skysight-inc/HackerNews huggingface dataset:
The mRNA vaccines do also transmit the shape, as the encoded viral protein does get expressed in the cells. And the shape does get recognized by the immune system when that protein is secreted from the cell. But there is also a shape-independent mechanism that works on the sequence alone. The proteins in a cell are also chopped into tiny pieces and presentend on the surface. That part could not distinguish between different folded versions of the same protein like with prions.
I am certain GDP has been nobody’s primary concern in NZ during this time, but -2.2 % is not bad considering how international NZ’s economy is. For comparison, UK is at -9.6 for the same period US -2.9 with a far higher human cost.
I've played through this section before and after the patch and I have to say that the original seizure inducing effect looked a lot cooler. I don't mind it being replaced with a milder version, and I would have never noticed if the game released with it from the start, but having seen the original I'd like an option to switch back to it based on just how cool the flashing lights looked.

> you shouldn’t be intentionally showing a seizure-inducing pattern of lights

I think the intention was to show a cool flickering that looks like it'd mess up your brain (which is somewhat the intent of BD in game). The fact that the flickering also caused seizures, is clearly an oversight.
Yes, later on in the process. I’m not too concerned about specifics, but I’m looking for whether a company values developer productivity. There are many good answers to this, from “use what works for you, here’s a budget”, through to “we use this very specific set of tools but have put loads of time into making them work well”. The bad answers are usually things like “IT sends you a laptop”.
It's still confusing because the table contains "net tax obligations" which appears to be the taxes due if one were to liquidate the whole kit and caboodle at once.

Instead, I think it needs a another column for additional gross income for purposes of tax liability in year of liquidation. As I understand it, when you exercise your options at $1.20, you must pay $100k to exercise, then you own taxes on the $20,000 in gains. When you exercise at $20, you must again pay $100,000 to exercise the options, and also pay taxes on the $1,900,000 in gains.

And this fact is what causes early employees to walk away from so much money. There's a huge difference in viability of paying the tax bill on $20k of income vs. $1.9MM when the underlying assets are illiquid, and cannot be sold in part to cover the bill.

Most people will be able to come up with another $6,000 or so to cover the taxes from an early liquidation. But it's substantially more difficult for most to come up with the $500,000 to cover the tax liability in the second case.
"Abstraction extraction is an expensive transaction."
Yea, this also happens periodically, granted at lesser degrees. Incorrect projections, retooling, mundane management changes that HAVE to make their immediate mark on production and other crap. Given the ever so minor hiccups to the global supply chain we experienced throughout the year, on top of a plant catching ablaze... this isn't that surprising. This too shall pass.
Good point about the data being noisy, wasn't aware of that. If we take an entire year the core of my statement still holds, although more weakly. Tesla is a competitor, but not market leader. Other cars sell way better. Check the image at the bottom of this article: https://insideevs.com/news/452441/norway-plugin-car-sales-oc...

3.2k Tesla model 3's sold in 2020, but it's only at #6, with #1 to #5 each selling more than that, like e.g. ID.3 with 4.4k vehicles.
Because the tax treatment for options is far superior, especially if you’re relatively early.

You’re paying 40%+ in taxes for RSUs as soon as you vest. If you’re able to early exercise stock at a startup you owe minimal taxes when you join a company and then when you sell you’re just paying long term capital gains taxes which is a lot lower than 40%.
U.S. charges China-based Zoom executive with disrupting Tiananmen commemorations
Hey! I’ve used both. They’re actually not competitors (Compound integrates with Carta). The difference? Compound sells to shareholders (Carta sells to companies). Compound provides holistic financial management services (in helping me manage my entire financial stack), including startup equity. The biggest benefit is they personalize everything to my situation (it’s a holistic experience). Would recommend trying it out!
One thing that stood out for me as well was that someone else indicated that, in general, the only requirements were the exams. Most of the engineering classes I took had weekly problem sets that, yes, took at least a solid evening to do.

