skysight-inc/HackerNews huggingface dataset:
You have a dosing error that resulted in some participants getting half the dose initially, and this group turned out to have substantially better resistance (~90%) than the one receiving the full dose (~60%).

This is completely mysterious, in the opposite direction of every other vaccine candidate, and should we be following normal safeguards, there is zero chance this vaccine would be approved.

It also raises concerns of rushedness/negligence. When you get two conflicting measurements of the dosages, the correct response is to test it a third time, not assume the second is correct. This failure mechanism was the same in Boeing.

Not that we need to be: we already have Pfizer and Moderna, that did their trials properly and showed proper results.
Given most buildings are upwards of 90% air by volume, that's still quite dense.
Depends. I was able to program my parents DirecTV remotes to do the input switching so they can go between their DirecTV boxes and the Apple TVs - the only LG specific remote code that we needed. I guess the DirecTV remotes learned the volume up/down and power too. Everything else is handled by the other boxes and their respective remotes.
Or, alternately, hospital administration is doing an excellent job of optimizing for revenue by oversubscribing their biggest profit center.

SoCal hospitals have been infamous for sending any baby they can to the NICU for any reason so long as the parents have insurance, because regular L&D is a cost center. Is adult ICU really that different?
You could use something like `sh -c 'time ...'` to work around that. (You might need bash instead of sh, it might depend on what sh is on your system.)
There have been many studies that give people a few hundred IU per day (versus a few thousand) of Vit D that show little real benefit, tragically. This leads people to believe - through the pretense of knowledge - that Vit D supplements are useless. Combine that with high faith in "science" as if studies can't ever be poorly designed and blammo now you have experts telling people it's a waste of money that makes your pee expensive. It's truly sad.

Just Google "vitamins are useless" to see what's getting turned out.

Edit: personally I feel it's like giving starving people 200 cal per day of food, seeing that they die anyhow and saying "look food doesn't work to fix starvation!" yeah maybe not, but at what dose? If the dose makes the poison perhaps the dose also makes the medicine
Scheduled procedures don't generally take up ICU space.
You are very welcome.

There is additional information available here:

https://professorhewitt.blogspot.com/
We've had a year at this point to prepare. Was there any effort to ramp up additional temporary facilities? Is it ICU beds, equipment or healthcare workers where we are falling short? From what I've read, the need for ventilator seems to be non-issue due to early stage hospitalization protocol changes.
Maybe it's not publicized, but it seems stay home was the only step A, with no step B. The time that bought us seems to have been wasted.
Seasonality is huge at Amazon. And it depends on the nation too. US, Japan, and EU states all have wildly different seasonalities. Seasonality here should be construed at all levels. For example on a daily basis Japanese peak is after the work day ends, while US has a flatter curve since Americans are willing to shop online during their work day. And then there are special events like the world cup flatlining EU purchasing while US is unaffected.
Not all of them. My parents LE OLEDs power up faster than my older "dumb" Panasonic plasma.

Samsung TVs menus and response times are crap, however. Not sure how they are so wildly popular.
Less effective is perhaps a misleading word choice, remember the Phase 3 trials are measuring efficacy in preventing any cases (as defined in the study endpoint).

Despite the efficacy being lower the Oxford vaccine is extremely effective, not a single vaccinated recipient was hospitalised once 21 days had passed from the first dose.
> banned

As you very well know (because you've been corrected on this inflamatory phrasing a bunch of times on HN), it has not been "banned". It has not yet been approved, which is very different.
Most of us feel this, but an Elon Musk or Bill Gates may find this thought of an alternate life foreign, or at least horrifying.
Actuary.
Some components are Win32 primitives, and it may not be possible to modify them. You could try asking it in the forum[0]? Lead developer is quite responsive.

https://resource.dopus.com/
I personally prefer Venus.
This factoid [1] may soon need an update.

