skysight-inc/HackerNews huggingface dataset:
There is 3 maybe equally important components in the new RNA vaccines:

Protein: The final product.
mRNA: the information carrier.
Lipid bubbles: carrying mRNA into the cells

This article is about the protein. The unmodified virus spike protein is stable only when attached to the protein shell of the virus. These people worked on methods, on how to modify the spike protein so that when it's released alone, without the rest of the virus, it still keeps the same shape and form as when attached to the virus. If you just used to original protein sequence without the rest of the virus, the spike protein would fold into different 3D-shape, and would not work as an antigen. Without this work, the vaccine would not work.

Katalin Karikó invented how to "mask" this foreign mRNA, so human cells accept and use it for protein synthesis. Whereas usually human body attacks foreign RNA vigorously.

The there is the part, where mRNA is packed inside tiny fat bubbles, so it can be transported into human tissue and cells. I think we still haven't seen a submission about this technology here?
> I could not model/implement an Object with an internal state changing method in a fp language via a functor.

I don't think anyone claimed that.

> I could implement functors at least partially with an Object with an internal state changing method.

Now we are getting somewhere. You said partially, what features are being left out?
Created a shell utility in Go, called go-live. The idea is that you start it in a directory, and then those files are immediately hosted on the network.

The core idea is to be as lightweight and performant as possible, and to do one thing only and well - Unix style.

https://github.com/antsankov/go-live

Looking for contributors and feedback on it.
Your respondents don't seem to have realised that you are being sarcastic.
I am building standardized and modular mass-distributed DNA toolkits.

Two blog posts for context:
https://blog.libredna.org/post/cheapdna/
https://blog.libredna.org/post/sporenet/

Website offering version 1:
https://www.sporenetlabs.com/

I pretty much figured out (after quite a few years) how to distribute DNA for 100x-200x cheaper. Right now, I’m building DNA toolkits for engineering every different organism (it’s expensive, but I’m doing it in collaboration with other companies). All open source, too.

Imagine if you could get a toolkit to engineer literally any life form for less than $100. It’d be super cool!

The “money maker” here is that my DNA foundry can build DNA together from my toolkits quicker and cheaper than anyone else, which is attractive for new companies who want to engineer stuff using my toolkits.

It’s a work in progress, but I’m actively working on it, and I’m ramen profitable from my B2B part. Good times ahead!
The area around Indonesia is the new Bermuda Triangle (yes yes, while noting that there was nothing significant or statistically significant about the Bermuda Triangle)
I recollect a New York Times opinion piece called "Yes, We Mean Literally Abolish the Police."
>we reserve the right on when to focus on the political or non political aspect

This is a perfect illustration of the privilege I was talking about, thank you.
ofcourse you are right,

i meant 2 decades :)
> Isn't the point of sanctions to make the offending product so expensive that other options become more viable?

The key word here is other options. Are there any?

China on other hand has many other options than the US market. They will have no problem redirecting things like household goods, and other light industry products to other markets without impact to its industrial capacity.

That's what has happened in 2008, and indeed worked marvelously for them in the end.

When the American economy was flopped, they simply took all those luxuries destined for sale to America, dumped them on developing markets, and adjusted quality-quantity balance for this target market.
https://github.com/Tade0/emergency-poncho

This is a HTTP mock server for reproducing issues on the front-end using a recorded HTTP archive(*.har file).

The gimmick is that for a given endpoint it stores all the responses and serves them in a round-robin sequence.

This way you can simulate situations where e.g. a request has been retried after the JWT expired, or something special happens when an item is added to a list, and the list is refreshed afterwards - basically every case in which you need backend state.

It works... sometimes. Each new project I'm in uncovers new issues.

That being said with the test team giving me both videos and *.har files of the bug reproduction I was able to solve a few long standing bugs in one legacy system.
https://github.com/ivaaaan/smug

A session manager for tmux. Not that fancy like tmuxinator or tmuxp, but pretty decent.
I did something like this for a middle school science project. I got some friends and measured our heart rates playing different kinds of games. Found that more fast paced games like Fzero X overall hard larger increases on heart rate than more chill games like The Sims (unsurprisingly?) The scientific methods were questionable though.
> No need for JavaScript or any other complicated backend or client-side frameworks. I can use PHP to introduce dynamic elements to the page, but that's optional.

