skysight-inc/HackerNews huggingface dataset:
suggestion is to have a small link to a "pro version" coming soon or something so people know that there is a reason for asking for the email/more trust in the product
> 2b. the inserted furin cleavage site coding sequence is misaligned, breaking the codon TCA into two parts, which is (citation:) "very odd, clearly pointing to an artificial origin"

But what is odd about this? I don't know of any mechanism for mutagenesis, natural or otherwise, which respects codon boundaries. Codon boundaries don't exist in the DNA, then only arise through its interpretation by the ribosome.

On the contrary, if i was engineering a polypeptide to add a furin cleavage site, i probably would align it to codon boundaries, so as not to disrupt the sequence.
This is oversimplifying it a little.

Yes Baratzas are great grinders but they are not one-size-fits-all depending on what kind of coffee you make. For example Baratza Encore is everyone’s darling with good reason (I have one and I use it for espresso every day!) but it’s not a great espresso grinder because fundamentally speaking its tiny motor just doesn’t have enough torque to drive big burrs, so it has small ones. Which means when you grind at espresso sizes it’s going to lose its tight spread and it’ll output some grains that are too big for espresso, some are too small and some are just right. Since espresso is very dense coffee, this is something that is very clearly tastable even to a skeptical non-expert like me.

This spread of grain sizes is something to some degree any grinder does, but grinders designed for espresso have tighter spreads, so they provide much more of the size you want (so your water can actually pass through) and much less of what you don’t want.

Incidentally this is something I like about specialty coffee industry compared to other connoisseur stuff like wine. Wine experts walk around talking about the earthy aromas, if some coffee ‘expert’ tries to do the same, someone in the audience busts out a refractometer and says ‘aight, let’s see’.

It’s still a money pit, but it’s at least on a much more scientifically solid ground.
$30 per hour is way more than a $30,000 salary. Technically $30/hr is double that - roughly $60,000 per year. If you are a full-time employee in the U.S. then typically other benefits such as health insurance, 401k, vacation time, etc will be factored in, so typically if you were interviewing a U.S. citizen for the job, then whatever “hourly rate” the salaried employee would be at ($60k salary ~ $30/hr) should be multiplied by something like 1.3 or 1.5 for a contractor rate to account for the employee benefits they are not receiving from you. So $30 would become $40+ instead for a contract rate.
It’s not so much the apps as the system frameworks they’re built upon, which are still almost universally Obj-C (or some other C-family language). Even if every third-party or user-facing first-party app was 100% Swift, there’d still be massive wins from speeding up objc_msgSend.

(Not to mention that even pure-Swift apps use a lot of Obj-C-isms when touching said system frameworks, like the target/selector setup for most UI controls).
The counterargument mounted by Wade and others is that the world has been searching for such a transmission path for the last year with far greater resources than normally allocated, as obviously, China would very much like to find such a path. However no such animal has been found. The lack of any discovery despite great effort is not itself proof, as you can't prove a negative, but it does seem suggestive.
> But the video game itself is only $15 and is probably more fun.

I tried it on iPad and was instantly overwhelmed.

I did not know that after 2am I'm falling unconscious. I felt I walked out of my farm plot into town and back, and the day was over. Which it was only because I didn't find my way back to the farm. Is there really no marker on the mini map where I'm standing?

The next day I learned to fish, spent all my money, in order not to starve, and decided that the game was no fun for me.

Maybe with a gentler onboarding it would have played out differently, maybe I'm just not the type for it.
I would just say tough it out. Who cares if you aren't living up to your potential? Most people don't. I'm tired of people always expecting more from me.

"The cloud and countainers and all the programing fads and stuff are actually becoming off-putting to me. I see the space (CS / SE) as increasingly over saturated with bullshit.

This puts me off from wanting to learn more and try to find work in the sector."

Me too. Whenever I learn stuff, it just ends up being one time use, throw away. Why bother learning it?
I'm not talking about Southwest banning them from Delta, I'm talking about why say, Delta doesn't decide they do not want known violent passengers?

