skysight-inc/HackerNews huggingface dataset:
Summarizing, it looks like the TMPRSS2 protein is necessary for the virus to replicate, and the Androgen Receptor modulates its transcription.

But where I'm confused is why this drug in particular was studied, instead of an approved AR antagonist like bicalutamide or enzalutamide. Way easier to dispense those than some clinical trial drug, right? And is it important that the drug is a silent antagonist of AR rather than an inverse agonist?

Also, how does this affect women? Are we at less risk of mortality through this mechanism? My T levels are very low, but all of us have androgens and their receptors. Maybe TMPRSS2 gets transcribed even when T or DHT levels are low?
Digression: for all authors that want minimalistic website, please don’t push it too hard, as author of this website did. Color scheme is nice, as is font selection, but it lacks navigation links. Putting simple link to website home would do so much for explorers of site.
"My fellow Americans, I'm pleased to tell you today that I've signed legislation that will outlaw Russia forever. We begin bombing in five minutes."

Who needs Twitter when you have TV?
> If the industry they work in can't compete their entire income is reduced to zero.

But I thought we're talking about a time period before that industry even exists.
The source ports of the engines seem to be GPL'd though, so I'd imagine an indie dev would have to open source their game as well?
Uh, that code looks a lot like PostScript.

Call me crazy, but you would write a Z-Machine on that.
whats the lag?
It is virtually impossible to not offend anyone, so they choose from the basket of all potential customers or products which they believe will be most profitable. If the ~~nazis~~ alt-right were making them more money than centrists and leftists, they wouldn't have banned them by citing freedom of speech and expression. However, their analysts probably deemed that losing the rest of the user base through the #cancel culture isn't worth it.
Talented people are in DC for the jobs, not the other way around.

If my wife's job got moved to a more affordable place, I'd love to leave.
Cardano (ADA) is now available on Coinbase
Meh Gerard Villiers is the guy you wanna be reading for all the real juicy.
Yes, more on point for creative business application is Roger Von Oech's Whack Pack series of card decks. Get them at Amazon or wherever.
I do my best to not change defaults on systems that I use. It ends up being a pain point any time I go to some other computer and have to deal with my extensions/customizations not being there. Something needs to be a big productivity gain to merit the change (or else be a trivial modification, like disabling caps lock).
exchanges charge for access to this data. standard data providers are Bloomberg, Redline, and then the execution shops sell their own products too.
I built a shopify app for my ecommerce monitoring system and my system is mostly written in PHP I have some Go and Python for various stuff by the core is in PHP mainly because I think PHP is really good language for web apps, it's designed for it, literally. I went to use the Shopify php library and it's literally dead, I looked at the issues and there was a Shopify employee advising people to use an unoffical one that basically supports everything. It's cool the employee pointed people in the right direction but I think it's a sad state of affairs that one of the most popular web programming languages in the word has no support from them.

Also, the reason people can't use Shopify with my system yet is that even to be approved for an unlisited application you need to allow for account creation via Shopify. I understand for listed apps in the store but if I want to have an app where they click a button on my site and I connect to their shopify system and get data I still need to support this feature I won't use. That saddened me. I just need to create time to allow for account creation via their app store and figure out what that means getting the info and how to handle user confirmation if at all.

(Shameless plug - https://www.ootliers.com)
Is there any basis in fact to what's alleged in the article? Forking over your university login credentials to scihub seems like a very bad idea indeed. OTOH, presumably they must have amassed almost the entire corpus (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5832410/) by some such means...
I'm sure a lot of the companies who might have benefitted from abusing it were persuaded to wait by various public pressure campaigns. It's always easier to push stuff in slowly once attention was elsewhere.
This article is giving me a major case of Gell-Mann Amnesia.

The writing follows no thread, the article contains no more information than interleaving parts of two press releases would give you, it's a complete mess. This would not pass for a decent writing assignment at the high-school level — and yet it's published by the BBC somehow. Even the subheadings are weirdly chosen.

