skysight-inc/HackerNews huggingface dataset:
Couple of things to throw out there:

1) If you are able to bring a major drug to market 3 months earlier, it's worth billions. Hence the continued interest in computational approaches.

2) Salaries in the pharma/biotech biz are set nationally. Yeah, there are variations by geography, but less than one would expect. Thus, a PhD with x years can look up the salary range per region, etc.

3) The data is confusing and the error range(s) are unknown. So, many/most of the models are retrospective rather than prospective and if the initial guess at the biological target or model fails, everything else is a waste of time. Google for all of the failures re: Alzheimers.

3b) As we can't test on humans (at least not ethically), we're totally dependent on animal models being good predictors of human behaviour. But, while chimps are like 98% similar to humans, the difference has resulted in catastrophic failures in Phase 1 testing. Diseases by the score have been cured in mice...

4) Computational modelling occurs at the start of the process, which is the most efficient. I think they had a sequence for the mRNA vaccine a few days after the Chinese published the data. Getting it made, stable and deliverable is where the time was consumed. And then the various clinical trials are significant costs in time and money. Hard to trust a model for a new class of disease or mechanism.

5) Computational methodology has been (over)sold since the 60's. Yeah, there have been successes but they've been way fewer than hoped and people have grown rather jaded when presented with the latest breakthrough. ML/AI isn't really new as it was studied in the 90's, but there's way more data. See (3) above.

6) The crystal doesn't always form. The reaction yields brown oil rather than white powder, or doesn't scale. Chemistry is messy. And there's a lot of material design problems that have not been amenable to modelling. There are new ways of gathering information (CryoEM), but we still need more/better.

7) We need newer software and better parameterization. Both of these trace back to academic work on Vaxen, maybe SGI's. Visualization software is probably the most valuable tool right now, with broad acceptance in the research stage.

7b) Physics might bite us in the ass. MD software, for example, tries to model explicit protein, ligand and solvent atoms/molecules. Even given revised software and parameterization, entropy or chaos might prevent accurate numbers or what we can calculate might not be pertinent.

I could go on (and on), but I wanted to leave you with an upside... If anybody DOES deliver the goods, they'll be bloody heroes. Fame, fortune, the whole gig - like CRISPR and the other advances that have occurred. So, if you and your buddies are smart and dedicated, it'll beat the snot out of selling ads on handhelds in terms of making a difference.
Russia has an amazing math education tradition. I always recommend Russian math books and Russian math programs. They are excellent.
botched ssl:not a good look
what's WhatsApp? is this a competitor for Signal? (jk).

I've got a few dozen non-US clients, they loved WhatsApp, after our first Zoom meetings they asked a few times for WhatsApp connect. I mentioned privacy and protecting our respective business interests by moving to Signal. they had near zero issues switching and hardly had any questions. as a tech professional, when we make a recommendation to others who trust us, they just follow. don't abuse the power, fight for the user.
I have a couple of old dusty laptops at work, that I think are just old enough to have 32bit uefi (or bios?) and cpu with 64bit support. Are there any current distros that should work, I wonder?

I suppose I could dig up an old Debian Iso-but I'd prefer something with a recent-ish kernel (wireguard) and a half-secure libssl and opensshd.

Hm, maybe openbsd (current) still has support?

Ed: I've been doing Linux installs since the 90s... Around kernel 1.3 or there abouts - but it's been a while since dipped my toes in 32bit/hybrid x86 systems. .
and intuitively think of circuits with no moving parts as reliable

Yes. It's counterintuitive to realise that non-mechanical parts are more prone to 'burn-out' rather than 'wear-out'.

I've only just got over my reluctance to entrust large volumes of data (6 TB) to SSDs rather than HDDs. But I'm still a bit twitchy about that. Time will tell whether or not my fears are justified.
Scientists have taught bees to smell the coronavirus in seconds
Yep, the "trustless for thee but none for thanks" model.

On the plus side the DAO hackers are doing very well for themselves economically, the old chain, Ethereum Classic, is having a moment [1].

