skysight-inc/HackerNews huggingface dataset:
Given the studies showing higher rates of chronic infections in Alzheimer's patients (like herpes viruses and periodontal disease), why aren't there more trials like this:

https://clinicaltrials.gov/ct2/show/NCT03282916

>Anti-viral therapy in Alzheimer's disease will investigate the efficacy of treating patients with mild Alzheimer's disease with the U.S.A marketed generic anti-viral drug Valtrex (valacyclovir, 500mg oral tablet). Valacyclovir, titrated to 4 grams per day, repurposed to treat Alzheimer's disease, will be compared to matching placebo in the treatment of 130 mild AD patients (65 valacyclovir, 65 placebo) who test positive for herpes simplex virus-1 (HSV1) or herpes simplex virus-2 (HSV2). The study will be a randomized, double-blind, 18-month Phase II proof of concept trial.

I understand beta-amyloid is still the most likely cause of the disease, but given how lackluster the results of targeting beta-amyloid have been, why can't alternative hypotheses be investigated more fully?
How is google a global monopoly, there are other search engines out there, other mobile operating systems, other cloud providers, etc.

EDIT: not even trying to bicker, there are multiple comments calling Google a monopoly, but I have no idea what market they dominate, or perhaps I’m misunderstanding what I monopoly is.
However, even with an email address, what are the chances you eventually try and email someone who has gmail. If you get put on the spam list, youre as good as not existing. In concept thats not that different than having an internal account shut down. You still dont exist to google, or any of their patrons.
I'm not a fan of web frameworks such as React and CSS in JS, but to be fair, you should not stare blindly on first-time-load times! Imagine if you would include download and install time when you measured native app performance... You should also take into account repeat use performance! While most "users" will just load the app once and leave, those who actually use the app will spend hours clicking around and doing stuff, and that's where aka "single page app" have an advantage over full reloads. Measure things like click latency and re-render times!
Never that simple at a macro level. Business will claim more knowledge of the “market” and are probably right if they have got feedback from customers. “We need to build X as part of our strategy”

Sure you can choose to use nodejs instead of ruby or embed video instead of streaming it yourself or find a better confit system than admin pages but the entire product ideas are probably decided by the business well in advance of when the developer gets whiff of it.

Imagine you are about to purchase a car and the car dealer weirdly tries to convince you to take up cycling via “what’s the problem”. You’d probably walk to the next dealer as you’ve made up your mind you want a car.
Reminds me of this line by tom_mellior[0]:

> I wish people stopped approaching language design from the point of view that the people who have been working on garbage collection for the last 60 years are all idiots who don't see how simple it all is.

[0]: https://news.ycombinator.com/item?id=26765369
Moving goalposts is not a concern either.
CSS and Javascript are concerns, becaus HTML is of content/structure, CSS is for styling and JS is for behaviour. Of course somewhere along the road devs thought that HTML and CSS are to primitive to spend any time learning them properly, because of that they later found them to bee too complex and we ended up in the mess we are right now, when we try to hide the lack of understanding under multiple wraps of abstraction.
I'd back up and say it might be even more simple from a cybersec perspective, holding off the military drone capabilities and related hardening.

Embedded consumer electronics/IoT generally have awful security configs and an internet connection. Consumer-grade, and I bet a fair bit of the more high powered drones, are vulnerable to this same risk.

I'd love an educated opinion on this, but to the extent I've thought about this as well - many of these drones must be vuln to some form of remote code exploitation and shutdowns, if you can get a targeted signal to hit their admin "beacon" or w/e.

As consumer drones do show up in warfare a fair bit, this feels like a possible counter-drone route to explore.
I remember the hubbub a year (or longer? another covid timewarp) ago when this first came out. It looks like now the dev of V is just pulling under 1K a month so it's not like he's making bank so if they're still just grifting it's not really working.
> I never told any adults what I was doing until I was nearly an adult myself, out of fear they'd ruin my hobby like they did everything else.

