skysight-inc/HackerNews huggingface dataset:
If you make a connection between genes and disease, it is often a complex/weak link. Most of the on/off genes have already been discovered, by now we have gotten down to the more complex ones based on interactions, etc.

Having worked with genetic data a lot I know that the reason for the wealth of European genetic data therefore lies in the limited generalizability based on more diverse datasets.

If you try to generalize from a worldwide genetic dataset, you will probably fail. Your inferences from this diverse dataset to individual genomes will be abysmal. Predictions are already difficult to make from a country-specific dataset to an inhabitant of such country.

I don't know why people always want to see race everywhere. For scientific reasons, it has been way more convenient to sequence more people of European origin. In my opinion, that has nothing to do with racism. It is a matter of what data has better availability and is more valuable right now (not even in terms of application - simply in terms of being able to detect complex underlying patterns).
Now that the cost of sequencing is getting lower and lower and availability increases everywhere, it is great to see more diverse genomes sequenced. This will help us understand more of the genome - still, this is no magic bullet by a long shot. The problems stated above get bigger with dissimilarity. Many discoveries made in African genomes can probably not be generalized unto the remaining world.

Current methods are just not sufficient to dig deep into the genome and its mechanics. At this point, we would probably need to sequence the whole of earths population a few times to be able to make consistently accurate and significant predictions across many complex traits and diseases.
Different strokes for different folks. Seen this at a few cafes on the East Coast, but it's not the norm as dine-in is barely returning.
Anyone have any experience using a Java treeshaker? I have a Clojure GUI/JFX App that's bloated and I've only managed to slim it down with manual package pruning.

I couldn't get Proguard to work with Clojure. Granted proguard is quite baroque so I probably did something wrong. But maybe there is some simpler solution out there for the JVM? Or would this simply be impossible b/c Clojure uses reflection? Though so does Javascript from what I understand..
On the other hand, I have enough sensory overload as is, without tasting the EM field.
"The markets can remain irrational longer than you can remain solvent." — John Maynard Keynes
U.S. marijuana ban 'may no longer be necessary' – Justice Thomas
It was very little effort to setup. Used puppet to define everything I wanted the infra to be, and have pretty much left it be.

It's only reachable from the app servers, backed up to tarsnap.

It's really not a lot to learn and hasn't been a chore to operate.
So you are saying that because we need to do validation in a very specific case, we should just throw the towel and do validations every time?

The IO entry point of your code will always be unknown no matter what programming language you are using. In typescript, you do validations in these cases to make sure outside data fits into your type system, from then on (probably about 99% of the rest of the code) won't need any validation whatsoever because the compiler is already doing it for you.

Bloat is the amount of time you lose doing code review to check if things are possibly null or doing null checks on stuff that is never null or a bunch of other stuff that the compiler will do for you just by writing some minimal types.
The compiler does this stuff automatically without getting tired, can't say the same thing for humans.
Survey on displaying “skills” on GitHub user profiles
> After that you don’t get much from it and you should use something that uses mini stories with a larger context and preferably audio read by natives

Duolingo has mini-stories, at least for Spanish, and has had them for a while.

They're usually around something happening to a bunch of characters. In most of the recent stories, there is a larger group of characters who all know each other and have interconnected "adventures".

The lessons then become not just translating random, out of context sentences, but listening to the story and answering contextual questions. They do seem fairly basic, but I think the basic idea is already there, it should only be improved.
Censorship itself comes in many forms, as in the self-censorship you expressed.

Definitions of words are complex since they mean different things under different contexts.

As we’ve been using it, I believe, censorship involves some type of authority censoring those without power’s voice, whether that’s a citizen of an oppressive country, or a user of a website beholden to the authority if it’s owners.

In the broadest sense, then yes, any content that is suppressed falls under censorship, in which case nearly all content we consume is censored. Truly objectionable material such as horrible graphic violent and/or sexual material is censored across almost all venues.

In practice, this is usually not referred to as censorship, and I think it would take some sophistry to assume the parent is implying all suppression of any kind is “censorship”.

Instead the context I understand we are talking about is in line with religious, political censorship etc, where there is a motive to impose moral values, or hide facts from the public.

So while you could define censorship as any suppression whatsoever, context matters. And when the context involves the parent talking about “free speech rights being censored” then the historical aspect and that context is what should be considered.

In that context, calling moderation of internet comments “censorship of free speech” is both horribly uninformed of historical examples of true censorship of free speech, and also a false dichotomy (either we have 100% free speech or horrible censorship).
Or correctly added a recent performance (the performance/recording is copyrighted, the underlying composition is not) to the database.

I guess another way of getting around that would be to get multiple copyrighted performances of a public domain composition added to ContentID.
It would actually be quite amazing if dead code analysis of branches are integrated into eslint or other linters.

