skysight-inc/HackerNews huggingface dataset:
One of the things that EU countries do is negotiate with the the drug manufacturers. So UK in this case of Lumacaftor, didn't cover the drug until they got a reasonable price. This meant a 4 year delay in access to the drug vs the US.

> It was approved for medical use in the United States in 2015, and in Canada in 2016.[3][5] In the United States it costs more than $US 22,000 a month as of 2018.[6][7] While its use was not recommended in the United Kingdom as of 2018,[4] pricing was agreed upon in 2019 and it is expected to be covered by November of that year.[8]

https://en.wikipedia.org/wiki/Lumacaftor/ivacaftor
As I said in another comment I think it's a communication issue. I guess it doesn't literally float in front of their eyes as part of the world for those who say 6.

Perhaps a better test is how difficult someone finds these exercises:

http://www.geom.uiuc.edu/docs/education/institute91/handouts...

It's less ambiguous than the star thing.
I wonder if the reported prices are the aggregated total price for treatment? Or is it just a price of an individual procedure, excluding whatever else that normally goes into the treatment, like diagnostics, admin and nurse time, room/facilities expense etc?
Ah, so mypy supports fstrings, but not in types. So you can do

Direction = Literal["left", "right"]

But this won't work:

eft = "eft"
ight = "ight"
Direction = Literal[f"l{eft}", f"r{ight}"]

(Yes, this is super contrived, I bad at coming up with examples, but
https://mariusschulz.com/blog/string-literal-types-in-typesc... shows some realistic examples where it's useful in typescript)
One good side effect of globalization is to create opportunities to bootstrap the local economy (by whatever magnitude) and increase the standards of living for the local population and once the local economy is good enough that the wages and quality of life rise a bit, pick up and move to the next country that's cheaper and hopefully by then the local economy is good enough to support it self, at the very least better off than it started with. Hopefully in the future we would have the entire world above a certain standard of living :)
I just started using Odysee(based on/connected with lbry) and I
must say while it obviously doesn't compete in terms of content
and the front page suggests it's a popular location for
conspiracy nuts you can actually find a lot of well-known
YouTube channels on there.

In fact I'm pretty certain that if this continues it'll be able
to compete with YouTube in the long run; mainly because content
creators can just upload everything to both platforms for a
chance to reach a larger audience and at the same time have a
"backup" in case Google bans their account for a random reason.
I've seen multiple channels either moving completely to lbry or
just mentioning it in their YouTube videos with the hint that
the other platform also has their videos but without ads.
Considering YouTube has a terrible reputation when it comes to
their weird content filtering, monetization rules and completely
broken copyright strike system it might not need a huge push to
get some momentum.
The profit motive is everywhere in the medical sector, and that is a bad thing. Even if you believe in free markets, it's not easy to get the best care.

To stay cose to the eye as a subject, look at vitreomacular adhesion. Roughly two possible treatments:
- costly and complicated eye surgery
- substantially simpler ocriplasmin [0] injections

In many cases where ocriplasmin looks like it could be the perfect solution, it isn't even considered. Could that have something to do with the surgeon's incentives alignment?

[0] https://en.wikipedia.org/wiki/Ocriplasmin
I had a case today where I was comparing two sets for equality. If the range of values is large, you could xor everything together as a O(1) space check for likely equality. Result is nonzero -> sets definitely aren’t equal; result is zero -> sets are probably equal, but you’ll need to check again some other way to make sure.

Of course this is absurd if you’re dealing with anything that already fits in ram, but it’s still neat to think about.
Chart of the USD supply: https://fred.stlouisfed.org/series/M2 (near vertical line up.) This drives nearly all assets to new all time highs. Bitcoin acts as leverage on the S&P 500. It goes up? Bitcoin goes up more. It goes down? Bitcoin goes down more.

Combine that with a wall street actually buying a few Billion USD (Grayscale investment trust has 3% of all BTC now) and you have a receipe for compounding movement upwards. Ths price chart looks quite similar to 2017, with dips that are only 20% deep instead of 40%. We just recently had the first 30% dip after the 10x run up. In the everything bubble, crypto reigns supreme. Disclaimer: I'm biased.
Which of course implies that nothing will improve until the shitty state of affairs gains publicity. This isn't how it's supposed to work, you are not supposed to fuck up and then repent in public, you are supposed to get it right without putting on a show of public repentance.

