skysight-inc/HackerNews huggingface dataset:
You seem so confident, but cite nothing (just like the comment you are referring to). However, I do note that all the symptoms noted in the comment above are actual symptoms found in survivors of severe COVID. I'm not sure about the proportions though, but is it a stretch to believe that patients who are hospitalized (by definition, severely impacted by COVID) very often have long-term damage?
A warning to those of you who easily cry: this piece will do it to you.
>Will the likes of Deep Blue and Alpha Zero kill competitive chess?

In a way it's led to more preparation requirements for serious tournaments. You can load up a board in any position and Stockfish will tell you the best possible move from that point.

Once you review your games in Stockfish/similar, it's honestly hard to think about how you would learn what you did wrong in the past, on your own at least. Unless you had a GM teacher, even your teacher may not be 100% all the time, but chess engines have gotten to the point where they essentially are 100% correct.
It's worse than that. The government has essentially unlimited (time and money) resources to throw into a civil case. Even the most wealthy individuals are at a severe disadvantage.

I'm not a legal scholar, but I find it bizarre the government can bring civil cases against individuals and corporations. They also do this to enforce environmental measures, a laudable goal. But as an ignorant layperson I prefer the government stick to defining and prosecuting what is illegal and stay our of civil law.
Very interesting.

It is illegal for a private company to help another government censor citizens?

It is not illegal for a private company to censor citizens.
Different programmes will place more or less emphasis on different things. For myself, this was a tiny part of a 4-year undergraduate degree and I probably didn't spend any more than a day or two on the topic.

What you say does sound right, but I think the other answers still have pedagogical value. Thanks for clearing this up, I now realize I need to brush up on this topic.
America is full of bootlickers.

The following quote is framed around the debate around social democracy in the US which you may or may not agree with, but the main point is how Americans happily accept a super-strong centralized state that does virtually nothing for them.

"""Americans are, of course, the most thoroughly and passively indoctrinated people on earth.

They know next to nothing as a rule about their own history, or the histories of other nations, or the histories of the various social movements that have risen and fallen in the past, and they certainly know little or nothing of the complexities and contradictions comprised within words like “socialism” and “capitalism.”

Chiefly, what they have been trained not to know or even suspect is that, in many ways, they enjoy far fewer freedoms, and suffer under a more intrusive centralized state, than do the citizens of countries with more vigorous social-democratic institutions. This is at once the most comic and most tragic aspect of the excitable alarm that talk of social democracy or democratic socialism can elicit on these shores.

An enormous number of Americans have been persuaded to believe that they are freer in the abstract than, say, Germans or Danes precisely because they possess far fewer freedoms in the concrete. They are far more vulnerable to medical and financial crisis, far more likely to receive inadequate health coverage, far more prone to irreparable insolvency, far more unprotected against predatory creditors, far more subject to income inequality, and so forth, while effectively paying more in tax (when one figures in federal, state, local, and sales taxes, and then compounds those by all the expenditures that in this country, as almost nowhere else, their taxes do not cover).

One might think that a people who once rebelled against the mightiest empire on earth on the principle of no taxation without representation would not meekly accept taxation without adequate government services. But we accept what we have become used to, I suppose. Even so, one has to ask, what state apparatus in the “free” world could be more powerful and tyrannical than the one that taxes its citizens while providing no substantial civic benefits in return, solely in order to enrich a piratically overinflated military-industrial complex and to ease the tax burdens of the immensely wealthy?"""
I guess this supports my point. It's a hard - and necessary - problem to address, and HTML and CSS are not very good fits for it.
Tech is probably as good a scapegoat as anyone in government is going to get right now, but I think a lot of the anti-trust issues have been building for a while now.

