skysight-inc/HackerNews huggingface dataset:
Oxygen concentrators without the antidote for oxygen toxicity [0][1] won't help very much.

All the repurposed drugs that are useful have anti-inflammatory properties. @farid__jalali, an MD on twitter, is trying to get a study for the anti-serotonin drug Cyproheptadine going. He's observed several patients get pulled out of death spirals I guess. He's written a paper with some colleagues explaining the role of serotonin in severe COVID-19, and is trying to get this published.

Dr. Jalali has run into medicine's "gatekeepers". I suspect his actual problem is that repurposed generic drugs that saves lives leave money on the table, and undermines the Emergency Use Authorizations [EUA] the vaccines are sold under.

Cinaserin is another anti-serotonin drug that'd probably also be useful for treating the serotonin storm [2] associated with severe COVID-19: https://twitter.com/TaxiCabJesus/status/1385260243492380680

[0] https://news.ycombinator.com/item?id=22993262

[1] https://news.ycombinator.com/item?id=25883728

[2] https://en.wikipedia.org/wiki/Serotonin_syndrome
The advertisements were never shown- they were just added to their internal systems and were (thought to be) approved.

>The findings were revealed in a report, released today, by lobby group Reset Australia — the local arm of a global initiative working to "counter digital threats to democracy".
aksuhally...

https://drinkingage.procon.org/states-that-allow-underage-un...

turns out the laws are a little complicated.
I don't think he argued that by being white he might have some advantages, although it can be argued especially these days. His point was that there are million of other parameters that can affect ones life experience, so why just one advantage in the skin colour department makes him priviliged when he had so many other disadvantages in other departments.
It's anecdotal, but unfortunately I'd say that the experience is much the same in single-payer Canada. I have never had a GP who is not trying to rush me out of their office as they seem to get paid by the amount of patients they see, not the quality and depth of care they provide. I now declare I have X questions up front and then work my way through them, ignoring the GP's repeated attempts to bring the appointment to a close before I'm ready.

Health care is massively broken everywhere. I don't know how we move the incentives in the system to quality over quantity.
Vietnam and Thailand would disagree.
It's almost always Stackoverflow that ends up giving me the answer!
I don't buy that philosophy for short-lived things that haven't had a chance to be acted upon.

If a system is in place and continues to do a thing after concerns are brought up, then absolutely, that's an argument that can be made; but, for each new class of mistake a system makes, you can't just say that that's what it was designed to do.

It's unfair to the designers, the people in the know, etc. You'll never win people over by telling them the thing they attempted to create, with many years of sweat and tears, was _designed_ to do something nefarious if it wasn't.

If they don't change after evidence to the contrary, then this can be brought up; but before then, it's inappropriate.
You've got this backwards.

1. The average American is considerably wealthier than the average European.

2. Cars are so expensive in Europe relative to America due to regulations/taxes/etc which are applied by governments (the alleged protectors of the people's welfare).

3. You've got causation backwards in regards to infrastructure, the US infrastructure is the way it is BECAUSE cars are cheaper, cars aren't cheap due to the needs of infrastructure.
Companies - specifically large public for-profit companies - are amoral entities solely concerned with maximizing their profits. That Facebook acts seemingly without any morals isn't all that surprising.
Agreed. It's "the stores are extracting too much money for the services they provide and the way they run" without any concrete asks. Likely because we're in unexplored territory, I expect ACCC is using this release as a form to push other agencies to move first to see what happens.

Australia NEVER moves first on these things. They want EU or US to make a move first to see what works.
Pass laws to make it illegal to advertise to people under 18.

We somehow expect FB to arbitrate but that’s just not possible. It isn’t even their fault in the end - they operate within legal boundaries.

We should make it unlawful to advertise to people under 18 and prosecute offenders, harshly.
Different kind of pre-installed.
Projared, a youtuber, got his business destroyed and was falsely labeled a pedophile because a group of kids coordinated a release. Unless a conviction is secured, a coordinated statement is meaningless if you care about justice.
>but, we should recognize it for what it is, not some nefarious, evil plot to harm the young of multiple nations.

no, it's much worse. Nefarious evil plotters at least need to sleep and eat and eventually they might grow tired of their evil scheming. This is much more miserable, this is simply the invisible hand doing its job and harming the young of multiple nations with a ruthless efficiency and precision that makes most comic super-villains look sloppy in comparison
Jeez i'd lose my fucking jaw laughing if antirez loses sleep on that.
> What are we paying the NSA and CIA for if not defense against foreign attacks on US infrastructure?

The CIA seems to exist primarily to conduct attacks on foreign targets.
>the more house prices are juiced

More institutions are buying homes and competing with the homeowners, because bonds are very-low yield and the stock market overpriced in terms of P/E.
> Am I though?

