skysight-inc/HackerNews huggingface dataset:
Looks very interesting! Thanks for sharing.
Oh, so gates big push to heal us all, with this convid vaccine, in the same breath says lockdowns are going to carry on till 2022, killing and starving far more than the third world coountries ever experienced. Please, this man is evil.
“In a healthy functioning society, we'd ...”

Well, in your idea of a healthy functioning society.

EDIT: the above sounds probably too harsh. But the real question is:

Why is that bad?

Take also into account that vaccinating celebs is just counting beans in the whole process.
MuZero: Mastering Go, chess, shogi and Atari without rules
Damn, stop criticizing my taste in Taylor Swift's music!
I'm very biased towards Python. I'm working on AutoML tools (created MachineLearning-as-a-Service web-service and open-source AutoML Python package). That's why I'm using Django. In my opinion it is very powerfull. There are for sure many people looking for easy start in Django+React setup, that's why I started writing tutorials.
I was looking to see if anyone caught this. It seems that Robinhood would be better for someone not investing a lot of money. If I execute a trade for $1,000,000 a small difference in stock price makes a difference and its better to pay a straight $5.00 commission with the lowest price possible. However, if I buy a single share for $50, that $5 commission is now substantial. This seems like a very clever way to compete and offer a better service to poorer people.

Unless I'm missing something the boomer either didn't catch that, or chose not to acknowledge it. As a millennial I'll assume his best intentions and that this isn't an attack on a successful company business model that he's receiving a kickback for to de-legitimizing Robinhood.
That's right---Stan doesn't have any online learning facilities. It's very hard to approximate posteriors and chain them, so we don't try.

If by "big data", we're talking about too big to fit in memory, that's right. Stan's fully in-memory. Compute can be distributed and GPU-powered for matrix ops, but all of the data and parameters and the core autodiff expression graph need to fit in memory.

For "medium data", Stan's adaptive Hamiltonian Monte Carlo sampling is much more efficient and scalable to complex models and higher dimensions than Gibbs or Metropolis. I'm fitting a Covid prevalence model using a custom trend-following and mean-reverting second-order autoregression model over 400 distinct regions with weekly data that has 5M data points and 10K parameters and adjusts for sensitivity and specificity of various tests taken. It fits in a single thread using MCMC in 24 hours or so, but we can fit the model with variational inference in a couple minutes. Although variational inference often produces reasonable point estimates in bigger data settings, it doesn't reasonably quantify uncertainty. I'm also working on a genomics model for differential expression of splice variants that involves 120K measurements and just as many parameters to deal with overdispersion of biological replicates in a control and treatment group. We're using variational inference and it fits in a couple minutes for the comparitiver event probabilities we need to estimate.
> MBAs have made sure KFC will never be as good as Popeyes.

While far superior to KFC, Popeyes has second tier chicken. It wasn't Popeyes that killed KFC as a business, it was Chick-fil-A, which has conquered the chicken fast food market in the US and will continue to bury everyone else. They have far better chicken than Popeyes.
It's a scarcity problem. We have a finite amount of doses and more importantly, ways to transport and give those doses. Many (but not all) of those problems can be solved by putting more money into the system.

One way we handle scarcity in capitalism is by charging for things. Would you be willing to let a rich guy pay $10 million for the vaccine.. if it meant a 1000 teachers could get it for free next week?

It is basically a tax on the rich except it's opt in.
The cannon, targeting system, radar, and so on, is likely to be more expensive than the number of suicide drones to destroy it.
Jesus, when did economists get so single minded? The benefits of a vaccine are almost exclusively from the network effects. It is almost purely externality. Since when are markets capable of efficiently allocating externalities? Likelihood to spread the virus does not correlate with personal incentive to get vaccinated.

There might be a market scheme for allocating the virus that does align with society's incentives, but I would bet dollars to pennies that that solution is basically just democratically elected government.
FreedomBox – Personal Server at Home
I used XFCE with this exact theme for a few months and I loved it. The only thing I didn't like was that the light gray top "outline part" of the window decoration doesn't disappear when you maximize a window. I never figured out how to fix that.
A guide to vaccinology: from basic principles to new developments
If you're a developer and someone decides to have a layout for the emails sent to customers, you probably still have to use tables.