Seriously, does anyone need to be told that the confederate flag or the thin-blue-line-flag-with-Punisher-logo are symbols of white supremacism? Who thinks that support of that is acceptable in the workplace?
Every living thing on Earth.

The point they're making is that life off Earth might not use DNA/RNA at all.
Making Bitcoin Exchanges Transparent
Yep. Especially for can lighting. Don't bother buying PAR13 LED bulbs, you will likely have a medium time at best.

I have about 50+ el-cheapo Feit LED can fixtures from Costco installed in my house now for over 3 years without a single failure. Previously there would be a PAR13 bulb failure at least once a month.

The downside of course is no bulb-change-with-a-stick, but since we're talking 20 minutes of pulling a ladder out every 4 (or more!) years to replace a $20 fixture vs. 5 minutes once a month for a $5 bulbs I'm pretty happy.
"Bitcoin exchanges are a vital component of the Bitcoin ecosystem. They are a gateway from the classical economy to the cryptocurrency economy, facilitating the exchange between fiat currency and bitcoins. However, exchanges are also single points of failure, operating outside the Bitcoin blockchain, requiring users to entrust them with their funds in order to operate. In this work we present a solution, and a proof-of-concept implementation, that allows exchanges to prove their solvency, without publishing any information of strategic importance."
So it's definitely not the covid symptoms, it's inversed. Covid symptoms affect primally smell, which in turn affects taste.

But i think with covid can still taste basic flavours like salt, sugar... But not complex flavours from smell.
Very interesting. Does this act like Luna Display? How's the latency
Except I don't think a single parent has enough time to properly raise a kid.
Stellar media criticism here; I'd love it if you could point out some examples of fair media with "integrity" that, in your opinion, treated "a certain leader" objectively and fairly.

I think I speak for many people when I say that we eagerly want to know your recommendations on what unbiased bastions of objective journalism we should be seeking out.
That’s why I don’t browse the web while logged in google/fb/twitter.
As I keep them in separated firefox containers
Would you please stop posting unsubstantive comments, and comments that break the site guidelines, to Hacker News? You've done it a lot and we've asked you repeatedly to stop. When accounts keep doing this we eventually ban them.

https://news.ycombinator.com/newsguidelines.html

The kind of bias you're complaining about is in the eye of the beholder. People who feel the opposite way about Apple or any $BigCo see exactly the opposite and make identical complaints, just going the other way. It's sample bias.

https://hn.algolia.com/?dateRange=all&page=0&prefix=true&sor...
It's not about just randomly breaking the cells, it's a normal process called autophagy where damaged cells are being recycled to be replaced by new ones. This happens all the time, but it seems that fasting can increase it significantly. The leukocyte count only temporarily falls, and then gets back to normal. This is extremely beneficial to chemo therapy patients because chemo damages cells, suppressing the immune system as a side-effect and also makes people feel very sick. This can reduce these effects.
As long as it's framed as a way to cut off immoral right wing extremists from the financial system, Silicon Valley will enthusiastically embrace dystopian government control of currency.
Absolutely. There’s nothing like guaranteed money or power to corrupt people.
I like this idea! It's like a mini version of the Brown M&M Test.
You can find the main changes over the last version in the first chapter of the specification: https://bugs.otr.im/otrv4/otrv4/-/blob/master/otrv4.md#main-...

Quote:

- Security level raised to 224 bits and based on Elliptic Curve Cryptography (ECC).

- Additional protection against transcript decryption in the case of ECC compromise.

- Support of conversations where one party is offline.

- Updated cryptographic primitives and protocols:

- Deniable authenticated key exchanges (DAKE) using "DAKE with Zero Knowledge" (DAKEZ) and "Extended Zero-knowledge Diffie-Hellman" (XZDH) [1]. DAKEZ corresponds to conversations when both parties are online (interactive) and XZDH to conversations when one of the parties is offline (non-interactive).

