skysight-inc/HackerNews huggingface dataset:
10x Genomics | Pleasanton, CA & San Francisco, CA | Remote (US Only) or Onsite

We're a rapidly-growing biotech company that develops software, hardware, and chemistry to accelerate humanity's understanding of biology. We were called out by C&EN as a technology that played a critical part for understanding the coronavirus [0].

Our software enables scientists to better understand human health, such as pinpointing the differences between a cancer and normal cell. We utilize Go, React, Typescript, and Electron to create intuitive visualization and web applications. Our data pipelines are primarily written using Numpy/Scipy/Pandas stack, but we're making increasing use of Rust [1].

We've always been remote-friendly and are looking for awesome people at various levels for the following roles: Product Manager, Frontend Engineer, Backend Engineer, Security Engineer, Embedded Software Engineer, Product Designer, Head of Platform, Engineer in Test, and many more.

You can learn more and see our job listings here: https://www.10xgenomics.com/careers/software. Feel free to contact me directly at kevin.wu@10xgenomics.com with your resume.

We look forward to hearing from you and good luck on your search!

[0]: https://cen.acs.org/biological-chemistry/infectious-disease/...

[1]: https://www.nature.com/articles/d41586-020-03382-2
Coming on top of the RootKit Fiasco, ( https://en.wikipedia.org/wiki/Sony_BMG_copy_protection_rootk... ) Sony has really burned its bridges with tech-savy users.

So much so, that I and many others have Sony on a 'do not ever buy' list.
The people you're snooping on don't hear any buzzing quadcopter rotors overhead.
I don't have a problem getting my fingers down everywhere but the corners of the handle, so just pushing a paper towel down there works fine; I wouldn't be surprised if people with bigger hands than mine have more trouble, though. In practice, I've mostly just been throwing it in the dishwasher.
Join the First All-Civilian Mission to Space
Microsoft has also acquired every good mid-sized game company with a track record in the last 5 years to their Xbox Studios. They are really good at this while Google, obviously has no clue what they're doing.
You might consider contracting. I've been doing that the past few years and loving it. One of the things is that I get to (have to, in fact) choose my projects, so the clients I say yes to are ones whose projects I am interested in at a level beyond just "you'll pay me". They also tend to be in my specialties (UI, graphics, C++, iOS, in my case). I find that I learn a lot more, too, because generally the projects last about 6 months, and inevitably they use things I don't know about. In the past few years I've learned: TypeScript, WebGL, WASM/Emscripten, CMake, "github workflow", pybind, basic Ruby, basics of physically based materials (PBR) rendering, new UX patterns, how to convert Bezier curves to renderable line segments, basic image processing with OpenCV, Dear ImGUI, and vector graphics with OpenGL. I did not know any of these when I applied for the contract in question (in fact, a contract I thought was going to be a C++ or at least C# contract ended up being TypeScript, which was a tad scary for a day or two), but they start to accumulate and make me even more valuable. I think being a generalist as a contractor is an advantage, it gives more areas where you can demonstrate "I did this". I also think clients value age in a contractor more than employers do in an employee, because you can show a long list of similar things you have delivered and it's clear that you have experience successfully solving problems like yours.
Hear hear. Even on here people were throwing conspiracy theories around like they're facts...
While both BQ and Snowflake are adopting lake features, they still only support parquet and other file formats for loading, not for querying.

Can't do a simple

select * from s3://file.parquet

which you can do in Spark. Having to load it into the data warehouse means that you duplicate your data two times and it is stupidly annoying.

Many times the data doesn't even resemble anything tabular before I structure it in python scripts. Why would I load it inside a warehouse only to then pull it down to do some python processing and loading it back. Which makes the data travel from DWH storage to a data lake and then to my compute cluster and then the same cumbersome roadtrip back. Pretty wasteful. Spark at least allows me to schedule a python function across a cluster while copying only from lake to my compute node and back.

Data warehouses like BQ and Snowflake are great for data scientists after a bunch of engineers slice and dice raw data into clean tables. For anyone working with not yet structured data, data lake wins hands down.
Careful, this much sarcasm might break the website
In part I agree. If you have "a + b", and a and b are Employees, what does that even mean? Does it commute? Who knows?

