skysight-inc/HackerNews huggingface dataset:
I'm not sure whether on the balance gain of function research is a good idea or not. The point of my comment was just that discussing the impact is highly relevant, and isn't "putting the cart before the horse". But I guess I should expand on it.

Regarding whether gain of function research is a good idea: Creating synthetic variants (to see if there is gain or loss in function) is very helpful in that it allows well-controlled experiments, which is necessary to establish causation. As I said elsewhere, I don't think the risk is appreciably different whether the lab's collection of dangerous viruses is all-natural or not. That is, if we ban gain of function research we should probably stop studying the unmodified variants also. There have been near-misses with accidental releases of SARS-CoV-1 and Guanarito [0]; no gain of function required. And the 1977 release of H1N1 came from vaccine development.

Regarding describing the net impact of gain of function research as one pandemic, zero help:

I don't know what would be different if gain of function research had been banned. The underlying methods have been used since at least 1999 on, among other things, MERS and SARS-2003 [0], so they have contributed to the general knowledge base that permitted extremely rapid development of the COVID-19 vaccine. This was a significant help, not zero help. On a technical and scientific level we were very well prepared for COVID-19. Its biology was well-understood almost immediately. Our failures were on the social and organizational levels.

Was gain of function research genuinely necessary to achieve that level of preparedness? To answer that one of us would have to sift through the body of work on COVID-19 vaccine development and trialed treatments to see if the people involved used information from mutagenesis or infectious clone technology experiments (the work that is being referred to as "gain of function"). I haven't done that, so I can't give a definitive reply on that point.

There is also the matter of side effects from a ban. Creating synthetic variants within the scope of naturally occurring traits seems acceptable given the benefits. But there's no guarantee what a given edit will do in advance. If you ban all genetic engineering that could lead to gain of function then that will severely hamper research, including development of vaccines and antivirals.

So overall I guess I favor a restriction on deliberately increasing pathogenicity, virulence, and transmissibility beyond levels that occur in similar natural viruses, but allowing the possibility that this could still happen unintentionally. I also think synthetic variants should be destroyed as soon as their purpose is complete, and facilities where these viruses are studied should have a test/trace/isolate plan in continuous operation.

Edit: We also have to keep in mind that COVID-19 wasn't necessarily leaked from a lab, and even it was, it may be a naturally occurring variant. Which would make much of this speculation pointless.

[0] https://yurideigin.medium.com/lab-made-cov2-genealogy-throug...
Yes, it allows you to buy more for the same amount of money, increasingly as time goes on. This is why it results in economic slowdowns, because people are more hesitant to spend money when it may be worth more later.

In fact we see this in a small scale in the tech sector all the time: products get more powerful or cheaper or both, meaning people who might want to upgrade often agonize over waiting to spend their money to a point where it will obtain more per unit of value.

Or with Crypto, consider the HODL mentality. BTC would have made a lot more progress towards use as a medium of exchange if an enormous number of people weren't simply buying it on the hope of future value, or speculate by continuously selling the peak and buying the dip. There's even the cautionary tales in the crypto community against actually using any if it to cash out for purchases, such as the person who paid for a Pizza with enough bitcoin to be worth over $100,000,000 today. The message is "Never use it, always HODL" Of course there's always the anecdotal person here an HN who will chime in with, That's not true, I just bought X with it!". Which is fine, but an extreme outlier.

It will never deliver on it's goals when that, and investment speculation, are the two dominant use cases. Bitcoin is trapped in a cul-de-sac right now, and absent some unexpected event, mainstream everyday use of crypto by average people-- if that comes to pass-- will bypass BTC by as it circles around that cul-de-sac.
Among Us'-shaped McNugget sells for nearly $100k
Blood, Stones and Holy Bones
Best homemade mask for anti aging
Easy to make at home
http://healthwithbeauty.xyz/2021/06/06/cucumber-and-egg-whit...

Among Us'-shaped McNugget sells for nearly $100,000
https://www.interestingnews.club/2021/06/among-us-shaped-mcn...

