skysight-inc/HackerNews huggingface dataset:
Unfortunately medical experts are not allowed to discuss this in public, so we’re left with back door meetings where Pharma execs will inevitably push outcomes that will be favorable for their bottom line.

Who wants to invest billions of dollars into a new vaccine/anti-viral drug only to lose out on all that investment by Ivermectin which will not contribute a single cent to the Pharma execs year-end bonus?
The Peewee Herman show was a fond memory of my childhood, and I tip my hat to everyone involved.
I was more meaning within the therapeutic window, but you are quite right of course.
Dexamethasone is off patent, it's cheap and widely available, it's also the standard of care for covid-19 patients on respiratory support.

What's the difference between dexamethasone and hydroxycholoroquine/ivermectin/next-consipracy-theory?

It's been proven to work. There's no conspiracy, just pharmacology is hard, and people's random hunches typically don't work out.
Thanks for sharing your expertise. Would you be open to sharing your background? Obviously it's not required, but it would help contextualize what you're saying for the interested non-mathematician; otherwise we're kinda stuck with 'some guy on the Internet said ...' syndrome. :)
Yes: don't.
Unless "e-branded" means hybrids? Hard to tell.

edit: OK sounds like "e-branded" might also include things like the "Audi A3 TFSI e" which is a PHEV
I'm not sure why crypto is even relevant here. If Bitcoin drops to zero tomorrow, the economy won't budge. The real thing is the moratorium on evictions expiring this month, and with about 8 million americans haven't been paying rent and mortgage for a while, this opens interesting possibilities in July. My bet, though, is that the moratorium will be extended till end of year.
Hi Peter, thanks for dropping by!

Quick question: what if my start-up focus on psychedelic research [1]? Will I run into problem with immigration? (Considering that substances like psilocybin is still schedule one)

Or what if my start-up is not about psychedelics but I have written & published books/papers on psychedelic? What about just blog posts?

[1] say similar to ATAI (founded in 2018) that went ipo yesterday
Never said it's not worth studying. The methodology, resulting samples, one-sided nature, and biased and opinionated narrative structure of the paper (I urge you to read through it) make it entirely uninteresting is all.

It's clear that this is yet another piece to throw on the libertarian heap and to spin it into anti-woke agitprop just as the OP (and linked tweet, to a lesser extent) did with their heavy editorializing. Fuel for the fire for everyone who wants to read the title and extrapolate some greater social trends from this to fit their already established perspectives.
Otherwise GRUB, which boots Linux, would force your entire OS to be GPL. Worse, GRUB can boot Windows when dual-booting, and because Windows will never be GPL, GRUB's ability to boot Windows would be a GPL violation. The bootloader on the Prusa Mini is basically GRUB in this case.
The greater the military budget, the more you have to justify it.
You are seriously proposing that if an effective treatment had been found in 2020, that the US government would have denied EUA for vaccines while the rest of the world got to work vaccinating their citizens?
> "quiet ride" - I've never once in my life wished that the interior of my vehicle was quieter, this is such a superficial benefit to consider.

This is for me the single biggest reason I will never go back to an ICE car, after driving a Model X for 4 years now. My wife drives a small petrol car (Renault Clio) and I hate the sound of the engine so much.

Do you have experience driving an electric car as a daily? Or just countering all arguments as an exercise?
The thing is, Audi is just one brand that is part of the VW conglomerate. Its their luxury brand, just below their Porsche brand.

They could easily turn Audi into their Tesla-competing luxury brand and have it pure EV, while still having VW (and Skoda in Europe) pump out ICE vehicles like crazy, and impact nothing in terms of overall CO2 emissions.
No, sorry. The linked study suggests a 60% reduction in deaths from this drug. Even if it were true, it is nowhere enough to be an adequeate alternative to the vaccines, that were both vastly more effective at reducing deaths and could also significantly reduce transmission.
A number with a question mark behind it is not evidence, and even if hundreds of doctors did speak up about it, hundreds of doctors thought Cholera was caused by miasma instead of bad drinking water. Hundreds of doctors thought bleeding was the universal cure all. Hundreds of doctors thought washing their hands was useless. Some random number of random doctors saying it may be effective is not evidence of it's effectiveness.