But yeah, I guess that would also require a VM like understanding of timeouts, intervals and the Browser's triggered events so it's kinda hard to do.
That depends on what exactly the experiment entails. But since you're the one suggesting feel free to email me with the details. (: My address is @exia.io; you can use any username since I have a catch-all for the whole domain.
Airdisc Air Conditioning Technology
It looks excellent. I guess it would make more sense to watch the original dub, the English dub seems a bit off to me.

And yes, not many people will watch Russian or even Chinese movies here in the West. People prefer to watch Hollywood - and the exotic tastes watch Japanese anime productions.
Most other compiled languages do dead code elimination, which sounds similar but is a little different. Think of dead code elimination as removing code that doesn't change the output, while tree shaking instead includes code that could run.

To apply this to python is interesting - if you were creating a packaged version, I could see "compiling" the code to a separate package with only the required imports.
Mission Impossible?! :-o

That’s James Bond of course :)
How many people who aren’t invested in it themselves are predicting it to be over 100k?

The whole system will continue to work until the money isn’t coming in. I know nothing about investing, but come on, this one is obvious.

The only question is when will the money stop coming in?
It looks like a perfect SaaS opportunity.

A good menu generator, with competent web layout, readable, zoomable, searchable. Results may be hosted or sent as a bunch of static files.

The menu SPA page collects patrons' choices and forms a nice order for the waiter, as a text and as a QR code.

Flat monthly rate for up to 200 menu updates a day, effectively unlimited but preventing abuse. A small flat fee for serving the menus online and generation of the QR code. One-time fee for each piece of personalization / branding work beyond the standard templates.

Looks like a perfect side project for a couple of weekends, and then incessant low-intensity marketing efforts.
If the author's think genetic mapping will cure racism they're very naive.

It's still a great project though.
You are making up the qualities of good currency, and then conclude BTC has none of them.

Qualities of good money are 1) Durability (not losing value with time), 2) Portability, 3) Scarcity (limited supply), 5) Divisibility, 6) Acceptability and 7) Storability.

BTC has all of them except maybe 6). And I'm no defender of BTC, I don't like it and I don't think it will ever be the main currency. It will be at best like the gold backing the day to day exchanges in another kind of "coin", and used only for clearing.

Money can be, and currently is, as "fungible" as annotations in a ledger. Banks are not that different from BTC, except they don't need "proof" because they limit who can add transactions: a VISA transaction is just "write in the ledger -X for this wallet and +X for this other wallet". No gold, bills or any fungible asset is moved around, exactly like BTC.
I recently learned a trick to fall asleep faster. The theory is that sometimes we have trouble falling asleep because we’re stuck in that “logical mind” mode, ie verbalizing thoughts in our head, thinking about concepts, etc.

The trick is to pick a word, something like “bed”, “sleepy”, etc. You then take each letter and try to think of as many things that start with that letter. The catch is that you should try visualizing the object as clearly as possible. You move on to the next letter once you run out of things for the current letter.

This is supposed to move your mind from the verbal, anxiety-ridden, future-minded mode to the pre-verbal, visual mode. That then slowly fades into hypnagogic imagery, which then leads to sleep and dreams.
> and then stream of images appeared from single point, that point grew and like accessing some optic cable hole, and it was vivid very vivid like reality. It lasted just a few 10 - 30 sec before I was knocked of and started sleeping.

That would be hypnogogic hallucations[1]. Different from aphantasia[2]. People with aphantasia can typically experience hypnagogia just fine.

[1] https://en.wikipedia.org/wiki/Hypnagogia

[2] https://en.wikipedia.org/wiki/Aphantasia
It's primary reason is image. That's why it's mostly Harley-Davidson, not Indian motorcycles, that roar past. Not that Indian can't be loud, but the former has a reputation that's exacerbated by owners riding at high RPM or modifying the exhaust system.

More to the point, do you believe an exhaust system quiet enough to be legal is still immediately noticeable over highway-speed road and wind noise, sound-deadening, climate-control fans running flat out, and any media playing at any volume?
But if you were, say, The Pirate Bay and all you are pinning is the torrent file then it seems like that might have worked as torrents are only a few kb in size rather than a Gb movie file? What was the name of the site?
Sure you could connect with people, but you wouldn’t connect with Firstname Lastname, you would connect with some nickname that you were associating with some cool stuff they had written about.

It was not inherently about people, it was about what those people managed to bring into virtual existence that was interesting, and it was that you wanted to connect with.
The slicker you build the road, the less noise and traction you have.

There’s a whole science around balancing noisiness of roads and brake length.

Porous roads sounds like sand or gravel. Not great for driving or for noise.
Not OP, but I wouldn't say significantly more dangerous, no. Older aircraft sometimes have to undergo modifications to mitigate faults that have been discovered over time in order to stay airworthy. By and large, a 50 year old aircraft is going to have well-understood failure modes with mandatory steps to mitigate them.