[1] https://coinmarketcap.com/currencies/ethereum-classic/
This is why i am grateful our ass-hat of a prime minsiter has carbon taxes and overcommits us to "green" programs..

because if every one of the 32 million canadians reaced zero emissions, woudl the world even notice?

Look, i am all for "green" programs, but over-taxing us isnt the answer, our contribution is minimal.. we would be far better off helping others get off coal.
Somehow the article fails to even acknowledge the roles that commuting and non-affordable housing play in people not wanting to come back into the office. To me, "Office culture" is not worth spend 90 minutes each way crammed into a metal tube, tip-toeing around human feces and trying not to inhale the crystal meth on the Bart platform.
I suppose that this differs at how mathematically mature the student is. For undergrads and high school students it is, as you say, probably a good idea to give a lot of motivation and applied examples for the theory being taught. I suppose this article is more geared towards teaching university students, and then it can well be that examples and applications become more abstract. Of course, introductory topics such as Linear algebra and Calculus would lend themselves very well for a wide range of application examples. On the other hand, in more advanced and abstract university courses the 'realistic problems' should already be reasonably clear for the student when starting the course.
If this bothers you, dont use Chrome, ever. Use Chromium if you really need it and dont want to use Firefox. And get rid of your google account whilst youre at it.
You may be misunderstanding, though your username is very appropriate. :)

"Harmonics" here isn't referring to the harmonic complexity of songs.

It's referring to harmonics as in overtones, the complexity of the overtones -- the timbre.

It's the voice of the bird, not the songs it sings.
But you don't know everything that will come afterwards. You know what's planned.

The consent during cannot be valid. It's not informed: in fact it's specifically misled, and that is known to the other participant.
That's pretty neat, but a browser-based application just isn't the same thing.
The Play Store takes 30%, in addition to their own set of restrictions. Surely 30% must be a large motivator for some mainstream apps moving to another store - it just turns out few users on Android will go for that.
Music Demixing Challenge by Sony: 10k CHF cash prize pool
Fastmail has been really solid, I'm actually impressed! It supports multiple domains from one account, unlimited aliases, their calendar/mail app is good, their folders works really well.. I'm happy to have moved to it.
You misspelled "matrix"
Most people do. However, the precision of the Israeli system (Based IIUC on cell tower triangulation) was not good, meaning you'd have a nontrivial chance of getting randomly get flagged for 14 days quarantine (with legal consequences for not doing so); Some people were flagged multiple times within 3 months, and it's not entirely clear what the rate of FP was, but it was nontrivial.
Starlink will never replace 4G/5G in relatively-populated areas, because any RF wizardry they can do from orbit will work even better for talking to a tower at short range.
In app purchases from the Apple store are subject to the cut to Apple. Apple pay is separate and though the consumer does not pay the transaction cost (Like VISA/etc), Apple is still taking a cut.

> Apple currently takes a 30% commission from the total price of paid apps and in-app purchases from the App Store. For some small app makers, the new policy could cut the amount that they pay Apple in half.

https://www.cnbc.com/2020/11/18/apple-will-cut-app-store-fee...
There are a lot of comments in this thread discussing biotech salaries. They're not universally true. Source: I'm the VP of data science at Recursion, a biotech company focused on drug discovery, so I manage or have visibility into hiring in the domains that most people on this site would likely be interested in.

The biotech industry (which is made up of at least three rather different verticals: tools, diagnostics, and therapeutics) is changing quite a bit today. There are certainly companies that have less of a technology or data emphasis or who are still trying to figure out the value those could bring, and those companies are far less likely to pay well in SW/DS roles. There are others that either from their inception or more recently realize the value these approaches can deliver and compensate accordingly. I personally find the new wave of biotech startups that are focused on being hybrids of experimental and computational capabilities extremely exciting (which is why I'm at one) and these are the firms where software and mathematical skill sets are most likely to be valued.

