skysight-inc/HackerNews huggingface dataset:
> Like mathematicians, theorists in Computer Science take the greatest pride in knowing and using the most sophisticated mathematics to solve problems. For example, theorists will light up when telling you that they have discovered how an obscure theorem from geometry can be used in the analysis of a computer algorithm. Theorists focus on mathematical analysis and the asymptotic behavior of computation; they take pride in the beauty of equations and don't worry about constants. Although they usually imply that their results are relevant to real computers, they secretly dream about impressing mathematicians.

This is true about all fields that involve substantial amount of mathematics, e.g., physics and economics. In physics (and to a lesser extent, economics) you see a sort of "rift" between experimentalists and theorists very often, with both groups thinking that they are better than the other. Even among theoretical physicists, you tend to see this sort of petty rivalry: high-energy theorists thinking that they are better because they are after the fundamental laws of the universe, condensed matter (both hard and soft) theorists who feel that they are the better lot since their theories can be compared with experiments, hard-condensed matter theorists often look down upon soft-condensed matter theory as being a "classical" discipline invented to bring in more grant money, etc. While there's some truth to all these beliefs, rather than engage in this petty rivalry, it would actually do a lot more good if people just did honest work in their own fields.
Biden's trade chief says US won't be lifting tariffs on China
Aren’t reverse-mortgages big with Boomers too? A lot of them want to die penniless and spend everything lavishly on themselves on their way out. “Let the bank deal with the house after I croak!”
> Rust + LLVM will already handily beat a naive bare bones C or C++ compiler that isn't loaded with sophisticated optimization tricks.

Well - sure. LLVM is loaded with sophisticated optimization tricks. If one compiler does sophisticated optimization tricks and the other compiler doesn't do sophisticated optimization tricks, the compiler with the sophisticated optimization tricks will be faster.

Tangent: Ten years ago or so, LLVM/Clang was touted as being head and shoulders better than GCC, the big new thing, the bees knees. Some of how it was better was obvious to everyone- readable error messages are pretty awesome. (GCC stole that idea pretty quickly) But the big thing that the LLVM/Clang people talked about was how blazingly fast compilation was compared to GCC. It was normal to take 1/10th as long to compile something. The code didn't run as fast as the code generated by GCC, maybe 50% of the performance, but that was a problem that they would eventually fix with more sophisticated optimizers. But compilation was fast!

Here we are ten years later, and LLVM/Clang generates code that runs almost as quickly as GCC. What did it cost, besides ten years of incrementally making the optimizer more and more sophisticated, a little bit better one little bit at a time? Well, it takes just as long to compile something with LLVM's sophisticated optimizer as it does to compile something with GCC's sophisticated optimizer.

The point is, there's a lot of yak shaving that will have to go into making Rust+LLVM work together better. And LLVM is already well acquainted with the barber. The low hanging fruit you're looking for has already been plucked.
In that case, there's no equivalent comparison because one's an employer and the other is not. That doesn't change my original point that the description was loaded.
Chinese companies don’t care much for patents, you already have things like the HQ Pi camera with a decent Sony sensor simply because those are now more readily available.

I don’t think the module itself is protected by patents that would prevent breakout boards especially from Chinese companies, you can buy replacement parts that Apple claims are counterfeit but in reality they are identical to the originals because they come from the same supplier just not from the same supply chain.

The only question is how easy would it be to connect those sensors and make use of them if a lot of the logic that is required to drive them is buried in the Ax SoC from Apple it would be difficult if they use a rather standard protocol then it would rather simple.
True, most pharmaceuticals can't do it now but given the right knowledge, which is known, it can be done relatively fast. I suspect in the next few years there will be many companies that will be able to replicate and advance the process.
Reading the Glassdoor reviews of Engenius makes it sound like a clone of Ubiquiti minus Ubiquiti's weird dislike of automated testing. Still, I hope that there is a decent alternative to UI
Project Euclid: Search 2.5M pages of mathematics and statistics articles
Show HN: Gistmarks, create and share bookmarks using Gists
Have you made any bad hires that way? I used to think that I could gauge someone's depth of understanding by asking pointed questions about past projects, but after doing that several times and following it up with a simple coding problem that they totally flailed around on, or having a colleague tell me that they failed a simple coding problem in their interview, I realized that some people are just very good at faking understanding at that level (talking about code but not actually coding). Especially if it's on their "own" project that they're familiar with and have practiced responses to.
Us folks in biotech have a special tool just for this :) https://blast.ncbi.nlm.nih.gov/Blast.cgi

