skysight-inc/HackerNews huggingface dataset:
Like a lot of psychoactive substances, caffeine evolved as a pesticide in plants. Those plants tend to also evolve a lot of other compounds that modulate the effect of the pesticide. (I would guess there's probably some probabilistic/natural selection reasons for why this tends to happen.) That's why cannabis plants contain way more psychoactive molecules than just THC, for example, and why the experience of taking pure THC generally feels different from consuming cannabis.

Monoamine oxidase (MAO) is an enzyme that helps break down certain neurotransmitters (monoanimes, such as dopamine, serotonin, and norepinephrine). Monoamine oxidase inhibitors (MAOI) inhibit the activity of MAO, which can lead to less breakdown of those neurotransmitters, and so a higher neurotransmitter concentration.

This can have a synergistic and potentiating (or, if you're an insect, an additionally poisonous) effect for certain substances like caffeine. A certain amount of caffeine consumed along with MAOIs found in the coffee plant (e.g. from drinking coffee) could lead to more dopamine and norepinephrine concentration than the same amount of caffeine alone, for example.

This is also why it can be very dangerous to combine MAOIs with certain other substances. For example, combining it with tryptophan can lead to potentially fatal serotonin syndrome.

Coffee plants also contain much more than just caffeine and MAOIs. For example, theobromine, which is also found in chocolate (and which is responsible for harming or killing dogs if they consume chocolate).

I think this is the case for most psychoactive plants that people consume. You're typically getting a complex cocktail of many different molecules which all may have mutually modulating effects. This is why different coffee and cannabis strains can potentially cause somewhat different subjective experiences; they have different ratios of all the different compounds.
Yes. It is pretty ordinary. Given that the Dakotas neighbor Minnesota, it would not be unusual for an out of state engineer to have a license in a neighboring state. Indeed it is ordinary for professionals to have licenses in many states because clients often have work in many states.

In addition the motivation for the complaint, is different from the motivation of the license board. The license board almost certainly treating the case the same way it treats other cases. If it were not, StrongTowns would have sound procedural grounds for challenging the board.

There is nothing unusual here. The First Amendment suit will almost certainly be thrown out.
There does not appear to be any supporting case law. And lots of precedent against it.
People generally dislike change. I don’t think it’s about _lua_, anything new would receive the same treatment.
I think the main takeaway here is government, as usual, thinking short term and spending more money on bandaid solutions.

Yes, the $2600 gets you services, meals, sanitation and staffing. But in reality, you can get a decent 1BR apartment for $1500 that is waaay bigger than a tent, sanitation for free since it is an apartment, and have almost $1000 for groceries left over. And, you can fit more people in the apartment than a 12x12 tent. I know that this calculation is an over simplification of costs, but it still gives you a decent perspective on what can be done with that kind of money.

And I disagree this will save money long term or elsewhere. When you don't address the root cause and spend money wisely, you only leave room for more spending in the future.
What robots can and can’t do for the old and lonely
Allow me to give a counterpoint to the feedback on your book. It’s not the type of book I’d read, but the cover actually looks cool / interesting / professional to me. The first chapter was moderately engaging, much more so than what I’d expect from an amateur writer or college student. I can see why some people might feel it’s simplistic, but it doesn’t feel objectively “bad” to me.

I’m surprised and inspired you were able to write two books in two wildly different genres while being a SWE. Also surprised that did this while English isn’t your first language.

You’re putting yourself out there and being vulnerable in a lot of different ways, and I applaud you for that. Your work ethic isn’t unnoticed by me. I’d say please keep it up, I think you should continue writing and honing your craft. You’re off to a great start!
If anyone has trouble with normal (not-obviously-broken) VR, I recommend Yoga for Building VR Tolerance. https://web.archive.org/web/20190813004505/http://elevr.com:... The research organization ran out of funding but IMO they had some groundbreaking stuff. Thank goodness for the Internet Archive at least.
> or three random unrelated women -- who he claims only ever had lovely, adoring exchanges with him -- decided to destroy his life for no apparent reason.