But "adding" strings specifically, that idiom is I think sufficiently well established that it's in the category of "know the language - you're not in C anymore".

I want operator overloading. I want to be able to use + for adding, say, quaternions with integer components modulo n. (I also like my operators.) I want to be able to use | for or of fuzzy booleans defined as reals on the closed interval [0, 1].

I don't want + for Employees. But given what I do want, I don't see how anything other than good taste can allow the one and prohibit the other.
I'm assuming (as a US based company) that you're still required to feed all data to the National Reconnaissance Office (https://www.nro.gov). Has that policy changed as well?

Edit: apparently NRO doesn't host their website on the bare domain.
no you are not. i used to be very interested in gaming until the trend toward remote terminal consoles began.

I havent bought a game[among other digiassets] for some time.

If its not on physical media, if it requires an internet connection to even see runtime, im not interested anymore.
Level Benefits | New York, NY or US/CA Remote | Full-time

Level is improving healthcare by offering a new way to find, manage, and pay for care. We currently offer dental and vision insurance, and are expanding into other pre-tax and stipend benefits.

We have clear product-market fit, are growing fast but are still small and agile, and are looking to hire for multiple roles on our Engineering and Data Science teams.

Check out our roles and apply at https://level.com/jobs, and email me if you’d like to ask questions directly: shayne@level.com
How is this different from a crime that happens in the middle of nowhere somewhere else? There are lots of places with no inhabitants and no courts.
Sorry I read the page and I found it very vague.

Pretty graphics and lot of white space for not much meat.

Basically, looks like the command pattern implemented with signed token for every time you read, you must mutate the 'chain' or array of information. Am I close?
Finger.Farm
https://finger.farm

Love a good / dubious project I can bang out over a rainy weekend. Finger.Farm is a modern re-implementation of fingerd in Node, but with an API and whatnot. I built it mostly as a demo for the Jr devs on my team who haven't had the opportunity to finger each other, but there are some ideas there I might bring back in other projects...
> Regulatory requirements usually does box you into a waterfall sdlc.

This really isn't true, at least not for this context.
>There are several ways to rebuild a table and reduce bloat:

>Re-create the table: Using this method as described above often requires a lot of development, especially if the table is actively being used as it's being rebuilt.

>Vacuum the table: PostgreSQL provides a way to reclaim space occupied by dead tuples in a table using the VACUUM FULL command. Vacuum full requires a lock on the table, and is not an ideal solution for tables that need to be available while being vacuumed:

This is confusing to me, i thought postgre was suppose to be better then mysql, yet mysql has a non-locking command to recreate a table. it has like 3 that would fit here, AND deal with the indexes in one command.
Meh, another HN complainer going on about<click>...OMG, what the hell is up with that web page?! That some truly nausea-inducing scroll behavior. Is there a RNG behind it somewhere?
The first commercial astronaut mission to orbit Earth aboard Dragon
VLC is one of my favorite projects of all time. Hard to believe I’ve been using it this long. Happy birthday to the project and congrats to all the contributors!
Agreed on the regional rules and the spaghetti and meatballs might indeed be related to the dish you mention. However, while you _can_ have spaghetti and meatballs in the "Italian food grammar", people from Abruzzo might be even more horrified by the American dish: 1) their meatballs are small enough to be part of the sauce. You don't have to tear them apart 2) the pasta remains the base of the dish rather than a kind of side 3) you would never serve "plain" pasta with the sauce and meatballs on top [1], the sauce and to some extent the meatballs would be well mixed with the pasta before it reaches the table.

So it's not the concept of spaghetti and meatballs, but rather the way ingredients are balanced and presented.

[1] https://www.bettycrocker.com/recipes/spaghetti-and-meatballs...
Ask me in 11 years.
It really is wonderful to see how food is adapted between regions and cultures.