Injustice anywhere is a threat to justice everywhere.
> What we especially need to stress to regulators...

Lol. Talking like that obviously shows that cryptocurrencies are not for you. This tech has cypherpunk and crypto-anarchy roots, regulators/governments are not the intended users for this tech, even if you like it or not. If you do not view cryptocurrencies from an cypherpunk perspective you will not see their social benefits, it is an entire way of life an alternative view from the centralized shit show we have now. Yes the tech has flaws, just like how digicash, hashcash, b-money etc had flaws, this is an evolutionary process and nothing you or your government says can stop it.
> Inflation isn't 2%

Okay, then what is it? Obviously you have taken the trouble to measure inflation because you know it's not 2%. So tell us, what is the inflation rate? And show us your calculations please.
A similar thing I've noticed a trend of recently in frontend react codebases is overuse of memoization. It seems as though people don't realize how it works and that it is often _less_ performant than just doing some low cost computation on each render (like a comparison or basic math).
That’s for 12 pairs.
Why Is the Apollo Reflector Experiment Still Operating, 50 Years Later?
What makes you think that criminals are not capable of centralization?
Is there any great mystery to their popularity? Surely it’s the same reason other franchises are popular - good promotion from the studio, a loyal fanbase that loves the familiar characters, and a wider audience that loves a brainless action-flick with attractive actors.
This is a rather odd and fatally incomplete essay. Its final suggestions, verging on explicit charges, of antisemitism against Fleming seem like guilt-by-association.

The criticism of the writing in the novels is not totally unfair. Although the worst of it is barely readable, at his best Fleming could spin a scene or passage with resounding skill. But his most interesting work is in his short stories, which Richler doesn’t mention. If you think you have the measure of Fleming, read the story “The Hildebrand Rarity”, which rises to the level of literature, and takes Bond to psychological places that may surprise you. Also, in stories like “007 in New York”, Fleming shows real wit and something like self-deprecation toward his own output, or at least the ability to have fun with it.

Finally, although Richler runs on quite a bit into anecdotes about Fleming’s promotion of the Bond books and their commercial fortunes, he doesn’t mention what caused the sharp turning point in their popularity, which was a comment by JFK.
Protection groups. Stuff like attorney general, BBB, CFPB, etc.
It is probably illegal if they have a monopoly market share. But they don't, so it probably isn't. They have a large market share, but are very very far from monopolizing the entire retail market.
> nothing you or your government says can stop it

Oh yeah? Let's find out.
It's also sort of a bad idea to normalize drinking out of laboratory glassware. Granted your home is different from a real lab, but lab workers have died drinking something they thought was water.

In my dad's lab in the 1970s, they used to make coffee in a large Erlenmeyer flask and filter it under vaccuum with a Buchner funnel. The safety director eventually banned it and made them buy a Mr. Coffee.
These are untruths. Neither of you are moral.
> Modern life is far more mentally taxing and stressful

No, I'm not conceding this point. It ignores that our ancestors evolved large brains (note, before agriculture, _they were even larger_) to deal with a wildly complex natural environment. Knowing the details of the dozens of food sources necessary to survive. How to deal with different seasons. Which of hundreds of animals were edible, which would eat you, and which were fine to ignore.

Life was, in every single way, harder and more complex before technology. Trying to equate our comfortable and materially opulent existence with theirs is wrong.
I can't agree with your point hard enough. Really useful nascent technologies all have this pattern—they grow incrementally more interesting and constantly gain applications.

Bitcoin followed this pattern for a while. But then at some point it started to regress on that axis. You could no longer buy a pizza with it, you could no longer mine it, and it got too flooded by scammers to use safely. There's nothing to really DO with blockchain unless you buy into the subculture. That's very different from early internet, early web, early radio, you name it.
They don't serve the ad that is most relevant to you, or even the ad that you are most likely to click on, they serve the ad that advertisers are willing to spend the most on.
It's very hard to boycott a company into bankruptcy this way, and it never worked. Maybe a tiny startup, by scaring off backers. It's much easier to scare their PR HR to fire a person or do superficial changes. Companies have more power than a random employee, unless we're talking CEO level.
But this link isn’t criticism. It’s a quasi-religious two minutes hate, as every single topic on crypto inevitably turns into.