You'll probably still make more on Wall Street than you would in biotech. But you don't have to be _badly_ paid in order to work on a meaningful mission. OP is, IMO, correct that biology is entering a phase in which computational skills are a rate-limiting factor in our ability to make advances (note: not _the_ limit -- experiment is still absolutely critical), and it's a super exciting and impactful field to be in.

Shameless plug: Recursion is hiring a TON of positions in data science and machine learning, engineering, and elsewhere. Check us out: https://www.recursion.com/careers. (Contact info is in my bio.)
Bringing someone like Alex Jones into a thread like that is exactly what is killing any intelligent discussion a out the subject?
Why? Imagine if every topic about lab grown near would be filled that *that's what Hitler wanted" - it is boring and tiring.
Not sure if it of any help but you can try my list https://ideasfilter.com
In my case, it generally just makes me want to read it more, to see what the fuss is about.
Not holding my breath there...
"Fake meat" is an epithet. It's a meat substitute made of real food. None of the ingredients are remotely dangerous. People have been eating tofu and seitan for centuries. We know very what the effects of vegetarianism and veganism are. Some nutrients like iron and B12 need to be looked after but otherwise you can have robust good health.
FB SDK is basically everywhere (including e.g. Google's Waze app), and the data is incredibly useful to FB to segment users.
It's the wording. There are no "risks" in not returning to the office other than whatever the leadership decides to inflict on them.
If I were an unscrupulous seller, I'd write a nice review myself, pay a stooge to post it, then pay a bunch of other stooges to mark it helpful repeatedly for the next six months from different IP addresses. I don't think it'd be all that hard but then again I've never tried it.
I think it's much easier if there is a teacher involved in that process. The best possible teacher would be a personal tutor who understands your needs and works with you. The next best would be a teacher in front of a class who gives specific assignments to each student based on their own talents. Unfortunately none of that is on offer in the U.S. public educational system, where the quality of the teachers is quite poor and the education is standardized to a lowest common denominator, with substantial time spent on standardized testing, and a reluctance to remove disruptive students or poor performers from the classroom.

Even recommending which books to read -- a very personalized topic -- is something a good tutor can do.
> It's not unprecedented. The adoption of systemd was forced on distros through political pressure, and not for technical reasons.

Sorry, I'm going to slag on this.

Anyone could have put in the work to make a better init experience. No one put in that work.

System Management Facility (SMF) existed on Solaris since 2005 (systemd didn't appear until 2011?). launchd on OS X dates to a similar time. Someone could have copied them--no one did.

Even once it became clear that systemd was going through, still nobody could muster the work to put together a viable alternative.

Where's the "meritocracy through code" Linux mantra in all of this?

You can say what you want about Poettering, but he put in the work to write the code. Nobody else did.

Perhaps the problem is that an init system is a metric boatload of finicky code that nobody had the guts or skills to drive to completion?

And for the old-init bigots, sorry, that wasn't working in spite of what you claim. The fact that Windows, OS X, Solaris, etc. (and then systemd) all converged on essentially the same design is because of common needs on modern computers.
Ripple didn't exist when XRP was created.
ripplepay now rumplepay.com was probably what you meant.
> well it's happening in incognito mode too.

You're raising doubts regarding a browser's threat to privacy by stating an observation that depends on blind faith on the same browser not threatening privacy.
Do Jewish parents "save their children" from history lessons and postpone them?

When is the holocaust and other info about historic anti-semitism introduced?

I would be surprised to hear that they delay this, I believe some of these historical stories/events are part of their religious studies as children.

Giving the oppressive system a pass for X number of years and letting children walk through society ignorant of the threats they face is an even bigger disservice that any demoralization that may or may not occur in my opinion.

Black children literally get murdered by the state for benign activity, I think by 13 (the age Tamir Rice was murdered) they are old enough to start learning why.
Yup. If openzfs was gpl-ed tomorrow morning, btrfs would be dead by tomorrow at lunch time.
Seems implausible that they can perpetually run at a deficit. Unless you mean absent subsidies. But if such subsidies exist then that is one way to convert the losses into profits.
> Bash is great, but when it comes to writing scripts, people usually choose a more convenient programming language. JavaScript is a perfect choice

Awaiting citations on usually, convenient, and perfect.

