skysight-inc/HackerNews huggingface dataset:
Recently it was shown that the chemical ISRIB can “undo” traumatic brain injury. It turns out that when you get a concussion, the mechanical stress results in a metabolic self defense mechanism being triggered. Everyone thought the neurons were dying but they were just themselves latent. ISRIB interferes with this defense mechanism, turning the neurons back on.

And it turns out that this metabolic defense mechanism is triggered in many scenarios, not just concussion.

I became involved in a group of people who were interested in taking ISRIB. We engaged in an effort to synthesize it, and along the way we dredged the internet for any information we could find about other people who had taken ISRIB — the molecule has been known about for a long time. There are a handful of plausible stories, and it appeared that ISRIB would have no effect in one person and be life changing for another, both seemingly healthy. The common pattern was increased intelligence, an insatiable appetite for new and novel information and a marked reduction in the amount of sleep needed to function.

We eventually came into contact with a group of Russians. They had already synthesized it and taken it. They reported the same effects from the accounts we had found. They also reported, surprisingly, the development of a tolerance among those who took it repeatedly. One person had an episode of very realistic hallucinations, dreams that seemed real. Another person gave it to his grandmother who was sick with dementia. She became lucid again but died a day or two later. We speculated that one of the reasons cells turn themselves off is because they are too dysfunctional to operate — so turning them back on brings the benefit of having that signal again in the case of neurons but also revives any dangerous behavior that was being suppressed. We acquired ISRIB from the Russians and the first person to get it didn’t notice an effect although he didn’t take much. At this point I fell out of contact because I was having a medical emergency from experimenting with a totally unrelated compound. It nearly killed me, I spent weeks in the asylum and still have lingering effects. After that my shulgin itch became satisfied permanently.

One interesting thing about cognitive diseases that are metabolically rooted like schizophrenia, dementia, etc is that there are simple ways to coax the cells into metabolizing carbohydrates correctly again, as this article demonstrates. There is also another kind of chemical completely that can be used for energy, beta hydroxy butyrate, totally bypassing the problem. The field of metabolic restoration is the next big thing for sure.
Becoming a Software Engineer at Microsoft [Q&A]
I agree. The author makes it clear that using "business" tools like MSOffice and writing a lot of nicely formatted emails is important to him. Wouldn't have switched to Linux if that was the case for me. I'm writing < 10 emails per day - Evolution + WebDav/CardDav is good enough for me.

I'm also on a 2018 Xps with Ubuntu 20.04 and everything just works.

To me, the clear advantage is how installing all kind of obscure R/Python packages is usually a smooth experience, whereas a working Mac version frequently doesn't even exist or requires struggling with obscure errors, especially after MacOs upgrades (e.g. https://mobile.twitter.com/mcmc_stan/status/1186923309662953...)
But what if someone was killed by a BSOD (brown stain of death)?
The Google web suite apps work quite well, in contrast to the Calendar app which I've never managed to get working.

I think the argument is more "How can a power user survive with something so flagrantly non-functional?"
Most SV companies don't track time off since it avoids certain labor tracking and wage accrual:

https://kslegal.com/pitfalls-to-avoid-when-transitioning-to-...

(They tell staff it's a perk for them, but it's really a cost-savings for mgmt. And Americans are afraid to use time off anyway, and still must get approval from a manager.

I was at Netscape when AOL bought them and cancelled the sabbatical. Every 4 years you could take one year off, I believe without pay. For the eligible employees, it was a big deal when it was cancelled.)
> For instance, `apt install htop` will only ever install the 2.X version of htop in Buster. Including security patches and all, but you won't get a 3.0.0 version without going sideways and add a specific repository for that. Debian will ship with htop version 3 in the next release, but you'll have to upgrade the entire distro for that.

Debian has an official backports repository if you want that behavior. It just gives you the freedom to choose.
No way I can list them all, but here's my top five:

1. Start menu is awfully designed, really slow, and doesn't even return exact matches sometimes. Seriously, it shouldn't take that long to launch something.