I dropped out of college and was ~4 years into a successful career before it clicked with parents and other "adults" of what I had done and what I had "thrown away".

Having been through 3 serious tech jobs and dozens of interviews only one company rejected me due to my lack of a degree - Capitol One.

All said however I do think about going back to complete my degree at some point as I expect as my career progresses to upper upper management it might get in the way.
Maryland Among First in U.S. to Limit How Police Use Genealogy Websites
A flat tax removes the simliest fairest part of the tax code and leaves all the bullshit and loopholes behind. Don't make the mistake of thinking you're (and my) experience of the tax code is anything like the actual code. We only see 0.001%. It's easy to consider only the things we see after all.
More on this if you have a WSJ subscription:

https://www.wsj.com/articles/irs-is-investigating-release-of...
of course they're political, how else do you get to change policies? chaining yourself to trees doesn't do much nowadays.
So google would be a public utility... but not my ISP?
You see this in the evidence of the Arizona lawsuit against Google. They have internal emails from Googlers who dared to complain about the confusing settings for location tracking (How many still work there?). Nothing from the managers who cooked up the scheme.
Check what Aliexpress has to offer for 1/10th of the price... Even with games, it seems very expensive...
Great project! I didn't know I even like the daft punk, but it sounds incredible. Some options about skipping the song on the radio would be perfect. Also, I think that the "heart" icon doesn't work.
No grifting going on. We have a vibrant awesome community that feels very Ruby-like in many ways. Good people.
Added one more point on API. Also, you'll probably end up using one more library called classname for better classname management.

https://www.npmjs.com/package/classnames

In the end, I generally prefer to use tailwind + emotion. My goals usually is to save time and make system more consistent rather than perf gains, which isn't that much on new systems.
Major internet outage ‘shows infrastructure needs urgent fixing’
https://cbeci.org/cbeci/comparisons/

BTC uses more annual energy than the Netherlands. What did it accomplish when compared to the economic output of the Netherlands?
This doesn't have any real goal. The point is to start it, and once it will fall, blame it on Democrats.

If they were serious about it, they would start with declaring ISPs as utilities.

Also by all means I think that Google, Amazon and others should have be split into smaller companies.
> Walking through my school library many years ago, I walked past a copy of Plato’s Republic, walked back, picked it up, and started reading.

If you've never read Plato before, I'd suggest not to start with the Republic — it is diving into the deep end of Plato. I'm saying this as someone who has recently completed Republic[1], and thoroughly enjoyed it (and fumed at it in some places).

Instead, get familiar with some of the earlier, and famous, Socratic dialogues: Euthyphro, Apology (this is referring to a "formal defense", i.e. apologia; not regret), Crito, et al — they're shorter, give you a great flavour of Socrates, and will prepare you for the Republic. An excellent English translation here is the Five Dialogues[2], a fine selection by Hackett Publishing. I'm happy that I started with this.

[1] There are many English translations; I'll strongly recommend the "Reeve Edition". This translation recasts the entire dialogue as direct speech, this makes it easy to keep track of the speakers. Ensure it is this Reeve-only edition (because Reeve also revised an earlier translation by Grube): https://www.hackettpublishing.com/republic

[2] https://www.hackettpublishing.com/five-dialogues
I certainly appreciate the apology, but please don’t spend another second worried about it. Wrong account but fair point. And even if not, folks make mistakes.
Food labelling and advertising law (Chile)
Your example was a $50k tractor that you couldn't work on or a $100k tractor you could fix yourself. To me that means that by buying the $100k tractor, you're giving them an extra $50k to make up for the money they would otherwise make off repairs. It's whether it's reasonable for a company to sell you a product and then expect any loss in profits to be made up at a later date with maintenance. Almost like a loss leader.

