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I couldn't decide if this would be awkward or not before I jumped in. After using it: kind of awkward, but totally fun and enlightening. I was impressed with every person I connected with.

One person called me boring, though. (I am boring)
There are a couple of guys working on custom typeloaders:

https://github.com/jpcamara/Goson

And there is a web framework in progress:

http://ronin-web.org/

But, yeah, it's mostly Guidewire.

Getting a new language adopted is hard.
Clearly by posting, "don't buy this book" on Twitter.
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http://blog.dropbox.com/?p=867#comment-244671740
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Thanks for making it available on Kindle right away. I just pre-ordered it.
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Oh my god yes. As someone who cut their teeth developing software for pharmaceutical research, I can testify that a much of it is absolute crap, by a variety of metrics.
you are looking at the wrong side of the country..
looks like google is working on this. i think it makes sense to roll this out to consumers first and harden it for businesses.

https://plus.google.com/100940716892313727285/posts/Cy9ggc6y...
Its FULL of Aha! moments. Everything you read, you already know, but your brain hadn't quite wrapped around it. So its all obvious, but still profound. I'm still 'Aha!'ing from reading the exponentiation. :)
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That's somewhat of a sensationalist comment. What they're doing is actually very positive and different. TOS are generally viewed as complex legal verbiage that shouldn't be touched with a 10m pole. Many startups avoid dealing with the issue by adopting existing TOS without questioning the harsh and extreme language used. To me, it appears that the Dropbox team is setting an important precedent by questioning, through user feedback, the need for unfriendly terms that have become the norm. To that I say: Good job, Dropbox!
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And it's off again. Google has removed the "send invites" features again. They are controlling the supply so as to create demand.
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Many of the "next-gen" high-throughput whole-genome sequencing technologies are actually PCR using fancy substrates. This isn't that, but maybe it will turn you on a bit to PCR.

In general, PCR is useful anytime you want to isolate, amplify, or manipulate relatively short stretches of DNA.

Do you want to isolate a gene and knock-in a mutation that is known to cause a genetic defect so you can study it? Do you want to tag that gene with a fluorescent tail? Do you need to stitch together several shorter DNA components into a single unit (perhaps joining a zinc finger to a nuclease and creating your very own targeted DNA-cutting enzyme)?

If so, PCR might be for you.
Would love an invite: tony.landis at gmail
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Andrew, give it a try - as I said, really easy to setup. I am thinking of installing it on one of my customers' LAN for their private use.
I wonder how much offering this actually costs them.

There must be some serious file duplication between users especially if they're offering unlimited mp3 sharing, since many people will have the same MP3 files (they can profit off piracy while pretending it doesn't exist).

If they're really clever about it they might even store the data separately (which will increase duplicate collisions quite a lot due to retagging)
Like vs. Plus wrestle match. Go!
Not all companies suffer this fate. As long as people are aware that you have good intentions and have great products they will remain quite loyal.

Apple has the best products and basically good intentions. No one believes Steve Job's cares more about money than making good stuff.

Google has the best products and undeniably great intentions. No one believes Larry Page wants anything more than to improve the world.

Facebook's product is sort of mediocre (as Google+ proved) and their intentions have always been kind of borderline acceptable.

Microsoft hasn't had good products or good intentions in a very long time.
Lasted about 3 hours for me. Invited a bunch of new people, was awesome.
I have some invite left, send me your mail id from my profile or via contact from my website. (both in my about)
He wrote that they wanted to double the size of the field-trial. Pretty impressive how fast that happened. When they launch for real, adoption rate will be crazy, at least for a few days.
I once worked at a smallish company that had been around for 20 years. In that time, they had tried just about everything and had failed at most things. It was very frustrating to work with people who considered things like test automation, normalized database structures, not copying and pasting to be discredited concepts.
Don't use real users as testers, jeesh... Maybe google should invest in some QA.
Yep, it's pretty great. We use it internally and it's pretty fantastic. Curious what XMPP platform you all went with, this was the most difficult part to implement for us and was a little tedious waiting for the CAs to accept the certificates and have it all propagate and everything. We're using Prosody which does have its quirks but maybe there's something better out there.
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> Philosophy went nazi? No, nazism went philosophy, and poorly too.

Yes, the Nazis looked for "intellectual" support, but you're ignoring that they got it. If you want to argue causality....