Yes.

> She posted a joke on Twitter mocking the idea that white people couldn't get AIDS.

Even if you believe the subsequent backtracking, that's still a profoundly stupid thing to be doing in that circumstance, and it shows a complete lack of any critical thought as to how your actions and words are perceived.
Why would all social classes be the same in motivations and goals? You can never trust the "loyalty" of groups they never signed up for.

A mining company owner, a wall street trader, a tech start up millionaire, a head partner of a law firm and old-money heir(ess) would all have different interests and goals. The same goes for lower classes as well.
Drinking under 21 isn't illegal federally:

https://www.law.cornell.edu/uscode/text/23/158

It's just that if your state doesn't set their drinking age to a minimum of 21, they'll lose a big chunk of federal highway funding.
I have multiple small side projects running, and cannot afford to have an expense of more than a few dollars each per month. It’s a fun project to try and reduce costs as long as your priorities are straight.
Social class may very well be highly correlated with competency - even moreso than any other information a hiring manager may have access to - and therefore a good indicator for a hiring manager to use.
Nope. But you should check out Embedded Artistry[1], its the single best resource I've seen on a field that's mysterious even to most professional programmers.

Have you spent any time doing Arduino projects? While not representative of real-world firmware work, Arduino is very accessible/cheap and will teach your transferable skills (e.g. C programming for interfacing with HW). I'd encourage you to really put some time in before you commit to anything embedded - because the amount of jobs and the range of companies you can work at is much, much lower than "mainstream" development (say, building web applications).

[1] https://embeddedartistry.com/beginners/
It's so hard to talk about something like this objectively because momentum of the mob towards the popular discourse makes it almost impossible to detach.

The woman does not say she was raped or anything happened to her without her consent (unless I missed that in which case I apologize and retract this comment, but I couldn't find it).

The person currently being cancelled was a "community leader" (apparently) but was not her boss, teacher, or in official power over her. It sounds like he is a creep who manipulates women to be with him. What specifically did he do differently from any other guy who tries to "woo" a woman?

These women consented to be with him at the time for the perceived benefits of being close to the community leader and what comes with it. They are adult women who made decisions. Now they want to retrospectively apply alternative morals to their actions at the time because they wish they didn't do that.

You did this, it didn't happen to you.
How in the hell can you expect advertisement in the 21st century to not reach minors? We might as well legislate that all minors must wear blindfolds at all times, or be blinded as they’re born.
> and not all due to the cars: some of it was a mind shift that mankind had to make

Mostly it was due to regulation.
Here is an uncommon one I came up with (not using any clever spacing or Unicode characters):

Never enough time, only enough weighting
If you think the staging area is unintuitive you should see what emacs magit does( and I love emacs magit). You stage A, start typing a commit message, stage B, finish the commit message, commit, and lo and behold B isn’t in the commit. So in magit it feels like there’s a secret second staging area.
China Announces First Population Decline Since 1949
I'm not sure if you mean that's a lot of ads or not but I thought creators chose where the ads are played.
Yes. It is absolutely illegal. Not sure anywhere where this would be legal. Ie. "TV or radio ads about alcohol cannot target children. They also should not be irresponsible in targeting adults." https://www.acma.gov.au/ads-alcohol-tobacco-or-therapeutic-g...

Edit: changed the example
Then choose something else? I mean, lobby for the change if you like, but you're eliminating my favored choice if you succeed.
What happens when things fail is an absolutely critical part of design / architecture. It's disappointing that interviewers works consider that an unimportant detail.
> I assume this matches the 'load bearing' criteria as I only use variable width spaces

I think you might be stretching the rules slightly with that stuff.

Using "medium mathematical space" (U205F) instead of an ascii space seems pretty clearly to be using a special character for the purpose of manipulating the hash.

I'd much rather amulets be created not by messing with invisible codepoint differences, but rather by making more typographically distinct entries and picking out ones that are correct.

When I saw "generated", I thought "have a thesaurus suggest word swaps", not "manipulate invisible unicode characters"
Privacy like tracking your app launches?

https://www.cnet.com/news/apple-says-itll-change-how-it-coll...
Agreed. Instead of expecting a for-profit company to decide what’s ok we should simply pass laws that makes advertising to people under 18 illegal.

For instance if your social media account says you are less than 18 then it should be illegal to show any ad to you.

This will have the additional benefit of internet communication technology companies having to rethink kids as a profit center.
Iterable CEO says he was fired for microdosing LSD at work
Try making a React Native app using Expo. You write JavaScript on your PC (but you can access native functions) and the app will automatically refresh on your phone near instantly.

You can later eject it to an Android Studio/Xcode project if you want.
> 30% YoY growth and on paper profitability, or 45% YoY growth and an on paper loss, with the ability to flip the switch and move to the first option whenever you want?