[1]: https://www.guinnessworldrecords.com/world-records/largest-r... "Largest rocket"
You can't switch radioactive decay on and off. The heat source is always on.
Or you can just pay for all that stuff to be managed. That's the whole point of the cloud. Everything you just listed is done by our cloud provider.
Specifacally, only one lake is natural. The rest of them are manmade.
We have explicit cursors and classic pagination in our public facing API. Classic paging is such a thorn in our side, but almost everyone uses it for their v1 unless they ask us for guidance first. We have guides about why pagination is bad, and discourage it in our API rate limits, but it still persists.

Looking back, I would exclude classic pagination from a public API and go full cursor. Possibly include an optional total count that can be requested (counts are expensive in PG though).
oups indeed I meant micro not macro

RTS without macro would make no sense
On some Samsung TVs I have used, and least one model of either TCL or Visio non-smart menu functions are slow and clumsy. Input switching on one "smart" TV in particular (I'm pretty sure it was a Visio) was like a four step process instead of a simple button press. It was really eye opening just how bad designers could screw up something that should literally be a one button press. You can't assume anything with new electronics - some of the UI designs are stupendously horrible.
Software engineers in the USA get paid well enough on average that you can live a modest life, save up serious capital, and then bootstrap your own company or side hustle. That will get you more status.
Same here. Big win for other social media platforms probably.
I don't like the whole Cloud sync thign
Yeah it's shit for scaling
Or just don't buy Samsung TVs. Their UI's are crap even for the "dumb" functions.
>AoE 2 (DE) has 35 (he gives it a 3), making over 600 possible 1v1 matchups.

The 3 species in Starcraft are quite distinct in many key areas, whereas in Age of Kings and AOE3 (the only ones I've played) the differences between the factions were limited to a handful of units and buildings, but ultimately they all played pretty much the same.
The strategy comes in the race to achieve points before the game ends. It turns out that buying lots of cards and building a massive engine on a whim may not be more efficient than just buying silvers/golds/provinces all the time. There are lots of subtleties in the timing of purchases, and determining ways to create a slightly more efficient machine than your opponent.

IMO it's an terrific 1-on-1 game where meaningful strategic and tactical decisions are made, but I find the game a lot more "fun" with three or four players (five players takes way too long)
LOL! It was a very toxic community
It seems that these horror stories are happening more frequently and makes me wonder if Google/YouTube is suffering from complacency rot. This happens when people stop caring and just start "doing their job" or "following protocol" which is usually easier than caring.
Nice use of "factoid". Most people use this world incorrectly.
or hate each other...
I remember someone pointing out F# build system code (aka FAKE) in a movie and realizing that someone on the movie set must have googled "fake code" and grabbed the first result. Tried to find the link but can't.
sorry I meant elective procedures
Obviously this is because California’s government is full of ignorant, backward Republicans who are ignoring the threat, denying reality and not following the science.
I'm not confident I have a full understanding of the tradeoffs / I will be doing more research once I can actually access either / availability will probably be the deciding factor anyways, but with that said:

As I understand the state of things I'd be more comfortable getting the AZ/oxford vaccine than the Pfizer/BioNTech vaccine because the underlying technology is less novel, and therefore there is less potential for unknown long term side effects (of the unknown unknowns variety).
Funny, I'd think the other way. Everything I know about these guys is they constantly want an alternate life - and they work to make it happen.

They both could have "stopped" decades ago and have achieved more than 99.999999% of people who ever lived, but instead they are pushing against something different continuously.
How about the PGP word list? https://en.wikipedia.org/wiki/PGP_word_list

$ ping stairway scavenger tracker upcoming

PING 209.216.230.240 (209.216.230.240) 56(84) bytes of data.
64 bytes from 209.216.230.240: icmp_seq=1 ttl=50 time=68.2 ms
64 bytes from 209.216.230.240: icmp_seq=2 ttl=50 time=69.5 ms
64 bytes from 209.216.230.240: icmp_seq=3 ttl=50 time=67.2 ms
Given the confusion over the reuse of the term “cursor”, I prefer the terms we (Google) have settled on for Pagination [1]: page token and page size. It’s often awkward to argue about “really, do I need to support pagination from the outset”, but the examples given in that AIP are from real-world battle scars. Even if you just set the page size to a big number, at least you prepare your callers for “one day, you’ll need to handle this”.