I guess it’s just a reaction to the constant hype being pushed by the crypto world. As a mostly neutral observer, I really don’t get it.

Regardless, this isn’t the point I was making. Crypto cannot be stopped. At best, you’ll have regulations against PoW mining.
I don't know why you have been downvoted, you do have a point. Algorithms are tailored towards specific purposes. If you for example have something that runs with an n of about 5, and it's not in a hot path, the clear concise solution may well be better. Besides, with small n there is more to the cost of an algorithm than just its asymptotic growth.

However, to the point of the person you've replied to: It's good to know that stuff to be able to assess the situation in the first place.
ah beautiful, i was hoping a cli-ified/updated version of the already wonderful OpalCalc would come into existence!
Protip: author interviews on broadcast media are almost always part of a publicity tour for a book.

Here, the guest, Jennet Conant and her book The Irregulars.

A YouTube search for longer-duration videos should provide a few talks based on the book. Or you could read the book itself ;-)

https://www.youtube.com/results?search_query=JENNET+CONANT+i...

Here's a 50-minute talk: https://www.youtube.com/watch?v=3w-iPz6brO0

You can also try podcast search (in your podcast app or online). A starting point: https://www.listennotes.com/search/?q=JENNET%20CONANT%20irre...

And another: https://www.youtube.com/watch?v=pWtDq5rWmmc

(I've listened to only a minute or so, it's highly likely the talks are near-identical.)

The book: https://www.worldcat.org/title/irregulars-roald-dahl-and-the...
Well, indeed, that is what their main finding is. The question is do they affect mood by means other than affecting circadian rhythm?
BB lost a part of an order, just a $3 thermal paste. Luckily the heat sink came with some. I couldn't dispute it with BB, post office blew me off, and since it was only about 10% of the order I couldn't dispute with cc.
we have weaponized outrage against our neighbors and it is absurd. weve gotten to the point where a hangman's noose is racist as is the OK hand sign, and it is now common for such simple displays to escalate to a federal case. we want kids to stop bullying each other in school, but ridicule, harassment, name calling, and ostracization are perfectly acceptable ways to settle disputes. if this is to change, we will have to tone it down, not pretend that someone is evil because of a single harmless thing that they said, and business leaders will have to steer their companies away from encouraging this childish outrage culture.
That limit sounds low, e.g. Chase Bank allows wire transfers out of $100,000 per day for individuals.
Until it affects me or concretely confirmed, what's the point in guessing about the stuff?
It just feels weird getting financial and social advice from Pinboard. I thought it was just a thing to collect my links.
'disclaimer', pet peeve coming up.

> Disclaimer, I'm a CTO.

That's not a disclaimer, it's.. a claim. It's not even a 'disclosure' (which is what people saying 'disclaimer' often mean) really, it's more like a 'source', or just.. remove the word?:

> I'm a CTO, here's how I evaluate [...]

Sorry, just bugs me.
Yes they went from counting interlaced vertical lines to progressive lines, to the number of 1080P pixels. The 4 in 4K refers to the number increase in pixel count.
I do not think it is basic and, in the field, hugely controversial. They tried really hard to keep that discussion inside the field, not allowing the general public to have a say in if they want to tax-fund the creation of pandemic-potential viruses in BSL2 labs. Stuxnet would be comparable to GoF coronavirus. Stuxnet also got out and hit Germany. Think they did that to research better virus scanners?

> The Director of the National Institute of Allergy and Infectious Diseases (NIAID) and the Director of the National Institutes of Health (NIH) have systematically thwarted efforts by the White House, the Congress, scientists, and science policy specialists to regulate GoF research of concern and even to require risk-benefit review for projects involving GoF research of concern.