2. Lack of tabs in file explorer forces me to have like three-to-five windows open, making alt+tab navigation annoying.

3. It's like each app does its own thing with notifications. It does have a decent notification system, it just happens that nobody really uses it.

4. Lack of proper package management makes every app run their own update checker in the background. I easily have 10-15 items in my tray, and have to chase down something essential like Bluetooth across them. And half the time at least one of them doesn't have an icon!

5. Updates. Booted into Windows after about a month, it restarted twice + gave me multiple notifications that it's gonna restart again outside active hours. I only need to use it for like an hour or so.
> It’s just a proof of concept right now, but it’s a very cool concept.

Though metalens need to be heated, it's a very cool concept!
How to Be an Atheist in Medieval Europe
"High end expensive workstations" with 25-MHz 680x0 processors.

OpenStep ran on a 486 without FPU.
You have to be doing something out there if text rendering in Terminal of all things breaks after an update.
If I were them I'd mine unpopular coins hoping that they go up in value during a general bull run in the future. That way you're quite likely to end up with a decent number of coins.
So, does "Just Work" now include easily accessible noob-proof configuration of the things you want? In that case, macOS doesn't Just Work for me, because I want to be able to see what apps are playing sound or recording and manually set them to different sinks/sources, maybe even have sound playing from multiple devices at the same time. On Linux with PulseAudio and pavucontrol, this is effortlessly configurable with an intuitive GUI. I'm not even sure this is possible on macOS.

My point is, unless we agree on roughly what features are required, "Just Works" is a useless subjective specifier. We all have different priorities, so we either have to accept that there's no universal way to evaluate OSs or agree on some subset that really should Just Work.

By the way, KDE Plasma has pretty comprehensive GUI settings on power-related settings. I think having GNOME 3 and Ubuntu be the de-facto standard Linux experience is actually harming the perception of desktop Linux. People switch expecting a customizable, power-user friendly experience and get a DE that's trying to be the opposite.
The worst part is. China didn't change. Its just that now one perceives the propaganda machinery of a totalitarian power masterfully manipulating democratic activists & sensitivities and wielding them like the tools they are.

Every time one sees "news" out of china, by a chinese news source, one is being talked to by one, single entity.

The wishful thinking that there is a democratic, liberal society behind the imitation game, is by now a dangerous delusion.

And furthering the goals of this voice, is support of genocide. Those who did will have to answer for that. Cheering on a todays stalin or hitler, because you are in opposition to some factions of your democratic society, makes you a complicit in their atrocities.

Doing business with those force drafted henchmen kept in with mafia methods, makes you a criminal.
Nobody said that, you just put words in my mouth. Decreasing alcohol consumption is a positive thing, no doubts. Governments nanny-sitting people makes them dumb.
I don't think this is correct by law. I'm pretty sure you're required to file a return if you earned any income in a fiscal year.

That being said, de facto you are correct. The CRA will chase you if they think you owe them money, but is happy never receiving your returns if they owe you money.
Related xkcd

https://xkcd.com/327/
for 1. The cons? A super restrictive platform (even more than it was under intel)
You can still boot arbitrary unsigned OSes - Apple still allows this, but it is obviously going to take time for other OSes to grow support for apple's custom hardware. So it's still a computer you can control if you want.

for 2., wayland is still a very rough experience imo (I periodically try it on an all-intel system, which ought to be a good target as everything is OSS supported, etc). Lot of apps still don't have native wayland backends (although this is improving!) and it seems generally less stable than boring old X11 for me.
Your own number is presumably not so old.

How many of those 50 do you still remember?
This has been my main music player app for the past 2 years. What I love about it is the offline nature of the app for security reasons and the queues feature.
I was thinking of when water gets over boiling point and then is disturbed:

https://en.wikipedia.org/wiki/Superheating#Occurrence_via_mi...
I mean this depends on your projects. But if you are bootstrapping and have high costs you are prolly doing something wrong. At least in my point of view.

