skysight-inc/HackerNews huggingface dataset:
It's that transgenic beta-amyloid mice are not humans with Alzheimer's.

BUT!

As another neuro PhD: this is still an important finding for our understanding of protein (dis)aggregation in the brain. The opposite finding was totally possible. The protein disaggregation could have been independent of CSF flow. The typical HN hot-take is "not so fast, this translational research actually underdelivers," but I prefer, "this fundamental neurosci research has the added bonus of being preformed on a clinically relevant model."
Thanks, I was wandering how they account for the speed of sound but was lazy to google )
Man, I was a hardcore devotee of Ian's Shoelace Site years ago. The Ian Knot [0] has probably saved hours of my life by now.

[0] https://www.fieggen.com/shoelace/ianknot.htm
That makes sense, I misunderstood, thanks.
Plus effortless code splitting.
Notea – Notion like, self hosted note taking app stored on S3
Get the self control. Simple as.
I’m impartial to the 30%, but I don’t want Apple to allow payments to be done via other vendors other than Apple. I trust Apple with my credit card, but I don’t trust epic.

My biggest fear, although I don’t think it will ever happen, is apple being forced to support other stores on iPhone, and someone like Facebook moves their app over due to it allowing them to farm data, or games moving over using their own credit card provider and not knowing where my details are going.
Maybe it works for products and services that are priced based on the costs (i.e. cost + a competitive margin). Not so much if you can do a value based pricing. Which is the case when you don't have too much competition, when you're not selling a commodity.
Wow that sure is a blatant ripoff of Dune 2000.
One thing I would like to know, and I don’t know enough about mortality measures so maybe someone who does could chip in, would be essentially what is the probability of observing a year like 2020 with respect to all cause mortality. Is it in 99th-percentile or are we looking at an observation within a standard deviation of the expected value,etc.
If silly but interesting things weren't allowed, there would be no point to having a website like this. The article is a neat exploration of two things that many, many people don't realise are related because they simply don't know the maths involved in either of the two subjects.
The thread was originally about CRA vs Vite size on disk (or implicitly, if we're applying it to real world applications, network cost in CI job startup times). And like I said, surrogate pairs don't apply to ASCII.

See this[0] for reference. Note how the first byte must fall within a certain range in order to signal being a surrogate pair. This range quite deliberately falls outside the ASCII range. This fact is taken advantage of by JS parsers to make parsing of ASCII substrings faster by special casing that range, since checking for a valid character in the entire unicode range is quite a bit more expensive[1].

IMHO nitpicking about memory consumption of the underlying data structure is a bit meaningless, since the spec doesn't actually enforce any guarantees about memory layout. An implementation can take more memory for pointer to prototype, to cache hash code/length, etc, and there are also considerations such as whether the underlying data structure is polymorphic or monomorphic due to JIT, whether the string is boxed/unboxed, whether it's implemented in terms of C strings vs slices, etc.

Regardless, it doesn't change the fact that the octet sequence "hello world" takes 11 bytes in ASCII/UTF8 encoding (disregarding implementation metadata).

[0] https://github.com/jquery/esprima/blob/0911ad869928fd218371b...

[1] https://github.com/jquery/esprima/blob/0911ad869928fd218371b...
The hurry is if warming temperatures cause it all to sublimate and release rapidly as gas, AKA the clathrate gun.
The Degoogled Android ROM, Now Even Better
Cooperation is no guarantee that you won't be extra-judiciously murdered without consequences either. We have plenty of examples like Philando Castile to put the myth of "just cooperate" to rest.
If Epic wins I would gladly pay Apple for access to the app store. Apple’s review process and the standards they implement provide a lot of value to me. My fear if Epic wins is the iPhone app store becoming like the Mac app store: mostly empty. Because if there’s a way to escape compliance with Apple’s standards and still distribute your app then many developers will take the easy road.
> "The climate is in danger/is not in danger and we should or shouldn't do so and so" is an expression of an idea, and can't be libel.

