skysight-inc/HackerNews huggingface dataset:
I think early data showed that you still get ~60% protection with the first shot (or was that for the Moderna vaccine?) Still, you get some level of immunity, booster only makes it higher.
There are some indications in animal studies for Moderna and Pfizer, and some preliminary data given by Moderna at the FDA meeting about reduction of transmission, but it's nothing definitive.
Congrats on the launch! This looks like a great project and I'm sure you learnt a lot from building it.

Some first impressions:

1. You used Pinterest as an example link in the guide, and it wasn't immediately clear how this was differentiated from Pinterest. If you could think about why it'd be better to use SeeLink rather than an existing tool, I'd be more interested in it

2. I think the red block colour you're using is too much (#FF0004). I'd consider changing it to a lighter red, or even white background with black text (it'd be easier to read)

3. It wasn't clear to me what the bookmark icon does – haven't I already bookmarked the link by adding it to my board? Is this feature for further filtering?

Overall, great job! It looks quite polished and I didn't see any bugs.
It sounds like this has been largely debunked, based on the research cited in The Honest Truth about Dishonesty https://www.amazon.com/Honest-Truth-About-Dishonesty-Everyon...
Well, if this due process means some opaque process that government employs to put people in those "camps" then by literal meaning there is a process, and it's done through that process.

Yet I'd say that's very different from due process that we'd like to call it. In the very least the process itself should be well-documented and published, even if specific cases files are not available online for everyone. That's the very reason why the government called it re-education camps, because the government, even in Chinese context, should only act in the framework that laws defined, and in this case, they are not.

I suspect that the Chinese government and the local Xinjiiang government expected criticism, and they are well-aware the policy is not ideal or just, and that's why they wouldn'put it into laws, because they are well-aware it would be impossible to pass. Since they can't identify who's terrorist, they round up every likely target, and put them under surveiliance just for caution. It should be said it was effective in achiving their goal, and they are aware of the collateral damage, but it's the cost they think they can afford.
Please bury this communist shit.
Slashdot reference?
How does UBI work with different costs of living? Do city dwellers get more than rural folk?
> that it’s the only way to achieve at least some herd immunity before summer.

They could have let young healthy people live their lives as normal, as the virus barely affects them. Keep them away from vulnerable people (who could be put into some of the unused hotels for example) and viola, you have decent levels of herd immunity without the expense and destruction of civil liberties. Instead we drag this thing out as long as possible.
Yes - "The Road to Reality" by Roger Penrose.

It's really hard going for a non-physics person. I tried to read it end to end once and spent 9 months on it, I subsequently tried to read various interesting chapters out of order and didn't come away feeling that I had mastered the material or thinking. But it's all there, if you are able to crack it open.
their website has a good explainer of the differences (uses 2 different adenoviruses, which are also different from the ones the AZ vaccine uses): https://sputnikvaccine.com/about-vaccine/

Their Phase 1/2 results were published in Lancet[1], which also printed an opinion about the politics of the vaccine[2]

They have reported their final data for their phase 3 study in a press releace which states they will be published in a journal soon [3].

1. https://www.thelancet.com/journals/lancet/article/PIIS0140-6...

2. https://www.thelancet.com/journals/laninf/article/PIIS1473-3...

3. https://sputnikvaccine.com/newsroom/pressreleases/the-sputni...
Sisense is pretty cool and you could connect up a bunch of different datasources
We live in a street named 'ms x of y' and someone renamed our street to y. As there was anither street called 'z x', deliveries were always going to the wrong street, or marked as invalid address.

Fixing it in OSM fixed it slowly in all drivers navigation systems and after a year no deliveries were lost anymore
> Unlike other vaccines being trialled, the Oxford team had been taking weekly swabs from all volunteers to check whether they were infected but showing no symptoms.

