skysight-inc/HackerNews huggingface dataset:
> I have a "I'm sure that means something to somebody" feeling.

Break it down! It's not so bad:

> A composition

A bunch of stuff

> a messenger ribonucleic acid (mRNA)

mRNA are cellular instructions on how to make proteins that are read by ribosomes that make those proteins as they read along.

> an open reading frame

This is something that starts with a "start codon" and ends with an "ending codon" and encodes valid instructions to make a protein between.

> encoding a betacoronavirus (BetaCoV) S protein or S protein subunit

The instructions refer to the spike protein of a betacoronavirus, or a fragment thereof, because this is what we want the immune system to pay attention to (and make antibodies to bind to and neutralize).

> in a lipid nanoparticle

The immune system gets pissed off about mRNA floating around, because that's one of the things that happens with active infection. So if you want this to get into cells and tell them to make your protein, you need to encase it so that it mostly escapes immune notice itself.
> As a religious person, it is a bit frustrating that you never see atheists confronting the great theologists and religious philosophers - Origen, St. Augustine, Thomas Aquinas, Kierkegaard, or even contemporary thinkers like Alasdair McIntyre. If Christians' beliefs are really so shallow and stupid, those guys should be super easy to refute, right?

The main issue with most of these philosophical arguments is that they don't prove anything even worth refuting. Almost all of them simply attempt to prove the existence of a deistic God that does not meaningfully interact with the world (beyond creating it or sustaining it).

Deistic Gods by their vary nature don't provide any meaningful knowledge. Believing that there was a creator doesn't provide any useful information about how to help live your life or how the world works.

As a starting point I don't think there are any good arguments for why a person should believe that the bible was influenced/written by God any more than other books.
Looks like they lost their ACH payments processor back in Dec 2020 leading them to prevent being able to handle ACH returns:
https://abc7news.com/beam-financial-app-ftc-lawsuit-fintech/...
Or you create a library which contains a collection of 10-20 line of code modules and share it among your projects.
It would be more difficult to read and maintain any solution to many problems where you are operating on nested objects, especially if the nesting is more than a few levels deep or even arbitrarily deep, without using recursion. Also generating such objects, such as with nested parentheses, is easier as well.
I don't know who the initial customers would be, but it seems implausible that if it suddenly became possible to ship stuff to Mars no one would do it. If nothing else, get some automated methane production going so the ships can come back.

Questionable legal status notwithstanding, it's hard to imagine anyone creating a facility on Mars and someone else coming along later and saying "you don't own that land". Then the question comes down to how much area around a facility can you plausibly claim for your exclusive use. Short of any formal legal agreements, it's basically whatever you can get away with without someone else calling your bluff and building in your exclusive area. I suppose we're more likely to see a Mars real estate land grab if multiple parties (governments, probably) are perceived to be in a race to get the best locations / mineral deposits / whatever. I could see a U.S. / China space race, for instance.

That sort of scenario imagines the money spigot going from a trickle to full blast all of a sudden. Which seems kind of wasteful compared to slow and steady funding starting much earlier, but if no one's opening their wallets yet then there's not much that the people who would otherwise be building this stuff to do about it.
Bad news, it’s not looking very successful right now. Moderna is making back all the lost revenue with the emergency authorization tho
Bingo. Even when you aren't doing animation frames, if you want to structure your app in a reusable way then you are (if you aren't careful) going to get lots of re-renders. If you are using hooks, and have useState/useEffect/useReducer it is very easy to go wrong.

