skysight-inc/HackerNews huggingface dataset:
You still need the phase I trial to determine that it is somewhat safe, the phase II trial to determine that it is somewhat effective for some people, and the phase III trial to see if it is safe and effective on a large diverse population and to characterize side effects.

If you were dealing with a disease that is rare so that it might take a long time for enough people in phase II or III to get exposed to it naturally, an HCT might be able to cut the amount of time you need for phase II and maybe phase III.

With COVID, there should be enough people getting exposed naturally to make that unnecessary in phase III and probably in phase II.

What an HCT might do for a COVID vaccine is let you figure out early that your vaccine does not work. That might let you abandon an ineffective vaccine during phase II instead of not finding out it doesn't work until after you have spent a lot of time and money on phase III.
Map of US Volcano Hazards by Status
Wrong. History's written by whoever happen to write anything and then interpreted by future generations, whether that's historians or not.

The confederate are losers, and yet folks after the confederates were able to erect statues commemorating their losses.

It also help create a false notion that only history written by winners create the narrative that everyone accepted.
Given that it's infused with epoxy, as they say, I imagine it would last a long time, and I don't think it would be susceptible to insect damage.
"... This means Microsoft has access to every updated Pi computer running Raspberry Pi OS with rights to install any package, run any program, or edit any file without prompting the user. A lesser issue that has bothered some users is that on every run of apt update, the Raspbery Pi will send a request to packages.microsoft.com and thereby reveals the IP address for potential use in tracking or marketing efforts. "

https://en.wikipedia.org/wiki/Raspberry_Pi_OS#Microsoft_Repo...
I set up FreeBSD on my rpi 4 a while back and had to jump through some hoops to get it to recognize all the RAM available; [1] anyone know if this version will do that out of the box?

[1]: https://lambdaland.org/posts/2020-12-23_freebsd_rpi4/
Ah HN. Where else can I read about someone abusing an infant with nostalgia, while also suggesting that it’s a failing of western culture to not beat ones children.
No. The white wood has rough surfaces which make them opaque. Filling the gaps with epoxy effectively removes that roughness.

Not sure how they "infuse" it. That sounds like driving it deeper.

Years ago we had an opaque SLA prototype part. I came in the next day and it was mostly transparent. The M.E. told me they painted it clear...
Does safety glass not already make breaking cleaner and quieter?
So, defensive language aside, I think that the FDA has a point in its white paper. The reason we don’t have cures for a lot of diseases is not so much that pesky regulations keep great drugs from getting to the market. It’s that we don’t know enough – yep, even in 2015 – to make so many great drugs.

https://blogs.sciencemag.org/pipeline/archives/2015/08/07/on...

Now, when I mentioned that we’d surely have killed off more people by doing drug research by the more direct routes, the reply is that we’ve been killing people off by moving too slowly as well. That’s a valid argument. But under the current system, we choose to have people die passively, through mechanisms of disease that are already operating, while under the full-speed-ahead approaches, we might lower that number by instead killing off some others in a more active manner. It’s typically human of us to choose the former strategy. The big questions are how many people would die in each category as we moved up and down the range between the two extremes, and what level of each casualty count we’d find “acceptable”.

So while it’s not crazy to say that we should be less risk-averse, I think it is silly to say that the FDA is the only (or even main) thing holding us back. I think that this has a tendency to bring on both unnecessary anger directed at the agency, and raise unfulfillable hopes in regards to what the industry can do in the near term. Neither of those seem useful to me.

https://blogs.sciencemag.org/pipeline/archives/2013/08/19/is...

The replies to my comment here nicely delimit the cleft stick the FDA is in. You are on the "oh, god, just let them try it already! the FDA are stick in the mud beancounters just holding everyone back" side.

A few others are on the "But this one time, they didn't pull Vioxx fast enough, and look at what it got us!!" side.

For myself, I'm glad that 1. i don't have to walk that tightrope and 2. there are enough people to make an institution old enough to have memory that _do_ walk that tightrope.

But i'm pretty sure that sanity is somewhere in the middle, case by case, agonizingly slow clinical trial by agonizingly slow clinical trial.
This is wood soaked in epoxy. The epoxy should provide plenty of protection (note that lots of houses are made of regular wood, so I don't think this is much of a problem anyway).
Better argument against “Real Names”:

https://geekfeminism.wikia.org/wiki/Who_is_harmed_by_a_%22Re...
Everyone also seems to have forgotten "flatten the curve" etc.. It's like we have collective amnesia.
The creator of supercookie.me made it sound like all versions of FireFox were vulnerable.
Please recognize that the caution around new food science advances is based in experience. I’m sure most of us are old enough to remember when most crunchy fried snacks were on the shelf with oils that had no known health risk but turned out to produce widespread uncontrollable diarrhea because the oils were indigestible.

