skysight-inc/HackerNews huggingface dataset:
No, all prior attempts (that I'm aware of) have been to target amyloid plaques--amyloid hypothesis has been the big working hypothesis of Alzheimer's for decades. That they all failed has caused most in the field to abandon the hypothesis, and the fact that this is an amyloid blocker has most people expecting this to fail.

Indeed, the expert advisory committee at the FDA itself recommended against approving the drug, since the data on improving actual Alzheimer's progression is at best equivocal, especially given the past history of amyloid blockers. The FDA granted it essentially saying "there's nothing else there that works, and this does clearly clear amyloid plaques" (ignoring prior drugs that clearly cleared amyloid plaques yet still didn't work). And many people, including myself, are now preparing for the country to spend tens of billions on a drug which very probably doesn't work.

This does not paint the FDA in a good light.
I am not referencing a specific law. I am talking about intelectual property laws in general.

Surely people should be able to see how if you work at a company, and then release a product that copies what that other companies does, and you build something in such a way as it looks very similar to that other product, then there is a pretty big risk of running into intellectual property law or any number of legal issues.

This is a broad category of laws, where you could run into numerous issues. That should be pretty clear.
watchOS 8 Preview
If that's what it means, well, seeing the code two years ago is a total non-issue where the setup is so basic and the majority of languages are new ones.

But your interpretation seems way too generous when he compares it to going into your house and stealing from you.
see https://ugolini.co.th/ugolini/microsoft-says-error-caused-ta...
or https://newsasia.co/microsoft-blames-accidental-human-error-...

this code change is in response to the fact that bing was not serving up results of the tank man image on the image's anniversary.

The Tienanmen square protests were protests for freedom, and censoring images does not seem very free.
They seem to mainly feature minor things like the ability to run FaceApp with other apps - that's very good, I hope they take time to stabilize the system instead of adding new features.
I think the answer to your questions and thoughts can be responded to with "It depends." Truly, these cases and their outcomes can not be predicted, no matter how clear cut they appear to be.

Here's a great summary of some of the best appropriation cases involving art, and their outcomes:

https://news.fordham.edu/arts-and-culture/top-10-cases-on-ap...
iCloud Mail to support custom domain
> However, decentralized immutability means that nothing can be done should an unintended action occur with your account.

All that's needed is an elegant identity system that privately ties identity with transactions so that only the stakeholders can share their transactions while the ledger itself is public.

That way "Decentralized Immutability" can co-exist with mutability through law in case something terrible happens. You don't need to change the history, you simply need to make a court order to create an additional transaction that reverts the disaster. Just like how when a hacker gets caught stealing money, they are forced to send the money back (additional transaction) instead of deleting the original stealing transaction from the bank account and rewriting as if nothing happened.

The thing is, pseudo-Turing complete blockchains like Ethereum (and all EVM-like blockchains) are not really fit for this purpose because the entire logic is on chain. UTXO based blockchains like Bitcoin is optimized for this since each transaction can act as evidence trail.
I actually really appreciate that he wrote this post:

1. What if I'm considering working for Replit? This behaviour would give me second thoughts.
2. Imagine I'm a VC firm deciding whether or not to invest in them. I don't want me money being used to pursue a frivolous lawsuit against a website that isn't a commercial threat and probably isn't using their IP anyway.
You are right. Other than the brand name recognition and the existing business relationships, I can't think of anything that would be tough for a funded competitor to replicate.
I'm not sure why the actual people who did this aren't held accountable instead.
Ask HN: Is HN Down?
I got many errors:```We're having some trouble serving your request. Sorry! ```
All interesting; however the quote attributed to the dying Caesar is 'Tu quoque, Brute, fili mi?' (You too, Brutus, my son?) and not 'Et Tu, Brute?' (And you, Brutus?). I understand the space constraints for the title, but after the murder also the misquotation for the poor Caesar is too much – or, nimis multum, if you prefer.
That seems to be a mostly orthogonal concern -- you're talking about a general issue of "doing business with big corporations" and not really something I would say is specific to any given project. One way to help improve the situation would be to help them win those battles so they can negotiate for more time to upstream useful things.
For me it's the displays. Old laptops had terrible TN panels and are painful to look at today. It makes them near useless even for basic web browsing.
Having done this kind of support before (mixed hardware + software), a large number of people present their computer with multiple vague problems that can very well be a set of issues with both the actual physical hardware AND with whatever they have done to their actual user account on their operating system.

Most want all their problems fixed with as little action required on their part as possible, with as much certainty as possible, and do not care about security in the least.

People are hard to reach once they are out of your sight, and get very unpleasant when things take a while....even when they take a while largely because they didn't get back to you in a timely manner (because you turn out to actually need their password to troubleshoot their configuration).

