skysight-inc/HackerNews huggingface dataset:
Co-creator of Optery here. Thanks for the good vibes.

The data broker industry is large, and there are hundreds of players across different sub-categories (e.g. people search, email, phone, audience targeting, geolocation, past purchases, TV content viewed, data enrichment, identity graph, etc). Personally, I worked in the audience targeting sub-category for delivering personalized online advertisements. I left the space ~5 years ago when I left Oracle Data Cloud (BlueKai). What we did was anonymized audience targeting for large consumer brand advertisers (i.e. not people search, email, phone, nor anything PII based).

A lot has changed since I entered the space in 2011, and indeed, since I left the space in ~2016. Data has become more weaponized, data brokers have become more brazen in the liberties they take with our data, and the ends they’ll go to circumvent consumer preferences and even privacy laws. Fortunately, a lot of progress is being made. People are becoming more aware, stronger laws are getting passed, technology is being put to better use, and privacy tech is emerging as a more important category.

We felt like we had a lot of inside knowledge of how the industry worked and felt called to put that knowledge to work helping people. This is why providing a Free Basic account that provides a lot of value for free was core to what we wanted to do. Trust is earned over time and we have a lot of work ahead of us given the distrust so many bad actors have established with people’s personal data. We are a new product and company we’re working hard to build trust with our users and customers every day.
Not only that, but the people who most need the assistance are also the likeliest to have trouble jumping through all the hoops. I used to work for a nonprofit who would administer these patient assistance programs and after a while I felt like I was just getting a lower wage for being part of what was clearly mostly a service to for-profit companies.
But how would they punish it if it becomes legal to gather in your front yard and inject methamphetamine?
The Parity Bitcoin client, written in Rust
> I keep hearing about lawyers, but who exactly gets sued?

Whoever arguably had an unfulfilled duty. I’d say the condo association and its individual officers (who would have received the damage reports and arguably failed in their duty of care to owners and indirectly renters with regard to them) would be a good candidate. For renters or their families, their individual landlords would also be potential targets.
What’s the effect in the aggregate on the average person? It seems to me that many (most?) don’t have the willpower to really make smart choices with it, and default to watching cartoons and eating snacks.

We’re watching this happen to a friend of my BIL now and it’s hard to watch. To be fair the kid’s problems started with his parents exercising “choice” to pursue serial marriages instead of raising their kid, but smoking pot (with a blow torch apparently?) isn’t helping.
You say "can" but they "have"
You're lucky if they settle for that and don't want all your bank statements.
You could try to become a respected expert in learning then? There is a lot of use for people who can pick up XYZ in a timely manner. Especially in software where the world moves so fast (unless you do C or similar) that yesteryears knowledge is outdated this year.
You're presenting this like it's a secret thing that lost private keys are irrecoverable.

It's not a secret. Immutability is one of the key features and regularly advertised part of the system. So much so that when that irreconcilability is violated (e.g. rolling back the DAO hack in Ethereum) it's seen as a negative.

