skysight-inc/HackerNews huggingface dataset:
In this Twitter thread Immunologist Kristian G. Andersen is addressing similar claims about the Furin cleavage site and the use of CGG codons:
https://twitter.com/K_G_Andersen/status/1391507230848032772

According to Andersen, the CGG codon isn't quite as rare in coronaviruses. He also comments that the stability of the CGG codon in the Furin cleavage site has been remarkably high over the course of the pandemic, which is a hint that the CGG codon may be selected for and crucial for the virus.

Quoting him:

> Now, the codons. Here, Baltimore is talking about the two codons coding for the first two arginines (R) following the P - CGG. The CGG codon is rare in viruses because it's an example of an unmethylated "CpG" site that can be bound by TLR9, leading to immune cell activation.

> Despite being rare, however, CGG codons are found in all coronaviruses, albeit at low frequency. Specifically, of all arginine codons, CGG is used at these frequencies in these viruses:

> SARS: 5%
SARS2: 3%
SARSr: 2%
ccCoVs: 4%
HKU9: 7%
FCoV: 2%

> Nothing unusual here.

> Furthermore, if we go back to the FCoV sequences and compare them to SARS-CoV-2 at the nucleotide level you'll see that FCoV also uses CGG to code for R immediately following the P. The next R is CGA (non-CpG) in FCoV, while it's CGG in SARS-CoV-2 - one nucleotide difference.

> We see CGG multiple times in different ways - here's an example comparing another "PR" stretch between SARS-CoV-2, RaTG13, and SARS-CoV in the N gene. Note how SARS-CoV-2 and RaTG13 both use CGG, while SARS-CoV-2 uses CGC for the first R, while later R's are coded by CGT or AGA

> One final point about the CGG codons in the FCS - if they were somehow "unnatural", we'd see SARS-CoV-2 evolve away from "CGG" during the ongoing pandemic. We have more than a million genomes to analyze, so what do we find if we look at synonymous mutations at the "CGG_CGG" site?

> Remarkably stable. Specifically, CGG is 99.87% conserved in the first codon and 99.84% conserved in the second.

> This is very strong evidence that SARS-CoV-2 'prefers' CGG in these positions.
My fault. In that case those statement are perfectly fine in my book. Thanks for pointing it out.
Apple's tenure is over. They are the definition of rent-seeking incumbency.
Yes, but that code wasn't mine either as I wrote at another company as their product. When I added my "hidden" traces I did that with no intention to claim ownership, but rather to leave a signature just in case. Technically the 1st company should have sued him, but I can't know for sure the details; the old project was then dead, and he could have purchased the sources legally, although I doubt that.
searching "tiennenman square" also results in a suggested narrowing search which includes "tank man" at the end
At least in jurisdictions that have abolished capital punishment.
How to Outsmart the Smart Devices and Take Charge of Your Focus Time
Exactly, there’s a dollar value to you that they’re not paying you. You’d need a “property right” over it. (You are your own “property” already anyway.)
I think this is a reasonable question. Usage based pricing seems like a trending topic lately and I hear Slack called out as a good example. Monthly seat licenses were a practice that existed long before more obvious "usage based pricing" models became prominent.

I'd love to hear more thoughts on the topic.
Why does the asset class matter?
That's what the article is about. Basically the federal hacking law defines computer crime as "exceeding your authorization" on a computer that didn't belong to you. Hence violating terms of service would be computer crime.
He was lucky. A family member spilled water over her beloved 6 months old iPhone 12, it leaked in and caused stains on the display.
Advertizing needs to be pull, not push. That is, when I have disposable income and am looking to spend it, there ought to be a place I can go to browse ads.

Otherwise, get the fuck off my attention span, stop bloating the web, and stop polluting public spaces with irrelevant information!
It enables Amazon devices to transparently connect to amazon with near zero user configuration as long as the device is within range of an authorized AP or another sidewalk device owned by anyone. This makes Amazon devices to "just work" in more places and most users will love it because they don't know and/or don't care about the privacy and network security implications.
They didn't need it but made use of it anyway. This is not a matter of rules, but of ethics
This is demonstrably false. There was no coup attempt, only a peaceful protest.