You continue to argue that because this is what the market has come up with, there is no better way to do it. You can absolutely, as suggested in the article, make it illegal to make it either illegal to do your own repairs or impossible without purchasing certain software or licenses. But because the market hasn't decided that and it's a form of regulation, then it must not be a good solution. I'm sure there are plenty of unintended consequences to legislation like this, but the consequence of no regulation is a situation where you can't repair your own equipment and the dealership can charge however much they want for the repairs, as you have no recourse.
The authors conflated right here...

"The results are stark. According to Forbes, those 25 people saw their worth rise a collective $401 billion from 2014 to 2018. They paid a total of $13.6 billion in federal income taxes in those five years, the IRS data shows. That’s a staggering sum, but it amounts to a true tax rate of only 3.4%."

Income taxes paid divided by increase in net worth, how is this NOT conflating?

No one's definition of 'true tax rate' is calculated this way.
So it’s okay for banks to choose who they’ll let bank with them?

In any case, I disagree. Some things are basic necessities.
Rarely, just like the rest of Western Europe. But most of us build with stone for the very reason of the relatively calmer climate. Because there won't be any storms knocking them down, so it's worth the investment.
Nutri-Score
Name even one way in which Google resembles a public utility.

When I build a house, do I have to pay $25k to get my Google pipes hooked up? Seriously where are the parallels?
Oh yes so it’s 6.25 x the amount of users indeed. So that’s 25 a month for the family. It’s just a bit too much. I pays this per year now roughly with unlimited mailboxen. Sure, I’d pay more for ProtonMail, but not this much.
There already exist paid search services which you can compare Google to. I use infinitysearch and it costs US $5 per month.

It's true that their coverage isn't as good as google, but around $1 per week feels very cheap. And the decreased coverage is at least partly compensated by being treated like a customer instead of a product.
We literally are talking knives on RC planes; see the comment I originally replied to. You are moving the goal posts.

A quad will tumble with the motors off, the whole thing is a significant lift force. It was a big problem in early controller software where throttle dead zone would turn off the props. A problem I personally experienced. Maintaining any semblance of stability requires active adjustment.

And no, Ardupilot will not get anything going at high speed to within a few feet in 3d space.
Cool, I would love to see some numbers! I know that some official images aren't updated for literally months (e.g. `centos`, even before the CentOS/RHEL decoupling), but others are more frequent.
I do too. There is something about building your own idea that’s magic. Even partially magic is given the “we need an x” but deciding on the technical and visual design. Team work is probably more effective here: graphic designer. UX, product managers etc. at producing the polished results we expect in the 2020s but man … why are we drawn to side projects? The urge to build from the ground up is strong.
I wish they would do that as well, but that certainly doesn't invalidate these concerns
The `count()` "hack" is so common that it barely qualifies as a hack anymore. It's just common practice and immediately understandable when you read code.
"Principal", not "principle". I complain about this mistake when others make it.
And the imap part? The opensourced Mail client on the iphone?

iCloud has an MTA?
Apache Calcite 1.27.0 Released
> ...their monopoly, which is why Google should be broken up.

Not denying their monopoly position, but how could Google meaningfully be broken up? It's really just a single business (advertising) with a gaggle of loss leaders adding up to less than 20% of revenue. Even pushing advertising down to 80% took a huge amount of effort.

It's not like Standard Oil which was a vertically integrated trust of several points in the value chain, or the bell system which could be broken up geographically (and manufacturing spun out). Or FB which could divest business units like Instagram and WhatsApp.
Well sure, the title was just an example. It usually is more like this:

"Encrypt project's sensitive fields (#1234)"

With the number being a PR or an issue # (which does contain a link to the PR).

I do care about history in branches though. And many others do. I agree that it varies from team to team.
I'm afraid I don't get it either. To me, the big disadvantage of css-in-js is that the browser doesn't display it neatly.

If I write plain CSS, it's easy to make changes right in the browser and have it react instantly. Or I can make them in the .css file, and webpack (or whatever it is) will automatically redisplay them without having to restart the app.

