skysight-inc/HackerNews huggingface dataset:
> the emphasis in the wiki article is on DNA, the same basic principles apply with RNA.

This is not my understanding. PCR works to produce DNA because the DNA polymerase enzyme creates DNA copies from DNA templates, and those copies become templates themselves, feeding back into the chain reaction.

I'm not aware of similar enzymes capable of making RNA copies from RNA templates (RNA polymerases use DNA templates AFAIK).

I was imagining the RNA vaccines would have used a fully synthetic oligo production method, to get the extreme purity required. But it might be that some sort of PCR-like amplification process is used. Would love to read more if someone has details.
Knock yourself out: https://www.azul.com/downloads/zulu-community/?package=jdk

(I assume you can sub in your own JDK with Minecraft? Never used it)
Build an insurance pricing model and compete in a market, prizes worth $12000
Yeah, sorta wrong. Sure, computers are already really fast, but the big thing with the M1 Macs for me is that they've finally came out with a laptop that doesn't heat up like crazy when I'm using it for moderately demanding tasks.

Also every laptop I've had prior, would get pretty hot or the fan would get quite loud when connected to an external display. This M1 is completely silent when doing that AND it doesn't throttle.
This is absolutely not a dumb myth.

It's obviously true that open source is not sufficient to good software quality, or even necessary, but it does correlate, especially for open source projects with many users.

I often read through the libraries I use in projects (if their source is available). And if I find errors or shortcomings I will write an issue about it.
Yes, everything has limits. Where Google says "quota system", for normal people that means "buy another computer"; you have hit your quota when you're out of memory / cpu cycles / disk. At Google, they have some extra computers sitting around, but it's still not infinite. Quota is a way of hitting some sort of limit before every atom in the Universe becomes a computer on which to run your program.

I don't think there is any way to avoid it. It sounds bad when it's software that's telling your service it can't write to disk, rather than the disk not having any more free sectors on which to write, but it's exactly the same thing. Everyone has a quota, and left unchecked, your software will run into it.

(In the case of this postmortem, there was a bug in the software, which makes it all feel self-inflicted. But if it wasn't self-inflicted, the same problem would have manifested in some other way.)

There is a comment in this thread where the author says they take less risks when the safety systems are turned off. That is fine and nice, but is not really a good argument against safety systems. I have definitely had outages where something hit a quota I set, but I've had more confusing outages from something exhausting all physical resources, and an unrelated system failing because it happened to be nearby. I think you should wear a helmet AND ride safely.
> I'm unease with the fact that I don't really know that my Swift program is doing in the background, and more so, the fact that the vendor (Oracle, Google, Apple etc) tries so hard to prevent me from finding out.

Eh? Apple's fairly clear about what Swift is doing in the background (which isn't much, really; boring ol' reference counting).

This might apply more to Java, mind you. There are no secrets, but most people probably aren't going to investigate exactly what the JIT or GC are doing.
>Inflate the administration body, filling the University with a majority of career bureaucrats who contribute nothing to research, teaching or learning. Then inflate tuitions to unaffordable levels so you can pay for the bureaucrats. Next, drop merit requirements for (-both-) students

All of this is correct.

If you're refuting this, you either don't pay attention to anything, are some old fudder who went to uni 35+ years ago, or are living in a gigantically blown bubble.
FDA grants authorization to Moderna for 2nd Covid-19 vaccine
It’s a clever joke because exterior algebra (https://en.m.wikipedia.org/wiki/Exterior_algebra) is also knows as Grassman algebra, named after Hermann Grassmann (https://en.m.wikipedia.org/wiki/Hermann_Grassmann)
Create a CLI in Golang and publish on NPM
IMHO system libraries and OS architecture are more important for portability than the processor. In that sense x86 Windows and x86 Macs are already about as unportable as you can get.
Yes and no. First of all, you don't get tenure right away, so your first few years are brutal -- 80 hour weeks. You typically get "start up" funding, which eventually runs out. Then you have to come up with your own money. The basic salary is 9 months. Your summer salary comes out of your own grants. Also, if you stop making research progress, your promotions and pay raises evaporate, and it becomes difficult to promote yourself by job hopping.

