skysight-inc/HackerNews huggingface dataset:
There is incredible potential out there, potentially dozens of useful treatments that are safe and cheap, and all we have to do is repurpose them.

Consider that new drugs cost 1 to 2 billion to come to market, needing extensive tests in petri dishes, cells, animals, young male human volunteers, and then mass drug trials. It is very slow and challenging work to find new drug molecules that are both safe and effective.

But, there are hundreds of disorders, we can't test all safe drugs for effective actions against all disorders. If we have great repurposing, probably through mass automation of tests and computer modeling, then we can make a gold mine of already existing gold nuggets.

This was true of dexamethasone for covid, seems true of loperamide, and could be true for dozens of other compounds already in our pharmacy and medicine cabinet. This is the biggest opportunity in drug development, and HN has technical, computational talent, so consider this area!!!
Response to the paper arguing many ML models are very underspecified?
> IMO the best reason for this isn’t even to raise funds, but rather because the rich/connected are going to do this anyways (and get away with it)

An interesting point, and one made in another STAT article [1] from earlier this month - which is linked to from the more recent article:

‘There absolutely will be a black market’: How the rich and privileged can skip the line for Covid-19 vaccines

[1] https://www.statnews.com/2020/12/03/how-rich-and-privileged-...
On Apple Maps, press on the map and you have marked the location. Err, that's it. You can also make it a 'favourite' if you want.

You're correct - no offline mapping, though it's pretty parsimonious with data
> Do you refer to the server-stack? How would that being Open Source help you when you cannot ever verify what a server actually runs?

Primarily yes, and while true - that's an extreme and a bit pointless, imo. I can say the same about Linux, which i'm on now, as i've never verified what i'm _actually_ running. Or Matrix servers i'm connected to, and what they're _actually_ running.

Yet the idea remains that something some people have analyzed is better than something "no one" (outside Telegram lol) has analyzed.

Your question feels as if we may as well all be running entirely closed source. I'm unsure why the benefits and/or supporting arguments for FOSS need to be stated here. Is there a degree of your question i'm missing?

edit: Oh and, of course, the FOSS nature is even more important in the case where the majority of Telegram communication seems to lack security. If this was a zero knowledge platform i'd be far less concerned about their serverside implementation.
>On a server with multiple VMs on a big consumer NVMe

How did you avoid the crippling performance penalty with storing VM disks on btrfs? The usual workaround suggested to btrfs users is to disable copy-on-write for VM images, but doing so also turns off checksumming thus disabling the very features that make btrfs, well, btrfs.
It depends a lot where you go. In places like Nepal OSM is often better than any map you can buy. In the Europe and especially the US, it's not as detailed as the national maps. They usually also have much better contours (drawn from aerial photos not from the space shuttle).

But still much better than Google maps, which seems very much for cars (at least outside of cities).
Anyone have any experience with the level1 displayport switches? I've been keeping my eye on the new dp 1.4 switch that is eventually going to be released. https://store.level1techs.com/products/kvm-switch-2-port-dua...

4K 120hz seems about as forward compatible as I'll need for a decade at least.
I am filled with a sense of wonderment that I have never, until now, encountered an article written as a sequence of forum posts!

(Yes, I have seen countless long comments split over a reply thread because the content was too long for a single comment/post. That's... different)

Thanks for posting (and writing) this
what exactly does the choice of frontend framework have to do with connecting to notion? why not make this a framework agnostic adapter?
would love to hear from you about this.

Doesnt react have like a massive ecosystem of integrations around this ? for example Optimizely - https://docs.developers.optimizely.com/full-stack/docs/javas...

what do you think ? i mean i dont like kubernetes...but the ecosystem is already there right ?
This reminds me of how I used to use Teamspeak with a gaming organisation I used to be part of. It was a completely different dynamic than a video call. You could "hang out" in a room, chime in when you wanted, say nothing when you wanted. It was a lot more like working separately but with physical proximity to one another. I'm optimistic that, applied to a work context and with the same norms, this could go a long way to recreating the social connection of workspaces.
No idea. I have only heard there is interest from openbsd.

