skysight-inc/HackerNews huggingface dataset:
They are misfolded body's normal proteins, with a nasty side effect that they cause the normally folded copies of the same protein to also misfold in the same way. The result is a chain reaction of sorts.
On top of the limited, static lists, you cannot both use content blockers and sync your bookmarks and history with MS Windows or GNU/Linux at the same time. That's pretty broken.

It's really easy to do this on Android—Firefox with uBlock Origin is brilliant.
Yeah seems like vaccine development only started after the high profit objectives suffered failure. That doesn't mean we can't go back to working on those objectives in the future but they needed SOMETHING that would work to show mrna promise. Vaccines you only have to take once or twice so the side effects of immune response aren't too bad and you have an immune response to a vaccine anyways.
I haven't read a ton of Tolstoy but that looks super interesting, thanks
Another response already mentioned one aspect of how this can be used for secure communication, for detecting signal interception. But there’s a second aspect as well. Since the signaling is broken up into two parts (send the entangled state, send the measurement result), both parts have to be intercepted to decode the communication. The entangled state can be sent over a secure channel in advance, and the measurement sent over an insecure channel at the time of information transmission. This is analogous to sharing a one-time pad in advance, but the key distinction is that the no-cloning theorem guarantees that it’s impossible for someone to have stolen a copy of your one-time pad. They can only have stolen your one time pad, in which case you would notice.
Languages (and technologies in general) evolve. And as they do, it's helpful to evolve your perspective towards them alongside it.

Mobile phones started off as simply ways to call people. Are they not much more than that now? Would approaching them with only their original perspective be as helpful today?

No. The perspective has completely changed. Now, the more accurate one would be to approach them as full-blown computers.

> HTML is a single-root hierarchy whose only primary job is to display text and maybe some images. That's it and it pretty much sucks even at this job.

While HTML and CSS started in the ways that you've described. That's not what they are for now.

> Saying that CSS and HTML are meant to be used together to construct and architect pages is some serious re-writing of history and evolution of CSS and some impressive mental gymnastics.

I'm not rewriting history. I'm re-framing the CURRENT perspective of these technologies, in a way that is much more helpful. What use does framing HTML and CSS from the perspective of their origins have?

How does this help you create with it today?

With modern considerations that are more in the realm of architectural thinking than they were before?
Isn't HIV a special case though?

The reason we don't have an HIV vaccine is because HIV embedds itself in the DNA of some cells and some of those cells don't start producing virions right away, the immune system can't detect them, you clear the visible infection, but just weeks after, those hidden cells start producing the virus and the infection starts over.
So the issue with HIV is the hidden reservoir of infected cells, afik.
I will go further on VC funded companies. The Culture of Success is simple: If you are a founder, you have to be Perfect Fit, you have to design your idea around what VC's want to hear and this is working model.
One of the reasons that I never work with or for startups. Founders are rarely competent to select the right people, in most cases they lack experience in HR or Product Design, etc.
Bootstrapping is a detector for true products, you scale on a merit of real customer base not on some Valuable Idea for VC investment.
Ganja.js: Geometric Algebra Generator for JavaScript, C++, C#, Rust, Python
I’ve only been watching this from a far but from what I can gather people were fairly okay with the Game being delayed over quality issues. The fact it still shipped so broken that they have taken this unprecedented step is amazing- I guess once again it goes to show, once a software project has issues you’re probably a long way from sorting them. Could’ve been a killer q4 2021 release I guess...
You frame it as a preference that the average person has agency over - we Americans have chosen the ability maybe one day own property over medical and financial security because that's what we value!

We have massive physical land space, resources, and control our own currency. We spend over $800 billion a year on our military alone. We can demand more, but we have been trained not to.

Water, power, highways - all built when the government had the appetite for massive civic projects, and the top income tax rate was >70%. Now in varying states of disrepair, and cost more than ever to maintain as everything is contracted out to private entities.

