skysight-inc/HackerNews huggingface dataset:
Yes. But we only get one influenza vaccine per year. The expectation has been for antibody neutralization coverage (not just T-cell mediated infected cell killing) lasting that long.

15 weeks is rather short. Additionally, it's not really 15 weeks. The study time scale starts at the 1st vaccine dose (week 1). Then it's 3 weeks until the 2nd dose and 2 more weeks till full protection. So the actual protective coverage span in this study is week 8 to week 15, or 7 weeks.

This study being held up as proof of long lasting immunity doesn't hold water. It is not bad news though. Decent B-cell responses (though tailing off) till 7 weeks after full vaccination is good. But we definitely need to know what happens after the first 2 months too. This exact study should be repeated again in 6 months (24 weeks).
Oh, no, is this a Musk-worshipping ecosystem? RIP my karma points
No discussion of Workflowy (https://workflowy.com/)? It is, in my opinion, by far the best note-taking app I have used. You can search, reorganize, and freely move content as you take it, and also after. You can nest a whole campaign of D&D notes next to your favorite recipes, and it feels natural due to their focus level model. More importantly, it's absolutely dead simple, and it "gets out of the way."

The author dances around the two main properties that all good note-taking methods have:

1. It's easy to add new notes
2. It's easy to look through old notes to find what you want

Pencil and paper, or bound journals, do the former very easily. The latter is much harder, unless you start some indexing system (such as a bullet journal solution). This suggests searching and tagging are ideal, which digital is good for. But, and I cannot stress this enough, (1) is more important than (2). It is not impossible to find information in hand-written notes, just harder. But the exact moment it becomes hard to take new notes, the solution fails because you won't use it. And I believe Workflowy does all of this, with quick nesting, easy extension, and even quick reorganization. And you can quickly drop into "just let me write some notes," then go back and organize later (even splitting your notes up into subcomponents, if you want).
I don't care about this business. I'm responding to the rant of poster above me.
51 years and criminal care.

But if we are comparing concrete and wood as construction material we should use buildings that can be built with either.
> It’s not perfect - Markdown, or at least code blocks, would be nice, and tags (I think those are coming in the next OS release), but in terms of ease-of-use, I haven’t found anything close.

On that note (no put intended), I’d expect iOS 16 Notes to support markdown now that SwiftUI and UIKit in iOS 15 now have native markdown support.
In abstract, no. In practice, in this case, yes. This was an odd way of channeling money into private pockets of well-connected people at MIT.

Anyone know of a good way to reach a good investigative reporter?
I've got it on order. But I may ultimately decide to stick with wired Internet anyway. What I really want is for Starlink to open up for mobile use. When that happens, I may reverse my camping style and instead of going out on the weekends and coming home during the week, I may come visit home on the weekends and stay in the wilderness to work remotely :)
Australian scientists break down in tears over climate crisis
natfriedman is a human being like you and me, not an AI; let's treat them with consideration for that.
Thanks. I didn't realize that. I assumed with the size of gaming laptops they would all have webcams.
This is a great use of the OpenAI Codex. It's fast in VS Code. My early impression is that the more popular the language the better it does. So Javascript is almost magic and something like Rust still useful. I'm looking forward to using it more.
I fixed my editor so that it recognizes URLs, and underlines them. Clicking on one brings up a browser on that site. I should have done that 20 years ago.

No special syntax is required. It just works. I've since been adding URLs in comments all over my code, for references. It's marvelous.

It could be extended to recognize filename.jpg and filename.mp3 to display or play those files, too. Again with no special syntax whatsoever. It just works.

https://github.com/DigitalMars/med
> I invite you to try automating this and let us know what happens. Try creating, let’s say 1000 accounts and try liking or posting and see what happens. I’ve seen that system at work and doubt you’d get very far.

Yes, naive attempts at manipulation will be detected these days on big platforms. 5+ years ago such naive attempts were successful, though. A few years ago I made a proof of concept to show how easy it is to make new Reddit accounts and automate them, and had registered hundreds of accounts. Those logins still work even though Reddit has cracked down on naive automation attempts.

Today, that's why many firms buy real users' accounts. They'll hire people to manually login to the accounts and post. There's also the perpetual cat and mouse game between bot creators and platform owners, and the platform owners who benefit from the appearance of increased growth and engagement that's actually just bot activity.
I saw the darpa moderna post but do you have other keywords to search for the explanation post?
I'm having a hard time understanding your question because the only way I can interpret it seems to imply that you think it is better to lie to people about the status of a medical treatment than it is to be honest, in a gambit to ensure more people accept administration of the treatment.

Is that what you're implying?

To directly answer your question: I do not think the ethical calculations change one single iota based on any other outside calculation.