The way my undergraduate did credits was the (theoretical) number of hours a week they took between lectures, lab, recitation, and study/problem sets. Typical classes added up to 12 with usually 4 hours of the first 2 categories and 8 hours of the last. Classes varied but that wasn't too far off for the typical class. (Though there were some real time sink outliers.)
As a counter-example, all of my friends who are playing/talking about the game spent the first several days after its release playing the game in all of their offtime (including some taking the day of release off) and haven't really talked about the reviews at all. We have occasionally talked about funny bugs or thing we wish were a little different (wish it would zoom out the minimap while driving, for example), but most discussion has been positive
The Unseen: a collaborative mystery story from Storylocks
I'm not arguing that you accept attribution blindly.

That being said, asking for attribution with evidence right now is absurd. No one, except the attackers, knows the full depth or breadth of the attack. To make a positive id at this moment, and explain how investigators are attributing responsibility is reckless. Asking for evidence behind attribution at this time is essentially flamebait. If you doubt the attribution it may be better to question the record of those making these accusations and what they stand to gain by making them.
Two other unusual and clever language constructions are xkcd's Up Goer Five a description of a Saturn 5 rocket using only words contained in the 1000 words of basic English, see [1], and
Gadsby by Ernest Vincent Wright, a novel of 50,000 words without using the letter e, see [2].

[1] https://xkcd.com/1133/

[2] https://www.abebooks.com/books/gadsby-lipogram/
Superdense coding allows sending two bits of classical information by only sending one qubit physically. Ideally this will double transfer rates. And in any case it provides another "modality" for data communication, which may provide tradeoffs that have benefits in other directions.

I'm pretty sure (haven't been in the field a while) that superdense coding the densest coding that one can gain using quantum entanglement.

https://en.wikipedia.org/wiki/Superdense_coding
Man, for a nation founded by rebelling against a tyrant, and known for its can-do mentality, you sure have a pretty defeatists attitude when it comes to defeating authoritarians...
I don't think early AirBnB employees think their equity was a terrible deal. 0.01% of equity is now worth $9m.
Yeah, I like this approach, because the "what is a word" knowledge is a nice piece of common functionality that doesn't make sense to repeat. It's unlikely to change for just one of those two functions.

In my example, it's less a "core piece of knowledge" that people are trying to DRY, and more just a "common sequence." Someone sees a bunch of different places where we have a sequence of calls like A, B, C, D.. and says "oh this is a shared method I can extract" even if there's plenty of ways that in the future you might want to do A, B, C, E without D. And so then you pass in a bool, than another one, and you have a centralized mess...
VC is like visiting sports clubs, finding the best candidates, and overdosing them on steroids. VC hopes the ones that survive will become profitable enough to pay for the ones that it killed.
To be fair, the death rate also includes people in terminal condition that ended up catching covid before dying.
According to lord PG, Start up = Growth

http://www.paulgraham.com/growth.html
mAb = monoclonal antibody
I agree about the importance of tradeoffs. Looking at the historical perspective, though, the reason that every principle is a tradeoff is that the principles that are uniformly worse get discarded.

For instance, structured programming (building code out of blocks with structured control flow rather than a pile of gotos) was victorious in the 1970s. Nowadays nobody considers the tradeoffs of using if-then-else versus gotos; structured code is the automatic choice.

Self-modifying code was very popular in the 1950s (since it was the only way to get many things done), but essentially nobody uses it now.

Modularity is another victorious principle of software development, winning out over big blobs of code with global variables.

Using a stack for subroutine calls used to have tradeoffs, but now nobody would consider an alternative.

Looking at the long perspective, there is real progress in software development (although slower than I'd hope).
What about all the extra work every departing employee (either voluntarily or not) has to do in the 90 days after they leave to decide whether or not they want to exercise their options, and if so be forced to spend and risk potentially lots of their own money to do it.