Your document also doesn't say what you think it does. If it did, we wouldn't be able to have multiple vaccines approved. Is there any evidence that the FDA would interpret a non vaccine as an alternative to a vaccine, when there's no issue with granting EUA to multiple vaccines? I doubt it, but would love to see what you have.
Music has many different concepts at play, some of which are easier to conceptualize geometrically than others. Waveforms are one, but another visualization that resonated (pun semi-intended) with me was to visualize triads in three dimensions by plotting the pure sine wave of each note of the triad on its own axis as a function of time.

When you plot triads like this, you immediately see that the more harmonic a chord is, the visually simpler its graph is. This is unsurprising to anyone who knows the basics of the math behind music (simple ratios = harmonic, complex ratios = dissonant), but it's striking to actually see it drawn out like that.

I definitely would not say music is one-dimensional. Whether you're considering the interplay between intervals, the movement and manipulation of various emotions and motifs in a piece, or whatever, maybe the thing that strikes me most about music relative to other media is its arbitrary dimensionality.
You can use a petrol generator to charge your car for your super edge case that 99.99999% of us will never have to worry about
I used to do this. It broke too often when doing credit card purchases though... it would take multiple attempts to complete a purchase and figure out which domains needed to be enabled. Sometimes the status would be left ambiguous. Once I double-spent, but fortunately it was a cancellable reservation. I suppose you can do better if you just spend at a few key sites.
Thanks for correcting me, meant to say dihydrogen monoxide, aka water ;)

My point being that you can over-dose on almost any compound at high enough doses. So instead of driving the conversation underground and letting patients self-medicate, we should empower doctors with proper information rather than painting Ivermectin as a conspiracy theory drug
love it!

is there a Sunset Commission for the Sunset Commission? :-)
Thanks – good to know!
Maybe Apple will spin off desktops and laptops as a "pro" or "business" division or company, as HP did.
> doses up to 100-fold higher than those approved for use in humans.

Drugs are approved according to their use. If they have multiple uses, they will have multiple approved dosages. Someone with sudden sensorineural hearing loss might be prescribed 60mg of prednisone per day, while someone who takes it for rheumatoid arthritis will take only 10 mg per day. One dose is six times the other dose. Both are safe, and both are approved.

It's also necessary to consider the drug's therapeutic index. Therapeutic index is a ratio that measures the difference between the effective dose of a drug and its lethal dose. [1] NIH data indicates that administering ivermectin (at these "100-fold higher" dosages) to treat COVID-19 is no more dangerous than placebo. [2]

1. https://en.wikipedia.org/wiki/Therapeutic_index

2. https://pubchem.ncbi.nlm.nih.gov/compound/ivermectin#section...
Yes, they are for YC startups only. (When in doubt, its always best to email the mods about such things though - contact link is in the page footer)
I know, it's shocking. According to Volvo's own statistics something absolutely insane like 70% of all owners never even plug them in. You should lose the tax exemption entirely if you do that if you ask me. Funnily enough I didn't get any tax benefit as it was a private purchase, but here in UK if you buy it as a company vehicle the taxes on it are very low(used to be zero I think).
Not at all and quite the contrary; mention of an article that you wrote in a publication gives credibility/weight to the article.
> The PRC is China and Taiwan has been a part of China for over 100 years.

I think this is not factually accurate. In the last 100 years, Taiwan and Mainland China have been controlled by the same government only between 1945-1949.

China (Qing Dynasty) controlled Taiwan for ~220 years before losing it to Japan. Japan ruled Taiwan for ~50 years. RoC ruled both Taiwan and the mainland for ~5 years before losing the mainland in the revolution. (Edit: RoC has not ruled the mainland for ~60 years, which is almost twice as it ruled the mainland.)