At the time, Matt told them off because it's wasn't "ready for porting yet" and wanted to save them useless work.
Okay, to balance out the analogies let's say regular programming is like building a skyscraper brick by brick ;)

The idea is that to some people, having total control and building something up piece by piece comes totally naturally, while understanding and then selectively guiding a thing that has a will of its own does not, even if in some since it's more "elegant"
This is a home NAS with 50% free space, I rarely write stuff and don't even read much, yet it still managed to get super slow :( I don't use deduplication or compression, and the good people over at #zfs have failed to find anything wrong multiple times.

I think recreating the entire thing is about my only option at the moment.
ohhh, silly me!
The picture was actually link to youtube!
As comment below noted they do have payments integrated which nobody uses, however, two main issues are that: from Durov's vocal libertarian leaning stems their attempt to launch TON blockchain network (that was stopped by SEC) and also a sizable userbase proportion uses it for shady stuff (e.g., lotta Russians buy drugs with Bitcoin bought via exchange bots). Had they succeeded at this it would've brought together two sides of not only drug markets but like all kinds of shit (think everything not deemed appropriate by Visa/MasterCard) on a convenient platform with plenty of features.

Sad to see those plans gone but what else there is to expect from authorities if you're about to make their jobs 10x harder.
Don't get me wrong, I like and use Next. But from what I can understand, it's just not as complete as Django, Rails, etc. I think the fact that template is using Firebase for its storage says a lot.

Next itself does not help you with Firebase or databases or any kind of persistent storage. It's entirely left up to you. That's a huge difference from Django, Rails, etc. The same is true of auth and many other things.
Robinhood is for the general public. The general public has always been fleeced in the markets. Always. And always will be. Read any historical book on the markets, the public is getting fleeced. If you want to complain about execution or products or relationships you should get serious and become a trader, in which case you’ll immediately stop using Robinhood. If it makes you feel any better, almost every time you’re being fleeced there is a professional trader on the other side of the trade laughing at this dumb schmuck just giving their money away.
NPM displays packages with bundled TypeScript declarations
Woah, thanks! My 2020 list was topped by some tracks off kids albums which...are for my toddler!
Before the upgrade to 11, wake was FLAWLESS. Since the upgrade, every 4th or 5th time or so, I find I need to cycle power on the monitor, and then the MBP finds it and comes alive.
This may be a very unpopular opinion but I don't think its unreasonable to have a very tight control over who enters/leaves a school. It all depends on the implementation but ultimately I think it should be a parents choice. Personally I would not be opposed to facial recognition in school and I don't think there is any expectation of privacy in schools. Risks could include someone unauthorized coming to take a child out of school (e.g. ex-husband/wife)

But I'm open to change my mind and hear the arguments against it.
There is nothing wrong with the Payment For Order Flow model. Virtually every retail broker does it.

What you're missing is that Robinhood is not the only commission-free brokerage. I'm sure you'd rather have no commissions and 80% of the price improvement instead of no commissions and 20% of the price improvement.

The real problem is that Robinhood advertised they have THE BEST EXECUTION compared to other brokers, set up a Committee to ensure they have THE BEST EXECUTION, and then that Committee somehow failed to notice that Robinhood clearly doesn't have THE BEST EXECUTION because they're taking an 80% cut of price improvement, instead of 20% like everyone else.
Are you in clamshell mode, or do you use the macbook as an additional display? My problems seemed to be specific to clamshell.
Fans of any genre say this. If you don't like metal then it's all loud guitars and screaming. When you do like metal there is fractal complexity of subgenres all the way down.

Except Phish fans. For them there is only Phish.
My LG Ultrawide 5k2k monitor has TB3 and two USB3.0 ports hub on the back. I can change source for the hub from TB3 to USB B input in the back. TB3 goes to my mac. My linux workstation is connected to the displayport and usb b.