I find that designers who create their own CSS are pretty rare. Most times I've seen frontend developers slice up designs. I think you need to have a workflow to do this properly. I needed someone to show me how to do it and I often preferred to just use an open source CSS lib like Bootstrap.
This was great, really spot on and snarky. Though there are some ambient playlists I sleep to and so it weighed those far more than it probably should, but I guess how is it supposed to know that. My spotify recap thingie said the same thing about some of the ambient artists.

> Based on your listening habits, I can also tell you your spotify was...

> stoned-itunes-visualizer bad

> cling-clang-pots-and-pans-music bad

Gotta say, that's a pretty perfect call out of my average music listening.
They do address that concern in the article.
Given the number of people I know personally who have already gotten the vaccine, it seems to me that they aren't being terribly stingy with handing it out to people.

I would expect the even moderately wealthy to be able to cut in line and acquire it whether or not they admit to it publicly.
He might be talking about the monoclonal antibody treatment that Trump, Rudy, Chris Christie, and some others have received. They gave the president 8 grams of the stuff. His was the Regeron formulation, I'm not totally sure how much that costs. Bamlanivimab, from Eli Lily, apparently runs about $1200 a vial[0] (with a vial being 700mg), so if Trump had gotten that it would have only been in the neighborhood of $20k.

And, of course, antibodies aren't made from stem cells, so I don't actually know what the poster is on about here.

[0] https://www.globaldata.com/eli-lillys-covid-19-mab-bamlanivi...
> 1930 census statistic paper from Nazi Germany

Minor point, but there was no Nazi Germany in 1930. They gained control of the government in 1932-1933.
That was interesting, thanks.

And claims that the 'special spice mix' is now nothing special at all, that would make sense, there's not a great deal of flavour in the coating on KFC - I'm sure it used to have more to it when I was younger
somewhat related: https://www.youtube.com/watch?v=IjABEqQ6YXM
> But no, this is someone suggesting celebrities and billionaires should be the first people we protect.

I don't think that's what it's saying though. It's saying by allocating ~500k vaccines (or as few as ~100k), we can raise $50 billion dollars, and show people that other "influential" people see the vaccine not only as safe, but as something that should be sought after. In the grand scheme of things, that represents a very small portion of the total supply, and hence I'd argue the upside ($50B + more people getting the vaccine) would be worth it.
That's exactly what https://github.com/silviogutierrez/reactivated does. It's a work in progress and docs are coming.

But it's the best of both worlds: Django SSR using statically typed JSX.

See for example my blog or business sites (on profile). Both SSRed by Django using React templates.

Then when the client loads, it gracefully "attaches" for dynamic interactive behavior as needed.

By far the biggest pain point is having to run node and python on the server. So I'm working on the best way to do that.
I'm not sure if you intended to imply otherwise or were just providing examples of iridescent birds, but birds are not mammals.
This is just not a serious idea. Firstly, if you do decide you want to suggest diverting the vaccine from people at high risk to people at low risk in order to raise revenue then the least you can do is run the numbers on how many more of those high risk people will die.

Secondly "this isn't political! It's either a free-market solution or a tax". No. It's not a free-market solution, it's the governemnt setting an arbitrary price for a product they have a legal monopoly on, it's also not a tax since it's entirely optional for people to pay it.

Thirdly, the comparison to Delaney is massively off - Delaney's plan would save nearly $100Bn compared to the current solution of selling the vaccine and congress being forced to hand out $2000 stimulus checks. Becuase the checks weren't really about getting people to take the vaccine, it was about providing the stimulus checks that are already going to happen, but tying them to something.

