skysight-inc/HackerNews huggingface dataset:
Furin cleavage sites have evolved and are present in multiple coronaviruses:

- HCoV-OC43 (infects humans)

- HCoV-HKU1 (infects humans)

- MHV-A59

- ChRCoV-HKU24

- BtCoV-ENT

- BtNeCoV-PML-PHE1

- BtCoV-HKU4

- BtCoV-HKU5

- MERS-CoV

- BtHpCoV-Zhejiang2013

- SARS-CoV-2

Phylogenetic analysis suggests that it has evolved independently at least 6 times that we know of.

https://www.sciencedirect.com/science/article/pii/S187350612...

After that article was published a team in Thailand found furin cleavage sites in sarbecoviruses closely related to SARS-CoV-2 called RacCS203 (91.5% similarity to SARS-CoV-2) and RmYN02 (93.3% similarity to SARS-CoV-2)

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7873279/

Furin cleavage sites are common, nature understands how to utilize that trick very well, and continuously has re-discovered it.
Author here. I need to push back on this. This whole post is tongue in cheek, totally over-the-top and my way of doing things. I thought that was obvious including a lofty claim of an average consumer. People seem to be hung up on that. No one is calling you an idiot - and no, I have no romance for US military. Bought plenty of things from Swedish, Canadian and Swiss military and other industries. You’re unnecessarily painting a character picture that’s going with your biases, borderline politicizing it with gun ownership - I’d like you to think about this and reconsider how you judge people.

For what it’s worth - I’ve also bought overkill items and they’ve turned out to be a disaster. For instance, for the TPI fan in the example - I had to get an industrial fan controller because it was too damn loud and restaurant grade containers that are not BPA-free.
Yikes I totally missed that. Threads merged now. Thanks!
FB Sharing Debugger reports 3 "Warnings That Should Be Fixed" about its own URL.
It’s a pretty easy game. Sure you pass out once or twice learning how time works. If they made the game much easier, I think it’s just staring at a screen of grass.
99nusa.com
Yes, but I missed that it was being flagged because it was a dupe. Merging the threads now. Thanks!
There isn't a defined one. See my response to qubex and the email exchange w/ Stephen Worlfram copied in this thread.
We have a few of the Luxe 120's. I've evangelized these to my family who also picked them up. A bidet is such a life upgrade.
50 cent, I think, made the most of his money on purple Vitamin Water.
I think the problem with your last point is that while you, as a CTO whose job it is to know this, know the market salary, the person you're hiring probably does not. Like, I am more experienced than the OP, and my sense of what market salaries are in different places for different skillsets is incredibly hazy. So in light of this, it probably makes more sense for a candidate to, as a rule, push back even without specific knowledge of "$50,000 would be a fair salary" (to use your example), in case it's true. It would be a lot easier of course if there were more salary transparency, but employers don't want that.
today with a raspberry pi and a 1TB hard drive you can have a node and be one of the validators. If hardware is unattainable by the users interested in helping with decentralization (and there are few enough of those) large corporations or governments will be the only validators and defeat the purpose of decentralization
Same jobs as today.

Maybe just AI/ML would become less and less lucrative due to a huge glut of people graduating into it.
> a universal notary and authenticity service

Cryptocurrencies do not add anything to either beyond what was already done by cryptography.

> “bank accounts”

We already have bank accounts. In banks, hence the name. What’s the average transaction fee for the most popular cryptocurrency? By one of many metrics by which cryptocurrency fails even against the status quo.
Not for code tho. I've never seen booze help make good code
Unless you need to sync times. Such as with connected low power devices which need to wake up by themselves. (Like Mars devices running for more than a few years). You cannot wake them up via a ping. Device time is then unreliable, you need to sync with network time, and then distribute time changes to your measurements. But properly.