The lack of regulation is painful to see. Amazon Prime Video not working with Chromecast? A letter from the FTC could fix that among many other such squabbles, all the way up to real anti-trust problems that have been ignored for too long. A privacy law would do wonders if congress ever got it's Tech-act together.
7nm.
God bless Sci-Hub. Thanks for linking the full article.
How long does the account last? Are there any limitations?
This question inappropriately assumes that the Rust compiling design and performance are fixed to what is today, and in particular, that they are entirely inherent to the language.

There are a few interesting reasons why Rust compilation time is slow and Go's is fast. Here's a summary of the first: https://pingcap.com/blog/reasons-rust-compiles-slowly.

In theory, with enough time and resources, Rust could see an efficient compiler, but this is something that can't be predicted, as it depends on its future success, or, to be clear, the backing it will have.

In practice, the Rust Cranelift backend could provide enough speed (for debug builds) that compilation times won't be slow anymore.

Something to consider is also that compilation is a tradeoff between compiling speed and runtime speed (Golang's favoring compiling speed), so one can't have both ends of the the spectrum at the same time.
You've gotten off easy so far, but the get off ended.
Matrix is an exciting platform. I would love to see someone build a simple universal notification system on top of it.
That is how you win. You achieve the "big goals" via obsessive habits. But those things are not the same as "I've reached as far into my career, education, relationships, and economic gains as I ever had a passion to do". I'm not tired of coding, I do it every day and it is still rewarding. But that isn't a life goal.
Does anyone have any idea what this means to end users who just want to purchase a DJI drone?
A layman's speculation followed by a layman's (at least in terms of immunology) question: introduce a novel mRNA, cells produce novel protein, it is presented to the immune system as something to foment a defense again: vaccine. But the article talks about using this mechanism to replace a functional copy of a genetically missing enzyme. How is it assured that this will assume the opposite goal and not become another target for the immune system to guard against?
Solarwinds' Loggly and Papertrail Default to Sending Unencrypted Logs
everything is a coincidence, obviously. hence the title.

we can still form a pattern from available and known coincidences.

thanks for the links.
Huge aside but... if you like Tolstoy and Shakespeare reading Tolstoy's take down of Shakespeare is super interesting: https://en.wikisource.org/wiki/Tolstoy_on_Shakespeare

He specifically goes to town on King Lear and gets into some interesting discussions on how he thinks the earlier Lear Shakespeare referenced is structurally better.

Also reveals Tolstoy's own perspective on writing as a moral endeavor which he feels Shakespeare failed at, as if Shakespeare had a morality it was "people should be good, but not too good"
People are weirdly polarized over VR. It's seemingly a trend to knock it before trying it.

I think it's been somewhat of a walled garden for a long time due to price (headset + PC)... So a lot of people formed negative opinions about it before even trying it.
Interesting - thanks.
The specific example I had in mind was an acquaintance who held a doctorate from Trinity, Dublin. and it was quite a while ago. So no, I don't think devalued qualifications was the issue.
I'd say being messy. People just want to get things done, and when they're done in a messy way, they don't want to start over. It depends on their deadlines and how much are they being compensated for doing it the right way(TM).
> This is the list of what the EU is paying:

Oxford/AstraZeneca: €1.78
Sanofi/GSK: €7.56
Johnson & Johnson: $8.50
CureVac: €10
Pfizer/BioNTech: €12
Moderna: $18
Netzke – Client-Server Components
Sauce Acquires API Fortress; Adds API Testing Capabilities
It exists in varying amounts in different companies and departments. I don't work in tech, but I know there are some departments where I simply will not work because I would become miserable. There are other departments that have a lot of positive traits, that work well as a team and have good communication. Sure there can still be the odd bit of politics and dysfunction, but that is not the norm and it is not in excess either.
My Ken Williams Story
I’ve also heard these types of small (10-50 people, maybe more) companies referred to as lifestyle businesses.
I was an activist that blogged. Data gathering and analysis was exhausting. My efforts changed policies, socialized reforms.

Does your poor esteem for bloggers apply to activists like me?
Awww thank you! I really appreciate it!