- Key management using the Double Ratchet Algorithm [2].

- Upgraded SHA-1 and SHA-2 to SHAKE-256.

- Switched from AES to ChaCha20 [3]. The RFC 7539 variant is used [16] .

- Support of an out-of-order network model.

- Support of different modes in which this specification can be implemented.

- Explicit instructions for producing forged transcripts using the same functions used to conduct honest conversations.
I've learned to be suspicious of someone's reputation when I don't know what they've done to earn it. Everyone thinks Google employs the best engineers on the planet, but I suspect the reason most people believe that is just that everyone else does. How many people have actually come to believe that because they've done their homework?

Google is an ad company. Their entire business model is based around manipulating public opinion. Don't trust a word you hear about them.

Decide for yourself. Do the products Google makes look like they are made by the best engineers in the world? In my case, the answer is a resounding no.
Ford closes German plant for 1 month as global chip crisis worsens
I think this is a bit of an oversimplification; there are places where the out-of-pocket price ends up actually cheaper than the negotiated insurance price, which is mind-boggling to me.
> Hilbert’s 13th problem asks whether seventh-degree equations can be solved using a composition of addition, subtraction, multiplication and division plus algebraic functions of two variables, tops.

Later in TFA, there's mention about how everyone thought the 13th problem was solved in the 1950's, but in fact wasn't, leading to this renaissance of thought for this Hilbert problem. It's wild that these unsolved gems are still out there, waiting to be finished!
It's been used in the real world, on the Cambridge Z88, ca. 1987:

https://www.cl.cam.ac.uk/~jrh13/devnotes/all.html#sec218

This XOR-list trick was mentioned by Joel Spolsky in "The Duct Tape Programmer" (2009), discussed recently here.

> They have to be good enough programmers to ship code, and we’ll forgive them if they never write a unit test, or if they xor the “next” and “prev” pointers of their linked list into a single DWORD to save 32 bits, because they’re pretty enough, and smart enough, to pull it off.

https://news.ycombinator.com/item?id=25715414

and this comment pointed out the real world usage:

https://news.ycombinator.com/item?id=25718147
None, this person is apparently complaining he was blacklisted from Patreon.
It was actually not her, a Russian entrepreneur founded Badoo, then wanted more apps and ask W to join. Everything was provided to her, money, tech, marketing, etc... then the founder sold to BlackStone and the narrative changed, but. that's absolutely not how it went
When people say "I've nothing to hide", I usually say it's just like closing the curtains over the windows of your house. You may have nothing to hide, but you still want privacy. It makes sense to most people right away.

I don't remember, but it may have been Snowden that said something like that in one of his early interviews.
Perhaps first deploy a highly contagious virus specific to humans that causes infertility but otherwise no symptoms. That would spread widely before detection. Followed by a highly contagious deadly pathogen that can be transmitted by any mammal: a vector that will kill tribes in remote forests that are out of contact with civilisation.
Fastmail is my de facto email now. As for HEY, even though I paid them ($99!) I am primarily only using them for newsletters right now - one could say this is overkill. Basically, I really liked the philosophy of HEY (saw some videos by Jason Fried and DHH) so I wanted to give it a try as well as support them with my wallet.
Be aware also that the federal government immediately increments the "doses given to state" number, while states may not report the "doses given" number back to the federal government promptly, so seeing one number being much larger than the other isn't necessarily proof that there's a distribution problem
Probably not even worth the time he invested in looking for the bug or writing the post. And is basically nothing compared to the value of "exploiting" this bug.

I would've expected at least a job offer or public praise for his offers. No wonders bug hunting is not attracting enough people.
> We track general usage details, including command invocation, build process status updates, performance measurements, and errors.

Sounds like spyware to me to do that without opt-in. Projects that do that wont take your privacy seriously.
This is the issue with most small population medical research, or research that's worthwhile but by policy difficult to commercialize.

"Sucks to be you" tends to be every non-sufferer's response.
MRI in Mexico cost ~$200 USD ( https://www.chopo.com.mx/zapopan/estudios/resonancia-magneti... ) and is way closer than Brazil.