Most colorful animals in the world...
https://www.interestingnews.club/2021/06/most-colorful-anima...
No kidding a CPA in my hometown went to prison for fraud named…

Cheatham
While we are at it, let's also change the road sign "left lane must turn left", because a lane is not capable of turning left.
Pronounced “Made off”
No, you were correct, arithmetic mean of returns is not standard in finance. If it was, financial crashes would be much worse. They do arithmetic means of "log returns" because 1/n sum(log(r)) = log(product(r)^(1/n)). That is, in log world, the arithmetic mean is the geometric mean.
Bitcoin may ultimately become a store of value, but highly volatile asset classes are not what people look for in that.
What you're ignoring is that employers have been using "has a degree" as a filter for decades now.

Any type of position, including the lauded "learn to code" ones, starts with "do you have some type of degree?". This is the rule, and while exceptions exist, they're not common or reliable. It is still generally looked down on to only have a high school education.
"Vanishing" seems a misleading headline. This isn't a case where Argentinean boats are mysteriously lost at sea and their crews are sadly never heard from again. This is illegal fishing from other countries.
Giving American fast food restaurants two paths:

1. automate

2. become a charity
> but errors of commission are the only ones picked up by most accounting systems

Except for actual accountants, for whom I can attest certainly do hunt down omissions. Especially when it's not your money you're spending.
important information: the genetic code is redundant, there are more than one codons corresponding to an amino acid.
keep in mind a codon is three "letters"

https://en.wikipedia.org/wiki/File:GeneticCode21-version-2.s... [start at centre find first letter move to ring 2 find second move to ring 3 find third, find amino acid coded] notice that there is more than one codon corresponding to most amino acids, and some codons are control words.

also you needto look at 2 things, regarding Fig1b

there is comparison between two different coronavirus
CoV-ZXC21 [upper sequence] vs. the 2019-nCoV [lowersequence]

the regions are different 651-661 in the first case, and the region 676-690 in the second case[2019CoV] these are different coronavirus so this is expected however they both correspond to a domain of the Spike protien [S]

what is being demonstrated is that there is a region in the 2019-CoV spike protien that is "novel" ; 2019-CoV predecessors dont have this sequence. this sequence is a cleavage recognition site. this in basic terms "arms" the coronavirus to fuse with a cell when cloven at the sequence by "furin"

this means the 2019-CoV is more likely to initiate fusion functions inside of a host rather than elsewhere, thus more viral copies would be capable of actually causing infection before being disrupted by the surroundings.

the basis of many gain of function research gone wrong concerns is the presence of this cleavage recognition sequence. The Double codon insertion is being used to bolster the idea that this is engineered, the major fault in the premise is that there is no natural way for such insertion to occur.

look at TABLE1 below Fig1 and you will see that other coronavirus as well as conspecific virus have such a cleavage site thus a natural origin for the sequence is not impossible.

i have mentioned recombination, and transversion as completely plausible natural phenomenon that have been recognized for some time, thus the statement that there is no natural way for this [insertion] to occur is fallacious.
Hey everyone, creator here. I had planned on launching here at some point in the future, but someone beat me to it.

The motivation behind creating Mastershot was because when searching for a simple free video editor to use, they always hit me with either a low-res export or heavily watermarked or an exorbitant subscription fee. Mastershot is able to be free because it uses an WASM port of Ffmpeg.

Currently I only support chrome because of a weird bug in FF that is causing the ffmpeg port to break. I’m working on an approach to make Mastershot work cross-browser the same way that the video trimmer and audio extractor tools work.
I don't think laziness is their premise, but rather the result - I think GP is referring to:

> Therefore, the question should be "what if the (minimum) wage/pay provided (at least the same) liveable value"? [Or, rather, that is the problem.]