The mechanism by which this is enforced is an "Airworthiness Directive" if you want to read more about it.
Source: I used to fly a small 50+ year-old aircraft recreationally
So, I'm no lawyer down there, but this is how it was explained to me by a friend down there.

What they're doing is within their constitutional mandate. It takes 5 cases to set a precedent, at which point the legislature is on a timer to take action and codify it into law. The 5 cases on this topic happened. The prohibition was found unconstitutional. The legislature has been dragging their feet for 3 years now, repeatedly asking for extensions. As the legislature has failed to act within their given deadline, the court has the right to refuse a further extension, and to take action themselves.

This is not the court abusing it's power, this is the court protecting the constitutional rights of Mexican citizens, as they're exactly supposed to.

You're projecting your own politics, I assume US based, on a totally different system. Don't do that.
Tether will work until the day comes when there is a net outflow from Tether. Then it will all come apart, because the backing assets aren't all there.

Like Madoff's fund.
They are also no good if you don't bring your phone with you. I generally leave my phone at home unless I expect to have to make a call or something. If the restaurant doesn't have a paper copy somewhere, I'll just leave and go find another restaurant. There are tons of restaurants, and I'm happy to vote with my wallet on this one.
Crack and cocaine were treated differently by the laws because their social effects were seen as different. Crack was seen as destroying inner cities in the 80s and those disproportionate punishments were directed at the dealers in an attempt to protect those communities. The black caucus in congress pushed for those laws.
Is physical attack a common method to breach a datacenter? Sure you need some physical security and auditing but I would imagine the main threat is online.
The mimix whitepaper seems to be offline. (No longer in wp-content) would love to read more about your ideas!
I'm specifically referring to the phenomenon that certain artists get lifted to semi-god status where even the sketch of a football on a restaurant napkin suddenly becomes news-worthy.

"Hey, take a look at these sketches."

"Nice. Seems like the typical sketches of an arts student."

"But these are by Van Gogh."

"Oh. My. GOOOD!"

Well, obviously I'm exaggerating for dramatic purposes but my general point should become clear. The man was an outstanding artist, no question about it. But that does not mean that every single thing he did, every careless sketch he jotted down for who-knows-what purpose needs to be met with stunned adoration.

When it's not about the artistic merit of the sketches but purely the fact that they were drawn by Van Gogh, then the focus is not the art but the artist. That, in my opinion, qualifies as "fanboy-ism" although, of course, I chose this term also in parts for its controversial connotation.

Given his status in the history of art, there could be a second interesting aspect to such a discovery: do these sketches tell us anything about Van Gogh's life that might be relevant and hasn't previously been known? I don't see that here, either.
> self hosting your database (even in the cloud)

> my data is far too valuable to put in the hands of a third party

Confused, you self-host "in the cloud" without a third party involved? What does that mean? Are you not counting the party hosting your machine?
That goes against that specific implementation then, not against the concept, and not against how the feature should be implemented now.

I was critical at first as well. But I tested it on the site I linked and on other sites with bigger images, and it just worked that well that I stand to what I said. This feature is a net-positive and in most scenarios the loading will either not be noticeable, or it will be an advantage overall.
Related, here's a video by PBS Spacetime on how birds navigate using quantum mechanics: https://www.youtube.com/watch?v=0A1ouV7iD8o
Graph Neural Networks – Libraries, Tools, and Learning Resources
2013. 2017. 2021.

Three in three.
They ones that count, are not. Bitcoin has no plans to, and Ethereum is delaying PoS for political reasons.
> evolution had humans use their absolute income/wealth to judge their relative status

This is false thru history. A noble man could be higher status than a rich merchant, to not talk about race.

The article gets what could be some reasonable conclusion from wrong data. It seems that the author started from an opinion, and then build a case around it.

> low level workers are often well advised to “keep *their* head down”, and just do their job.

> *we* all tend to rise in status when we seem to influence the behavior of others, but fall when lower status others seem to influence us.

Also, from the article I have an strong feeling that the author thinks of himself as high-status.
> it is (at least with the people i know) considered ab-so-lu-tely rude to even get your phone out

Whereas with people I know, it's not because / people have kids|partners they check in with / people sometimes just don't have the energy for constant peopling and the phone is a brief respite / people are sysadmins|on-call and get occasional blip warnings / people are checking on something to answer a question / etc.
Unfortunately this is pretty accurate. Pharmacy Benefit Managers (PBMs) are contracted by insurers to set the formulary, in effect the list of drugs the insurer will pay for. They negotiate to lower drug costs, usually via manufacturer rebates.

