skysight-inc/HackerNews huggingface dataset:
Much like cryptography, the science of DNA is good, but the roll-your-own DNA forensics implementations have had issues.

https://www.propublica.org/article/thousands-of-criminal-cas...

https://www.theatlantic.com/magazine/archive/2016/06/a-reaso...

https://www.nytimes.com/2018/09/21/opinion/the-dangers-of-dn...

A quote from The NY Times article:

“The first two suspects’ DNA was part of the mixture, and most labs correctly matched their DNA to the evidence. However, 74 labs wrongly said the sample included DNA evidence from the third suspect, an “innocent person” who should have been cleared of the hypothetical felony.”

There were 108 labs tested. 74 of 108 fingered an innocent person.

As long as DNA forensics processes are open source, we should be good, because the questionable component is the implementation, not the base science.

But, closed source DNA forensics is dangerous, I think.
Cloudflare also provides DNS over a Tor hidden service: https://developers.cloudflare.com/1.1.1.1/fun-stuff/dns-over...
Vitamin D deficiency exacerbates opioid addiction (in mice)
Yes and no. If that's literally allmit does and it doesn't do it to an extreme amount i'd have no issues with it, but it also points to it possibly causing other effects that we need to be looking for and studying so we don;t get caught unaware of it destroying ecosystems that we depend on for our lives too. You have to remeber that we don't exist in isolation drom the environment and if it causes that in fish, it might be causing other problems in us, or in plants and animals that we depend on directly or indirectly.
The only miracle drugs that I know of are sleep, water, and exercise. Even those have dose-related toxicities!

https://peterattiamd.com/metformin-and-exercise/

If you're healthy enough to exercise, that's probably more effective. Apparently (I haven't tested myself, and I don't know how thorough the literature is) metformin lowers your lactic threshold, which reduces the total amount of work you can do in that state.

Do cardio, sleep enough, avoid refined sugar and fats that are solid at room temperature. More than that... godspeed
Non-AMP link:

https://www.theglobeandmail.com/arts/books-and-media/review-...
"Meditate for an hour every day unless you are too busy. In that case meditate for two hours."

- many Buddhist teachers, in many variations.
I have an augmentation of clickup via their api which lets me report in different ways on subcontractors and tasks/projects/clients over different time periods and calculate overall/historical profitability. Works quite nice :)
So you can't run an experiment and tell apart matter in normal time and from anti-matter in mirror coordinates with time reversed?

Because while CP symmetry is violated CPT symmetry always holds as far as we know?
* A word that occurs only once in a given corpus. For example, if you list all the words in a book, it can have many hapax. That usually says something about the diversity of words an author uses. A hapax that is unique to all records of a language is quite rare.
> The difference is that the whole strawberry patch looks the same.

In fact this depends a lot on the location, soil and age of the clones.

> The ferns, by contrast, differ markedly in morphology and reproduction depending on their role in the colony."

First of all, population is not the same as colony.

Second, many plants have auxiliary structures (temporary, marcescent or permanent). The concept of bract, thorn, nectarium or stipula is not a strange one for botanists but those are parts of one individual, not individuals in a colony.

Is well known that gametophytes and sporophytes are different individuals. Many algae and ferns have it. If we want to bend the concepts for non useful reasons, then any pregnant woman should be called an "eusocial colony" with three individuals.
I made https://xbm.jazzychad.net as a simple online XBM image editor for use in various Arduino projects that use those little oled displays. It was also an excuse to learn React a few years ago.
This whole comment section is totally delusional regarding the reliability of medical statistics and preliminary data in life science. It's funny (and sad) to see people easily disparaging "state-of-the-art treatments" be so prone to experiment on themselves with moonshot claims.
Sounds dumb but I go camping a lot and still want to access various informational APIs when I’m in limited cell reception areas so I built a bridge that allows me to hook my APIs up to text messaging. I just send a text like “news” and get the latest headlines over sms. It works pretty well even when I don’t have data access I can still usually get the text messages back.
https://www.npmjs.com/package/bebusy

Seven years ago I needed time for finishing a school project and wanted to look busy at work. The packages prints random messages to terminal, so you look like you are are in middle of some deployment job or npm install.