My digital projects rarely cost more than the domain and server they are running on (plus time that is). But again i dont know your projects
Musicolet is one of those no-nonsense and polished android applications that are becoming more and more rare these days.

The interface is really clean, the app has many useful features and honestly, the whole UX is smooth and intuitive. I'll go as far as to say I've never seen a music player software on Windows or GNU/Linux that is as well-crafted as this. (Clementine[1] comes close but sadly it seems it's not maintained anymore).

If you've used Xperia phones, it is similar to the Walkman music player [2].

[1] https://www.clementine-player.org/

[2] https://www.gizmobolt.com/wp-content/uploads/2014/10/Sony-Wa...
I used XML and didn't like it:

- A proper editor was never around.

- Closing tags were verbose.

- Attributes vs tags was confusing.

- It didn't map "naturally" to common data types, like lists, maps, integers, float, etc.
Totally agree with you on this. We're reaching a point where the services some private companies provide are becoming too important to remain private, or at least, being served in a monopolistic fashion where the user has basically no power.
The ITER project has no plans ever to boil so much as one gallon of water for public power. It is 100% a "research project", yet not even planned to try out until 2050. Then, maybe start a production plant after they finish experimenting, maybe in time for 2100 if everything works out perfectly. Which it won't.

If $10B is hard (i.e. impossible) to justify for proven fission, how about $100B for fusion? $200B?

Nobody involved expects ever? to field a competitive Tokamak power station. Not in their lifetime, not in their grandchildrens' lifetime. That is not the purpose of the project.

It has a different purpose. Its main purpose is to provide employment for hot-neutron physicists, to maintain a population to be available to draw on for sporadic weapons work. Another purpose it shares with a lot of others, to provide a reliable long-term conduit of public funds to select private hands. The hot-neutron physicists are not getting those $billions, but somebody is.

Every penny spent on ITER is stolen from other possibly viable projects. Imagine how many GW-years could be generated by 2050 by solar and wind paid for out of what is earmarked for ITER.
Even for small stuff? And which managed k8s would you recommend?
I feel sorry for them. Taxes really should not be hindering oneself. However taxes should reflect a portion of your earnings, so if your price is right i dont really see how taxes could stop anyone from earning money.

Only about 1 of 3 or 4 of my projects work out financially. And this is after doing this for 15+ years, 5+ exclusively. What i am saying is you cant expect it to just work on the first time. It took me over 5 years to reach the minimum threeshold of an adsense payout.

IMO most people never get there because they stop WAY to early. Earning money is less about your actual skills but more about your specific online selling skills that you only get from doing
How to buy and listen to Audible Audiobooks on the Kindle
This is why i love JSON. It's only string, number, boolean, arrays, objects/dictionaries, unless you write custom serializer and deserializers..
https://youtu.be/eRtpmtIivco
I use tmux (inside mintty) on my windows work laptop to pretend I am on Linux. Have been using this copy paste feature regularly too. Didn't realize it was so niche. Tmux is easily the most indispensable piece of software for my workflow. How else would I jump across different work spaces at lightning speed?

For people unfamiliar with tmux these are some other features I use -

C+a . space -> switches layout from vertical to horizontal and back
C+a . , -> lets me rename the window so I know what I have open there
C+a . [ . C+s -> search in previous output. n lets me me then jump to next occurrence of what I am searching.
With weights, you can have the user enter individual weight edges between root and task node, which would simplify the design, no?
In a related story, we (my sharehouse) pay $5000 a month for rent in hard cash, and our landlord declares $2500 a month to the ATO.

As a back of napkin calculation, between her >=2 rental properties, and due to negative gearing, she's declaring a $60,000 loss per annum on her rental properties. Combined with the 50% deduction for capital gains on property sales, I don't think she will pay a single cent for the income earned from her rental property investments.
People have been predicting the decline of US hegemony for over thirty years now. It rears its head nearly every time there’s a major US policy failure.