Think of it like you're a shopkeeper at the mall, and someone is paying your rent for you, which is nice, but you have to figure out how to actually make money.
Your last statement might be the most short sighted statement I’ve read this month. In fact I don’t even think it’s short sighted, they are already incredibly practical weapons.
Game journalism is 100 % click bait. Nothing new about it at all. EA and Bethesda have gotten away with way worse. If you don't believe me go find a big publisher game that got a ZERO rating like games did back in the day if it didn't run/crashed at launch for example. Today the same game will be served on a specially made PC setup by the publishers tech-team before you entered the room and you test the game in their paid suite while eating free snacks. Then it gets a 7. Not because of the crashes but because the snacks were old or you didn't win in the random number generator lottery and got mad.
But absent the original properties, there's no commercial value to this thing, so without Seuss and Roddenberry this book wouldn't exist anyway.

Exactly. The value is in the original properties. As an original work with new characters, it would flop.
I hear what you are saying, but there is a big leap between TN and "JSON/YAML/XML/s-exprs". One is isomorphic to 2 and 3 dimensional structures, and the rest are not, connecting the software world to the physical world. This will turn out to be very important and groundbreaking.
It's unfortunate you didn't have luck with medication. One thing to consider is asking your psychiatrist whether there are pharmaceutical trials you can join, one of those might be helpful.
Spontaneously, yes - fairly amazing. But what if the person treated with the mRNA vaccine happens to be infected with another RNA virus that is producing reverse transcriptase enzymes to convert its own RNA into DNA?
There is one thing that my friend's father said to me once, about these analogies between universities and businesses. A typical business lasts in the order of 20-30 years, a couple of generations if lucky. Most famous universities have lasted centuries. And these is the western university system, starting with Bologna, Paris and Oxford after 1000 AD. If you expand the definition of a university slightly broader, you find the famous universities of Sankore, Baghdad, around 800 AD (the syllabus included Aristotle and Euclid), and even before that, Nalanda and Taxila from around 300 BC-1000 AD, and Alexandria from the Egyptian times.

A university is a slow moving, lumbering beast. But analyses like these are too shallow to understand why it has lasted so long, and why every place that was once a centre of human civilisation also had a great university.
Is it DRY if you use rsync instead of copy&paste?
> If you're refuting this, you either don't pay attention to anything, are some old fudder who went to uni 35+ years ago, or are living in a gigantically blown bubble.

I haven't paid attention to the latest fads, but when I went to Uni 35+ years ago, "gigantically blown" bubbles were regarded to be superior to small bubbles, as far as intellectual universes are concerned.
> you don't get tenure right away

I don't understand how you can be a professor and not be tenured, so I guess we're talking about different things.
But where in a large forest is your enemy? These things can search and destroy, especially if they get quieter. Imagine letting these things lose in a cave system. Explore, seek and destroy with no human intervention.
“ The qubits were teleported over a fiber-optic network...”

I don’t think you know what that word means.
Apple has a much more ‘my way or the highway’ approach to its developer community than Microsoft.
Aren’t a lot of these grad students internationals? It’s immigration laws and culture that drive them into grad school, not the privilege of teaching undergrads.

Loads and loads of parents of international students push their kids into grad school because they want them to climb the ladder to the upper echelon. They don’t know how to accomplish this in the corporate world because that ladder is more like a maze of culture fit dead ends. Then it’s the immigration laws which make this path extremely risky (getting fired and losing your visa, then having to go home).

So the focus is on school, which they already know how to do well at. As long as you stay in academia, you can safely maintain a student visa. It’s your foot in the door. And then when you graduate with an advanced degree you’re much better positioned to get a long term visa leading to a green card.
To play the devil's advocate: We really, truly, desperately need academics. The human race would be very much worse off if there weren't a significant number of people spending their lives on purely intellectual pursuits in the name of curiosity instead of quarterly profits.