Still works as far as I know.
I think this is mostly throwing out chaff for PR purposes:

1) They're not giving the money back, or better and less conflict-of-interesty, giving it to a neutral pro-foss org like FSFE

2) They continue to intimately support freenode

3) Fosshost directors remain as freenode staff but in a """personal""" capacity, despite being overruled unanimously by the fosshost non-director staff.

Nothing concrete has changed, the only thing they have done is roll back their desire to integrate more deeply.
Sure, but evidence from last several millennia also show they haven’t kept people healthy quite as long.
Can't claim I knew this at the time (wasn't my equipment) but Google tells me now this required MD Data discs. Normal audio discs would be limited to 2 tracks. Still, seemed nifty back in the day.
Its only recently that humans gained the ability to control the illumination and temperature of their work environment.

Sleeping less would have been of no advantage when you have 8hours+ of night for each 24 hour period anyway.
Why do you assume that the US wouldn't block foreign monopolies as well?
Adjoint functors are mind blowing.
People used to use shell variables like this a lot in (to name one place) alt.sysadmin.recovery, such that the FAQ even mentions it: http://www.faqs.org/faqs/sysadmin-recovery/ (section 1.3)... meaning people have done this for decades.
This reminds me of a question that popped into my mind earlier this year. Forewarning: I’m not a professional physicist.

If the Big Bang didn’t create an equal quantity of matter and antimatter, and given that antimatter is still being produced by various cosmological sources and at a lower rate for proton-antiproton pairs than for electron-positron pairs, would that imply that the universe has a non-zero net electric charge which is still changing over time?

And if so, what would a universe with a significant non-zero electric charge look like?

And if not, because Noether, could the combination of e.g. antiprotons and positrons into anti-neutrons turn out to be stable and one possible candidate for dark matter?

(Full blogpost: https://kitsunesoftware.wordpress.com/2021/02/09/baryon-asym...)
Those so called alternative practitioners lack scientific rigor, I am afraid of, or more likely just do not know what they are doing. Exceptions exists of course.
Recently I released a webapp to fix a problem I faced. I can paste any image from my clipboard (mostly screenshot in my case) to get its base64 version so I can integrate it directly in any markdown: https://paste64.vercel.app/

It was also an excuse to try out Svelte with TypeScript: https://github.com/aloisdg/paste64
You are going to live long enough and be able to reproduce with about the same probability all other things equal whether you need 3 hours or 10 sleep nightly. There's very little evolutionary pressure even if you would massively and hugely prefer one of those over the other.

The kind of non-survival genetics that could be selected for in the modern world are those that make multiple women (nature can be pretty sexist) want to throw caution to the wind and have babies fathered by a man with some desirable attribute. I have no idea if this actually happens in reality with heritable genes. Eg do basketball players pass on a greater than average amount of their genetics (more children with more women) by virtue of being tall making them more sexually desirable to those who might become single mothers? Plausible, I guess, but could easily be utterly false. I don't know how you'd test it even in the absence of ethical concerns.
And rightfully so given the state of the evidence.
The only way to get a reliable answer at this point appears to be a large, randomized trial - the TAME trial (https://www.afar.org/tame-trial) was supposed to have started in 2020. Although the official website doesn't say so, I found various articles in the press from late 2019 which said they had raised all the $75 million they needed for it (for example, see https://www.longevity.technology/worlds-first-anti-aging-tri...). After that, it has been radio silence from them - no website updates, no press releases. Although their website says they have clinical sites set up, I haven't been able to find the clinical trials.gov entry for it. I even sent an email to the PI Nil Birzalai (at Montefiore in NYC) a few weeks ago to find out more, but didn't get a response. Does anyone know whether that trial even got off the ground?
Do more drivers turn right at red lights in the US than in say UK were it is illegal?
>> “It is a good sign in a nation when things are done badly. It shows that all the people are doing them.