This sounds suspiciously like a line from the WeWork documentary on Hulu.
If Bob and Alice can't work together anymore because of a non-work related debate they had using company resources, that's a problem for HR.

It doesn't matter if its political or not. Politics and religion are just the two easiest ones to get into a debate about - and religion is a protected class.

Whats more, if either of them are fired and they claim a wrongful termination because of that debate (on company resources) it puts the company in a very awkward place of both previously encouraging that sort of discussion and discouraging it.

If you want to debate politics, go set up a non-work email list or slack channel.

The office isn't the third place ( https://en.wikipedia.org/wiki/Third_place ) and discussions of politics belong there - in the third place.

Discussions of politics in the office with managers and people reporting to you and needing to get along and not being able to leave without forfeiting a paycheck - those are things that make the office a bad place for debates on politics - especially the debate of the CEO's political stances on things that extend belong the product the company produces.
Ask HN: Do you have to do leetcode when applying to DevOps/Linux Roles
Hello HN,
I’m just curious to know that do you have to do leetcode when applying for DevOps or Linux related roles
Thanks for the clarification. That does make sense but I guess I have a hard time coming up with use cases for it. That doesn't mean they don't exist of course!

In my mind unikernels in the cloud specifically don't seem that different from Unix, because you're running on a hypervisor anyway. If you zoom out, there could be 64 OCaml unikernels running on a machine, or maybe you have 10 OCaml unikernels, 20 Java unikernels, and 30 C++ unikernels.

That looks like a Unix machine to me, except the interface is the VMM rather than the kernel interface. (I know there have been some papers arguing about this; I only remember them vaguely, but this is how I see it.)

It was very logical to use the VMM interface for awhile, because AWS EC2 was dominant, and it is a stronger security boundary than the Linux kernel. But I do think the kernel interface is actually better for most developers and most languages.

And platforms like Fly are running containers securely: https://fly.io/docs/reference/architecture/

Apparently they use Firecracker VMs which are derived from what AWS lambda uses internally. So I can see the container/kernel interface becoming more popular than the VMM interface. (And I hope it does).

To me, it makes sense for the functionality of the kernel to live on the side of the service provider than being something that the application developer deploys every time. Though Nginx, redis, and sqlite are interesting use cases ... I'd guess they're the minority of cloud use cases, as opposed to apps in high level languages. But that doesn't mean they're not useful as part of an ensemble, most of which are NOT unikernels.
Just to expand on this a little, firmware development is hard even for experienced engineers. My experience is with bluetooth firmware but from what I have seen the problems are pretty typical.

For starters, the tools are generally terrible compared to things like Jetbrains or vscode. Each chip vendor has a preferred environment (i.e. Segger for Nordic stuff) or you have to buy something expensive like IAR and they all have quirks. The Ti toolset for bluetooth stuff is a nightmare.

Next, you need to be an excellent C programmer and it helps to have some experience with assembler. You will need that for debugging. If you struggle with pointers or memory addressing or anything like that you will suffer.

Next, you need a good understanding of concepts like interrupts, how data is stored i.e how memory is used for different data. Plus each RTOS is different so while strategies for how you do things are similar, the available tools can be unique to the vendor.

On top of that, you will likely have to work with the hardware engineers on how the chip is set up, which pins are attached to what, how they are attached and other concepts like SPI and other means of getting data in and out.

There is a lot to learn, you need to learn by doing and hopefully with an experienced mentor available. There is nothing like stack overflow to help either, the chip vendors run their own forums and try to help but largely on a custom board you are on your own.

So, no bootcamp could even come close.
Funny, I had the same thought when I was in my teens and couldn't ever imagined it until Simpsons did an episode [1] on this where Homer got his dream job at Globex and the CEO/Company is the dream boss - provided a fully paid for house, flexible hours, great pay, beautiful company town, easy going colleagues, CEO that trusts you, etc.

It was only halfway through the episode you realise that Hank Scorpio is the stereotypical james bond villian and everyone working for him (including homer) was helping him in his diabolical schemes! But you wouldn't know it if Homer didn't re-sign from his job while Hank was battling Bond. :)

[1] https://www.youtube.com/watch?v=8Ew78KThLOY
No one is arguing that blockchains don't require a priori out-of-band agreement between the human operators on what the rules of the network are in order to work. Please don't be daft, and try and stay on topic. All distributed systems require this.

What is being argued is that each PoS node requires an out-of-band indication as to which fork is the canonical fork before it can boot up. Nodes in PoW systems do not need this -- the protocol lets them figure it out automatically.

Considering that the whole reason for building blockchains is to minimize the trust required between the humans that build and operate them, this puts PoS systems as a whole at a disadvantage -- booting a PoS node requires strictly more trust in other humans than PoW.