Perhaps if I had much larger projects I'd see more headaches that drives people to css-in-js. But I manage fairly large things and don't have too much grief with plain css.
Of course they aren't, which is why they're perfectly happy to continue refinancing. They make money on the interest, not the principle. And each refinance increases the bank's total collected interest. As long as they eventually get the principle back, a bank is perfectly happy with this arrangement.
Bill Gates started selling off his microsoft stake in the late 90s. It took him more than two decades to get from 49% ownership down to the 1.9% he has today. It's hard for figure heads to divest without crashing the stock because it carries substantial signal risk.

The stock market is only liquid at smaller scales, bigger transactions will have dramatic effects on the price.
Yes.
Banks close accounts all the time of clients they no longer want to risk business with.
why have a different interface than the expandable [more] used for dead comments?

seems intuitive to piggyback on the same fading ui hint as comments, having a bright "more" indicating standing of hidden comments...
This is interesting but it is not in the least bit philosophically satisfying as an attempt to answer the question of whether beings are "automatons" or "conscious".

To begin with, it is not at all clear that those form a valid dichotomy, as is evidenced by the debate over free will. If we have no free will, we too are automatons, but we still can assert that we are conscious. Can we be both? I'm pretty sure the jury is out on all of this.

Is a bed-ridden, non-communicative human patient non-conscious because they follow strict patterns? We frankly don't know, but it is widely regarded as unsafe to assume they are not. Are there philosophical zombies out there? It's unknown. Does the universe exist beyond our own perception? Again, sadly, no one can be completely sure.

So, your cat's behaviour might be on rails, but we know nothing of its true internal experience, let alone whether that experience meets any arbitrary bar we wish to claim is special or privileged, especially on the mere basis of it appearing to be similar to our own.

(apologies for making multiple edits here)
How is Google a monopoly? Serious question.
in that case you don't send them a randomly generated string called a password but a randomly generated string called a token, right?
"Sorry Mr. Jones, we've decided your, ahem alternative lifestyle and beliefs are fundamentally incompatible with the views of our company. Your electrical service will be discontinued in three to five business days."
Autocomplete is automatic in Intellij as far as I can see. I don't recall doing any kind of custom configuration to have it working. Autocomplete works on resource names, variable names, properties, etc.
Not a great reading experience to have to scroll through nearly endless fawning of "ooh look at how we are such responsible journalists" to get to the actual story.
These issues should / could all be addressed - if you're in Discord already, which it sounds like you probably are, feel free to talk about each point. The C2V source IS in fact, already available to many folks (v devs specifically, of which there are many).
The neat way to re-run a layer daily is to use a build arg:

FROM debian

ARG APT_UPDATE_DATE
RUN apt-get update && apt-get upgrade -y

Then `docker build --build-arg APT_UPDATE_DATE=$(date +%Y%m%d)` will always re-run the `apt-get update` for the first build each day. You probably also want `--pull`.
It's a fine tool, but all the other comments as peers of mine highlight the same kinds of issues I mentioned and got completed downvoted for. So clearly there is something to it. Nobody is hating on Terraform, just trying to avoid choosing a tool that makes their job more difficult than alternatives.
yes...? if you overdraw your account and/or bounce checks over and over, it's not unreasonable for the bank to close that account eventually.
Scotland has a separate police force.
If you want to talk about specific political parties on HN you have to use coded phrases or you will get flagged and downvoted. The current ones are "college educated" (democratic) or "average American" or "not city dwelling" (republicans)
> in the US there's no such thing as a noose that's unrelated to race

People do frequently hang themselves, and there have been some stories of people tying nooses as jokes about suicide or overwork that were misinterpreted as racist threats.

I'm not sure if a joke about suicide is much better than a joke about lynching, and not being aware of the possible racist interpretation is tremendously ignorant at best, but it's clearly not as horrendous as an actual, real death threat.

