skysight-inc/HackerNews huggingface dataset:
Yes, I’ve read the original report upon which that claim is based. They make it utterly clear that the evidence is weak, and that genetic variants can achieve high frequency even if selectively neutral:

https://khub.net/documents/135939561/338928724/New+SARS-COV-...

This slide deck puts it in perspective: there’s a specific mutation that is increasing in prevalence in a certain surveillance network, there’s a hypothesis about why it might lead to increased spread, and it requires more investigation. That’s it. Any claim of knowledge about impact on Rt is simply wild exaggeration of the data.

This is a case where if you don’t understand the field, you have no ability to judge the quality of the claim being made. People are irresponsibly reading second-hand sources, and quoting numbers out of context. Other people quote those sources, and before long, the snake is eating its own tail.

I would wager that the author of that BMJ piece never even read the presentation I quoted above (even though it’s the cited source by NERVTAG for the “genetic evidence” claim in the brief whitepaper that the authors do cite).

This stuff is almost 100% speculation.
There actually is. Accounting is complicated because it has a multitude of rules around all this stuff.

The goal is transparency. Yes, if someone owes you money it’s an asset on your books. But there are a ton of rules around proof that you expect to be paid, when it must be paid by, when you need to write off all of it or some of it.
Ah, what would be the most common incorrect way to use it? Being a non-native English speaker I'm always fascinated to learn new things like this one.
Isn't the whole point of graph databases that they can traverse graph edges efficiently by following pointers to nodes, which relational databases can't do? Then it seems a bit strange to implement a graph database on top of a relational database like SQLite?
He's active on HN as well, his username is jsomers. He made an interesting visualization a couple of days ago and submitted the link.

https://observablehq.com/@jsomers/we-need-more-tiny-knowledg...
For security purposes as used since the early days in mainframes and big iron UNIX, surely.

As workaround for broken dependency management, not really.
I'm sorry but the 'rivals' are close to almost too late. Apple works around 3 - 4 years ahead of the competition. By the time the 'rivals' catch up with getting M1 performance on an ARM processor, Apple would already have released an M3 or M4 Mac Mini or Mac Pro.

Microsoft is probably the closest with the SQ processor in the Surface line-up but is certainly not as performant as the M1. As for everyone else, this plan to 'catch up' might as well call it a day.

The M1 chip seems to have dismantled the whole competition for another 3 years, however the development ecosystem is still unoptimised and very early. I'm waiting for an M3 or M4 Mac and when the software is fully optimised for Apple Silicon.
Whatever You Can Pick Up from Resilient Entrepreneurs of 2020
Can a person (in poorer countries) get this first and then Moderna /Pfizer a year or so later? Will the second vaccine cause problems?

Even 60% is better than nothing. Add the percentage that already passed the virus and you get a decent % that no longer get sick or transmit. Not a bad thing, for now.
I keep a list of other fantasy/game design Inspo here https://github.com/sw-yx/spark-joy/blob/master/README.md#gam...
A lot of "civilian" doctors and nurses are the military doctors and nurses, in the reserves.
Playing as a sorcerer is like an hidden easy mode. You can just hurl spells at enemies from a safe distance.
Deep down in the review sits what can be a deal breaker for some - including myself:

> X-Factors

>

> I prefer to play this game online instead of in person. First, games are significantly faster (10 minutes instead of 30, plus no setup/teardown), but more importantly, it eliminates the need to constantly shuffle your cards. If you play this game in person, you have to deal with these annoying factors, which I admit may detract from the experience. Then again, this is a flaw common to most Eurogames, so take from that what you will.

I play board games exclusively in physical form. The moment you are playing using computer, your competition suddenly grows enormously and some of your design choices become flawed (because e.g. keeping state is hard for people and trivial for computers). I don't believe board games can win that competition.

The physical form has its unique appeal: tactile experience, being offline and distraction free, no stupid sign up requirements etc.