I’m not suggesting these new meat substitutes have that effect but it’s reasonable for people to be cautious. Yeah heart disease and global emissions but... also soiling yourself without warning in public.

The best thing proponents of these new foods could do is genuinely and honestly recognize and address those worries.
This is at best dishonest, if you really referred to that definition, you would use "meat", not "imitation meat"/"fake meat"/"plant based meat". Everything in the marketing of that stuff is made to mimic meat-as-in-animal-muscle meat.

If you want a burger, go eat a freaking slaughtered cow patty burger, don't be all fancy with that highly process crap.
Why?

https://en.wikipedia.org/wiki/Tintagel#Toponymy doesn't even mention that as a theory.
+1000 I've been trying to do this (split into sections and eliminate umms) with recordings of live classes... it takes me 4 hours per each hour of recording.

if you can make this process faster the world will throw money at your feet.. at least I will
Elastic didn't relicense Elasticsearch. It forked it
I thought of ADRs too, but it seems the objective here is to be a bit more high level. It doesn’t help that the term “architecture” is so wide in meaning.

I’ve adopted ADRs and it has been good for decision making, but it doesn’t help much new contributors to find exactly what module they need to focus on for a task.
If physicists at large say "that's not how science is done" that renders the work which went into it non-existant and turns it into "mundane information about his life"? No, clearly it doesn't.
I downvoted because off topic personal issues
I’d be fine with that and then plant-based pub burgers for the rest.
I was curious so dug a little. A quick google surprisingly doesn’t really turn up reliable looking sources, but it seems like the answer is no. Most likely either Cornish or Norman French in origin, unrelated to German-derived “tin”.
Considering that there’s no consistent definition of what is meant by mediocre programmers vs “good”, “really good” etc, I get the feeling that this isn’t a very productive approach to measuring the skill of programming. As the responses to your comment demonstrate, it’s hard to get a common definition and thus I feel this discussion to be fairly pointless.

I will say this though: there is nothing magic about programming, or really any technical skills like it. It’s all about practice and getting better with time. I do sincerely believe that anyone can be a productive programmer that delivers within the constraints that are demanded of them.

If you’re talking about “prodigies” or “polymath” or people that have certain conditions that allow them to be more productive without the same amount of effort, yes, I do agree such people exist. And they exist in every field. I don’t think they should be what most programmers should try to emulate though.
PC/MS DOS of course. It was the last OS I could hold in my head. I could understand every part of the OS. I could write everything from batch files to TSR's. You could reason about every part of it. Did that make it perfect? No not at all but it made it my favorite for a very long time.
Why C and C++ are awful for teaching programming languages (2010)
Tesla's Founders on Elon Musk and the Early Days [video]
> About me. I am a twenty year old student from 🇩🇪 Germany

Impressive! Come work with me :) can’t wait to see what you do by the time you’re 30.
whoah! I had no idea transatlantic Saharan dust was a thing, let alone that it delivers phosphorous to things growing in South America!
> Not sure how they "infuse" it. That sounds like driving it deeper.

NileRed did a video about preparing this from a different paper: https://www.youtube.com/watch?v=x1H-323d838

It seems that you just soak the thing in epoxy in a vacuum. The results were not great, though.
Hackers briefly took over Google.Lk domain
Say it with me, America is not a global bully. Now say it in a mirror a bunch until you believe yourself or you realize how it is bullshit.
It's very simple.

As a parent, your job is to help your children become the best people they can be, not the people they'd turn out by default.

I would much rather my son hate me now and thank me later than the other way around.

To use this example - if your choice is to raise a child who is organized vs one who is a slob: aim for organized because it will help them down the road in many ways. It's not the most important thing, but leaving the kid to their own devices is just lazy.

Funny example - every woman I ever dated has a story of coming to a guy's apartment, seeing that it's gross, and turning around. So these men are literally missing out on sex/partnership opportunities because their parents didn't teach them to clean up their room. Thanks a lot mom and dad.
Actually there is a shortage of glass-grade silica.
https://www.bbc.com/future/article/20191108-why-the-world-is...
Have you considered that maybe it’s just you/your family?
Still, it would be better to use the existing RP record type (with included additional TXT link) than to make up YET ANOTHER overloading of TXT.
Modern engine should meet California emissions. It might require a modern engine control computer and all that jazz; which may be less serviceable but whatever. I'd take a modern computer controlled fuel injected what not over my old carburated v8 that was easy to adjust, but needed adjustment all the time. Just starts every time for me thanks.