You should never misrepresent or elide any relevant information from people when they're about to make a decision about their health (or, hey, ever, in any situation).

It seems you're thinking if we were honest with people about the status of the vaccines, they'd be less likely to take them.

Like, here's the messaging I think is appropriate: Hey, we have some limited safety and efficacy data about these vaccines. The limited, phase 2 information shows that we think they're safe and effective, however, these vaccines have nowhere near the testing and trials that normal vaccines have prior to authorization. As well as lacking phase 3 long-term study, we eliminated animal studies and animal toxicity studies for some inexplicable reasons, so we're flying a bit blind. But we're in the midst of a deadly pandemic. The risk is yours to take.

I think the majority of people would still take the vaccines.

I think you think we should lie to the masses because they're too stupid to handle the truth.

I think that's evil.

The point of principles is to practice them when it's hard, not when it's easy. If you abandon them when it's convenient or during an emergency, you don't really have any principles.
> Deprecating a whole generation of hardware that do not meet minimum requirements will generate sales for Intel, AMD, and PC OEMs.

Is Windows 11 even compelling enough for people to break their normal hardware upgrade schedule?

I have more Windows machines than I'd like to admit, and only one of them (purchased this year) can run Windows 11. I'm in no rush to upgrade any of the other, non-qualifying devices any time soon, as they are more than usable in their current state.
At least there's still Khan Academy. Very different niche, though – I sure wish they'd been the new homes of edX's content…
Is this a joke I'm not getting? Do you think he hopped off his skateboard at 19 and became a VC?
It's not really a Firefox thing. It works on everything on Linux as far as I know, emacs, terminals, libreoffice writer, etc.
All those new machines will have to buy a Windows 11 license.
I mention SALOME above - it's a bit of a sister project to FreeCAD, and it has extensive mesh generation facilities as part of its role as a CFD pre-processor. I've no doubt you could use this to assert fine control over a surface mesh export.
> i disagree fundamentally about the question.

Maybe you're in the wrong thread, then?

> for me, the question is: how can we prevent the virus from mutating enough to escape vaccine

Probably not with a vaccine that is not quite strong enough to prevent spread, but simultaneously strong enough to put selection pressure on the virus.

> the answer is to stop the virus from infecting a host in which it can mutate freely and from which it can escape. we don't know these people, so we should aim to vaccinate as many as possible before it finds another person who walks around with the virus for multiple months with no symptoms, accelerating natural selection thousandfold.

The scenario you are describing is the immunocompromised person whose body can't quite kill the virus, but also puts selection pressure on it. Such cases have been described, but whatever mutation would come out of that is not necessarily going to be much more effective at overcoming the defenses of a normal immune system.

The Sars-CoV2 virus will almost certainly stick around and it will keep mutating, even with the best of vaccination efforts. Nature finds a way. We'll have to get used to it.
> Again, from what we know today, it is safer to vaccinate your kids then driving them around in a car.

...and if it were choice between vaccinating kids and driving them places, then this example would be relevant.

We don't approve drugs simply because they're less risky for a target population than some other selection of risky things.

> Even when the risk/benefit profile is even/negative, absolute risk is super low.

Yes. So is the benefit.
> I’d take NHS (despite its flaws) over my >2k /month health insurance any day of the week.

Would you also take the 40% reduction in post-tax, post-healthcare, post-retirement pay?

I actually favor a stronger social safety net and I agree that we need to reign in inequality (because an egalitarian society of very wealthy people and very poor people strikes me as completely infeasible in the same way that a prosperous socialist or communist country is completely infeasible), but that will almost certainly mean the professional class is worse-off. Reasoning soberly about tradeoffs is imperative IMO.
He is talking about doing great work, not about becoming rich or successful. You do need luck for your great work to take you places, but your own agency counts for much of your ability to do great work. Plenty of great work will not reap great rewards; it is done because someone feels that it has to be done.
It seems like a lot, when each Satellite seems to only support 20Gbps or 40Gbps.

So to support 100Mbit customers, you need to launch a Satellite once for every 40 customers. Each customer needs a $1000 to $3000 dish to connect to the Satellite (currently $500, so you need almost a year of $99 subscription before you make back the money from the dish alone, and then another few years to recoup the costs of the Satellite launches).

This at a time when 5G is beginning to be deployed in mass quantities... and Gbps fiber is available in cities. So cityfolk won't really use Starlink, and 5G will cover many rural areas.

Finally: ~~directional WiFi~~ (Woops: got my terms mixedup. Apparently its "Fixed Wireless") works surprisingly well out in rural areas for 50-mile ranges. So if you can get a line-of-sight radio out there, a small town ISP can still deploy over a relatively rural area.

EDIT: Directional Wifi is like 1 mile. I got my technologies confused.