We should strive to leave at least a little room for nuance and context, and making broad statements like "in the US there's no such thing as a noose that's unrelated to race" leaves none.
How a Raspberry Pi made it difficult for one astronaut to get to sleep on ISS
What are your thoughts on darkhttpd?

https://unix4lyfe.org/darkhttpd/
Segmentation Fault: Core Dumped Error – Need Answers
Consider the Lobster - David Foster Wallace (2004)

http://www.columbia.edu/~col8/lobsterarticle.pdf
I don't know where I stand on the public utility argument, but to make the strongest possible case for this analogy: most peoples' online lives (including their financials) are tied to a singular email address. That email address forms the ground truth for their identity, including being able to access services that they've lost their credentials for.

Google's ability to unilaterally revoke access to the account that ties you to your banking accounts, your state's online service portals, &c. gives them the kind of power that we'd normally only see in regional monopolies like water utilities.
Unfortunately that skepticism is warranted today. American politics were always somewhat broken in the past, but the blatant partisanship today makes any kind of progress almost impossible.
The DeFi Bond Market
Axolotl Finance, Claim 1$ ($AXO) each 15 minutes
Without going into too much detail, my mother¹ had a way of interfering in my attempts at projects both by trying to tie it into "getting a credentialed person on board"² for Proper Supervision and piling on… other abuse, often after I was a significant ways in.

Fifteen years after escaping, I still haven't published anything real, and I can see the pattern. I saw the pattern ten years ago, even, but deep conditioning is really hard to break. Only being able to finish things for other people is kind of a disaster, especially when you wind up in the “need experience to gain experience” trap.

¹ Who, again without too much detail, was Asian.
² Which never happened. She never put any actual energy into it, I had no framework for approaching it as a child, and I'm not sure the surrounding environment contained people who were willing to do that sort of thing anyway.
Hm. Here's Ohio's definition of a public utility.[1] It might be argued that Google is a telephone company or a messenger company, but that's a stretch.

Regulating Google as a common carrier would make more sense. Common carriers (which, by the way, UPS and FedEx are not, but Union Pacific is) are required to accept and deliver cargoes for anybody who ship according to their posted rates and terms.

[1] https://codes.ohio.gov/ohio-revised-code/section-4905.03
I agree the React implementation is very complex, but in a way that's by design: we add features to React when it allows us to move complexity out of our product code and into a framework.

Like, yes, implementing batching in React was complicated, but in exchange the developer doesn't have to think about it anymore. It just works!
Even just divesting YouTube would be a start.
I think the market is more to treat the stake in a company as a liquid asset. Such that you can transfer stake to someone else for an agreed value.

But, it is not the value that is liquid, necessarily. It is just the stake. In theory, there is intrinsic value to this. In practice? Much more complicated.
He lives in Sweden where the cost of living is quite a bit lower than most of the US and also has people contributing to him on GitHub. A quick Google search suggests it's quite possible to live on $1k a month in Sweden for one person but I admit I have no personal experience in that point.

Edit: I was wrong about the location but that does not change my opinion.
I may be misunderstanding this. Does this mean "You [a business] shouldn't have to do business with people you don't want to"? If so, why should rights of people extend to businesses? People already have the freedom of association of employment that seems to cover this. ie: if someone doesn't want to associate with someone else as an employee of a business, they can simply not work at that business.
Engels famously compared Marx to Darwin in his eulogy. But Marx's problem was that he tried to predict too much into the future and was shown to be wrong in almost all of it - most notably the only communist revolutions happening only in agrarian states.

Darwin (and Wallace) only provided a model of natural selection that predicts pretty much nothing about the outcome, only about the process that will be involved and the general shape of the outcome.

So Darwin is now (rightly) seen as a great scientist and Marx (rightly) isn't seen as a great historian. But the general shape of the Marxian model is still useful to many people. Even if it's not very predictive in any useful way.
Grades are an easy way to communicate your value. They stop mattering when you have alternative way to show your value (e.g. work experience).

Finding non traditional ways to demonstrate your value can be hard and is a skill that isn't really tought. If you're going to not care about grades you better be sure you know some alternative way to show your potential value.