It drives me crazy when I see people concerned about "appropriation" when one culture adopts the cuisine of another (appropriation exists, but the usages I've seen apply it far too broadly). People want others to enjoy what they enjoy. It's great to share recipes! I know that ordering American food in another country will not get me what I expect... and that's totally fine. The adaptation might not appeal to my tastes, but that doesn't make it bad. It doesn't mean they're not allowed to call it American food.
Pleasantly surprised that it's an analog innovation rather than IoT Velcro Straps. I'm sure the latter isn't far away though.
Kettle | Remote, Full-time | https://wearekettle.com/

Kettle is a growing, award-winning digital agency. We are a team of thinkers, makers, and storytellers who love working together to build ambitious, human-centric experiences. We create digital-first products, content, and campaigns through carefully crafted partnerships with the leading brands of today and tomorrow.

- Front-end developer (native DOM, JavaScript): https://wearekettle.com/jobs/apply/front-end-developer-71588...

- Full-stack web developer (PHP or Python): https://wearekettle.com/jobs/apply/full-stack-web-developer-...

Have questions? Reach out to me directly: jacob {@} wearekettle.com
Wow, this is cool! I understand if you don't want to give away the secret sauce, but how did you get vim working so smoothly in a browser?
Simplistically, yes. At IPO when potatoes are very first introduced to market, he decides what he thinks they are worth. The market will quickly decide the 'real' price.

Whether his first asking price is £2.00 £12.00 the market will quickly decide the level. If potato's are the hype root vegetable, many buyers will appear, but if carrots are in fashion, the price of potato's must fall until in order to attract buyers
craftworks - Industrial AI | Austria / Vienna | ONSITE (regular remote) | Data Engineer / DevOps / SRE

We are a software and AI company with focus on industrial use cases. We develop own products and individual software solutions for companies in areas such as Machine Learning, Big Data and Software Development.

We're looking for:

- Data Engineers
- DevOps
- Site Reliability Engineers
- Software Engineers

Our stack includes Python, Java, Spark, TimescaleDB, Kafka, ...

More information can be found on our homepage https://craftworks.at/working-at-craftworks/
Just GPG Things
Finix | SF Bay Area | Full Time |Onsite(post covid) |Open to Visa | https://jobs.lever.co/finix/

Finix builds payments tools for vertical SaaS and fintech companies. With Finix, businesses can create a custom payments experience for their customers without developing an in-house system or relying on third-party payments providers. At the beginning of 2020 Finix was a 15 person company, now we’re at 100 people with $96 million in funding.

Tech Stack: Java, SpringBoot, React, Redux

Finix is hiring for:

- Software Engineer Intern - https://jobs.lever.co/finix/47edd4f0-8b4c-4da5-a5f0-a47c39ba...

- Sr. Software Engineers - https://jobs.lever.co/finix/a29ffb10-aead-4655-963f-ec47b27b...

- Sr. Software Engineers in Test - https://jobs.lever.co/finix/cf0c1008-8e8c-419a-8148-de293af3...

- Staff Software Engineers in Test - https://jobs.lever.co/finix/6a8106a7-784e-4f92-ba5f-6b829d91...

- Director of Engineering - https://jobs.lever.co/finix/47edd4f0-8b4c-4da5-a5f0-a47c39ba...

Find out why the next generation of payment companies won’t look like Stripe or Square:

https://tearsheet.co/podcasts/finix-payments-richie-serna-th...
>is it normal to get an EKG in relation to ADHD medication?

Not sure. My provider asked me to get one done. I talked to the cardiologist about this and she didn't seem surprised it was requested nor that I was the first to get it done.
On Stadia you don’t need to pay any subscription to play your games in HD.
Propine | www.propine.com | Remote, but must be willing to work within GMT+6 to GMT+10 | Full Time

Propine is re-inventing capital markets using blockchain technology. We’ve worked with Monetary Authority of Singapore (MAS), to become the first licensed custodian for digital assets in the world.

We are re-imagining the issuance and life cycle management of capital market products like equities, debt, structured products and funds using blockchain technology, to reduce friction and increasing value accrual for both issuers and investors.

We're hiring for multiple roles

- Legal & Compliance Manager
- Security & Solution Architect
- Senior Blockchain Engineers(Blockchain exp not a requisite)

Please contact Zan at zan@propine.com for more information
> This is absolutely not the case. Google’s biggest ad clients achieve pretty incredible ROI (called ROAS) on each dollar they spend.