Was this even touched by a human?
That's a lot of extra keywords.
I would like more data for [1], with a breakdown per gender of each category and size. The data they show could be under the effect of a Simpsons paradox from the way they present it.
The PI is needed for bridging our PCM3060 based custom sound card(via hardware i2s) with a WebRTC client that connects to the customer. It also handles all the high end internet connectivity and allows us to easily flash the microcontrollers with new software. It could have been done with audiointerfaces instead, but this approach is truly modular and allows us to scale it easily.
TLDR:

> when you log in with an incorrect password, Zoom will lock your account for a set amount of time.
The more times you do this, the longer the wait period for you to get back into Zoom. She also noticed that the error that is presented to a user when they are locked is “Incorrect password” and not “your account has been locked”
I have never heard of this. Link? How does it do for French-English?
Even if you are right to be 100% confident others may have phobia of dogs (possibly due to traumatic events in their past) or simply can't tell at a glance how well trained your dog is so you should still use a leash in close proximity to others.
That argument proves too much, I think. It seems analogous to the question of "Why would anyone ever want higher taxes? If they think the optimal tax rate is higher, they can just pay more taxes."

If one company takes a more principled approach to moderation, and that more principled approach is harmful to revenue, that company will be outcompeted by companies with whatever moderation policies optimize for engagement / revenue / growth. As a result, in the absence of legislation, you get adverse selection i.e. the dominant platforms will be the ones that optimize for engagement/revenue/growth, rather than the ones with good moderation policies.

If you instead have legislation for what "good moderation" looks like, it applies equally to all companies and mitigates the adverse selection problem.

Of course, it is still entirely possible for bad legislation to introduce worse problems than the adverse selection problem. It depends on the object level of what exactly the legislation is, rather than being a blanket "legislation bad" or "legislation good" sort of thing.
I think they do use "donated" credentials in the background, but the article makes it sound like people would be phished into handing over their logins, which is not the case at all.
Yes, this is really the only way to tolerate Docker on a Mac. Basically it's the same thing WSL does on Windows. Linux in a VM then you run Docker in the VM. Not many people talk about doing it this way though.
Thirty km is far enough to build a far more secure capitol, with defensible street design, and large clear zones for tank maneuvering.
Sure, you can email me at usama@inventhub.io
Next-gen SpaceX Super Heavy rocket shown off in Elon Musk tweet
Who is this mythical person jumping between tons of computers? Who is dependent? The few times you're on a different computer you just deal and fallback to the mean.
My SIL complained that her 13 year old kid managed to disable Net Nanny on their home computer.

That is why I never bothered with internet filters or domain blocking @ home except for pi-hole to get rid of the worst ad's.
Dennis Ritchie on alias analysis in C (1988)
I tried to record one, and after it was done it seems order was messed up - some steps from beginning were pushed to the end. Not sure if I can reproduce, but thought you might find it useful to know.
After all Quake was the demo tech wow factor for your spoiled friend and his 3dfx :)

Yeah Duke3d was running fine on any computer and most of all, it was FUN, both as a single and multiplayer game.

The map editor was amazing. I remember using all the tricks highlighted in this Twitter thread, following tutorials from PC magazines and having the docs printed in a folder I may still have somewhere... You could also quite easily break your maps with too much trickery.
I do prefer precision in my humor, yes.

Seriously though, I find the entire period fascinating (mostly via the Revolutions postcast, and reading Hilary Mantel's A Place of Greater Safety). The French Revolution is such a pivotal point in Western history that I believe that precision is important.
How do you solve deepfakes with asymmetric cryptography, without just trusting the person the videos purport to be of to say (cryptographically) whether something is real or not (which is not a good solution)?
I don't know how sci-hub works but there have been private versions of it for decades and that's how they worked, but that always occured in somewhat trusted circles.
No surprise.

