skysight-inc/HackerNews huggingface dataset:
From the Nature article:

"Peak antibody levels were 3.5 times higher in those who waited 12 weeks for their booster shot than were those in people who waited only 3 weeks. Peak T-cell response was lower in those with the extended interval. But this did not cause antibody levels to decline more quickly over the nine weeks after the booster shot."

I care less about short-term peak antibody response than longer-term T-cell response or longest-term immunizing antibody response. On the latter two points, this study was not encouraging or outright silent. Nor was there any indication of how well these folks fared after they returned to the wild.

This info doesn't seem sufficient to draw meaningful conclusions about longer term protection.
The hiding crypto from government entails im large part avoiding taxes, yet it seems like the government does not do much to recover lost taxes on current schemes such as fiscal paradises and so on. I doubt the governemnt would go as far as locating a harddrive, seizing it just for tax purposes. Something else must raise their flags for them to go that route. Also this route is very hit and miss in my oppinion and on a case by case basis
So how does cloudflare know to not trust your key? They know some secrets from the token manufacturers and test your response against them?

If so, what if the secrets get out? Then all the keys in those batches are poisoned?

Isn't this just some sort of side channel certificate authority?
Even the battery techs that show the most promising (in-lab, no guarantee of ever coming to fruitition) stats like lithium-air only have energy density roughly equal to or a bit lower than fossil fuels. Anything that actually blew that away by such huge would be worth billions if not trillions.
(This might not answer your question about people's social behavior.) I'm interested in Rust because it's a C-like language with similar use cases to C, with elaborate attention paid to making it easier to write correct programs and making it harder (sometimes impossible) to write large classes of bugs. It's giving a lot of programmers the experience of getting genuinely useful warnings and errors from the typechecker and other static analysis features in the compiler.

I'm not sufficiently proficient in Rust to fully appreciate these things yet, but it's also supposed to be nice for programming ergonomics and tooling.
The biggest problems with microservices are the lack of injecting cross-cutting concerns like security, monitoring, circuit breakers, resource metering, alerting, service dependencies, logs, resource isolation, upgrading on-the-fly, migrations, backups/restores of data, and configuration. These all have to be handled.

Docker with k8s is awful when it comes to resource metering. Docker is terrible with security and resource isolation. K8s, in general, is awful IMO because of the way it was architected and implemented.

Xen-ified "containers" (regular VMs but managed) with an ability to inject uniform, templated, configured concerns is how to do services: micro or macro; ephemeral app, infrastructure, or backend. Also, backups and logs have to live somewhere else.

Basically, a APPaaS/PaaS/IaaS in the spirit of K8s + OpenStack but much cleaner, workable, easier, simpler, fewer choices, more usable, more reliable, less stupid, and more standardized. (Discovery is insecure and fundamentally unworkable; top-down provisioning knows exactly what exists and is alive so use that as the authoritative single-source-of-truth.)

There is no other way I can see.
Ask HN: How do you promote a bootstrapped niche startup
I have a dashboard that i developed for a niche crypto market and have been able to get interest of 200-400 unique users who are retaining quite well as well. But how to do i go on beyond that? Beyond reaching out in their communities or advertising. Thanks for the insights!
Those that have been to a chinese grocery store in California know they sell all sorts of exotic delights that could cause a newcomer laugh, point, or say "ew" aloud.
Bleh, i'm 25, healthy, and more than all, lazy. But if it means I can take my mask off and be honest. I'm down.
Happy to help in general terms here.

Generally speaking, risk of audit and high fines and fees go up as the amounts you're dealing with go up. I don't know what kinds of values we're dealing with with 40-100 trades, so I'll just give you broad strokes. Having an accountant or a tax attorney review your numbers will, in almost all cases, cost you less than $1,000. If you're talking about $2,000 in income/gains, then obviously that's a non-starter and I'd just go the route you're considering (SaaS), having done good due diligence on the service as you seem to have. If, however, you're looking at $100k in OI or capital gains, I'd say a 1% investment to not owe all of your back taxes + potentially 100% or more in fines in 5-7 years when, potentially, you don't even have that money anymore.

