skysight-inc/HackerNews huggingface dataset:
Peanut butter is nice. Sadly, it's not easy to get peanut better in the UK anymore now that they have left EU. Can't bring the peanut butter back from NL.
Everyone posting here confidently saying that the FDA is clearly wrong is pretty disappointing to me.

I think of all the comments about how "MBAs" and "marketing people" just don't get software development. And then I look at software development people who seem to think they clearly get medical research and regulation.
There's not, just like there's not any presumption that BBC reports about Russian forces are not lying. So one should weight all the information and choose which one to believe. I expressed my point of view which might be wrong. There's absolutely no reason right now for Russia to invade Ukraine. They had plenty of time before. They have to finish Nord Stream 2, so they absolutely don't want to impose any additional sanctions on themselves. While US have all the incentive to break bonds between Russia and Germany and to prevent Nord Stream 2, so they commanded Zelensky to start a war, hoping that Russia will join it and Europe will be forced to impose additional sanctions.

Russia could have attacked before. Russia could attack later, when Nord Stream 2 is finished and Germany is on hook and won't go anywhere. But right now it's just the wrong time.
I was planning on getting the J&J because I will most likely only be able to get one dose. Is a single dose of the mRNA vaccines effective in any meaningful way?
> but to consider their niche life-style as something more desirable than an average life style.

I don't see how this follows as a rebuttal of the gp comment, if anything it says (to me) that the US is _not_ in decline because we're willing and able to have conversations and make progress on what should be accepted in modern society. This comment feels like a soapbox to me rather than contributing to any sort of discussion, because nobody can comment on _what_ groups you're referring to, and there are no sources to be had. Very disappointing.
For me, this feeling comes from how Rust APIs are typically built. They embed enough information about allowed usage that shooting yourself in the foot is not trivially possible (unlike C).

I guess one could say APIs expose functionality on the level somewhat similar to C++, with builtin strings, vectors, and other high level data structures that are namespaced and are also objects. Whether that is more C-like or Python-like is for the reader to answer.
Certifying Multimedia News Content for Fake News Defense
If certain corners of the Internet oft derided as right-wing whackjob conspiracy theorists are to be believed, not only is China betting that the West is in irreversible decline, but is covertly actively sewing the seeds of the factors driving that collapse.
1. If Jeff Bezos or Amazon would disappear tomorrow, would it make poor richer? No.

Would it improve Gini coefficient and society would be more equal? Yes.

2. Would taxing Amazon tomorrow make poor richer? Yes.

Would it improve Gini coefficient and society would be more equal? Yes.
>landlords also hold little risk

Feel free to expand upon the argument of real estate as a "little risk" investment.

>Renters are stuck by leases

Leases are on average, an order of magnitude shorter than mortgage loans. Less exposure, less risk. Your leverage is to walk away after a year.
I bet they would prefer to be a part USA, France, or Japan at least, if not brainwashed.
Unnamed USS Enterprise (NCC-1701-D) personnel
> after a while with a comfortable living situation people tend to vote against their own self-interest

There's probably some truth to that, but i don't think getting cozy is the only explanation. The "engineering of consent" is a thing, and in an era of mass corporate media owned by vicious psychopaths, proper information/journalism is hard to come by. Noam Chomsky has plenty to say on that topic, if you're interested
How much of a productivity boost would you’ve gotten from java or kotlin which provides a lot of those features with all the complexity and build times?
This is misleading. If you’re young and healthy, the chances of dying from COVID are basically zero. The chances of dying from a blood clot from a rushed vaccine are not. The people who died from blood clots probably would still be alive had they not taken the vaccine.
Living life by ultimatum is pretty lame.

End of the day, requiring such a high friction approach to addressing basic issues sets up incentives to take no action.
The trick to trolling the future is effort.

The more effort something obviously took, the harder it is to suspect it's just a troll.

And this is why I think our generation of Internet people are perfect for the job.
No, the rule I stated is what is actually implemented.

Like all type checking technology, the rule is about static behavior, not dynamic behavior. So halting problem is irrelevant.

Rust accepts all programs that follow the rule in static behavior. It's not a subset, and it's not a best effort to prove. It's the complete statement.

"Access" means source code construct to read or write. Rust doesn't care whether the construct is actually executed in runtime.
Thank you, you're right. That's an important detail. I haven't tried any Flutter mobile apps, afaik.
A city guide curated by places, now in Copenhagen
The future of coding link in the parent has a large list of similarly spirited projects. I have scattered lists of similar projects but none handy or packaged well. I'll point you to the Ink&Switch article on end user programming. https://www.inkandswitch.com/end-user-programming.html
And encourage you to check out personal sites of the people involved. The lively kernel is a programming kit project that's been around in various incarnations for a long time. https://lively-next.org/ The history of Eve (also linked by that future of coding page) is rich and full of references to other projects http://witheve.com/ VPRI similarly is a gateway to lots of history on personal computing http://www.vpri.org/ of particular interest to me there is the graphical language Nile and the meta compiler Ohm. http://worrydream.com/ Bret Victor's site is another gateway you may have heard of, and the researchers at Dynamicland are also well worth exploring. More future of coding resources https://github.com/d-cook/SomethingNew

For more actual environments you can use I recommend https://observablehq.com/, https://starboard.gg/ and emacs along with the links above.
If it's only a physical thing for you, you might give the orthogonals a try.