Any lockdown advocates after a month or two of the policy have willfully made the decision that sacrificing the well-being of children is worth protecting the vulnerable.

How do you teach someone to read with a mask on? You'd think the "pro-science" side would understand the deep evolutionary roots and development of social creatures.

You don't just stop this, it's indispensable. And given the evidence so far, absurd that it's treated as dangerous.

It's unconscionable that those least threatened by the virus are abused with such little thought.
I think most people understand chromosomes are too small to see.

People who menstruate is more accurate.
There's no reason to believe qualia arise in a given discrete computation. Why would they? In what steps in the algorithm do qualia arise and why, what characteristics do they have, what causal roles do they play, etc.

It's completely self-evident we experience qualia. It's what our experiences are made of. There wouldn't be anything to experience or discuss if we didn't. The brain is not a deliberate, man-made object like a computer is, hence why it can possess these properties with us being unaware of how (they were selected for via evolution), but the computer cannot.
This has been BBC News style for a while.

Very short paragraphs in a semi-random order, together with a smattering of out of place headings. I assume they must have some internal style document, because it applies to a good chunk of their stories on diverse topics.

"The occasional quote which is unsourced, and doesn't have an end quotation mark.

Questions have been asked

Not unlike this comment really.
continue until retirement
My PhD research was funded by public money. The work was nothing special (that's putting it mildly), and it was a couple of decades ago, but thanks to it I ended up as a co-author on two peer-reviewed papers. It seems beyond crazy that there appears to be no legitimate way for me to share my work with others.

The quote from Max Bruce, the City of London Police's cyber protection officer that "Sci-Hub will then use [stolen credentials] to compromise your university's computer network in order to steal research papers" shows some fairly serious misunderstandings of how scientific research is funded, carried out, written up, shared, and published ... and which multinationals get rich from selling access to the very last bit.
Genius. I know HN comments should have more substance, but what else can I say.
Do people really need a tool to do this? This is tech sales 101. Everyone does this.
Hong Kong companies have better brand reputations than Chinese companies but gradually there are more Chinese brands gaining better reputations.

I would expect this to continue. In fact, there are probably a few brands that are Chinese that you don’t realize are Chinese.
If having a specific version of a tool is important for your work, it’s probably best to install that tool separate from homebrew and manage that install separately. The Postgres docs seem to recommend the EDB installer.

https://www.postgresql.org/download/macosx/

Likewise Python and other programming tools where running a specific version is important are best managed outside homebrew.
In Denmark, you rarely ever ser a pure Visa card, it’s almost always a “visa/dankort” where the second part is the danish national debit card. It’s just a natural part of the cards and most refer to all credit/debit cards a “dankort”.
I was under the impression that DMARC always requires DIIM.

One unanswered question: should the mailing list software rewrite Return-Path? (to detect bounces) wouldn't that trip DKIM alignment?
> male influencers are paid almost 100% more

This isn't entirely surprising. They're much more rare so there is lot more competition for their services, piled on top of the usual biases in our society against paying women equally.
This looks fascinating, but I would imagine cost will either be high, or there won't be enough IP addresses. I have a friend who runs a small ISP and IP addresses are not cheap. To have one per device for most people will take a lot of IPs wouldn't it?

I'm intrigued though. I just got my Starlink dish and am about to set it up, and Starlink doesn't offer static IPs (everything is CGNATed). I'm spoiled right now with my static IP.
This can be done using xbar, trivially.
The input system is discrete but the end-result, our conscious experience of our world-simulations (made up of visual qualia) are not discrete. They are unified.

An example of how this could be implemented (not saying this is the case, just one of several possibilities):

https://en.wikipedia.org/wiki/Electromagnetic_theories_of_co...
I didn't know this was happening. So I went to Google Maps and checked it out, and it is a huge project.

I understand how Dubai and similar places get to expand so quickly, but this does not make much sense for Egypt.