Also, just because your preferred blockchain undergoes hard forks all the time because it lacks protocols for in-band upgrades and for multi-stakeholder decision-making, doesn't mean that all blockchains are so lacking.
What does that have to do with this?

I do agree though and would go further and make it illegal to show ads to anyone whose profile states they are under 18.
Sounds like you don't want an iPhone. So buy a different phone that does what you want.
What we need is to not have events that disrupt our supply chains.
By consumers do you mean the loud but very small minority that defend Apple in comment sections of online articles?

Because if you ask me, my guess is that the average Apple consumer couldn't care less if the platform is opened up or not.
"current generation has to clean up what the previous generations created" considering all my 20 year old friends zeal for bitcoin it won't be us cleaning it up either, good luck to the current 5 year olds
I’d agree if this was the first time bad behavior was uncovered. And it’s not just FB, Silicon Valley seems to have a big problem with big systems that, like Frankenstein, escaped the intent of their creators and fell into this algorithmic evil maximization trap.
What makes firmware programming particularly harder?
That is not how ethics and laws interact. The law sets a minimum standard that can be enforced by the government with a penalty. No matter what Facebook does, they are not deciding what is or is not legal.

Ethically, you often have an obligation to do more than the bare legal minimum in order to not be a horrible person.
I'm not a any kind of crypto expert, but I'm wondering if this looks like a config file? Let's say you have a JSON file that has one field, which is the key, base64-encoded.

Maybe you won't change the algorithm, but still want to leave room to add another config parameter. The file format is obvious in a text editor and it's easy to add more stuff.
While possibly true, we need to attack it from that angle. If you look at a person and go "you are evil!!" you win no one. If you go to someone and say "I'm seeing some behavior in the system you designed. Was this intended? It's harming people, can we fix it?" you recognize them as human and don't assume harmful intent. Then, the both of you can work to solve the problem. If you go at it the other way, you're attacking _them_ and they'll defend by arguing that it's an emergent behavior of the algorithm and there's no evil intended.
When watching TV during a football (Aussie rules football not soccer) game I see probably 15-20 gambling ads and so would the 0-17 year olds watching. There is also an ad with Matthew McConaughey drinking whiskey, although im not sure if that's during prime time or late hours. Never seen a smoking or vaping ad though.
> In hex for example; 3, B, C, D and E all sound very much the same.

We have a standard way of dealing with that in the form the NATO phonetic alphabet.

So 3BCDE would be “Tree Bravo Charlie Delta Echo”
Job market is just a market, and there is no law on how much employer should pay. Employee chose one company over another on an absolute number basis, not on the ratio.
I believe those instructions do not work anymore. There's a project on github that will build an appropriately old ubuntu vm that runs open genera pretty well provided you have the source. You can also find the source tarball without too much hassle on some torrent sites.
Perforce has a product called Helix4Git, which apparently allows you to use Git with Perforce. Is it something you tried?
Or slightly more comfortable —- create a temp branch before doing something. Of course that’s basically the same thing under the hood.
Most people are downright hackable and consistently bugged to that effect regardless of strata. Low key mannerism mimicry (not obvious enough to make it look like you are mocking them) consistently gets you received better along with "proper faking" of desired emotions. For some dumb reason they think "proving they can change their apparent true selves on a whim" means they are more trustworthy instead of less.
I am a developer with over 10 years of experience. I wanted to create a way of learning programming topics in a simple and easy manner.

Microideation is a shorts-based app that contains topics in programming explained as 30 seconds read. Each topic has links to other related topics and you navigate them using swipe gestures.

This was developed as a personal part-time project during the 2020 lockdown period. Currently it's all self hosted and also I have created over 200+ shorts ( ideations ) on following categories.

Java

Spring framework

Data structures & Algorithms

Databases

React

There are also ideation series that explains a particular concept as list of related shorts. All the ideations and series can be viewed and switched using simple swipe gestures.

I request the HN community to check it and provide feedback on the concept and implementation.

I intend this to be a community driven platform where experts ( ideators ) can create content on their area of expertise that can be discovered by the interested users.
This is probably the first time it's being reported in a meaningful way that their system enables targeting children for illegal products (presuming vaping is illegal in Australia or the United States for those under 18, which is a separate question, since the only one that passed looked like a vaping product if I understand what I saw in the article)
Why AI is harder than we think
This is such a “le late stage capitalism” sentiment that I see posted all the time. It completely misrepresents the responsibility of a public company to operate in its shareholders’ best interest.
If I were a shareholder I’d only expect them to operate within the law. Or if the CEO was unsure then hold a shareholder vote (though I’d rather the CEO do their job and not bother us).

In the end it is the democratically elected people’s job to make the laws in the public’s interest.

Ban advertising to minors.