I think you are correct that no draft would be instituted. We have plenty of military assests that certain people would love to justify the maintenance of so there would absolutely some fighting by US personel on behalf od Taiwan, regardless of how smart or winnable that war would be.
> Why should the government do that?

Free-market dynamics require a lot of intellectual overhead.

For example, in a theoretical world with unbound computation and information-sharing, all stocks on the stock-market should be perfectly priced, and all doctors should be of known qualities. And all of those supplements in the pharmacy should be of known effect, and priced perfectly given that knowledge.

But in more limited contexts, where folks don't have infinite free information and computation, centralized authorities can help provide standards. For example, if you go to a licensed medical-doctor, then you may not know their exact quality, but at least you can generally infer that they're competent enough that the state hasn't yanked their license. Ditto for most other licensed professions.

Anyway, to answer your question: the government does it because it's too costly for everyone to do it themselves. When that changes -- this is, when consumers start to acquire a level of knowledge where they can make informed decisions and find government regulation stifling rather than helpful -- then they petition the government to change in response to such new circumstances.
It's impossible to be an expert in every field, particularly those as complicated as medicine. Furthermore, you don't have to rely on authority, I linked to an RCT showing it was ineffective.

"Not particularly profitable", which is speculative, is still profitable. I highly doubt any one at Merck is actively working against selling a drug they already manufacture at a profit, but feel free to provide evidence otherwise.
"everybody in the world is benefiting"

Did the patent issues get resolved? Last I heard, the drug companies didn't want to share because of reasons.
How can this be relevant when Texas has exactly the same issue about the term 'engineer'?

More specifically, 20 years ago I remember learning Texas had some of the strictest laws on using the term "engineer". You could not call yourself a "software engineer" in Texas if you have were been licensed by the state. https://www.chron.com/news/article/Law-to-decide-if-programm...

Now, my knowledge is 20 years of date, and Texas law appears to now allow "engineer" in a business card of a software engineer[1], but my point is that the Texas Board of Professional Engineers would be the one to determine things like this, and I see no way that that board (a "self-directed semi-independent agency of the State of Texas") would be discontinued under the Sunset Commission.

Therefore, I don't see how that mechanism could be use to cut down on this specific type of abuse.

[1] The current laws are at https://engineers.texas.gov/downloads/enf_pub.pdf .

> Except as provided by Subsection (f), a person may not, unless the person holds a license issued under this chapter, directly or indirectly use or cause to be used as a professional, business, or commercial identification, title, name, representation, claim, asset, or means of advantage or benefit any of, or a variation or abbreviation of, the following terms:(1) “engineer”;(2) “professional engineer”;(3) “licensed engineer”;(4) “registered engineer”;(5) “registered professional engineer”;(6) “licensed professional engineer”; or (7) “engineered.” ...

> (f) Notwithstanding the other provisions of this chapter, a regular employee of a business entity who is engaged in engineering activities but is exempt from the licensing requirements of this chapter under Sections 1001.057 or 1001.058 is not prohibited from using the term “engineer” on a business card, cover letter, or other form of correspondence that is made available to the public if the person does not: (1) offer to the public to perform engineering services; or (2) use the title in any context outside the scope of the exemption in a manner that represents an ability or willingness to perform engineering services or make an engineering judgment requiring a licensed professional engineer.

It looks like (f) was added 20 years ago, and it allows someone to say they are a software engineer on a business card. Exception (f) does not allow a non-licensed engineer to say they are an engineer when an expert witness in a court case.
Why would it make sense for audi to continue selling gas cars due to a surcharge? Presumably it is already not economically viable already
That trope needs to die. California's schools are not underfunded. California spends a record amount on education[0], over $18k per child.

"Reflecting the changes to Proposition 98 funding levels noted above, total K-12 per-pupil expenditures from all sources are projected to be $18,837 in 2020-21 and $18,000 in 2021-22—the highest levels ever (K-12 Education Spending Per Pupil). The decrease between 2020-21 and 2021-22 reflects the significant allocation of one-time federal funds in 2020-21."