Seems he dated two of them? I guess we all know who ended the relationship now. (hint: not them!)
Functional Programming in Go with Generics
The problem with Academic collusion rings is that eventually the ring can hold such influence that all "major" research comes from the ring. As ring members benefit there is no reason for them to switch to an alternate system. If one wants to progress in their chosen field then there is no benefit to publishing in an unread source.
Yeah NPR is largely for wealthy college educated liberals, who largely gesture towards helping the homeless but have no substantial interest in doing so. NPR has had numerous articles that take the small business owner’s perspective over the worker, and other such things. They are in no way left-leaning.
Very sad to hear about this. The top theory conferences are much smaller. Reviewers are usually invited to participate by a committee member who has met them personally or at least knows their body of work. If a low-quality paper was accepted, many people would notice. There are downsides, but the upside is that these kinds of collusion tactics wouldn't have a chance.
I made a Chrome extension a few weekends ago for this purpose:

https://chrome.google.com/webstore/detail/sitesearchreddit/p...

It appends "site:reddit.com" to the entered query in a new tab. Purely an invention of laziness -- but it's been a great QoL upgrade for myself and a handful of friends.
You can find echoes of your hypothetical in the laments of those who firmly believe that Trump's response was both inadequate and authoritarian/racist. There is no winning.
I learned that you could pipe anything to any device. Decided thirteen-year-old me was an avant-garde artist who would pipe my hard-drive to my speakers and create beautiful works. Was that just a `cat /dev/hda1 > /dev/snd` or something like that?

Incomprehensible shrieking. Later that year, someone posted about the thing that would become the Internet phenomenon called 'Anonymous'. I am certain that idea was birthed from the wailing portal of hell I summoned that day.
I use ctrl + u/d to scroll up and down half screen to get near where I want to go.
That makes zero sense. Of course accessing a GitHub remote with git means accessing a huge distributed system and involves "load balancer all the way to the backend services and data stores". If anything, that is the core of GitHub and the webui is bolted on.

It's baffling to me, what do people think happens when they pull/push from a GitHub repo?
I concur with trzeci that UltraEdit is by far the slowest in editing large text files compared to the other contenders being discussed here. I was not aware of CudaText before but just gave it a try also and it seems fairly rock solid compared to ST.
Trying to start showering and getting dressed every morning. WFH life has changed me...
Back in the day, over-sensitive ninnies were mocked in the movies and television. Everybody from SNL to movie blockbusters provided good comedy by poking fun at, well just about everybody.

Not today. Now you can't insult anyone without a woke mob coming to cancel you, wringing hands and wagging fingers on the same arm. The woke bullies are worse than ill-intented jokesters.

I can't wait for the pendulum to swing back the other way.
I understand the design might be quirky, but I'm not reading that.
Hrm, it says so right on the notice... did you RTFA?
Because the important thing about those fields is that they aren't really big endian at all, they're clearly ASCII characters. Why the spec you have decided to say they were big endian is beyond me.
You are only considering the cases where deviations from orthodoxy turned out to be correct. My guess would be that the vast majority of deviations have turned out to be wrong, like cold fusion, and we don't think about those because they haven't been turned into parables.
Basically the USA won't rest until the entire world becomes america. God forbid US corporations actually adapt to the countries they want to sell their products in. Better to leverage the US government's power in order to pressure other countries into adopting american laws.

For example, search the document for "right holder". It's full of this. Rights holders are concerned about this, rights holders are concerned about that... Why does some corporation's "concerns" matter at all? It's mind-boggling. This entire document is just an endless list of complaints from US corporations about countries that aren't playing by their rules. They want the US government to "fix" the other countries so they can turn a profit there.
You can still buy physical copies. BR are actually super cheap now that nobody buys them. I'd rather pay to truly own my movies.
I've melted a table once. Was testing a heat controller, and had the debugger left on.