Finally, if you're rich enough to give $100k for a vaccine you're probably rich enough to find a way of getting it somewhere else, so really what we're saying is that you're asking them to make a massive donation for something that they don't need fron you.
Product Hunt: Get on Cast – find a podcast to help you grow your business
The diagram shows he is only plugging in peripherals like keyboard, mouse, webcam. For things like that, USB2 should be fine, and you save a lot of headache. If you have a high performance usb3 storage device connected, you probably don't want it to switch with your KVM anyway.
Honestly all I want is for Spotify to differentiate between music I actually like to actively listen to and music that I like to play in the background 24/7 (e.g. chill hop)
In what way is it “better”?

I tried three competitors as I moved away from Spotify, and found they were all substantially better than it.

I care about music selection, recommendation quality, and library stability (not deleting stuff from my collection).
I think a blocklist is prudent for sure, and more likely for YouTube to implement. An allowlist like you propose is already similar to the pure Subscriptions view, and restricting it to only channels related to your subscriptions would kill most of the reason behind recommendations in the first place (virality.) Not saying that's good or right, just that YouTube is less inclined to implement such a feature.
Where's Warren Buffett?
Static site deployment with 11ty, Cloudflare Workers, and GitHub actions
Given the gigantic cost of lockdowns to the economy - billions a day - the government has likely already thrown an lot of money at vaccine production and distribution. If more money could be usefully spent, it would have been.

Therefore, if an 80-year-old is 300x more likely to die than 37-year-old Martin Shkreli, moving a dose from the former and to the latter is inefficient.
I'm curious how much people would be willing to pay for this vaccine if they had to. As someone who is not in an at-risk category and who don't work on the front line, I don't think I'd be willing to pay very much.
Perhaps researchers who accepted these positions with Google were naive. That is certainly possible but it can't be argued: Google hired these people under the pretense of letting them do their research free of censorship and, now that they work for Google, this censorship is being imposed.

I'm not sure what the rest of this comment is alluding to... The posted article from Reuters doesn't mention race and gender, the article implies these researchers focus on AI and ML.

In regards to the "specific case", I would have to guess at what that case might be. Were I to guess, it seems like I'd be guessing wrong as this assertion seems to lack grounding in fact.

Naive or not, peer review is in place and part of it's purpose is to keep the biases of researchers in place. History has proven that this is far from infallible, but it's the process we have today and the process Google agreed to when it hired these researchers.
Spotify is ubiquitous. There is hardly a device that doesn't support it.
Totally Agree. We have quite a few smaller professional communities switching to our airsend (https://www.airsend.io/) exactly for the same reason. What we hear often from these users is that managing discord (tool) takes more time than the actual communication. It is ideal for large communities but if you want something simple discord is not the way to go.
Everyone has their idea of what a "healthy, functioning society" is. To me, a society fighting this optimally would maximize QALYs. That means some really elderly people will be permitted to die while high connectivity young uns would be vaccinated.

Of course, the naïve view is that there is one known "healthy, functioning society" and that others are optimizing for greed or some other vice.
From my observations, people that don't act certain are not necessarily respectable among other people. I mean, I agree that saying "I don't know" is morally correct, but in practice, in real life, it's not the best strategy.
Several classes of opioids have been shown to cause neuronal degeneration via ATF4 activation. So, key points:

1. Loperamide is not unique. I don't know why these researchers have singled it out. Is it because they heard there's an opioid that doesn't get you high? It only avoids getting you high because it doesn't get into the brain. IF you deliver it to the brain to treat a brain tumor, it will get you high.

2. Patients with GBM already get a shit-ton of opioids for pain, which do cross the blood-brain barrier. Is there any reason at all to imagine that this opioid, using the same mechanism as other opioids, if delivered the area other opioids already reach, will have a different outcome?

3. I don't understand why identifying that loperamide causes cell death via ATF4 is even worth publishing. "Opioid that causes cell death uses same mechanism as other opioids that induce cell death"? Maybe I'm missing something here?

