skysight-inc/HackerNews huggingface dataset:
* https://www.thelancet.com/journals/lanrhe/article/PIIS2665-9...

"They included 30 569 patients with systemic lupus erythematosus or rheumatoid arthritis who were already taking hydroxychloroquine in the 6 months before what was considered as the start of the pandemic in England and 164 068 patients with these rheumatic diseases who did not use hydroxychloroquine. The study found no significant difference in standardised cumulative COVID-19 mortality associated with hydroxychloroquine use (0·23% among hydroxychloroquine users and 0·22% among non-users) with an adjusted hazard ratio of 1·03 (95% CI 0·80–1·33)."

* https://www.acc.org/latest-in-cardiology/clinical-trials/202...

"Among patients exposed to patients with SARS-CoV-2, hydroxychloroquine, administered within a median duration of 2 days as post-exposure prophylaxis, did not reduce the incidence of SARS-CoV-2 or COVID-19 infection within 14 days, compared with placebo (vitamin C)."

* https://www.nih.gov/news-events/nih-research-matters/hydroxy...

"Researchers assessed each patient’s condition 14 days after being assigned to a treatment group. They used a seven-category scale ranging from one (death) to seven (discharged from the hospital and able to perform normal activities). The results showed no significant difference between the hydroxychloroquine and placebo groups. The scientists also found no differences in any of 12 additional outcomes, which included mortality 28 days after assignment to a treatment group or time to recovery. Based on the data, they concluded that hydroxychloroquine was not an effective treatment."

* https://jamanetwork.com/journals/jama/fullarticle/2772921

"Several published rigorous studies have demonstrated similar findings. In the well-conducted clinical trials published to date, hydroxychloroquine has been evaluated in a wide variety of populations, ranging from patients with severe illness2-4 to individuals at risk of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, in whom the drug was used as primary prophylaxis5; these studies failed to show any beneficial effect of the drug. This raises the question: How did medicine get to the point where so many studies were conducted assessing the possible benefit of hydroxychloroquine, that led to nearly identical findings, and have been published in major journals?"

* https://www.nejm.org/doi/full/10.1056/NEJMoa2022926

"Among patients hospitalized with Covid-19, those who received hydroxychloroquine did not have a lower incidence of death at 28 days than those who received usual care."

* https://www.cdc.gov/mmwr/volumes/69/wr/mm6935a4.htm

"New prescriptions by specialists who did not typically prescribe these medications (defined as specialties accounting for ≤2% of new prescriptions before 2020) increased from 1,143 prescriptions in February 2020 to 75,569 in March 2020, an 80-fold increase from March 2019."

* https://www.aljazeera.com/economy/2021/1/27/oklahoma-attempt...

"Oklahoma tries to return $2m worth of hydroxychloroquine"

Under what circumstances does it work?
They did it to avoid going out of business due to DTCC collateral calls.

Stop spreading FUD.
10x isn’t just 10x. Everyone knows that low numbers can be skewed wildly.

Most people don’t mitigate risk as much as possible. Even hospitals don’t don’t do this. Hospitals routinely give unnecessary c-sections, drugs, etc to save THEIR time. A home birth eliminates these.

Did you earn as much money as possible and fly to the absolute best hospital in the world? Did you or the mother strictly watch weight? Obesity is a known risk that is poorly mitigated. Is the house free of all known toxins? Did you verify this with a particle sensor? Did the mother practice how do a birth without need for drugs?

With my wife’s home birth, we did these. My wife was is tip top shape, and my environmental engineer father brought over his array of very expensive sensors that measure down to parts per quadrillion.
WSB is trying to create a short squeeze by buying call options to crush the shorters.