When the laptop the debugger was running turned off, it also stopped the code from running on the microcontroller, leaving the heater on without adding any new controls.

It was a good learning to make sure there's a watch dog circuit, and that the microcontroller is much less trustworthy than the fpga
The life of the law has not been logic; it has been experience... The law embodies the story of a nation's development through many centuries, and it cannot be dealt with as if it contained only the axioms and corollaries of a book of mathematics. Oliver Wendell Holmes

https://en.m.wikiquote.org/wiki/Oliver_Wendell_Holmes_Jr.
Yeah, because we know republicans are definitely some sort of meritocratic organisation.
Predicted results are huge acceleration of global warming as albedo is decreased and water absorption of GHG is decreased due toreduced mixing. Plus some rather big local climate changes earlier than that.

Easily getting us to the edge of what is livable even with advanced technology.
tl;dr - too much modafinil.

Yes, I have Crohn's and I do not like to take the meds or listen to the doctors. This is NOT AT ALL SOMETHING I RECOMMEND, PLEASE DO NOT ATTEMPT IT.

Crohn's is an auto-immune disease and the main class of drugs that is used to treat Crohn's like mine (long term) are called TNF inhibitors or TNF blockers.

TNF alpha triggers the production of several immune system molecules, including interleukin-1 and interleukin-6. I realized I can track this with basic inflammatory marker test, I also realized that I could use diet to impact my markers. So instead of taking what is referred to as a Biologic e.g.: Adalimumab, Certolizumab etc... I started using NIO to try and get the same effect.

I got a pill making machine, and learned how to make supplements but they were not working well enough so I knew I needed something stronger. Then I found this article: https://pubmed.ncbi.nlm.nih.gov/32311496/ I think it was on HN but I do not remember for sure. I order some modafinil and worked it into my mixture.

I do not manually create my mixtures because I do not want to know which version I am on, I want my symptoms to go away and that should be the trigger to tell me if its working. So I have a 14 vile setup with an audrino all wired into my press and based on my food diary (e.g.: nutrient intake) it decides how much of what should go into a run. e.g.: how much burdok, tumeric, serrapeptase etc...

I got something wrong and ended up adding far too much to a run of pills, I didn't realize this until i started ti see floaters in my eye and I checked to see how much moda was left and it was far less than should have been left.

Then i did some reading and a side effect of taking too much moda can be detached retnas, since I have all the symptoms: Floaters, stars and peripheral flashes I am assuming that based on the timing I now have detached retnas, I also found my mistake and essentially no matter where my markers were I was getting about 600mg of moda per day. Which is far more than should be taken. This was for about a 1 month period.

I have fixed the issue now and I have a much more sophisticated pipeline but I will have to get this fixed.

NOTE: I am not a doctor, I have no college education or anything like that. I just like bio-hacking and decided to pursue my moonshot during the pandemic. I can explain more or provide pics and vids to explain further if you like, email in profile.

I am currently writing up a 100% independent non peer reviewed case study to document everything I have done and the results.
Why don't you believe either way? If the "he's creepy" side had provided their "curated receipts" would you believe them?

As it stands, he's provided receipts and the other side hasn't, so for me any reasonable person believes the person with the receipts.

And sure, we can't force people to form opinions in one way or another, but we absolutely can (and arguably should) criticize people who form their opinions in a way that is best modeled after a lynch mob, in the exact same way I would react to a... real life lynch mob.
"It's kind of like the big sites where you have to load the whole video before it'll start playing (no HTTP partials)."

It sounds like this is decribing the so-called "moov atom" begin placed at the end of the file.^1

1. https://www.adobe.com/devnet/video/articles/mp4_movie_atom.h...