There might be some morons who didn't do any research before investing, but they won't be a huge loss if they sell out and stay out.
To be fair, Windows 10 has been surprisingly satisfying in ways that I never imagined. Sure, Explorer still lacks tabs and a real bash is nonexistant, but macOS has gone downhill in other aspects anyway. I have an early 2015 MBP and I loved it. In fact, I loved it so much that every time it threw a problem at me I tried to find a workaround and fix it, even though I could easily switch to my Windows laptop. But the sheer number of problems that required weird workarounds ruined macOS for me. From simple problems like Bluetooth interfering with Wi-Fi and causing mouse cursor lags, to the OS not being capable of driving my 2k external monitor as fast as my Windows machine. At one point, I just said enough is enough, and switched back to Windows after 5 years. None of those problems exist on my Windows machine, and if anything, I've come to appreciate the effort MS put into creating a rock solid OS that just works and is not limited to any specific HW.
you should see what sugar does. I think sugar is even worse than alcohol. We put that shit in everything and our kids are addicted to it by the time they are 5. it's ridiculous. but... weed! think about the children!
Pretend it doesn't exist and double and triple down on everthing that led to the problem?
Or, in this case, not locked
The thing is that there are programs in place right now for addiction but people who are hooked on meth don’t want that help. Maybe it’s because I grew up in Meth country and saw more than half of my childhood friends end up in prison or in the streets because they’re hooked on the stuff. Maybe it’s too close to home for me to be reasonable about this but I’ll never agree that meth or heroin should be decriminalized.
Call me cynical but I don't think that's necessarily seen as a downside by the people in charge. It lets you have it both ways to technically offer assistance that many people find too difficult to actually get.
No it does not. Tether dollars are not backed by real dollars or fairytale "customer deposits". They print Tethers and use them to pump bitcoin price to draw the attention of people like you (and me)
Good for them. I wish it was available when I was taking classes in college.

I wish they went deeper in the grammar and explanatory material - the boring things that make a language work. :-}
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You mean before Robert Moses and the other 1930s progressives ruined our cities? I think it would have been great!

And I say that as a massive car buff, who cant help himself doing 70 on 40 mph country roads slamming the gear shifter up and down through the curves. I love speed.

Cars ruined America’s cities.
It's not anecdotal to point out that so many places have and continue to have record breaking temps for a record breaking number of days. That's not cherry picking anything.
Simple answer. No third party cookies.

And no JS. ;) /jk
I agree with you. But I think there is nuance. When I hear “crypto is good for crime” I hear “crypto is good for all criminals” (where “criminal” is anyone conducting an illegal $$ transaction).

In your process, my statement was 100% talking about the “customer” steps. You’re right. But, at scale, it’s hard to conduct any crime that doesn’t leave a record. At the many millions of dollars of revenue scale, I could see crypto being a trade-off conversation.

> Public ledger cryptocurrencies are able to be digitally transferred without any form of personal identification, unlike almost any other form of payment.

Absolutely correct. But for any crime I’d likely commit, I’d be operating at a scale where anonymity would be hard to achieve. For example, I’d be hard pressed to acquire Bitcoin in a way that didn’t associate the wallet with my identity (if you have methods, please share!). For most transactional crimes I’d likely commit, I’d substitute “show up with cash for crime” with “show up with cash for Bitcoin, then use Bitcoin for crime.” It seems like an extra, unnecessary, step. Cash is already a record-less value transfer system.

> Further, this point is completely nullified by the fact that there are private ledger cryptocurrencies

I’m not sure if we are arguing semantics on this one. But my understanding of tech like Monero and ZK-snarks is that the ledger IS public, but it’s a bunch of locked boxes. Without the keys you can’t see the contents of the ledger. But now you’re in a race against time between implementation bugs (or broken crypto) and the statute of limitations. It’s not enough to audit it yourself. You’re not betting that _you_ couldn’t break it _today_, but that _no one_ will _ever_ break it. The incentive model seems broken. My crime may not be of interest, but I’m committing the transaction to the same ledger where nation states may have interest in decrypting other transactions. I can’t “uncommit” my transaction if the crypto falls to a nation state; my private business becoming public will just be collateral damage.

At a small scale, I’d much prefer taking a one time risk of conducting a no name cash transaction.
Imagine if the building was not in a wealthy neighborhood. Most news would focus on the contractor being racist and how dare they take their lives of underprivileged communities.

As long as the building is in a fancy neighborhood, this is not big news.
Anecdotal, but here are my 2 cents:

> You’re Giving Up Mentorship

Depends on what you want to learn. If you want to learn how to run a startup or how to take on a lot of responsibility early in your career, the mentorship you can get is top class.

> High Breadth but Little Depth

Whats stopping you from building depth? There are plenty of highly focused and specialized startups. Between this and the mentorship point it sounds like author isn't the best independent learner.