As for your second question, I would just say there is no statute of limitations on undeclared income. The logic there is that you aren't incentivized to hide your income for 3 (or 7) years and then get off the hook, and it is difficult for the IRS or state taxing authorities to discover undeclared (as against under-declared) income -- i.e. how would they know about it? Thus, there is no amount of time that can pass such that you are truly free and clear.

You can file amended returns for ordinary income you failed to declare with Form 1040X: https://www.irs.gov/pub/irs-pdf/f1040x.pdf
This. Exit strategy all along. Or they were sloppy enough to get monitored accessing the coin wallet and exposing their private keys/passwords.
So it would make sense to split the roadmap into what already exists, and call that the feature list, and the rest can remain as the roadmap.

Then provide screenshots/code samples for each item in the feature list.

That sounds like a solution. Or just add some screenshots/code samples to what is already implemented in the roadmap.
Do you know how well it works if the speaker is on top of the bottle, pointed downward at the fluid?
Other than a solid majority of people being aware of and actively against such practices, I don't see it.
Having read a bit about it, my position is something like:

- Experiments are way too common and mostly have useless/unusable outcomes.

- Ethical standards are basically nonexistent.

- Limited animal testing for serious human conditions (cancer, disease, etc.) is justifiable if great care is taken to maximize the benefits and minimize animal suffering.
HTTPS is not required. t.ly works fine without "https://"
Employer wants as much done as possible ASAP. Physical & biological & social realities mean one person can be expected to produce 40 hours per week, 60 on occasion. There isn't an endless supply of quality knowledge workers, so (assuming the "80% movement" takes hold) filling that additional productivity expectation becomes difficult as businesses compete for a limited pool - more so as it's hard to fill a 20% gap when there's only "80%" or "100%" workers to fill it with (you don't get good knowledge workers part-time long-term).

Ergo (roughly speaking) you're asking employers to cut cumulative productivity 20%, and thus revenue/profits 20% for ... what? while other employers race forward with "100%" employees, producing 25% more per week.

40-50 hour weeks seems about the limit before employee productivity & availability ends. Claims of how productive ("refreshed! rested! alert!") employees are on shorter work weeks doesn't translate to comparable results, i.e.: 80% work time doesn't produce near 100%.

My personal goal is productivity. Give me more time at home, yes, I'll be productive there ... but I can be more productive via an employer (that's why I'm employed) than growing/building what I need on a farm. Cutting work hours means less work getting done, both for my own ends and my employer's bottom line.
Vaccine advocates like yourself can never explain why infection doesn't imply immunity while vaccines do.

Sinovac, the Chinese vaccine, is only 50% effective. Pfizer and Moderna are much more effective. J&J is somewhere in between. This is widely accepted but no one seems to ever ask: if I was sick a month ago, where does it fall in that scale?

The point of vaccines is to give your immune system a good enough idea of the pathogen, so that your body produces antibodies. Actually contracting the disease does the same thing, unsurprisingly.

So the question is how effective is natural infection of COVID-19 at preventing future infection? Surely it's better than Sinovac, a coin flip. No? Do you have any scholarship about this I can look at?
I could see 10 developers costing that much
This is likely very similar to how USDT works.

So the answer to your question is it would happen in crypto where there is no regulator and people trust ‘audits’ which verify nothing.
More or less spot on, but add a whole boat load of laziness to the equation.
Can confirm, building a Heroku of the future on top of Kubernetes.
> MacOS isn't something you should or need to manage swap for

I would 100% agree with you with regards to most macOS users. But as a software dev of course this is something you might have to do every once in a while.

The fact that you can't doesn't seem to align with the fact that macOS is the operating system of choice for software devs.
Opinions are my own.

There is something called the "gun test". The crypto on an encrypted hard drive is not more secure than the gold bars in a locked safe. Its security is a function of how the secret holder response to gun-on-their-head events. In this case, since the government is directly involved (and angry), a lot of criminals may pick personal safety over assets.