That's a great quote to describe the meme stock phenomena.
I was under the impression Apple first party apps could bypass these with special privileges?
Alternately, the rooms can simply be renumbered with no guest motion.
If you think that the trivial differences between the two environments makes either of them useless to learn the other, franky I'll doubt you'll have the skill to learn D3 properly at all.

Taking a dom node and hooking it into the dom is not magic in D3. All that obervable does is hook in any dom node you return for you.
> avoid refined sugar and fats that are solid at room temperature.

This leaves, what, protein and starch? And cooking oil, I suppose, but all forms of meat contain solid fats.
>Really? Distatnt galaxies move away from each other at insane speeds. That seems like a plenty of kinetic energy to me...

US 708 is going fast and it's still only 0.4 percent the speed of light.

if you're talking about relative speeds between astronomical objects being very high due to cosmic expansion, i'm not well enough versed in the physics to know why or explain how, but the energy locked up in that movement doesn't seem as practical to talk about with regards to creating work.

we know how to harness kinetic and thermal energy, as far as I know we're not yet able to surf the cosmic expansion, except inadvertently.
> I don't know what the boundaries of eusociality are

Even my chicken would fit in that description.
What would happen if I swiped my murder weapon thru rack of clothes in a second hand shop?
I had no financial acumen when I first joined AWS, paying little to no attention about granted RSU(s) — I was just so giddy to have gotten at job there. Looking back, wished I learned a little more about the compensation model; up until then, I worked jobs that gave you a salary and that was it. A little homework on my part would've helped me understand the fluctuations in my income over the last few years.
The Wayback Machine tweeted less than a hour ago:

> Part of the @internetarchive's core infrastructure suffered some breakdowns today.

> Engineers are in the process of configuring a backup unit.

> We expect that work to be done soon, and all services, including the @waybackmachine, will be fully restored.
We're talking about a javascript repl here, don't blow it out of proportion. The things transfer trivially between the envionments. If having a javascript repl is such a show stopper for learning D3 for you, maybe learn javascript first.
I never understood this point:

- You have a separate schema for your procs

- You define your procs in files

- You write tests for your procs

- You put your files into git

- Then, in a transaction, you drop your old schema and deploy the new one
So you think the accused killers family would be much happier if they found out he didn’t kill either of them, just had sex with the dying girl and left her to die?
The existing system also isn't meritocratic.

I attended TJ. I remember the test prep and the BS extracurriculars to pad resumes. I am not convinced that a student who has a 3.5 and has taken accelerated courses is unprepared to attend.

Extracurriculars at TJ (at least many years ago) were also tremendously diverse. Sure, somebody who has only taken Algebra 1 in 8th grade is less likely to end up with the top scores in the math olympiads out of the whole school (though who knows, loads of students didn't attend a school that offered algebra 1 in 7th grade so maybe they were brilliant and didn't have the option), but when I attended I did stuff like play bridge, watch rock concert footage, or rehearse a play during 8th period. This does not feel like a meaningful concern.

Are you a TJ grad?
This is easy in the US, check out Care Oncology.
Why not create a service that downloads a DNS cache of the - however many DNS names you can cache in a 10 or 100mb file and thereby allow a raspberry pi to reply to most dns queries?
Ask HN: Why are there still no *really* good AR apps or games?
> it also trims 0.1 seconds from both ends of each sentence's audio so the key press noise is removed

If you wanted to, you could probably use something to wait for sound level to drop, and then cut until the silence ended. Although a fixed cut probably works fine, too.
Ah, I misread your original post. Sorry!
Evolution happens through reproduction, which tends to happen earlier in life. So if some gene confers an advantage in early life but a disadvantage later on, it's likely the disadvantage won't stop it from spreading.