That's where I want to "go next", but I've not yet seen anything on the market equivalent to the average Kinesis (solid, programmable, not horribly expensive, not requiring soldering).
Yeah I agree. You'll have better luck if you just go to indeed and apply for something that interests you. My most awful interview experiences have been from the jobs I've applied to on HN Who's Hiring or Stack Overflow's jobs board. It's clear the kind of people they're looking for are the hardcore CS types and not the casual (but highly experienced) business application developers.

Also - sometimes you just need to get your foot in the door somewhere that's not too picky and caters to what you're looking for but pays slightly lower than what you want. Then prove that you're actually as good as you say, so you can ask for a raise. I did exactly that with my current employer. After 4 months of being there and proving myself, I asked for a 35K pay raise (about 27%!) and got it almost instantaneously.
How would you test the extent of the mRNA's/DNA's impact within the cell?

Is it possible to do something like tagging the molecules with radioisotopes and following their path?

Here's an example: https://www.nejm.org/doi/full/10.1056/NEJM199001253220403
Nobody would actually write this, it's just a demonstration of the pattern at hand for the sake of discussion
China has always been extremely good for its top students, providing them with all they need to excel. Once China becomes a global superpower, I'd imagine many of them go back to working for China if they get the chance to with their new-found expertise from abroad.
Wouldn't it still be difficult? The HJKL row makes sense to remap to DHTN. But other commands are mnemonic and would make more sense to follow the key to its new location.

So you have collisions. ("Does Y mean "yank"? Or does it now mean "to"? Well "to" can't be T anymore, because that's now the motion up command.")

So you have to either remap everything back to qwerty positions, and learn the new mnemonics, or keep the letter associations the same, and give up on the clustered motion commands.

I'm thinking it's probably better to do the latter, but I'd love to hear from vimmers that use non-qwerty layouts.
64*127 = 8128, normal i2c is limited to 7 bit addresses. There are extended i2c addressing setups but I believe that requires every chip involved to support them.
I don't like China and find what they're doing in Xinjiang abhorrent (and I believe that the Western media reports are truthful and not just made up shit), but that part of the article made me wonder if the West has been or is as bad, but the Economist (and myself) ignore it because, "Hey, we're the good guys!".

There isn't a lot of outrage about miners of rare minerals with dangerous working conditions or poorly paid Bangladeshi textile workers, or the slave workers building the Middle Eastern countries (at least not to the level where western politicians talk about sanctions), is it because these people are suppliers for our Apple, H&M, or that they have a lot of oil and money which we wish to attract?
This bothered me too (need to believe in a Higher Power), but they do have a statistically significant success rate versus no group therapy, which is a net benefit to society I think
Also ignores risk by age group, which can be significant and relevant to someone’s risk profile.
Because China doesn't like it when people point out that they have concentration camps.
On the other side of the story, I interview senior developers/tech leads for a large bank and it is difficult to find people who can code their way out of a paper bag. Lots of candidates can sweet-talk their way but then show complete lack of problem solving abilities, disorganized approach, inability to predict if their code is doing what it is supposed to do, etc.

Realize, when you go for FAANG job you are competing with a lot of younger people, frequently just out of school with fresh memory of CS topics.

There is a lot of other companies with just as good compensation where your other qualities (like maturity) might be more advantageous than in lowest echelons of FAANG.
Name one time in history when the group burning books and censoring people were the good guys.
>In this example Iraq doesn't have a meth problem because meth is the problem, Iraq has a meth problem because of mass poverty.

The article does paint a bleak picture of life in Iraq and I understand how a lot of youth can end up addicts. Taking drugs is something they can do feel better for a while and is something they actually have control over in their lives unlike the rest of the country's problems.

Morally, would it be wrong to ship in tons of anti-depressants and give them away free to make people feel better about their shitty situation?
The New York Times article I posted calculates the math differently. For instance, the Great Depression was a deflationary period, not inflationary.

In any case, my point still stands. Whether we're talking 10, 15 or 20 years, the wealthy hold on to their wealth. And if we ever enter a long-term recession, wealth taxes could be reversed as easily as they were enacted. But why would we? The Great Depression hit the poor much harder than it did the Rockefellers.
I'm not a biologist, so I could be completely wrong here, but I disagree with you.