Unfortunately, the core algorithm dates back to 1990, so it can be real slow in some cases. Biotech takes a while to improve :(
The convention of genomic research is to present all RNA sequences as equivalent cDNA sequences. As this will be the output of most common sequencing platforms.

https://bioinformatics.stackexchange.com/questions/11353/why...
And you work at the Fed? God help us.
Given how many suction cups there are, it seems like it would distribute the lifting force across the top of the box pretty evenly. Like the inverse of the 'bed of nails' phenomena.
https://theintercept.com/2020/10/20/is-the-traditional-aclu-...

https://www.spiked-online.com/2020/02/14/the-aclu-would-not-...

> Indeed, Weimar Germany had on statute what we would today call hate-speech laws, and Nazi propagandists like Joseph Goebbels and Julius Streicher were prosecuted for their vicious libels of Jews. In turn, they used the attention to promote their cause and pose as martyrs.

I recommend reading these articles on free speech.
Overall, I agree with you that making bulletproof arguments is a valuable skill in the workplace.

Communicating "this is what I think of your work, some of it is negative but isn't intended as an attack against you" (without actually using any of those words, otherwise you run into the "my human trafficking shirt" problem) in a way that you're confident your criticisms won't be used against you, it's a skill you can and should train.

But it's work. Like, okay, social stuff is a part of the job, but when you're an engineer in a room with other engineers you'd like to be able to speak your mind without constantly simulating a PR team in your brain.
On the same note: I love the saying that comes up here and other places sometimes "if SpaceX can have pricing on their launches, your SaaS product can provide a pricing section".

If I can't afford it, i'm not of interest to you anyway, if I can afford it, why not give it to me ? Only time I can understand it if you have something highly customized which will greatly affect the price, if not just give it to me.
I think you meant https://www.ebi.ac.uk/Tools/psa/emboss_needle/ or https://www.ebi.ac.uk/Tools/psa/emboss_water/ ;-)
> .docx.pdf

Cargo-cult much?
a) I don't know if protein-folding software is good enough to figure out the exact structure of the resulting protein given just the gene, but I suspect you could figure out through the equivalent of the strings command - looking for sub-chains of the protein, and looking for matching sequences in the gene

b) Coronaviruses happen to be RNA viruses; that is, their genomes are RNA rather than DNA. DNA viruses also exist and are common. We got full genomes from sequencing early in the pandemic, and continue to use it to monitor the evolution of the virus (see e.g. [1], where the results are available for download). Sequencing is very cheap and easy these days - you take a sample from a patient, use chemicals to break down all the cell membranes and such, sequence all of the DNA and RNA in it, and look through the results for a virus genome (i.e. something that isn't a human chromosome and isn't a known virus or bacterial genome). "m"RNA is more a description of the function than the chemical - tRNA and rRNA are short snippets of RNA used for manufacturing purposes inside the cell, while mRNA is the long chunks that actually carry information from the DNA to the protein manufacturing sites. Virus RNA basically functions as imposter mRNA, getting those manufacturing systems to make more viruses.

[1] https://www.ncbi.nlm.nih.gov/datasets/coronavirus/genomes/ - SARS-CoV-2 is the COVID-19 virus. As of my fetch, there are 71,509 full sequences of the virus, reflecting slight mutations over time and space.
T will aggressively protect its ability to pay out that.. [checks notes] 6.8% dividend yield, building out infrastructure really puts a dent in FCF. Not like their customers have a choice anyways!
Either there's something wrong with their measurement or the issue has been fixed. I tried modifying rust-objc's examples/example.rs to add 1000 method invocations, each with a unique selector:

let hash123: usize = msg_send![*obj, hash123];

Comparing the built version with and without the addition, on x86-64 macOS, each message send adds, on average, 52 bytes of code (suboptimal but not terribly unreasonable) and 8 bytes to store the selector name itself (including nul terminator). That's it. Plus 113 bytes for the symbol table entry, but that goes away if you strip the binary.