There is no chance we would get the interstate highway system or the Tennessee Valley Authority if we needed to build it today. But we would not ask for it today, we would just supply endless excuses why it would be too much to ask.
The hosting is expensive, but it's free to self-host.

I'm running my own Ghost instance on an AWS Lightsail host. Ghost is available as a pre-built template for Lightsail and it costs $5/mo for a Lightsail instance.
Imagine if a bank had a billion dollars of BTC that got stolen while prices were rising, and they had to rebuy on market to cover their liabilities. If that happened, and the public became aware, prices would shoot up as everyone tries to frontrun the bank. Wouldn't be surprising if the bank had to spend 2x+ to cover.
For obvious reasons I have zero intention of trying to prove you wrong.
Gnome Shell UX plans for GNOME 40
VSinder - A dating app for programmers where you swipe on code
> There is no -ii ending in latin. At all.

Should you mean no -ii ending to "virus" at all, it would appear to be a reasonable assertion. However if by "at all", you mean of any word in Latin, that is demonstrably false.

http://latindictionary.wikidot.com/noun:filius

Nominative and vocative plural: filii

Usage example:

"... et nihilo minus amicum gravem virum aut fidelem libertum lateri filii sui adiungere, ..."

https://thelatinlibrary.com/quintilian/quintilian.institutio...
It's really shitty that the companies that might be actually decent places to work at are diminished as "lifestyle business" by the people who work at the places that are terrible. It really sounds like Stockholm syndrome.
Sensitive enough to detect a change in the relative length of two 4km-long arms equivalent to less than 1/10,000th the width of a proton.

And we distinguish signals from noise via a few different approaches, but our flagship search relies on matched filtering against simulated waveforms, and requiring the same signal to be coincident in time across multiple, geographically-distant detectors for which very few noise sources are correlated.
I loved the original Deus Ex and think Cyberpunk does a good job of carrying the torch. While it is clear both games have different priorities in terms of writing and activities but they both have a similar heart. I think Cyberpunk puts a lot more points into atmosphere and worldbuilding than DX ever did, personally.

And nonlethal options are presented to you as part of the tutorial. I agree that lethal/nonlethal doesn't seem to make much of a difference, but if you do stealth and melee combat from the start you have a path for nonlethal that will get you all the way through the first major mission. From there it's relatively easy to acquire PAX mods that turn any gun nonlethal.
> Sadly, in 1988 the University of Alberta CS program was stuck in a 1970s data processing curriculum and, for undergrads, had neither PCs or Unix

I feel the landscape today is very different for CS degrees. Most universities standardized quite a bit around what CMU, Stanford and Berkley are doing. But you are not the first telling me that CS degrees were a crapshoot in the 80's. EE as a pathway to software was much more common.
Even more impressive! I immediately assumed D3 but wasn't entirely sure. Congrats again on this work corroborating Vonnegut's 'shapes' of stories.
PS4 and Xbox One are several years old. When you account for the yearly or faster hardware refresh cycles for PCs and other devices like iPads, PS4 and Xbox One are both ancient and at the end of their hardware life cycle. This is exacerbated by Cyberpunk devs being primarily PC developers. ie. It's hard developing a complex open world game. It's harder doing it on old gen consoles.

I'm not saying that it's impossible, but to date, I can only think of Rockstar as the only ones who have done this successfully from the start
I'm thorouly enjoying the game but CP2077 really feels like an MVP rather than a full game mechanically.

The story is great, the side missions are great, the map is great, the art direction is spot on but the world feels empty, the looter shooter/crafting aspect feels half implemented, the whole clothing system is a mess and you can see where they have cut content (non story braindances being purchaseable but unusable for example).

Now I know Rockstar has decades of experience making open world games but these videos really drive home how lacking CP2077 is in the little things that really make a world feel alive:

https://youtu.be/PsBrkLq31eM

https://youtu.be/1IPRjzrHvak
I've been watching Skydio for a while. They're doing amazing work. I tried to build a very simple autonomous drone in my last semester of school using a DJI Mavic Pro. Was pretty difficult, though that probably had something to do with the DJI SDK not really being setup to do what we wanted. Still, really makes me appreciate the quality of work that Skydio is doing.
Why? What is their government so afraid of to inspect all country's traffic?
I find this interesting b/c:

- It raises complex ethical questions, both about monetizing children in the media, and about advertainment targeted at children who are too young to understand they're being sold to.