The protestors were happy to remain outside. There's video evidence of Alex Jones using a megaphone to tell the protestors to walk around the building to the other side, specifically not to enter it.

The protestors were allowed into the building by Capitol Police. The Capitol Police opened the doors for them and ushered them in, offering no resistance. There's video evidence of this as well.

The only casualties were Ashli Babbitt, who was murdered by a still-unidentified member of Capitol staff, and those people who were assaulted by Capitol Police the following evening after the cameras were turned off.
NetLogo is moderately popular today. I've seen it used in academic contexts for modeling cellular automata and agent-based simulations: https://ccl.northwestern.edu/netlogo/
He's not censored. He had a blog that no one visited and it went away. He has plenty of outlets to disseminate his message.
Out of interest, have you read https://www.techdirt.com/articles/20200531/23325444617/hello...?
It is no where near as common on Facebook as say Twitter, but here is an example

"Why do the people of conscience around the globe say "Death to America"? What do they mean? To the newly elected president of America, Donald J Trump, we say, dear Mr Trump, DEATH TO AMERICA!"

- Ayatollah Khamenei

https://m.facebook.com/khamenei.updates/videos/2205424783776...
Analysis reveals global ‘hot spots’ where new coronaviruses may emerge
And they have an API to these data. Selling your data to data vendors.
And now this:
https://www.melissa.com/industries/healthcare

Health records used for AI machine learning training . Your health data are in the vendor database . What possibly could go wrong?
Going fast is one thing. Making a program that responds consistently is different, and there's a continuum of choices. The last time I read about Go's GC they targeted 500us and for tons of applications that's more than sufficient; for some, it's not.

You could start with twiddling some of the GC knobs Go gives you, but you're still working against an SLO. If you need stronger guarantees you'll look at languages that completely eschew GC, because Go's GC still has STW bits. Climb the ladder further and you're reducing allocations, eventually avoiding any malloc() beyond what it takes to get an arena and doing your own bookkeeping. I've never been near the top of the ladder when you have hard real-time constraints, but I've heard it involves paying Wind River for VxWorks licenses ;)
How about they stop spending money they don't have that I'm responsible for?
Pie menus are better than hamburger menus!

https://www.youtube.com/watch?v=tMcmQk-q0k4
Not only that, there is real money made in in-store product placement (end caps) etc.

Less foot traffic, less money.
I’m not sure how you think Swartz is diefied.

He’s certainly responsible for his actions, but they were not wrong, I think. And he was obviously unjustly persecuted for his actions.

I think it’s accurate for us to celebrate SCOTUS ruling that the way the feds prosecuted Swartz was wrong and recognize that it will help prevent future Swartz.
> Also, fact is that matching consumers with products that they like doesn't just have enormous business value, but is actually socially positive! If you can more easily reach a niche audience, you can build better more targeted products.

Maybe this works well for some products, like "I know i need to buy milk, what should i buy?" but it has often been used in a form that appears like an abusive relationship.

Think about all of the kid-targeted ads from 30 years ago which peddled sugars and psychological tricks to get kids frothing at the mouth over their food and toy products. These weren't merely advertisements, but targeted attacks to the brain. And of course things haven't changed, it's just iconic to talk about early TV's cereal commercials hah. As with many product advertisements, they're not just trying to make you aware of the product - they're trying to bypass your consciousness and hook straight into your brain.

That was 30 years ago, and we've had the misfortune of seeing this evolve. Now social media advertisements are hyper targeted with similar tactics but more nefarious goals. Misinformation at the hands of targeted advertisements has been the source many-a controversies of recent years.