This isn't the same "dynamic" - the author must know that JS can provide interaction without a page refresh; PHP (alone) cannot.
People need to think intelligently and everything requires context.

There are 1000 random people at an event, there's no doubt that there were a few ANTIFA interlopers there, but that doesn't really mean anything.

A single cop 'opening a gate' doesn't mean much either.

Neither does the Republican guy who tried to prove electoral fraud by himself, committing a single act of voter fraud.

Most of the mainstream media is highly credible. Biased - but credible.

The fact that a few individuals maybe planned on doing something 'really crazy' doesn't actually mean there's a larger movement there either.

That's why we depend on the press to try to get a generally factual and broad view of the situation. Watching a mix of CNN, PBS, Fox, NBC etc. will give most people a rounded purview of the situation, even if there is a lot of bias.

Watching Fox since the election has been a very interesting experience because they cannot support Trump's false claims they have to have 'integrity'. But what some of them are doing (Ted Cruze as well) is saying 'people feel the election was stolen and they have a right to be heard' - basically they've taken the line of sympathizing with people who are angry, though they full well know the anger is based on absolute falsehood. Fox has been losing viewers to OAN where they take a 'hardcore Pro-Trump' position no matter the facts, which is what many want to hear.

On many Fox articles, the comments are split 50/50 with many hating on Trump, many supporting him. OAN and Breibart however, it's full on Trump. The language is scary, many calling for violence against Pence etc. as a 'traitor' for literally not committing Sedition and overturning the election on behalf of Trump.

So 'the truth' is going to be a real problem for the next little while.
A Marxist Analysis of the iPhone (2019)
A well thought out reply, thank you. Haskellers would typically agree with you. Unfortunately harry8 who you were replying to isn't one. He was being sarcastic.
Front-end developer with 2+ yrs of experience.

Location: surat, Gujarat, India

Remote: Preferred

Willing to relocate: Not now

Technologies: Reactjs, React-redux, React-hooks,
ReactStrap, Typescript, Angularjs, Angular8, Firebase Integration, HTML, CSS, SCSS, LESS, SAAS, JavaScript, Lodash, Jquery, psd to html, Material-UI, Asana, Git, Github, BitBucket, Axios & Third-Party API Integrations.

Resume/CV: https://www.linkedin.com/in/khyati-bardolia-861b52141/

Email: khyati.bardolia@gmail.com

I am available to join immediately.

I will serve you with :-
- Availability full time 40 HOURS PER WEEK.
- Expert level Front-end Designs.
- Able to translate Prototype, Wireframes, and Mockups.
- Aware of all the latest processes: GitHub / BitBucket / GitLab / Trello.
- Additionally I have strong communication skills, fluent English and quick/quality working style.
- I’ll provide timely updates on a daily basis.
Funny, since on HN I keep seeing comments about how the are not neutral and only fight for left-wing causes.
The sample size is small but the effect is strong, stronger than you almost ever see for this kind of thing.

(e.g. i suspect a tiny dose of antiviral or synthetic antibody would be effective for prophylaxis or early treatment. By the time somebody is seriously ill they are sick from the cytokine storm and possibly clearing the virus doesnt change the course of the disease.)
Hypothesis: Whenever you’re building it, you spend hours looking at it, and want to reduce harshness of contrast. The reader is only going to spend 5 minutes and prefers contrast as it allows quick scanning of the text.
Currently working on a few things but almost done https://checks.dev a github integrated (gitlab planned but not done) checklist for PR's, so you submit a PR and it adds a bunch of todos that need to be checked off before it can be merged.

Should be done in a week or two.
> 25+ people were killed in the riots this summer. Over $2B was done in property damage

No excuse for violence or property damage. Prosecute them all.