Frankly, I think a large portion of cryptocurrency proponents are overly confident in its "decentralization" and "safety". Cryptocurrency is only as safe as gold bars in a locked safe; and worse if you use a public exchange.
Photovoltaic panels would be really useful
> much easier and pretty much same result.

Actually better results even, because under macOS for example the webview is provided by Safari, but if you are using Chrome/Firefox as your browser of choice and you are using a Tauri app now you are using 2 browsers effectively, while if you ship a website you can use that website with whatever browser you prefer.
Which is going to be the future. The CEO of Moderna was talking about it. An annual shot that includes COVID, flu, cold and other vaccines. We'll get to a point in which we will look back at having a cold like you look at a Nokia 3310 now.

Edit: podcast link for who's curious https://ark-invest.com/podcast/understanding-mrna-conversati...
Now it's a browser that was probably already in memory for one reason or another, not necessarily a process per Tauri app.
You have a good point about the comma. I am not sure what the use of the word "funds" tells me. I think in the US, only the highly-educated or those in the financial industry would use that term instead of "money" (bitcoin?). It very well could be much more common in other parts of the, umm, anglosphere.
Linux users clearly have an echo chamber too.
Retool, but for Chrome Extensions
I’d love to annoy or perplex people by doing this. Unfortunately, her name never seems to come up in conversation.
Innovation Method Could Change the World
Let me share a quick story with you:

In 2017 I was a lowly assistant that regularly refused my friend's calls to start a company with them. That is until I met and was encouraged by a successful founder who was my boss at a side gig making flying machines ...

I fell in love with innovation. Over the past several years I grew one startup to 10 people and $thousands in sales before going bankrupt and homeless - learning the lesson to not be ideas-first. I tried again with a laboratory spin-off and followed Steve Blank's Lean Startup process to find a market need, getting a million in sales and an interview invite to YC, but we struggled to turn the qualitative insights from 100+ interviews into tangible deliverables or accelerating growth.

Then I discovered Tony Ulwick's "Outcome-Driven Innovation" (also known as "Jobs to be Done") process and something clicked: This methodology could, with high degree (86%) of certainty, determine exactly what "outcomes" the market wanted and thus which ideas can win. The root cause of low success rate in needs-first approaches was the lack of a common definition for what a "Customer Need" even is!

So for the last year I've been sharing Tony's methodology with others. But oftentimes, they're not interested. Even within my startup community it seems like everyone is far more keen to follow the more accepted but inferior "Fail Fast" and "Lean Startup" approaches, despite the far lower success rate.

Why is this? What can I do to help this method go viral and share what I've learned with the world?
Scala has a lot of 'sugar':

f(...) becomes f.apply(...)

matching calls unapply with some various binding.

Some parenthesis are optional: Some(1,2,3) is Some((1,2,3))

optional . so a + b is a.+(b)

colon changes associativity, so a +: b is b.+:(a)

for expressions become, map, flatMap, filter, withFilter and forEach, according to various rules.

def f[A: B]() adds an implicit parameter of type B[A]

I'm sure there's more but that's the top of my head. Of course it's not actually a long list, but none of that is obvious for a newcomer.
This guide is nicely written but uses jargon that people who haven’t been keeping up with client and server-side JavaScript frameworks won’t be familiar with, including “route,” “slug,” and “hydration,” not to mention “Svelte” and “SEO.”

It seems fine for its intended audience, but if they wanted to help out beginners who somehow stumbled onto this page, adding some outgoing links to definitions where these terms are introduced might be useful.
Manage micro-front ends applications with angular? Here's how
Maybe we'll finally start addressing real unearned privilege: genetic. Pro sports players didn't do anything to earn the genetic makeup which accounts for a significant portion of their ability, yet they aren't asked to acknowledge it and take steps to reduce its impact.
Counterexamples in Type Systems
Would you call tethering your Android phone via USB to your laptop a basic thing?
Recently, I was having trouble with my phone's WiFi hotspot and tried to tether via USB. The only solution was Horndis, a 3rd party kernel extension. I quickly became knowledgeable about kexts and csrutil, rebuilt a kernel extension for M1 architecture and gave up after several hours of frustration.
It's ridiculous that Apple can get away with being so closed
> we justify experimenting on a known serial killer if the experiment will save a million children's lives in the next 10 years?