But, ignoring engine adjustments, what I'd love in a car is things like using the most common lights; and making the lights easy to access. Because changing the lights is a normal and necessary thing to do.

Don't make it take 30-45 minutes to change the (12V) battery, because changing the battery when it dies is a normal and necessary thing to do.

Basically, design around ease of maintenance, more than making it look cool and hip. I'm not necessarily going to do all the maintenance, but if important things are easier to get to, it saves me money, because it saves my service shop time.

I'd love it if it wasn't 2 cm off the ground, so you could get under it to change the oil; but I'm not going to win that, because I'm exaggerating a bit, but low clearance helps fuel efficiency, and fuel efficiency is required. I'd also love less of the under body panels to help with airflow that get banged up and then fall off or drag and cause terrible noise.
You get the other benefits of cryptocurrencies: direct control and the ability to store or send it online with no middlemen or custodial risk.
As long as there aren't enough great programmers in the world to satisfy all programming needs we will need mediocre programmers to cover for them. Programming isn't a competition and hence it doesn't matter if others are much better, all that matters is that there is a need for what you can provide.
Yeah, 23andme uses a DNA microarray to genotype your sample whether it be for health screening or ancestry. It's cheap technology today.
Cannot resist responding to this :)
VAX/VMS, of course.
What other O/S has anything remotely like SYS$QIO, Event Flags and ASTs?
> note that lots of houses are made of regular wood

Yes, but that's why in certain areas you need to do termite inspections because the treated wood doesn't provide 100% protection. Also the wooden parts are normally protected by other materials to not be exposed to rain and rot - in this one the epoxy layer would likely do that, but still, it depends on good coverage/protection.
It's terribly sad how prone people are to creating their own personal echo chamber once given the tools to do so.
There are like 50+ COVID vaccines in development. Which one do you administer? Forget about side effects, half of them are probably duds! Can we afford to administer billions of vaccines that don’t even work?
any other games that you've played on them that you care to comment on performance wise? just curious
Electric cars may change the future of the Australian service station
It's a CFD with a constant interest payment. I find it hard to believe that similar didn't exist in the wild days of bucketshop trading in the US.

Without one or something substantially similar why would you ever exit a losing position? :)
What is a historical example of a country with a mechanism for "temporary authoritarianism" where that mechanism was not abused to create permanent authoritarianism?
I'm not going to dismiss it outright, but I am mild-to-medium skeptical of this theory. Take a look at some of the recent years of subsidies listed on https://farm.ewg.org/region.php?fips=00000&progcode=total&yr.... It's not just that we prioritize feed crops more than oranges, we also prioritize feed crops more than potatoes and root vegetables. Our corn subsidies are on average over twice as high as our wheat subsidies, and over 7 times as high as rice subsidies.

Even dairy consistently gets more subsidies than fruits and vegetables. Are we really just optimizing for a worst case scenario where we literally run out of food? Does it really make sense for us to say that during a famine or a drought that milk will be an efficient use of resources? Nobody is baking bread with canola seeds, is it really more important during a famine that we have canola oil than potatoes?

Maybe this is the result of a highly researched government program about how to survive a worldwide famine. But the numbers I'm seeing aren't doing a lot to convince me that famine planning is a more likely cause than lobbying.
It's a stupid comparison, because keeping your stuff organized is an important life skill while choice of desktop wallpaper is irrelevant.

Well, I guess if your desktop wallpaper was porn or nazi paraphernalia your parents would be totally right to teach you that it should be something else.

Frankly your posts read like someone who doesn't understand that as an adult, it's your responsibility to have more wisdom and experience than your kids, and to help them benefit from it.
Yes, my first thought was what are they using for the fat? Whey protein doesn’t seem that useful for cheese, since that’s the part of the milk most cheeses don’t use.
Heads up to anyone wanting to go through this book and use the code samples: they're all in Python 2.

Don't let it deter you though, it's a fantastic book.
Even better, a technical argument: http://habitatchronicles.com/2017/05/what-are-capabilities/
In my experience, how they're prepared matters a lot. Strangely, I think Impossible Burgers (the ones I'm more familiar with) do worse when they're overcooked than actual meat does. The very first Impossible Burger I ever had was thick and cooked medium-rare, and it was terrific, pink on the inside and genuinely juicy. If I didn't know it was plant-based meat, I wouldn't have been able to tell you; it didn't taste quite like beef, but I might have guessed there was a little sausage or something else mixed in there. When I've had Impossible Burgers cooked fully through so they're more medium-well or above, though, the pea/grain flavor starts amping up quickly.
I can’t stress how important it is for parents to build really strong communication skills. Young kids, and especially teenager, are experts at divide and conquer. If parents are not presenting a united front, stress and parents fighting often follows. We never countermand one another in front of the children. Ever. Any time kids ask for something or want something it’s always “what did your mother/father” say first. If they mislead or lie about their answer to that question it’s on them and the consequences are much heavier for them. It’s a simple system but it takes a lot of trust and patience with your spouse.
>> my house, my rules” is not a convincing argument

>> It is in my house ;)

Just wanted to tell you - I laughed out loud. Dad power! (Or mom-power, whatever)
Yes, in hindsight with our computer-centric perspective today, it seems like programming the MC14500 is something you'd get CS and programming people to do.