The problem is not the role of academics in the world, that's clearly very important.

The problem is the current economic situation of Universities and their relationship to post-docs. It's more akin to a pyramid scheme or a ponzi scheme than a valid career. The music hasn't quite stopped, but it's already fading, and the people that are paying attention are starting to cry foul.

I luckily escaped this death march, but I still keep up with Physics research, and I've noticed that the political structure of modern academia has caused fundamental research to stagnate. Risk is no longer rewarded. The tall poppy is the first to be cut. Small, incremental improvements are rewarded, big theoretical leaps are never approved for funding.

High energy particle physics in particular has completely stalled since the 1970s! Similarly, we still don't quite understand how high-temperature superconductors work. Fusion research has burnt a lot more money than helium. The efforts to marry GR and QM have produced a lot of papers, but no results.

Take a casual stroll through ArXiV, and you'll discover that 99% of the stuff that is published is a total waste of time. It's "diploma mill", "publish or perish" garbage. This means that sifting through the endless torrent of worthless papers for the occasional insightful one would be a full time job all by itself. This alone is sufficient to stall progress!

Scientists are no longer standing on each others' shoulders, they are now trampling each other in a mad scramble for funding and tenure.
What's your gaming rig, specifically your video card?
The paint could have contained lead or other heavy metals. Clearly, not mediocre but below average.

P.S. - Showed your post to some of my German colleagues. They laughed. They never laugh.
> Nobody writes slow programs on purpose,

Well problem is developers are not writing fast programs on purpose. That they did not write slow on purpose but it nevertheless turned out to be slow is real problem to me as a user.
It seems like it would be much easier to check for shenanigans in a browser based walled generator than on a mobile app. In the browser I can just got F12 to determine what's up.
95% of the America is wealthy for and compared to me, also compared to the most of the world. Doesn't mean I can't be compassionate about your working class problems etc.

All the problems in my life, for you are a phone call away too.
Not quite what you're looking for, but I've noticed IntelliJ resident memory staying suspiciously low. I have the vague suspicion that they're taking advantage of the faster processor to be way, way more aggressive with memory compression, but I can't easily prove it :)
Nip in the "bud" not "butt" as long as we're offing exacting critiques ;)

https://idioms.thefreedictionary.com/nip+in+the+bud
I’m a huge fan of C# and how Microsoft has been improving .NET recently but as a C# fan I think you’re being a little unfair to Java. It has a slightly different perspective on language evolution than C#, in that they try to keep the language core smaller. I was overwhelmed by syntax when I first started programming C#, from all the different kinds of parameters (optional, named, ref, out, in) to all the different kinds of properties, to the actual difference between properties and fields. To this day I think it’s silly that certain tools and style guides will suggest you replace public fields with public auto-properties, when there is no difference in encapsulation in practice. In this sense C# is closer to the culture of C++, where the bar for adding features is quite low.

Java just moves a lot slower, and has a different philosophy for adding features, and the core team seems averse to introducing new forms. An example I ran into the other day is applying first-class functions in Java: in C#, this looks like

lambda(arg1, arg2)

while in Java it’s

lambda.apply(arg1, arg2)

This is definitely more verbose and arguably uglier, but it hews closer to the object-oriented style because it’s visibly falling a method on an object. Of course this is happening in C# as well, but it’s hidden by syntactic sugar.
Self targeting guns, lasers, maybe even high pressure water cannons.
Even worse are undocumented quotas. Probably not quite the same thing, but I've had such an issue with a SaaS API for extracting data for a cloud system. It has an unpublished limit on queries. Writing a library of code to use it, I was fine. All tests passed. Running a full day's data pull & integration had sporadic failure: It would run w/o issue for half the job, then have seeming random errors on some requests.