It also isn't re-inventing the wheel. d3 and React are based on fundamentally different models of programming (d3 is very imperative). I have done two or three pretty complex charting apps, and the only way to really break that cycle is to use the dispatcher which allows you to break up the flow of d3...you still end up with a ton of cruft, and lots of confusing constructs (you have to be very specific about what state is needed where and when...for example, some constructs in d3 require data immediately i.e. an axis, and others do not i.e. line, and some constructs require other constructs i.e. the dependency between lines and axis...clearly this conflicts with the data flow of your typical React app quite heavily).
Of course they do. There's a $1.8 trillion dollar market out there (and rapidly growing). There's over $40B of value floating on DeFi (up from less than $1 billion a year ago!). Not only does it behoove Visa to offer onramps and offramps for crypto services, because they collect fees from such activity, but it helps build their expertise in the fastest growing financial sector on the planet.
> you probably don't even know God in Thomas' opinion.

Deus autem est ipsum esse. God is being itself. See Summa contra Gentiles for details.

Or, if you prefer Boethius, see De Trinitate: quod divina substantia est ipsum esse et ab ea est esse. The divine substance is being itself, and from it comes being.
Fuzzing is great for finding crashes and other catastrophic misbehavior. But suboptimal codegen like this would be difficult to reveal with fuzzing.

You could do it with a reference compiler (this has in fact been done before) but finding suboptimal codegen like this case would still be kinda tricky.
I'm super disappointed by recent update to Unify Controller on their CloudKey Generation 2. It now requires access to Internet and a Unifi cloud account in order to setup a local controller. I, like many others, have downgraded to the 1.x version.

And now this BS. Ubiquiti was one company I always rooted for, and recommended to friends. Time to move on I guess (for me, I've already spent many $$$ on my equipment unfortunately.
It didn't happen with industrial revolution, I doubt it will happen now. Robots will not replace plumbers, waiters, teachers, barbers - at least not in the nearest future.
I guess you never attended the Catholic Church? They are quite explicit that gay sex is a grave sin.
There’s no scenario that Beam failing would risk the depositors losing money. Money is held in a FDIC insured bank account under the customers name. Beam is just a pretty interface on top of the bank account.

The holds are the same types of holds that you see at regular banks. Issue is that Beam explicitly made a claim that it only takes a few days to transfer out and falsely advertised an interest rate. Interest false statement is interesting because the underlying bank violated their bank charter if Beam put out false interest rate marketing materials and could be subject to fines.
iPhone shipments grew 55% in the gulf region during Q4 2020
So what moves the new protein out of your cells once the rna is processed? Don’t most proteins stay inside the cell?
> That's much more of a creative work.

Probably worth noting that patents are not required to be creative. That's copyright terminology.

I think the terminology used for patents is something like "inventive and useful".
i'd swear someone changed my comment but no it was me i'm an idiot. it's not even the other larry! sergey brin. sergey brin flies in with a zeppelin & floats the boat.
Apple opens the door to indie repair shops around the world
The lipid container is weird to me. Is that all it takes to send instructions inside a cell? Seems like a security hole. Why haven’t viruses evolved to have a lipid container?
Amazing to see how far inland some routes go.
Mine Bitcoin on a GameBoy (Slowly)
Has anyone tried to sell their work as NFT?
I am not an expert but what I think they mean by 'unlimited' in this context is 'limited by engineering, not limited by 'geology of man made structure.'
You are so right on this, it's an incredible piece of software and easily my favourite sounding piano emulation VST.

The best part is the download is really, really small, compared to the multi-gigabyte sampled solution.

My favourite hardware solution is the Roland series of modelling, I currently use an RD88 [0], which sounds great, and is really good for practice (and it has built in speakers which is a handy addition), and it's small!

The FP series is also good and less expensive.

[0] https://www.roland.com/au/products/rd-88/
I doubt it. It’s a significant source of revenue for a country with limited revenue sources.

End of the day, the big shippers can price in the two week delay to round Africa, and higher tolls could make a competing railway feasible. As it is China will probably have built a rail corridor in a few decades.
At the risk of being uncharitable, "you're using cognitive decoupling" is roughly equivalent to "you're using logic".
People who are "retired" today also work inside the household. They're still making food, doing laundry, and often looking after grandchildren.

Even though retirement has been "invented", 60% of grandparents provide childcare in the US and 27% of people over 65 are still in the workforce.