Without hesitation. A serial killer is someone who believes murder is acceptable and turnabout is fair play. Provided they are actually guilty there is little that is unjustified when dealing with willfully violent actors such as that. Add in now this person who has harmed society can be used to repair it and I can't think of anything more fair in a cosmic sense.
> Everything in a CS curriculum is easily Google-able.

Not in my experience, it isn't. Maybe for the first two years of undergrad but after that I've found that Google rapidly becomes useless.
I pay more than 55% in effective tax rate, and my income is about 60k USD a year.

I live in Uruguay, South America - my taxes include healthcare and retirement.

It's definitely not ideal and it's crippling my chance of ever owning a home, but it does pay for a lot of social services way beyond what the U.S. provides - key differences being state provided healthcare and education up to and including the university level.
I'm not sure I understand your point. Rust has ADTs, like OCaml and F#, and Go doesn't. Rust can be written almost like OCaml and F#, Go can't.
I think we are at the tipping point where for many roles in many organizations a Bootcamp grad is no longer just an alternative pipeline to hire with some caveats but increasingly the better hire.

At a larger tech co I am consistently seeing boot campers coming in better prepared and with more hustle than CS grads. It would be interesting to see if their acceleration through the ranks is on average faster. It definitely is from my anecdotal experience.
brb submitting the "Diving Suppository" to YC
Mind sharing some background? I'm curious about how you snagged the domain, how you've managed to monetize it, and what the competition is like in this space.
This is why VSCode is adding Workspace Trust to prevent extensions from running untrusted code by merely opening a directory.
https://github.com/microsoft/vscode/issues/120251#issuecomme...
I just looked it up because I wasn't sure how old it was...

...and damn. IE6 was released in 2001, and the last update was 2008.

By 2012, IE9 was the norm, and IE 10 came out late in the year. That's also around the time that Chrome started gaining significant market share.
AmigaOS 3.2 for all Classic Amigas released
Like Electron, with Tauri you write your GUIs with HTML, CSS, and Javascript. Electron uses Node for the client-side non-GUI functionality, while Tauri instead uses Rust binaries to accomplish same. That's the alternative part. Node is not needed at all in the final build, although it may be used to create your app before bundling for release.
This reminds me of the excellent shareware game for the Mac called RoboWar [1] by David Harris. In it, you programmed a robot to destroy other programmed robots in an arena. You could spend points on different weapons, shields, and processor speed.

The programming language was a custom stack-based language like Forth. It worked quite well for its purpose, as you could easily count instructions.

1. https://en.wikipedia.org/wiki/RoboWar
Don’t know why you were downvoted; there’s a very similar part to this article in the book, except instead of pigs and mice, it’s dogs.

Other parts of that book mention machine-generated texts (with hilarious results). Almost 300 years later, it’s remarkable how relevant much of the lampooning of the sciences (broadly considered) in this book remains!
I know libgen has a desktop client, but it still downloads files from server. Would be nice if a libgen/scihub client can search and then download from torrents.
Unless you quantify the marginal energy cost of carrying additional fuel payload and recovering a component, convert it to an environmental impact quantity, and compare it to the environmental impact of marginal construction, you shouldn't make claims that sound correct in your head but are not backed up by anything. There's a tradeoff and we don't know which one has greater negative externalities. Not all cost of marginal production is allocated to energy and materials.
in particular, a linear change in antibody levels, which trigger an exponential response, doesn't really mean very much!
> For it to slow down within 200m, it needs to basically stop in 0.075 seconds