Google/Amazon do have a similar problem with eventually consistent databases, but low power (NB-IoT) meshes are harder, as synced wakeup's are critical. Don't rely on device time.
That's how Windows will behave but not actually how the underlying filesystem does.
Well, the bidet discourse isn't actually about hygiene, as you can see. It's a bad faith culture war discourse used to establish cultural superiority over other people. There's no point engaging with bad faith discourse and treating it as if it's in good faith.
While I agree with you on FB and Google. Fintech isn't just trading. Financial data is tracked and sold by these financial tech / services companies just like browsing activity. Even the "privacy first" companies like Plaid, who doesn't sell the data, would have given up their data to Visa had the acquisition gone through. All these companies are incentivized to track everything they can.
> You need to spend at least £600 to get a decent home espresso set up but it will get you something pretty close to good cafe grade coffee.

There are also the lever espresso makers like the Flair or Cafelat Robot, which are cheaper, more robust (no fancy heating elements), but also a bit more troublesome.
Hum. This is a nice shot, but I guess the affirmation is wrong. Lets think a little about geometry... I am not a new yorker, but by simply looking at google maps, at the lunch photo, they have the Central Park at their back, and the photographer has the Empire State behind him, so I guess he should be photographing the Hudson River or just posing for the photo.
Yeah, this is a very real problem, and I've experienced both sides of it as a customer and running an ecom biz. It's very difficult to spot some of these people ahead of time.

It makes me sad. Ebay two decades ago was a lot different. I never got burned back then, and did a fair bit of buying and selling snowboard gear, including boards that get up to around $800 each. There's absolutely no way I'd do that today. Just impossible not to get ripped off on it.
I can understand peoples' frustration with the artificial scarcity, but would like to see this same energy over the artificial scarcity of housing and free time. The oligopoly of national money systems is currently failing to provide people with basic access to capital. There's nothing intrinsic about cryptocurrency that will necessarily help this or exacerbate it, but the fact that I can get better interest on US dollars by depositing stablecoins on some defi platform, with no gatekeeping, is an indictment of conventional financial institutions more than it is of blockchain tech.
Sometimes the charge is faster than our break, and I have to move the car from the Supercharger stall before idle fees kick in. Annoying in a good way.
The recent article on medium by Don McNeil Jr came out, and seems to have broken the taboo around talking about this. I suspect that there is something out there not yet reported.

But at the face of it, it all breaks down to something simple - if a evolved smallpox virus emerged in Atlanta, is there anyone on the face of the planet that wouldn't believe it is a lab leak?

Lab leaks have a documented history of occurring, at least where that documentation is allowed to exist in the first place. Lab leaks have occurred where that documentation isn't allowed to exist (see USSR)

Yes, we have a coronavirus that appears to have emerged from the same city as the only BSL-4 in china, which also happens to be home of Shi Zhengli, who happens to have discovered the virus most related to SARS-COV2. Said lab was also doing "gain of function" research which was previously flagged as being dangerous on coronaviruses.

The only reason, at this point, that people are not assuming by default that this is a a lab leak, is because of the racism that some idiots engage in, Trump's actions (aforementioned idiot) and that the Chinese desperation to blame anyone but them.

The thing here is that China has spent so denying any access to WIV and than making insanely outlandish claims that they are now in a no-win situation. their stance required everyone to say "it's never creditable". Now that some say it is creditable, they either have to completely open their institutions and promote transparency (cancer for any authoritarian state) or keep access closed, and have this become if not the authoritative narrative, at least a dominate narrative.
It’s a suggestion. Generally, code complexity is created by someone that is actually pretty knowledgeable and competent. A straight confrontation won’t easily neutralize such a person in a discussion. They will know how to defend. If they also have peers they are close with, those friends will also negligently condone it with a simple ‘I don’t see anything wrong with that implementation’.

It’s a tough one, so I don’t even know where to begin other than an independent arbiter. Anyhow, I agree with you that it is a delicate matter from an emotional perspective (even though the underlying can be a reasonably objective matter).
Funny you mention that. Last year in Oregon a man stepped off the trail near a place called the Gorge while hiking too close to sunset, its is a huge wilderness north of the 26. People kept saying: dude, if you just went south you'd hit the freeway, but apparently he tried that and there were unscalable hills/cliff faces/vegetation for dozens of miles that when he followed them for a place to descend got him even more lost! Beyond me why someone would go off trail, or even start hike that late in the day!
Apple vs. (or plus) Adtech
Seems like "full disclosure" is a perfectly good way to say what they were trying to say. Your version is ok too, but does not have the same implication of "I have a particular bias here, so I am disclosing that so that you read my comment through that lens".
OP commented above.
This paper is terribly researched, none of the citations ultimately lead to references that support the claims.