RoaringKitty found the stock underpriced in 2019 and then managed to turn 50k into 13M in 1.5 years + and is still holding 22M in stock and calls.
tldr "Use your brain to think of words that are good"
"How to make a webpage fast and performant",

- Starts to explain how to use the most obscure javascript functions

- Explains how to show a real time , websocket animated globe of users of github

Lol
I can guarantee you that my vote in the 2020 presidential election had absolutely zero impact on who my state electors voted for, let alone impacting the race at a national level.

I would have to be a complete moron to think my vote had any impact on choosing the winner.
What is the excuse to have this contract censored? I understand what it's in the interest of security for example, but this...?

Also, where are the people who laughed about Brexit now?
don't worry, we can just do it again.
DHS made a tool months ago allowing you to play with temperature, humidity, and UV light: https://www.dhs.gov/science-and-technology/sars-airborne-cal...

UV light is the most significant factor of these three by far.

Considering this tool, I'm not sure what new contribution the referenced study is making.
> Between pyodide, pyo3, rust-cpython, and rustpython, I think Pyo3 is the best way to drop in rust in a python project for a speed up, if that is your goal. Some of the demos show using python from rust, but to me the biggest feature is without a doubt compiling rust code to native python modules. I'm using it to speed up image manipulation backed by numpy arrays.

> There’s a setuptools rust [0] extension package that can be used to hook the compilation of the rust into the wheel building or install from source. Maturin [1] seems to be regarded as the new and improved solution for this, but I found that it’s angled toward the using python from rust.

> There’s also the rust numpy [2] package by the same org which is fantastic in that it lets you pass a numpy matrix to a native method written in rust and convert it to the rust equivalent data structure, perform whatever transformation you want (in parallel using rayon [3]), and return the array. When building for release, I was seeing speed ups of 100x over numpy on the most matrix mathable function imaginable, and numpy is no joke.

What sort of algorithm was that? Generally getting 100x speedup on vectorized code is highly unusual even using handcoded c++. So I suspect it was quite loop heavy? In those cases I have also seen very significant speed ups.

I have been using pythran [1] for speeding up my python code. It generally achieves extremely good performance. I have blogged about it here [2] and recently a member used pythran to speed up some nbody benchmarks [3] which was used in an article to argue for using compiled languages.

That said I find pyO3 quite exciting and have been contemplating to try it with some of my projects.
[1] https://github.com/serge-sans-paille/pythran
[2] https://jochenschroeder.com/blog/articles/DSP_with_Python2/
[3] https://github.com/paugier/nbabel
Motivation determines if it's illegal. There's plenty of legal precedent for brokers setting assets to liquidation-only when they might not meet their margin requirements.
J&J and Novavax Data
> don't process stuff you can't see.

There are absolutely optimizations that can be made to process items that aren't visible on the screen. Everything is deterministic, cyclical and can be represented as a graph. Given the initial number of resource at a node in the graph, and a time duration, you can calculate exactly where each resource will be at any time.
I get the argument, but what’s the upside of the US approach? Germany is on par or better in society happiness (couldn’t find a metric to confirm that). Why do so many people feel the empty need for soulless growth of these monster companies?
"Small businesses" is starting to become "think of the children!" No one is entitled to my data, not FB and not "small businesses". So when my phone/mobile OS manufacturer says, "we're not going to let you have access to those data", quit yer bitchin'. But let's be honest about what is being said: it's not that such moves hurt small businesses, but rather it hurts Facebook's ability to sell to small businesses.
Let's give Google apps 1 star on the apple app store
What do they mean by "knowledge diversity is a double-edged sword that has opposing effects on [the two dimensions of team creativity,] novelty and usefulness"

So (more) knowledge diversity = (more) novelty and (less) usefulness? or is it more = less and less
Learning to Reason over Tables from Less Data
> Excess mortality shows us ~100,000 extra people died in the UK since COVID started.

It still doesn't negate the argument that it only affects the vulnerable.

And those in the hospital beds: what were their conditions while in there? What were their underlying health issues (if any)? Did they recover?

I'm not saying people don't get sick, I'm saying the cure is worse than the disease especially when the ones dying are a tiny fraction of the population.

