skysight-inc/HackerNews huggingface dataset:
Phase III trials for both the Pfizer and Moderna vaccines actually began in late July, a mere 4 months after declaration of the pandemic. Challenge trials were unnecessary because they wouldn't have actually sped things up. By the time of the phase III trials you could already expect vaccinated individuals to be challenged via natural infection. And I'll bet money that the Pfizer and Moderna vaccines were, as a practical matter, given a green light by the FDA when the first early phase III results came back, months before formal approvals (which actually came in the middle of the phase III trials); meaning there would've been no regulatory risk to pushing the manufacturing pipeline into maximum overdrive.

There have been plenty of fumbles and mistakes all around, but I don't understand how people don't appreciate how incredibly fast the process has already been.

IMO, the real issues involve more mundane matters of logistics--coordination, resource allocation, etc. Could the process have gone faster? Probably. Not because of safety protocols or inflexible regulations, but because we had unforced errors starting and executing trials. For example, AFAICT, trials could have started in Brazil in early June, but presumably didn't because the companies needed more time to spin things up. And of course manufacturing and distribution of the vaccine should be going much smoother. Pharmaceutical companies and, especially, governments should have thrown more resources toward growing the supply chain of machinery; it was foreseeable from the beginning because of the manifest deficiencies in the supply chain for personal protection equipment, ventilators, etc, all of which made evident the need to retool industries to be able to scale manufacturing. And governments have had almost an entire year to figure out distribution protocols, but instead it seems officials across the board in the U.S. simply assumed it would be sufficient to push vaccines through existing healthcare networks, despite the fact they're notoriously byzantine and inefficient, especially for something so time critical, and especially given the need for consistency and uniformity across the population.

Is COVID-19 providing cautionary tales regarding government intervention in the free market? Absolutely. Not because governments have been intervening too much, but because they've been intervening too little; not because it has proven government more inept than private enterprise, but because private enterprise is intrinsically incapable of achieving alone the level of coordination needed to scale our response in the time required, yet we have shown ourselves too politically and fiscally risk averse to wield the tools of government in an emergency. It's like the delayed and anemic Katrina response, writ large.
Python Versions Management with Pyenv
Love the garden analogy in software, especially when faced with complex systems that can't easily be managed by rigid IT project management styles.

Was reminded of another short piece going way back to 2007: https://signalvnoise.com/posts/591-brainstorm-the-software-g...
In the 70s Monty Python picked up this tradition by shooting two episodes of 'Monty Python's Fliegender Zirkus' for German TV.

The first special was written in English, then translated to German, and all Python members learned their German lines by heart.
They didn't have time for the second special, so that one was dubbed.

https://en.wikipedia.org/wiki/Monty_Python%27s_Fliegender_Zi...

They're on YouTube with English subtitles: https://www.youtube.com/watch?v=uHs45_EQvO0
You're downvoted at this point but I think this is definitely going to happen in the future, even if it's just rewiring mouth movements to match the new audio.
Protein formation is well known to be involved in at least some long term memory formation and recall: https://en.wikipedia.org/wiki/De_novo_protein_synthesis_theo...

Although I'd again argue that there is no single "true" medium or mechanism of memory.

I'd remind you that DNA is indeed memory. It's memory whose recall is heavily modified and contextualized by its environment, for example methylation, the topology of how it is currently twisted, the kinds of nutrients available for molecular synthesis, etc.

If RNA mediates memory on a sub-generational timescale, it seems that it'd provide a dynamic, contextual bridge between generational memory in DNA and shorter term kinds of memories that play out over timescales less than an individual's life. So that the molecular formation of a given memory would have a semantic basis in the longer term context. A concrete but way oversimplified example of this might work:

You go through a traumatic experience where you almost die. The specific way you almost die is related to a number of factors involving your ability to run fast enough. The long term memories of that experience are then encoded as proteins by a mosaic of genes related to certain muscles, their shape and size, certain metabolic pathways, etc. The way we might unpack or interpret that memory at any given time/context could be as a gutteral impulse that results in such realizations as "I need to get more exercise" or "my grandparents had heart disease, maybe I should go to the doctor" or "wow I'm sure hungry for fish", etc.