If it's not widespread, it's either not an advantage that "matters" or maybe it possibly has some negative interaction with other traits that matter for reproduction.
Gwern did some analysis and determined that the ROI for Metformin vs the cost is positive for 45+ and older.

https://www.gwern.net/Longevity#metformin
Distilling many pages is the first step in writing your own response (over many pages). It’s essential and a very healthy impulse.
Some oils like rapeseed (canola) aren't that good for you either.
Multiple sources say it absorbs best, it's also extremely cheap which means you can use it in baths, and topically in general.

Other forms bound to various amino acids like magnesium glycinate are good too, but you can also supplement those amino acids separately.

Magnesium chloride is water soluble so it's great to dissolve in your drinking water and drink throughout the day.
I believe that’s the case, yes.
The facts are more complex than that.

Unlike the stable photon, the W bosons have a negligible lifetime.

So in fact those processes listed by you that result in 2 particles are 4-particle processes.

Two particles collide, either a quark and an anti-quark giving other 2 particles, a lepton + an anti-lepton (in your exemples positron + electron neutrino or muon + muon antineutrino) or a lepton collides with an anti-lepton giving a quark and an anti-quark (in your exemple up quark + anti-down quark).

So there are always 4 particles, either quark, anti-quark, lepton and anti-lepton, or there may be both at input and at output a lepton and an anti-lepton, which includes the case of scattering through weak interactions, or there maybe both at input and at output a quark and an anti-quark, which includes the case when a meson decays into another meson through a weak interaction.

All the interactions involving W bosons are 4-particle interactions, where the W boson is an intermediate particle that exists only during a negligible time.

The 4 particles may be all at the input, all at the output, 3 at the input and 1 at the output, 1 at the input and 3 at the output or the most frequent case, 2 at the input and 2 at the output.

Like all the interactions between elementary particles all these cases are equivalent and all the variants are interchangeable by moving a particle from the input to its anti-particle at the output or vice-versa.

In most cases you need to pay attention only to the 4 particles participating in the weak interaction and not to the intermediate W boson.

The existence of the W boson matters only when you need to compute various things because this intermediate particle transforms diagram nodes with 4 edges that cannot be computed into diagram nodes with 3 edges that can be computed with the methods of quantum electrodynamics.
I don't remember the article but I remember reading about a building management game where the reviewer believed the entire game was based around the elevator management code and that writing that code was fun for the programmer but the game itself was not fun for the player.

It looks like this highlights the "fun for the programmer" part.
If I had to guess, it could be Russia. The majority don't trust their home brewed vaccine. I'd say according to the data I've seen they might be right. Maybe we should gift them some Pfizer vaccines!
> I do accept that John Smith has an unfair advantage over Rajesh Kumar when applying for a software job at a FAANG.

Don’t know about UK, but in the US the advantage quite decisively goes the other way: people of Indian descent are significantly over represented in FAANG relative to their share of population, and people of Anglo descent are significantly underrepresented.
The dose makes the poison. Everything in excess is detrimental.
Sorry, would "functionally inferior" be a more suitable name for it? I've come to expect robust and fully-featured WMs from years of using Windows and Linux, it's a bit funny to me that Apple has just given up in this respect.
Or trigger on key up? Though I suppose maybe there's a slight sound still when the cap hits it's maximum travel if it releases the switch before that?
http://www.micktagger.app

I have a lot of Spotify playlists and I wanted an Alfred like tool to quickly add songs to my Spotify playlists, mostly using my keyboard. There was none out there that I was happy with, so I built it myself.