FTR, this only happened for one of the trials (the AZ results are actually from several trials combined) in England and Wales. In Brazil, for example, this was not done.
I love the value proposition of full stack w/ nothing but Python here. Backend has been cool enough with Python but for anything serious in the frontend, js and friends is almost always a necessity. Bridging that gap seems pretty lucrative, especially with your python → js compiler.¹

[1] https://github.com/skulpt/skulpt
Multiple factories, though one is the Serum Institute of India, said to be the largest in the world.

https://in.reuters.com/article/us-health-coronavirus-india-c...
Does this vaccine actually provide immunity like normal vaccines? The mRNA one apparently didn't stop you catching or spreading covid which really makes me wonder why it is being pushed so hard when the virus isn't actually a danger to most healthy people under 65.
It illustrates, if needed be, that handing meaningful amounts of money to all or most of the population in a recurring way is not sustainable.

The responses to the covid lockdowns, which are incredibly expensive, were only considered because they were one-offs and time-limited.

If payments are restricted to a minority, the poorest, then it boils down to what already exists in most European countries and the question is then "what's new?"

In general UBI proposals are ideological solutions to ideologically-constructed problems. They are not realistic nor practical and thus thin on practical considerations and hard numbers.
That's really outrageous analogy. Rearranging and interacting with droplets of PEG and cholsterol can't possiby have effect anywhere close to carefully and deliberatly arranging atoms into molecules in various ways to get different compounds.
"Google Maps" is just a piece of software- following it blindly, especially in remote places is insane. ~15 years a ago, Google Maps gave me same insane route up a ridge of a mountain side. I took a double check and revised my route.
I agree. And it resorts to name-calling. What's a techbro, anyway.
I think you’re significantly over-estimating the ease of keeping them away from older people.
First, a large fraction of Americans can't even understand the rule of 3, much less how they are being milked by their own government via (among many, many other mechanisms) inflation.

Second, this is a typical "boiling the frog" type of taxation, which is slow and spread over long periods of time (typically portions of whole lifetimes) and even people with enough brains to understand the problem don't really pay attention because it's never felt as an immediate pain.
I believe it's fine in Sweden
> no-one who got the vaccine was hospitalised or got seriously ill due to Covid. Whereas in the control group there were 10 serious cases and one death.

I can only imagine what it must be like for these researchers. You give some people a dummy and let them get seriously ill and one even dies.

No idea what else we could possibly do, this is probably just how this must be for the greater good, but wow must that feel horrible for everyone involved. You have to tell the family "Sorry, she was in the control group!" Peak 2020 moment for everyone involved right there.
Astra has some new unpublished data showing similar efficacy to the mRNA vaccines, and 100% severe COVID prevention.

https://archive.is/pMhDo

The UK really needs to roll this out fast because the current sudden growth in hospitalisation rates is a disaster, NHS is near full capacity again. I suspect there will be a full lockdown in January too.
the just tried to fit in numerous trials into a single trial, whereas Biontech/Pfizer and Moderna were super clear about their trial-architecture and data (same 2-dose regime, given 3 weeks apart), we seem to have a ton of small trials with different data for that Oxford/AZ vaccine. Those 1300 participants who got the half dose full dose vaccine also turned out to be significantly younger than the other group who got the two full-dose regime, making those two groups really difficult to compare (apart from the fact that they were also differing in size)

Now we have a new number out there, 90% if the two doses are given 3 months apart, does anyone here now what the trial-size was? the age distribution? The statistical significance for that finding?
One thing I think about is the quality of domination, if I may say it this way.

Someone with a better understanding is a normal authority, it might 'dominate' others in the sense that they have to follow his lead and maybe not feel it's right but in the end it's the best path.

