skysight-inc/HackerNews huggingface dataset:
Cruise missile delivered mine is something to think about... Plenty of close in guns and missiles to prevent direct attack, yet you could very rapidly area-denial an area with cruise missile delivered mines.

If a naval patrol covers more than two hours per leg, they can deny incoming missiles from directly hitting a carrier or whatever but they can't deny missiles incoming 100 miles away at the same time. Either way it prevents the carrier from operating in the area.
Sure, I wasn't recommending it. I'm just pointing out that it's culturally acceptable to give cats catnip. Culture happens, and sometimes it's rational. Sometimes it's not.
Pluto is the only place I randomly bumped into someone in the last 12 months!
Even as someone who's glad Biden is now president - it's a bit unnerving to be living in a time where a service bans the sitting united states president without batting an eye but engages in legal battles to defend the distribution of child pornography on their "open platform".

I guess people posting spicy takes on government happens to be more of an active risk to society than literal child predators?
Are these downloadable? Just clicking through didn't seem to have any download links available.

For context, I've been trying to learn color theory and put it into practice in photography. One of the things you could do to train yourself is to look at how the great artists of the past used color - of course if you have a great eye, maybe this comes naturally to you, but for me, I'd have to upload it to some site like color.adobe.com and have it extract the color scheme manually.

Ever since I started, I've been having so much trouble downloading photographs of the art work that I just started taking screenshots and using those instead. Kind of sad that what is our collective cultural history cannot be widely used because the photographer who took a photo of the art work didn't chose to make their high-res photo widely available.
Yes but it's fun.
If it was me, I’d have probably gone straight to Twitter too. My thought would be that they’re hosting the content, so they’d probably be able to get it removed the fastest. It also wouldn’t occur to me that an agent wouldn’t find CP to violate their terms. I’m surprised that Twitter didn’t take it down as a CYA precaution while they verified it to be CP or not.
I've used CadQuery a lot and found it to be a terrific tool. Sadly, its still very buggy and has not been updated in almost a year...
Death rate will surely go up if there are multiple strains of this going around that are different enough you could catch 'em all, over time.
Top Apache Kafka talks this year's Re:Invent
What's the cutoff on number of inputs/outputs/parameters for an empirical model to be considered "AI"?
Yes precisely. The MBA skill was to get credit for an obvious strategic possibility that required a huge team to pull off.

Happens on many levels though, it's not as if engineers don't get credit for team efforts.
It is important to note that the current mortality rate is the mortality rate with treatment, and with varying degrees of spread mitigation measures. If hospitalization rates exceed the available beds, the mortality rate will rise.
Please note, that neutralization by antibodies is only one of the many possible ways how our immune system can take action. Antibody recognition is still possible with the found mutant:

"To determine whether 501Y.V2 is still recognized by non-neutralizing antibodies, the binding of polyclonal sera (from Fig.2a) to a recombinant 501Y.V2 RBD+SBD1 protein and an RBD+SBD1 from the original lineage was assessed by ELISA (Fig.2b). These data revealed that binding of polyclonal plasma to 501Y.V2 RBD+SBD1 was only substantially affected in a minority of cases (14 of 44 with ≥five-fold reduction, 32%). Most of the convalescent plasma/serum suffered less than four-fold reductions in total binding activity (as measured by area under the curve), suggesting a considerable non-neutralizing antibody component are still able to bind the 501Y.V2 spike antigen"
The second best thing after print magazines' CD-ROMs... also extinct :-<
Article here: https://imgur.com/a/acJN0Ju

Is this guy writing an angry Yelp review that got cross-posted on BI?

Every place is what you make of it, and judging from the sound of it -- this guy has made little of it.

Instead he blames everything and everyone else because it does not match his value system, his climate tolerance, and his allergies.