[0]: www.ebudget.ca.gov/2021-22/pdf/BudgetSummary/K-12Education.pdf
Alright. I’m glad I asked, even if my phrasing sucked, because it uncovers why they’re doing this.
> I am not in favor of flat out banning such books (even if I personally believe they have no place in an environment of science and learning such as a university)

In society’s most important institutions of science and learning, ALL ideas must be open to scrutiny, especially unpopular ones.

Shouldn’t we want society to be built on the bedrock of truth via scrutiny, rather than on the mere sand of intellectual fashions?
Imagine in 2021 thinking HN would be positively receptive to someone boasting about choosing a $75k S6 ICE, polluting over the next 20 years at 22mpg, over an EV. Money is not an issue and yet there's no mention of climate change, only that it was a "no-brainer."
Sure, I just created an account a couple of days ago, and my favourite username was already taken :oops:

I'm Johan Commelin, https://math.commelin.net/
Phaedo
Azuracast is a free and open-source self hosted web radio management suite
The electric F150 Lightning puts out over 500hp, and I think the Cybertruck is expected to as well. Are these vehicles also comically impractical?
From a technical standpoint, it is the same. The phone maintains a connection to a Google server and listens for "authorized" installation requests - where "authorized" means "authorized by Google". When you click "install" on the Play Store on your laptop, you're not talking directly to your phone (how would that even work?) - you're talking to Google, who then speaks to your phone on your behalf.
The Audi e-Tron CCS implementation is apparently really bad at talking to charge points. Just because it won't work for your car doesn't mean it is broken. The car itself is deficient.

Glad you are otherwise happy with the car. I went electric nearly three years ago, and it has been great.
All you need is a smartphone app for that.
> checked out by someone qualified to check their skills

Well sure, we'd all like that. But those of us who have experience dealing with government regulatory bodies (even justifiable ones like building inspectors, fire inspectors, etc.) are skeptical for good reason. The competence of your licensing overlords will vary greatly.
I really dont like FB services
Semiconductor fabrication is almost entirely automated and any new fabs in the US will be on the cutting edge of new automation technologies, so I don't think there will be quite so many workers involved.

It's also rather specialized labor.
Urbit for Mathematicians
I see these immigration AMAs as a service to the community. They are among the most popular threads we've ever organized on HN, maybe the most consistently popular. If Peter gets business out of it, that's reasonable—why shouldn't it be a win/win?—but from an HN point of view it's a side effect.
It doesn't sound like particulary clever malware to me. It sends a filename to some logging service, then opens the windows hosts file and adds some lines to it. And it's only run because the downloader thinks it's some pirated software or keygen.

Not to say there aren't some folks wasting time on more clever malware.
that I've never had an alert from it despite living in a region with high covid incidence has been reassuring.

Hm. Mandatory XKCD: https://imgs.xkcd.com/comics/tornadoguard.png
So if you have these skills or interests, what should you do with them?
They’re not very fuel efficient are they?
I have watched his shows. Intellectual alt right is a quite suitable label for this guy.
You used the perfect example. Filipino cuisine is not popular anywhere in the world even if Filipinos emigrate in large numbers. Is it possible that more Chinese people emigrated and opened shops whereas most Filipinos worked as employees or nurses? Could that have been the reason why? Maybe Filipino food doesn’t look as good as, say, Thai? Vietnamese? Japanese especially?

I’m looking for answers.
> Many if not most universities are publicly funded quasi governmental institutions.

That sounds very much like someone whose only experience is with large public universities. I don't really know what "quasi-governmental" means, but any reasonable meaning I can assign it is far beyond my small university--and there are way more small universities than big ones.
It sounds like an ICE vehicle is the best fit for you, but also that your needs are quite unique. 99% of even SUV owners are never taking their vehicle backcountry anywhere. A dirt parking lot at a redwoods park an hour out is the most off grid they’ll ever get.