I'm not using any visualization libraries. It's all just hand-coded javascript... I've been meaning to learn D3 for a long time, but I haven't gotten around to it yet.
Wrong. First, you have no uncontrolled covid spread to compare to. You are actually comparing tightly locked down COVID spread to a normal flu season. And COVID is still killing a lot more people. The closest example for an "uncontrolled covid spread" would be Bergamo in Jan-Mar 2020. Is that what you want repeated world-wide? The death rate there was astronomical.
The Elderly vs. Essential Workers: Who Should Get the Coronavirus Vaccine First?
We're constantly iterating on Element's UI, and the concepts are getting constantly de-weirded. For instance, one of the things many people complain about is that it's possible (and indeed easy) to end up with multiple DMs with the same person. So we're in the process of defaulting to "canonical DMs" (i.e. one DM for each pair of people). Others complain about the hassle of managing E2EE (verifying new logins; backing up your keys with recovery passphrases/keys, etc) - the Matrix equivalent of the Signal recovery PIN drama. We're going to be reworking that all (again) next year, too. So yeah, the UI isn't perfect, but hopefully we're working on it, and it should get better.

Meanwhile, the nice thing about Matrix is you can use whatever app you like - e.g. SchildiChat is a fork of Element Android, FluffyChat's good too, so use whatever floats your boat.
Most people don't hate pure capitalism. It's just that China is doing every single thing they can whether it's legal, grey area, or illegal... to get ahead. And their aims aren't just to be efficient. They are to use that efficiency to achieve their authoritarian government's goals.

So when you look at all of that together, it really is something that the "free world" should be worried about.

Most of the tech that China profits off of was developed in the west. Efficiency needs discovery for progress.
What a strange take. SSBNs remain the ultimate weapon and most naval warfare is geared toward either neutralizing enemy SSBNs or missile attack (a Burke can carry 5+ times more armament than a B-52 and stay on station for months). The Navy has a logistics arm and a spec ops arm, just like the other branches do, but their core capability revolves around SSBNs.
Adjuvants are not toxic, they're simply known to enhance the immune system response (so they are something that indicates danger to the immune system). The immune system is incredibly dangerous and destructive, and you really don't want to trigger it without reason. So injecting something unknown might not be enough to get the immune system fully alarmed, that's why some vaccines add adjuvants to produce a stronger response. RNA can be an adjuvant by itself, as it's also a typical component of viruses and the immune system reacts to that.

So the trick really is to design the RNA and the delivery system so that it produces an immune response of the right magnitude. Too weak and it doesn't work, too strong and it's harmful.

Antibodies that bind to your own proteins are filtered in an earlier stage in antibody production. Real viral proteins are also produced by your own cells, so that is never a factor by which you could distinguish friend from foe.
Devilering a great game is harder than it looks!
Every metric will be gamed
> If I were a medical worker, and they gave me shit PPE and told me that I'm not allowed to use my own - I'd simply ignore them until I was fired.

You'd not only be risking your job, but your license as well (as in, future employment in your field).
We should always remind ourselves that government is the best investor of first resort.
We did the groundwork for this with the ultra-low-bandwidth Matrix stuff last year: https://matrix.org/blog/2019/03/12/breaking-the-100-bps-barr.... But frustratingly nobody has picked up that work yet.
Possibly not relevant to your current simulation environment, but if your tech is generally focused on extrapolating from simulation data, I think there’s a market for this kind of thing in document parsing. Extracting tables, charts, text, etc from images, PDFs... paired with a document simulator could be powerful.
It might have been the trial for a different vaccine; I think it was the one someone on this site was participating in? But in that trial, the control was another proven vaccine for something most people don't commonly get vaccinated for.
On the contrary, a Pixel 5 is actually a fantastic phone. It's the smoothest-feeling phone I've ever used -- the 90Hz screen makes a huge difference. Tip: go to the developer options and change the animation durations to .5x to make the phone feel blazing fast.