On your horse, man. The road that brought you here can take in you in a happier direction.
Adding an url to a denylist is a lot faster than finding and setting up a new electronics assembly factory (or whatever these guys did).
It's a story that's so completely outside of my personal experience that I cannot evaluate it

In 14 years of holding a Twitter account, I've never seen anything even close to such things on Twitter, and wouldn't use the platform if I did. If I were to see child pornography on Twitter, I would immediately report it to law enforcement and close my account

Well, I hope that poor child wins justice.
It's interesting, but because they used to be at Intel that was on the path to today's misery, isn't that a bit worrying that they may be thinking inside the box and looking to again rehash tired and old architectures? Why not looking for someone fresh?
You are joking right? It in the rulebook of most sales folks... everywhere. Companies have special budgets for this.

I don't mean some trading-only companies like Cargill who have extra prostitues budgets (at least 5 years ago that was true, and with expensive alcohol parties was the only way to do any business in places like Russia or most 3rd world countries). I mean any kind of bigger corporation. Banks have it. Any kind of finance business does. You won't get far without it.

There are obviously rules, but often they go the other way - employees shouldn't accept bribes in forms of these gifts. But getting clients, that's a free for all, the winner takes all (and biggest bonus).
This conversation is distinct from blockchain as a technology, no?
For your entire life? IDK about you but I'm ok with getting a common cold or the flu once every few years to live a normal life.
> That should be relatively easy to do for the mRNA vaccines

That isn't super obvious to me anymore, after it was pointed out to me that the current mRNA vaccines rely on a modified sequence for the spike protein, designed to make the protein stable enough to be usable in the vaccine process (described here [1] as "antigen S-2P" - "S" for "Spike" and "2P" for the two proline substitutions in the sequence). It's my understanding that this work dates to 2017 [2], and that it might not be quick or easy to replicate for new spike protein variants.

[1] https://www.nature.com/articles/s41577-020-00480-0

[2] Pallesen, J. et al. Immunogenicity and structures of a rationally designed prefusion MERS-CoV spike antigen. Proc. Natl Acad. Sci. USA 114, E7348–E7357 (2017).
Let me rephrase the question. There's a vaccine shortage, how is there even an OPTION to have to pay people? The waitlist in many states is over three months for people over 65 or with specific conditions.
Presumably, they used the macOS/iOS kernel source code as a reference? I'm no expert on kernels, but a quick grep reveals plenty of references to "AIC" and "FIQ", in osfmk/arm64 for example.

https://github.com/apple/darwin-xnu
I think you have it backwards - If it is resistant to past immunity it will certainly knock out live virus vaccines, the statement is saying it will probably affect mRNA as well.
Ugh. Statistics, people.
That's right, sample size can vary a lot depending on several factors such as:

* Experiment design

* Sampling techniques

* Methodology being used on the model

But normally with a small sample size a bigger emphasis should be put on performing the appropriate statistical tests on the sample and validating it carefully, before applying any model. There are a lot of assumptions that should be validated if you are working with small data.

Unfortunately, I don't have access to the complete paper to verify the methodology used, so take it all with a grain of salt.
I am in charge of IT security for my company and in my experience users like you get put in a tough place. On one hand, you want the freedom to work however you like, but on the other hand the company has real requirements and limitations imposed on them that necessitate dictating how end users compute. I am also guessing that for every user like yourself who would gladly use a company provided device to keep their personal and work computing separate, there is a corresponding user who absolutely will not tolerate being forced to use an additional corporate machine and will complain until blue in the face about it. It's a lose-lose situation for IT.

There is also the matter of endpoint protection to consider. If I am allowing a personal device to connect to my environment, how do I know that device is secure? The only way to have any level of assurance to that fact is to install remote monitoring agents, inspect the configuration of the system, and restrict administrative permissions so the end-user (or an attacker who hijacks the end user's access) cannot mess with things in such a way as to compromise the already shaky ground the integrity of that system stands upon.

If I worked at your company, I would give two options: either use a corporate machine for work activities, or if using a personal machine for whatever reason then IT gets administrative control of the device. There is no third option. And before IT assumes administrative rights to manage the device, the end user is signing an acceptable use policy that they agree to any and all IT security controls placed upon the device. If that is unacceptable then the alternative is always to use the corporate device.