To switch between machines, I just change display and usb hub source. I do this from monitor menu right now, but should be scriptable with dpcc , I recently discovered.
I thought you were saying it wasn't clear that the fine is punitive. I quoted the comments I read that led me to believe that. If you think I was arguing in bad faith and/or that my reading wasn't reasonable, then that's of course your prerogative, even though I don't agree.
There are chrome extensions which disable the recommendations sidebar in YouTube. I recommend using one.

https://chrome.google.com/webstore/detail/remove-youtube-rec...

Not sure if this is the one I use, because I'm on mobile ATM. But it's a similar idea, at least.
Johnn Goodenough - created the Lithium-ion battery. Without it there would be not smartphone/mobile revolution and it's cultural impact.

Dr. Goodenough is researching new batteries with much higher energy density, lower environmental impact and cheaper. If he succeeds we'll have long range electric trucks, airplanes, ships and cars.
Sounds like any other AI. Surely you weren't expecting some sort of scientific breakthrough with this gag site?
I'd say my years of experience dating women with resting bitch face prepared me for this.

But kidding aside imo you're right, masks kinda covers a lot of social cues and our reduced face to face time with other people (i guess) kinda makes us a bit more rusty when it comes to picking up other non-verbal social cues
I found it interesting, though, that since this article has come out both Roblox and Affirm delayed their IPOs. It's an interesting and unusual time in startup/IPO space.
The VMs were running on raw partitions. The btrfs reporting errors was inside a linux VM.
Hi, bought the zine, it's great.

PS Separately, if you ever felt like it, it would be lovely to have a poster (or similar short thing in your style) about CSS Selectors specifically, to give to our customers. (To use our stuff, it's good to know about selectors but don't need to know about styling/positioning and such.)
Thank you for this!
It appears that it is a condition of the Emergency Use Authorization. That would not preclude Moderna going through the full approval process and marketing the product.
tries a bit too hard to be negative to really get what it finds.
Didnt read the article, my money is on javascript crap linked into the page from 200 different sites
>You're stuck in the early 2010s.

oof, I'm not even angry lol
I'm actively looking for it right now and don't see anything. MacOS user.
Look at Mann’s email trove of behind the scenes discussion.
> You're stuck in the early 2010s. For you, music's been all downhill since Kalax made Time Lapse.

I got the same thing with a different song. What's funny about this one is it's from 2017.
Wow reading discussion of music consumption on HN is so surreal for me as a working pianist / keyboardist / accordionist / educator. There’s a guilty pleasure I derive from mostly feeling unworthy when reading through HN posts about tech, you all are amazing! At the same time I really appreciate that HN is aware of your minority tech nerd preferences compared to the greater consumer population who are perfectly happy in their walled gardens. I practice tech in the same way some one casually dabbles in piano. I wish I didn’t have to be in a walled in garden but not enough time (for now) to make a website that’s not a godaddy template. The disdain for using gd services must be similar to how I feel about music industry discussion, but I accept that I’m a minority since I can see the ‘source code’ to everything I hear. But yeah pretty funny to be judged by the AI as a consumer for something that I actually use more of as a professional reference tool. I got, 2% basic, jazz-everyones-heard-of-jazz-flex-stuck-in-the-fifties bad. It also made fun of me a lot for listening to every episode of Marion Mcpartland’s ‘Piano Jazz’ that’s available on Spotify...
I'm surprised that they haven't taken a page out of Netflix's book: sign small artists that sound close enough to what's popular to their own internal record label and push them in playlists?
Edmund Clark, the 2007 Turing Award winner, has died
Thanks - I think ill pick one up and see how it fares.
I was trying to quit Reddit for years and their intentional breaking of mobile web (as well as making email address required even for already existing accounts) is what finally enabled me to.

Of course now I just go on Hacker News and Twitter instead.
You've been listening to a lot of Yo La Tengo lately.
u okay?

love some of the jokes, i wonder if they hard coded these in or what
If you go to MSN Finance page for a stock, look at the Financials tab, Cash flow tab you see the value. Price/Cash Flow is a metric that can't be manipulated like P/E can since its based on revenue not profits.
The Long March was in the 1930s. In itself, it was not particularly horrific -- just a successful retreat of the communists to preserve their forces for future fighting. 25 years later the disasters of Great Leap Forward and the cultural revolution hit China.