On the other hand there are so much bad authorities that percolate through luck, appearances, bullying, networking.. and it will be 1) very clear their ways are detrimental .. sometimes almost absurdly, 2) very difficult for people below to change this.
Not this nonsense again! The problem is young people can and do mix with older generations and infect them. It's why no country has pushed this strategy.
Thank you for this. This post made me curious for exactly the reasons you brought up. I wasn't sure why being banned from one domain meant giving up on mastodon all together, and I came in expecting some post about the problems with Mastodon as a project itself, because presumably they would have known that you could just easily make an account on a different instance. But nope, they just didn't even know the ABCs of Mastodon.
L.A. was uniquely vulnerable to this Covid catastrophe. Here is what went wrong
That's such a naive way to look at it. It's not like we could've known beforehand which type of vaccine would be more effective. Some tried mRNA, other tried other techniques, and they all have to go through a lengthy phase 3 trial. This is a novel virus, and if everyone just did one kind of vaccine, and that kind failed, they we would've been fucked.

Hell, it's even more complex than that, because even given a type of vaccine, even subtle stuff such as dose size and time between the two doses seem to play a huge role, and this is again something that needs to be tweaked over time, using long phase 3 trials. I would attribute it much more to luck than actual skills here.
Trillions have been spent in the US on bailouts. You could have paid for full time care for every single vulnerable person for a year at that cost, and left everyone else to live normally.
That's one more than mRNA vaccines had been approved before the Covid one.
I believe you can get a lot of information from accelerometer data. Especially when compared with other data for the same road. Is it even used in this way?
>It is not that far of a leap to consider a timeline where all wallet addresses are simply registered and crypto assets lose their fungible quality. Assets

Monero, ZCash, Grim, Beam are specifically designed to thwart that scenario. The day what you describe actually happens, they will replace Bitcoin.
This has been on my mind a lot lately.

IMHO personal growth of the founders/leaders is correlated with long-term success. A healthy organization should be able to adapt to changes in the market. The same is true for a healthy individual. And more importantly as leader(s) of an organization - because you must lead by example. E.g. if you have a healthy way to keep your ego in check or be aware of your flaws you will be able to notice issues in organizational structures; if you're willing to change when presented with new information so will the organization; if you micromanage everything you've fixed the speed of adaptation to your own - can be good - can be bad; if you need validation you will surround yourself with people that validate you no matter what; if you twist your reality so that you're always on top those lies will seep into the culture.

It's kind of like Conway's law but more like organizations design structures (communication, hierarchies, etc.) which mirror their leaders identity/character/personality/soul...
Visual JavaScript is low code and has been used to build dashboards yazz.con
Maps have had errors since the dawn of them, yes, even the land registry isn't always right, and yes, even state as a whole sometimes can't agree on their border (i.e. France and Monte Bianco)

The right answer is for users not to be brainlessly following whatever their corpo device tells them to be the truth.
I notice I have less strain when I wear my glasses which have blue light blocking.
> Pfizer has the highest efficacy endpoint (95% at preventing infection

Cite, please. Pfizer's primary outcome measure was symptomatic infection. Only Oxford/AZ in the UK carried out weekly PCR tests to check for asymptomatic infections.
I wouldn't call 2/3rds as "only", this is quite high.
In Poland we have only ~40% that want to be vaccinated (but maybe this a result of Germany having much older population).

I'm a bit reluctant to vaccinating until I see some more tests on wider population and we could test for long term complications (e.g. reduced fertility which couldn't be tested earlier) and I'm a person that vaccinated my children (and myself) for all kinds of diseases.

So I assume there are more people like me (aside from the usual "anti-vaccination" crowd).
Off-topic: I couldn't help noticing that there is such a recurrent pattern that under every NumPy-related topic, there are fervent disciples of Julia who prophecy that the end (of Python) is nigh and you should all be converting to Julia.