Plus a Pixel integrates a lot better with non-Apple operating systems, both MS Windows and GNU/Linux. MS's "Your Phone" and KDE Connect are both great.
Generally the "rule" in English is the same as the one in German: a double consonant ensure the preceding vowel is pronounced the short way rather than the long way.

The saddest sadist, the matter of maters, and the bitter biter, for example.
Even there, you can make the software work and be secure, and still get away with loads of maddening practices and making software that just barely does what it does, waiting for the customer to fund a feature.

Is it a smart business move? Debatable (I'd argue overdelivering on a SaaS product also helps bring in new customers). From a moral standpoint, I find it incredibly difficult to justify penny pinching and filling hours with malpractices and bureaucracy.

And for what it is worth: personal experience tells, a lot of customers are quite accepting of faulty software, as long as the damage can be reverted and minimized. Even those in finance. Wouldn't be the first time I see people casually solve a bug that caused millions worth of damage.
I read a theory that powerful groups carry out these attacks to gain favor with Putin etc. There is never a direct order from above. It's just done, and if it's done successfully the intelligence eventually finds out, then Putin finds out, and they expect some favor down the road.
FIA develops “100% sustainable” biofuel for Formula 1
I don't necessarily recommend it, but dropping out of college for a year and working dead-end low-wage jobs got me to go back with a renewed vigor and willingness to focus. Subjects and activities I found boring and impossible to focus on suddenly gained a new weight that pushed me through my previous limitations.

Another poster mentioned it, but seeking mastery over the whims and desires of your mind is paramount. My anecdote above was basically that. My mind never stopped fighting me, begging me to be lazy and go play video games. But the inner acknowledgement that I had to succeed and graduate let me fight against it.

I also changed my environment, working out of coffee shops and computer labs, surrounded by other people studying and working their asses off. I joined the ACM chapter at my school and expanded my social network to include people who were working as hard as I wanted to. This provided mental sustenance when my personal discipline would wane.

I suggest listening and reading all of John Cleese's talks on creativity. The painful level of effort he describes is fundamentally related to these challenges.

Also, caffeine, copious amounts of it.
With things like Blokada and YT Vanced you can already do that on Android.

Amusingly, and much to Google's dismay I am sure, they have created an OS where you can make sure absolutely nobody ever gets payed.
The Shadow Request: Troubleshooting OkCupid’s First GraphQL Release
Some Big Sur users are unable to update macOS due to an MDM bug
I meant that they could create static (or static-like) sites in terms of what a reader would expect, ie changes propagate through a CDN, they have a CMS they can use to edit pages, etc. So it's not that the author wants a SSG necessarily, they just want something easy to use that creates websites, which is basically what Ghost and others do.
Good question. The article says:

> These drugs face the challenges of targeting mRNA to specific tissues and giving strong, lasting benefits without excessive side effects.

This innovation reminds me of Virginia Postrel's book The Fabric of Civilization: How Textiles Made the World [1]. Postrel describes several key technological innovations that propelled the manufacture of cloth from fiber farming to thread weaving to cloth weaving to cloth dying/decorating to distribution. Each innovation moved the bottleneck to a different layer in the value chain.

The mRNA platforms are ideal for vaccines but ultimately, the downstream safety/efficacy trials are the new bottleneck. There was a time when futurists obsessed about nanobots but these mRNA platforms are the ultimate nanobots, in my opinion. They can be configured to program biological cells to manufacture simple proteins in situ. This is a very powerful tool, but like the historical innovations in spinning and weaving, the technology can produced many orders of magnitude more potentially useful outputs than the rest of the value chain can use effectively (for now).