There is no evidence that the Obama administration funded GoF research at WIV. They did fund research into swine-coronavirus in 2015, which is what the references actually say.

The author is relying on everyone to read the headlines, become easily impressed with technical terms like Chimeras and not bother checking references.
> If you click that it asks you what product. If you select a product that was returned you can't do anything further.

The chatbot has always given me an option along the lines of "I still have a question about this", which then connects me to a human. If that option weren't there, I'd simply choose another order so I could reach a human, and then explain the situation to the human.
Sometimes the lowest bidder is the lowest because they purposely underbid knowing they will have cost/schedule overruns later and the customer would rather throw good money after bad than start the process over with nothing to show. I like the second lowest bidder process mentioned elsewhere.
> Phabricator is the overall topic.

The topic is literally "Phacility is winding down, Phabricator no longer actively maintained".

> That's why the line you quoted had the word "camry" in it, in the part you cut out.

Doesn't really matter whether I cut it out or not. The original comment on the topic had as much relevance, context, or usefulness, as describing a car as a "cage on wheels": exactly zero.

And if you asked "What the hell is Camry?", and the answer was "a cage of wheels", that answer would still have no usefulness whatsoever. It would even be actively unuseful. Because this is a cage on wheels: https://images-na.ssl-images-amazon.com/images/I/81ra8W7ndGL..., and this is a Camry: https://www.motortrend.com/uploads/sites/5/2020/01/2020-Toyo...
That's a useful take,

Code says what is done. Docs says why
well, I said "one of" because the title tends to change hands over time.
That's funny, because I grew up making and consuming Japanese "chashu" and didn't learn that Chinese "char siu" was the same chop suey I'd seen and heard from old cartoons until recently.

Roast pork is a wonderful thing, and while I find a lot of commercial styles cloyingly sweet, the recipe is fairly simple in a convection oven or sous vide with a broil at the end.
IMO Google and Facebook have their hands remarkably clean relative to the rest of the Adtech industry.

I've heard some crazy shit about how much money comes from adtech to fund blackhat data brokers. Adtech buys hacked databases on underground markets, but more than that they fund supply chain attacks to get highly intrusive adware into popular apps. They frequently buy up applications that have a wide install base on phones and browser extensions, and then on the next update, request maximum privileges and use it to loot as much as they can from user systems.

It's a symbiotic relationship. Shady ad networks are often used by criminals for narrowly targeted attacks (advertise this crafted phishing site to women aged 25-35 in the greater Dallas Fort Worth area who are recently married). Those criminals use that access to obtain more private data which they sell to adtech companies. It's a pretty gross business.

In other news, HFT isn't bad because it's HFT, it's bad because order matching services have a bunch of shady, undocumented order types that are designed to allow HFT firms to specifically extract winnings from retail investors. They are absolutely economic parasites, and no one has any incentive to stop them.

https://www.amazon.com/Flash-Boys-Wall-Street-Revolt/dp/0393...

https://www.amazon.com/Dark-Pools-Machine-Traders-Rigging/dp...
New respect for steeple jacks!
They’re certainly not above it, but constant recording would destroy battery life and get noticed quickly.
Why the FBI Kept a 1,400-Page File on Einstein
Why would you pump gas in a Tesla?
I think it’s ok. That quote describes me too. There are lots of things to be interested in and excited by in life, computers are only a very very small thing. So don’t be saddened.