But why not use whatever suits your problem the best? I use both Python and Julia in my research, and sometimes R when I need some niche statistical packages. "My language is superior to your language" is such a self-limiting mindset.
You're missing out on _Generic, _Static_assert, and restrict.

https://devblogs.microsoft.com/cppblog/c11-and-c17-standard-...
My point is that it doesn't guarantee reduction in anger or stress, therefore should probably not be prescribed as such.
Had investigated Apache Superset recently but was apparently in a to early stage for production
https://superset.apache.org/

Definitely on my watch list though!
And it's probably running on the slowest and cheapest hardware they can buy, without any monitoring.
Thanks for the keyword. Seems to be a British military jargon, or at least that's where it originated. I would have thought that operations research is the same as game theory, but the wikipedia article for operations research doesn't even mention it.
Interesting! I'm happy to see Ruby isn't going the Python route ... It seems to look a lot how https://www.gevent.org/ achieves async on Python, which I can only applaud ...
That ultimately is their choice - using money as a forcing function to get the research we want is a poor approach to picking fruitful areas of research (although not uncommon)
I believe I've read somewhere that US military had been using it for some time. Not sure what for.
I initially thought as such too, but on a previous discussion about this exact issue on hacker news I was linked to this https://securephones.io/main.pdf. Which pretty much says that a lot of your data is just stored unencrypted entirely on the phone, so the FBI is probably just dumping the info without even needing a exploit.
Half the people on this forum are being paid by it. The other half are thinking of ways to improve it, to make more money :-)
The 2/3rds already include people who in principle want to get vaccinated but would like to wait a bit more, like you. Only 1/3rd wants to get vaccinated as quickly as possible.
Keep in mind that such things are said by people who are themselves hurting. In functioning societies, the government provides material support to citizens when it halts commerce. Wealthy and powerful people choose that USA does not have such a functioning society. They are our true enemies, and they only benefit when we confuse them with people like ourselves who are in untenable situations.
As a sidenote, I don't write "import numpy as np" in jupyter notebooks (at least as long as I don't share them with others) for I have this line in my ipython startup file.
Thanks for that second link especially, this is exactly what I was looking for!

It sounds like much of the communication and release of scientific data has been bad, but in general the approach is sound and it’s likely to work well.

The same criticism about miscommunication could be (and has been) levelled at AZ, over the full-dose/half-dose mix-up.
There are various options for RNA polymerases commonly used in vitro [1], generally the error rate is considered to be "pretty low", something like 1 in 10k. An error will also have to result in a change of amino acid, which less likely due to the redundancy of the code. So any error mRNA will probably only have one amino acid changed. This could cause the resulting spike protein to aquire some new characteristic, but it's not very likely I would guess.

Also, in the clinical trials they test the actual produced vaccine, with all errors included.

[1] https://international.neb.com/tools-and-resources/selection-...
As you image, it's an old proverb, I'm quite sure it predates modern medicine.
A lot of our proverbs involve death, bodily harm and such. Not much beating around the bush over here :-))
As the story goes Marissa Mayer was "demoted" to take charge of Maps/Places group that till that point no one much cared. To keep her into "leash", she got the budgets she wanted and she truly threw herself at Maps. She went out and bought enormous amount of expensive data and eventually setup the team with more than thousand people. Until that time still no one much cared. It wasn't unlike iPhone came out and everyone woke up to maps and Mayer's efforts paid off.

After Mayer left, Google Maps has stagnated. There is not much of next horizon chase, big bets any more. Budget growth had been slowing down as well.

However, I'm doubtful Apple will ever leap from Google Maps. You don't see hundreds of cars mapping the alleys all over the world. OSM gets better but last 1-3% is unattainable for them. More importantly, Apple significantly lacks in AI/ML skill sets. Siri is still shit show precisely for same reason.
It's not just a question of paying for the care for vulnerable persons. But young people sometimes also want to see their parents at least a few times a year, even if they aren't vulnerable and can care for themselves.
> looking at current UK mortality rates. These are now rivalling the first wave

Are you sure? This is the data I'm looking at:

https://ourworldindata.org/coronavirus-data-explorer?zoomToS...