There are laboratories even at walking distance of the USA haha ( https://www.google.com/search?tbs=lf:1,lf_ui:4&tbm=lcl&q=lab... )
Biden’s Covid-19 Plan Is Maddeningly Obvious
Developer-Led Landscape: 2021 Trends Foretell New Approaches to DevOps
"More speculatively, being able to use natural language to supervise or give feedback to automated systems that have little to do with NLP seems very very useful."

I agree with this, and it isn't entirely speculative. One of the most useful applications I have seen that goes beyond googling is generating css using natural language. ie, "change the background to blue and put a star at the top of the page". There are heavily sample selected demos of this on twitter right now https://twitter.com/sharifshameem/status/1282676454690451457...

This is definitely practical, though I wouldn't design my corporate website using this. could be useful if you need to make 10 new sites a day for something with seo or domains
Indeed when ACA was passed, it was acknowledged that it was intended to reform access to health care, not the cost of health care. It was a compromise that appeased the insurance industry.
Show HN: Infinity Bookmarks – Extremely light bookmarking
Am I reading it correctly that this forwards from your custom domain to somewhere of your choosing, but then you still would need a gmail or hey or whatever to receive / operate as web interface?
I honestly don't think you'll find a course that covers this. The SO devs (and others) have kept a blog going for years with the type of information you're after. The search term is "mechanical sympathy."

Language/framework also matters. You're not going to pull this off with a backend based on a framework that gives no damns about performance. Rust, C# (bleeding edge), Java and C come to mind as good candidates.
Pointing to thermodynamics is the same "bootstraps" mentality you see elsewhere, just applied to food and health instead of money.

Just like telling the poor "just make more money", it might technically be true but it is such an unhelpful and useless thing to say, that it is hard to believe the speaker is trying to help and not just make themselves feel better.

So I don't think it's physics, I think it's some people just enjoy pretending systemic effects - inequality, privilege and just blind luck don't matter.
Hmm, I would have used + and -, I suppose. The sum of 1..n is (n*(n+1))/2. Subtract from that all numbers in the array and what is left is the missing number.
This is absolutely satire, to make fun of the trend that everything nowadays is "as a service" (even when the process can be trivially done by yourself).

Related: /dev/null as a Service: https://devnull-as-a-service.com
https://www.amazon.com/Cablecc-Virtual-Headless-Emulator-192...

Is one option
Your linked comment only quotes excerpts saying it's implementation-defined, rather than undefined. Can you point to the part that is undefined?

(You would use a uintptr_t for the xor'd prev-next pointers instead of void*.)
Or,... just ask a local?
They can be extremely helpful IF your needs are in line with the needs of the company, but if your needs are not then they're not going to be so nice.
Right, it's definitely goof that you cited it being fake, but I think the parent was pointing out the subtle (and likely unintentional) irony of discussing fake news while providing _fake_ numbers to support your opinion.
I think the issue is rather the visibility of the nonsense, as a global species we are still adapting to this new communication medium
The Covid‐19 insidious trick: Subjective perception of numbers (2020)
"team of automated googlers" where google is baked-in. Google results, and content behind it, changes. Meaning, GPT would have to be updated as well. Could be a cool google feature, a service.
Tales of Favicons and Caches: Persistent Tracking in Modern Browsers [pdf]
Apple sued for not removing Telegram from App Store far violent content and hate
My wife and I just did this. I've been using a custom domain for years, so it was just a matter of changing MX records to Fastmail. My wife only used her @gmail address, so it was a bit more involved. Essentially:

- Set up new email at your service of choice

- Import whatever old email from gmail that you want to keep

- Go through whatever list you have (password manager, your brain, etc) and update email addresses (as a bonus rotate passwords while you're at it)

- For a few weeks, regularly look at both your new and old email. As something comes into gmail, either unsubscribe or update your email for that sender, and delete it.

- A few weeks later, nothing remains to switch over (at least nothing of importance).
Venmo for Business: Free until Apr2021 then 1.9% + 10¢
Good question. It is clearly subjective. We review our subscripts periodically and agree on what we don't enjoy enough to keep paying for.
Right but the biggest country in the EU isn't ~330 million people from about a half-dozen fairly distinct cultures. Remember that the US has cultural representation from many European countries and also quite a few non-European countries.