Of course I realise there will be some that disagree with me, but that is fine!
Yeah, related to this, I wanted to comment on this paragraph on the article:

> There should be no reason to ever study a game where a beginner stands a reasonable chance of winning. I want a game that rewards experience, that permits further study, that has meaning to its replayability.

I agree with you and disagree with the article on this point. I think a truly good game must have an explicit, adjustable factor of randomness or odds so you can match different levels of players and play for fun. It's hard to balance, but that's the point of game design: rules simple enough to be accessible, but that at the same time can combine in infinite ways giving each game depth, and have the opportunity to match players of different levels without that being overwhelming.
Sounds like you are judging that exclamation points are unprofessional.
Funny Animal Videos Compilation
The usual hype curve that everyone should be using it no matter what kind of workloads.
I think there's a difference between hunting for food that's responsible and in balance, and hunting for sport or trinkets in a way that reduces 7 tribes of elephants to 4.

I agree we need brutal traits in our nature, but I also think that we can choose to use those brutalities judiciously, rather than gratuitously. This case, to me, is very much the latter, and so sad.
Fossil here, happily using VMs.
> I disagree with your general conclusion that the vaccine should not be approved as-is.

Which dosing regime should be recommended in this case?
New Haskell Foundation to Foster Haskell Adoption, Raises 200k USD
Not properly blanking your UV/Vis measurement is an amateur mistake, that really should not happen in this kind of setting. UV/Vis spectroscopy is a rather unspecific method, many things can absorb the same wavelengths. You need to have a very good idea of what is in your sample to be sure that you're measuring the right thing.

In this case there are two things that absorb at the same wavelength, the vaccine and the polysorbate. The proper reference measurement would be all components except the vaccine, which you then compare to the full vaccine. It reads a bit like the used water or another buffer as blank here, which is really inexcusable.
New California Law Could Spoil Some Growth for Food-Delivery Platforms
A cursor is either valid in a transaction, or will cache its results - either way it will give a consistent view of data:

https://www.postgresql.org/docs/13/sql-declare.html
How Tesla China Runs Its Shanghai Gigafactory 3
> You can see this in new RTS games that try something new like Tooth & Tail. It has a lot of negative reviews from RTS players saying things like "No micro?!? This isn't a real RTS!" Even though the lack of micro is specifically to try to draw in new players.

Well it's rated Very Positive on steam, for what it's worth.

It's definitely far from a standard RTS, though, with the way you have a single avatar character that runs around to personally provide vision and perform all actions.
apt/.deb unfortunately has a much much higher barrier to entry.

Docker, is simple enough to get even the most inexperienced developer going in a very short time.
I looked up culturally normative. I think it's something to do with "cultural norms", so to say something is "culturally normative" indicates that it's one of a culture's "norms". If I don't get that right, feel free to correct me, I'm interested to learn about this terminology.

Definitely my view is subjective. It's my personal feeling about it. I'm not pretending to tell other people how they should feel about it. Nor would I expect them to tell me.

I agree we are Apex Predators and that's a good thing. I just think we can use our brutality responsibly and considerately. Hunt for food in a way that respects and maintains ecological balance, to me, is different to hunt for trinkets and sport.

If the elephants are attacking villagers indiscriminately and stomping children, and the 3 tribes eliminated were genetically predisposed to that behavior, I'd be there with you all carrying my pitchfork (or musket, or whatever), ready to "keeell those darned demonic elaphunts!" But if it was just gratuitous violence for trinkets against a large, caring, intelligent and sentient species, I think that's horrible, and that the people who did it, and that side of our nature (gratuitous cruelty) makes us terrible, and I feel it's terribly sad for us and the elephants.

I'm not attacking you personally, nor saying eating meat (or killing animals for some reasons) is terrible. But if you feel people aren't terrible in some ways, I get that perspective, I just think and feel differently about it!
I wouldn’t count on it. There will always be a need to connect external peripherals, and they’ll just continue to update the spec to expand its capabilities.