But keep in mind that "this summer's events" comprise over 7500 protests, all across the country, over a three month time span. And it involved multiple "sides" in various states of cooperation or opposition.

https://thehill.com/homenews/state-watch/515082-over-90-perc...
Unhide hidden Malware using sysdig tool on Linux
Modern malware hide themselves. sysdig is among top 3 tools which is used for malware evasion techniques. It reads syscalls directly from the Kernel, therefore it makes Malware life harder to hide.

Sysdig renders all the syscalls in a human readable way , saving them in a SCAP file, allowing the hunters to apply search filters among Kernel syscalls!
To learn sysdig this course from Farshid Miri on Udemy can be useful: Linux Command Line and Terminal Productivity Zero to Elite

There are many use-cases introduced in this Linux course on Udemy, which makes it different than other Linux training courses.
SafetyWing (YC W18) is hiring a back-end engineer (remote)
I am happy to see remnants of Old School liberalism still exist. Freedom of speech is a good that we should be very reluctant to rein in.
I've caught a few news here & there since Brexit started coming about GB receding from say higher foot safety/quality standards (because of US pressure in that specific article), and then some pesticides articles including this. Is this just a random noise or does generally EU has higher standard for environment & food safety compared to where UK is heading?
Keep in mind they don't even get the IP, just the (exclusive) rights to broadcast it for 7 years. I can't imagine that's worth anything close to 100 million.
.git Folder Digger – Gigger
> actual insurrectionists would've have done more than take selfies, commit petty vandalism and wander around in a daze for a couple of hours. it was a boomer chimpout.

Because they were foiled - their targets were successfully evacuated. They sought out Pelosi and Schumer's offices specifically - the ones outfitted in military tactical gear I mean, not the grandma that needed help getting back down the stairs. They built a gallows and were chanting "Hang Mike Pence".
From the manual

“special applications (e.g. animals) may require support for higher bpm values. ”

I’m curious what a non-animal heart rate looks like.

I really liked the format of the post, building up to useful working code. Thanks!
Ask HN: Twitter on Blockchain?
In the light of latest events what are your thoughts about the idea of a de-centralized social network? Absence of central authority => noone can be blocked, suspended or censored in any way whatsoever.

DISCLAIMER: I'm not a Trump supporter, godforbid. I actually agree that banning him was a necessary thing given the damage his tweets caused.

Just interested to learn what people think from a general perspective of freedom of speech.
Boxes with different colors and single char labels can work. Just have to be skinnable later.

Or stay simple color, see Surviv.io
The content wasn’t the problem, IMO. The platform was the main issue. Some of the content on there like “Most Dangerous Game” were things I was interested in watching, just not in ten minute chunks on my phone.
Couldn't read the article, going from the title alone, I don't yet have an opinion whether I think he is innocent or guilty.
Just finished watching the latest episode of The Expanse and had to severely reel back my expectation of 'spacecraft' when reading this article.
Awestruck Audio – realtime synthesized, interactive music for video games.

https://www.youtube.com/watch?v=iEC6-pBFj2Q&feature=youtu.be

Very half baked, even took that demo site featured in the video down. Intended to run hundreds of "channels" of music, each of which could support thousands of independent sessions (think cloud gaming but for audio/music).

Uses Pion WebRTC, Gstreamer, JACK, SuperCollider and a simple Golang API for converting http requests to OSC toggles to manipulate audio running on a cloud server in realtime over the internet.

Questions – is this crazy? Would game makers ever be interested in adopting a third party SDK for their music needs? What if that music had to be streamed over the wire (not baked into their console/mobile client builds)? Is the prospect of game player input influencing the sounds/music they're listening to compelling, or not really?
So... We're supposed to lay down our arms and submit to these QAnon people? Especially after they sneak into the military?
Why not link to the statement?
I don’t know anything about oil companies but it certainly sounds like more “do as I say not as I do” hypocrisy from a billionaire.

If Gates cares about climate change he should at least attempt to be the change he wishes to see in the world.