[1] https://google.aip.dev/158
happy to hear that this is still going on !

I lost interest in FA around the time when FAF was in its first betas.

Planetary Annihilation is more or less a successor but I could not get into it.

I like its idea but in practice the micro was insane in order to keep an eye on several different planets.
Sony takes LG OLED panels and rebrands them with their own signal processing. It REALLY makes a difference if you are into 22fps or 4-4-2 pulldown with movies. Every once in a while Costco has the Sony OLEDs at the same price with the LG's (normally the Sony's are more) - that's the time to buy! Same OLED panel, but Sony's video processing is better so if you catch them when they are price the same pick the Sony!
Simplicity and intuitiveness.

Make is super easy to do simple tasks: crop, blend, merge separate clips and insert transition and texts.
This covers 90% of needs.

If you tackle this - it's a winner.
It looks like most of them were removed for being too weak.
I'm wondering if the point of this article has been missed. To me the point was here:

> We seem to find meaning in what’s never happened. Our self-portraits use a lot of negative space.

That what we didn't do, the choices not made, are as essential to us being us as the choices we did. It's what "The Road Not Taken" is really about--as Joshua Rothman knows, but many people miss, including the guy who wrote that sticky-sweet self-help book.
You should read the article, it elaborates on this and lays the issues mostly auto the Oxford team.
I'd say its not the travel itself, because travel by itself is pretty shallow. I'd say the experience of living with other people who are especially socio-economically or racially different than you, that changes things.
I doubt that is going to happen. Apple is a premium brand, for the premium segment of the market…

I've seen the M1 Mac mini available for $625. There will come a point where the M1 is cheap enough for a broad range of consumers, especially compared to the quality of consumer PCs in that price range.

…but a massive chunk of the market cares more about price than performance

True until the price gap is small enough that it common sense says paying $100 more for a Mac is a no-brainer.

There's also the issue of no crapware preinstalled, ads everywhere and software that's free to use for 60 or 90 days, which is typical on low-cost PCs.

Apple is also playing with a 30-35% margin which gives them room to drop prices as needed.

If college campuses are open in the fall of 2021, many of those freshmen will arrive on campus with an Apple Silicon laptop…
It works just fine. The samples are tested in the UV-VIS at 280nm.
A Resonance Theory of Truth
Did you win when you did that? The strategy varies quite a lot between instances of the game, but often I find that those kinds of “engines” happen too late in the game to really be valuable, and by then someone might have bought gold and provinces.
My guess would be it will still have a launch escape system for the passenger variant. So if the belly flop doesn't look right or if it doesn't stick the landing it just ejects the crew.
They had some sweet ideas.

I just watched a retrospective on 20 years of Double Fine. Tim had some interesting comments in there about how BL came to be. They were avoiding very hard to make or market the game as an RTS because the genre already had a big stigma at the time.

It might kinda explain the weird state of the game. It was definitely a fun and interesting experience but it was also flawed .. way too many games packed into one for its own good.
I'm sure SpaceX would be interested in your plan to get to space without passing through FAA regulated airspace.
Source? Other than the radioactivity, plutonium isn’t any more poisonous than other heavy elements, afaik. And it’s not a lot of material.
The paradox of twelve steps is that you are supposed to consider yourself at powerless and submit to your higher power yet at the same time every failing is only down to you and resets all progress.
He's not doing that because the TV is connecting to wifi, he's concerned about "wifi radiation" - sigh.
Elasticsearch’s search_after is a pleasure to use. So easy especially with nullable fields, where the equivalent SQL can get really, really messy with just a few columns.
You don't need jQuery. Every problem jQuery solved has been standardized into native javascript so you can just use Javascript to build web apps.

For example instead of $(".button"), you can do document.querySelector(".button"), and so on.