HDMI 2.1 supports 4K120 and 8K60, I expect that alone will be sufficient into the 2030s.
Microsoft teams does this which surprised me. I sent someone an excel file as an attachment and they were able to edit the file inline
I can imagine how frustrated you are. I flew ~1,000 times and I've encountered about a dozen situations where I was really pissed off at some airline policy.

Two suggestions for you.

One: you might be, like me, a lucky one. Someone with an IT background, not too negatively affected by the Covid-19 crisis. Think about it for a second.

If my guess is wrong, apologies for assuming you fit that profile. Tell me more about how bad it is for you, if you'd like.

Two: you can deal with this issue by simply considering it "lost" money, and move on. Getting your real money back would be a pain in the ass. Right now, the Airline is still capable of giving you hours of rage and stress. Take away that power from them. End the issue in the fastest way possible.

It's a pity that these things happen. In a modern, just society, a company and its executives should be immediately punished for this kind of behavior.
The mistake that happened here is the kind of thing you explain to students the first time they're in the lab. It's really obvious and something everyone should know that uses a UV/Vis spectrometer.

And of course the method itself is suspect, as the main benefit is that it is cheap and quick, not accurate. And then taking the wrongly performed measurement with the worse method over the qPCR by the manufacturer (who likely has much more robust QC than someone in academia) is just insane.
There’s a lot of anti anti-depression online, bordering some sort of antivax movement.

I’ve been on medication, and what I read online about it and what my doctor and therapist say about the medication is almost completely removed.

I’d prefer counseling to medication too, but if you have doctors recommending something, generally take their advise over HN and reddit.
One improvement is the container is sandboxed and dependencies to the host must be added explicitly, eg --volume, --env, --net.

Sure you could do the same with chroot manually and there are many other tools that does the same thing, but somehow the docker way of representing these concepts are more graspable for average user, and much more widespread use.
The length of a game varies according to what the players do. If your opponent plays a slow strategy, and you a quick one, not only will your deck become useless to do anything with, but you will lose your power to control game length (as it is tied to buying cards), so your opponent will be free to extend the game length.
Personally, I don't as I struggle to remember the last time I replayed a game but I can understand how some people would be put off by this.
> One way to get around this is to drop the notion of page number. Instead do greater than last element on last page.

That's the whole point of a cursor, isn't it?

And pagination just means querying the records to return a limited subset.
Why do you assume it's not your fault?
I think those "typeahead logs" aren't actually logs, but Google suggesting that you use the faux-query modifiers. I suspect this because sometimes they make no sense.
Owncast Instances
Tenet movie review and film summary (2020)
The most effective form of SEO these days is paying for ads.
that’s crazy. Did you do P and a . over stroke for question Mark?

Or just, like thisP
Calculations over at NSF made it clear that SN8 had sufficient delta-v on the pad to reach the Karman line, if they hadn't throttled back and turned off engines as it ascended. So SN8 could already have reached space. (With the assumption that the nose could have taken the pressure of going supersonic relatively low.)

Similar calculations state that a Starship with full tanks and 6 or 7 engines might just be able to make it into orbit on it's own, assuming it doesn't have any payload or heatshield.

Since that's useless and wastes the ship, they will never do it. But it still boggles the mind that they are using a craft that is almost a SSTO ship ... as a second stage, on top of a massive first stage. The Raptor engines are freakishly good, near the top in both efficiency and thrust.
Ah! T see what you mean. Thanks for clarifying and correcting me.

I possibly have some sympathy with the anti-NAT view taken at the time, even if it ended up being the wrong thing to do it hindsight. Adding more mandatory complexity to implementors would have harmed adoption rates, and I've seen some weird edge cases with NAT64 - it's not necessarily a trivial thing to implement correctly.
That’s not the definition of reproductivity.
The only way to know is to forge a malicious script that encrypts the filesystem, slip it into a popular library, and see who complains. Otherwise people will always take half-decisions, only masking the types of attacks they know about. This, or black hats are already using this backdoor silently.