My point is i'd agree with you if advertisements haven't been so blatantly manipulative over the last 50+ years. If they were simply "Hey, you like X, try Y?"; but they're not. That ship sailed before i was even born. And it's only gotten worse with time.
I would argue that value is based on some sort of emotional measurement. The idea that a mass produced good, that is a physical item.. is only valuable because of the ability to hold it and the emotion behind it.

whether or not digital good carry that same weight, is left to be seen.
It helps with being able to measure whether you're advertising to the right people. Traditional mass media advertising made a lot of money off of showing ads to completely irrelevant people. Targeted advertising makes even more money off of showing ads to mostly irrelevant people.
Don't underestimate the egos of doctors and how each one has "their way" they want patients to do exercises.
AOC and other folks on the left aren't actively trawling for people to overthrow the US government or overturn elections.
Hacker News discussed an essay, http://www.paulgraham.com/newideas.html

I took footnote five as a book recommendation, and bought a second hand copy of From Galileo to Newton

Fascinating stuff. Right from the start, with the Royal Society being set up in 1660, money was a problem. Gentleman amateurs couldn't afford to keep skilled craftsman in their employ, building air pumps, blowing glass barometers and the like. So they looked for government patronage.

But to return to the question, I experience some synergy, with blogs and HN stimulating my curiosity and prompting me to buy and read books. Online is not entirely distraction and time wasting.
But, if I understand correctly, by definition an employer would have no expected direct benefit from hiring at this salary. Are there any for-profit employers who use such a calculation in-practice coupled with some fixed multiplier (or multiplier range) for all their roles?
https://twitter.com/AliAbunimah/status/1396362010963726339
I was wondering what made HN special, aside from its user community. The simplicity and self-governance model are atop that list.

In other words, what if HN was a subreddit? There is actually a parallel one already set up: https://www.reddit.com/r/hackernews/
I don't know if I'll ever forgive Google for killing blob emojis
China blocked candle and cake emojis from Weibo
He also exposed crimes against the constitution that afaik no one has answered for, yet he himself is effectively banished to a dictatorship.
Agree completely, but I can tell you for many of them pirating a text book is beyond their means. To do so you need not only internet access, but the sophistication to find pirated text books, and THEN the means to print possibly hundreds of pages. There is a big difference between poverty in the West and in a place like South Africa. Just printing the text book would be prohibitively expensive.

Source: am South African.
Too late. You already clicked "I agree" on that EULA.
>Working class shoppers. Sure, it’s elitist, but people like shopping alongside people in their own stratum.

Elitist or not, wouldn't this advice simply move them from one stratum to another?
https://www.reddit.com/r/magnetfishing/
"Opinionativeness is the lust of conquering" Augustine
Would like to see more info about what exactly they said about bonuses and to whom. The article only mentions it in passing
No evidence UFOs are alien craft, unclassified US intelligence report to reveal
SEO software startup Moz acquired by iContact Marketing, 17 years after launch
> I'm all for curiosity about life and exploration, but for a lot of games a flat field is simply better, and those games have tons of value. How well you work/interact with other people has a huge impact on life, and active play directly develops those capabilities.

This is... reductive. I didn't play any organized sports as a kid, but I don't have trouble working with others. On the other hand I've met plenty of people that played sports all through primary school and they're utter assholes as adults. This narrative is also often used to justify why schools often cut funding for science/arts before cutting sports. To my ear it sounds like someone justifying why their preferred childhood activities were better than someone else's preferred childhood activities.
Historically, less kids are born during war times or other crisis times. People avoid having kids in dangerous situations. And if you have baby in Stalingrad, you are significantly more likely to die or get raped etc. Along with the baby.
It's also makes business sense to use virtual characters.

If you are a streamer whose sole income is based on sites like twitch/youtube, getting banned could mean the end of your career and social life. Many streamers live together and collaborate with one another and sites like twitch have rules where you can't stream with banned streamers. So getting banned doesn't just mean getting banned from the site, it also means getting banned from your friend group because interactions with you could get them banned too.

With virtual avatars you could evade a ban by changing your model and also use a voice changer. I haven't personally heard of any cases where streamers use virtual characters to evade bans but I'm sure its at least happened.