> They raped Nietzsche's philosophy until it fit their needs, with the help of his decadent Missgeburt of a sister.

Ah yes, the "Nazis were unpopular in Germany" defense.....

>Heidegger is perhaps a much more problematic case, but also not a matter of black-and-white.

Heidegger is "problematic" only if you choose to ignore his actual positions at the time in favor of post WWII revisionism. (In other news, early 1900s progressives were eugenicists and segregationists.)

We can argue about whether that alone make Nazism popular with philosophers of that era or they came to that support on their own, but to deny that there was widespread agreement is simply absurd.

To be fair, Nazism was very popular across all social classes in the 30s, so the intellectual support wasn't way outside the mainstream. My point is that isn't an example where the intellectual class got it right. Do you want to blame that on the influence of the rest of society? (They didn't at the time, but surely we shouldn't believe what philosophers say about their reasons.)
That was an incredibly fast double in terms of user size. Lots of pent-up demand; I know I'd really like for more friends and family to be on.
You don't need a + account to read public posts. The included link though appears to be a profile link and not to a specific post so when I clicked on it a different post was at the top of the stream. The following link should go straight to the post in question exclusively: https://plus.google.com/113882113745075873153/posts/Gbg31WL6...
I pinged you. Would love an invite.
This is really good advice, for those who aren't doing it.

For those of us who are doing it, however, books such as this one can be very valuable for improving how we're doing it.

I've found that some books pay for themselves thousands of times over!
This is exactly how you should put out a fire. As a user I now feel better about Dropbox than I did before the ToS confusion.
circles are like have multiple facebook accounts, one for family, on for work one for friends, and yo can share photos of the last sadomaso party with your friends, without your mother see them
Seems to be having some issues on chrome for me, but it's fun. I rather like it. All people from HN, so I am guessing that helps.
You can currently pre-order it from the iBookstore.

Bonus: It is $5 cheaper there than it is on the Kindle!
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Hi, what issues are you having with it? I'll look into it. Can you please tell me the version of firefox you are using?
Did you know that data being sent as a text message is several orders of magnitude more expensive than sending data to the hubble space telescope (about $8 per Mb)?
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If you look at smartphone platforms you have to
include the non-phone items.

Dude, read that sentence you just wrote again.
sorry for sounding desperate .. but can someone please send me a google+ invite... my google id is 'raghav305'
thanks much in advance !!..
I'm a bit surprised... I have found this to be far more entertaining, and intriguing, than I originally hypothesized...
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At the cost of some user-friendliness they can rework their key management to make it impossible for anyone to decrypt your files unless they have your private key (which you would put in place on each of your computers).
I guess you pretty much nailed it. :\ But by not-so-smart people, I just meant otherwise smart people who just don't WANT to understand how/why circles are different. Its like they're too tied to FB that they don't even want to hear good things about G+ and they dismiss it right away(by shouting abuses about how it sucks and copied fb).
I noticed that a stored cookie was preventing me from signing in g+ after being invited. I opened an incognito window and voilà! I was able to sign in :) Maybe this applies to your case?
In that case, what does the text in my comment mean? If law enforcement is asking you for content, they'll always have some legal paperwork to back it up. Those rare exceptions are pretty much the rule when it comes to dealing with LE.
Amusing, but I had lots of failures... and kept connecting to the same guy after we disconnected.
Sensationalist crap. If the costs to to the company to send a thousand text messages is a penny and they're charging $5 for it, then they're getting a 50,000% profit. You'd think that investors would be car-bombing each other for returns like that.

'Greatest ongoing con job'? Really? When the US housing con job was exposed, the world economy tumbled. SMS con job exposed... people shrug and go on.

I find it somewhat ironic that on a site dedicated to "find a niche and exploit it", there comes this article screaming 'bloody murder!' about business providing a service for a price above the bare bones wholesale cost.
Well, it never connects me with anyone and it says n/a for current users online. I had to use FF.
There's a huge difference between Tim Ferris and Eric Ries. If you made these charges against Ferris, I'd agree with you. Ferris is constantly self promoting, and attempting to cultivate a cult of personality. I know what Tim Ferris looks like because his mug is on everything he does.

I have no clue what Eric looks like. I find Eric makes suggestions that are far less obvious than Ferris. I find that Eric promotes his ideas over himself.