If not, can anyone provide some examples of these "big sites". Would like to test.
> "while my own Dell XPS 15 can technically charge over USB-C, it needs 130W of power to charge and run at full bore simultaneously."

Meanwhile, my M1 MacBook Air can charge and run at full bore on a 20W iPhone charger!
I think it works like this: https://seuss.fandom.com/wiki/The_Sneetches

And if the mention of Seuss dredges up culture war nonsense, that's only fitting.
> the Church of the time was very into Scholasticism, Thomas Aquinas' fusion of Classical Greek philosophy (principally Aristotle's ideas) with the theological, moral and even epistemic and metaphysical teachings from the Bible. When the Catholic Church got upset at Galileo, they were upset that he was contradicting Aristotle, not the Old Testament.

I would be careful here to distinguish between Aristotelian philosophy from Aristotelian natural science. Scholasticism, especially Thomism, is still the preferred intellectual tradition and point of reference, and rightly so, but there is no refusal to entertain whatever valid insights may be found elsewhere. It is rather that many of Aristotle's scientific explanations have fallen out of favor and been superseded.
From Proteus, a Greek god of rivers and water known for changing his shape and nature to suite the situation. That description suites the Protomolecule.

https://en.wikipedia.org/wiki/Proteus
That sounds right. But then I'm having to compile all the packages I need, which makes it even much much slower than brew when binaries are available.
This is just excellent. Thank you.
I guess I always assumed that IRC was decentralized; one server could drop, or go rogue, with no ill effects.

But that's probably an anachronism, given the age of IRC.
Building more houses would help a lot in coastal California. Labor costs follow housing costs, so anything involving a local human being doing work is insanely overpriced.

If housing prices dropped, the labor market would stabilize, lowering the cost of more construction.

Instead, the planning commissions and zoning boards intentionally restrict the supply of housing, causing all sorts of market distortions.

Similarly, the transit system is repeatedly sabotaged. We spend a lot of money narrowing roads or intentionally lowering their rush hour throughput. Public transit is also systematically mismanaged. My theory is that they intentionally reduce practical commute distances to prop up housing values near the work.

(Sometimes they claim they make commuting worse to protect the environment. My car gets 50-66% as many miles per gallon in the bay area as it does in other cities. Even driving up a mountain is more fuel efficient than rush hour around here. It’s pretty clear the traffic engineering here is not concerned with CO2 emissions.)
I don't want to diminish the link above and it's efforts but how a first world society has to resort to stuff like this is just mind-boggling.

I'm an expat in a developing country and even for the poorest people a roof over their heads is affordable.

Everytime I go back to Australia or visit Europe I'm always shocked at the level of homelessness, it's just not right.

Why are dirt-poor countries able to house their citizens and the richest countries aren't? When will people see housing price appreciation far beyond wage inflation as a serious detriment to society?
Why wouldn’t you direct them to the author of the material in question?
> I also don't like lisp.

You don't like programming? That is precisely how that sounds.

Most programming languages in use today, one way or another, were influenced by Lisp.

If you seriously into programming, I suggest re-evaluating your point of view about it. Learning and understanding Lisp will make you a better programmer. I am not trying to sound like a patronizing dick. I honestly wish someone gave me that advice a long time ago. Who knows, maybe I would've become much more accomplished today.
Scott Adams's internet presence has evolved into something so incredibly self-absorbed and clueless about anyone else's feelings that quoting his facetious "apology" for the nebulous sins he has not yet committed, but expects to be pilloried for at any second, near the conclusion of this litany of denial, feels like a strong hint that the person quoting it is equally self-absorbed and clueless.