Yet overall advertising spend is relatively flat. It's just shifted from one media to another.

Advertising will not collapse. Companies budgets for advertising is fairly flat as a percentage of revenue. Who get advertising dollars will shift, but even there, not too much.

Nor will we see more advertising. Sites have already bloated sites beyond the capacity of what most people will accept.

What will likely happen is more special interest content will continue to slip behind paywalls... much as it was in magazines and specialist journals you paid for prior to the web.
> With a bit of clinical context, do you think developers can write code with risk management in mind?

Absolutely.

Some people with more of a hardware bent are probably used to FMEA - but that requires a design to evaluate. Risk management approach (should) starts at the other end, while you are still understanding what your product should do.

If you do 14971 right (and iteratively), it will help you pin down key requirements up front that will help you avoid missteps that are costly to recover later.

One of the big shifts is that it makes you think about uncommon/incorrect usages earlier, as well as thinking about how other systems could mess with you.
Prenosis | Software Engineer, Applied Machine Learning | Full Time | Onsite (remote during COVID) | Chicago, IL | 90-130k | www.prenosis.com
Prenosis is an early stage molecular diagnostics company specializing in infectious disease and critical care. The basic premise is utilizing the combination of electronic medical record (EMR) data with novel biomarker measurements to make predictions of clinically relevant outcomes. These predictions are then used to ultimately guide treatment decisions.

We're currently hiring a backend or full-stack software engineer, ideally with machine learning/data science familiarity or experience. At a high level, you will work to facilitate the growth of our proprietary NOSIS dataset and to build and deploy machine learning algorithms into real world products integrated into hospital systems. You will be working with a diverse group of people including assay scientists, statisticians, clinicians, and quality/regulatory specialists.

Technologies we use: Python, R, Django, Flask, React, PostgreSQL, Docker, AWS, SMART on FHIR

If interested, send an email to jonah.ellman@prenosis.com
> but I've never thought that meant there was anything "wrong" with me

That's a good dividing line between 'actual pathology' as you say and normal experiences.

I always felt like something was wrong with me. From childhood, I was different. Never could put my finger on it, but a lifetime of experiences gave me some intuition that I was different, in a bad way, and that was just my lot in life. Fast forward to my early thirties, and after being fired from every job I'd ever had I reached rock bottom. I was a 'gifted' student, elite engineering degree and a law degree, but just consistently failed to live up to my potential. I finally dragged myself in to a therapist's office because I had intense and intrusive suicidal thoughts nearly all day every day for months. I didn't want to kill myself, I had a lot to live for, but some part of my subconscious was absolutely fed up and done. I never once thought that I was someone who could have ADHD. I was bright, I had a decent academic record, and I had gotten several high paying jobs. ADHD was about jittery kids or losers working menial jobs, not me. By the end of my first session, as my therapist would later reveal, he knew I had ADHD. It took some time for me to accept it. But once I did, and got on board with treatment including medication and regular therapy, my life changed. It made so much sense in retrospect. I did have a good academic record, but that's only because I could hyperfocus and ace exams - I never did homework on a regular basis from grade school through grad school. I wanted to, but never did. I did get high paying jobs, but would wind up being fired a year or two later because getting a job is exciting, keeping a job and, you know, doing a job, is boring. At least to a part of my ADHD brain it is. Everyone experienced boredom, but how many people let that boredom get them to a point of being unemployed when they have a wife and children to support? It's not a choice.

Frankly, I'm lucky that I happened to meet the right therapist at the right time that recognized the ADHD that was causing so much turmoil in my life, and I am forever grateful because I truly believe that without realizing it was ADHD and treating it, my children would have lost a father. ADHD is real, and it's serious. I ask you and everyone reading this who doubts ADHD is real to please try to find some empathy.
if you can allow users to load the code out of the cloud and or the user swarm ; onto thier machine and then dissconnect from the cloud, the potential efficiency is even more staggering.
I'm going to own my truck for 25-30 years. Android devices are abandoned after 2.5-3 years.
>I was looking forward to seeing some of the games that would have only been possible on Stadia's architecture. Imagine a Battlefield-style game with a larger map and over 500+ simultaneous players.