If I was an employee of a climate action advocacy group, wouldn't publicly stating that the climate is not in danger cause harm to my employer? Should they be forced to continue employing me despite that harm?

Again, I'm not advocating that this person should be fired, but it feels like overreach to say that it shouldn't be possible for someone to be fired for what they say.
Well, in the United States LGBT marriage was instated via an application and extension of customary law, not any statute from Congress or even any overt politics. I see this as being quite compatible with conservative and libertarian values, seeking to remove undue interference from personal lives as much as possible. I'm not sure why you would disagree. Progressive activists may see the political process as the only way of achieving "positive" change, but that's a short-sighted point of view.
If we’re getting that deep into the hypotheticals, couldn’t said person just not set up biometric logins?

For the rest of us where physical coercion to unlock the phone isn’t in the threat model, it really does improve on the trade offs between security and convenience.

Feels disproportionate to say we should not do the latter because of the former.
You have a couple points there. I might change the headline.

Keep in mind that this is the last post of a series specifically geared towards helping people stop gaming.

> If you want to stop procrastinating, you probably should just delete Steam and get on with your tasks?
> I'm not saying it's easy. There are things that can help: Meditation, proper task scheduling, talking to people about your problems, stress management techniques, in extreme cases therapy ...

Naturally, our articles cover the above, as does the book (that you casually dismissed)

And to your last point, technological cures (like the extension on our site) and specific techniques are often the start of the journey. For many people they are more approachable than the "spiritual" approach.
Try also "gource" in cli for a great live video : https://gource.io/
Driving deaths are up:

https://www.npr.org/2021/03/05/974006735/tragic-driving-was-...
Interesting that way fewer people died after the 1918 pandemic. I assume it "weeded out" all the people who were likely to die soon anyway, but what's more interesting is that the negative bar seems to be longer than the positive one, which would somehow mean that the pandemic saved lives? Very odd.
Edit: ignore this post, I was wrong.

> Thirty years on, the test that Thiel and a colleague devised is still the largest experiment ever on the potential impacts of commercial deep-sea mining. Called DISCOL, the simple trial involved raking the centre of a roughly 11-square-kilometre plot in the Pacific Ocean with an 8-metre-wide implement called a plough harrow. The simulated mining created a plume of disturbed sediment that rained down and buried most of the study area, smothering creatures on the sea floor. The test revealed that the impacts of sea-bed mining reached further than anyone had imagined, but it did not actually extract any rocks from the sea bed, which itself would have destroyed even more marine life.

https://www.nature.com/articles/d41586-019-02242-y
That's not how safety regulation works, where the burden of proof is on the potential offenders side.

We don't allow random chemicals as food additives and drugs and recall them if they turn out to not be safe. We show that they're save before we allow them on the market.
I think people are conditioned to expect games with an "exploitative" ad-based or in-app purchase model. The conditioning to not expect an upfront cost to purchase is reinforced by the huge number of low/no effort apps resulting from the low barrier to entry. People don't want to pay for apps with little or no utility, lots of bugs, etc., and that's the vast majority of apps.

It's going to take a big player having the fortitude sustain the marketing (and potential losses) to sell an app that doesn't fit in this paradigm.
'Tragic': Driving Was Down In 2020, But Traffic Fatality Rates Surged

The National Safety Council (NSC) says deaths from motor vehicles rose 8% last year, with as many as 42,060 people dying in vehicle crashes.

When comparing traffic deaths to the number of miles driven, the rate of fatalities rose 24% — the highest spike in nearly a century, NSC says.

https://www.npr.org/2021/03/05/974006735/tragic-driving-was-...
I hope not, I just finished integrating with it at work.
Thank you for the details. It definitely helps understanding what happened and the discussion. Not even checking if the affected people would be likely to transition is a weird move.
No, I don't either. Apple is not a monopoly, so as far as I am concerned they have a right to charge whatever they want in their AppStore and make it the exclusive way to get software on their product. If you don't like it, don't support it with your money. I honestly cannot make sense of the reasoning for any other conclusion.
It depends on the person(like I was different in the past), but today I don't get satisfied by what developers think is challenging. For example in Skyrim I make my own challenges - for example the lockpincking mini game after you played the game a few times is just a waste of my time so I mod it out, I gave up on Neverwinter Nights 2 because of the combat grind, I loved the story but I was not into the min-maxing of characters and fighting same spiders over and over again in a cave and I could not find a "killall" cheat at that time.