Edit: I live in Scotland - we have had the "sick man of Europe" title for a long time and we have an obesity crisis here [0]

[0] - https://www.obesityactionscotland.org/media/1026/obesityfact...
Facebook is no different than any other business in this case. If you walk into a restaurant and you are rude to the waiters or you cause a commotion that restaurant can refuse your service and kick you out. Or heck, maybe they just want to close early. Legal and moral. If you are Black and walk into a restaurant and you are refused service that is both illegal (in the US) and immoral.
To each their own, but I find it an interesting dynamic. I’m having a hard time understanding the problem, but the game does have a learning curve. Suggestions: The majority of my belts carry one item. The remainder carry only one type in each lane. Those are neatly merged at the beginning, and consumed indiscriminately at the end. That is, the consumer wants both items so they can be transferred by one inserted. I never pack a belt to save on belts or space.

I’d hate for this to be the nit that stops a person from going deeper into this amazing game.
PNG is lossless while JPG is lossy so I'm not sure how you'd want to do this.
>> (2) Isn't this the regulator's job?

Is the regulator in this case the SEC, the exchange, or some other party?
It’s mind boggling to me that “best reasonable effort” made it in there multiple times. That’s so vague and up to interpretation, who can blame them that they sold the supplies for 3x as much to another country?

Anything can be construed as “best reasonable effort” - or is this specific legalese I’m unaware off?
I think that they are measuring the correct thing. It’s useful to know how temperature affects the molecular structure of the virus. From a quick glance at the study, they aren’t trying to determine how weather is going to affectHuman behavior, but I’m sure it will be misunderstood this way.
> What is wrong with that? It goes without saying that staying mid-sized doesn't mean staying complacent, but you can innovate without growing huge.

There is nothing morally wrong with this and I think most Americans are entirely in support of this ethos. In fact it is a truism that politicians are always talking about how important "small businesses" are.

But the emergent property of our corporate finance system is that those businesses get swallowed up or crushed by huge conglomerates over time. We have a pretty toothless anti-trust regulation system these days and big corporations have enough economies of scale, regulatory capture, and other practices to destroy any business below a certain size.

It's as if there is no protected shallow water in the business ecosystem. You're always in a place where a shark can get you, so if you aren't as big as a shark, you're bait.
Uh, link please?
A way to make GitHub's new homepage strictly faster is by removing the dynamic bits
Greed is really only a problem when your actions ultimately hurt someone else.

In general, shorting stocks is a beneficial action because it helps prevent shares from becoming overvalued.

So, yea, the fact that GME had 143% of its shares shorted is a function of greed. But, no, greed in this case was not a problem so long as GME's share price was fairly valued.
You might check out https://shapez.io, which is a simplified (an open source) clone with single-lane belts.
They are only legal if the reviewer attaches proof of all claims made in the review and the interest of the reviewer of publishing the negative review outweighs the interest of the reviewee of not having it published.

Which is the courts way of saying "it is illegal when we see it, we just leave some nominal loophole noone can fulfil so we don't go against the letter of the law". All of this is just a lot of court cases influenced by some elaborate schemes to pick the right court (LG Hamburg preferably). But unfortunately those stand as long there isn't an explicit law changing the situation. Which won't happen, because the exact same laws and especially judgements defend corrupt politicians against journalists.

Also, any kind of free-speech movement is a no-go in Germany because "buhuh, but then the NeoNazis can say what they like!".
Person who laughed and still laughs at Brexit here. The contract terms of the british contract has not been uncensored as far as I know?
You wouldn't have had to spend so many hours on making the page fast if you had just cut down on some of the fluff and focused on the content instead.
For difficult problems, find the mode may (a) be as hard to find, or harder, as doing an MCMC sampling run, (b) be completely unrepresentative of the overall distribution.
Cities don't have much ability to handle bad cops though. The police unions are too powerful
Pretty misleading title, actually.
IANAL but I think it qualifies as legalese you're unaware of.