It's possible that the bloat comes from something else, perhaps class declarations.
Rural?

Your point is valid, but 5/10Mbps up/down is the best I can get in San Francisco.
The device that tells you when your hands are clean
I think HP was actually the pioneer of this. Years ago I attempted to replace a failed (IDE) hard drive in an HP desktop. The (HP OEM) Windows installation failed because the drive (although comparable and perfectly suitable) was not an HP part. I dealt with their tech support for days, and even obtained a replacement (HP OEM) Windows disc. The troubleshooting folks were off their chart and could not help. (I went with a non-HP drive because I could get it more quickly, and it cost half as much as the HP part, and had a better warranty.)

I tried a non-HP Windows installation disc and everything worked just fine. So I was not allowed to install the Licensed and paid-for Windows OS because the hard disk was not recognized as an HP part.

I wasted so much time troubleshooting that it would have been cheaper to just buy the overpriced HP disk. Since that day I have never purchased any HP products, and I have recommended other brands to my clients.
That’s ARKK.
Anycast/BGP traffic engineering is not nearly as accessible as DNS based load balancing. There's several DNS providers you can use to add load balancing and health checks on top of your existing hosting, wherever that is (and you can do it yourself too). Using anycast for this means a specialty hoster, a third party in the data path between your clients and servers, or running your own ASN. I'm sure that gets more precise results than DNS, but it's also a lot more work, and it's harder to replace if the providers involved stop being a good fit.

Determinism isn't necessarily required either. Probabilistic shifting works fine mostly.
Only a portion of it was grounded, not the full length of the ship.

Someone linked a BBC article stating that they shifted 27,000 cubic meters of sand, so there you go, they could likely remove a meter under the whole thing in a similar amount of time (probably longer to cover area instead of digging down, but that isn't what they would need to do).
Free font alternatives: 40 alternatives to popular paid fonts
The April Fools are starting early this year!
Thanks. Yes, I'm sure there are more than ping the server for updates, and a lot more machines that just come out occasionally. It's fun seeing others rework it to support old Intel machines even though it was never built for that. At this point, though, it's just a matter of acknowledging the wall is approaching even if we haven't hit it yet.
> Also a weird tip is change jobs every 2 to 3 years. Companies tend to get less cushy and more process oriented over time.

Hell is an agile sprint system that has been optimised to require 10 hour days.
While it is inaccurate to call it VPN, it's also not descriptive to call it a proxy. It's more than that; it's really a proxy split in half with a private tunnel between the two halves.

So really neither term is good. I don't know of a better one, though.
I could see plenty of "I thought he had a gun" scenarios, we're just chopping off the "...and felt threatened" part. Unless the robot accompanies a group of humans and decides they are threatened by the situation. It becomes "I thought he had a gun and decided the humans with me or around me were threatened". Maybe these robots could be outfitted to coat a person in immobilizing goo or something rather than filling them full of holes. Or long range tasers. Or tranq darts.
I don't disagree, I just think that your average retail investor will never touch a P2P exchange, just like your average retail investor will never own a crypto wallet outside of coinbase.
It is actually sort of strange how compartmentalized the living cell is.

I guess there is some type of redundancy that comes from compartmentalization that is evolutionarily beneficial.
Not anymore. As of a couple months ago its been opened up. anyone (in the service area) can use it.

Relevant blog post: https://blog.waymo.com/2020/10/waymo-is-opening-its-fully-dr...
A pairwise sequence alignment done with `needle` starts like this:

BioNTech_Pfiz 1 -----------GAGAATAAACTAGTATTCTTCTGGTCCCCACAGACTCAG 39
|||||.|.|..|||| ||| ||
Moderna 1 GGGAAATAAGAGAGAAAAGAAGAGTA----------------AGA---AG 31

BioNTech_Pfiz 40 AGAGA----AC-------CCGCCACCATGTTCGTGTTCCTGGTGCTGCTG 78
|.|.| || ||||||||||||||||||||||||||||||||
Moderna 32 AAATATAAGACCCCGGCGCCGCCACCATGTTCGTGTTCCTGGTGCTGCTG 81