Never. As a game developer you don't want to be tied to a specific system.
Just realised another user reported that it did not work well for Russian movie and Polish subtitles. Nonetheless, it doesn't stop you from training your own subaligner with those media assets you possess.
Here are some quotes from Mongo's start page

> No database makes you more productive

> The most popular database for modern apps

What we have here is not really something intended for a specialist usecase, as implied by your comment. Mongo is clearly pushed as being the best database, used by most "modern" apps.
I had no idea that was still practiced. Thank you for sharing.

What is the ISP injecting into page?
It's not FUD. It happens. It might be a small percentage but it's real.

There's a case of someone close to me that works in the ER that was positive around November with very little symptoms, got cured and now has it again but with stronger symptoms.

And from the antibodies tests done to the health personal in that hospital, it seems some people get good antibody response and others not so much.
>I was looking forward to seeing some of the games that would have only been possible on Stadia's architecture. Imagine a Battlefield-style game with a larger map and over 500+ simultaneous players.

Never. As a game developer you don't want to be tied to a specific system. Never be able to sell it somewhere else.
> I'm not great at signing anyways, ha

You mean well, but it looks like David Lee isn't fluent either. Have y'all included Deaf folks in this? I'm not deaf but I learned from folks who are... and well-meaning hearing folks was a consistent theme in learning about Deaf culture.

The dataset is questionable, and I note that his classifier has problems recognizing the g and h handshapes because...

(quoth wikipedia) > In most drawings or illustrations of the American Manual Alphabet, some of the letters are depicted from the side to better illustrate the desired hand shape. For example, the letters G and H are frequently shown from the side to illustrate the position of the fingers. However, they are signed with the hand in an ergonomically neutral position, palm facing to the side and fingers pointing forward.

David's example shows him holding his wrist in a position that would quickly cause RSI (but his son gets it right). Consider: it takes me under a second to spell "gerontology", and I lost fluency years ago.

This chart depicts those handshapes more accurately:

http://www.queerasl.com/wp-content/uploads/2018/01/ASL-alpha...
I agree that’s wrong. Sounds like potential fodder for some of the ongoing legal surrounding Facebook.
Architecturally, are Google's Stadia servers substantially different from a standard PC?
could you perhaps try with a real comparison at : https://photos.app.goo.gl/gwokp4WT8JPvyue98

or explain why its the same image psd'ed to low rez?
I've often wondered- are there solid studies on responses to stimulant medications varying over different groups?

It's definitely true that there is wide individual variance (modafinil does nothing but disrupt my sleep and make me more sleepy over time, alas), but it is less clear to me that the differences follow cleanly along boundaries like ADHD/not ADHD.

I don't have ADHD, but I am prescribed Ritalin to help with a sleep disorder. There's no high, euphoria, or hyperactivity, just a boost to wakefulness and general mental function. Descriptions of the effect from people with ADHD sound familiar, just starting from a different baseline.
I saw far more people saying 'I don't think stadia will be around in 5 years' than I saw people buying into it. I don't think people are very suprised by this, google has basically destroyed people's faith in the staying power of their products outside of a small core.
I'm Irish by descent and people who are, genetically, adapted to the environment you're describing and show up to, say, parts of the US northeast can have a hell of a time, especially in the winter. There's really no comparison between the UK and environs where it bascially doesn't get cold (really cold air more or less doesn't carry moisture) and where the climate is just really damp and the climate here. Add in radiator heating that is pretty intensive and you'll start seeing hte plaster crack off the walls due to the dryness, let alone what happens to your body.
Location: Spokane WA
Remote: YES
Willing to relocate: NO
Technologies: see www.themanitogroup.com &
www.andrewclapp.com

Résumé/CV: https://www.andrewclapp.com/experience/workexperience

I am a Product Manager with a history of developing and launching new and innovative products. Capable of autonomously managing each aspect of the business from ideation to scale. Can consult on projects through the Manito Group or work as FTE.

Email: andrew@andrewclapp.com