Is this connection strong enough to make "Long March" a horrible name? Perhaps, but I want to point out that there is a greater depth to this question that might seem at first glance.

Let's say, hypothetically speaking, that Kennedy and Khruschev were unlucky playing their Cuban missiles game of chicken: they destroyed each other and plunged the world into the dark ages. Which names would be badly tainted with this event? Obviously, Kennedy and Khrushchev, and anyone connected to the Manhattan project would be hated beyond measure by the few survivors. What about Truman? FDR? Or maybe even Lincoln, or Washington, or the American Revolutionary War? What about the scientists who figured out the fundamental laws behind atomic weapons -- Einstein, Rutherford, Bohr? Or even scientists in general?

(I guess it's easier to answer for Russia: presumably the Soviet Union period will take all the hatred. Even then, arguably the mere existence of the USSR was partly due to the ineptness of several generations of Russian tzars, as well as Germany's assistance to communists, so they could share some of the blame?)
I prefer Vue but I think both are valid mainstream choices nowadays.
For me it's the opposite, for some reason practically all Youtube recommendations outside of the subscribed channels are completely useless and I would never watch them. There are only few exceptions. It's not that the recommendations are toxic, they are just extremely bad.

The algorithm doesn't seem to be able to learn what interests me. My suspicion is that this is so because I have a lot of diverging interests that change from month to month. Still, this does not explain why Youtube keeps recommending channels and topics even when I never watch them.
Interesting - so it seems a big sur issue? Its my first dive into docks with the m1, and its REALLY frustrating trying to find one that works in clamshell.
When you say cartel telco, are you talking about the telco's the cartels have set up?

https://www.reuters.com/article/us-mexico-telecoms-cartels-s...

Or just AT&T, Verizon and T-Mobile? Is there anything that shows they have been working to limit access to the market?
Fair enough! (Aside: The performance is horrible, but I doubt it has anything to do with JavaScript being the language of choice)
Wow, a mention of Armin van Buren! I wonder how much discovery of his work is just happenstance. His track is the first thing on Google and Bing that gets thrust into your face when you search for "this is a test".

That's my default browser bar search term for checking that my interwebs are still wired up, and I've often thought that this was either genius or a really happy accident.
The point being your statement is a completely useless statement. Any ingredient can taint a dish with its own taste.
I’VE BEEN LIVING A LIE

Thank you very much for the correction.
Well, what an ironic name they have chosen for themselves indeed.

Although it leaves a sour taste, I can't disagree with what you've said.
Pages with rocket-lazy-load are generally faster.

AFAIK Rocket is a Rust framework and my guess is that the average Rust dev cares more about perf. Which would imply that perf could be more about mindset than technology.

But that's just my humble interpretation...
To me, restore is one of the most frightening commands in git. It has an innocuous name but it can delete arbitrary amounts of uncommited work without any further interaction, warnings, or confirmation.
YouTube links and embedded videos will tilt your search experience too.

The problem is that the algorithm seems biased so that one or two visits to shit causes you to fall down into a spiral of shit. That's probably because statistically when averaged across the entire YouTube user-base, shit leads to more time on the site. Shit is usually more divisive, inflammatory, etc., and negative emotions are the easiest path to engagement.

Virtually everything wrong with social media can be summarized by "negative emotions are the easiest path to engagement." Want to keep people on your site? Anger, offend, or scare them.
Their delay is part of the frenzy - to raise their offering price.
This was fun. Trigger-inducing, but fun.
Self-Hosted Literate K3s Cluster
Try disabling XFCE composor in "Windows Manager Tweaks" it fixes tearing issues.
So what about the if statements and racism? Please elaborate.
It's possible that YouTube's current recommendation algorithm actually is close to optimal for maximizing watch time / ad revenue, even if it isn't optimal for finding videos related to ones you've watched already.