Btw I'm not even arguing that it's as clear cut or simple as that, just sharing how I intuitively make sense of all this evidence and these hypotheses.
News: You must pay us to show our product.
Google: ok, then we won’t site them?
News: What?! Don’t show our product? Preposterous! Illegal!
I'm not going to split hairs about the actual positions of radical leftists, because it's not really relevant to this conversation.

I will, however, point out, that much of the alt-right is terrified of the antifa boogieman... And that Parler, the platform of free speech was quite happy to ban anything that smelled of antifa... As well as much that could, be described as moderate leftism.

Its tolerance for speech only extends to a very narrow slice of the political spectrum.
?

9 february is the date the short numbers are released for publication. Why would it be 29 january?

It's not a final date either, it's a date that more is known and people can act on that info.

You can always check the link I gave to see why... Since you obviously didn't.
Most professional Republicans didn’t actually agree with his views as candidate/president. Doesn’t matter. It was popular enough that they wouldn’t cross him. Voters... well, go look at the polls. The vast majority voting Republican did like or agree and were unwavering. Or go look at approval ratings and see he had a floor around 1/3 of the population. Roughly one in three people in the US was racist and hateful enough to hold an electorally decisive minority of the country hostage for one presidential cycle and threaten one more.
SEC Hunts for Fraud in Social-Media Posts Hyping GameStop
> Chrome will never: ban 3rd party cookies

It will ban 3rd party cookies the moment Google decides it's time to kill off most of their competition. They have Chrome installed on most people's computers and smartphones so they hold tremendous power to dictate the direction of the web, while they keep tracking people through the browser, with a user login, basically cookie-less.
I guess part of what I am saying is that when I was younger I gained value from scifi with a wide range of 'hardness' without knowing the physics, and even now, that I've come to understand the physics, I still find value in the same.

But I've found the more I know about something the more I know about all the stuff I have yet to know.

https://en.wikipedia.org/wiki/List_of_unsolved_problems_in_p...

https://en.wikipedia.org/wiki/List_of_unsolved_problems_in_m...

I feel the 'protomolecule' plays pretty well within these "plausible bounds" of uknown physics.

I think it's a fine metric but how or where you apply the function is subjective.

There is potential for issues even taking this route though.

There is an episode of Star Trek: The Next Generation where Picard is musing on Fermat's Last Theorem; a yet still unsolved problem in mathematics in the 24th century.

To the character the idea of solving it, even in a far future, was implausible. Yet when we watch it now it plays anachronistic because we are the 'more educated more informed viewer from 30 years later' who know Fermat's Last Theorem was solved by Andrew Wiles in 1994.

But it's still fun. Both then and now.

https://en.wikipedia.org/wiki/Fermat%27s_Last_Theorem

https://en.wikipedia.org/wiki/The_Royale
Do you really think government has power over companies anymore, and not the other way around? Future pharma profits must be protected at all costs.

This "nationalizing essential drugs" business could set a dangerous precedent after all.
There is nothing more frustrating than searching for information on old reddit threads and seeing that some useful comment that used to be there is gone because the user nuked all their comments via a script. I understand the privacy reasons but at the same time it does ruin a lot of content on sites and can force people to repost old questions to get the answers again.
It seems technically interesting, but I'm not sure how I can convince my manager that reducing binary size leads to more downloads or sales. @aripickar mentions the Uber app saga, but since then Apple seems to have removed size restrictions on apps downloadable on cellular connections.
Are those the things the left or the media got unhappy about trump for though? Or was it the children in cages? "Covid will be gone in a few days" ? And the like?