Unemployment was boosted during the pandemic to where a large percentage of low-skilled workers had exactly that cost/benefit to consider: Unemployment paid more than the job they lost, and now employers are looking to get them back without a raise.
Oooof, that sounds painful but also a pretty atypical experience for people not living alone. My girlfriend has a job where she's on the phone a lot, but in the other room with the door shut that isn't really a problem at all. I can barely hear it, and if I have my headphones on I can't hear it at all
I was CSIRO DIT in times gone past, 1988 timeframe. It was an amazing place to be. We were doing OSI work. Perhaps it's better that didn't go the distance :-)

SEL is a modern miracle. The decision by the government to de-fund the work is a tragedy.
India is actually ahead of the UK and immediately behind Germany.
Part 1: Building a Java Microservices E-Commerce App
One key factor that is crucial to understanding the current systems: over a number of decades, the American worker's general experience and compensation has been ratcheted down, one bit at a time. Each year brought less pay (adjusted for economic growth), less autonomy. More efficiencies, more consultants. While pay stagnated.

Quarantine has given people a chance to decide if that's what they want to do, at the previous wages.
It was true (well, in the same ballpark, don’t remember exact numbers) for the website I was in a position to see it for. It may be different for others, but like 98% of the malicious traffic comes from 3 or 4 countries.
This is top priority. In theory it should work, but there are few bugs still preventing it from working.
Cicero is an odd character to me - and I think I like him, because he is so very human. He is smart, witty, philosophical and could have had a long life, but vanity and a need to feel important caused him to make mistakes time and time again. He would even go against his own philosophies because of his need for status.

But, great thinker and tried his best despite failings. I kind of think that is a good role model - try to be better, know you are going to screw up, and keep on trying.

Also - he pokes young people in the eye in a book and I always thought it was funny in a philosophical way:

"And yet is there anyone so foolish, even though he is young, as to feel absolutely sure that he will be alive when evening comes? Nay, even youth, much more than old age, is subject to the accident of death; the young fall sick more easily, their sufferings are more intense, and they are cured with greater difficulty.

Therefore, few arrive at old age...

They say, also, that the old man has nothing even to hope for. Yet he is in better case than the young man, since what the latter merely hopes for, the former has already attained; the one wishes to live long, the other has lived long."

Source: https://newsletter.butwhatfor.com/p/takeaway-tuesday-on-old-...
I don't think collectivists in general think that individuals shouldn't be allowed to own guns, but that ownership can be well regulated, in the sense that gun owners should be required to show some level of knowledge and such before purchasing a firearm (that is, ownership can be licensed[0], as opposed to carrying).

Further, its not at all clear to me that carrying permits have anything to do with the constitutional amendment. The discussion at the time and the amendment itself refer to national defense, both from external and internal threats to the nation, not "bring a gun with me to the store" (concealed/open carry), which I think is what makes many people uncomfortable.

Many other countries have regulations of this form, that you have to purchase safety equipment and the government can audit you to ensure that you are safely storing your firearms. This gets people concerned about the government seizing your guns, but I don't think those concerns are realistic (assume the gov decides to do that one day, does having a national gun registry and your gun in a safe make things look any different than the police going door to door with a swat team and searching the house)? I don't think it does.

[0]: Eventually. this would take a generation or two
So, computers can now get viruses from living beings?
Well, they want punitive action against anyone doing the entirely legal, and correct thing by representing him, so they didn't want him having a fair day in court...

Again, laws don't matter... the truth doesn't matter, have a trial of public option, and even make it hard to have his side heard.

After all, they didn't want him to have a fair defense?

Canadians pay too much attention to US politics. We're not perfect, but for example "defund the police?

Look at a Toronto sized US city police, and social program budget. Now look at Toronto.

Surprise! Toronto's social programs almost rival the police budget. US city? Almost non-existent, and they get military surplus weaponry. No comparison. Not even remotely the same.

Yet Canucks run around, gibbering on about defund the police, when we've effectively always done that!

Perfect? No. But we should focus on our real issues, not transplant US issues here.