I would assume that Google has tried various tweaks to their algorithm and that it is the way it is for a reason.
"OMG. Hold up. Do you really listen to Day of the Diesels by Thomas and Friends?" (sigh)
> Thanks for the comment. My piece contains half a dozen specific examples of exactly the thing that you claim it misses,

Maybe I need to reread your piece again, but it seemed like you were focusing on the grey areas to the exclusion of clearly bad behavior. And missed mentioning some rather egregious (and illustrative) past examples, like "Windows isn't done until Lotus won't run".

Concentrating on the grey areas to make the point that it isn't all black and white is all very well, but the piece comes off as saying it is all just shades of grey and that nothing is ever clearly wrong except in retrospect after the wonks set policy.

You're also, I believe, making factual seeming statements about hyperbolic hypotheticals, like Yelp only wanting Google to show links to their site and never show any reviews or summaries inline with search results. Has anyone at Yelp actually said that?

Finally, you sort of missed a trick: Voice assistants and conversational interfaces provide far less 'room' for choices even compared to the constrained screen space of a smartphone.

If we ask for Chinese restaurants nearby, we just want an answer. We might want a qualifier appended if different data sources disagree, eg. "The Golden Garden Bistro is half a mile away on foot, and is rated 4.2 stars on Yelp, but only 2.5 stars by Google. They are pretty busy right now, and reservations are recommended. Do you want more information about this restaurant?".

Almost no-one is ever going to prefer "There are 15 results within one mile from here that are open right now, how do you want them sorted?", or "Two nearby places have current promotions you might be interested in.", or "Do you want them sorted by distance, sorted by price according to Yelp, sorted by overall popularity or how busy they currently are according to foot traffic data from Google, sorted by number of reviews from Yelp or Google, or sorted by average Yelp or Google review?".

Basically, having defaults will suck for competition, but anything that requires the user to make choices will also suck, like making the user be specific in their query, or having the assistant asking follow-up questions before giving answers. Making choices available but only if the user asks for them sucks differently as there is almost no 'surface area' for affordances.

So whatever policy decisions are made in these current cases after a couple of years of litigation, they may have to be revisited immediately, and the problem is going to get much harder because for many commercially valuable purposes people don't want a list of ten results, they just want an answer, and that makes the search engine a kingmaker.
One interesting, but unsettling statistic: the RATE of deaths per miles driven has increased by nearly 25% in 2020.

https://www.caranddriver.com/news/a34240145/2019-2020-traffi...

"When you factor in an important aspect of that change, vehicle miles traveled (VMT), you actually see that more people died this year, on average, than last year. That's because VMT was down a dramatic 16.6 percent (or 264.2 billion miles) in the first six months of 2020, which pushed up the fatality rate per 100 million VMT, a metric the NHTSA uses to more accurately compare vehicle and road safety over time. Using this number, the NHTSA discovered that fatalities per 100 million VMT climbed to 1.25 in 2020, up from the 1.06 in 2019, despite the same three-year decrease that the agency saw with fatalities-per-VMT that it did with overall fatalities leading into this year."
This project takes your baseball pitching clips and automatically generates the overlay in real-time! A fine-tuned Yolov4 model is used to get the location of the ball. Then, I implemented SORT tracking algorithm to keep track of each individual ball and filter out the misdetection noise. Lastly, I have applied some image registration techniques to deal with slight camera shift on each clip.

I'm still trying to improve it! Feel free to follow this project, also check out the Todo list.
Brave allows you to sell your time/attention by showing you ads and giving you money for it. You can earn funds in their cryptocoin. Chromium, of course, does not have ads.
I’m a VC? I’ve never launched a tech product? TIL.

It’s possible you are replying to the wrong person? Today seems to be the day where people make up a history for me that I am not familiar with. I was never a VC, and the first time I launched a tech product was a compiler in 1987. Many since.
Letting a child use your account ruins it too. Even the AI noticed the horror.
This seems like a lot of work. I wonder why people tolerate this, it seems to me to be a significantly worse UX over the radio.