Every time this argument is raised it’s now ‘Yes, but now is really the time.’ But why not after the Cold War, when a multipolar world was widely predicted? Or after Iraq, or the Arab Spring, or the financial crisis?

If COVID really is the trigger, I’d argue that people have had a good taste of China-style authoritarian restrictions on freedom and movement over the last year, and I’d say they didn’t like it very much.

It’s got to the point where in the absence of any new and compelling evidence, such claims have to be treated with a little scepticism.
I have an XPS 9370 and it feels rickety and poorly made. It can't be opened without holding it with both hands. The screen gets smears on it from getting in contact with the keyboard. The bezels scratch very easily. The light from the LED in the power button bleeds out from the edges. The charging brick makes a high pitched whine when being used.

I use a MacBook 2015 for work and that feels much nicer and has better build quality. I don't plan on buying another XPS.
Win XP was better. You could specify where to put the window by keys and put n windows in tiles over the screen.
I agree that you don't need i3 for the common scenario (IDE + terminal in my case). i3 is more about the myriad of uncommon scenarios that come up all the time.

For example, maybe I want to keep an eye on several terminal commands at the same time. With i3 I just press the terminal shortcut n times and I have n new terminal windows sharing the space. If one of the commands fails with a long error message I press another shortcut and the terminal windows are now tabbed and full height, with the IDE still visible on the side.

Or maybe I want a small browser window or Slack window in a corner to keep an eye on a meeting or discussion while I work.

Whatever uncommon layout best serves my needs right now, i3 can get it done in seconds.

You never really need a tiling WM, though. i3 just solves my problems really well, so well in fact that I actively enjoy using it. Some people feel the same way about vim, and you never really need vim either.
That’s a shrewd observation. Static types help with this somewhat. E.g. in Inflex, if I import some CSV and the string “00.10” as 0.1, then later when you try to do work on it like

x == “00.10”

You’ll get a type error that x is a decimal and the string literal is a string. So then you know you have to reimport it in the right way. So the type system told you that an assumption was violated.

This won’t always happen, though. E.g. sort by this field will happily do a decimal sort instead of the string 00.10.

The best approach is to ask the user at import time “here is my guess, feel free to correct me”. Excel/Inflex have this opportunity, but YAML doesn’t.

That is, aside from explicit schemas. Mostly, we don’t have a schema.
Ah yes, the simple solution to many problems: violence and war.
Yeah. And then you connect two monitors with different scaling factor. Turns out X11 can't handle this and Wayland is still broken

Actually, this works fine in Wayland. I have used Wayland without any issues with amdgpu, including with mixed-DPI screens with GNOME's fractional scaling. However, things go downhill once you have to use X11 applications, and you typically do. E.g. JetBrains IDEs are a train wreck with fractional scaling enabled in GNOME on Wayland.
"Hey we're not removing your ability to speak, just your tongue!"
Big tears.

Start ups are extremely high risk. If that’s not your cup of tea then go work for a mega Corp with better medical and retirement benefits.
Actually the Fed is well positioned to deal with a drop in demand for USD: it can make trillions of dollars disappear by adjusting its balance sheet.

The recent money creation has given them a lot of flexibility going forward. They now have a huge reserve that can be used to fight inflation without having to raise interest rates sharply.
Agreed, but weaponizing the USD against other sovereign states may have backfired.
I think on sites like HN - even with non-controversial subjects - you have to say "improbable" instead of "impossible" and stay away from absolutes.

Maybe "zoomable lens with no conventional moving parts", or "non-mechanical zooming" or solid-state zoom lens or...
Docker is installed different on Linux (as Docker Engine) vs. on Win and macOS (as Docker Desktop). A workflow or team assuming either would run into issues on the other. Most importantly Docker Engine runs as a service with root permissions whereas Docker Desktop implements a VM that hosts its services, with workflow implications for development where a host process and a container needs to communicate.
Never's a strong word, seems quite easy to understand why to me. You've got ease of use reasons, historical reasons like the mis-guided Robustness principle, etc.