For non-aerodynamic fragments, this is not very difficult. Furthermore 0.075 seconds for a 200m braking distance seems too short unless you're flying at something like Mach 15. But you're not flying at Mach 15 if you're 200 m from a ground target because you can't fly at Mach 15 at a 0-200m altitude -- certainly not with something powered and guided and equipped with sensors. Maybe a solid metal rod could do that but this ain't it. So it seems quite reasonable to assume that 200 m off the target, the vehicle will be at a significantly slower speed, much like ICBM RVs don't impact their targets at Mach 25 either.
In general, you store the keys of your coins, not the coins themselves. Everything is inside the blockchain and the blockchain makes possibile to be sure that you have what you should have, thanks to consensus.
There was a lot of Russian collusion going into 2016, just not from the people you expect it.

For example, Fusion GPS paying Veselnitskaya, using her to lobby _against_ the magnitsky act, and also supplying the infamous "dossier" which was paid for by the DNC.

The whole thing is a cobweb or power players who use connections and ignorant US media to parrot back narratives, divide events into political tribes, and isolate people from the truth. It's a dumpster fire where people end up believing things that are untrue and they don't even know why.

https://www.washingtonexaminer.com/news/analysis-mueller-and...
This just seems like Mt. Gox 2.0 waiting to happen.
This tracks. Being transparent if you're audited will be key. You're trying to keep track of things, and trying to pay what you owe based on the information you have.

Just as a heads up for other folks reading this, having a basis of $0 isn't the same as paying tax on the mined value at ordinary income rates (cap gains rate differs from ordinary income rates). Mined coins and bought coins are treated differently owing to how they're acquired.
Is it ironic that I opened this in a tab?

I'd like a browser function that says "open a text file and save all the URLs"
I understand the difficulties of competing with incumbents because size and usage are not your strong points yet, sort of. You all have over 16k stars on GitHub as a proxy for interest! My team still has under 1k.

It also doesn't help that we chose a language that isn't popular. But you all need to think about how decision making like that massively effects adoption.

You won't learn these lessons quickly, they take years, so ignore people who say you need to experiment and research what works. The biggest issues you'll face is that no one will tell you what's wrong unless you're faced with it in threads like this on HN or other places where you'll meet consumers.

The worst part of it is, these are the obnoxious glaring details. There might be massive decisions you make that consumers can't pinpoint for you. Thought-leaders don't often describe those details because of survivorship bias.

What I can see this team failing at, too, is that you need an anchor client. You're spending all this time on BS that doesn't mean anything at all.

Specifically, at GitHub, they already had users using Atom, which made for a great way to advertise Electron. It was Atom!

You need to essentially find whales (Read: engineering leaders at businesses) and make the product good enough for one of them to say, yeah I'll use this over Electron, and if they're an attractive user, pump them on your front page. Find a way to make a deal with them so that you can funnel developers to their hiring channels.
Oh I'm not fighting my OS to get basic things done, also I can't remember the last time I used awk. I use grep often, but I'm okay with whatever version I have (apparently it's BSD grep 2.5.1).
A lifestyle change, switching to a vegetarian organic diet, can solve most of these issues regarding diet. The others, yes, are impossible to get around completely.
It is called an "attribute" and it is part of the language itself.

There is also #![]. The difference is what they apply to, #[] applies to the following thing, #![] applies to the parent thing. You'll see #![] to enable nightly features in Rust, for example, and #[] for things like custom derives.
"Intentional threats to national security" are not ipso facto terrorist acts, but they should be addressed with the same level of severity.
Here is their browser extension for "rethinking" tabs: https://www.skeema.com/ (currently invite + waitlist). Was really hoping for images of the actual, HCI-research-informed UI update, but alas.
Lol. I clicked this on my (managed) work laptop, and immediately got a Compliance warning popup. I don't know what I expected...
I anxiously await the next bear market crunch to flush out all the garbage that has gotten sucked in. It feels like 2017 all over again.
Sounds like the recommended way to read a research paper: (1) read the abstract; (2) if you're still interested, read the conclusion; (3) if you're still interested, read the body of the paper.
Who new the next-gen oxygen bars would be more akin to fecal transplants?