests, but it isn't given the choice. If the browser respected the network it's in, the network could decide to encrypt requests at the border, but it isn't given the choice.

Browser vendors decided the right choice was to build a product purpose-built to bypass nearly every good method of restricting malware, phishing, and, oh of course, ads. Google and their ilk would happily install ransomware on every PC on the planet if it would guarantee Google Ads couldn't be blocked, and that ISPs couldn't compete with their well-established surveillance tools.

The latter is why any suggestion DoH is to protect user privacy is silly... the user's privacy was compromised by the browser application pre-encryption. They just need you to believe the ISPs are somehow a bad actor for tracking you, so that only they can track you.
Why not direct these investments to Bazel instead?
The Us is already producing a new strain.. B1526 is iota
Other work from the same author (has been a public site for a while): https://bonkersworld.net/
> We're very very far from the point where it's more economical to invest in carbon removal than to lower emissions.

depends on what you mean by lower emissions.

Transitioning to more renewable sources is certainly a good way to invest resources, but it's not mutually exclusive to also consider carbon capture.

What is _not_ possible is for people to reduce their consumption. I, and many others, will not be willingly sacrificing the high quality of life that is the result of using a lot of energy. If people expect that climate change is to be solved by having everyone reduce their consumption, then that train of thought is doomed to fail.
Hawaii is not much of a defense as it has logistical reasons for its high cost, and anyway has a smaller total population than most major metro areas.

I'm not necessarily in the camp that thinks California isn't worth the cost. Though some undesirable location in the desert may indeed not be worth the taxes.
Postgres turns 25 years old today (?)
Twitter did take down tweets and suspended accounts.

They were reinstated.
Curious to know why alternatives are still being suppressed as a possible treatment. We need to start talking about covid management. We wouldn’t use it for those with lesser symptoms but for those who are hospitalized who may or may not benefit, it’s worth a try. I can’t see a constant booster shot being the only solution to this.
Sadly the most interesting CSS percentage mechanic is missing there:

background-position

Unlike all other cases, here `background-position-x: [25]%` means:

> "Place image so its inner left [quarter] boundary matches inner left [quarter] boundary of its container."

So 0% = align left edges, 100% = align right edges, 50% = align centers (= center) etc.
Super intuitive on the first sight, but I was quite surprised how thought-out it was underneath.

https://developer.mozilla.org/en-US/docs/Web/CSS/background-...
21 hours is equivalent to 3 hours though, things just get wonky when you cross the IDT.
so, like creating AWS Lambda?
I believe Play Store fees are 30% across the board. https://support.google.com/paymentscenter/answer/7159343?hl=...
Western Union doesn't have business accounts in most of countries. Normal transaction doesn't allow Business -> Business payments. They cannot send money to Iran (where we also have partners).

But you are right. Their fees are way cheaper than bank & Payoneer.

Ad on-ramp&off-ramp - sure. This is a temporary situation in which it adds some expense. Hopefully, people will have a chance to have cards refilled directly with cryptocurrencies worldwide (they already exist for major countries).
You can simply choose to not work at that scale if they're all making the world worse.

Part of an aspect of sticking to your guns ethically and morally is making choices that leave you worse off. If your ethics align with what is best for you, personally, it's not much of an ethical code
The slider knobs aren't vertically centered for me on that site (iOS Safari).
One small past thread:

Reminiscences of the VLSI Revolution (2012) [pdf] - https://news.ycombinator.com/item?id=18140297 - Oct 2018 (6 comments)
Sure it buys some value for the landlord, but that value is very low and can be replaced by software for 1/100 of the current cost.
No soap, radio!
>My laptop came with a driver that intercepts my keystrokes and sends signals to the keyboard so that it can light up the LEDs under the keys I pressed. What caused an insane design like this to even come into existence is beyond me, no doubt it came down to saving a few cents in manufacturing. I replaced this functionality with free software and I'm not sure if I even want to know whether there are any vulnerabilities in that driver.

That sounds pretty cool and hackable actually.
In the past I would agree, but anymore all of the recommendations are things I watched a couple of years ago. I'm not getting turned on to new, relevant content but refed stuff I 'liked'.
Yes- and imho, that's the way to do it. Make it competitive in terms of time and trouble and cost and usability. But it's still not going to be more energy efficient than air for most situations & destinations.
It was, yes.
The Maintenance Burden of Microservices
Autonomous teams is a popular idea in the industry today that tends to be associated with microservices. Autonomous teams fully own their services and are trusted to make their own decisions. The idea is that this will make them more motivated and productive. I fully support this idea. There are many other factors that drive microservices adoption such as scalability, performance, fault tolerance and the architecture of cloud infrastructure (i.e. the emergence of serverless functions etc.). However, multiple challenges arise when a team goes from owning a handful of services to owning dozens. Unfortunately I believe that when a team splits up its services on a micro scale it is setting itself up for a heavy maintenance burden.
24 dimensional stacking, and receiving and decoding signals from the Voyagers
Isn't that codebase in Java?
> I wish ground source heat pumps were more affordable

I don't think this will ever be the case. Water-to-water (ground source) and air-to-water (air source) heat pumps are effectively the same thing technically sans some tuning for temperatures, therefore the difference in cost of the heat pump itself is never going to be high.