Founders spend a lot of time and effort making sure their equity is right and structured they way they want it, they should at least put in the minimal amount of effort to ensure their employees' stock compensation is structured in a way so it isn't going to waste.
Eh... Yes, it requires concentration. But it also requires really good working memory and visuospatial skills. These don't have particularly broad applicability in real life.
Only if you're independently wealthy enough to exercise and pay tax now.
I used to wonder how cyberpunk scenarios of for profit police who would only investigate crimes if the victim paid them could ever come about. Thanks for clearing up this confusion, I never would have guessed that it would be motivated by warped social justice, not end-game libertarianism.
Good point. So they simply were not able to ramp up faster than it took for the existing manufacturers to start catching up and leveraging their scale better.
I meant in terms of whether a backend constitutes a SSG or not. What's your point, I didn't understand it?
The part that appeals to me is that they're using a smaller than nodejs (and Electron for that matter) local server to do so! CORS means something has to proxy, so seeing the existence of what I'm assuming is a minimum implementation is really helpful. Obviously I'm not hanging out in the right slacks or subreddits. ;)
Cyberpunk uses fundamentally different graphics pipelines that rely heavily on temporal information. On 720p you can already see artifacts such as fizzling, smearing and blur due to aliasing of the TAA implementation, as well as other post processing like volumetric lights that also require high resolution scenes to work properly. That is why a 540p is more detrimental to this game than those other.

https://youtu.be/C5pHpQqhmR4 3:20
https://youtu.be/mVWJPYKCMco 14:30
Do prions typically occur because of a defect in the RNA or are there just certain protein structures that have instability in how they fold?
mRNA is not the only type of RNA that can be delivered. Another type could be interfering RNA targeting endogenous coding or non-coding RNA molecules.
Nope, no data loss issues with iCloud Drive files directly (or Dropbox).

My hypothesis is that Books does something wonky with metadata for extra sync logic, like it depends on reading the last "last page read" record but then sometimes fails to write that, and then loses the pointer to the new version altogether. I can't be sure, but I can't think of any other explanation.
#1 is not at all objective. I would say a world that revolves around deception, fraud, sex work, black market body modification is definitely in the realm of "Mature RPG".

#2 was mostly a lie

#3 Meh. You level up, you customize your character based on perks and skills. You get items that you can customize. This one seems fine.

#4 Is fair I think. Stealth + hacking + fighting + talking. You can build your character to be your exact playstyle. You can do several playthroughs and have totally different styles.

#5 I think is fair, although I might not call it "gigantic". There are a bunch of weapon types, a lot of upgrades, and then a whole world of body modification and quickhack tools to play around with.

#6 is obviously a lie, given the launch.
> I'm not sure if the "This isn't DRY" is the best fight or "Sometimes DRY is not the best".

The problem is that when people believe this is DRY, they then tend to oppose the "real" DRY as well.

Likely we'll have to give another name to the "real" DRY principle. In general, I've always felt that catchy names/acronyms are a bad idea for anything (e.g. free software, open source, pro-life/choice, etc). Almost all of them end up being used in ways that were differ from the original intent.
1. One advantage of the mRNA vaccine is that each strand of mRNA is translated to protein many times before it is degraded. So less vaccine has to be manufactured and the dosage can be smaller. Another advantage is that since it lacks proteins you do not develop immunity to the vaccine itself, meaning that you can receive multiple booster doses.

2. Yes, the mRNA is ultimately degraded. But part of the process of developing the vaccine is fine tuning the precise rna sequence in order to achieve the desired half life.
Okay, layman's speculation: Given we can co-opt cells to manufacture proteins for us like this, and given we can predict what shape of protein an mRNA strand would produce, does this open up all sorts of potential in medical treatments? Tear it apart, HN.
probably because of the type of programming i do (business intelligence),
live environment doesnt mean much to me

most programs run, and finish, and updating most programs while running, is not something important, you can always update it and run it again

for long running processes like servers
well again,not really sure what this means

but i deal with database management systems, and i mean you can update a stored proc, without shutting down the server, you can of course update the data etc ..