- It maybe demonstrates the filter-bubble in a stark way. I watch stuff on youtube a lot, but I've never heard of this kid (or really almost anyone on the top 10 list at the bottom of the article).

- It's crazy that a child can make this much money.
Apple should open up its app store to GeckoView, then. It would be great to have both WebKit and GeckoView as options.
BioNTech and Moderna both have links to Katalin Kariko so while they didn't explicitly work together on this the knowledge comes from similar research and sources.
I went ahead and returned my PS4 copy for this exact reason. Also tried on Steam (linux), but couldn't get it started beyond the intro screen and I don't care to debug further.

I only dive into a couple games a year (RDR2 last year), so I'm not going to waste my time until it's stable. I just want to buy the game, take a few days off of work, and immerse myself. If I want to debug things or deal with glitches, I can just go back to work.
Feel free to correct if I'm misinterpreting: https://en.wikipedia.org/wiki/Use_of_fetal_tissue_in_vaccine...
> 2. How does the patient's immune system know to treat this protein as unwanted if it's being produced by the body's own cells

The immune system can't know who produced a certain molecule.
I've played ~20 hours on PC, and what I dislike most is the long, downright tiring dialog sequences. It's like, half of the game is just sitting there, watching a movie, where you press "1" or "2" to decide what V says.
I saw Stacy Keach as Lear in DC.
Glouster is sitting there, blinded, gripped by despair, and Lear, mad as a hatter, is patting him on the back, saying:

"Get thee glass eyes,

And like a scurvy politician seem

To see the things thou dost not.[1]"

Totally made the play.

[1] https://www.sparknotes.com/nofear/shakespeare/lear/page_244/
I think that what happened here was almost the opposite of gamification.

Gamification is adding of artificial goals and artificial rewards, with the idea that achieving them will be addictive enough that you will continue playing. Like if you do math on Khan Academy, and then you have the animations of "you have completed the challenge" and "you have gained another level", and if you are intrinsically motivated and you came there to do the math, this is actually distracting. External motivation helps those who have none, but hinders those who already have internal motivation.

In some sense, dividing the university into grades, and organizing lessons in schedule is... a very primitive form of gamification. If you have a motivated person, you don't need to do this; just give them the books, and they will read. You don't need to set up a schedule for them, because the motivated person's natural schedule is "as soon as possible". The schedule is just slowing them down. (But it works the opposite for an unmotivated person, who without schedule would never get anything done.)

The deal is: pass these X exams, and you will receive a diploma, which is a certificate that you passed the exams. When you remove the distractions, it can be done pretty fast.

Gamification could be great for students with low motivation. But it would take a lot of time, because it means doing things that are not essential.
> I had an Atom tablet [...] and it really wasn't a great device - ran hot and very short battery life.

In all honesty the implementation and OS also matter. Most Atom tablets weren't particularly great (or even good) devices overall. And running Windows on a contemporary ARM SoC wouldn't have resulted in a better experience.
I think this is the best option (parents).

You could probably get a lawyer to set up a trust, then have the trust incorporate. Or maybe find a state that doesn't have an age restriction. I think Wyoming allows for anonymous LLCs, so that might mean that they wouldn't check your age.
I've edited it now. I think the submitted title ("Serious Adverse Effects and Deaths in the Moderna Vaccine Data") was likely a good-faith attempt to get within HN's 80-char limit.
Incentives matter, and not all "tracking" is created equal.