First of all, plasmid != viral vector. That's why the Nature paper you cited had to use electroporation to introduce the payload. As J&J is a viral vector vaccine, I would not be confident in using this paper to make the argument that an adenovirus-based vaccine could modify a host's DNA.

Second, your article does not make the claim you think it does. Specifically, the discussion says:

> Using simple intramuscular injection, the vast majority of plasmid DNA that persists is extrachromosomal, and the frequency of integration, if it occurs at all, is negligible.

> However, even if the residual plasmid in the gel-purified genomic DNA did represent integrated plasmid, one copy... would be at least three orders of magnitude below the frequency of spontaneous gene-inactivating mutations...

That is, the delivered gene does not integrate directly into the genome itself, but rather stays in the cell. To detect whether the gene stays in the host cell, the article compares molecular weight and uses a PCR test. Both methods do not tell us whether the gene inserts itself into the host DNA; one way to detect that would be to sequence the subsequent DNA, which would be monstrously expensive (because the modification incidence is extremely low).

The only way that a gene might integrate itself into the chromosome is if during DNA transcription, an error occurs and the foreign DNA is merged onto the host DNA. But this would be incredibly rare because it would require most base pairs to match up between the host & foreign DNA; otherwise, the cell would attempt to repair itself or induce apoptosis.

And even if the resulting base pairs match up, the resulting DNA might not have any behavioral differences because it's (approximately) the same sequence of characters. (And you would need another transcription error later on that happens to reduce the non-modified strand by approximately the same length. That's also extremely unlikely.)

Fourth, the Pfizer and Moderna vaccines use a mRNA-based vector, which (in my limited knowledge) is very difficult to integrate into the genome. The most plausible mechanism I could imagine would be:

1. (Optional) an enzyme which converts a modified nucleoside mRNA strand into one that mimics the mRNA chemical structure that is compatible with a reverse transcription enzyme [1].

2. A reverse transcriptase to convert the mRNA strand into a (foreign) DNA strand.

3. A restriction enzyme that cleaves the host DNA suitably so that the foreign DNA can be inserted.

4. A matching ligation enzyme which actually inserts the foreign DNA into the the host DNA.

All these above enzymes do not naturally occur in humans, so DNA modification through this mechanism would be incredibly rare.

[1] https://link.springer.com/protocol/10.1007/978-1-4939-6481-9...
If you are a Russian "president" and have domestic troubles like a crappy economy and lots of Covid, always remember the 34th rule of acquisition "War is good for business".
It's an essay published in the "Arts & Culture" section of a literary review. It's not "hard news". It's not supposed to be neutral.
That's a cool thought. I always imagined it be something like a the K-T boundary (1), a thin layer of rock that looks different than all of the other layers.

(1) https://en.wikipedia.org/wiki/Cretaceous%E2%80%93Paleogene_b...
Well, just to answer the question very directly, iOS as a whole isn't rated 17+ because it can't be. Obviously. It's not an app, it's not present in the App Store, and it has no age rating. So that takes care of that.
Bill Gates is doing far more good for the world with his money than the US government would.
There are two problems here. Rust accepts a subset of correct programs that involve borrowing, that's absolutely true, but it gives you the tools to get around that: you either use Arc<Mutex<T>, where now you are in the same space that any refcounted GC language is in (with the extra flexibility that if you can "choose your guarantees"[1]), or use unsafe which lets you dereference memory freely in the same way that you would in C or C++.

The unstated problem is that there are patterns from other languages that are actually invalid and Rust is correctly denying, but not properly communicating it, which causes frustration. You can always make the argument that the failure modes are benign or rare, and for those cases noone is stopping you from actually using unsafe.

[1]: https://manishearth.github.io/blog/2015/05/27/wrapper-types-...
> Your point about other vaccines being available is totally valid and sound, but... what is our standard here, then?

The standard is not to distribute a vaccine with a known side effect that standard treatment protocols will catastrophically fail for without pausing to get information about it to healthcare poviders needed to implement protocols to identify and properly treat it.

That’s explicitly what the pause is for per the article.

> The number of known blood clot cases with the J&J vaccine seems to be 6 in 7 million.

It’s not, because the effect is seen 6-13 days after vaccination, and much of the 7 million (per the article, 6.45 million is the most recent cumulative figure I can find elsewhere but its two days old, if both are accurate that's over 0.5 million doses in the last two days...) J&J doses that have been delivered are within 13 (and even 6) days. And the clots have all been in women 18-48, who aren't the only people getting the vaccine, so, unless that’s a fluke (and the numbers are small enough that that’s merely unlikely but not implausible) the prevalence in that demographic is even higher.
Haven't the Ukrainians diverted important rivers upstream on Crimea? Undoing that could be the concession Putin is hoping for.
An actual war with the thousands of troops they're moving? I don't know, I hope not.