Only the most rural of areas (over 50-miles away from the nearest potential directional WiFi spots, with no access to 5G or Fiber Optics) would use Starlink, which is... not where people live by definition. Can Musk find millions of rural folk and build an internet service with them?
Hmm. Yes, you are right.

For what it's worth, the ratio of English language seems to be higher for the programming MOOCs than it is for most the other subject areas.
Brilliant fan fic!
The downvoting is because it's a low effort comment that is more about being snarky than attempting to provide an insightful comment.

Elon Musk has legitimate reasons for criticism; sarcastically dismissing him as a charlatan isn't a productive way of doing so.
The Standards Wars and the Sausage Factory (2014)
I won't fault you for the not unreasonable assumption but not the case for me. I have fond memories of sleeping behind a friends couch while securing a job at the ski resort. Initially working at the resort from 4 to midnight so I could ride every day. Sleeping in dorm style housing slightly worse than freshman year of college. Working my way up to running the ticket office. Somehow not blowing all my money on new gear, saving just enough to buy a $59k condo at the base of the resort which I still have. No financial safety net, no savings, but also no dependents and nothing to lose living in one of the greatest areas of the country.
Optery is U.S. only at this time
Option #4, Theo was responding to virtualization advocates who claimed VMs offered as good or better security isolation than physically separate boxen.

At the time and in some cases still today, plenty of advocates still make that claim. Many others just assume the truth of it, if only because to question it would cause cognitive dissonance with the prevalence of cloud hosting. (Notwithstanding that some savvier companies use EC2 much like they would a traditional server leasing provider, using instance types that take up the entire machine. Security and convenience is sometimes a trade-off, but some bargains are better than others if you don't succumb to simplistic, categorical claims. Which is what Theo was railing against.)

EDIT: For context, here's the original post https://marc.info/?l=openbsd-misc&m=119318909016582. It's from 2007, when hardware virtualization extensions were new and all VMMs had to emulate network interface cards and similar hardware. These days virtio devices are common place, which helps to substantially reduce footprint. OpenBSD even has its own native VMM, which of course only supports virtio devices.
> investment costs before Starlink achieves fully positive cash flow would be $5-$10 billion.

This does not seem too bad, considering that majority of that cash will be raised once most technical risks are addressed.
TPM 2.0 seems straightforward. Windows is their client for integrating with services they actually monetize - Sentinel, Azure, 0365. In order for those services to compete they need a client that has these capabilities. TPM 2.0 provides that.

The intel generation could be moved back one, I believe, and still meet their requirements though.
You do it roughly based on the deployment requests and the average HPA values throughout a time slice.

Most k8s workloads run on a homogenous set of node types, so you can have an hourly cost per gb and per vcpu without digging too much into it.
The article isn't wrong or incorrect in itself, but since the definition of "doing great things" once again centers on extreme Bill-Gates-level success, I take issue with two points:

In these extreme examples (Gates, Bezos, Musk, etc) the environment is the true differentiator to go from success to extreme success. Not talent, not working hard. Doing the right thing at the right time in the right environment creates the snowball effect. It still requires hard work, but hard work is not rare or unique. Bezos is about a 100.000 times richer than a "plain" successful millionaire, so surely hard work is not the game changer here.

Success requires hard work, extreme success requires luck or foresight. In the case of Gates clearly luck, as he pretty much missed every single tech trend in the decades to come. He has zero foresight, but I'm sure he worked hard in his most energetic years, like pretty much everybody.

I protest against leaving out the luck factor as these people and their admirers truly believe they are some god-like character, a 1000 times smarter than everybody else.

There has been an entire industry trying to replicate the success of Jobs, for example. As if you can replicate that. You can't replicate any of these outcomes as they are time-bound. You can do exactly what Jobs did and the outcome would be shit, no matter your talent or how hard you work.

The second part of my protest is completely leaving out the enablers of your success: workers. 99.9999% of your wealth in the case of extreme success is delivered by them, not you. Not even mentioning that is classic hero admiration. And this doesn't even go into how often the relation is highly exploitative. We know the issue with Amazon workers, as well as the true reason of Microsoft's success: the merciless elimination of competitors in criminal ways.
Shorter people have a lower center of gravity which is an advantage for players maneuvering the ball through the midfield. There is certainly a trade off with strength and vision but Messi's body type is hardly unusual in top flight football. Xavi and Iniesta, who played with Messi on Barcelona, were superstars and all three are 5'7".
> Meshroom definitely can't do 3D reconstruction from monocular video.

It's quite possible we're not talking about the same thing here, but for my understanding of what "3D reconstruction from monocular video" means, Meshroom most certainly can do that.

To wit, I recently shot a video of a house with my drone, which happens to have just one camera. I then proceeded to extract the frames of the video and fed them to Meshroom.