Looking at what is being built, it starts to look familiar: huge city sectors which are multiplied in layout and construction style, a massive "design part of city once and reuse multiple times" like it so often is happening in China.

https://www.google.com/search?q=china+egypt+new+capital then yields the answer.
> It does seem to be true that countries which experienced the SARS epidemic first-hand developed what we might call institutional antibodies, and were quick to impose various controls (especially contact tracing) which were more effective at controlling COVID-19.

Ironically in some ways it had the opposite effect in Canada. We remembered how hard-hit Toronto's tourism industry was as a result of travel advisories from SARS-1 and so were initially supportive of China+WHO's argument against banning travel. But like you said, it's really hard to see this not being a pandemic either way, it might've just bought a bit of valuable time.
I remember learning that Build didn't support structures on top of other structures. You could go up a staircase, but you couldn't end up on top of other level geometry. The level design in that game was so good I never noticed, and would have sworn it wasn't true.
Yep. If you don’t have an on premises solution for those industries, you end up making or using an industry specific cloud (see Microsoft, Amazon, and others serving cloud solutions for DOD where there’s enough money to force this).
Police warn students to avoid science website
Type elision or similar is available in many statically typed languages, and has been for a long while.
Guess you can download some non-official science views from Sci-Hub.
For those like me who missed it there is a "Next" button that takes you to the subsequent pages of the article.
What are we supposed to understand ?
Where is

or

Whereas
For what do you spend the 30M difference between arr and profit?
It is a typical retort to anyone criticizing Egypt's first Tahrir Square government that they are representative of "the West and Israel", when in fact the notion that there exist certain universal human rights that any state is bound to respect, is upheld even in many countries outside of the West and Israel.
Amazing! God Tier! I love it and thanks for the articles to go with it!
> The Rust Evangelism Strike Force could take a few hints from the actual military about how to design a language to a spec.

You can argue that Rust could do better, but using the military as an example of doing it "right" is kinda funny.

1) The military changes specifications all the time, which is a big reason why so many projects go over budget by 300%. Look at the B-1, B-2, F-22, F-35, Space Shuttle, etc. All boondoggles caused by making tons of last minute changes that blow up the entire project.

2) The military is moving away from Ada. The F-35 avionics code was all written in C++. Apparently they decided it was easier to hire existing C++ developers than to teach people Ada.
Does Sci-Hub work any more? The popular links lead to citationsy dot com, which is not Sci-Hub.
> Women charge an average of $351 while Men charge $459.[1]

That's 31% more, not almost 100% more.
> "Though women make up 77% of the influencer market, male influencers are paid almost 100% more. " [1]

But thats how suply-and-demand workforce always work doesn't it? Too much people doing the same job tends to lower the wage for that job; and because a lot of companies compite for different markets when sponsoring a male influencers vs female influencers (e.g. "this is the shaving cream I use" vs "this is the bra's brand I use") they are income-wise 2 different jobs.
FlashFXP
There's a lot of motorcycle geeking in that twitter account, e.g. https://twitter.com/azusagakuyuki/status/1365132939135127552
It may be close to Cairo but it has massive walls with tower like structures. The walls look rather like Trump's wall prototypes. Without knowing about it I drove past it on a bus the other week and was think that the hell is that thing? It looks a bit like a huge military base but grander. The entrance gates are quite something, about the size of 10 story buildings.

Pic I took from the bus, assuming it's the right thing https://imgur.com/bb5KE9Y

It looks surrounded by open ground and looks made with security in mind.
The parallels with the current state in India are striking.
> The fundamental issue is that Python doesn't really have a way to enforce this

When (as to make this even worth discussing, one must) one includes the typecheckers (which are technically external) in “Python”, that's not true; both mypy and pyright enforce that abstract classes (either those explicitly declared as abcs, or derived classes with any non-overridden declared-as-abstract methods) cannot be instantiated.
Amman is the largest city in Jordan by some distance _now_, but when it was designated as the capital in 1921, it was much smaller. Its growth has come almost exclusively since then, and as a result of its designation as the captial, it became the largest city in the country.
TE people advocate policies that create those outcomes. I've seen none support creation of separate but equal facilities for trans people. It's too costly for such a small minority they say.