There is literally no reason that he can’t use a cleaner form of transport apart from his own comfort.
Doing these gives me a 100% guaranteed 3 day long headache.
Show HN: Visualize and Analyze Basketball Shots and Shooting Pose with ML
(This is a serious response..)

We are witnessing the 2nd fall of the Roman Empire..
I think you have the year off by one (2020) on your datestamp.
Doesn’t look like it. Every time I present clear facts contrary to peoples’ political leanings and biases, they downvote.
You can usually get a significant discount, usually to the point where the dealer loses money on the sale of you're willing to finance. In specific the finance kickback on a new car can be $2-3k+. Just make sure the financing doesn't have a prepayment penalty.
Having the list be seeded by your own thoughts means you're still sort of in your bubble. I'm talking about the (important, IMHO) use case of wandering through the world seeing what presents itself. Perhaps ordering by popularity makes sense (simply skip to page nnnn to discover unpopular groups) but that feels like it would also have downsides.
Public Opinion
Reminds me of when I was a kid. We left the grocery store, unlocked the car with a keyless remote and got in. My dad put the key in the ignition and couldn't turn the car on. He was confused, I was confused, I had felt a general sense of wrongness. Looked around and noticed, this wasn't our car. Same Make, Model, Year and Color and the keyless also matched, though the interior color was different. Our car was two cars further down the aisle. The chances of that happening are so very slim, but also not.
This is really cool. Are you planning to add different sports? Would love to see Hockey.
> as long as it does not indicate an "imminent" threat.

You missed a pretty pertinent qualifier here, but that was interesting, thanks for sharing.
You mean the prior existence of the fairness doctrine. The fairness doctrine was abolished with general support.

> Reporters argued that they, not the FCC, should make decisions about balancing the fairness of stories. They believed that the fairness doctrine had a chilling effect by deterring them from tackling controversial issues rather than worrying about whether they could meet the FCC’s fairness standards.

> By the 1980s, the fairness doctrine was losing clout. The deregulatory nature of the Reagan administration and the technological advances that were rendering scarcity arguments moot combined to pressure the FCC to abandon the doctrine. In 1987 the FCC formally abolished it.

(from https://mtsu.edu/first-amendment/article/955/fairness-doctri...)

The fairness doctrine only ever applied to broadcast media, it never applied to cable or print media, which FB and Twitter are conceptually much closer to. Nobody ever (seriously) argued that a book publisher should be required to print rebuttals to a recent title. Nobody ever (seriously) argued that cable media had to follow the same pre-1987 FCC guidelines.

So, yes, I would say that attempting to apply a policy (and note: policy, not law) that was abandoned more than 30 years ago to internet messaging systems is a niche view.
Fantasy card game to learn PHP, Javascript, C#, Python and Java. Decks are already for sale but I still have A LOT to do on the website to describe them nicer and better: https://summonthejson.com/
Look up the Portland protests from earlier this year. Hundreds literally stormed a federal building attempting to light it on fire, throwing fireworks, Molotov a, and other objects all-night. The protesters dressed up in outfits with gas masks, helmets, lasers, and much more. That building was some how protected from people but the capitol building couldn’t be? Not only that but it was literally not on any of these major news sites anywhere. The mayor literally went out to protest with them yet nothing happened to him. No bans, nothing. But some how here the death was by the police shooting the protester and some how this is violent? I’m not kidding look up Portland courthouse protest, it is mayhem for months but no one cares because it wasn’t the right party.
Coup: "a sudden, violent, and illegal seizure of power from a government."

Need not involve the military.

A group of people seizing control of a government, outside the bounds of regular authority is a 'coup'.

What happened on Capitol Hill was nearly a 'coup' it's clear that was the intent of at least a small group of those individuals.

The ongoing attempt by Trump to declare the election illegitimate on the basis of lies and fabrication, is effectively a coup.

As Capitol building was overrun and Senators were in hiding in the chamber, Trump was on the phone with several senators, urging them to stop Pence's count of the tallies.

This is pretty much how coups happen in places like S. America, Africa, E. Europe etc. it's pretty shocking.
Readable Bash Scripts
We'd rather have cheap sweet things than expensive sweet things. Then we'll come up with a cheap solution for the consequences that causes even more problems, and on and on.