Also, just by definition, whatever the lawyers agreed on is likely appropriate in a legal context and a layman's criticism of the language is almost invariably because they're missing the knowledge. Imagine said lawyer reading your code and challenging you on your API design.

Anyway, if challenged in court, AZ would have to demonstrate that they actually made genuine efforts before going down a different path.

The addition of the word "reasonable" is because they need an out in case they feel they've spent a decent amount of efforts. Whether that amount was actually decent or not is for the judge to decide.
Ooh, I didn't know about Cow Clicker. Thanks, that looks like a great example of this.
Yeah, that and "angels" mods are two very popular mod groups that make the game much harder and more complex.
>> Progress almost always comes from non-consensus outsiders.

Don't confuse cause and effect. This doesn't mean all anti-consensus ideas are genius and progress. Most are still just junk. See the "all big thinks initially looked like toys" meme for another example.
the enemy of my enemy is my friend, my friend.
Isn't it obvious that the "best effort" is not fulfilled if you you manage to produce 6 hamburgers to UK and one to EU when you specifically said in the contract that your facilities in the EU and UK are to be used?
[dupe] https://news.ycombinator.com/item?id=25951390
Commercially sensitive information? Doesn't seem too unusual to me.

And I'm not sure what this has to do with Brexit.
No such thing as too quickly if you've got a motivated planet.
P-Lisp, the Apple II Lisp (1981) [pdf]
All to Know About VPNs and Available Options
> In the meantime, /u/DeepFuckingValue was doxxed today

He wasn't "doxxed." Why do people use that word so willy-nilly these days? Reuters did some investigative journalism and found out his identity through public sources. He's not a confidential informant, he wasn't trying to keep his identity a secret, and he was voluntarily interviewed by WSJ anyway.

And even if he was doxxed, it's up to the courts to decide of free speech outweighs the right to privacy. This is one of those edge cases that will sometimes be answered in the negative, and sometimes in the positive.
More Than a Dozen Apps with 'Misleading or Flat-Out Inaccurate' Privacy Labels
Not sure if it was the EU or AZ that did the (failed) redaction. (Yes, despite the fact that it was published on an EU website)

Anyway it seems that orgs keep falling for the "PDF redaction" caveats
There are many issues with the use of underline for headings:

1) Constantly fixing them to match the length of the heading, or just suck it up and always use the short form:

My Heading
----

2) You're typing twice as much. I can easily start a line with # to make a heading, vs write the heading line, then carriage return, then add a bunch of dashes to make it a heading.

3) This is the fatal flaw - you only get 2 levels of headings when using underlines.
> As has been stated elsewhere, it is easier to recover from alienating customers than it is from running afoul of the SEC.

Oh did the SEC decide to grow a spine?
Study: "Effect of ambient temperature on respiratory tract cells exposed to SARS-CoV-2 viral mimicking nanospheres - an experimental study". Accessible at: https://doi.org/10.1116/6.0000743

The title of the article describing this research paper is very misleading.

Here's the primary conclusion of the paper:

"Moreover, the ambient temperature changes from 4 to 40 °C had no effect on S-RBD-ACE-2 ligand-receptor binding and minimal effect on the S-RBD protein structure (up to 40 °C), though protein denaturing occurred at 51 °C. Our results suggest that ambient temperatures from 4 to 40 °C have little effect on the SARS-CoV-2-ACE-2 interaction in agreement with the infection data currently reported."

Where I'm from, the temperature regularly drops to -25 °C in the winter, so this study does not generalize well. In fact, the final conclusion is so weak, it may as well be discarded: "...results suggest...temperatures...have little effect...on the...interaction".