This link goes to "confirmed deaths" per million people, see also the "case fatality rate" setting. The former is about 6.8 now versus 13.8 at the peak in April; the latter is 3% versus 15% at the peak in April. There are half as many deaths and a fifth of the deaths per case. That's not even close to "rivaling it despite being geared up", at least from this data. Is this data wrong?
But it's not just a name. It's not just a statue. It's not purely symbolic.

It is who and what the FBI are! Take them at their word when they tell us this! It's so much worse than any symbol. They are out there doing their J Edgar Hoover thing with the force of law behind them! And rubbing our noses in it.
100 Days of Rejection
Sweden tried this with catastrophic end results. It's practically impossible to shield the vulnerable population from a highly contagious disease that is rampant in the non-vulnerable population - someone after all needs to tend for the vulnerable.

Swedish health system basically collapsed under the weight and after an order of magnitude more deaths than in comparable neighboring countries they are now taking to restrictions as well.

I am sure no one takes joy in "destruction of civil liberties", but we have to balance here some fundamental rights, like the right to life, with other fundamental rights such as freedom of movement and economic rights.

Also, I have to point out a glaring cognitive dissonance here. You basically just said: "let's put vulnerable people into unused hotels so we can safeguard civil liberties". Did you mean: "let's put vulnerable people into unused hotels so we can safeguard civil liberties of young people"?
That answers the recording part, but is this the abstraction the programers use? Setting trajectories manually would be hard to do while keeping them balanced, especially with moves involving legs.
That is fine until there are implications in the real world. Extremist echo chambers can convince someone to commit a physical atrocity such as a shooting or bombing.

The real question is whether or not the shooter who frequents 8chan/2chan/voat/etc would have committed the shooting if they didn’t frequent extremist sites?
Third Point tells Intel to consider shedding chip manufacturing
The Oxford-AstraZeneca vaccine has unfortunately been heavily politicized in the UK. The reporting around it has always sounded a bit nationalistic.

For the past few months, the government has been using every opportunity to justify Brexit. The vaccine approval process being one of those.
Libreddit – a private front-end for Reddit
We are happy to ignore hydroxychloroquine despite numerous studies showing positive effects (as well as numerous studies showing no effect). It seems to have been dismissed based on a study that was later retracted. It certainly seems to warrant more investigation than it received. Likewise with ivermectin. Instead we push for rushed vaccines, with nothing known about possible long term side effects

This study for example was far larger than the retracted study in the Lancet.
https://spinstrangenesscharm.wordpress.com/2020/08/28/covid1...
It is well known in the Excel modelling world and a lot of people use Excel for modelling.

I’m not sure coding these things up is always a great idea. I’ve done various types of programming over the years but in Excel you get things like dependency tracing, error checking, UIs for every components, Excel does have advantages for a lot of work. The equivalent code these domain experts produce is usually pretty awful.
They don't say it's negative, but it's certainly a limitation.
Grafana is pretty great. There are a lot of built in connectors, but its ability to query arbitrary REST, JSON, oData etc endpoints along with databases makes it super flexible for what you mentioned.

https://grafana.com/grafana/plugins/simpod-json-datasource

It has a great GUI for building queries, plus solid RBAC, great charting, and a very flexible alert system. Configure in their GUI, then get your dashboard's code in as JSON for deployment. You can also define dashboard in actual code, ie grafanalib in Python and others- which is great for DevOps. https://github.com/weaveworks/grafanalib

They have nice stylesheets ready for TV displays, but it gets really fun when users get their hands on it and can zoom in and drill down on time-series data, filter with dynamic parameters and such.
But now you have two problems...
That’s based on the value of the whole contract, which will include the costs of participating in trials, demonstrations, training, lifetime service and spare parts. There are likely to be a whole team of personnel dedicated full time to the contract for years, all included.
Assassination of whom? The result isn't exactly discreet, it's not going to be used locally to target inconvenient persons in the UK. If we're talking about conflicts, then I don't see how it's better or worse than a predator.
If this takes off, who owns it? You or Google?