Which makes me wonder: Should dev machines be considered high-risk? They run all sorts of software, with permissions loosened, then pass programs to CI tools, which build them and deploy to prod with AWS authentication tokens enabled... I’m shaking just seeing how many Chrome extensions my devs have (with all permissions enabled of course) when they access prod instances...

Should startup management (Safe environnements with Excel, no Chrome extensions, accessing the company’s bank accounts, etc) be done on separate machines than development activities?
It varies quite a bit so I can only speak to my own experience. I've worked in both banks and asset managers/investors (which is my current role). For banking, some offices are almost purely administrative offices (maybe even just IT/HR effectively outsourced to a lower cost jurisdiction). Most will include at least some senior front office functions (client relationship people effectively), some are almost full setups including junior staff working on the corporate side of the house (eg a couple of banks have almost full setups in Madrid and Paris).

Very few markets front office people (ie traders) will be outside London though, which is where there has been perhaps most debate about who might move (though one issue is very few of those people are willing to move - some banks tried early on to move teams and found whole teams simply quitting to move to a competitor who didn't ask for that instead). This is where most people in the industry feel there is still some risk of further moves but the risk seems to be receding rapidly now.

In asset management, the fund itself may well be in one jurisdiction (usually Ireland or Luxembourg for reasons relating to tax transparency for ultimate investors and the flexibility of legal form offered, though sometimes Cayman Islands/Jersey/etc are used and very occasionally UK, Germany France etc). There will often need to be some form of local presence to ensure the right tax treatment there, but usually this is administrative/token and often outsourced. There might also be feeder entities in other jurisdictions again due to individual investor tax/legal requirements (fund which invests in the main fund or similar). Management for the funds can be across more than one office though this might often mirror the banking set up - bulk of junior find management staff will be in a single location (typically London) and there might then be a few senior staff in one or two other offices.

Early on the EU tried to put pressure on asset management industry to move full management of funds "onshore" but this is fraught with difficulty because it's very hard to write a rule which "penalises" London like this but doesn't have massive negative consequences for institutions who invest with funds managed outside both the EU and UK. I think this has probably gone away now.

Elsewhere, I believe some rating agency staff have been moved from London to the EU and there is an ongoing debate about clearing house location for some trades (at the moment that's staying in London because there isn't the capacity to do it anywhere else in the EU and I suspect the pressure to move will subside even more now).
What if your id column uses GUIDs?
Ask HN: What are the best decisions you’ve made?
Excluding choice of partner and having children, what are some the best decisions you've made?
It's sad to me that this author's only view of RTS is as an esport. If that's how it is then I'll be fine if there's never another RTS, and 95% of the public doesn't care about esports either.
My now wife was using Pinterest as a kind of memo board for preparations for our wedding.

I signed up and even after a month the UI flow was so incomprehensible I had no idea how it was supposed to work. Achieving basic tasks was beyond me.

Yet lots of people with non tech brains seemed to just accept it's imperfections and inherently unpredictable UI as normal for modern technology.
You may be forgetting a bunch of other countries that do space together, and as a group they have "the supply chain, manpower, funding, and infrastructure to build large scale commercial access to space", and are members of NATO. That said, I haven't seen as much interest in commercial space launch vehicles over here as I'd like to.
No, arbitrage is a combination of trades that essentially risk free as they offset each other.

This is just regular trading. Every time he swaps a card, he takes the risk that he won't be able to offload the new card.
Fantastic work. Using the Kindle rather than the browser must be better on the mind and the eyes. I wanted to try something similar myself using Plaid. Thanks for sharing and good job.
I don't understand your point. King plus knight v King is completely pointless, no move for either side is any better than any other. In fact the game should simply be declared a draw and no more moves should be played. What possible value does it have? Test the ability to generate legal moves maybe?
Elie Metchnikoff, the Man and the Myth (2016)
Sunburst Evasion simulation and demonstration script
Yeah I've never seen anyone go to that much effort in practice.
> P.S. The worst people are the ones who take several turns on Slack just to get to the point.