There's clearly been some change in the past ~100 years, would be pretty weird if there hadn't!, but I'm not convinced there's really a bright line of "retirement was invented, before and after".
Way too many SKUs IMO and I think they’re quite a bit more expensive, aren’t they?
Why haven’t viruses or bacteria evolved to use a lipid nano particle to evade the immune system? Seems like a big security flaw in our cells?
In the US there are extensive laws about capturing rainwater, whether you can use rain barrels, etc. although it's no longer prohibited in any state.

https://rurallivingtoday.com/homesteading-today/is-it-illega...
Yes, because a mounted cavalry is incredibly useful as a defensive force in seige warfare.
I suspect that people who are used to working in small, integrated teams are more used to using the github flow (aka, a web tool to do code reviews which also integrates git commands).

People who are more used to a hub and spoke model - aka, a maintainer receiving tonnes of patches from many different people - would prefer the git email flow (it requires less work from them - patches that don't merge is pushed back to the contributor).
> Why haven’t viruses evolved to have a lipid container?

They have. https://en.wikipedia.org/wiki/Viral_envelope
HarperCollins to Buy Houghton Mifflin’s Trade Publishing Unit
Linux One Liners
Fair enough, I should've taken that into account.

I work from home so the only person who remarks on my hair is my wife, and her comments, if overheard, might pass for misandry. I'm trying to forment a Twitter mob against her in response.
> general intelligence

You might be interested in Jean Piaget's work on the development of intelligence, and his observation on children development and various stages of intelligence.

BTW what is general intelligence in your opinion?
stolen land eh
More accurately "first they came for the weavers."
Yeah I had installed Windows 3.1 and tried IE and Netscape Navigator Gold.

Linux might be a whole other battle to get working but might be a fun project to attempt.
Only true kaiju on the web: http://home.mcom.com/MCOM/images/tiles.gif ;-)
Sportspersons? Infuriating language? Pot meet kettle.
Learning Elixir, Phoenix and LiveView: A Primer for Experienced Programmers
Understanding Engineers as a Designer
I would love to see the output structure from Alphafold of this RNA source code
He is talking about how Dungeon Masters can interpret https://roll20.net/compendium/dnd5e/Wish any way they like.
(never played D&D myself)
Then there are also post translational modifications, like addition of acetyl or phosphate groups, and sugars to the protein (glycoproteins).

I mean, I can understand how an eye or a brain can evolve by natural selection, but I’m still stunned by abiogenesis. I guess we’ll never know for sure how it all started.
I wish git would support signing with tools other than GPG. I hate using it and tools like minisign/signify are a huge improvement.

Hell, the entire thing is simple enough to just be integrated in git.
If the laser passes through some semitransparent things like glass, rain, and perhaps a fine wire mesh, multiple returns would give you the range measurements for each of the things that the beam passes through.
Cancel culture seems to point to the extreme, as in there is no return, there is no atonement, and there can never be forgiveness. I think that completely goes against the general thinking of right and wrong, and has turned cancel culture into a weapon to permanently ostracize people, rather than to correct a perceived wrong.
I am not able to draw the distinction you are trying to make. The more we make machines, especially ones to interact with inputs from our world, the more easy it is to understand our bodies.

Correct, because there is no blueprint then we don't know about how the brains and neurons interact. But if there is a problem with a heart valve we know exactly where and why it failed.

I expect greater convergence in these fields, and as such I can't agree with you.
Nope. I for one don’t worship anything. Everything is flawed and imperfect. But there is still love, happiness, beauty in this world. Right next to hate, despair and ugliness.
Logic - at least rigorous logic - is much more limited in applicability than we'd like to believe.

Religion probably has the most influence over family structure, a topic where it's hard for me to imagine that logic would play a leading role.
The Idris 2 compiler compiles to Chez Scheme; the Idris 1 compiler compiled to C, and the former actually produces significantly faster executables than the latter.