The one where he was very proud that he could identify an elephant annnnd that proved he was a very stable genius?

I don't know what the two scoops or the koi thing are, but i do know the republican media has been pretending Biden is senile for a while now.
Why should an account delete remove private messages from others? If you delete your account at your cellphone cartier, should it remove text messages you've sent from everybody's phones?
I was a customer for 13 years, a rather happy one for a decade of that... Oh the memories...
I've been trying to push property-based testing at work but there's not a load of enthusiasm showing. I guess it's in part because we work in C# and the best option appears to be FsCheck, which is very inconsistently documented between its F#-native and C#-accessible APIs.

I think there's a strong argument with FsCheck to write all your proptest code in F# just to take advantage of the vastly better generator syntax, but that's a hard sell for a team who mostly don't know F# and aren't convinced proptests are much better anyway. Writing the generators in C# seemed really incredibly tedious. I did start to get the hang of identifying properties to test though. Once you're past the mechanics of "how does this work" that can become much easier.

A load road to travel here, but I kind of gave myself a remit to improve software quality and I do think we need to be looking at this kind of testing to help.

Where do people who are using it find that it offers the most value? I keep feeling that we could really solidify some of our bespoke parsing and serialisation code using this kind of tech.
All the talks have been pre-recorded and already uploaded. So, yes, this year they will be available even faster.

The advantage of attending the scheduled time slot is that the speakers will be present to answer live QnA sessions with the audience in every talk.
What are the rules?
Love this analogy. I feel like it's intended to me. I've been part of this Indiehacker movement since last 2 years building Remote Leaf[1]. Sometimes I worry too much when I get 2 churns in a day and happy next day when I get 1 new customer. I hate these process.

Instead of trying to be like growth at all costs, I need to follow your strategy. Just help people. Just improve the product. Just do the gardening.

[1] - https://remoteleaf.com
Haha, this is so exciting. Thank you for sharing. I could feel the thrill from the bandwidth cut off.
The bigger problem with most of these memory systems is eliciting correct behavior of amnesia in case of both electric and chemical shock, as well as permanence or lack of permanence of those amnesic inputs.
The contents are the same; the formatting, presentation, accessibility, etc, are much better in the ebook (an ebook isn't just a printed website).
Thanks for the link. If you don’t mind, can you explain how this is different from what NCS (No Copyright Sounds) [0] is offering?

[0] https://ncs.io/
I recommend virtualenv and virtualenvwrapper. I usually set up a new venv like this:

$ mkvirtualenv -a $(pwd) new_venv

$ pip install -r requirements.txt

When you want to activate this env and cd to the directory where you created it, you can simply do:

$ workon new_venv

That's all you need to know. It just works.
Add to this Portrait in Jazz and Explorations.

I’ve been listening to those four albums very regularly for 6-7 years now. For a while I listened to at least one of the four each night.
I agree that of all developed countries, tipping is most prevalent in the USA, but as a fellow Canadian I wouldn't assume our Amazon delivery people are being paid anymore. They are independent contractors and not subject to minimum wage laws. If anything, their effective wage might be lower because vehicle operating expenses are higher in Canada.
Cloudflare even supports sites like thepiratebay if I recall correctly. It does make me respect them more and makes me happy to do business with them.
Chromium reduces Root DNS traffic
This is really cool, Matt. Even cooler to see you on HN. Enjoy one of my jams.
He's not working in drug manufacturing but in research. The details of these machines will be trade secrets.