I kill the job, start again, and the problem is there from the very beginning. Kill again, review my code for an hour or two (python, grequest) tweak some parameters, start the job again and it seems fine, problem solved? Nope, halfway through the same issue occurs.

More testing showed even that "halfway through" wasn't consistent.

It's the hidden quota, and it wasn't even consistent: Sometimes it would go 10%, sometimes 70%. I don't know if they even had static limits or some type of dynamic system. Then you get throttled, only requests fail without any indicative error message except the "failed" or "unavailable" (I forget which)

I determined the limit was tied to the API key. Given that error messages & the unknown limit made working within their hidden limits difficult, and support was neither sympathetic or forthcoming with details necessary to work within their limits, I simply created multiple API keys & rotated between them on requests. Probably not the best behavior for a tenant of a shared system, but I didn't see much choice when the alternative was to not use an essential advertised feature.
Few if any MBA-sized laptops are much use for gaming; if you want any sort of battery life at all you're largely stuck with Intel's uninspiring integrated options.
There is a difference between deciding "we don't need to be fast" and deciding "we need to be slow."
not only that but internal projects that one can glean information from just by knowing or seeing their existence and how they are constructed. or for yet unreleased things.. I'm surprised the few comments in this thread don't consider these sorts of things
Would you perhaps be able to answer a question I've been wondering about?

Is this way of injecting mRNA really any different from just injecting someone with a virus? Not in the sense that it makes you ill but in the sense that a virus would do the same thing just with more harmful mRNA.
Running Better Performance Experiments
> I don't know what you mean by my "chair".

Becoming a professor is called getting your 'chair' isn't it? I don't know any professors who don't also have tenure - that seems a contradiction in terms to me.

But if you don't know what I mean we're probably talking about different things and possibly talking at cross-purposes.
Literal holocaust going on there right now, how would you react to Nazi germany?
A console with upgradable CPU/GPU.
As someone who deals with 15 million lines of code (and many readers of this have bigger systems) i need to trust that do X does X without me having to know how. When I have to learn it slows me down from the part of the code I need to know well. If do J is needed, that needs to be someone else's problem who knows the rest of do X. Unless do X is my responsibility of course. But nobody has responsibility for more than a small fraction of the code.
but what does that have to do with me not wanting hackers to know what type of projects power my company, or unreleased things we're building? a whole slew of things that i would not want people seeing...thats why the repo is _private_
"Apparently big companies also can't vet or properly compartmentalize third-party software either."

Amazon, G and MS generally do.

I believe that whatever data you have, it's more secure on AWS than anywhere but your hard drive not connected to the internet.
When BERT plays the lottery all tickets are winning
Furthermore, it's gotten much worse in the last year. Now the government forces gym closures and discourages people from going outside or to the grocery store, practically forcing people to live a sedentary lifestyle and encouraging fast-food eating _even more_.
Agree, there is a lot to unpack around universities. I definitely don’t think they are beyond criticism. That being said they are one of the only non-conditional long term organizations one can be associated with as an adult(alumni).
Do check out https://github.com/microsoft/playwright - Node.js library to automate Chromium, Firefox and WebKit with a single API
This is old physical hardware, and the CPU itself has been around in some form for a while (I don't think they've done a big micro architectural change since the A12 or so), so it's probably not as risky as usual.
A lot less for sure. I've met many top 10 university graduates who are 30+ and have nothing to show for it with little respect in their domains and mediocre job prospects. It certainly is a massive help in the early 20s though.
Offline BTC wallet generator based on common Unix tools fits in 2 tweets
>You doing your thing and me doing mine.

I'm ok with that. you want to wear your mask its up to you, as long as you are not forcing it to other people.
> I think it would be a much happier world if we could trade transformative jokes and memes on the internet with impunity, but still agree that there's a bright line between that and trying to trade on someone else's idea.

Isn't that the status quo? If you make a "Oh, the places you'll boldly go!" joke on HN, the Geisel estate won't come after you - or if they do, your post will be taken down after almost everyone who was going to read it has read it.