It also becomes easier to become a marketing tool. Since Code Miko isn't a physical entity, she could easily be used in video ads just by sending ad agencies her model. No more flights to video shoots, all you need is a 3d animator.
I'd argue it doesn't matter. If Taco Bell kicks you out of their store for breaking the rules, you can't sue them because the taco stand down the road isn't a "valid alternative". There were rules of engagement, and you broke them. Since you are the person who violated the contract, you're objectively the guilty party: the extent to which Facebook can punish you is only limited by how invested you are in the platform.
> if people like shopping alongside people in their own stratum, then they have to accept that they have to pay a premium for it (i.e. shop at Whole Foods).

I agree that Walmart can be extremely unpleasant compared to a regular grocery store for many reasons.

However, I’ve found Whole Foods staff to be extremely unwelcoming unless you seem like you fit in regardless of how much money you make.

Can definitely recommend wegmans for a more upscale shopping experience (Eg fancy cheeses, meats, selection of fish) without any of that “too cool for school” factor if you’re not in an “in” group.

Edit: Trader Joe’s is also pretty cool but it reminds me a bit of Aldi.
This is a great list. SO many times people have said to me, "Let them track me, I've got nothing to hide." And you hit them with a few things off this list and they immediately change their mind. There should be a tinurl for website I can send people to that shows a simple list of all the ways personal information can be used.
Simply assigning a price to an activity doesn't solve the ethical and moral issues that can arise from that activity.

Having a price for something doesn't exactly help victims of human trafficking (whether the illegal organ trade, prostitution or anything else). What can help those victims is regulation and aggressive criminal prosecution of anyone who seeks to gain from the suffering of others.

Unless people actually have a realistic and practical way of "revoking access" to their data which results in serious penalties for companies which continue to use said data (including company-destroying or even criminal penalties for senior managers/benefactors) then the negative-externalities of data-collection won't ever really be curtailed.
Let's not do the criminals' jobs for them.
Yes they can just pay in monero.
> So Aaron's other suicidal episodes, when no one was prosecuting him, aren't relevant to his final suicidal episode?

They absolutely are. Suicidal episodes are usually kept quite quiet - people you're extremely close to may have attempted suicide without ever telling you about it due to the societal shame and perception of weakness.

As a general rule, it's a good idea to not emotionally abuse people or induce unnecessary mental stress on anyone since you're not going to be aware of how they're doing internally and, honestly, trying to emotionally abuse people, even when they're able to take it, is just being an abusive ass.

I think your example of flipping a bird on the highway is honestly a good thing for more people to keep in mind in their daily lives - if someone is feeling particularly vulnerable then lashing out at them could tip the balance and you don't want that on your conscience - but I think legally speaking it'll always be a matter of judgement on the specifics. In the highway example it's likely that your bird barely nudged a needle that was already on the brink - while, when it comes to the legal system, prosecutors regularly use emotional abuse to expedite confessions and coerce defendants - as a society I think we tend toward a view where once someone is charged with a crime they are segregated into a different class of people who are unworthy of common respect, we need to change that.
More research is good, and if this means both approaches live side by side that's good.

But the directed approach already exists, and it's stupid. It just leads to lots of grant requests that are super far fetched and suddenly one year is all about cancer and the next all about space and the next all about computer, all the while it's the same research.
And they had 6 billion in cash on hand going into the pandemic
Hey. I write Elixir & Erlang sometimes too. I'm an Erlang Ecosystem Foundation member.

There are very real and well-known scalability limits of Erlang clusters and applications that run in them. This isn't someone talking shit, but instead just operating within the limitations imposed by reality. Message passing has overhead -- it's not free.

WhatsApp probably doesn't need nearly as much hardware as you think.
Does the Internet Prove the Need for Government Investment?
> These days if it's more than 5 lines of code, or if arbitrary filenames are involved I go straight to Perl or Python

Totally agreed. A shell script exceeding that's about 10 lines of code becomes so complex to read, interpret and improve that even though it may perform faster I would rather get the job done in a language that I can understand better when I come back to this 3 months later.