> You’ll Work Hard Instead of Smart

The pay won't be FAANG level, but find the right startup and the true 9-5 culture is there. If you aren't "working smart", that's on you.

> Your Equity Is Worth Nothing

Yup. 100% agree.

In summary, here is my 2 cents:
Just like leading a team or working on core technologies, working at a startup is high leverage due to your ability to set standards when it comes to culture, development practices, organizational policy, technology, etc... If you don't care about that, don't work at a startup. If you do care about that, weigh your options.
I mean in many cases the product is still profitable for them at the reduced rate, but why settle?
i'm very hesitant about legalization of heroin. i think there could be a time in my life, if i'm low or anxious, where i would go buy some. and then it'd be likely i'd get hooked for life. there would be many people like that. i think it should be prescription based if anything.
That is what I thought. I sent this picture of a bridge carrying I-95N to MassDot a year ago:

https://imgur.com/gallery/ZSMg1pZ

They cleaned up the chunks of concrete that had fallen from the beam.
So here's an out-of-left-field question. Given what we've been saying for a while, that a Facebook user is not the customer but the product, then how would you ever prove Facebook was a monopoly the way we think of it? Is social media a "market" if no money is changing hands? The market Facebook is actually in is advertising, so you would have to prove they have a monopoly on the online social advertising market, wouldn't you? And the customers you'd be protecting would be advertisers.

And what did they accomplish by buying Instagram and WhatsApp? Well, they acquired more, not customers, but raw materials, to sell. Seems like anti-trust is the wrong way to go about it.
It's supersad to me that in 2021 this subject is controversial. I think the "war on drugs" charade has gone long enough and it's time to actually do the right thing. Stop targeting minorities with this stupid war and legalize ALL drugs. Period. Offer rehab programs + make sure that whatever is on the market is safe and the effects are well documented and understood.
Many people don't want to work.
13 days later, but better late than even later.
Duolingos website actually has different features (and less/no ads for the mobile version of the website). On iPhone you can export the website itself to your home screen and it’s essentially an ad free version of the app with better features. I found it to be way more enjoyable this way
That was covered apparently in April.

https://www.wsj.com/articles/miami-area-building-collapse-co...

> The president of the Champlain South Towers condo association told residents in April their building was in desperate disrepair and urged them to pay the $15 million in assessments needed to fix structural problems, in a letter reviewed by The Wall Street Journal.

> ...

> The purpose of the letter, dated April 9, 2021, was to explain to residents the worthiness of the construction projects for the 40-year-old building ahead of the following week’s meeting about a proposed special assessment of $15 million to be paid by residents.
That right there is your manager projecting their fear onto you.
Hopefully your manager has noticed and you'll have a chat. If you trust each other, which isn't a given, tell them what's going on.

Especially during the pandemic, I've had people go through varying levels of productivity. Maybe it's depression, boredom, personal stuff, burnout, whatever. We're human beings.

I've been allow to institute mental health days - if the month doesn't have a (US) federal holiday, book a day off. If you're really burning out, let's see what we can do about that - also involves time off.

Depending on what area you're in (I'm in devops), it costs probably 6 months of your salary to replace you, plus it's hard, and all your knowledge leaves with you. Plus people remember when you back them up - it means a lot on a human level.

It's been done for me and I do my best to pass it on.

Good luck.
Yes! I had those as a kid. It was like mazes that kept getting harder, like I had to find a solution but can’t. Very unpleasant in a way that’s hard to describe.
I agree and I also don’t consider there to be a competition right now.

I would like their program to share data with the world. The more the merrier!
I came here to post basically this.

And thinking on what you just wrote, it kind of feels like that is exactly what we’ve been doing with social media.
It works like this everywhere in the world. Humans are...humans
"Our extreme positions are just these cherry-picked sunshine and rainbows."