> await $`cat package.json | grep name`

I mean, in the first line they're well into "I don't understand shells" territory with a superfluous cat pipe (you can just grep name package.json). This is seriously published under the google banner?
The sticky part is the social network effect. Its by FAR the dominant messaging app in much/most of Europe. Some switch to Signal/others has occurred... but if you have _one_ friend who doesn't switch that you want to continue to communicate with... you're stuck too.

Not to mention, the alternatives aren't great. I'm sure others will provide a better breakdown, but at a high level:

- Signal is the best alternative but missing features like crazy that really do matter to "normal" people (can't change your phone number! Stickers only can be added from the desktop app)

- Telegram a) has a poor reputation in my greater social circle b) doesn't actually encrypt by default

- Matrix is simply not accessible to anyone who isn't highly computer literate
<details> is a native HTML accordion
Since when is being brought in for questioning equivalent to being arrested anywhere? Being arrested and prosecuted is being arrested. People deliberately conflate it build narrative of PRC hiding covid origins when its generic rumor quashing behavior by PSB. Point remains, non of the doctors alleged to be part of some massive cover up by conspiracy peddlers were subject to any of the treatment PRC actually reserves for coverups.

Huang Yan Ling stopped working at WIV in 2015. The only reason she's noteworthy is conspiracy theorist tried to link her as patient 0. People have some expectation that PRC should indulge in random conspiracy theory by parading her around. Like is US going open up fort Detrick for scrutiny? No because entertaining the whims of yahoos is ridiculous.
What exactly do you need a citation for? The starlink antenna is a $499, and the subscription is $99 a month. That's extremely expensive for internet, I'd only consider this if there was literally nothing else available. So yes, it will be bought by wealthy people who live out in the sticks, because if you're not from a wealthy nation and quite comfortable financially yourself, then $99/month is crazy high. I guess communities in poorer countries might pool together and buy one antenna+subscription to share between themselves, but that cannot be the main market for this service.
I don't own any. The only reason why I bother complaining is that I respect that Apple aren't like Google or even microsoft both in terms of tracking and taste, but then they are extremely closed which spoils what I think would be the perfect laptop.
Uhh... if you define reputable by market cap and purported volume then... [1]

[1] https://ag.ny.gov/sites/default/files/2021.02.17_-_settlemen...
A Future with Fewer Banks
It's not that much of an advantage.

The most powerful, highest range stealth plane in existance is already Chinese.

The biggest factors in aircraft range and kinematic performance nowadays is doctrine. The US decided vertical landing is more important than range in performance.
Do you happen to know what the early bootloading situation was?

I'm familiar with ISOLINUX[1] (a very small bootloader for iso9660 cd roms) and SYSLINUX (for bootloading floppies (from which isolinux is derived, i believe?)). Was this a key enabling technology? Were other bootloading solutions ever used?

[1] https://wiki.syslinux.org/wiki/index.php?title=ISOLINUX
Having a mostly statically linked executable handle this rather than some bastard child of virtual environments and docker images is a dream come true.
The digital currencies that matter
Dogs can synthesize vitamin C and we can't.
Yes standards useful and workplaces can easily enforce their own internal ones for things like line length limits. But they are useless if they do not work for everyone who they apply to and especially not if they don't adapt to world around them. Cubit used to be a standard, too! But then we developed better ways to measure things than our inconsistently sized forearms.
There's also the Big Bad consulting trope which has it all backwards.

Client states they need something like Y, consultants assess the situation, understand they should do X but keeps it to themselves, the parties come to an agreement to solve Y and do so. Client states they need something like X..
I used to go to a Goodwill frequently, both as a destination for exercise walks, and for the fun of treasure hunting (especially silver). Four random bits:

* Most expensive trip ever, and maybe why I stopped going... I was skimming the titles of the PS3 games in the display case near checkout, and this worker walks over, just to pointedly cough on me, then walks back to checkout. I was incredulous, rather than angry. It turned what I picked up at Goodwill was the worst cold/flu I've ever had, taking months to blow many lifetimes of snot. What's the opposite of "goodwill".