Where this is perverted, is that the PBMs have complex compensation schedules wherein they receive a percentage of drug rebates. Their goal is to secure the largest rebate possible. Thus, either negotiate more effectively OR pressure manufacturers to increase list prices and give larger rebates. In practice, the latter happens most often. Insurers don't mind high list prices because they get large rebates and it encourages people to stay insured. Net prices (pharma revenue) on off-patent insulin have declined consistently since mid-2000s [0].

However, insulin is inexcusably expensive due to legacy regulation about equivalence for biologics and sticky patient preferences. Even current net prices are 2-5x too high relative to what a competitive generic market could produce.

[0] https://www.fiercepharma.com/pharma/net-prices-for-insulins-...
Makes sense.

> Question: is there a comparable service for postgresql like mongodb atlas?

There is no company behind Postgres. So, the big public cloud providers are providing their hosted solution.
Ask HN: Should I tell the HR that I recently joined a company
I recently got an offer from a company and I am joining them from next week, before that I was a freelance dev.

However, I have an upcoming HR interview with a German company this week. This opportunity is better than my current company. I am not sure whether to tell the HR about my new company or not, I don't want to be perceived as a job hopper.

Should I mention about my new job to HR or just tell them that I am still working as a freelance dev?
Whether more drugs will be used by more people depends in large part on how legalization is implemented.

If, say, heroin ads and a wide variety of colorful heroin preparations with outrageous claims are allowed when heroin is legalized, as they are with cannabis then yeah, it's likely that use could rise significantly.

But it's unlikely that the legal heroin market will be allowed to be the kind of free-for-all that cannabis has had. Ads will probably be forbidden, and there'll probably be just one or a handful of heroin preparations in white-labeled containers, as there are for generic prescription drugs... and you'll probably need a prescription to get it too... and you'll probably need to register as a heroin user and maybe even be required to undergo treatment.

So that's a totally different approach to legalization compared to cannabis. Heroin and cocaine, if they're ever legalized will be heavily regulated, and then not nearly as many people will be drawn to using them, compared to cannabis which most people think is harmless and which is advertised heavily wherever it's legal, with a million enticing preparations of all kinds and no prescription needed to get it.

Something else to consider is the example of the Netherlands, where it was shown that Dutch teens were much less likely to use cannabis (despite it being effectively legal in the Netherlands) than their American teen counterparts when cannabis was illegal in the US. The Dutch teens just didn't think cannabis was cool, unlike American kids who were drawn to the forbidden fruit.

So, paradoxically, drugs can be made to be less enticing when legalized than they are when they're illegal.

Yet another thing worth mentioning is that pretty much everyone who actually wants to use a given drug can freely do so now, while it's illegal. It's not unavailability but disinterest or fear of addiction that's keeping most non-users away right now. That won't change with legalization.
This looks amazing - well done! I’ve started dabbling in hardware about a year ago. Starting with the Arduino starter kit. But somehow my brain doesn’t seem wired for it. It feels like all the pieces are there in my head but I’m unable to draw the connections.

I built a self igniting torpedo heater for a powder coat oven but even though it worked, I still feel like I stumbled through every step instead of understanding any of it. Like building a piece of software using SO snippets and just trial and erroring it until it works ;-)

Do you have any tutorial (series) recommendations for semi beginners on stuff like this? Maybe some “hardware explained for a software developer”? :D
Legalization doesn't have to mean you can buy packets of heroin at a gas station.

It can mean you have to go to a government-run outlet, and if it's your first time, someone is going to ask you some pointed questions about why you want to buy it, make it very clear to you that heroin addiction is a real risk and no fun, maybe offer some counseling services on the spot as an alternative, and if you're still determined to get some, you can fill out a form and get a card with your face on it to present next time.

Note that this isn't the same thing as a prescription, where a doctor is gatekeeping access to the medicine / drug in question. It's an approach which acknowledges legal drugs as less harmful to users and society than the alternatives, and stresses harm reduction for everyone and ending addictive patterns for users who are able and willing.
Granted. Like I specified, I talked about broadband there.

He preferred to wait all the time until images are loaded to start reading articles, with a flaky slow connection, or to try start reading while parts of the site still load? Especially on a slow connection not having to load the images immediately, or at all if the visitor does not scroll down as much, can make browsing so much better.
Lists of Disasters
Presumably less than the value of the building and server racks.
I think the problem would be the partitions, perhaps try the whole drive end to end next time?
a) Bitcoin price is extremely volatile, even on a 6-month time horizon, and IMO, given the volatility, this bet is a pure casino play: most of the rationale he puts forward has absolutely no reason to come to fruition within the next 6 months. The OP better pray he's not going to urgently need the money he parked in those puts any time soon.

b) On a longer (years) time horizon, historical trend is telling a clear story: shorting Bitcoin is a very dangerous proposition.

Whether you are long or short on Bitcoin, only play with money you can afford to lose.
Medium badger popular writers into becoming "promoted authors" while hiding behind weasel words the fast that means "behind our shitty paywall".