I am not sure if you're an FTE or a contractor or what your locale is, but IMO imposing that kind of control over a privately owned device without an agreement would be at best inappropriate, and potentially illegal. My response would have been "No, thank you." I do however sympathize that it is not always possible to take that stance.
However, the license means that someone can reupload the images to another platform, like the Internet Archive.

I checked, and while there doesn't seem to be a collection for the Rijksmuseum, a certain "NL_Archivist" has been busy uploading images from Het Utrechts Archief the past few days: https://archive.org/details/@nl_archivist

I wouldn't be surprised if they continued with the Rijksmuseum collection afterwards.
On the Pico itself? Unsure. But Arduino is already set to release a Nano version with the RP2040 and 16 MB of flash [1], so it's probably not crazy hard :)

[1] https://blog.arduino.cc/2021/01/20/welcome-raspberry-pi-to-t...
It would be interesting to empirically identify the state space that leads to increased probability of failure and then seek to understand the rationale for this failure through physics. Ultimately, the ML model is picking up on some combination of factors that exposes physical weaknesses of the device.
Depending on the underlying infrastructure.

Unless you freeze the infrastructure too, this is incorrect.
I'm really not. You're just doing that very-very-HN thing where you assume your surface understanding is sufficient.

Manual tasks in MSP are a very bad idea. There is no valid use case for them in critical path scheduling. They exist because some muzzy-headed marketer at Microsoft decided to insert them into the backlog, near as I can tell, despite the cries of actual professionals who use the tool.

There are ample ways to model constrained tasks in a critical path that do not involve a feature that is, as I said, tantamount to turning off "math" because you don't like what it shows you.
Started dancing back in the 90s in LA after the Swingers hype. Became of of the regulars at the Derby and other LA spots ( Satin Ballroom, Moras modern rhythmists on mondays). I met my wife there then and we are still together after all these years. I miss those hey days! Got to see Frankie several times, and the nickolas brothers, and all the old timers from the OG LA scene from the Balboa ballroom in the 30s and 40s, Hal Takier, Bart). Such an amazing time. Got to dance for the last time right before the lockdowns. Glad I live with my dance partner. I feel for you all who don’t! Doing swing outs with the doorknob on an open door was one way I practiced back in the day. That’s still COVID friendly!
In the case I described, the resistance came from people who invested years and $100,000+ into an MBA degree with an expectation that companies would reciprocate by moving them to the top of the compensation scale.

When they joined a company and realized that their graduate degree was not a guarantee that they'd be at the top of the payscale, they interpreted that as an error in the compensation structure.

The challenge is that many (though not all) MBA programs virtually promote this idea that an MBA is a key to unlocking the highest salaries. MBA program advertising material often implies that an MBA will have huge ROI and greatly increase their compensation. It can be a shock to land at dual-track companies and realize that compensation is a strict ordering according to credentials.
Nobody claimed that would happen. On the other hand, you claimed half the planet was going to die from Covid.
These are necessarily temporary measures. Life cannot go on forever with these restrictions in place. Either medical science will find a way to limit the danger or people will adapt to their new, more dangerous world. I am not an anti-masker, but asking for permanent social distancing is not realistic.
> When you get to the social sciences, evidence is much more easily wished for than provided.

Yeah, though that just means it's harder to actually find out what's true. That's why the replication crisis in psychological sciences is a crisis. We can't treat gaps in our knowledge like supporting evidence.

> Namely that activities on the part of police aimed at increasing trust within problem communities, result in those communities experiencing a decrease in violence and crime.