It's not as bad as if this dude used a vaguely-relevant quote from, say, a serial killer, or a general convicted of massive war crimes, but it sure does make me squint at his arguments a bit harder and wonder how much he's leaving out, intentionally or because he never noticed it in the first place.
No. OpenAI would not invest their operating capital in startups - that would be legally and fiscally irresponsible. Instead, a separate entity is created to manage the fund and OpenAI controls that entity. That fund then raises money from LPs specifically for investments. I would imagine some of the profits/carry will then flow back into the parent. What this ends up being though is mostly a branding exercise to boost OpenAI's developer ecosystem, with some upside for the company itself if they are able to fund some successful startups.
Speculation, by definition, lacks proof. Where would we be without speculation? Speculation has to range wider than proof for there to be any intellectual progress.

Galileo, whose name is invoked frequently in these discussions, speculated broadly and was often wrong.
I would mentioned the Duhem-Quine thesis here. The notion of a "critical experiment" is generally quite naive in the grand scheme of things. Parsimonious perhaps, but any falsifying experiment tests not merely the theory under consideration, but all human knowledge, as it were.
> Delayed Choice Quantum Eraser experiment

That paper is often misinterpreted. Its breathless conclusions don't look so special once you consider the experiment from the MWI perspective. Notably, they don't talk about the detection intensity much, even though it is quite important to the interpretation. Coincidence counters aren't white cards, and don't work the same! Yet, people interpret the paper as if the experiment would behave identically with an ordinary projector screen as the detector. It wouldn't, and that's the rub...

You too have been indoctrinated into the QM orthodoxy, and you've failed to realise that memorising catechisms might win you accolades with your peers, but doesn't necessarily help you understand the physical universe.

If you peel back modern QM, you'll find it is a very tall Jenga tower wobbling around in the wind, held up by more magical thinking that real science. The experiments it is based on have a very narrow scope, and those caveats and limitations are brushed aside by adherents.

People stating things like instant action at a distance despite special relativity being a thing for a century are just the same as a Christian priest ignoring geology and stating that God created the Earth in seven days. Self-contradictory notions such as the wave-particle duality are no different to the catholic concept of the holy trinity being one god. Giving up your devotion to rational thought is how you prove your devotion to the faith. The greater the nonsense, the stronger the proof of your willingness to be a team member.
But they could have just as easily said the integer value for "WAVE" was 0x45564157 in LE and been perfectly consistent.
May I recommend PinePhone Pine64 to you?

I notice you change the phone supplier, by the way. Would you agree that the characterization of mobile phone devices being a monopolistic market (in article title) is complete garbage?
(Chiming in as someone else with a PhD in astronomy.)

Eh... It's true that strictly following the rules of logic you can't disprove these ideas with an ad hominem. But as a researcher you only have so much time, and oftentimes the errors can be subtle. If a researcher has gotten a reputation for publishing a string of outlandish papers that fall apart under scrutiny, it's just not worth the time to go into them and figure out why exactly they're wrong.

One of the reasons this guy has gotten a reputation for himself is because he keeps publishing sensational results, uses his credentials to gin up media interest, the press picks it up, and then the rest of the community is forced to engage with the ideas to the outside world. The way it would ordinarily work is that he would submit his ideas to a journal, a few reviewers would spend the time finding all the holes in the ideas and either the paper would be published with the sensational claims toned down, or it would be rejected. In my view, the main point of peer review is to make sure that all the obvious problems in a paper have been fixed before it gets published so that most researchers don't waste their time trying to understand garbage. But he engages in a sort of end-run around the peer review process.
Why do you think most accusations are correct?
Many people are proposing "fixes" for this kind of behavior in the comments.

Fundamentally, there is no way to fix it, because the system is self-disregulating.

In other words, there is no mechanism to bring the academic system back to honesty over time; there is a mechanism to make it more dishonest over time.

This is inherent to government solutions. In modern times, democracy was supposed to be the regulating mechanism of the bureaucracy, but obviously isn't working. The bureaucracy itself certainly is disregulatory. Modern academia is simply an organ of the larger government bureaucracy.
Agreed. Hope when the time comes human societies have the spine to stand up for good.
Check this : https://pkgsrc.joyent.com/install-on-osx/