You are right that paying for a service doesn't guarantee you won't be tracked. What is important is that that business model makes it possible for you to not be tracked. This is critically important, because it is extremely improbable to win a fight against tracking when billions of dollars are stacked against you.
https://xkcd.com/619/
Ask HN: How to be a better data scientist?
I am a mathematics graduate, working as a data scientist at a medical imaging company. I have reasonably good understanding of the deep learning constructs that I use everyday in a research oriented environment. I'm moving to the US next year for a second masters in information management, and hoping to be hired in a FAANG like company. What can I do to prepare myself?
As a technology competent person, I agree that there has to be a better solution for self-hosted blog to really put it in the hands of the average person. It feels like we are 90% of the way there, but there could be a "single-click" install of some site generator and web server.
Top in-demand programming languages in 2021
CP2077 is a GTA clone, too. It's in the uncanny valley, though: cops don't chase you, they just spawn behind you. Even in closed rooms! It's not part of the sci-fi lore as if this was a Minority Report or something, it's just a very naive implementation.

The parts of the game that resemble Deus Ex are arguably better, but I could poke hole in that, too.
It's not more relevant, because disposable income ignores things Norwegians get 'free' (because it is already deducted).

Part of that 'deduction' pays for heavy tax-breaks and subsidies for electric cars in Norway.

But then GDP is also an abhorrent metric to use for basically anything.

If you use either GDP or 'disposable income' as a proxy metric to compare anything between countries, you should seriously re-evaluate what you're doing.
Whoever can afford it most. People who are most at risk or who have the most to lose will value it more highly, and thus be willing to pay more. Most people do not have a high risk, so they should wait until the price goes down due to increasing supply.
This is why the level of "justice" you receive is directly proportional to your ability to pay a team of lawyers in many cases.
I think the author has this really well put. They describe how they find confidence to execute their ideas in a sustainable way that works for them. This isn’t a manifesto or a telling of “the one true way” it’s just a humble succinct writing about what focus means to them. I love it.
That’s ok. We can still find patterns in them, right? What is it to stop us from looking?
I just know that i don't like proprietary software and crazy licenses.
Regarding the "formal semantics", you are correct that different implementations of Statecharts have had different formal semantics, however some effort has been put toward standardization, the main one probably being the W3C SCXML standard, which specifies a pseudocode algorithm for execution of Statecharts:

https://www.w3.org/TR/scxml/#AlgorithmforSCXMLInterpretation

It also provides a test suite that implementations can use to check compliance:

https://www.w3.org/Voice/2013/scxml-irp/

There are a number of conforming implementations in various programming languages.
I think key is that both generals have already agreed on a predetermined "meaning" of each coin flip outcome, rather than having to communicate it on a different, slower medium after the coin has been flipped.

So really it just front-loads that portion (I.e. removes it from consideration as part of the proposed solution) instead of allowing it to slow down solving the overall problem. It requires precomputation/agreement beforehand, rather than during the time allotted to the problem.

The speed of that precomputation would still be unchanged, and still be the slowest portion.
I think another factor might be the fact that the lockdowns are almost over for good, which will result in declining sales of video games in general.
I acknowledge that it existed : severe cases were known and described.

But did it 'exist' at this scale? I don't think so.
Bank loans are still used for many more conventional small businesses.
Whitney Music Box
Cancers start when DNA is mis-copied. Typically DNA is copied to RNA, which is then used to generate protein, and there isn't usually a mechanism for that RNA to go back a step to become DNA again. I don't want to say it's impossible, or that there's no conceivable negative effects, but cancer seems like an implausible result from mRNA therapy.
https://archive.is/h7MNM also works.
Causality Is Graphically Simple
Upload a CSV or talk to support for a db integration.

"talk to us" everywhere instead of price info and documentation.

Feels very early, and not going to be useful to me until I can add a few different data sources myself.
Superfitt
Egészséges életmód, edzés és egészséges táplálkozás
> there are a lot of laws on the books in the U.S. that on their face appear to be unconstitutional and it is up to the courts to interpret them and rule on their constitutionality.