"Wipe the device and start fresh" is understandably not a valid solution to most users (especially as anything other than last-resort), even though it'll rule out a large portion of potential software problems.

---------

To note on some other elements I see in this thread:

- Hardware diagnostics exist in some form on most devices. They do not catch every problem that exists, and are often especially bad with more intermittent issues. If the complaint is that Facetime drops out after 10 minutes, the most certain you can be that the issue is resolved is by running those diagnostics AND booting to their actual user account and having Facetime work for 15 minutes. No one cares that "it passed the Camera diagnostic" when they've still got a problem when they get home with their "fixed" device. Many people actively want you to be signed into their account and do exactly what they did to confirm the issue no longer happens.

- IIRC you can't actually boot a modern (T2) Mac to an external drive without an Admin password being entered at least once to change the Startup Security Utility settings.

- Whether being run as a business or as internal support in an organization (more so a college or the like with personally owned devices), time matters. Getting credentials from everyone who's willing regardless of if they turn out to be necessary is absolutely terrible security practice, but great for turning around repairs more quickly and with fewer repeats of devices coming back because the issue isn't fixed.

--------

tl;dr - Sensible security practices are at odds with everything else the average person wants from their computer repairs.
Lvh.me is not resolving to 127.0.0.1 anymore – security issue?
Many SQL tools that use JDBC have support for CSV, TSV and other table-in-a-file data stores (e.g. DBF).

I use DBeaver for nearly everything SQL. It is also open-source.

Create a New Database connection, choose CSV, choose the folder with the CSV files, and you will get a database connection to a "database" where each CSV file is a table.
M.2 drives are still removable in the X1 Yoga Thinkpads. The notable difference from thicker T series is that RAM is soldered.
Crypto is cool only because prices went up.
If price falls nobody cares.
Maybe HN suffered from the HN kiss of death.
Apple “Universal Control” Demo [video]
Worth mentioning that, at a minimum, he is an astronaut specifically chosen and psychologically trained and prepared for a multi-year to mission to Mars. He shouldn't have normal human reactions and given that his situation never turns truly hopeless, he has been trained to keep working the mission as well as he can.

Also, though he is isolated, he knows everything he does and discovers will be eventually found, analyzed and made useful by NASA and future space travellers. All of this can provide a sense of greater social connection that can keep him motivated to keep going.
Look at those new "tabs" in Safari. Firefox probably knew...
They mean dependent types, in the Idris sense. Basically, types (not just instances of types i.e. the entire collection `int` rather than 5) are first-class citizens that can be passed to functions. It enables proof checking as well as so-called "type-driven development".
CEOs get very invested in their projects. It's pretty much expected. It's their entire life. Many of them have invested everything into their companies, and are terrified of failures (there's an awful lot of FAIL out there).

Different Principals have different ways of evaluating threats, and reacting to them. At first glance, this seems like an awful mistake, on the part of the Replit people (Can you say "own goal"? I knew you could!).

Maybe there's more to the tale than appears here, but it does seem fairly straightforward; assuming that the emails shared tell the whole story.

I hope that everyone finds a way past this, and comes out OK.

One thing that I will say, is that the OP seems to be pretty sharp. He's young, and maybe he reacted more quickly and naively than a cynical old bastard like Yours Truly would, but he has done a pretty cool job on his project. It might not be "ship-ready," but it sounds like a great demonstration of his capabilities.

Also, as Elon Musk shows, CEOs can cause tremendous damage, if they go off-script. Being a CEO of a public/funded company is a fairly awesome Responsibility. It needs to be taken seriously.

I'd say that this very thread shows the damage that can be done to the company. Having this pinned at #1 on HN for all this time is devastating. It's actually kind of horrifying. Like watching a slow-motion train wreck. A lot of Replit employees and VCs are going to take it in the shorts from this. He's probably got some 'splainin' to do...

I can't remember the company, but there's a famous object lesson of a UK CEO that destroyed his life's work and corporation, by mentioning an upcoming product too early.
small correction

example usage:

sed -n '/{\"hits\":/p' 1.json|json_reformat|sed 's/ //;s/\\n/ /g'|less

also

instead of entering ^M, we can use something like djb's "addcr" from ucspi-tcp, a simple program that adds a carriage return ("\r") to each line

here is a simple shell version of addcr that also removes indention

x=$(echo x|tr x '\r');
exec sed "s/ *//;s/$/$x/";

example usage:

stunnel -fd 0 <<eof1
pid=$HOME/1.pid
foreground=no
[ $$ ]
accept=127.0.0.21:80
client=yes
connect=graphql.example.com:443
sslVersion=TLSv1.3
eof1
addcr <<eof2|nc -vvn 127.21 80
POST /v1/api HTTP/1.1
Host: graphql.example.com
Connection: close
Content-Type: x-www-form-urlencoded
Content-Length: $((${#@}+141))

{"query":"$@"}
eof2
cd;kill $(cat 1.pid);**
FTC Says MoviePass “One Movie Per Day” Promise Was a Double Feature of Deception
You should checkout Teaching Python Podcast run by two teachers teaching Python to middle school kids. https://www.teachingpython.fm/episodes
Would be rather interesting to create sth like bloom filters from ones DNA to find relatives. In contrast to phone numbers the DNA space here might really be big enough for private "contact" discovery to work ...
What I find kind of funny is

>Writing complex software without bugs is impossible.