And the acceleration and quiet ride are nice. It’s just one of those things you don’t appreciate till you have for a while. Like backup cameras.
Better that they sell their souls to corporates the usual way.
Methane decays relatively rapidly.
I don't think either should cause a problem. Manufacturing or distribution would be different.
Just once, loved it!
Psychogenic fever: how psychological stress affects body temperature
"on a backcountry trip in the desert ... strap on extra gallons of fuel" -- Since you are going into a desert, would a portable solar charger work in place of extra fuel? The downsize is that it is only usable in daylight and it might not be able to charge fast enough, but solar panel is not flammable like gasoline so safer. It is probably more realistic to have solar charging stations in desert, independent of electric grid; at least we don't have to run wires into desert just to charge cars.

Smooth acceleration will help prevent someone getting car sick. Similarly, absence of car exhaust helps, too.
My hunch is it comes from companies that use PMI project managers. Maybe that maps to older non-tech companies, but I have no proof to back any of that up.
Hmm, thanks!
https://sebastianrushworth.com/2021/03/04/hydroxychloroquine...

Two observational studies, both carried out in New York (Carlucci et al. and Derwan et al.), appear to show promising results in patients treated with a combination of hydroxychloroquine, zinc, and azithromycin. The first, involving 932 paitents, showed a 55% reduction in relative risk of death among those getting zinc in addition to hydroxychloroquine and azithromycin, as compared with those just getting hydroxychloroquine and azithromycin. The second, involving 518 patients, showed an 80% reduction in relative risk of death among those getting the full triple therapy, when compared with a reference sample that didn’t get any of the drugs.

That seems impressive. However, these are low quality observational studies that are seriously limited by the methodology used. The scope for confounding effects is huge. Therefore, these studies should be considered exploratory and hypothesis generating. They certainly should not be considered evidence of any cause and effect relationship.
In the embedded world, software can absolutely destroy hardware in all sorts of ways. I've done it many times.

Loading untrusted firmware onto a PCB with high current outputs - like motor control - should absolutely void your warranty (for that PCB and anything connected downstream of it).
Yes something about the ev driving experience is very compelling, it's easy to see now that it's the future
Smooth acceleration is due to no gearing, which means no transmission. Which goes into the next point about maintenance. ICE cars are extremely complicated due to how they transmit power to the wheels. 90% of this is eliminated in electric cars because the motors are at the wheels.

And it's a lot easier to capture pollution at the source of centralized power generation vs hundreds of million of cars, but I am just stating the obvious here.

If anything, your "counter points" -- while acknowledging the tech isn't perfect, are actually making a strong argument for electric cars.

As far as gas vs electric infrastructure it's genuinely perplexing that someone would argue for the former over the latter. For one thing, electricity is a lot more useful than gas! It's also safer, easier and cheaper to transport.

It also exists basically everywhere, even if the current infrastructure is not up to spec, you can still charge an electric car with a regular outlet with no special considerations.

Every thing you are saying is a detraction is really just pointing out solutions that are still in the early stages, but absolutely will get here vs problems we have just accepted from ICE.
this is actually not as disgusting as it looks.

Most of the food we eat have come to be through centuries of iterations to make it better tasting, safer, easier to preserve, etc. or simply edible.

For example olives taste really bad in nature, to make them tasty there are different ways, including immerse them in a solution of water and caustic soda or water and burnt lime, which are highly toxic substances.

I can't even wrap my head around how someone thought it was a good idea, but however the procedure was invented, it worked and we can now experience the amazing taste of sweet olives.

Or think about meat hanging (dry aging) where meat is aged for weeks before being eaten.
The newtonsoft json dlls (and other) distribution contains different dlls in different folders called "net45", "netstandard2.0", "portable-net40+sl5" etc.

So it is obviously more than just a specification, since binary dlls can target different values of "netstandard" in addition to .net framework and .net core.
If I have an expired visa stamp, is going to a consulate outside the US the only option for an extension?
Err network games deal with latencies in the hundreds of milliseconds.
What's the best secondary reference for immigration stuff in Westlaw or Lexis?
The simplest solution is: $30/tonne CO2 price, and also requiring fossil fuel exporters (including in other countries) to add this price to their exports unless the shipment is going to a country that also has a carbon price.
Music is everything?