"That's a dishonest framing, given you're neglecting this murderous position, that race essentialism position, and--"

"Sunshine. And. Rainbows. :)"
Generally speaking, I think two things went wrong here.

1. Almost anyone seeing all the warning signs probably didn’t think an entire building could collapse or partially collapse. Things could look terrible, but maybe not enough to say, “I need to get out of here before this building collapses.” Yes, that is said in old building and homes but it just doesn’t compute in building this size. That is why a professional inspector needed to be involved.

2. Time was also a problem here. In the US, a modern city with a 40 year old building just doesn’t compute. It’s actually kind of old in the US, especially with problems like this. Similar to #1, it didn’t compute a building this size could collapse this way. That is why a professional inspector needed to be involved.
“11” + 1 = “111”

“11” - 1 = 10

(ノಠ益ಠ)ノ
No, those are technical issues.

The social issues are the loss of control over our motor vehicles like we lost control over our smart phones.

The car, and the freedom it gives, was a crucial player in the release of the Pentagon papers. With enough IoT tech that wont exist in 10 years (anywhere, nvm cars)
tl;dr on their financials and growth?
The Web wouldn't be a reliable "web" if that behavior were widespread.
Public transit, walk, bike, ...
Nobody bats an eye if you can't get somewhere easily by public transit but the prospect of not being able to drive somewhere is incomprehensible?
> Independent media across the globe and across political spectrums have reported that China has locked away >= 1M people in concentration camps.

"Independent media"
It’s in a tunnel now, kinda a big deal for a long time. The TBM got stuck and stuff
It sure as hell impacts me when I am paying for the 10th dose of naloxone to be slammed into you in a row if you are a repeat ODer.
I don’t know. That’s why I’m asking.
So did Instagram employ these fuck-you patterns from the start, or did they pretend to be friendly until they'd gotten enough market share and network effects?

That's called bait & switch, and is (if not legally in this case, then morally) rightly considered fraud.
I like your train of thought and understand the uncertainty that both avenues present. Personally I believe that healthy adults will mostly choose to avoid getting addicted to hard drugs as long as they’re aware of the consequences. To achieve a reduction in the harm that drugs have in society I feel that we need to do everything possible to reduce the number of new people getting addicted while also making it easy for people to receive treatment and bring them into a system designed to get them back to health. Problem is that doctors need to be educated on this as well. That means stopping doctors from pushing pain pills that get people addicted to pain meds in the first place (because who in their right mind would go straight to using heroine if they hadn’t started on prescription pills) and encouraging open discussion with youths that’s focused on education instead of pushing an agenda (admittedly this doesn’t seems possible) while also legalizing methods for people to access hard drugs in order to bring addicts in out of the cold so to speak and expose them to a medical system that encourages them to get their health back.
When it's not very well aligned to your argument, it suddenly becomes irrelevant, very convenient.
Good point about supervisors and middle managers (or rather low managers).

I think it is possible to have 10 effective supervisors, but not 1000. 50 of these 1000 start making subjective decisions (based on sex, race, having hungry children and other prejudices), and the whole system will start working much less efficiently than ML, and it will be worse for both Amazon (worse quality) and hard working delivery men (being fired because of supervision misjudgment).
If you deceive someone by wearing a different face during an interview, I expect that you would not be hired. How do you prove you were the person interviewed?
that's your opinion and it's okay to have that opinion. My opinion is that the government should not tell me what I'm allowed to do with my body (or even worst arrest me for doing stuff to my body). If I literally want to kill myself it should be my choice - How ridiculous would it be if we arrested people that attempted suicide? It's at least as ridiculos trying to end up in prison for an addiction.

Also, completely tangential. But poverty is the thing that really kills people (including driving them to seeking the thrills of hard drugs). I can almost guarantee that there is a correlation between income level/standard of living and meth zones.
A cofounder war led to everyone quitting Instagram's trendiest cookware company
What IP though? Humalog is off patent. It now appears to be just red-tape or collusiom.
Also part of a bird's abilities is the ability to detect polarized light. It seems to work with the ability of birds to detect magnetic fields.