My point is, our courts are not US courts either.
A $50mil budget for a applied research project seems pretty low to me, especially when split up between multiple orgs.
This article is throwing shit at the wall hoping something sticks.

Despite the title, it doesn't offer a new definition of free speech. Instead it complains that other people want to redefine freedom of speech. Gore Vidal once complained that ABC cutting him off violated the first amendmend[1], Josh Hawley said the same about Simon & Schuster cancelling his contract. One of these things is "the continuation of a long-term strategy that American historian Joan Wallach Scott has termed the 'weaponizing of free speech' [...], or the deliberate misrepresentation of the very idea of free speech" and a "dangerous redefining of freedom of speech". No points for guessing.

The article argues that Kant's and Mill's arguments for freedom of speech don't apply anymore, Kant's because we live in a democracy, and Mill's because a lot of people are still wrong about stuff. After so much speech!

Hard to know where to even start here. It blatantly misrepresents Kant. Kant's argument in no way rests on his opposition to democracy. Kant simply argues that people must obey laws as long as they are in place, but should be free to argue against them. Needless to say, this applies both to democracies and autocracies. As for the argument against Mill, it's so stupid, I'm not going to bother.

[1]: https://www.vanityfair.com/news/2001/09/mcveigh200109
Fork() isn't even modern Unix. Pthreads is where it is at.
Yes, just linked that in another thread, then scrolled down a few more and can only concur it's the best of the offerings having a quick dig about. Nicely explains things.
Automation doest not bring deflation. It brings a higher standard of living where people have more money so they can buy more things. Prices still increase though-- inflation. The key is to have wage increases, and therefore quality of life, increase at a rate that at least slightly exceeds inflation so that people continuously have increasing amounts of money to improve quality of life.

This is why wage stagnation or when wages do not keep pace with inflation it's bad.
Ok, I'll play your game. Political enemies (in China, the USSR, other historic Eastern European states, Turkey.. maybe you'd prefer MLK as an example) are denied the right to life on the basis of their speech.

So if they fight for the right to not be sent to gulags (from which many did not return) on the basis of speech, you consider this an expression of "luxury"?

And do you think free speech might help fighting for their right to life? For example would BLM find fighting to end police killings of Black people easier, or harder, if they could be jailed for their advocacy?
And some other data points indicate its not that clear cut and that is my point. From the second link you mentioned:

"On the other hand will the total CO2 footprint from battery production increase in unprecedented pace and to
an enormous scale. If the value from GREET 2018 is used (73kg CO2e/kWh) the industry will go from 12
million tonnes CO2 equivalents to 106 million tonnes which is equal to almost two thirds of GHG emissions
from aviation in Europe . Even if this contributes to a decrease of direct fossil fuel emissions, through the 30
replacement of ICEVs to EVs, it will be a large source of CO2 emissions "
I hadn’t expected this to blow up as much as it had so I hadn’t polished up the homepage yet. My Twitter is @JacobBeckerman if you want to get it touch.
Lawyers sometimes have a duty of representation—-they can be appointed by a court, for example. People that are strictly unable to set aside their personal feelings in the name of professional responsibility are not fit to be admitted to the bar.
Which civil right is diminished by someone's offensive speech?
Industrial food production has had this problem nailed at scale though. I'm not even sure the technology isn't there - I think there's just not enough people working in the space to find the right design.
There are always some things that are expensive and some that are cheap. It is not a binary mode for many people to be in one or the other.
Kurzweil used to treat exponential curves as if they were "hockey-stick" shaped and there was a meaningful turning point in the shape of the curve itself. So it's arguing against that silliness, not claiming that exponential growth doesn't involve meaningful change.
Yup, I’ve been hearing that a fair bit. I’m slowly working through usability issues.
What was the point of all of the globalist nonsense that The United States has been up to for the last 40+ years?

It appears to have done nothing to stop China, which, just off of the top of my head:

1) Is by far the largest industrial polluter in the world

2) Seems hell bent on completely fishing all of the fish out of the ocean

3) Makes absurd territorial claims to places like Taiwan, Hong Kong, and the South China Sea, then acts indignant when these absurd territorial claims are questioned.