That sounds great, and does seem like you're right about that specific item.
Beyond raw benchmarking, here's an interesting use case from StadiaMaps. https://www.scylladb.com/2020/07/30/stadia-maps-using-scylla...
Albatross DemoNet
Linux can run on M1 Mac
I think maybe the programmer has forgotten to replace the mock data with a real data feed and he tells everyone who asks the same incorrect latitude and longitude no matter where they are.
Securing Secret Stores
Intel has to be better than ‘lifestyle company’ Apple at making CPUs, says CEO
What a great read. I think the authors here made great hardware and software decisions. OpenZFS is the way to go, and is so much easier to manage than the legacy RAID controllers imho.

Ah, I miss actual hardware.
Sure, reducing transmission rate makes you less likely to be exposed in the first place. But it's not an alternative solution to a cure.

Corona's have been with mankind since before history. They never go away and its a matter of time before you are exposed to one of the coronas again.
While those are certainly measures to take, they're a non answer. We need to return to some amount of noalcy, and none of those measures are up to snuff. Literally everyone where I live wears a mask and distances, yet cases are sky high. Somehow my grandfather caught the virus despite his assisted living home despite them being so locked down that we haven't been able to see him in person besides through a glass window. Masks and distancing just spread the deaths out over time, but they aren't a solution.

Believe it or not, some of us don't like social distancing and mandatory masks in perpetuity. If we had spent more money on developing these kinds of vaccines years ago, we might not be in the situation we are in now. If you like being isolated then be my guest, but don't be on a high horse about "just" wearing masks, and so forth at this point. We all get it. Yet people continue to get sick and die.
A CTO explains why you need e-learning at your company
macOS has a Hybrid kernel with a decent portion being micro components I thought?
Hey!
My name is Elie and I am the CEO of carbon payment ... I used to lead one of the payment team at Uber and I am working something similar... let's chat
It seems like it's only available on the Yubikey 5 Series

https://support.yubico.com/hc/en-us/articles/360016649319-Yu...
Will this work when cross-compiling from Linux? That's supported by Rust.
> It's a lot easier to get sunlight when you're not cooped up in a cubicle all day.

Or, forced to work from home and discouraged from going outside.
Improve the News – chose your news diet deliberately
re: E484K

1) it's in the spike protein. I think it's in the area that typically elicits antigen response. That's super bad news. If you look carefully, it's near the cleft of a representative antibody (fig 1a), and the buried surface area is high across the board on (clinically?) sampled antibodies (fig 1e), suggesting its importance.

2) it's a mutation that changes the charge state of one of the amino acid residues. E->K, changes a negative charge to a positive charge, potentially very bad if typically antibodies have a positive surface charge to interact with it, now they will be repelled. Since individual humans make random antibodies, even if there is no charge interaction, K amino acid is bigger than E, and so there is likely a shape interaction that could get disrupted by the "new bump" in the spike.

Is it a serious cause for concern? Yeah, almost certainly. The current round of vaccinations will probably be rendered inactive.

IMO the fastest way around this is to quickly approve a reformulation of the moderna/pfizer vaccines that encode for the new amino acid, or better yet, a cocktail of both.

For the more traditional protein-based vaccines, it could be more challenging, because the gut feeling is that an amino acid change like this could pose more of a risk to the effectiveness of the formulation for delivery of the vaccine (mrna is more "neutral" information medium that typically exerts less of a chemical change to the delivered product when altered).

In any case this emergent phenomenon will be certainly challenging to the regulatory landscape around vaccination.

disclaimer: I own MRNA stock.
PT may be expensive, but a good therapist is worth it. I abused my body by basically not moving throughout my 20s, and even once I got in shape I was prone to various injuries. The PT got me through a lower back injury, a hip injury, a shoulder injury, and a leg injury. These were not caused (except for the back) by traumas (in the case of the back, trauma exacerbated an existing issue), but mostly by some combination of weak muscles, poor form, poor flexibility, or overuse (overuse for me, a person in even marginally better shape wouldn't have had issues at my activity level). I kept up a lot of the things I did/learned there and, other than the back which will be a perennial issue, have not had any recurrence.