Although ... on that note I don't think I'd ever choose Perl ha ha.
The premise is slightly different. I'm mostly differentiating between cookie tracking and social networks (and some other large online platforms). The large online platforms don't need to track you - you give them your data willingly. Facebook knows a lot about you not because it's tracking you, but because you keep posting things to it. Cookie tracking is an alternative way to build up an effective advertising profile that is decentralized and anonymized, which I think has some value.
I would not be surprised if the recent upticks are directly correlated with privatized prisons.

There’s a corporate interest right there! Having some experience from within (healthcare industry, original DRG implementations and TEFRA), I can say that not everything you can get Congress to implement (at the behest of lobbyists) works out beneficially for your particular corporate or industry interest.
CCC has a longstanding policy demand called the "Datenbrief" ('data letter'). Under this proposal, every corporation that keeps personal information about a natural person would be obligated to, once a year, mail the subject a letter containing their information, with instructions how to exercise their existing statutory deletion/correction rights.

If you keep PII, you'd also need to keep some contact info for the subject, and use it to ensure they know about their rights / the data. The existence of the data-related right would imply an obligation to inform the subject about it.

I guess I'd prefer a web interface displaying all the data holders with little "delete" buttons, over getting a gazillion letters, but if this is implemented by a single organization that actually has all your data (even if only for the purpose of faciltating GDPR), it could be a central point of failure.

[1] https://www.ccc.de/en/datenbrief
Stellar works really well - you can just have users input a stellar address or make one for them. They'll need some sort of crypto exchange account to withdraw, though.

You can send USDC or native XLM. There's a nice JavaScript API and you can even batch payments up into one operation. Fees are negligible.
If I was evaluating a free product I'd be wary of getting locked into it and then discovering missing features that I would have to pay for. That is essentially your business model, but even paying for a product I'd be wary of lock-in these days. Software can be complex enough that you don't discover missing parts or find the API is written in such a way that moving to a different platform is impossible without starting over, long after your business depends on it. So how does anyone know the product will remain free forever, is it open source? Can I fix problems on my own or will I have to pay you? Part of your marketing should be to show how those who try the free tier won't be locked in so when they grow they have a choice of buying from you, other vendors, or doing it themselves. Basically you are giving away a horse, but potential customers realize you have an ulterior motive and hence are going to be very wary of your gift horse.
Science, tech and infrastructure is what separates us from cave men. You are confused.
"one of one" or "one by one"?
I agree, and this probably isn't good; but, I want accuracy in what's being said when it comes to censorship. We shouldn't win against censorship by hyperbole but by the unfiltered reality being so horrible that people wouldn't want it, anyway.
It’s far more likely that the plants and animals moving in are invasive, not native. In my garden in California anything native is the exception.
Suspends Twitter Operation... Then uses Twitter to publicize the announcement. Ridiculous
The thread could have been flagged because 50 people clicks "flag" in the first few minutes.

Dang was working 12 hours ago, he's likely off at the moment.
It's pity we're excluded from Freedom Tracking
For First Time, Drones Autonomously Attacked Humans: UN Report
That may be, but they'd be wrong.
So, basically they are saying they don't know what the hell they are.
However, Amazon is a US company. So while it may be bigger, it's not in Europe "per se". OTOH, OVH is a European company since it was found inside EU borders.

So, OVH may be the biggest cloud provider in Europe, since it's a European company.
They promised to protect jobs and no bonuses in return for state aid.

That's exactly what they didn't do. They laid off 5000 people and got bonuses.
Don’t expect that with big corporate hoarding it all for you. It’s “their infrastructure” and their business.

The west wants to be free of life’s problems while also being free to optimize time to avoid dealing with them.

It’s almost as if physical reality is full of real constraints our imaginations can refuse to acknowledge.
It was fine except for the sausages were pretty gross.