4) Is currently engaged in an active genocide

5) Perpetrated the deadliest industrial disaster so far (the wuhan lab leak)

6) Does all of this, in the rest of the world's face, and barely even bothers to lie about it. Then plays the victim if it is brought up.

I mean what the hell? What are we even doing? Is this seriously how the global order collapses? What does the world look like with a hegemonic China?

It is seriously the most depressing thing to me that the world appears to just be rolling over to allow a genocidal dictatorship to take over. Where does that leave humanity in 1000 years?
I'm not a fan of the CCP, but I don't believe several of your claims on the face of it.

What makes you say that the CCP are smarter than the WW2 Germans? And why don't you think that they have allies?
There’s no home field advantage in war
I meant having a controlled substance while also having a gun is illegal. I did not mean to suggest the gun was illegal. That was poor wording on my part.
He openly praised at least the main conspirator, Cassius, in his letters: http://attalus.org/translate/cassius.html#12.1

He loved the Roman Republic and it's senatorial grandeur, and hated Caesar for his illegal arrogation of power.
> If you want to join us why is this interview that you have with us less important than the two meetings you have around the time?

The other meetings mean I get paid? They provide me with a roof over my head?

If you were guaranteed to hire me by virtue of me attending the meeting, I’d probably peg it a little higher in the order of importance, but as it is it’s very likely a waste of my time.

So yes, I guess you could say I’m not committed enough, but that’s because 99% of the dates that I showed up on time for were secretly courting another guy and just ghosted me.
His CVE is good enough to get past any hiring manager for whom hosting the site would be interesting.

Rackspace:

- Principal Architect, OpenStack - Cloud Architect, Cloud Servers

- Chief Security Architect, Director
The final render is performed in the browser. I’m very much a fan of offloading computationally expensive take to the client so that I can provide this service for free.
The poster (Katie Herzog) has a podcast 'Blocked and Reported' which you may find interesting [0]. It's broadly what I would consider in the small-el liberal bent.

[0] https://barpodcast.fireside.fm/
Given the type of food restaurants make (oil and sugar rich - it's why restaurant food "tastes better") this would probably be one of the bigger improvements in middle class health.
I'm not here to glorify Stalin; he was a pretty bad guy.

But read about Occidental Petroleum, Armand Hammer, and how that guy sold the Ford tractors and built Soviet tractor plants for a nice sum in gold at the time when nobody wanted to touch commerce with USSR with a ten-foot pole. These plants later produced a lot of tanks for WWII.

USSR was not an industrial giant by 1940. Still, without buying Western tech, it would be even less of a giant.
This is in my backlog. Would you want to be able to specify the exact output resolution or would a few templates work fine?
Roblox CEO: Human reviewers are key to keeping the metaverse safe
It’s free to use, but it’s not open source.
Slow and steady inflation in the US has resulted in economic growth leading to some of the highest quality of life increases in the last century. A poor person today nonetheless has a higher quality if life than a poor person 100 years ago.
>Beekeepers use formic acid as a miticide against the tracheal mite (Acarapis woodi) and the Varroa destructor mite and Varroa jacobsoni mite.[29]

https://en.wikipedia.org/wiki/Formic_acid#Uses
> However, I believe most of these VCs still expect companies to be set-up as Delaware Corps. Anybody have any insight on that?

If you are taking money from US investors, being a Delaware C-Corp is what they are used to deal with and what they are comfortable with.

If you are selling internationally, a US setup might make lots of sense.
CSIRO does "basic research", but depending on what department you are in, project terms are limited and projects are focused on finding a way out of the building.

The projects I worked on were all on tight budgets and deadlines with the goal of finding a way to commercialize the research.

That being said, I'm not a researcher and my job was finding/developing a commercialization path for existing research.
If automation is cheaper, things should be automated. It's not, though.