> "hi!"

> "hi!"

On that point, one of my colleagues has this in his sig:

https://www.nohello.com/
If the API takes a cursor and a number of items to fetch, the idea of a "page" or how large it is exists entirely on the client. You can fetch 40 results in one query and say it corresponds to the next four "pages", if you're configured to show ten items per page

It seems worth noting a high number of concurrent queries to the same database shard as part of the same overall page load can be very wasteful of CPU as database load increase, due to the cost of context switching. https://github.com/brettwooldridge/HikariCP/wiki/About-Pool-... dives into that.
I agree. IIRC, the atmosphere at the Earth-standard-pressure level isn't corrosive, so we could park our bases there, and there's an ISRU possibility through extending scoops (or sending drones) to lower atmosphere and siphoning some of the more resource-rich air there.
It's easier to just use a search engine that values user experience.
I'd expect they've got a LOT of baggage. They have the ex-SBC copper-wire networks they probably wish they could shed (compare when Verizon basically refused to rebuild damaged infrastructure after Hurricane Sandy). But they also went all-in on pay TV, buying DirecTV at a premium price just as cord-cutting became a thing.

I wonder if we'll eventually see an "Amtrak" style nationalization for our POTS and related infrastructure. The firms with nothing sexier in their portfolio (Frontier) are frequently unhealthy, and the ones that do have other things to sell (Verizon, AT&) don't give it their full attention. It's no longer a competitive commercial product, but it serves enough of a public interest (i. e. not breaking a billion POTS-attached alarms, the high resiliency in natural disasters) that it can't just be dug up and scrapped for copper.
You're almost there. You're on the cusp. If you're really drawn to something you'll sacrifice everything before 9pm to make that thing happen. It might not work, it might not be a good idea from other perspectives, but if your desire drives you to what you think the world needs, you'll make time anyway possible.
The problem with online gaming for RTSs (and to some degree all skill-based games) is it's unwelcoming because there is too large a disparity between casual players and those that somehow spend hours a day on it.
AOE2 variety comes from many different map scripts with many different seeds, not so much from the civilizations/units/techs.

The doc talks about map generations in the AOE2 space section, but given the rational for prioritizing diversity, I expect this the variety in map generation should lead to a higher variety score.

I really enjoying watching the AOE2 tournament scene:
https://liquipedia.net/ageofempires/Portal:Tournaments
If you look back at how they learned about landing Falcon 9 first stage - they failed many times before succeeding : https://www.youtube.com/watch?v=bvim4rsNHkQ
> Currently the only details I can find about the microarchitecture is either press waffle or things reverse engineered via timing (you can look for bumps in graphs to find the widths of various speculative features of the CPU).

Tbf, the agner fog's unofficial CPU optimization manuals[1] (for x86 CPUs) are quite good.

> Intel, like them or not, have genuinely very good documentation

Eh, depends. (Not talking specifically about optimization docs.) On the whole, I find intel documentation functions better as a reference, where amd documentation functions better as explanation.

1. https://www.agner.org/optimize/
Ask HN: Why are personalised ads bad?
The fact that targetteed ads are bad seems to be accepted as a given. However, in my naivité I struggle to grasp the rationale of this obvious truth. I hate all ads, but I kind of hate random, useless ads worse than potentially useful suggestions for products or services. Can someone help me please?
Unfortunately I was not so lucky and am at the brink of losing my job.
But yes I have long given up since I am the one who "applied" for refund via voucher by clicking. But definitely something that I didn't see coming, lesson learned.
As a counter, I have gotten 3 100+ person dev shops to adopt it.
Feature parity isn't exactly the reason to drop it....

$ is easier to type than document.querySelector and it absorbs browser differences.