That said, if you must use a framework and looking for something less complicated than react, look into Vue or Svelte.
I've only played a hundred or two games, but my answer is not really. You're in a race to get enough victory point cards before they poison your deck into impotence. An action combo uses more money and buys to get online than a handful of gold, and is more succecptible to be poisoned by green. Missing even one turn to a bad hand hurts a lot, in about half of my most recent games the winner was decided by turn order (they went first so they grabbed the last province on turn 14, when another player who only had 13 turns was ready to buy that province).
Zero-Knowledge Auth: Scheme for Private Account Logins
There is a company called Serum Institute they have been doing production for sometime now.

https://www.businesstoday.in/current/corporate/serum-institu...
Many emulators have this functionality, called netplay. For example Mesen, one of the best NES emulators available:

https://www.mesen.ca/docs/tools.html#netplay

Also RetroArch (which has cores for many systems, including Genesis):

https://www.retroarch.com/index.php?page=netplay
Has Thomas Becket's treasured 'little book' been found?
They also want to be able to refuel super heavy in orbit off another super heavy.
Corporate Entropy and the Evolutionary Arrow in Business
Moderators, please.
You can’t cycle your deck multiple times per turn, iirc the discards don’t happen until after the turn ends.

Aside from that, it’s definitely not the only or best strategy. Buying gold early can usually edge it out, and it’s very vulnerable to curses.
There's a bit of variation, even in the base game.
Element AI sold for $230M as founders saw value mostly wiped out
Higher fat content also means more satiating, so you won't feel hungry shortly after eating. If all of the ingredients are healthier than McD, that should be a clear win. OTOH I don't think burger is a good choice for a healthy meal anyway. I'd choose a hipster version primarily for taste and aesthetics.
It also acts as a pseudo-internet archive. The original images may not be easily found on the internet anymore, but Pinterest still has them scraped with broken clickthrough links. Which can be both useful and maddening.
Absolutely no :)

What I wanted to express here (and did badly) is that crossing paths with this arcane Class-A style IP address is something so strange nowadays... in my case in more than 10 years professionally working as a developer, I had seen it exactly once and even then, didn't recognize it for what it was.

The code snippet was just an extra curiosity in case anyone found it useful.
Traversy Media on Youtube. This guy is a GREAT teacher and has a LOT of free videos you can learn from: Intros to HTML, CSS, Javascript, and real world mini-projects to show you how to build things you can use yourself or in a portfolio. Mostly short videos (less than an hour) and a really easy person to learn from. He taught himself to code and really knows how to explain what might be complex topics in Web Dev and more to people who have never coded before.

https://www.youtube.com/channel/UC29ju8bIPH5as8OGnQzwJyA

Good luck!
Yeah. uBlock Origin is just hiding the results, like it hides blank spaces after it blocks ads. You might notice a momentary flash only for the first few times, or on slower machines.
The typical length of a game varies with the number of players. It sounds like their first game was with 2 players and like you typically are in larger groups?
>> A lot of people online say that travel makes you a better person.

Probably every experience you have can make you a better person, it doesn't need to be travel.

I used to travel a ton for work and fun (there was a year where I hit 6 continents in a 10-month window) but spending the last 9 months in a one-bedroom apartment with my wife and our newborn is no less mind opening.

In fact, like everything, travel gets old. At some point you know that you "got it" - you can be dropped in a random point on the earth and make something out of it - and yet you may not know how to be at one place for a long time (I am learning that now.)

Also, it makes things less special. In a way I am jealous of people who are dreaming of going to Paris and then experience it for the first time.

You do you - save your money, invest in relationships around you, learn things on line, be a good child and parent. If that's "all" you have to show against someone who has been everywhere but doesn't have what you have, you're ahead.
It is nurses and doctors that are the limiting resource. That pipe cannot be increased easily.
>We've had a year at this point to prepare. Was there any effort to ramp up additional temporary facilities? [...] Maybe it's not publicized, but it seems stay home was the only step A, with no step B. The time that bought us seems to have been wasted.