See for an interesting read: https://www.pnas.org/content/113/6/1654

Many or maybe most humans can also see the polarity of light. Take your smart phone and make the screen display a white image. While it shows this image for a long time, rotate the phone. You should see a yellow whispy checkerboard pattern turning with the phone. This "brush" is actually a visible measurement of the polarity of the light coming from the phone.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4528539/

I don't know if there's any mechanism for which humans can detect magnetic polarity, but there's research on this too:

https://www.the-scientist.com/news-opinion/can-humans-sense-...
transgenic E coli is easy, not sure what you think is hard.

Insulin, though is possibly one of the most nightmarishly difficult proteins to make. It's kind of astonishing to me that Insulin was both the first protein sequenced and the first pharmaceutically relevant protein synthesized. Mother necessity, I suppose.

Genentech started making separated-chain insulin in E coli, back in the day, and that is emphatically not how it is done today. You get a whole bunch of crap because you need to keep the two chains denatured, and that results in scrambled disulfide bonds. If you try to do it in protein-folding conditions, one of the chains crashes out into plaques structurally similar to alzheimer's plaques.

You could make it as a single-chain protein, and then cleave out the middle section, except that the protease that you would use to cleave it out has another site internally!! And all of the proteases which leave a "clean end" leave a "clean end" in the wrong direction to yield a good insulin molecule.

Industrially, insulin is made (in yeast, not E coli) by going ahead and cleaving at that extra site, and then performing a reverse proteolysis to install a synthetically generated peptide, restoring the molecule. That's also why most insulin variants (e.g. humalog) have mutations in the tail end, that's the part that is "reinstalled". Note how crazy this is. Proteases are usually used to break proteins apart. Although technically all chemical reactions are indeed reversible, to force the chemical reaction in the other direction, you're fighting entropy, to put humpty dumpty back together again.

Honestly OIP's best shot is probably Michael Weiss' one-chain insulin molecule, which should have gone off-patent this year (https://patents.google.com/patent/US8192957B2/en) (15 years, right? IANAL) but for some reason got extended to 2028!!

However, the big danger with insulin analogs is that you really need to test the F out of them because insulin cross-reacts with the IGF-1 pathway and cause cell hypergrowth = cancer. I would also be very careful with home-made stuff because I would need to be convinced that the forumlation whipped up doesn't change the properties in such a way to to increase IGF-1 activation.

I advised Open Insulin on a ton of stuff in the first few months, but they took literally none of my advice on anything, and last I checked their mailing list a few years ago they were still stuck on some stuff I warned them about (e.g. insulin doesn't stain in coomassie blue -- another thing which makes insulin a pain in the ass).
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As enby and trans, I've voted your first (edited) and second comments back up.
Does it really impact you though?

Is our medical system so well tuned that people receiving a procedure that literally saves their lives is inconvenient for you?
Yeah there’s no way hard drugs should ever be easy to access. Putting them behind a prescription that’s required to be administered in a controlled environment seems the obvious choice. Honestly it should be safe, legal, and rare
Or the old Champlain
> Where is the line for something like the lab leak hypothesis?

Recent history seems to have an answer - thats off limits until it fits the narrative!
The condo association officers are likely volunteers, elected by the condo owners, and indemnified by the association. They are just homeowners like everyone else, unlikely to have any expertise in engineering or understanding engineering reports. And possibly also now dead.
The companies that buy ads are vain and obsessed with cultivating a brand image, and Google is more than happy to indulge them. It doesn't matter that nobody is actually going to get outraged and stop shopping at (e.g.) TJ Maxx just because a game streamer said the word "die", it only matters that TJ Maxx bought the ad and the managers can be reassured that they've mitigated their risk.