BioNTech_Pfiz 79 CCTCTGGTGTCCAGCCAGTGTGTGAACCTGACCACCAGAACACAGCTGCC 128
||.||||||..|||||||||.|||||||||||||||.|.||.||||||||
Moderna 82 CCCCTGGTGAGCAGCCAGTGCGTGAACCTGACCACCCGGACCCAGCTGCC 131
You can just show up (or fake being) in the geofence, open up the app, and you can sign up immediately.
What's even more mind-boggling to me is that container logistics are so cheap that a pair of jeans now goes from Kazakhstan (cotton) via Turkey (spinning) via Taiwan (weaving) via Poland (dying) via the Philippines (sewing) via Tunisia (finishing) to finally be sold in Germany (or elsewhere in Europe) - see http://competendo.net/en/A_Pair_of_Jeans . So, because shipping costs next to nothing (or, at least, it used to), you can optimize your supply chain and find the cheapest alternative (probably also with the laxest regulations) for each and every step in a global race to the bottom. Capitalism at its best...
I live in a suburb in a medium city in Latin America and can choose between at least 4 different fiber providers. The situation in the US is quite puzzling.
Thanks for the kind words, that's great to hear!

We are in a very fortunate position financially (multiple years of runway), and I am YZ. :) We also have companies big and small relying on Plasmic in production. Lastly, you fully own the code that you generate, and can always eject with clean React.
Does anyone know how those get worked into a mutual funds value? I actually have one of those Fidelity SpaceX funds in my 401k but I don’t understand how it works.
I'm able to install the Waymo app, log in (disclaimer-I work for the same parent company as Waymo but I'm using my regular old personal email address) and the app appears ready to let me hail a ride. AFAIK it's fully open to the general public.
Thanks, that is reassuring and makes sense. *at least until we figure out how to put the instructions to make it in the virus code :)
As denoted in the linked article [1]:

"Many people have asked, could viruses also use the Ψ technique to beat our immune systems? In short, this is extremely unlikely. Life simply does not have the machinery to build 1-methyl-3’-pseudouridylyl nucleotides. Viruses rely on the machinery of life to reproduce themselves, and this facility is simply not there. The mRNA vaccines quickly degrade in the human body, and there is no possibility of the Ψ-modified RNA replicating with the Ψ still in there. “No, Really, mRNA Vaccines Are Not Going To Affect Your DNA[2]“ is also a good read."

As far as I could tell, this would work well for getting a synthetic virus into the human body, but without the necessary mechanics within our cell, the special Ψ chemical won't be reproduced by the virus. That'd mean the replicated virus would get snatched up by the immune system as soon as it'd get released from the cell.

Theoretically, a complex enough RNA string could be used to have our cells build the necessary cellular machinery to properly reproduce the virus, but that's a kind of altering DNA that's a whole different can of worms. There's probably cheaper and easier way of defeating the immune system, for example by simply "enhancing" ebola or HIV to make them more infectious and more resistant to our current drugs.

[1]: https://berthub.eu/articles/posts/reverse-engineering-source...
[2]: https://www.deplatformdisease.com/blog/no-really-mrna-vaccin...
from what I've gathered, the rate limiting step for production as of yet, is creating the lipid vesicles and getting the RNA inside of them. Only a few companies have a process for this, and the supply chain for the precursors is limited as well.
I’ve been in that position. If you work for someone that is threatening your livelihood, it’s time to start looking somewhere else for a new job, and renegotiating the terms of your employment.

One of the things my first boss told me at my interview was: if you want to just be a body, you can be a body and there is plenty of work out there for bodies. How well represented you are really depends on how much you step up for yourself. Unionizing is a legitimate option for private sector employees, but they don’t need to expend their employer’s resources to accomplish it.

If you view everyone else around you as just an easily programmed droid, then sure, fairness might matter. I don’t see people that way: they’re free agents and they can make their own choices. Not choosing to unionize is also a legitimate choice, and this vote could go either way.
I think making inferences about what the rational actors you know of will do is quite a different problem to dealing with situations where there is a limit to what you can see e.g. fog or a corner for that matter.
RNA is genetic material, but it encodes instructions to make proteins, which form the physical shell of the virus crucial to its function. As a very rough analogy, the RNA is source code and the proteins are the compiled program.