4. This was published in Autophagy. Which is another way of saying it wasn't novel enough to be published anywhere anyone reads. Which is why this is a university press release, and not a discussion by anyone else.
KFC has had some absurd marketing in the past few years. Another example is the anime dating sim game they released, "I Love You, Colonel Sanders!" Personally I am a fan, I love the creativity.

https://store.steampowered.com/app/1121910/I_Love_You_Colone...
> Some randos on the internet believe that you could consume a bottle of loperamide and overcome that inability to get into the brain. In theory that’s true (since the brain barrier is actively pumping it back out and there’s gotta be a limit to that rejection), but I don’t think it’s worked out in practice other than causing massive constipation.

It's a medication that gets stolen by drug users which is a bit frustrating if it's not working for them.

BNF and Department of Health (England) don't describe addiction to loperamide, but do describe its use as an adjunctive treatment for people trying to come off opioids, which suggests it's not that problematic: https://bnf.nice.org.uk/treatment-summary/substance-dependen...

https://assets.publishing.service.gov.uk/government/uploads/...

> Prescribing symptomatically can reduce some of the physical effects of withdrawal. There is no systematic evidence that any of these medicines work to improve outcome but they may be useful for the clinician in situations where it is not possible to prescribe effective opioid substitution. Particular care is needed concerning the risks of polypharmacy and ensuring appropriate supervision and support in such cases.

> •Diarrhoea – loperamide 4mg immediately followed by 2mg after each loose stool for up to five days; usual dose 6-8mg daily, maximum 16mg daily.
The lawn mower eyetracking pattern for scanning comparison tables
"Normally, autophagy regulates normal metabolic processes and breaks down and recycles the valuable parts of damaged...cell components thus ensuring the cell’s survival...In certain tumour cells, however, hyperactivation of autophagy destroys so much cell material that they are no longer capable of surviving."
In case you're looking for something similar, but django-boilerplate doesn't adjust, try cookiecutter-react-django instead. It has Heroku deployment, and a minimalistic approach.

https://github.com/ohduran/cookiecutter-react-django
Counterpoint: No.

Use the vaccine to protect the people who are actually in danger. If a billionaire gets covid they can get the super special sci-fi insta-cure that every other person in power gets.

The solution to a public health communications issue is not 'get influencers on board' it's to amplify the science communicators who are already doing it, and public policy.
Using AWS Porting Assistant to Migrate from .NET Framework to .NET Core
Fedora may use CoW for package install on BTRFS
Former Zoom Employee Wanted by the FBI for Support to Chinese Government
This article is morally wrong, but the rich is going to get it before the rest of us anyway. I say give it to them, you can't change the fact they will get it first, at least let them beta test it. After most people get it, the risks disappear.
From what the article mentions, it looks like the sensitive subjects they worry about are those which can get a company burned at the stake on social media these days. It's not great, but it's un unsurprising effect of the current culture wars.
Statement by the President on the authorisation of the BioNTech-Pfizer vaccine
As jameslk also mentioned, this article mistakenly uses "dominteractive" interchangeably with "time-to-interactive". They are not the same metric. Lighthouse uses a different algorithm for computing TTI.

https://web.dev/interactive/#what-tti-measures

https://developer.mozilla.org/en-US/docs/Web/API/Performance...
I discovered so many wonderful documentaries thanks to youtube, some about things I had never heard of before. "It’s in YouTube’s interest to keep us watching for as long as possible", and the way youtube keeps me watching as long as possible is to recommend stuff that I want to watch. I don't understand the problem with this metric. Is it that some people watch things they don't really want to see, like a trainwreck? But why do these people who compulsively watch things that they don't really want to watch keep checking youtube at all? Why don't they hit the dislike button? Wouldn't that adjust the algorithm?
IAC to spin off Vimeo – booming during pandemic – to standalone company in 2021
The author seems to be overstating the actual value of the vaccine. The fair market value is probably somewhere around $10k right now. Any more than that, and you're rich enough to just hop a private jet to New Zealand and hang out with other millionaires right now. The people who would actually pay for this are the 9%; those with just enough means to drop a serious sum, but not enough to abstract away reality the way the 1% can.
Can we call this the Oppenheimer Syndrome? I see so many opinion pieces from software engineers lamenting how they've created this "horrible thing" by working on social media recommendation algorithm X, and it all fits neatly into this painfully predictable trope of how we should all live in a camper and use a Nokia from the 90s.