It seems like most of the problems we have as a society are because we choose expedient solutions rather than careful solutions to problems.
I think what falls more on the left is caring that the drone strikes kill 90% civilians.

The right is much more inclined to agree with the characterization that it's mostly terrorists we're killing or that why are civilians around them.

To what some on the right might object is why are we spending all this money on this, which they might even arrive at ultimately the same conclusion as the left but for a different reason.
> Sometimes there are a lot of people that experience part of the story that there can be multiple versions of the truth, each seemingly different, but all still fitting in with a larger narrative.

This also applies in families, in retelling of historical events.

In addition, the capability of the story teller to enthrall can cause their version of the story to be weighted more strongly than others.

This can lead to a situation where the story told by the better “showman” gets an outsized credence.

Beware one person’s recollection, and recall that extemporaneous notes are the next best thing to a recording because it is that hard to remember what happened.

If your goal is influence, you must be at least as good of a story teller as someone else talking about something you have a memory of.
Nazi.
“actual insurrectionists would've have done more than take selfies“

Perhaps they would have if the evacuation had been unsuccessful, or if the certified electoral college results had still been around.

Restraint and appeasement are two different things.
Nice idea. I like the focus on simplicity, and you could sell this as Docker container to folks who don't want to be on anyone else's cloud (e.g. salesforce.com).
Reading Dracula in Real Time
I've built the simplest static site generator. https://github.com/eguneys/jener
I'm building a simulator for analyzing and designing software delivery/ops/devops systems. The idea is to have prebuilt models for tools like GitHub and Jenkins, as well as models for human processes like approvals. The user can then easily build no-code simulations of end-to-end software release processes, and get quantitative insights from running those simulations. The app will eventually use discrete event simulation and advanced analysis (graphical), but currently its just some basic placeholder "function modeling".
https://softwaredeliverysimulator.com/
It's mostly CCP propaganda though if you actually talk to HK people and see how the majority of them tried to work within the system to "make the change" since the early 90s and fight for what was promised in the Basic Law[1] which was drafted by a committee with 36 representatives from China and 23 from HK. It promised that the Chief Executive of HK and its legislative council to be formed by an election.[2]

The Chief Executive election has been delayed for 2 decades requiring the CCP to "pre-filter" candidates which the public rejected.

The legislative council election has been controlled by disqualifying candidates as well as the mass arrest of 53 pro-democracy candidates for simply organizing the primaries and engaging in debates. [3]

TLDR;
China wasn't as strong in 90s so took a softer stance. Later decided to go back on its words so had to find ways to control the elections or the results.

> No real death in over an year of violent protests by police firing in Hong Kong vs 5 deaths in capitol building siege speaks volumes about the professionalism with which Hong Kong police handled the protests.

This is not true. After witnessing the 2019 movement and the real police behavior captured on live tv/news[4], I have a much better understanding of the Stanford prisoner experiment.

[1]https://en.wikipedia.org/wiki/Hong_Kong_Basic_Law
[2]https://www.basiclaw.gov.hk/en/basiclawtext/chapter_4.html
[3]https://en.wikipedia.org/wiki/2020_Hong_Kong_Legislative_Cou...
[4]https://tl.hkrev.info/en/police-timeline/
Gab ripped their federation code a while ago. Also, when they were federating, they never cared much about properly federating. They used federation as an argument to switching platforms but they didn't care about it. What they cared the most, I think, was the client ecosystem of Mastodon/…. Gab clients were banned, but Apple/Google cannot ban fediverse clients.
I don't think I've lived in one place that long ever in my life. This is some amazing engineering, considering everything I own breaks after about 5 years.
At the beginning of the Pandemic I wanted to get more familiar with React Native, so I made the motorcycle maintenance tracker app that I always wanted. I finished it in April and have been using it myself since then. I finally released it over the summer: https://pirsig.app

It's definitely half-baked because its missing a lot of features. But it works perfectly for my use case which is all I really wanted.