For me it’s almost like a graduation or transcending, getting so worked up about the details of computer shit just seems so silly nowadays. It’s actually quite dry and dull when you get down to it. There is a lot more to life.
I don't think there's necessarily a problem with trying things on a hunch, some of the best results in science have been due to a hunch or even an accident. The problem comes from trying a dozen hunches and only writing up one, or like you say completely cherry picking hyperparameters.
Appreciate the unflagging. Sending 0.2 BTC now as agreed
They're not and that's why I never go No. 2 in public. I cannot imagine just wiping a few times and pulling my pants up.
DDGing his name and institute gets me here: http://www.arielfernandez.net/daruma-institute2.html

Yeah, I can't tell if the biology paper is credible or not, but I smell crap when reading that institute's program. I think whether Covid is lab-engineered or natural doesn't affect me that drastically, the reality has been what this last year and more has been. My interest in the virus' origin is mainly in the popcorn-worthy political drama.

But after reading that institute blurb I'll just set aside the popcorn because this work doesn't seem to be the smoking gun that will set off popcorn-worthy political consequences. Unless someone else who I judge more credible endorses that letter to the editor...
Not really. Doesn't matter if the TV breaks in the store's front or back parking lot, it's still the store's parking lot.
The reliability of public debt forecasts
Seems lobsided. Sure Bitcoin suffers from high fees, but it serves well as a savings account. We've also started accepting litecoin payments on our site: I set it up once, and forgot about it. With Paypal it's a never-ending rigamarole.

I've recently closed my bank account, and started using something a bit more up-to-date (Revolut). I believe Bitcoin is the single biggest innovation driver in the tech sector right now.. but sure.. it's a scam.
Ask HN: How to evaluate a startups job offer with stock options component?
I have been offered a job by a startup that recently raised a decent amount of money. Let’s assume I have been offered 10k stock options worth $x with a cliff period of n years and vesting period of m years. I can exercise my options upto y years after I leave the startup.

1. How is it decided that 10k stock options are worth $x?

2. Since it’s a start up the stock options are essentially of no value, correct? I don’t understand how these options have any value atm.

3. What does it mean when they say I can exercise the options upto y years after leaving the company?
RFC.fyi: Browse RFCs by keywords, id or collection
Isn't BAME the euro equivalent?
I'd make a guess that it's the non trivial plot, outstanding performance and top notch actors that make Bond such a successful franchise.
Because that's a word that leads one towards assuming it was a lab leak. RaTG13 and SARS-CoV-2 are different all over their genome. They differ considerably in their spike protein because RaTG13 doesn't bind to ACE2 while SARS-CoV-2 and the pangolin coronavirus they reference do bind to ACE2 so they're more similar there. Evolutionary pressures are sufficient to explain the differences, you don't need human gene splicing. And the differences across the genome are decades different. The word "chimera" is being thrown out there to manipulate you into believing their conclusions, they don't really support it at all.
Bitcoin didn’t regress, what actually happened is that its fundamental flaws ended up eventually dominating whatever early enthusiasm allowed them to be ignored. It was never going to work, for a variety of reasons that were incredibly apparent at the time.

“Why did it regress” is much less interesting than “why did anyone ever fall for this?”
How the ‘Culture War’ Could Break Democracy
> and a few weeks later you get a bill from the logistics company for 10x the import duties to pay back the principal of the "loan" + a "convenience fee".

So mail the bill back with a (obviously-)form letter to the effect of "I did not agree to pay this, whoever told you I would has defrauded you, feel free to send me a letter at this address if you want me to testify against them in court."?

> the "recipient pays" logistical arrangement is intended for businesses,

> It's supposed to be something that they buyer requests the seller to use, for their sake; not something the seller uses unilaterally. So you actually have to register as a shipper business-account to get access to the UX where you can declare that your company wants to pay import duties in advance.

Sounds like evidence/precedent that they're using this mechanism intentionally fraudulently, rather than out of a mistaken belief that you'd actually want that.
Retail arbitrage.
> I'm pretty sure it's nothing but a pyramid scheme, but I always gave the enthusiasts the benefit of the doubt.

So go find out? I’m quoting you here for the “pretty sure” part. Do a deep dive. I’be done deep dives on Bitcoin, Ethereum, Cardano, Monero, Nano, Iota, Hyperledger, BSC, Uniswap, Tether, Chainlink and cursory glances at dozens of other coins/tokens.