It's often the protein molecules that the immune system learns to recognise and attack.

RNA vaccines work because your body automatically translates them into some recognisable part of the viral protein, and then develops an immune reaction to that.

If a virus had Ψ instead of U in its RNA, it's still going to be making the same type of proteins. I can't see why it would be more likely to evade an immune response.
Ask HN: With so many copy-cat tools, how do you show your exp is still relevant?
Working as a consultant right now. I just keep running into clients who are almost painfully specific in their requirements.

For example they want a pretty standard data pipeline set up (done that before, in AWS and GCP) - but specifically in Azure (womp womp).

Or they want someone to set up a data warehouse (done that one before) - but they want this specific 3rd party company's clone/packaging of it (womp womp).

For all of these - you can kinda go "yep that sounds simple enough" (and in reality it probably is simple enough) - but if the client wants that specific experience, you are sometimes SOL and won't get the contract.

I keep running into this roadblock it seems. Trying to get actual "flight hours" with every copycat/similar tool that crops up sounds exhausting and intractable (not to mention boring).Is there a good "trick" to selling yourself in this situation?
Ah - thanks for pointing this out! Edited to make sure readers see it.
https://github.com/brianherman/Assemblies-of-putative-SARS-C...
Unfortunately, data centers rarely give 24 hour notice about catastrophic fires or provide advance notice about utility outages when the automatic transfer switch is going to fail.
Ask and ye shall recieve! Have a great day!
I understand it isn't technically necessary but it really is if you're trying to include non-technical retail investors in the market.
>Places like DRW, which by the way never replied back and I sent in my application two months ago.

DRW is a prop shop with a workload comparable to any FAANG. Most certainty not a place you would be able to coast.
Here you go!
https://github.com/brianherman/Assemblies-of-putative-SARS-C...
Everybody has access to rainwater, except the people who don't. I think the analogy works quite well re point 2 (though not point 3).
I kind of want that to exist, actually
I google'd it just for fun, but I thought you had made a really good point....

Sadly, and much to my disbelief, you are incorrect:

MSFT: https://azure.microsoft.com/en-us/blog/introducing-azure-orb...

FB: https://www.wired.com/story/facebook-confirms-its-working-on...

GOOGL: https://earthengine.google.com/

AAPL: https://www.forbes.com/sites/johnkoetsier/2019/12/20/apple-b...

AMZN: https://www.forbes.com/sites/jonathanocallaghan/2020/07/31/a...

If I had more time, I'd run down more companies (Like, who even knows what Slack might be planning! )
Maybe I'm missing something, but why is escalating early and often a bad idea? Isn't that just part of being a responsible adult?
SpaceX is selling a one-time spot on a rocket. That relationship is measured in days, maybe weeks.

Waymo is selling a product that necessarily involves a long business relationship measured over years or months and significant amounts of collaboration. They're simply doing due diligence, like anyone would before entering into a long-term commitment.
The exponentiation signs got lost in your quote. Would you mind adding them back in?
It's really important that these texts have this lightness of mood to engage kids - and the way that so many adults remember Caecilius and family is a testament to how effective it is. Timeless too - I was amazed and delighted when my daughter used the exact same texts.
In similar vein, for Greek we used Thrasymachus, which follows a plucky kid on his adventures encountering various characters from mythology.
A minor point, Jesus has anger issues a number of times in the Bible, not just with the moneylenders. As an example, the time he got mad at a tree for not having fruit and cursed it to never bear fruit again.
No they have allergies to the polyethylene glycol PEG compound in the lipid nanoparticles. It is also used in skin creams, toothpastes, condom lubricants and in larger quantities as a laxative. Some people are just allergic to it.
Yes, I know a few atheists whose fervor walks, talks, and quacks like a religious zealot.
I'd personally buy a 50$ Android phone and install a music playing app.
New York Must Offer Vaccine to All Prisoners Immediately, Judge Rules