I played a lot of Minecraft(though I stopped 2 years ago) , exploring and mining in that game while listening to a audio book is so relaxing, it does not feel as a grind and if you want to build or decorate you pop into creative and do it.

But some frustrating stuff are quests that lock you out from the main story, like in GTA4 was a quest where you had to be super fast on a bike and I was terrible at it, so you have to repeat same shit over and over again or give up (later in GTA V , they let you skip sections if you fail 3 times)
I don't think it is. A ton is an imperial measurement that is close to a metric tonne. A lot of places use the words ton and tonne to mean a metric tonne, but an imperial ton is a different amount if kilograms to a metric ton/tonne.
Ask HN: Who wants to go back to the office?
We are all reading a ton of articles about remote work. Curious who is calling BS!
> "but as I understand it, the most important thing that they care about, even before aesthetics of an art piece, is provenance"

early stage Physical BTC collector here to say yep, chain of custody is super important for collectibles in general. Provenance is king.
I'm not sure it's really a good comparison to pick a subset of European countries and compare them to the whole US. Some countries seem to have handled it better than others, which we could definitely learn from, but I don't think it is a US vs Europe problem like some other commenters seem to be implying. We could also compare Italy, Belgium, Hungary to Vermont.
Exactly. And we've gotten better with cancer, but we've gotten worse with obesity. There's a bunch of layers to apply, so I don't know how factoring in the excess mortality from 1957 or 1942 is particularly useful if you're looking at how much upset COVID causes society.
Try to remember that today you live in a world shaped by environmentalists: that’s why there are currently some rivers safe to swim in / not on fire, why the air isn’t filled with toxic levels of lead, why it’s ok to go outside without immediate sunburn
Maybe, but I still think there's an important point in there.

We (society) do a lot of handwringing about CEO and engineering jobs, but these aren't even remotely the most gender-asymmetric careers out there.

According to [1], "Locomotive engineers and operators" are 92.3 percent male. I'm willing to bet that if you can "fix" that problem - or even conclusively identify the cause - gender imbalance issues in other fields will be less contentious.

[1] https://www.bls.gov/cps/cpsaat11.htm
Coding Stories: Me vs. the VNC Guy (2020)
Because it would give people a better intuitive sense of how bad COVID is in a larger civilizational/historical context.

Over the past 12+ months, people have accepted enormous infringements on freedoms in their everyday lives. Many of the public health measures that we take as a matter of course in the "new normal" - lockdowns, social distancing, extended closing of churches, etc.- are things that would have been almost unthinkable as recently as January of 2020.

If you look far enough back, to some point in the twentieth century, you'll find a time at which the baseline infectious disease risk in everyday life was higher than it has been in the COVID-era US. But people at that time went to crowded theaters, ate in restaurants, packed together in churches and schools, and so on. Restricting these things could have decreased their all-cause mortality, but they clearly found that option unacceptable.

Note that this isn't an issue of whether people "believe in science" or "believe in data". It's an issue of risk tolerance. People a few generations ago understood the Germ Theory of Disease perfectly well, and they knew that they could reduce the spread of infectious disease by implementing the kinds of measures we've implemented for COVID. And yet they didn't implement these measures, except in very minor and temporary ways. We've become far more risk-averse than they were. And the question of whether that's a good thing is not an empirical question.
plantuml is wonderful but the restricted layout control forces you to maintain small diagrams if you want readibility.

maybe that's a pro?
Every time people use money to try to better their lives, somebody publishes a smear piece. Like we don't work to earn, so we can improve things for our families.