I sometimes see programmers have very strange, irrational purity misgivings a particular case was someone who did not wish to fork off `grep` for some task, but actually wrote his own implementation which broke input into lines and used and manually searched for substrings; — he was initially convinced that this would be faster, or was at least “cleaner” than simply forking off `grep`, and piping to it.

The reality is that modern `grep` implementations are so optimized that writing something that was as efficient would probably exceed the complexity of his entire project.

I have never understood why many programmers seem to have an irrational dislike against forking off POSIX utilities when they target such platforms, and piping through them, which are often far more optimized than anything they've ever written.
> I'm sure it's more complex than I grasp as a layperson, but I'm utterly amazed at how simple this _appears

The genetic code is simple. But possibly not the nanobot that I felt like attached to my optical nerve with a slightly painful prick behind my right eye.

I’m not kidding. I never have eye pain and within a day or two of my vaccination, I had a prick feeling once in the back of my right eye, later accompanied by light coming from within my eye as it was closed in the dark for only a monent for a small part in or close to the middle of my visual field.

I wish I was making this shit up. It was really the only weird side effect, coincidental or not, of the vaccine for me.

The good part is that my vision in that eye has been slightly better since.

I’m not recommending not to get the vaccine. You should get it. But this experience was weird enough to share.

I had a fleeting thought of buying an eyepatch for privacy.
So at 15, I was offered a paid internship at IBM Almaden in the field of dark matter research. Unfortunately, the laws at the time prevented anyone under 15.5 from holding a job (it's since changed to 14). From ages 15-19, I was constantly solicited with interview offers. I could surmise this was based more on youth halo rather than anything else, because what does a kid know?

At 43, I get interview requests for FAANG-level companies several times per year without a LinkedIn account or a résumé. The main things I have going for me are I don't look 43 and I date college girls. Maybe that helps keep me from seeming coasting, declining, and/or stogy. I can't type as fast as I did at 20, but I pace myself (I gave myself RSI from not working-out enough and typing too much without breaks.)

I never want to "retire" but move to different roles and/or fields before either I or the field declines. To me, retirement is death either by boredom, distractions, idleness, or decline.
big mistake, everyone knows you create botnets to spam twitter
Software development is a loser’s game
I've done it before on a long drive under urgent non-work-related time constraints, and while recovering from a broken leg. It's not the worst thing in the world, although finding a tree or a public toilet is preferable, and it's probably not safe while driving.
Its worth checking learn D3 on the observable site https://observablehq.com/@d3/learn-d3.

We talked about it here, with mbostock too
https://news.ycombinator.com/item?id=22675551
It says in the article that everything is immutable, which I found intriguing, but then I see this in the example at mint-lang

fun increment {
next { counter = counter + 1 }
}

Something doesn't add up.
Find eng jobs at over 800 fast-growing YC startups on ycombinator.com/jobs
The moon and Mars have their pros and cons. The moon is closer and has a shallower gravity well. I think Mars makes a better destination, though, mostly because of the atmosphere which provides CO2 practically for free. With CO2, water, and electricity, you can make methane. (Mars might also have easier to find water, but I don't know offhand what the current consensus is on that.)

I don't know if there is any practical way of creating fuel on the moon. You could launch things from the moon without fuel just by using a big railgun or equivalent, but these things will presumably still need fuel to slow down at their destination.
Definitely was a lot of work without CSS.

The <table> layouts are definitely not missed by me.
My mind automatically goes to the XKCD comic - https://xkcd.com/927/

I do agree that the number of tools and solutions out there for creating web applications is overwhelming at times. I just don't know if this a valid approach, especially when people keep churning out tech to replace old tech instead of improving on said old tech.
there's no difference between "private" deployment and "public" deployment. AGPL requires that if the client of the service asks for the source, you are obliged to give it to them.

So if you have a private network, but give a client/customer access to it, and they ask for the source, you will have the obligation to give it to them.
For those reading now it’s not LLVM’s fault. It was a rust change that disabled it
I'm not quite sure. Transition React example is far from d3 version. It achieves only superficially similar result.

d3 version is clear, flexible and composable but react version seems hacky and limited.