There's a lot of benefit to finding someone that teaches you both what to do and how to do it, and is also better informed and more competent than most fitness trainers. The good ones will also walk you through a basic physiology course so you can understand the why of it all (why did I become injured, why does this prevent or reduce the risk of a future injury).
> You know who manages by metrics? Big companies like Google, Amazon and LinkedIn.

This isn’t true through. On this very site’s Startup School you will find lots of experienced entrepreneurs advocating for a metric-driven approach to growing your startup. Maybe not “one metric that matters” all the time, but Lean Startup is about measuring your company’s metrics and running experiments week-by-week to see what moves the needle.

Sure, slavish and myopic adherence to a bad metric will lead you astray. But management without metrics will lead you astray too.
You mean turn the refrigerator into a growth box? While still being able to use the cooling function? That sounds like an interesting idea.

Not sure how live lettuce reacts to low temperature, it might go into faster growth and would actually start rotting sooner.

Many plants do that in sudden weather changes.
I think it's more like limits: Trust minimization, not trust elimination.
The BOP website lists his release date as 1/14/2034 with his status as "NOT IN BOP CUSTODY".
Wow, nostalgia, it's been years since even hearing about Tucows. Tucows was a huge part of my childhood from 10 to 18 years old. Good run and great early repository for software. Thanks Tucows.
They were paying Eclipse and Java UI contractors a little less than that about 7-8 years ago. Maybe the MBAs have them all in the same bucket
This news begs a big question: How much does this new test cost? That will decide how it might be adopted.

This test requires a chip rather than a simple lab assay. If the cost of the test is comparably as low as PSA ($50) it could entirely replace PSA for screening. However, if the chip is more expensive than PSA, it still may be very useful -- as a second test after a PSA screening test reports a high number but before a biopsy.

If this new test could diminish the number of infections from unnecessary biopsies that worry policymakers, routine PSA screening combined with this test could become a low-risk no-brainer new standard.
I agree, the headline is definetly not what the research shows. See my other comment on non-neutralizing antibodies. Please change the title to the original one.
> is about 150MP

And a 42MP camera would mean stitching fewer than my 24MP camera, so easier to finesse movement in the scene.

> don't really need

When you live in a small apartment, you see the wall art close-up ;-)
This is especially true with your own hardware. Trying this kind of thing in the cloud is usually prohibitively expensive.
This is how the FDA's refusal to balance up-side risk is going to damage all of us. They're only interested in minimizing the risk from a treatment itself, and pay little to no attention to the risk from not having any treatment.

It's been a full year since the first vaccines were formulated, and it took the FDA 11 months to give the OK. That was a large streamlining of their normal processes, but not a meaningful balancing of risk, the standards remained the same.

In the meantime, the virus has had millions of opportunities to mutate like this. If we'd accepted a bit more risk, we could have significantly decreased its opportunities to mutate.

At least in this case, the virus can't mutate faster than our ability to formulate a new vaccine. Whether we can retool vaccine manufacturing I don't know. But so long as the FDA won't allow us to react quickly, the hole we're in keeps getting deeper.
I think in general not causing death in the target host is a naturally selected trait in viruses. The least lethal viruses are the ones that spread the most.

This has been observed in herpes, which has evolved to infect nervous system cells but explicitly not nerve cells in the brain (which would cause death).

So considering that, perhaps future strains of COVID will reduce their lethality while increasing their ability to infect.
D has fairly extensive windows API support, and the usual PE gubbins. Worth taking a look at
"perfect being enemy of good" is what I thought of.
Netscape ISP Homepage
Good point. It's often overlooked that distributors, who aren't publishers and don't have publisher-like liability, are also selective and are, generally uncontroversially, exercising expressive freedom in that selectivity.
>This is totally unacceptable.

And yet not at all surprising. These huge companies have a reputation for being faceless because they skimp on staffing their support teams and until the so-called "tech reckoning" have operated with virtual impunity.
I think Craig is a pawn who's handler's goal is to reveal Satoshi's true identity.