The pun in my statement was that Mr. Derek Lowe is writing a popular series of blog postings on dangerous chemicals. It is called "Things I Won't Work With".

https://www.bing.com/search?q=derek+lowe+things+i+won't+work...
> I've never open sourced it though because I guess it's a bit of a grey area - the sites want you to go to the full URL so they can show you ads etc

Another reason, which I think is fair, is that with full articles in the RSS feed, the feed can quickly become a fairly large chunk of data.
While it is a useful tool for users there are exemptions for the company. For example, if your account details have been requested as evidence in a trial then the company should not delete your account under a GDPR request.
Same thing I have with Twitter. Won't let me login until I send them my gov id ala nudes (no chance in hell of me doing that) so I can't even delete the stupid account.
I always thought removing the sender identification was a good middle ground.

i.e. John Does said, "Hello world" -> [Removed] said, "Hello world"
Who out there loves them some cron?
I guess they don’t try to pretend otherwise.
Here's one of the demos, running right inside your browser: https://gabrielgambetta.com/computer-graphics-from-scratch/d... If you right-click-view-source, you can see the whole JavaScript implementation right there.

This might be the easiest way - make a trivial HTML page with a <canvas> tag and start setting pixel colors in it :)
I think that in general patents, copyrights, trade secrets etc. have a negative impact on innovation by hindering potential innovators from building on the works of others. The question is, is that negative impact offset by the positive impact of the incentives to innovate granted by exclusive rights to IP?
Lovely post, and a great idea. I personally very much like the idea of not scaling - and in fact have done this for 10 years with our (still tiny) digital agency. We could have chosen to take on staff many times but instead opt for a lifestyle business where I can hang out and look at the sea and be with my wife and kids.

In building products, my biggest issue to date feels like it is that I rarely bring anything to fruition - but actually this article helped me with that. It really highlighted how it's ok to incrementally push things along, get to a couple of launches just for your own satisfaction, and maybe make a little bit of cash - but you don't have to have any aspiration to "make it big". Thanks for posting :-)
Just want to say that the UI and UX is clean and effective. I really enjoyed that.
Just start reading the documentation. Peruse it all, but read the important things in detail, and skip the blogspam tutorials. Sometimes, there's a good book, like "Learn yourself some erlang..." that you can go through that's very worth it, but mostly the raw API docs are best.
I think by Theorem 4.2 in https://math.dartmouth.edu/~pw/math100w13/haddadan.pdf the number of such shuffles required to have a positive probability on all permutations is 6.
Good point, I updated my comment with an edit: Healthy SF isn’t mandated, providing health care is (and the very limited Healthy SF coverage is basically the cheapest option, so most restaurants do that).

On the “dictated by statute”, I actually mentioned that because so many people figured it was! Much like sales tax, it’s often on the bill as if it’s a thing that the city has specified and that it was a city program (rather than the city mandating that larger businesses provide coverage). Many restaurants are quite clear about it “we use this money to pay for healthcare for our workers”, but the biggest surprise for me was that the “market rate” ended up settling at about 4%. When some restaurants instead do an $X/patron or $Y/ticket add on, it catches people by surprise.

Either way, I find it amusing what people are “willing” to pay for things, especially if we can get closer to living wages for everyone. (I’m all for more “taxes” on bills that somehow people prefer over menu items going up in price).

tl;dr: good point, clarified my statements!
Common carriers are regulated entities like shipping companies and telecoms. You get to be one through a huge amount of bureaucracy, negotiation with regulators, etc. It protects you from a lot of liability but also creates a lot of constraints on what you can do, what you can charge, etc. Either way, you don't just wake up one morning and discover that your company has become one.

https://en.wikipedia.org/wiki/Common_carrier
Does he mean `potter`?
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Ya did it
You should go actually learn about critical race theory, from critical race theorists, rather than from someone's opinion of a straw man
This indeed sucks, but it would be pretty easy to fix. Just allow your nickname to be deleted for old posts automatically. I don't think individual posts' privacy is what people are usually worried about, but the possibility of getting "doxed" when given an easy way to view all of their previous messages.
> This is my garden, and I intend to putter.