The accusation that this is all just "existing ideas" is kinda silly, given how infrequently this perspective existed even in cutting edge circles like "Hacker News" even a couple years ago.

It has started getting traction, this is true, but 5 years ago, it was a radical idea, and 3 years ago, there were very few practitioners and 2 years ago it wasn't even a movement.

In fact, I strongly suspect that Reis is the source of the ideas that Ferris used in his book.
I am working a switch over to 365 right now from novell groupwise. It seems to work fine if you use outlook. Heaven help you if you want to do something complex like bcc a message or set up a list serve on the online interface.

It just seems to be a re-skin of Live with some group oriented features and I am not sold on it. As to Microsoft being desperate to take the market I can attest to the truth of it, they did a similar deal to keep us out of google apps but with smaller numbers.
This is what my company did.

Honestly, San Francisco is far too expensive to live and work in if you are self-funding.
Really?

OP isn't right that this is greedy either. What your users are doing is an iterative search with a backoff strategy. They pursue one path through the search space, and when they don't find the solution, they remove some links (backing off) and try a new path through the search space.

The clever bit is whether you can automate their decision mechanism for how they're proceeding through the space step by step, and what points you can fall back to when something does wrong (and how to recognize when you've gone wrong).

The fact that people can do this by the seat of their pants somewhat shouldn't come as a surprise to people who study cognitive psychology, but certainly might be a surprise to engineers. After all, that's why everyone who's not a social scientist loves Malcolm Gladwell's books.
I dunno, it seems crazy that Google constantly treats their paying customers like second-class citizens.
It wasn't clear from your original post that your links were in your CV / resume. Should be a lesson to those who want to showcase their "side" projects, LinkedIn profile (heavily checked now days), to put these ON your resume. I consistently fidn in screening Software, Web Dev's and designers asking them if they have an online profile, github, LinkedIn that the answer is yes, but is absent from the resume.
Writing is 90% editing: so is programming.
Sending emails with 14MB attachments will make your sysadmin hunt you down with a pitchfork.
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Psychologically difficult (is their a term here?) for singular decisions to be made outside of chaff to discard. Not just in hiring, but, particularly in hiring :)
Whenever I come across this sort of DIY (or at least low-end) biotech I wonder, "Is this what computers looked like before the PC revolution?" I'm sure that's a terrible comparison, but it's easy to make, and there's just enough substance to it that I wonder if I'm missing out on the next revolution by not being involved in biotech.
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Now compare your numbers to what I got by running a sponsored post just few days ago -

8K+ impressions
120+ clicks ( 1.50% )
40+ comments ( 15 are mine )
20+ subscriptions ( for project updates )
post score of 8-11 ( changes with every reload )

Run time - 3 days, cost - $130.

I suspect that we all here read Gabriel's mega-praise for reddit's self-serve ads [1], but YMMV and it appears that natural mentions are far more effective than promoted stuff... which is not that surprising really.

[1] http://www.gabrielweinberg.com/blog/2010/03/my-duck-duck-go-...
Unlike voice, SMS will be stored in a server and in case your mobile is switched off you will still get the message, when you switch on your phone. So, there will be bit extra cost for maintaining these servers.
As crazy as it is to hire in San Francisco, hiring in the Valley is several times harder. Being in downtown SF, I really don't have to compete with Facebook and Google for engineers, especially anyone coming from the North or East Bay.

Add in a huge amount of local design talent, a city that people outside of California want to live in and would be willing to move to and engineers that are generally happier/more well-rounded.

I honestly can't come up with a good reason to be down in the Valley.
Well, the money has to come from somewhere. You say SMS uses infrastructure that was set up for the voice network. But you could just as easily have said voice uses infrastructure that was set up for the SMS network, which would make SMS a bargain and voice overpriced.

Mobile carriers put enormous amounts of money into their infrastructure. Billions and billions, on top of the tens of billions they paid for spectrum. And they're not charities, so one way or another all that's going to get billed to customers, whether it's voice minutes, SMS, data, or plans with bulk minutes/messages/MB.
People feel guilty if they are inside peering into a computer "wasting a lovely day". Look to cooler climates where there is a reason to be inside.
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lol, reddit looks almost the same
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Agreed, the people that have their vanity domains backed by Google Apps are the hard core user base with lots of influence over other people. The kind of taste-makers that google desperately wants to get on Google+.
I'm curious, what's with the cruddy URLs?