* Second most expensive trip (better kind), I found a Roomba 400, for maybe $20. So then I had to play with it, and acquire more expensive Roombas to play with. https://www.neilvandyke.org/racket/roomba/

* One time, as I was walking into Goodwill, this guy passed me, going the other way. My immediate thoughts were something like, "he wants to get out of here, very expressive eyes, striking hat, and features, he should be in movies". It took additional brain cycles before I registered him as actor John Malkovich.

* I never did find any silver at Goodwill. I've heard that they have staff sort out some things at a central facility, before it's distributed to stores, and that some professional flippers get access to shop at that facility. (On one walk, around then, I did find a set of silver place settings at a yard sale, but the seller didn't know it was silver, so I told them. I said I was walking up the street, to get a coffee, and I'd buy the silver if it was still there when I returned. I suppose it might've been a family heirloom.)
Nuts! That's shady! I hope you get it resolved or find another app that does what team viewer does.

Maybe one of these will suit your use case.
https://alternativeto.net/software/teamviewer/?license=free
How the pandemic made fonts friendlier
Other countries are reporting otherwise, typically in the tens of percents down. Singapore, Greece, India, Germany, UK, Zambia, Malta, Philippines:

https://www.todayonline.com/singapore/fall-traffic-accidents...

https://www.marketscreener.com/news/latest/Road-Traffic-Acci...

https://www.hindustantimes.com/cities/delhi-news/road-accide...

https://www.destatis.de/EN/Themes/Society-Environment/Traffi...

https://www.gov.uk/government/statistics/reported-road-casua...

https://zambiareports.com/2020/07/22/332-die-road-accidents-...

https://newsbook.com.mt/en/2021-sees-decline-in-road-traffic...

https://www.topgear.com.ph/news/motoring-news/mmda-edsa-road...

These are mostly unchecked secondary sources, of course. But, your secondary source, the "National Safety Council", appears to over-report deaths compared to the Department of Transportation's later figures. In 2019, they over-reported by... 8%.
That's not a thing, really. The GDPR doesn't make any provisions about how you bargain for the data processing agreement.
China is not struggling because they don't have access. They paid for the Russian designs and it came with engineering support.

What China is/was struggling with is the actual know-how of how to make the engines. But by all measures they've almost caught up already.
> Because Americans were helping to finance something, does not make them directly culpable.

Yes, and the same can surely be said of Chinese- we must consider whether to allow this kind of research in the future however

A conclusive "reveal" is unlikely given the variety and saturation of information channels- and with respect although your description of the risks is overstated imo the level of detail you go into makes your comment read uncomfortably like a threat

I think the global distribution of opinion regarding the U.S. and China portends a very different reaction to a hypothetical reveal than the one you describe

Let's strive neither to put actual facts aside nor to grasp for certainty where little exists
CEO is concerned that senior employees won't return to the office to do the important work of mentoring juniors. Instead of incentivizing them to return, CEO threatens to convert them to contractors and take away their benefits if they don't come back to babysit the young'uns. Tries to invoke FOMO. Says remote workers will be emotionally easier to fire.

Sounds like a shit CEO.
CR are not as unbiased as they claim to be. They love Honda cars for example, and my experience with Hondas has been uniformly disastrous. Or may I just got two lemons.
> if you think you're all treated badly in FAANG

No one thinks that. Workload at some places maybe a little on the higher side but still on average monetary and toll on life wise FAANG is probably one of the best jobs.
Australia is in the Five Eyes group, so Fastmail would be mich more susceptible to US “intervention” that a Swiss company.

One could compare that also to Megaupload (NZ) vs Rapidshare (CH) in the past…
sczms, everyshrre
The new rules of the “creator economy”
They do, but they don't have to maintain or pay for them.

The brass seem to think that the F-35 is too expensive to fly to maintain right now.
> when did racial equality become an inherently political topic?

Since literally forever.

Like when wasn't it?