But the user manual has sections on how to translate ladder logic and similar control logic into a program counter circuit and appropriate code, step by step. If someone was familiar with industrial control and basic digital electronics, I think the manual is about all they would need. The same can't be said for most other microcontrollers which are indisputably full computers, with all of their complexity.
I'd argue using the 18th century French right/left dichotomy isn't a mental model with meaningful predictive power, and the real forces at play today only leverage people wasting time re-litigating positions based on them.

The war isn't on dissent, dissent is only an early skirmish. Like previous ones, perhaps we will only be able to piece it together in hindsight.
Statistical terms: what they mean
Here's another recent resource: https://www.gormanalysis.com/blog/python-pandas-for-your-gra...
Read it again. You have to tell Tesla where you are going or it won’t go there. This is just the next step in their autonomous driving plan.
A side issue, but I think it may be just cause to wonder who the victors of that conflict actually were in the end... turns out, it may have been 'white people' generally on 'both sides', after a brief period of "reconstruction" that could have ended differently but didn't. All those statues were erected after that period -- indeed they do look kind of like victory statues, curious isn't it? Who won what before erecting those statues, hmm?

The proverb of course isn't literally always true, it isn't only "the victors" who write history. But the powerful do have a disproportionate (but not exclusive) influence on what gets remembered how (what gets remembered how is a factor of both what historical record is left and who can advance their interpretation of it). The victors tend to be more powerful than the vanquished, if they don't appear to be then there might be some confusion over who won what exactly.
If you train a developer, educate them about good practices, reward responsible behavior and engineering rigor, and amplify their impact giving them good infrastructure and tools, it is hard for that engineer to stay mediocre.

If you show developers thay you do not care about how they do things, they will become mediocre. Unless they are ethical and do it anyways.
I’ll warn that the two big perf claimants (esbuild and SWC) have absolutely barfed on perfectly legal syntax in a project I contribute to. SWC didn’t even say what the problem was, esbuild complained about spreading props into a JSX expression even where other props were being spread into other JSX expressions in the same module. I’m not disparaging either effort but they have some rough edges.
> Apparently the US views the solution to this loophole as arresting the founders of Bitmex, regardless of their country of residence

The only person who's been arrested (Sam Reed) was arrested at his home in the United States.

Arthur Hayes, the main focus of this story, is a US citizen and spent most of his life in the US, though seemingly has lived in various countries of late. By virtue of being a billionaire, he can most likely reside whereever he likes. I cant see why that should make him immune from prosecution in the US (a Grand Jury found there was enough evidence to indict him, though this does not mean hes been found guilty of anything).
It is hard to compare efficacy between different vaccines trials sinc each one was tested in different populations.

For instance, Sinovac vaccine was tested in hospital workers in Brazil. This population is more exposed to the virus and have access to tools that can break the blindness - some people did and posted on social media celebrating.

There was no death from covid in the vaccinated population.
> I've seen many possible explanations mentioned. Most common seems to be that raising daughters is more stressful than raising sons (for various reasons)

My mother specifically stated that she always intended to leave my father after she had a daughter. The custody hearing was basically "I want the daughter, you keep the house kthxbye". I have a feeling that this is not a special case.
On Firefox Focus Android 8.12.0, the demo gets stuck in an infinite loop.
An extra point to add to this: Bitmex isn't an exchange and never touched USD or any other fiat currency, you couldn't obviously use it to launder money (at least not in any way that you couldn't use any other custodial wallet to do so).

Essentially it is just a platform that lets non-US bitcoin users deposit bitcoin and place side bets on price of Bitcoin (and several altcoins, note that you couldn't deposit and withdraw those altcoins AFAIK, just place sidebets on their exchange rates).

It is easily (ab?)used as a gambling platform.

From a consumer protection perspective it's probably a disaster-- the vast majority of users lose their shirts. But I'm not aware of any accusation that there was widespread use by US persons. And CFD gambling houses are common in many places outside of the US.
Aluminium oxynitride or ALON, it is only slightly more expensive than ballistic glass.
My memory was telling me the examples were all in C, so I went just now and picked a few random chapters, and the examples I saw were in C.