I was about about to correct that use of "putter" as a typo, but it seems it's a USAism. Never seen that before. I'd always thought machines/engines putter, gardeners potter. I put it to the super-accurate Purported Google Results Test:

putter in my garden - 7 million

potter in my garden - 142 million

putter around - 9 million

potter around - 363 million

putter about - 49 million

potter about - 581 million

Although when I put on a USA accent, there's not very much difference between my "potter" and "putter", maybe that's something to do with "putter" apparently being the US spelling.
We have a similar saying in my country:
One backup is no backup, two backups are a half backup, and three backups are a full backup!
I was going to say, that the DNA in all the brain cells is identical and unchanging, so it cannot possibly record memories. But I decided to google first, and found this: https://onlinelibrary.wiley.com/doi/full/10.1002/dneu.22626

It appears that the brain cells in particular actually do develop significant changes to their DNA.
~50 EUR, random no-name USB microscopes are surprisingly good these days. I use them for inspecting PCBs and SMT solder jobs.

Model names seem to change daily, but they are all very similar. Standard USB video device-class, so no software necessary. I just use guvcview under Linux.

Pick one that has "full HD" in the name - it's usually not true 1080p, but in my experience the picture quality is still better than the other ones that will have a PAL-like sensor in it.

Also, get one with a stand where you can adjust the height of the scope above the object with a screw.
The alternative is to get leaders through inheritance, which isn't any better.

I refuse to believe that is the only alternative.
GDPR isn't a blanket deletion. Organizations can still retain personal information about customers for situations where they deem the data is still necessary for the original purpose.

e.g. purchase history, legal agreements, etc.
archive.org the net label scene.
That wasn't my comment...Also, it's refreshing that you can project my emotion on me (did I say embarrassed? did I say it was unpleasant? did I say I felt it was a Voltairean epigram?). Even though I stated you were incorrect on my personal emotional reaction, you continue to not realize that you're incorrect about my perception on the matter. Let alone your question ('why...') was a hostile question instead of actually engaging someone. I offered an olive branch by trying to rephrase it. Then you take all pretenses away and judge me without merit or grounded in fact.

I asked you what your question was but instead of realizing that you asked me a judgemental question (which isn't really a fair question...you presume guilt), you continue with your judgement without the facade of asking. You told me what you thought. Now, this latest comment, you're expounding as if you're doing someone a favor but instead it's condensation and gaslighting my perspective.

As for these longer follow-up questions. Honestly, if they got downvoted, I'd just laugh because it would only confirm how immature the readers are (which does happen occasionally but is rare) but instead, I wouldn't edit them b/c objectively, I'm not in the wrong on these longer posts. And someone would be hard pressed to say anything to the contrary.

To be clear, I'm standing my ground on my right to do what I did, for my own reasons and it was pointless/meritless to throw me into the mix of someone trying to provoke a flamewar. Which is a presumption beyond any evidence (even the deleted evidence) can verify. But...maybe I'm 'guilty' because someone might have power over me and they projected their negative mental patterns onto my comments? Cool world. Seems like the irony of my original comment! But I hope that rationality comes.

Instead, it was an innocent comment and the reaction has been anything but mature or consistent. I've seen even more superficial, pointless, and antagonistic comments than mine daily on HN, yet it's rare to see them squashed. I've checked multiple times. It's hit/miss, since HN has scaled over the years.

Take a step back and chill out. /fin
Is it that polarizing to /suggest/? I for very honest and reasonable reasons (one of his most prominent political positions prior to his presidency was aggressive use of nuclear power) worried he would and flinched anytime I saw unexpected aircraft for the last few months.
Google in Dark Mode
not only is it possible it is proven: https://www.nature.com/articles/ncomms15694

Also remember that two pharaohs had red hair
Jurisdictional win for Germany in lawsuit seeking to recover art taken by Nazis
"some" is the key word here. If he cashed "some" only to buy himself a house, I am pretty sure he doesn't need to pay taxes on that, except maybe the notarial taxes inherent to the transaction itself.
Their whole business is based on testing the limits of how much you can squeeze out of people using the very advantage of being a huge company.