Fast forward to today, I've added a few more features I wanted for myself - auto removal of songs I skip often, auto like of songs I listen 100% and a smart playlist feature that gathers new songs from playlists I select into one separate playlist, every Monday.
https://www.npmjs.com/package/tavuelo - I've created own Vue.js table plugin because I was so annoyed with customizing another table from UI library for the 100th time to achieve similar result so I've created a dedicated solution that will cover most common problems/requirements I need to develop at work.

https://github.com/writteli/writteli - I've created static site generator because I've wanted something that suits my needs for 100% and I won't need to "fight" with the 3rd party solutions to achieve what I want. Also I've wanted to learn something during the process. I'm using it on daily basis to maintain my website (https://lukaszkups.net) and also now I'm working on a desktop app that will be compatible with it.

https://github.com/mrmnmly/scaffolder - I was sick of creating boilerplate code over and over again when I was doing my baby steps with Meteor.js so I've created a stupid simple bash script that will generate it for me.
I believe that the curse of dimensionility doesn't apply here as we are optimizing the "universal apppriximator" of the "surface" of the possible real world function.
Not really special. Try simulating this:

Start with bunch of objects at coordinates 0,0,0. Give them random velocities from 0 to c. Then just let them move according to Newtons law.

Now focus on single random object and narrow down your field of view so you won't see the edge. Look at other objects. They will seem to be moving away directly from the point you focused on with velocities proportional to distance from it.

I made such simulation and made calculations to ensure that the velocities of other points face directly away from the point I'm observing. And they really do.

Even in completely flat Newtonian universe there could have been a sort of Big Bang with epicenter and it could be as simple as "give matter random speeds" and we living on a one speck of matter would have no way to figure out that there is a center or where is it.

When I asked about this on physics stack exchane I got a shurg that, yeah cosomology is basically that but with Einstein not Newton.

All that talk about spacetime inflating is just a result of matter 'dragging' the spacetime along as it moves.

The faster than light galaxies far away are not a problem because the speed of their movement that we measure is sum of their kinetic movement (which could be almost at light speed) and expansion of the space time between us and them as the spacetime is 'dragged' by them with GR. But you can equally well interpret the math and data as galaxies roughly at rest and all the speed coming from spacetime expansion and for I have no idea what reasons people actually prefer to do that.
> 40% of them don't reproduce at all

Plants can reproduce asexually and ferns do it all the time.
Not really, though I can provide any valid LaTeX input and get the appropriate result back. To be honest the setup is not ideal, as the input is first converted to a PDF file (that has to be saved in a temporary directory, along with other residual files, as "pdflatex" doesn't support stdout/stdin, for some reason), and only then to an image. Still though, it's much snappier than relying on online "latex to image" converters that basically do the same thing on a server somewhere.
The first seat on New Shepard sells for $28M
Anyone got an archive link? I can't read this without making a Facebook account and signing in
Staff continuing on as freenode staff is really dodgy, especially now that #python was just manually hijacked in the last 24 hours and Python foundation staff klined. Not a good look to be in such company.
That immediately fires back at the poorest who can only afford to rent - good chunk of the tax will be passed onto them.
Good, freenode is toxic
Does “possible” in your statement refer to the inherent constraints of the architecture as specified by the researcher, or something else?
The time series in your link end in 2019, when the trend of falling violence has ended. There has been a huge, unprecedented spike in violence in 2020, and this new normal has wiped decade or two of previous gains.
> you probably aren’t the right guy to drive the success of a startup.

Since when did giving honest opinions about speed and practicality merit personal insults?
I've worked at plenty of businesses with annual revenue in the tens of millions using "non-scaled" solutions without any issue.

If we rephrase question to the material reality of "What will we do when we're pulling in $20,000,000 a month?" then you can see how silly it is.

I dunno, just buy a company then and use their stuff? It's literally not a problem that a pre/early-revenue company should or realistically can solve. It's part of "founders delusion" - the same kind that make them get a huge office that's mostly empty or all that unused computer hardware sitting in the closet. It's just gambling.

It'd be like saying "we have $500,000 in the bank at this new restaurant and need to be ready service 5,000 national locations with our staff of 5."

I mean no, by the time that's no longer just a mental exercise (as in you have, say 4,700 locations) you'll be a different kind of institution better able to solve the problem. Literally just forget about it. It's so profoundly irrelevant...

Solve the problems that are actually real, you've got enough of them, I promise.