I am now in possession of a full 3D textured model of said house.

[EDIT]: now that I've watched the video you posted, I see they do the reconstruction in real time, which is cool and which Meshroom can't do. However, if you aren't in a rush, the end result is the same.
I'd be surprised if a company's legal department would be OK with that 0.1% risk.
Mining as in those big trucks or mining as in trains on tracks?
Did you find anything about the current post, "How to Work Hard", contentious?

Honestly that'd probably be the one criticism I don't have.. most of the content I've seen is pretty mild-mannered and mundane.
Yes and the other problem is using Gates as an example is the problem of extrapolation from an outlier.

Taking a survey of 100 YC participants would be more interesting.
You seem to be under the impression that the large blocks of voters actually understand and care about the issues. Large corporations and their considerable advertising and lobbying efforts are what's really important. Much of this effort is to frame issues to the public in the way they choose.

The "stances" the voting base take are largely shaped by influence campaigns of powerful interest groups. Both major parties (the minor ones too) are affected by this. Though one of the groups has gotten even stupider recently, and they actively vote against their own best interests.

Edit: grammar.
Except that only works when the distance field accurately represents Euclidian distance, which it certainly won't the minute you apply any sort of non-trivial distortion.
"Software eats world" just got more real. Funny that programmers thought they were eating the world with software, now, software has eaten them.
> Microsoft claims that a combination of Windows Hello, Device Encryption, virtualization-based security, hypervisor-protected code integrity (HVCI), and Secure Boot “has been shown to reduce malware by 60 percent.”

You know what else reduces malware even further? Installing Linux.
For me, the dread is in the preparation. Once I'm on the proverbial stage, everything is usually good if I have prepared a good presentation. There is definitely some pre-stage anxiety, but I know it will go away when I actually present.

But the preparation, I hate it so much. Sitting in front of that empty window and trying to come up with something that makes sense, then refactoring it multiple times. Practicing, identifying stumbling points, fixing them... I put it off as long as I can, but not how I put off some programming work if it's boring, instead I put it off because of how dreadful it feels. This is somewhat of a vicious cycle, because there's only so much on-stage adrenaline and maybe resulting improvisation power can do: To have a good talk, you have to have a good preparation, but if you put it off because it is so anxiety-inducing, the fear that you are not prepared enough as a result is even more anxiety-inducing.
i think the quantity of scams generally increases in bubbles
Author of Open edX left a long time ago due to corruption at edX / MIT. See commit log for who built the platform. See press releases for who got the credit. MIT promised all open courses, all open platform, all open everything.

The $800M will be used to line the pockets of privileged MIT professors. It will be as effective at closing equity gaps as supply-side (trickle-down) economics. 60% will go to overhead, which will fund faculty clubs and yachts. From there, a ton will go into generous salaries and benefits packages. And so on down the line.

I am willing to bet that this will be equivalent to giving maybe $10M to an HBCU, in terms of benefits to the poor.
But there's also the subtext that if you find yourself at the lower-skill portion of your particular industry, then you should probably have a contingency plan to avoid being automated out of a job, such as retiring, learning more, or switching to an adjacent field.
Tesla is 80% of the US BEV market. Which manufacturers make their electric vehicles easy to work on?
- building and maintaing roads is a government handout. It artificially lowers prices.

- building and maintaing roads expands the role of government. It's an extra program for the municipality to manage.

- Expanding government programs is a tax on residents, even if they don't benefit from building and maintaing roads.

- building and maintaing roads is hostile to business. Companies cannot reasonably compete with a service that the government pumps money into.
This makes sense if you know nothing about how Microsoft is structured or making money, but otherwise falls apart. Windows licenses are not what they're prioritizing.

But it is obviously money - kinda silly to point out that that's why a business does things, but yeah, you nailed it.

Microsoft sees threats to its business in a number of forms, and believes that this hardware requirement will address them.
So basically youtube all over again? I.e bootstrap and become popular by using widely available whatever media (pirated by crowdsourced piracy) and then many years later, when it gets popular, dominant, it has to turn around and "do things right" and guard copyrights.
Svelte does two things very well: it's easy to integrate with other vanilla and not js technologies and opens up the space of your solutions. You don't have to have full buy in in it. You are not forced to do things how the framework want you to think about them. That's alone is a big win against React in my book, where you are not doing web dev, you are doing React dev, and sometimes that is way too constrained. That's is also a reason why Svelte is not irrelevant. It doesn't need to become React to be useful.
far from it, this thing won't write full applications by itself
Ditto! Man that was a great spot to live so much to walk to nearby and you have a caltrain stop right there.

I remember walking through that tiny park reading the usual signs when I read the Palo Alto one. Its very unassuming and I was so surprised I had to look it up and verify I had it right.