"Middle-class American selfishly moves to neighborhood with better schools for her kids! News at 11"
CISSP has a somewhat positive reputation, but lots of the other certs are basically negative signal on a resume.

There's lots of different types of security stuff. If you're interested in the more risk management corporate side, looking at study material for certs like CISSP can be useful (but use it as a starting point of things to learn, dont follow blindly). If you want to learn crypto, that's not the path i would reccomend.
After all, water is only 75% of Earth
"A ton" is a very vague word that can mean lots of things, only one of them being the imperial ton. Some tons can't even be converted to kilograms at all since they're units of volume.
As far as I understood they fixed the first bug. This is a new one.
> Nodules are never going to provide enough to meet demand

My understanding was that this one area is estimated to have more rare metals in these nodules than all land based deposits combined.
I sincerely don't, I don't see a reason to waste time and money commuting every day. As is I hate driving, but even with public transit why do I want to waste an hour or an hour 30 per day.

I've been able to save so much money in the last year, for the first time in my life I would be fine for good amount of time if I got fired today. I very much do expect big companies to force workers back in the office, tons of middle managers don't feel like they're being effective if they can't stare at you typing for 8 hours
I don't know anything about him, but I felt the same way when seeing this. It's such a weird way to get this message out. And the way he's talking sounds very unnatural, like an ad.
> Humans as a whole have never had net positive impact on the environment either.

It's not written in stone. Check out the story of the Loess plateu: https://en.wikipedia.org/wiki/Loess_Plateau#Agriculture_and_...

We destroyed it (it looked like a Lunar landscape) and then we regenerated it.

> Until we can determine the impact, I don't see why it should be banned outright.

You're inverting the logic: you don't set fire to the house and then "determine the impact" afterward.

Keep in mind that the cure for cancer isn't down there, cheap fusion isn't down there, the fountain of youth isn't down there. We don't really need those minerals, we just want to make money. But the time when profit was more important than living healthy oceans has passed, surely?
You are confusing confidence intervals (used to say that you are confident the increase is positive at all) with error margin (the false precision in the 3rd significant figure).
Russia has been pretty damn effective at this. (I took note of this when moderating r/europe on reddit when things started churning in ukraine)

China on the other hand not so much.
I might go trough the effort of finding them again but someone here shared some American studies that showed china initially didn't really have such a presence of bots and the like on twitter, fb, etc like Russia at that point (i think around 2016 or 2017) but there were notable networks of bots targeting chinese people with anti china stuff.

A second study showed that i think 3 years later China had also gotten into this but that it was comparatively small scale and notably incompetent.
Sure, but then again viewpoint diversity isn't a universal good to be chased at the expense of everything else :)
You're missing that there are marginal trips that would be discouraged/eliminated if one had to pay for them.

There can be subsidies for low income individuals if one cares about the regressive aspect (I don't). Low income individuals can use carpooling to escape per-person fees, as well.
Some factors might include increasing usage of microservices, frontend SPAs, serverless, and more early startups looking to integrate with enterprises, who now have high expectations of what's possible thanks to Auth0 and the like.
I'm curious if there's a good way to breakdown how much is caused by COVID vs., say, caused by the lockdown (i.e. delayed elective medical procedures, suicides, etc.). For example the US suicide rate declined from 2018 to 2019, but went back up in 2020. Naively assuming that all of the increase was due to the effects of the lockdowns would attribute ~2,880 suicides to them (or more if in a counterfactual world the suicide rate was going to continue declining if there hadn't been a lockdown). Obviously the real causes of these suicides would be difficult to impossible to determine with certainty, making this a difficult path to explore.

In the UK a study predicts a 7.9-9.6% increase in breast cancer deaths within 5 years of diagnosis due to diagnostic delays caused by COVID. For other cancers their estimates vary, i.e. 15.3%-16.6% for colorectal, 4.8%-5.3% for lung, etc. thelancet.com/journals/lanonc/article/PIIS1470-2045(20)30388-0/fulltext

Basically I guess what I'm really trying to get at is that while COVID is certainly a terrible disease, there seems to have been little to no cost-benefit analysis performed by policy makers regarding the lockdowns and other attempts to combat it.
I'll take the bait.