> In 2014, the Obama White House implemented a “Pause” in federal funding for GoF research of concern. However, the document announcing the Pause stated in a footnote that: “An exception from pause may be obtained if head of funding agency determines research is urgently necessary to protect public health or national security”. Unfortunately, the NIAID Director and the NIH Director exploited this loophole to issue exemptions to projects subject to the Pause –preposterously asserting the exempted research was “urgently necessary to protect public health or national security”– thereby nullifying the Pause.

> In 2017, the Trump Administration announced a Potential Pandemic Pathogens Control and Oversight (P3CO) Framework that implemented a requirement for risk-benefit review of GoF research of concern. However, the P3CO Framework relies on the funding agency to flag and forward proposals for risk-benefit review. Unfortunately, the NIAID Director and the NIH Director have declined to flag and forward proposals for risk-benefit review, thereby nullifying the P3CO Framework.
>he wants us to transfer IP rights of the product (without any money paid) to a California general partnership entity in which his LLC company will have 51% interest and a managing partner status

Fuck that shit, and I'm really, really, drunk right now. I stopped reading at that point. Pass. Good night.
How do you move cryptocurrency back and forth to local currency you can spend?
Yes, indeed, nothing specific to Next. All components are written in React TypeScript and it should be easy to adapt to Gatsby.

I've built these themes in this mind, be compatible with all React frameworks like Gatsby and Create React App (unlike Next JS and Gatsby, CRA doesn't support static site generators out of the box).

Not only these template comes up with a design, but I also try to provide a better Developer Experience. So all these themes include JS tooling like ESLint, Prettier, Husky, Bundle-Analyzer, etc. I've chosen to focus on Next JS in this first iteration, which explains why I didn't provide Gatsby right now. If there is some demand, I'll definitively add Gatsby support, also with a great Developer Experience like the Next JS version.
Ten Problems for Gaming in the 2020s
Russia plans nuclear-powered spacecraft that can travel from the moon to Jupiter
> There were things to download, people to meet

Same with LAN parties. I was thrilled to buy my first network card, and a tee connector.

Even the fact that the first half of the day was mostly wasted with trying to get IPX and NetBEUI to work and TCP and UDP, and promising each other that we would not change anything until the next LAN party, and of course next time nothing worked either at first try. But it was fun nonetheless.

(The second half of the first day was obviously swapping all those music and video files)
The point isn't the power over the corporation, the point is the power over the individual. But if the law makes it so they have no power over the individual, the motive to boycott won't exist.
I love Costco return policy and we bought a lot of stuff there just because "well, if we don't like it we can just return it anytime" (and we did like it and never returned it) over the years, but I've seen some ridiculous returns there. From people treating returns as a zero-cost rentals to buying a tree, failing to water it until it's dead and then returning it. They still have very generous policy and I would hate to see it ruined by people who're just taking an unfair advantage of it and ruining it for everybody.
That post actually might have started a genre in Reddit.
Here's the next ones:

https://www.reddit.com/r/ExperiencedDevs/comments/nnw7yd/sob...

https://www.reddit.com/r/ExperiencedDevs/comments/noa841/sup...

I guess there will be more on their way.
Agreed. I did this journey twice. It was all static types when I was in high school and early college. Then I thought I was too smart to need the computer to do all that type checking for me ("I know what my program does, I don't need a compiler's help!") later in college and early in my career. Then I got incredibly sick and tired of working on really big projects in dynamic languages lacking the ergonomics of good static analysis.
Buy expensive knife? Or I could buy 15 cheap ones and just replace them as I go... And it's not like those cheap ones can be sharpened if needed.
I have a suspicion on how they're doing it. Every time this has happened there was a tv around.

1. Use smart TVs to listen for ad relevant keywords.
2. TV manufacturers sell the data to FB.
3. FB gets keywords & geolocation data, combines it with it's won data and voila. You know these 2 FB users where near this place and dog stuff was discussed.

Pretty safe and distanced from a scandal and yet very effective.
Now you are cooking with gas!