I’m a tech guy. I work on an operating system/embedded systems. Nothing about blockchains, DLTs, crypto, at its core is a scam to me. The author saying the “silent majority tech people” know its a scam is such nonsense to my experience. Every tech person I know thinks either A) its neat/super cool, or B) they don’t know anything about it besides memes.

Sure there are tons of misinformation, scams, and bullshit going on. That’s everywhere and is not special to crypto.
A brand new Leatherman multitool costs less than 100$. For that price you get a knife, a serrated blade, a pair of pliers/wire cutters and some other stuff that absolutely comes in handy in the real world. It's not as good for fixing to the end of a rifle and stabbing someone, but for every other real world situation it's better.
I recently watched this video of Maciej making the same points on CNBC. Not bad for TV.

https://www.youtube.com/watch?v=igOmWeHMunw
Of course Amazon needs to do better. But the point remains - to-good-to-be-true prices should always arouse suspicions, as they are a tell for scams.
It's pretty standard to simplify things for the US market isn't it? Hence the Philosophers stone becoming the Sourcers stone etc...
Fair enough, but this doesn't have much to do with the article.

I don't understand why it's the top comment.
Kennedy's kids, yes. His parents, maybe. His aunts, uncles, and cousins?

Petrov is indeed a notable hero — but note that his self-interest was aligned with our collective survival in the same way Khrushchev's had been.
Business, education, research, and defence users were finding 3 Mbps coax revolutionary for decades before LAN parties were a thing.

Internet and Ethernet were useful immediately.

https://www.hpe.com/us/en/insights/articles/the-birth-and-ri...
>> Qualities of a good manager share a lot of qualities of a good engineer.

OK, you're drunk.
I’ve worked in procurement and let me tell you - there is a lot more than looking at a ranked list of bidders and going “oh look, lowest bidder. Job done, let’s go with these folks.” The caricature on HN is so incredibly misleading. Supplier selection is quite involved.

The right term is “optimal”.
Without getting into the specific issue of Bitcoin, I’m absolutely uninterested in calls to “speak out about” something because I work with computers. No.

We do not share a politics because we both know python or whatever. Leave me alone.
Cryptocurrency is like some sort of economic viral weapon.

It presents itself as a techno-utopian vision of freedom, takes advantage of greed to replicate itself throughout the financial system, and mutates to use as much energy and as many resources as possible.

If it were designed for that purpose, it would be the most cynical indictment of capitalism conceived.
Think "Pizza Hut", "Radio Shack", etc.
Mao "thanked" Japan for invading China because CCP would not have came to power otherwise. US ambiguous support of ROC/TW since during and post war is prolonging the ongoing civil war which PRC have tried multiple times to end post war. So no, generally US "support" / intervention has been been active pernicious to PRC interests.
> I believe Bitcoin is the single biggest innovation driver in the tech sector right now

Not gonna lie, I laughed at this.
The code as it stands is of course really dumb, but I think you can just pass `None` to each of those and have boto3 use the standard credential precedence.

On top of that they have mutable keyword arguments and generally quite terrible code: no exceptions thrown, just logging.error(), `if len(x)` rather than `if x`, etc etc.
I do feel their frustration. For many this has been on their mind for over a year now, and science and media painted them as racist conspiracy theorists.

I am not sure about HN. But on everywhere else on the internet right now, this issue is still incredibly astro-turfed. And it has not ended yet! We will see the frozen-food theory or "It came from Italy" disinformation espoused soon, by prominent scientists, repeated in the media. The tooth ache is just beginning.

https://www.propublica.org/article/leaked-documents-show-how...

https://www.straitstimes.com/asia/east-asia/taiwan-accuses-c...

https://www.foxnews.com/world/china-used-internet-troll-army...

But maybe HN is unique? One thing to control a narrative you can't control, is to have a post flagged. I am getting sleepy. Is it safe yet?
It's not. It's an economy. If you haven't engaged with the technology or even have a surface level understanding of traditional financial tooling like derivatives, options, futures, precious metals trading, etc. then you shouldn't parrot what someone on Twitter says. Take the time to understand the existing system and how smart contracts work and some of the blue chip protocols like https://aave.com/ or https://chain.link/ and then make an informed opinion.