Planets that are capable of sustaining human life are scarce. Putting aside the divisions on our maps, we have a total of one ocean. Since we have exactly one planet to live on and one ocean to sustain life, I'm gonna go ahead and call that pretty scarce. There's a massive amount of water but if we ruin that one ocean, I believe we all die.

So now it's time for a judgement call: what is so valuable at that depth that you're comfortable having people poke holes in it hoping to determine the science is good and worth the risk?
> The environment would be in much worse shape if industrialization had been fueled with wood rather than coal

Wouldn't a wood-powered industrialization period have incentivized the growing of trees?
This is analogous to saying "an umbrella is better than a toaster". They are two different things.
How is Rahul Gandhi far worse?
Have we seen him as a PM yet?
Or atleast as a CM? He is still with a surprise, yet.
We trusted 7 years of borderline dictator who thinks he is unquestionably great and is causing deaths of lakhs of people with his egoistic approach to the issue.

Our country was never structured to be a duopoly of parties, we could have 28 regional parties elect a PM from among them, a PM who is answerable to all states, a PM who works with credibility to bring justice to all. Rather than two bad choices.
Scientists re-evaluating relative brain size and mammalian intelligence
Billionaires are more concerned with not losing their money than they are with growing it.
This is probably one of the most fragile, delicate ecosystems on the planet. It could take 100 or 1000 years to recover from the sterilization.

Low-impact? We have very different definitions for that phrase.
I don't understand your argument. You're saying that because people didn't mind dying from infectous diseases at a time where scraping your hand could prove deadly, we shouldn't mind it today either?
Litestream Eliminated My Database Server for $0.03/Month
Paxos raises $300M to build a cryptocurrency infrastructure giant
What does Blockchain and Cryptocurrency mean to you?
An Iain Banks Culture Orbital is optimal, yes. But "perturbs" is a weasel word. You can 'perturb' the environment without destroying it, or you can 'perturb' it and leave a desolate wasteland where nothing grows.

I'm hardly an environmentalist, but for a personal example, my home happens to have a well for drinking water, a perturbation of the environment that's perfectly sustainable, we use less water from this well than the watershed on my property restores to the aquifer. This is an acceptable perturbation IMO. That well is contaminated with polyfluoroalkyl substances from Scotchgard-treated leather scraps. It was too expensive to dispose of them safely, so Wolverine leather buried truckloads of the toxins in a local swamp. This 'perturbed' the environment, turning the place into a Superfund site, making the entire aquifer toxic for decades to come, and should not have been done.

If underwater mining just makes a depression in the seafloor with little other effects, that's probably an OK perturbation. If it releases heavy metals into the water that travel with the currents for miles and miles, killing much of the wildlife, that's an unacceptable perturbation.
My mental image of playing a (3rd? 1st?) person shooter on a table is like, is horrible. How do the controls work? Do you just pair some controller and prop up your iPad on a surface in front of you? Or is the controller attachable like a Switch?
I think Epic is right, 30% is too much. Apps market is competitive and margins are already slim with cost of marking, advertising, development, and maintenance. I get Apple offers a great experience and no cost of making apps accessible.

None of this would be an issue if iPhone/iPad was open to non-apple app stores. Apple is being greedy here, can't install your own apps (non app stores) and can't have an alternative to app store so what are people left to do.
I agree on a longer time scale. It seems like moderate success of the Chia network would be a prerequisite for someone to invest in building that.

My comment was responding to my interpretation of your claim to mean a single entity is likely responsible for the majority of the 1EB, and that could be accomplished for $20M. Based on my own observations over the past few months, I believe the network has been bootstrapped by a wide variety of hobbyists and a few larger scale operations, with far more than $20M invested overall.
I don't think it is any more plutocratic. It's about the same.