as for the dbms process itself, i am not big on dba stuff,but most databases allow in-place upgrade , but usually you can to disconnect everyone while doing it

as for large website, like facebook or anything else even a lot smaller in scale, those are obviously not a single program .. and most likely they just restart services to pick up updates, and use a form of load balancing to work will go to servers that are not restarting

So in summary, this notion of live app, seem more theoretical than real to me
I recently watched the movie Angel Has Fallen on Netflix. The movie starts out with an assassination attempt on the president by a swarm of drones armed with explosives. The secret service agents were (not surprisingly) completely ineffective at defending against these drones using their hand guns. Just a fictional movie, but was still pretty terrifying to think about.

https://www.netflix.com/title/80190284
580 Covid-19 patients in Seoul waiting for hospital beds
75 years? It's had a mystique for over 1000 years (going back to the Islamic golden age).
I would think that depends on the type of commercial software - if, for example, it's used in a large bank where faulty software could screw up a few million customer accounts - anyone who rolls the dice with that will soon be jobless. THAT software (application, OS, utilities, etc.) is usually VERY well tested.
You can go with larger nodes and larger power budgets for avionics and other electronic stuff in battlefield machines.

OTOH you'd rather be top-notch in your communication equipment, low-power sensors for reconnaissance, etc. In some areas, having a US-controlled 7 nm fab may matter even for DoD.
"Proper weight" is subjective. Disagreeing with dfxm12 doesn't constitute dishonesty.
> staff of 1

Err no, it might look that way sometimes so that it seems authentic, but most major youtubers have staff. They are way more lean on expense than the TV pundits but still!
y = m * x + b

can refer to the distance a car has traveled over time at a fixed speed with a starting point as well as the cost of ordering a certain quantity of an item with a fixed shipping cost

that's my best attempt at an example
Ultimately, though, the blame does lie with the consumer. Companies seek profit, that's inevitable. The decisions of consumers is what makes it profitable to release unfinished games, and sell hype instead of a product.
Not really. There has been a long tradition of mostly shit quality journalism available for "free", along with some refurbished agency reporting, true. However, the quality journalism for the most part was still paid, as in buy a paper or magazine or a subscription, if you want reliable and regular in depth journalistic reporting and/or investigation (with some exceptions, of course). That really only shifted when publishers en masse put stuff on the web for "free", financed by ads.
These kinds of abstract code discussions almost become immediately absurd because, for it to work, we have to be imagining the same hypothetical codebase. Yet we never bust out concrete code. It's funny.

But the outcome that you're lambasting so rudely (really? "terrible idea" when we aren't even looking at code?) is still often the best outcome.

Some rotting, bugless, duplicated code is some of the easiest code to work with. It's the code you wish you had when you're debugging the complicated failing abstraction that GP wanted to avoid. The most damning thing you yourself could say about it is that it was taking up space.

In fact, you seem to be making the exact reverse argument of GP: that some duplicated, unabstracted, bugless code poses such a risk ("rot") that it's a "terrible idea" to not immediately merge it into one frankenabstraction.

When this happens in an argument, usually you both are imagining an absurd extreme that's opposite of the other's chosen extreme. And you actually are in agreement, as you'd both go "oh well yeah, if you go to that extreme, then I'd definitely agree with you."
> when referring to multiple federal circuits and the supreme court, their result absolutely is the reality.

> the more people bring these half baked cases in front of stupid judges, the more they keep crystallizing the reality.

Honestly, common law kind of sucks.
Thanks for the kind words about XState (creator here)!
I mean.. they can say that all they want, but they're a game studio that releases one game at a time. This game was "supposed" to release 8 months ago. Financially speaking, it just doesn't make sense that they have any room here.
Jeez, I made $99k last year and saved more than $25k and I AM an idiot with my money (I consider my lifestyle to be lavish). So I suspect it's more the "making a lot of money" part instead of the "not being an idiot with my money" part. Absolutely nobody is going to "not be an idiot" themselves to a six figure loan payoff in a few years on a 30k/year salary.
Create your own blob opera track
Service is part of the experience when dining out, so I think it makes sense to include that as a factor for restaurant reviews. Of course, the platform should separate out food from service
> It's possible though that not all aspects of security can be addressed by formal methods.