That was the plan? As in, do lockdown, prepare hospitals, then lift lockdown and let the disease sweep through the country until we reach herd immunity? That would have resulted in hundreds of thousands or even millions of deaths. I always thought the plan was: lock down, wait until vaccine, get everyone vaccinated, then lift lock down.
> IPv6, ..., is how the Internet is supposed to work

No, the way the Internet is supposed to work is that you have one routable address space. If you need to expand it, the previous address space is imported as a subset of the new one.

https://cr.yp.to/djbdns/ipv6mess.html

I will never forgive the IPv6 for not making the 32-bit IPv4 space a subrange of the 128-bit IPv6 space. Years after winning the IPng wars they admitted their mistake and standardized NAT64, but it was too late. NAT64 should have been part of IPv6 from day one, and every IPv6 router acting as a default route gateway should have been mandatorily-required to offer NAT64.
I am surprised that systemd portable services is so little known. It solves many of the same problems as Docker does but is comparatively simpler. It also requires more plumbing on top but I prefer it.
Given the nature of space, what we probably need is an international space agency to handle regulation.

Might be hard getting USA, China, Russia and the EU on the same page though.
A Convolutional Neural Network Smartphone App for Real-Time VAD
considering this is over 50 years after Saturn V, I don't feel this is such a huge feat.
Yes, except as beginners, you probably bought a lot more cards for your engine than you actually needed: at some point you’ll need to decide to start greening rather than buying actions. While blowout games are easy at first, optimization and learning the balance of money vs actions will start trimming turns off your games.

Another factor is that with experience, your opponent will either recognize what you’re doing and defend by buying the cards you’re wanting, or get their own engine going to beat you if they learn from their mistakes.

Most games are won by buying out the provinces, yes, but the three stacks win is there for a reason and is great for catching opponents off guard when the kingdom’s right.
A “modern looking” web site doesn’t really need any JavaScript framework or library. What are you looking for that vanilla JavaScript cannot provide?

There are, of course, alternatives to React. Angular, Svelte, and Vue are among the most popular. There are even light weight versions such as Alpine. But it’s hard to make any recommendations without understanding your requirements.
A launch escape system is not necessarily safer than without one.
I am not sure why, but the quote triggered a memory of 8bit theater in my head:

"Life is funny. You start out with limitless potential, but time is always shaving away the possibilities. Every choice you make is the choice not to do a thousand other things. What's important, when all is said and done, is that you made a difference. Your choices, and everything undone, have to mean something. Otherwise, what is the point?"

We branch out, but we ultimately keep heading towards the very same outcome.
Honestly, RTS games are already so bogged down in complexity that I wouldn't want to see one adding logistics unless it decided to claw back other gameplay features.
That is actually correct.
The Ethical Challenges of Connecting Our Brains to Computers
They could launch from outside America.

They've already said they plan to launch from floating platforms in the ocean...
I implemented this for Datasette. The key is to use the primary key as a "tie breaker" - so you sort by the specified column first and then by the primary key.

I managed to get this working with compound primary keys too: click "next" at the bottom of this page for a demo: https://latest.datasette.io/fixtures/compound_three_primary_...

The code is pretty complicated - mostly here: https://github.com/simonw/datasette/blob/0.53/datasette/view...
Pinterest is honestly a relatively fine platform with interesting and well thought out apps (can't say that about some of the major players). It just hurts that they keep spamming search results. You'd think at this point it would do more to hurt their brand than help it.

If they had the simplest tool to help tracking down an image's source at least they would provide any value.
UV visible does have all those benefits you mention. What went wrong here is what is called “validation” and is a big part of pharmaceutical analytical analysis.

You not only describe how you measured your drug concentration, but you also test the limits. And those limits should go beyond anything you might encounter in actual manufacturing.

If your aim is to confirm a concentration of 5mg/mL, then you test all the way down to 0mg/mL and then 50mg and 500mg/mL. Then if you have a saline mixture, you test different concentrations of NaCl.

You’re basically trying to break the analysis to show where it doesn’t work.

The fact they did a UV vis and didn’t account for a different emulsifier is a big miss.