Yeah, I'm jaded and of course there's merit at the bottom of all this, but I really can't be arsed to read another high and mighty essay about how one person in the course of their duty led the entirety of humanity astray by recommending what people are engaged by online.
I don't know if chronic opioid exposure drives other cells to death. It certainly does cause some neuronal death, which we've already established with other opioids, also using the ATF4 mechanism. The tumor in this paper is a brain tumor.

AKA, drug belonging to [drug class] that kills [neuronal tissue] will also kill [bad neuronal tissue] through same mechanism as [general drug class].

The key question is "if putting a shit-ton of opioids (which already cross into the brain) in cancer patients doesn't already meaningfully treat this condition, why do we imagine that delivering the same class of drug past the blood-brain barrier suddenly will?"

Having worked in a breast cancer lab once upon a time, I can tell you: because run-of-the-mill cell biology doesn't get grant funding if you don't attach "early cancer diagnostics" or "potential cancer treatment" to the grant application.
Same, my spotify thinks I'm very obsessed with Ambient and Classical. I mean I enjoy those genres, but they're not my typical "active listening", I just always want some sort of sound going on in my apartment.

Also whenever I'm DM'ing a D&D game the majority of my daily mixes change to video game music for weeks because I use them as backing music.
Everyone is blaming the Spotify algorithm for bad suggestions. I ran this test, it's my OWN TASTE that turns out to be bad according to this :(

Jokes aside, I think this is a really neat toy with a great sense of humor
In case you happen to see this late reply, I do not have a problem with moving to completely paid plans since "free" costs you money and time. But the short notice of one month during a time like this was really not thought through at all from the users' perspective. Unless you were going bankrupt, this is unconscionable. Your update and rebranding didn't say one word about the short notice and the reasoning behind it.

Also, the lowest paid tier has limitations whereas the next tier after that is a huge jump in price.

For these reasons, I cannot consider Migadu as a trustworthy provider right now.
I suspect that the Supercharger network will quickly become commoditized as charging stations appear everywhere. Every grocery store, mall, parking lot, and restaurant will put a few chargers in. This will be mostly to defend their business so that people with electric cars continue to patronize instead of going to a competitor with an electric car.

BTW: From what I understand, gas stations don't make much profit from the gas. I suspect the same kind of economics from operating a car charger.
See also the Web Almanac for an in-depth look at the state of the web: https://almanac.httparchive.org/en/2020/
My badness made me laugh. I like certain show tunes when I program. Don't judge me, the web site already did. But because I read a news story about The Chicks rebranding and got curious about their new album, it got added to my gestalt.

Thus:
Your spotify was like-country-but-smoke-weed-with-your-gay-friends-drama-club-tonys-watch-party bad.
Maps (Offline OpenStreetMap maps) - https://f-droid.org/packages/com.github.axet.maps

Source is hosted here:

https://gitlab.com/axet/omim/tree/HEAD
If you've made your own MuZero implementation, please let me know and I'll be happy to link it from my blog post :)
I have no problem, let them pay more and subsidize for the rest of the people. At least for covid, the risk is low enough to not matter. I would happily be the last line to get one.

Besides I'm not sure supply constraint would be a big problem, i think there are quite lot of people that understand the actual risk of getting seriously sick from covid and wouldn't be that eager to get a vaccine.
Digital Developer Relations: Past and Future
Forgot the reference to BerkeleyDB ;)
On my iPhone it wasn’t just a bad experience in the viewport. It also fully blocked screen rotation for 4-5 seconds and made me think my phone had frozen. I only rotated because there was multicolumn text that was hard to read in portrait. The typography is very pleasing to the eye otherwise, but I get the sense it wasn’t even tested on a phone.