Well, one can always devise some well-defined model in which you can prove stuff. So nothing is ever unreachable.

> There's the issue of side-channel attacks (like SPECTRE), which are not easy to model using formal methods.

SPECTRE is not an error in programs, it's a breach of contract of the CPU (what shouldn't be observable actually is). I'm pretty sure formal methods would be of great help to design clean interactions between a speculative engine and the cache hierarchy. See eg https://plv.csail.mit.edu/kami/ from umbrella project deepspec.

One very common side-channel at program level (and probably one of the most important) is timing side-channel (and all derived: power draw, noise level etc). This one is "easily" solved (in the sense it's not an open research question): have constant-time function types. It's not hard discriminating between what's constant time and what's not: don't branch on input and execute only constant time primitives.
There are some, but also SanDisk, Dell (rebranded Toshiba), etc...

I've had pretty good luck with everything so far, knock on wood. The 1.92TB drives I mentioned are SanDisk CloudSpeed Eco II, and they have been pretty good. What's really impressed me are the Dell/Toshiba write-optimized 1.6TB drives I picked up. Pricey, but excellent performance.

I have a few I think 240GB Intel drives I picked up as well. They initially had some of the problems you're referring to, which for me was not showing up after a warm reboot, but they haven't done that for a while, so I'm thinking it may have been fixed by an OS update.
How Hong Kong Became a Testing Ground for an ‘Anti-Facebook’ Movement
Just use "<center>data</center>"

seems to work every time.
nitpick: virii is wrong.

The latin plural of 'virus' does not exist. It is a nebulous, uncountable concept to ancient rome. Like 'malaise' or 'ocean' (we can pluralize oceans in english, but hopefully you can imagine that a language would treat it as a concept for which the concept of pluralization doesn't make sense).

You'd think: Hey, it's `-us`, I know that one, it pluralizes to `-i`, but, no. There is no plural. It's a rare form that also ends in -us but doesn't work like most of the words you know derived from latin that end in -us.

But there is `vir`, latin for 'man', and the plural of that is viri.

So, 'viri', as in 'the latin pluralized form of virus', is dead wrong.

There is no -ii ending in latin. At all.

The plural of 'virus' in english is 'viruses'. Any other form is stupid. Sometimes language does that, but surely you'd agree that something like 'irregardless', whilst somewhat common, sounds very unprofessional. virii is the same way.
Thanks for all your explanations here
On the Spanish Flu specifically, the evidence indicates most people who died were killed by secondary bacterial infection, not the virus itself[1]. This was the result of a combination of poor hygienic conditions and lack of antibiotics. Considering that, I think what we are witnessing with SARS-CoV-2 is about what the Spanish Flu would look like today.

[1] https://academic.oup.com/jid/article/196/11/1717/886065
Books Not Sold by Amazon
There are many who argue against lockdowns, but I haven’t yet seen an argument for that approach with an example of how it could look (for death toll and the economy). Has any country managed both those things without a lockdown?
A hand waving “that approach could never work in X country because it’s so different there” seems the standard response to any strategy that has been proven to work.
It's convenient if you have one. If you had one for each financial institution you deal with, it might be a different story.
Nice I'll take a look!
I suppose that "hypothetical sci-fi" could be sci-fi that could be written but has never been
No. He spent money to have people murdered (unsuccessfully.)
Seems to be working well so far for COVID vaccines. We're about to witness a very large scale test though.
How to Write a Terminal Multiplexer with Rust, Async, and Actors
This article is the first CPU review I've seen that lacks both benchmark numbers and information about the manufacturer/process node. Is there a more technical document describing the Altra?