And these sort of things happen time and time again.

And although officially JSON requires quoted strings, almost none of the parsers actually enforce that, and so you will find a huge amount of JSON out there that is not actually compliant with the official spec.

Just like browsers have huge hacks in them to handle misformed HTML.
This will make for the best conspiracy theories ever, if it happens

Closing the economy because of fear of a virus first found next to a Chinese lab, triggering a shift in currency dominance to China?
Oh it's great of you're binding c++. Template magic, magick-er than boost, didn't think it was possible but it works really nice out of the box. So nice it inspired other libraries in other languages. See Ada-py-bind on github. Still some code to write by hand but the abstraction is quite nice.
In Canada, when you sell the type of things you usually sell at a garage sale, it triggers the "personal use property" rules. It essentially removes any profit from items as long as they are under $1000, so you're safe selling stuff at a garage sale without tax implications.
Will try it out. Having said that it is on my Linux machine "for free". I'm not even quite sure if I'm allowed to use these paid apps on the Macbook Pro I've been given.
I've been interested in recording music using free software on Linux. The exchange above is similar to the cycle I've been in... encountering problems, finding magical incantations that fix things in some ways but often involve some sort of tradeoff, and making gradual progress toward being as productive as I am using Apple's Logic.

But I've been doing this three steps forward, two steps back routine for like three years now. I have most things working but it has really taken the full force of my frustration with Apple to keep returning to it and making progress.
Sorry my point was that it wasn't a crime.
I just finished a consultancy gig with a startup where the CEO expected every employee (almost two dozen) to handle the extremely high risk, while doing nothing about managing the risk... I’m sorry but I feel your idea is transmitted through foggy lens of corporate hate.
> In Unix everything is a file. Files are files, folders are files, disks are files, your keyboard is a file, your mouth is a file, the air is a file, you can't breathe, your file lungs fill with files and you try to scream but only files come out oh god Dennis how could you do this

-- https://twitter.com/TartanLlama/status/1375045731644538882
I think this might be issue with given laptop.

Some non-apple laptops sometimes reduce badwidth of thunderbold 3 (e.g. in mine t490s the bandwidth is halved, just because - this is hardware, not linux).
And we never denied this. The original argument was that whether or not the religion permits loopholes. If a Muslim chooses not to follow particular teachings of Islam, that's on him, but not because there are "loopholes".
Yes I agree, the UI is a mess and they have made some bad design decisions. One time I was on train with my network connection dropping constantly and Thunderbird was giving me a model pop-up dialogue each time! It still gives pop-ups for updates. But it's open-source, relatively stable and reliable, and that counts for a lot.

The sad fact is that there is simply no money in building email clients. Email is a legacy technology and arguably no longer fit for purpose. We need a new standard and that's not something that BigTech has delivered yet.
You could but for some people the fun is thereby reduced to zero.
Not true. Scholars can differ on the meaning of certain texts, but all the scholars do their best to follow said texts to the best of their understanding, without retorting to loopholes because those are prohibited.
It was not traditionally true in the US -- I agree that "Asian" traditionally meant East Asian in the US until recently, but lately the media has been calling Kamala Harris the first Asian-American vice president because her mother was Indian.
Are they mining with CPU’s or did GitHub actions add GPU’s recently?

If just CPU’s that’s gotta be such a gigantic waste of CPU power for such little crypto.
Former intelligence analyst Daniel Hale pleads guilty
I have that for windows. I believe it came with a bunch of floppies and a book with images of the hints for all the games.

I also have hitchhiker's guide, with the panic sensitive sunglasses (black cardboard glasses with no eyeholes), pocket fluff (a cotton ball) and a microscopic space fleet (an empty clear plastic bag - afaik)
I can see a way this would be useful to use the same abstraction to limit app/user web access to a single domain.

For instance the dropbox binary can only access "/home/dropbox" and "/net/dropbox.com" if this was more well-known/used.