There are all kinds of 'browser extension' and most of them consume space, bandwidth, and cpu to no end. The one that would matter is the one that unifies both desktop and mobile browsers but it is not allowed by the browser makers because they don't want your data to be portable.
The shipping timelines from Amazon have become increasingly unreliable and non transparent. If it’s going to take a little longer that’s fine if I know about it ahead of time, but about 10% of my orders get unanticipa mid ship time delays now.
Why are creating an artificial either/or straw man situation and arguing it so vehemently?
I'm not sure that's the rational Delta would have. "We'll give you leniency because you punched our competitor's flight attendant."

If we wanted such private bans to be rehabilitative then private companies should not be allowed to impose life-time bans.
What if you look at a proof of stake coin, where the business is generating profit. And the business buys back coins to bring profit to owners.
Also considering staking.
Crypto is not all bitcoin copies, it is an evolving concept.
The paper is linked at the bottom of the article: Deep physical neural networks enabled by a backpropagation algorithm for arbitrary physical systems -- https://arxiv.org/abs/2104.13386

> physics-aware training (PAT)... allows us to efficiently and accurately execute the backpropagation algorithm on any sequence of physical input-output transformations, directly in situ.
At the same time, there is other stuff that is good quality but that could never be produced today because of liability concerns, but if you're in a home without small children running around you're probably good.

I'm the proud owner of a La Peppina espresso machine (image: https://www.home-barista.com/levers/my-first-lever-la-peppin...). It makes great espresso, but it also keeps a kettle of boiling water suspended on a relatively small pedestal where you push down on the lever next to it. I'm glad I own one because something like it will never be produced again.
It seems that the most common response to arguments in favour of a lab leak is always to attack the messenger. First "It's Trump so don't listen to him", then "Nicholas Wade is a racist so don't read him" and now "Ariel Fernandez is only writing a letter and someone anonymously complained about one of his papers once but they were never told what the complaint was actually about and the generic expressions of concerns never went anywhere". That's weak sauce.

I think most of us don't care who he is, only whether what they say is true. The claims in this article aren't actually new anyway, it was all covered in Wade's article already. So if it's wrong, let's hear why. That would certainly be interesting.
Well, I lived my entire 20s like that. Moved to Russia, lived in a Soviet era dorm, travelled to Vladivostok in a 4th class carriage etc. So it’s not theoretical…
Microsoft Zero Defects Memo
"I'm more interested in the motivations of the U.S. military for releasing footage that appears to be so easily debunked."

It makes plenty of sense that they would release these easily debunked videos. One, likely, reason is they dont think there's anything special about them. The second would be to cover up more convincing evidence by making people think they handed over all the videos.
Moderna Warns New Waves of Covid-19 Are Coming
I mean not even the next despot; the people in charge today love to have access to this (and they do).
Declined over the decades? Decades?
I feel like the comments are fixated on a particular number. It's true, $30/hour is insultingly low for a software engineer. But, it's a data point. That's your current value, because that's what someone is willing to pay. You can say "yes" and start getting $30 every hour, right now. Writing this HN post, $0/hour. Reading this HN post, $0/hour. Saying yes to that offer, $30/hour! Regardless of whether you accept, you can interview at other places, and use that guaranteed price as an anchoring point. You can probably get $40/hour from someone else, and now that guaranteed price has gone up. You don't really have to negotiate because there's a forgone conclusion. Company A that pays you $30/hour can be told "company B offered $40/hour". They can match or you can walk -- you're guaranteed that $40/hour no matter what.

You're not really in power if you can't walk away from the negotiation with what you want. All these power plays to set the first number, or to talk about your value to the company, etc. don't have an inevitable conclusion. They could end with "that was a really moving speech and you're absolutely right that we should pay you $200/hour, welcome aboard", but most of the time they end with "great speech, anyway $30/hour is our final offer". If you don't have the option to say no and go make what you think you're worth, they win.

Finally, if you're really 10x more valuable than any other employee at the company you're interviewing at, you can probably just put them out of business in 6 months. I never hear of this happening, so maybe we're all not quite as great as we think we are.