However, this study does prove that saunas and steam rooms kill SARS-CoV-2, as "protein denaturing occurred at 51 °C", which is well below the average temperature reached in a sauna.
Parsing real-world data with Rust: introducing the alias_all attribute in Serde
It is "just" photo-etching, with the big wrinkle that 40nm is way below the wavelength of light, so all sorts of clever tricks with diffraction have to be done to make it work.
> AstraZeneca, which are between a rock and a hard place here, has agreed to supply the EU at cost

For the sake of completeness AstraZeneca have agreed to supply all markets at cost, not just EU.

This was part of their contractual obligation with Oxford University.

The vaccine was developed with Oxford Uni funding, AstraZeneca signed an agreement to mass manufacture under the condition that it would be sold worldwide without a profit margin.
This is a fair point to consider. Perhaps my claim was a bit overbroad.
>There's a much easier way? Remove access to weapons.

There are no simple solutions and to pretend that all you need to do is X and then therefore everything will work is naïve to the extreme. This kind of argumentation, where reality on the ground is ignored in favor of some pie-in-the-sky hypothetical policy, is not actually conducive to actually helping people suffering from crime (not just gun violence but crime).
I consider software architecture to be extremely important and based on the other opinions of the author he probably agrees with you that it should be "just-in-time", as do I. Useless abstractions just get in the way and make things complex and hard to understand.

Yes, if a program doesn't function the way it's supposed to, it's useless. Unfortunately I've seen many developers take shortcuts and not even think about the software architecture (because "hey, it works doesn't it"). Good software architecture not only makes it much easier to build functioning software, it also makes the team function much better. The ability to maintain the software and quickly add new features depends on it. Even little things you do can contribute to a good software architecture.

Overengineering leads to a terrible mess, so does the "hey it works, I don't care about anyone who has to maintain it" mentality. Ideally you'd be somewhere in the middle. You shouldn't design everything up front and you shouldn't ignore things that are right around the corner either.
Experts are almost always right, assuming their assumptions are infallible. The skeptic's criticism is often not directed at the expert's conclusions but their axioms.

Red lines with green ink --> use a thermochromic ink, change the temperature.

7 lines all perpendicular to each other --> sure, in 7+ dimensions.

Solve the climate crisis --> geo-engineering.
I use to feel the same way, but I've been slowly incorporating the circular avatars into my own solution. I don't know why GitHub changed things, but from my own personal experience, I've found circular avatars to be "less distracting".

I'm guessing by cropping more of the image, my attention doesn't focus on them as long. If I want the focus to last longer, I'll still use rectangular avatars since they contain more information. See example below to see how I mix-match things.

https://imgur.com/a/2nlXekJ
When you're a political leader and you're paid by taxpayers to manage their livelihoods and decide their future you should put up with harsh criticism as part of your job be it proven or not, within reason.

But as it currently stands, the 1% use the anti-libel laws in their favor to censor anything that undermines their power/credibility.

For example, if you're a senator and while I don't have proof that you are corrupt, you can't possible tell me with a straight face that you awarding a lucrative public contract to the company where your daughter is on the board of directors, is a pure coincidence or a meritocracy, even if the paper trail says it's all squeaky clean.
I built my own computer, I will probably continue to build my own computer in the future. I also am very sympathetic to anti Apple arguments framed in the context of their proprietary standards which just seem obnoxious.

BUT.

Neither of those imply to me that people should be building their own computers. My life revolves around computers, either at work, or in my primary leisure time. I am well incentivized to learn more about them. My mom's life does not, it revolves around her garden. My best friend's life does not, it revolves around his wife and son. Could these people learn to build a computer and get a better one for cheaper by building? Yes. Would they rather pay someone or some company a small premium to build it for them so they can live their life? Yes.

This also pertains to the car example leading the article, as well as the existence of professional accountants, stock brokers, paralegals, lawyers, librarians, dietitians, electricians, plumbers, arborists, etc. I could do anything I want for cheaper by putting my own effort into it, but life is way too short to do everything, especially things I have no interest in.