I'm not suggesting that Italy or Greece or Germany are actually homogeneous culturally but with smaller populations and significantly less immigration than the US I suspect that the variances are smaller and perhaps more surmountable.

Germany's population (83 million) is only about 1/4 of the US and as you go down the list the countries only get smaller.
My sides are splitting. This is the lighthearted use of technology that I live for. Thanks for making my weekend, OP! And now to find good subreddits to target...
Sure; they'd probably apply strict scrutiny [0]. In the USA, speech is typically protected by default; the burden of proof is on the prosecution to show that the speech was harmful.

Seriously, have you never heard an angry American yell that they are frustrated with the status quo and would like to "burn it down" [1]? It is a common refrain and generally taken as a hyperbolic statement about the speaker's dissatisfaction with the actions of the government.

Finally, if you're in the USA, you have the right to a trial by jury if you're accused of crimes [2]; you do not need to worry that some appointed judge will find your speech harmful, but rather that a panel of your peers will unanimously agree that your speech is harmful.

[0] https://en.wikipedia.org/wiki/Strict_scrutiny

[1] https://en.wikipedia.org/wiki/Burn_It_Down

[2] https://en.wikipedia.org/wiki/Sixth_Amendment_to_the_United_...
The xor swap truck is rarely better. It causes pipeline stalls, and so is likely to be significantly slower than the trivial swap. The temporary storage will be in a register, so it's (usually) not causing memory accesses.
It's complicated so nobody really knows. I've seen a few studies that have showed real but modest effects (2-5% decrease). The benefits tend to be concentrated because most healthcare spending is on patients who don't have an incentive to be price sensitive.
A nother comment mentions indigenous Australians.

Who, if I remember correctly, are estimated to have settled about 50kya. There are later intrusions into the peninsula, as it were back then. Oceania was settled even later by boat. The language divide in Australia is overwhelmingly that of earlier indians (if you'll excuse the pun, the land bridge was connected to the Indian subcontinent), with other language families mostly limited to the north end

This I think might strengthen the argument significantly.
> points to the idea that it takes a surprisingly small number of emotionally stable adults to help kids get through chaotic circumstances.

I am not a native speaker, but to me he clearly suggests with takes that it should be possible for every case.
You’re right of course, I had overlooked the header and misinterpreted the title to refer to the present rather than to the past.
Sad and funny at the same time. Indeed, that is where Google's real leverage comes from.
Doesn't change the fact that half of America is racist as fuck, and would rather vote for psychopathic egomaniac and narcissist than for the other guy because "Dems are communists" or other propaganda pushed by FoxNews and the right media.

Look no further than your own backyard. FoxNews strikes the flames on the far right, and liberal media strokes the fans on the far left. The country has never been more politically polarized.

The moderate electorate has no choice but to go with a single issue from the far left or far right that mostly matters to them.

The amount of disinformation on social media doesn't help, but it's not the only source of disinformation. Trump was right to call news Fake News, in the sense that media doesn't report facts anymore. The majority of their programming is "Opinion" based with extremist hosts, especially on the right.
PyBOMBS is probably the best way if you want to be able to handle out-of-tree modules. If you just want to play around with the built-in functions, using a prebuilt binary from a package repo is the easiest.

https://github.com/gnuradio/pybombs#pybombs
I think you have a typo in the first introduction popup. It says BSD instead of BFS
Every bounty bug write up I've seen on HN was after it had been long fixed, so that should be a given when you see a write up like this.
Just to show I wasn't making empty promises, I am now also feeding ADS-B Exchange:

https://www.adsbexchange.com/api/feeders/?feed=ndZezh8wKD8NV...
Any idea why it didn't?
And of course the FTC doesn’t care about the blatant anticompetitive behavior by hospitals.
Touché! The best justification I can offer is that Apple is, by far, the better of the many FAANG evils?
Privacy also protects you from retroactive persecution when ideas change. Many people grow more wise over the years but engage in foolish activities when young that have limiting effects later in life.