But what if the law is clearly 1000% prima facie against the word of constitution, but judges still keep deciding to okay it fully knowing of its unconstitutionality?
The credit bureaus have a difficult enough time keeping accurate information as it is already. This would be orders of magnitude of more data with sloppier providence. Whoever thought this up at the IMF isn't thinking about data quality issues, they're simply thinking in terms of magically knowing everything a potential borrow has been up to. GIGO.
I'm still on my first playthrough (and enjoying it) and am super disappointed to hear the other lifepaths are basically 15-20 minute prologues. I too was really hoping for my corpo playthrough to be playing it from the inside, lots of corporate espionage, dealing with situations with the full force of a megacorp behind me etc...
Design and Development
Never really heard about Concordia CS.

Some public universities seems to just be concert-hall sized lectures. Is it one of them?
>Deus Ex with updated graphics

It won't bring it up to modern standards by any means, but have a look at Deus Ex: Revision (https://store.steampowered.com/app/397550/Deus_Ex_Revision/).
There was certainly a lot cut, but already back in August interviews said that lifepaths wouldn't lead to completely different stories, but rather add a bit of a different flavor to the same over-arching story [0]:

> Your choice of lifepath will influence parts of your journey throughout Cyberpunk 2077, and each one will have an entirely different introduction to the same overarching story.

Tho it's a bit telling how one of the introduction quests is used as an example for how the lifepath choice makes a difference past the introduction.

In my 30 hours of playing I've had only one situation where my choice of Nomad seemed to make a difference; During a Gig at Kabuki market I could ask another Nomad there about the location of a person I was looking for.

Dunno how that quest would have played out otherwise without that.

[0] https://www.gamesradar.com/cyberpunk-2077-lifepaths/
It was Android and much, much worse than contemporary Arm tablets.
> Getting augmentations were meaningful choices which alter ways you can approach explorations (such as picking up heavy items blocking vents).

It's mostly through stats rather than augmentations, but Cyberpunk has a ton of this. There are doors you can/can't open, characters you can intimidate, obstacles you can get over, things you can hack... there are a lot of ways your build changes how you can approach the missions.
Founders (and early investors) don't necessarily have preference. The thing about founders and possibly key individuals is that they can be taken care of other ways in the earn out, even if their equity ends up hugely devalued. It's one of the ways deals like this can get made, and one way employees can get left holding an empty bag.
I've been a little out of the loop on how COVID vaccines were different than others. In case you're like me, here's a nice primer on "mRNA vaccines": https://www.cdc.gov/coronavirus/2019-ncov/vaccines/different...
Yeah, I'm so curious about what they were doing for the last 2 years. It seems like the artists have been working on the game for 5+ years: the world is huge and full of interesting and detailed environments. The graphics are amazing (on PC). But it's like the gameplay and open-world systems were written in the last year or two, and it shows.
>.....With application stacks being what they are and optimizations for Xeon so deeply integrated......

That is of course in the context of Server CPU design. Your mileage will vary depending your usage.

With the announcement from Marvell's exit [1] of ARM Server CPU it is now all but confirmed that Microsoft and Google are also working on their own ARM Server CPU. Which means all HyperScaler will now have a common interest to have Software running on ARM. And this will trickle down to every part of the industry.

It will take some time, depending on your scale, the cost benefits of switching over may be different. But there is no denying that Intel doesn't have a short term ( 2-3 years ) answer. And I dont see their medium term ( 4 - 5 years ) are any better. Their new Optane SSD is really exciting though [2].

And I am willing to bet all of these New Server CPU comers has absolutely zero experience in CPU forecasting, and risk averse enough to put down commitment on capacity, which ultimately leads to TSMC getting a bad name yet again for "Not Enough Capacity".

[1] https://www.servethehome.com/impact-of-marvell-thunderx3-gen...

[2] https://www.servethehome.com/new-intel-optane-p5800x-100-dwp...
Guess I'm one of the lucky ones. I'm 40+ hours in on PS4 with no major issues except for a hard crash every few hours. Which is SUPER annoying when it happens, but I'm not seeing a ton of glitches otherwise outside of little things like talking corpses.