Rowling hasn't been censored.

Cis women and trans women are in the category of women.
The S in IoT is for Security
GPL2 has no explicit patent grant, and Oracle's behavior does not signal good intentions.
Check Wikipedia for an up-to-date link.
Which ones may I ask? I’ve been shocked to learn how many online EHR/EMRs work... it’s a bit frightening to think it would be trivial to find large densities of ailments / preconditions to exploit at a state level.
AI and Drug Discovery: Attacking the Right Problems
For the uninitiated, can someone provide some background reading on why Linus calls the 286 "truly disgusting CPU architecture"?
If a university wants the work to count towards the targets it is measured by by government, or if it receives certain types of public funding (which is pretty much most of it), there's an expectation in the UK for it to be open access within agreed timescales. If it's not, then it can't be counted for the key reporting metrics.

The end result is that the vast majority (i.e. almost all) such research (regardless of how funded) is public and accessible on the institution's repository, or otherwise deposited with an open access library, such that it can "count" towards the metrics.

A clever approach if you ask me - find what matters to the individuals concerned (the metrics), and discount work from those metrics unless made freely available within X days, with appropriate audit trail to match.
Educating others, communicating events, and discussing these cultural touchstones is the beginning of the end for such things. It's a process (I think), and we're all collectively part of it. The end of this particular cycle may not have a definitive date though.

I want to stress that honest and open communication about opinions and a commitment to truth and the long process of fact-checking seems to be the best way forward, if not necessarily the easiest.
Its taken us 400+ years to get to this point. The science was in on smoking in 1948. It has taken over 70 years to get what progress we have had. That's a lot of lives cut short and a lot of suffering.
> Is there a project somewhere that packages these options into a GUI?

There was: Secrets* was both a website were people aggregated a small database of these options and a MacOS preference pane which displayed these:

https://web.archive.org/web/20150515104503/http://secrets.bl...

https://blog.taylormcgann.com/wp-content/uploads/2012/03/sec...

(* by the makers of Quicksilver!)

Sadly the project stopped updating in 2012 and the website, repository and forks seem all long gone.

(Should anyone resurrect this great app, one improvement should be versioning of secrets recipes. AFAIR Secrets.prefPane displayed options long after they stopped applicable for later Mac OS versions.)
I think OP is talking about access to the COVID vaccines. As much a human right as access to cocoa really.
Wow I’d forgotten all about hacking rules.ini! That and hacking around with QuakeC and Quake level editors are fond memories of the earlier days of gaming :)
I don't want to live in a trustless society. What you describe sounds like a totalitarian dystopia to me.

I want escape hatches. I want plausible deniability. Facts in a vacuum are useless and can be used to propel all sorts of narratives. Facts without framing and contextualization aren't worth much. You can manipulate easily without technically lying, just by cherry picking facts that suit your agenda.

You need some amount of trust and solidarity if you want to live in a healthy society.
That's not how color-blindness works.

In classic deuteranomaly the red and green cone peak sensitivities are closer together so red and green light are perceived similarly.

The red cones aren't gone and in low light you aren't even using your cones, you're using your more sensitive rods. Rods are inherently color-blind in all of us.

What is useful about a red light is that it has very little blue. Blue light is what causes the iris to contract.

So the ideal night lighting would be a brightish mix of red and green to give the rods lots of light to see with almost no blue in it to stimulate the blue cones and cause the eyes to contract...

Oh hey! That's what the yellow color of sodium lighting does if there aren't a bunch of stupid SUVs with bright white projector lamps all over the road.

Fancy that.
Why don't the brew developers change this/add an option/make it opt in?