If a million people make a million "Oh, the places you'll boldly go!" jokes on social media, maybe they'll come after the 10 most popular. If so, the world can live with the other 990,000. More likely though, they'll come after the 10 guys , the 10 guys selling T-shirts with the meme, who you already agree are fair game.
Yes, but I cannot buy just the CPU and other parts not from Apple.
Dorian Lynskey's Orwell biography The Ministry of Truth spends a chunk of its time on interactions between Huxley, Wells and Orwell. I found much of that fascinating, picturing these esteemed authors critiquing each others works(sometimes over supper).

Full recommendation for the book, even if only for the Zamyatin chapter collapsing everyone from Rand to George Lucas in to twenty pages or so.
Perhaps. It might be a matter of terminology, and each country may have its own system. In the US, a faculty member on the tenure track has the job title of "professor," but "with tenure" is an additional distinction that they hope to earn. This web page explains it as well as any:

https://www.bu.edu/handbook/appointments-and-promotions/clas...
They had a 2015 12" MacBook (the one with no fan). This was essentially an Atom; they very much sacrificed speed for slowness. A contemporary Air would have been much faster.
Thank you to everyone who has commented and taken the time to check out Sqwok. It's been a labor of love, and sometimes frustration, and it's really encouraging to see people using it and giving great feedback. It has a long way to go but I'm hopeful to realize the vision of a new alternative for open discussion.

I also wanted to share the first post I made on Sqwok, dedicated to my late friend Thom Simmons. The reason I want to share this is because you never know who you'll meet and what impact they'll have. I met Thom when I was learning python and hanging out in #django on freenode a decade ago. We went on to become good friends and he helped me learn how to program beyond html, while we constantly plotted what our next project would be. He introduced me to Reddit around ~2009 which at the time wasn't nearly as popular or known outside of tech. I had just thought of the idea for Sqwok about two weeks before his passing, but opted not to mention it on one of our last calls because he was going through some personal struggles.

I know he would have been excited for it.

In this crazy year of 2020, I hope more people can find positive connections, however that may be, and that we learn from each other, grow, prosper, and thrive.

https://sqwok.im/p/TsuqjEqi3OwXiA

I'm very grateful, thank you.
They do that as well - see "provisioned throughput"

See the section "Specifying Throughput with Provisioned Mode" here: https://docs.aws.amazon.com/efs/latest/ug/performance.html
> Why don't you quit

I did after several years. I, luckily, was in CS and landed on my feet. My partner and many friends did not quit. They, unluckily, were not in CS. So I have the displeasure of seeing it from both ends of the degree and many angles.

> Is it just sunk-cost fallacy?

Some but not all. You have to realize that the entire world is gaslighting kids every day into thinking that the hole-in-one once-in-a-lifetime shot is normal and common. But it isn't. It isn't normal. What's normal is failing to make it after giving 7 years of your life for less than minimum wage because there are 1000 applicants for every hyper-specialized position and almost all of them have more experience than freshly-defended-and-posted you, even if you're coming out of Harvard or Yale. But most people at the bottom never see this until it's too late, because nobody at the top talks about this ever. Worse, people at the top constantly lie about it or dismiss how bad everything is because _they_ made it and don't see what's so bad from where they are. They're all stuck in pre-2009 mindsets before available job postings completely fell off a cliff and never recovered.

To pervert a common expression, psychological warfare is a hell of a drug.

> which means you all need to unionize

This does happen, but, I don't know where you live, culture in the US is extremely hostile to unionization. Hell, the NLRB only decided that graduate students qualified as employees and were thus _allowed_ to unionize in 2016 after more than a decade of saying otherwise.
Why I Have Not Purchased CyberPunk 2077 Yet; Censorship in Japan
I have learned to stop trusting people who say their old computer is “super fast”. No, your computer from 2013 isn’t super fast. You’ve gotten used to the slowness.