For eg:
https://plus.google.com/113882113745075873153

Why the gargantuan number? Yeah, it's in trial, but still..
You have a wife and a girlfriend? And both are connected to you on FB?
Most peoples' performance and quality of life lowers greatly when the weekly hours go past 30 and these idiots are talking about going to 50 or 60!
MySQL and MongoDB have strengths and weaknesses based on use case. MongoDB isn't a drop in replacement for MySQL and you probably wouldn't choose it for something like a message queue.
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We have a saying on the river:

"Rig to flip, dress to swim."

The idea is that you assume you will flip in the first big drop and your boat will be upside down. So, you lash everything down sufficiently (use secure best practices), wear a flip-line to use to right the boat (have a disaster recovery path), and carry an extra oar (make backups).

As I learn to write web apps I find the required mentalities quite similar. However, I've noticed this mentality does not lend itself well to maintaining good relationships with less serious people. It's certainly a problem I'm currently struggling with (pretty much the classic "buzz killington").

EDIT: Spelled out analogies.
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I'll summarize how this would be used for those new to biotech:

- You buy some primers which are basically chunks of nucleic acid that match whatever gene you want to look at.

- You put DNA you've extracted together with these primers into the PCR machine. This makes lots of copies of the gene you're interested in.

- Then you put the resultant amplified DNA into an electrophoresis gel box (such as the one sold by http://www.pearlbiotech.com/ who also provide free plans. This is also run by Tito Jankowski of the OpenPCR project) which lets you look at the actual genotype (you compare the striations from your sample against other samples or a reference).

Primers are cheap and easy to get hold of and as other comments mentioned there are various software tools for letting you design them (you then place an order with a company like Invitrogen).

Edited to add:

The reason you need to amplify stuff is because biology is annoying like that. Let's use a simile:

If particle physics is figuring out how a watch works by smashing it against a wall and studying the debris

Then biotech is throwing gears and springs into a test tube and carefully stirring at certain temperatures until you can hear ticking.
Am I the only one finding this whole thing fairly uninteresting? It's not like if it was a brand new, revolutionary service. Now I'm not knocking off Google Plus, but it is just a Facebook clone, perhaps better, but all this buzz around how invites are limited and everyone wants to get in seems like an attention grabber more than anything else.
http://news.ycombinator.com/item?id=2717503
Add yourself, its being ran through. Throw your gmail in your profile, or here when complaining about an invite :)
Exactly this.

And it (partly) comes down to something someone else has mentioned already here on HN:

Hire a good PR person.
Last discussion: http://news.ycombinator.com/item?id=2735944

The discussion before that: http://news.ycombinator.com/item?id=2732537
Not even remotely "always". These days, law enforcement will frequently talk to a service provider before they have a warrant, and the service provider will often cooperate without seeing a warrant.

However, the exceptions in Dropbox's ToS and Privacy Policy allow them to do the same under a broad set of circumstances, not just when required to by a warrant/subpoena.
Large marketing firms dedicate resources to finding "trend setters" and "cool kids".
http://www.google.com/search?sourceid=chrome&ie=UTF-8...

Older video: "Merchants of Cool"
http://www.pbs.org/wgbh/pages/frontline/shows/cool/

Or look at a Goog search "marketing trendsetters | "trend-setter"

Lots of noise. The Merchants of Cool is a good relevant watch.
I've run raytracing clusters with 4000 cores. It basically scales linearly. So for this task, or any massively parallel compute-bound task, you pretty much can just add up the cores.

Also, I would rent them by the hour, because if a service has 500 machines available right now, I can get the job done in an hour, instead of 500 hours. Or 10 hours instead of 7 months.

Not something I can do with purchased hardware.
Anyone can give me an invitation.

loren.zhai@gmail.com.

I cannot edit above link.
It might also spawn a new collaboration. There are dishonest people in science, but anyone scooping your work has to weigh the risks of getting called out for it, which is more likely if your software is good and widely used.

I don't believe in the private model, so I release code when it's ready, regardless of where it fits in the publication cycle. It's pretty neat from a reproducibility perspective to submit a paper based on code that is runnable as a tutorial example shipped with a library that the reviewers stand a good chance of already having installed.
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If that's the case, your sysadmin either needs to stop living in the past, or provide something more convenient than e-mail. Storage and LAN bandwidth are ridiculously cheap.