I think putting d3 in useEffect is pretty perfect way of merging d3 and React DOM operations.

What are the drawbacks?
Linus Torvalds on Intel and AMDs New Approaches to Interrupt/Exception Handling
I don't own the device but according to comments in this thread it has an ad you can't remove/dismiss and it uses Google Analytics. That is the same monstrosity as web ads.
I tend to agree with you about the "JSX used everywhere", I hate plain logic wrapped inside a component that doesn't render anything but is still designed to be called in a render() (think something like <Fetch url={url} />). It doesn't seem that common anymore, but people used to do it just because it was technically possible, although it didn't make any sense.

But the example you chose doesn't shock me that much. Why do you think draw.circle(150, 77, 40) is saner and more intuitive than <Circle cx="150" cy="77" r="40" />? It's fine to me if it renders a <svg> inside its parent node. Also the named parameters on the second function is a great addition for code clarity.
?? Not once have I mentioned my recreational activities as I really don't use social media much, or play MMO games.. regardless, such activities are as much a part of life as anything else.

I have worked 40 hour/week jobs but they're not really "full time" in the legal sense- I don't get benefits nor other employee-related perks as I am mainly hired to be a permatemp and been trying to build my career as a permatemp.

If those are the only ideas you have, then I would have to at least counter with the possibility there are other (legal) ways to find work, discover the places where interviewing is not important and find work as a programmer there.
https://www.change.org/p/u-s-securities-and-exchange-commiss...
>it seems like there are probably other preventative measures that are way cheaper.

Like doing nothing, and sailing around Africa in the extremely rare case there's a problem.

Makes me think of:
https://xkcd.com/1205/
Writing comedy with and for Dave Chappelle.
Eh I think both the example you've provided aren't the best. A season pass breaks even at most places in 4-6 days if you're going at peak rates. A car rental is much more variable (parking, distance limits etc) but does have a higher mental load than a ski pass. Both would be pretty easy things to hit break even if you're going to be doing/using it. A metro pass is often a much higher break even point. Iirc, when I did the calculations for the NYC metro card, you broke even using your pass to and from 1 place if you left your place every day. Obviously that calculation is much different for each city, but they require a high number uses vs your examples.
Yeah, you're probably preaching to the choir here. The tracking and advertising industry has an unprecedented amount of influence and control over our lives, it's getting harder to pry your life away from their claws.

Sadly, I think things need to get much worse before they get better. People still don't understand the dangers of it, though I believe this has already become a sociopolitical problem instead of just an annoyance.
> Obviously unlimited length can't be literal, if the Suez isn't perfectly straight, right?

It looks to me from the map like the tightest turns in the canal are the southern exit near Suez, and the turns between Timsah Lake and El Qantara el Sharqiya (depending on which channel you're in, and whether you're allowed to use both channels in your turning maneuvers).

It would be a fun problem to find a good way to figure this out exactly, but it looks to me like a ship 3000 to 4000 meters long would not be able to complete those turns even in principle without running aground. (Presumably the actual practical limit is a lot lower.)

The longest ship ever built (which exceeded the draft limits for Suezmax, so it was out for a different reason) was 458 meters long

https://en.wikipedia.org/wiki/Seawise_Giant

... so there might still be an order of magnitude to play with if you were making a ship that was ideally small and maneuverable in other regards.
I have always been curious: is it any cheaper to set up shop in Canada than in the US in total cost? The wages are a fair bit lower in Canada but I wonder if corporate taxes offset these savings.
I fear the pandemic has crushed hang out culture for the foreseeable future. Out here in the Midwest, I grew up hanging out on the back porch is talking late into the night. People don’t do that anymore it seems.
I'm the opposite, I despise anything angular, vue, knockout, that makes devs learn a new language.

React just uses js, almost plain.