I agree it's almost impossible to acheive bug free code (let alone unexploitable code that an adversary can experiment with) but look at crypto. Now go look at any industry where safety is important. Automative. Aviation. Look at the procedures in place for putting software in an ASIL-D application or take a look at the mind-numbing procedures specified in DO-254.

It's not like these guys are actually making any attempt to actually write bug-free applications.
This is seriously underwhelming.

I've been sitting on $2000 on an Apple gift card I wanted to spend on a top spec M1 iPad Pro to watch TV shows at home and take with me on travels if I need to debug issues in production or come up with a quick fix while sitting in an hotel room or a coffee shop. I was hoping iPadOS 15 would get the device closer to a Mac or make running Docker or VSCode easier without jumping through hoops with VPSs, but alas, seems like Tim Cook doesn't care that he's got a tablet that's incredibly fast, more so than most laptops, and that it's kept back by its amateurish operating system. Does "Pro" mean anything at Apple anymore?

I have a powerful desktop I love, and no mobile computing device are worth my money these days. I don't need a laptop with full keyboard and trackpad when I have a $5000 desktop at home and work outside 2 days a month; tablets have crap hardware if it's not Apple, or have the least powerful OS if you want to stay in the walled Apple garden.

I'll use the gift card to buy my mum and I an iPhone 12 and I'll get an Android tablet with a crap CPU that lets me run whatever I want. I hate having to compromise.

EDIT: clarified why a laptop isn't a viable alternative for me
The menubar looks oddly off-centered vertically. Is this a new style?
Well, I am guessing you are not an MD and as such you do not understand what radiology really is as a profession. You certainly have a very advanced technical knowledge about it, even much more than most radiologists. And that's precisely the catch: why are radiologists (mostly) non-technical people? The only possible answer is 'because what's asked of them as professionals is not technical'. As many (all) other specialties, radiology is more art than science. Its the science of interpreting images in context, and you can't separate the two.

So actually, radiology startups all fail on this crucial issue: to do a good job, you'll not only have to automate image interpretation, but really automate that of the whole EHR. And given the amount of poorly encoded information in there, machines fail now and will continue to do so in the foreseeable future.
The real irony is this protection is a complete fantasy by the crypto community. Business still operates in-the-real and is still subject to legal action. It doesn't matter how irreversible the block chain is if you can be sued.

The only difference at the moment is people are using crypto to skirt long standing consumer protections. Merchants naturally have more power in court than any individual so the power has really shifted away from the consumer.

But again, the legal system is king. It doesn't matter what the computer says.
> Where does this money come from? Increasing prices?

Shareholder reserves. Or do you think they have trouble paying for their groceries? Some wealth inequality can be fixed rather painlessly. I think we can all hold our collective tears that they won't get $10M yearly bonus and "only" $9M.

> What kind of life would that be?

That's not for you or me to decide to don't impose your life philosophy on others. For the record I too can never sit idle but I am not judging others that can and do that all the time.
The irony of course being that the soviet union was no stranger to antisemitism (an heritage that a lot of modern leftist organisations perpetuate).

https://en.wikipedia.org/wiki/Antisemitism_in_the_Soviet_Uni...
What do you mean incremental?
My grandfather used to tell me how one time he "flew" with his "bed" when he was there ;

How he woke up safe on his bed in the middle of the courtyard ; There were walls when he had gone to sleep before, but the walls weren't there anymore.

When I became older, I learned that fifty prisoners in his barrack had died this night.
How does a 3rd party (a court) make that transaction happen without either physically compelling the criminal (not necessarily possible in other countries), or having some kind of master key (which breaks decentralization).

With a bank, they have a financial incentive to stay a part of the international banking system at least.
From the readme, I can't exactly tell what this is for, why I should use it, or how I should use it. Instead the readme is an expression of the creator's ideology. Nothing wrong with expressing that, but without anything concrete to look at and help me understand this project, it just sounds like another ideologically motivated project looking for a use-case.
Do you know what particular objections he had against contacts?
Any way I can easily try this out without a signup barrier per https://news.ycombinator.com/showhn.html?
Just pulled 'new' and sorted the ages of new posts:

50 50 51 51 51 51 52 52 52 53 53 56 56 57 58 58 58
49
35
21 23
12 14 14 18 18 18
0 3 8

I'm guessing something happened at around t-49m (UTC 19:00-ish).