The cost difference is in installation costs. Air-to-water heat pump installation is as simple as mounting the external unit and routing a few pipes back to interior unit while water-to-water installation is routing the distributed heat exchanger, which is significantly more labor intensive even if you do not account for landscaping (e.g. done as part of greenfield development which will have landscaping done anyway).
Sounds like a conspiratorial book that blames the very companies that have created drugs that keep cancer patients alive.
I think Google has a culture problem (they're massive, doesn't apply everywhere, etc. etc.).

There's a weird sense of internal entitlement where some (likely a small, but still substantial) number of people work there, are well paid, and yet act internally as if it's some terrible place doing terrible things (yet stay working there). Whatever way they rationalize this to themselves - it's odd. I don't have first hand exposure, have only heard things through friends that were employees.

Some of the most coddled/well compensated employees in human history acting as if they're in some sort of oppressive sweat shop.

Reminds me of this: https://paygo.ghost.io/why-did-i-leave-google-or-why-did-i-s...

The employees also pushed to avoid working for the USG, pushed to avoid the JEDI contract (though they likely would have lost it anyway) while at the same time trying to work within China (while Deep Mind may or may not be indirectly assisting in Uighur camps [0]). I think this is morally wrong and the arguments are often simple/naive.

[0]: ">>Peter Thiel: ...But somehow it’s very difficult to talk about this stuff coherently. I had a set of conversations with some of the Google people in the deep mind AI technology, “is your AI being used to run the concentration camps in Xinjiang?” and “Well, We don’t know and don’t ask any questions.” You have this almost magical thinking that by pretending that everything is fine, that’s how you engage and have a conversation. And you make the world better. And it’s some combination of wishful thinking. It’s useful idiots, you know, it’s CCP fifth columnist collaborators. So it’s some super position of all these things. But I think if you think of it ideologically or in terms of human rights or something like that, I’m tempted to say it’s just profoundly racist. It’s like saying that because they look different, they’re not white people, they don’t have the same rights. It’s something super wrong. But I don’t quite know how you unlock that."

https://nixonseminar.com/2021/04/the-nixon-seminar-april-6-2...
> life-cycle global warming emission of approximately 0.2 pounds of carbon dioxide equivalent per kilowatt-hour

"pounds per kilowatt-hour" has to be a strong contender for most ridiculous choice of units. One might almost use that as a joke.

Even "pounds per mechanical horsepower hours" would have been more sane.
For sure. Cryptocurrency community has so many fanatics it's not healthy either.

The thing is, some clown shouting diamond hands, HODL, to the moon, won't make it to #10 on HN I guess.
You say fungible, I say aggregate.

Here's essentially the problem you're laying out.

If I have a house run by solar power and walk to the store to buy fruit from 10,000 miles away to feed to my 5 children, my carbon costs are so astronomically high from the last two that the first two don't matter.

I agree! Absolutely!

But also, if transporting fruit 10,000 miles could be done with renewables that will zero that out.

If by the time the children are adults, significant delimited activity has transformed through say, better agricultural practices, more efficient appliances, better building design to that can regulate temperature better, all these small things, then the aggregate decreases

Stop having 5 kids and buying 10,000 mile away fruit, I'm with you. Sure.

But the point of this exercise is to make such things not so high cost so that the freedom to do these things, however much I personally disapprove of it, can be preserved.

That's one of the things the anti-climate change people don't get. They see the current transformations as a restriction of their liberties. No, it's a massive effort to preserve them. If we fail to transform society and cities start sinking into the sea, I assure you, forced sterilization, meat consumption bans, bans on private car ownership, local only food by law, a ban on air travel, it'll all be on the table. We all saw how quickly the shoe dropped on covid last march; from busy streets to boarded up ghost towns in about 2 weeks. We didn't heed the warnings to prepare and here we are still living with the consequences.

Let's stay on top of this one.
Atlantis is just like the GP's mentioned: a CI to run terraform plan then a person needs to examine the dryrun output. But it's still not ideal because Atlantis also has persmissions on production, and a (human) mistake could brought down your infrastucture.
I get your point, but I’m not so sure it’s a losing argument.

Brilliant minds could alternatively be doing equally brilliant things for any other company or organization than Facebook or Google, but instead, they do.

Shall we also marvel at the brilliant work and engineering that went into the development of the atomic bomb?

Perhaps nuclear advances still would have been made if the Manhattan Project had devoted its resources to similar research, but not with the goal of building a weapon.

Perhaps not. But I refuse to celebrate Facebook for what it is, and hope that we don’t need to count on it for engineering advancements.
The fact that tacking on the phrase “unreal engine” to an image generation prompt makes the image way better is both hilarious and kind of terrifying to me.

In the first generation of AI there was this idea that we could use AI to understand human consciousness; just make a conscious machine and then analyze it, pause it, rewind it, etc. The more we learn about AI, the more I think we’ll lose any chance to understand them long before they pass a complexity threshold where we start debating if they are conscious.

Communing with AI is starting to look more like some kind of Eldritch incantation…
AoE Salon #44: We say “Satyagraha”, they say “sedition”
I don't think Google uses user photos to train their photo search algorithm.

They use photos from the web for training, and then user photos are only used for the actual indexing.
The standard unit is gCO2e/kWh (grams of CO2 equivalent per kilowatt hour).