Surely Russian leaders remember how the war in Afghanistan affected the USSR. It was a massive waste of money and resources, and it played a big role in destabilizing the whole regime.

This would be similar, imo, if NATO backs Ukraine. Russia will just waste money, destroy lives and whatever prosperity the region had, for little to no return. Maybe they get two more republics into the federation.

They're just pushing Ukraine, Georgia into NATO and everyone else away from them. What a sad state of affairs.
We stopped being a community not because we are a free society, but because we stopped communing.

This pandemic has been a comical caricature of how people have been living lately; siloed in their own homes, only interacting through an internet connection. This has made us incredibly susceptible to realities distorted by interested parties.

Again, a free society is our only way out of this. When I get my vaccine in the coming months, I'll be dedicating as much time I can to building strong communities. I encourage all to do the same, no matter how silly it seems. Join a hackerspace, a rock climbing group, volunteer at food shelters, become a scout leader... anything, so long as you promote community and togetherness in doing so!
Well, it's like saying that wearing a straightjacket makes you a better person.
Request: Zoom with Ctrl+Scroll.

I imagine this might be quite useful to understand data-flow, but I worry that it would be tedious to manage the connections via positions during development.

It would be cool to have an auto-format/auto-layout:
- data flowing left to right
- draw pipes like yahoo pipes used to
- minimize crossing pipes.

When in the programming loop, could the connections be established automatically via references? Name each output and then reference it somewhere else, which implicitly establishes the connection. Then click "auto-layout" (or just hit save) and as Steve would say "BOOM".
In the US there are reports of lead and other toxic materials in the tap water.

I dislike China but the US also has those issues, people are just unware of them.
Yeah, kinda wish they'd redo GTA 1969 though.
It's barely sufficient. Much of the docs is in various pull requests from others adding models. In another reply a user posted a better maintained fork repo
Can we exclude certain terms in search with a "-" e.g. "-oculus"?
>just arbitrarily throwing half the resumes out

how else to you filter out the unlucky candidates :)
The Good, the Bad, and the Ugly of System Tray Icons
I don't know of any. I do use flatpak whenever I can.
It's a neat trick, isn't it? Blaming people for being right.
This along with the simultaneous rise in tensions over china/taiwan is concerning.
Just curious. How do you feel about Alabama advancing its "creation science" bill? Clearly, unequivocally there are reactionary trends taking us far in the opposite direction you say we are going.

I will always take the path of science over the path of superstition and manufactured grievances.
Quite sad, glad someone picked up the torch
> Primarily for adding properties

I personally would never expect a property which is treated as a string. That's what POJOs are for, but that is just opinion I guess. still weird they let you do this.

> and making objects that can be inherited from (unlike primitives).

I mean the SO gives an example of how to do it but I would still love to see some place where this is needed or even pragmatic to any degree.
We forget so soon! Housing debt (which is secured with a tangible asset) can easily bring you into negative territory when your home value falls below your loan balance, which happens regularly, as real estate is cyclical.

Also, I'd bet many, if not most, car loans are underwater the first day the car is driven off the lot. Lots of people have to pay additional money to satisfy the loan, after selling their car.
I, personally am ambivalent on this subject. I see many signs that support the narrative of a west in decline while also seeing signs that it still has plenty of innovation and strength still left in it.

The center of technological innovation still resides here in the west.

In the west the industrial and technological prowess are demonstrated through its corporations. For a recent example, look at the speed of development, and efficacy of the vaccines developed in the West compared to the ones developed in China. Beating the west by creating a better vaccine, faster would have been like the Moon landing in terms of raising China's prestige and stature.

SpaceX, despite being only a mid sized company in the US, has a space program that is more advanced that any nation on Earth. Companies like Boston Robotics and Waymo continue to sprout up in the US.

In the event of a total war situation, the west would have a better chance of calling upon the expertise and knowledge of companies like these, much as it did in World War II.

However, things do change. China continues to rise. If it plays its cards right, it can become a rival to, and even eclipse the west. However the fact is, the west continues to be a center for innovation, that pulls in the smartest and brightest from all over the world. People from everywhere, including China, continue to immigrate to it and bring new blood to its competitive economic engine. Feeding the creative destruction of economic and technological innovation. China does not yet have this. It's corporations sit in service of their bureaucracy, its public discourse and innovation is hampered by its great firewall.

A Chinese proverb comes to mind - "We'll see"
Most can be done with one hand on a Mac but I do know what you mean.
Getting closer and closer to the thought police.
I would recommend asking questions on the subreddit. There's a standing thread for asking questions, and people usually give high-quality help and respond quickly
I refuse to stand by while my students are indoctrinated