[1] https://www.basicbooks.com/titles/virginia-postrel/the-fabri...
If the death rates in children vs. elderly were reversed with COVID, all hell would have broken loose. There is nothing people are more protective over than their kids. Behavior would have been completely different.
> LGBTQ representation

Cyberpunk was not well received by the population it was trying to cater to with its customizable genitalia.

https://jygglypuffdaddy.com/2020/12/11/an-almost-exhaustive-...
That's just ranting on a theme. Americans value personal liberty (e.g. taxes, property, travel) while other value security (medical and financial).

So what? Which is 'freer'? That quote has made its socialist leanings obvious - government should care for us all.

And 'no substantial civic benefits'? Where does that come from? Water, power, highways, the mightiest cities on earth. Sure there are problems. But its nowhere justified in bashing American freedoms as 'not really free'. That's just 'No True Scotsman' at work?
On the opposite side: how do we effectively convince people this new type of vaccine is safe long-term? I'm not a biology person, so I trust the biology people when they say it's safe, but many don't.

My intuition is that many cancers can start when proteins are mis-copied, and mRNA therapy seems to rely on copying to work very reliably. Does introduced mRNA increase the risk or impacts of mis-copying?

Is there an ELI5 intuition for why mRNA therapy is safe and won't lead to cells becoming cancerous?
What's in it for the devs to blow the whistle here? It's not like a matter of public safety.
That preference would live with the link aggregator, not in the AMP spec. Where does it say that this was on any project plan? The idea does not make any sense.
People on Reddit are reporting long queues on the paid tier too.
I don't think it's due to corruption per se. Americans just have to be convinced to care about civil asset forfeiture more than they care about other things. Most people probably think of it as something that happens to other people who were probably crime-adjacent anyway (I don't agree with this line of thinking). If you got enough single-issue voters who cared about civil asset forfeiture, it would go away.
Yes, but at least most VCs try to do it with an exit. Private Equity is far worse IMO
A waste of a comment :)
There's a lot of great stuff at SemiAccurate throughout the years that details what went wrong at Intel and why. Unfortunately, you have to pay for it because Charlie has a practical stranglehold on semiconductor inside information.

And Charlie is a bit of a polarizing figure. He's gotten some things hilariously wrong, but he's also been dead on the money for a lot of issues, and his documentation of what's happening / happened at Intel is pretty much crystal clear.

You could probably browse through all the 10nm articles there and get a good idea of what happened without purchasing a subscription, if you have a decent knowledge of the semiconductor industry.

EDIT: If you read though these articles, even the parts that are available to non-registered users, a pretty clear picture starts to emerge - https://www.semiaccurate.com/tag/10nm/
> if the risk/reward means we should attempt earlier roll out

you still need to make sure the vaccine actually works in trials and has no severe side effects. It takes one, and only one minor vaccine scandal to completely blow the trust of the public in public health.

There is no linear risk/reward when it comes to vaccines. You need to be incredibly confident that they are safe or else you're going to screw yourself possibly for decades.
>Many were increasingly of the opinion that they’d all made a big mistake in coming down from the trees in the first place. And some said that even the trees had been a bad move, and that no one should ever have left the oceans.

The internet is great, how we use it may not be.

I don't have twitter, rarely delve into comment on most news sites and Youtube. Browse and sometime comment on Reddit and here. I prefer here, less shouty.

When you are able to talk to thousands or millions of people without having to have connections, its a wonderful thing. The friction arises from a number of things; contrarians who love to argue, trolls, governments/companies who are trying to influence opinion but also people who have a genuine different opinion and are unwilling to listen to the other side.

I did enjoy the internet more when it was younger but at the same time, there was a less diverse population on it then.
I had several voicemails from passed friends ~15 years ago and I switched phones and lost them somehow in their system. I cried a lot that day.
Is there any risk of a "doesn't produce immune response" failure that would make it unsafe to start giving to healthcare workers immediately? Could it make later vaccines ineffective?

I'm sure that it would ruin the data for later vaccines, but if high-risk people just take each new vaccine as it starts trials, their data doesn't have to count towards the actual trial.