It seems to be more stable if you're logged out.
Amazing move by apple
The discussion on the new Notepad++ release already saw some discussion on this:

https://news.ycombinator.com/item?id=27420726
Even so, the fact that Repl.it felt so threatened by it as to threaten legal action and bully someone into taking it down speaks volumes to its viability as a competitor. The inability to scale can be fixed - probably not trivially, obviously, but it's very much a possibility.
Logicboard.com – Online Collaborative IDE
Eh, I wouldn't be so sure. Just because no one has found it, doesn't mean it's not there. There have been major exploits discovered in widely used applications that had been sitting there for years (Heartbleed comes to mind). While you can certainly be more confident with older smart contracts, that confidence will never reach 100%.
There's a privacy carve-out for stores and selling items because you effectively have to provide this information when paying with card for fraud prevention (both online and for in-store loss prevention).
Apple brings Safari web extensions to iPhone and iPad
> But visual art remixing textures feels more grey area to me than copy/pasting code or someone's writing.

Artists use reference material all the time, and as long as the new work is the product of the new artist, it's all good. But directly copying art and then modifying it is still copying copyrighted material.

My understanding is in the music remix world, if you want to feature a song in your remix, you should get a license.

Similarly, my brother makes AMV videos and as I understand from him, the music rights-holders (not the anime rights-holders, interestingly...) will then claim all the monetization on those videos.
The lack of search engine competition - viable alternatives - remains a rather massive problem in tech. Notepad++ doesn't have much in the way of options, unfortunately.
Newton's Method for Finding Roots
I love Jitsi, the main part being that I don’t need an account. It has always worked well for me, we use it for “virtual happy hours” and well it’s user friendly enough it seems to be a big enough hurdle the not so technical saavy seem to not get. There is an iOS app, or you just use a browser. I guess it’s normally the problem of making sure people enable their camera and microphone. Any who, FaceTime in browser seems like a big win for most people. People generally know how to use Apple things.
Would it be against HN's rules to reply to Who's Hiring posts from Replit with a link to this article?
>forcing someone to create an account that uses their phone number and installs an app on their device

If I had any choice I would decline to join a whatsapp or signal call.
I think I am going to make Riju clone next weekend, got a name even: Disreplty.
actual deaths from the actual abuse of authority,resources,and weaponry, there is a reason why such weaponry as a bola is illegal to possess, despite the expedience of construction. discharging/throwing a bola at the head neck chest, is how you inflict fatality.
this is not supposition, you can have a friend help you to find out, in your own backyard, i would expect your friend will have to post the results in your stead
I mean nothing is 100% secure, including our current financial system. There's non-zero chance that the whole system could collapse tomorrow (even worse than in 2008).

Also, big difference wrt to something like heartbleed is that any exploits in these smart contracts will be known immediately when even the tiniest amounts are moved.
US has recovered ransom payment made after pipeline hack
I would add a comment, but HN is down.
These hacks have always happened, the difference is that, in the past, the users data would get sold on the black markets, now instead these hackers can get paid directly by the company more easily.

What you should blame instead is companies that can't do the bare minimum to protect themselves, that pipeline company for example didn't even bother revoking access from an ex-employee, literally bare minimum.

Also, this shows why crypto is the perfect currency for the internet and you'll probably be disappointed if you keep waiting for "the bubble" to pop.
If all the person leaving is doing is creating the same thing, it's unlikely to be worthwhile. You'd be competing against an entrenched competitor with a customer base and brand recognition. What makes it worthwhile is if you want to do something different that they're unwilling to do.

For Zoom, that was to market the product to random people for free or close to free because the cost to provide it had fallen enough to make it worth while.. WebEx was unwilling or unable to do so. I'm sure it was suggested many times. Probably even by the soon to be CEO of Zoom before he left to do it himself.

Sometimes the original company is worried about cannibalizing their sales, or shifting focus from their current customers, or it's just plain a case of them moving far too slowly to take advantage of the market. These are all cases where someone leaving and starting a new company to serve this demand is a good thing for consumers, regardless of whether it's good for the original company. Companies that can't respond to market needs are inefficient, and in a well functioning market suffer for that.

In a poorly functioning market, such as one with overly onerous regulatory hurdles, or litigation preventing competition, or customer lock-in, customers are given fewer choices and competition is constrained. People taking their expertise and making new companies to serve different segments of that market is a feature, not a bug or problem. It's how the market works. If repl.it is worried about a hobby project that can't scale and doesn't seem to be attempting to compete in the market, how much value is it actually providing? Threatening litigation says a lot more about their product than the competitor, IMO, and what it says is not flattering.