skysight-inc/HackerNews huggingface dataset:
What part of justice for murderers, tearing down idols of people who fought for slavery, and social shaming of people who espouse racist ideologies do you find to be wrong?
You're probably right, but it's annoying we need to apply this perfect regime just to fall asleep.

Why can't we just be tired in the evening? I have friends who would fall asleep on the couch while watching a movie if it went past 11pm. Meanwhile I have to do some bullshit ww2 pilot exercise just to fall asleep at 1am.
The browser support for these APIs isn’t very good
Please read my post a bit more carefully. I’m addressing the “acceptable” part, not the legality.
Mocking Tony Hoare - bold move:

https://www.infoq.com/presentations/Null-References-The-Bill...
Alibaba's Facial Recognition Technology Specifically Capable of Spotting Uighurs
As someone who architects FE codebases for a living I both agree and disagree with you.

React hooks definitely threw a wrinkle in the testability of react components. However, the ideas around how the FE should be tested has changed to the point where current thinking is that integration tests are the most valuable tests you can write. Testing what a react component does in isolation of redux or its side-effects is easy to do and also not incredibly useful.

Furthermore, many modern codebases still use redux. I still advocate for it. Using hooks and redux are not mutually exclusive.

I wish there was something better than hooks, it’s very easy to forget a dependency or get into infinite loops, but they do make life much easier. No more mapStateToProps or mapDispatchToProps HoCs. No more “smart” vs “dumb” components. No more function/class components. There’s only one component.

Also, we are seeing an increase in “headless” react libraries, where the logic of some functionality is disconnected from the visual design of a set of components. It makes composition, extendability, and maintainability much easier.
Microsoft Hit in SolarWinds Hack, Software Used to Distribute Attacks
Probably a similar percentage as the people with drinking problems who will tell you to abstain.
Meaningness draws out the essence from Dzog Chen and Ati Yoga to point to the attributes which an enlightened tantric society would create in individuals.

Enlightenment brings aesthetic changes, "mountains and rivers without end", not only moral ones, and these new aesthetics answer many of the critical questions left by post-structuralism about the implosion of meaning in relativism: while reality may be relative, the beauty which emerges from the open, curious, aware mind of the tantric practitioner rebuilds meaning-ness as an aesthetic value.

(David Chapman thinks this is an acceptable description)
5G, Transparent Solar Panels, and the Future of IoT
> I hope this is a good demonstration of a hands-off approach at Microsoft in regard to company culture.

I might 1‰ buy that if they restored the Widevine repos they snuck down for Google under cover of the controversy caused by complying with the MS-funded RIAA’s quasi-legal youtube-dl takedown request.
Plenty do make 60k and 300k is pretty far from being "typical" in Montreal.

I agree though that 60k isn't typical, that would be close to the starting salary. I'm still new though, so couldn't say what's typical, but I think 80k would be a pretty good bet.
What they are saying is that in a hypothetical communist/socialist society, even if the entirety of production is organized by workers, it doesn't mean that they aren't going to be productive in actually building stuff, nor that they aren't going to get stuff done.

How that relates to your argument I don't exactly know, but I guess it could be interpreted as saying that even if you admit that philosophy doesn't mean that you can't produce ""profit"" - especially if it is limited to software.

Also, in theory, you could be 100% accept communist philosophy yet operate a for profit business.
I'm not an expert, but I think the PCR page will help: https://en.wikipedia.org/wiki/Polymerase_chain_reaction

basically for PCR (enzyme based) it's sort of "unzipped" down the middle and the base pairs match a specific way which is how it's duplicated.

The rest I can't answer but I hope this was as fun a read as it was for me the first time. It really is insane to think about.
Thanks (very belatedly) for the breakdown! It's one of those things that makes sense in detail but still feels surprising in aggregate.
> At GitHub, we want to protect developer privacy, and we find cookie banners quite irritating, so we decided to look for a solution. After a brief search, we found one: just don’t use any non-essential cookies. Pretty simple, really.

Now if that realization just would dawn on other websites as well...
Teaser Marketing.

You'll be told (and told, and told, and told!) when the 'mystery phase' of the marketing campaign is ended.
I think amazon does this because they want to commoditize sellers and make them barely noticeable on their page. A bunch of reviews about one bad seller that they remove will reduce sales for an otherwise ok product. Maybe make 'seller' reviews upfront? Hard to say.
Netscrap – Email Joke Archive
I guess you are right, but to me even streaming videos are downloaded to your computer. I also have seen the 30% number of other sites so I thought it looked reasonable.
> I think it would be totally fine and safe if “nil” is identical to an empty list in every scenario

Yes, I agree. But even in Scheme, that's not the case. I'm not familiar enough w/Go to comment - I'll have to check it out.
1.

The key to this is understanding that the reads or sequences are long, and the slicing happens at somewhat random locations, such that your reads all overlap with each other (of course in reality it's more complicated than that, due to a bunch of long non-coding sequences and repeating sequences, but this will be mostly true for interesting parts of the genome).

Therefore your mental model of A, B, C is not particularly useful. I would replace it with the following example:

QWERTYUIOP ---[gets chopped up into]----> QWERT ERTY UIOP WE QWER TYU QW

Note that I used the terms "read" and "sequence" interchangeably here because the general notion is the same. But these two words refer to two different things.

2.

Histones are proteins. You can get rid of them simply by adding proteases to the mix. Proteases specifically break down proteins and leave nucleic acid sequences intact.

A commonly used protease is Proteinase K, which you can just order online here: https://www.sigmaaldrich.com/life-science/metabolomics/enzym...

You can also buy kits for specific applications: https://www.sigmaaldrich.com/life-science/molecular-biology/...

Once the histones have been digested, the DNA can be extracted, purified, amplified, etc, at your leisure. A full treatment of this topic would fill an entire textbook, so I will spare you the details.

3.

I'm not sure what this question means, but if you can rephrase I might be able to answer.
> For example I feel quite helped when a review for chocolate mentions that the chocolate arrived melted -- this is not a review about the product intrinsically, but is still very helpful for deciding whether or not to buy the item

So this could go either way. First there are often multiple sellers for one item on Amazon, to have reviews reflect the shipment or seller experience would kind of invalidate the feedback about the item. To ask Amazon to revamp their entire feedback system is quite an ask and clearly not what first comes to mind from reading the title of this post.

Secondly if some users are being encouraged to leave a positive review for money that's a morally offensive act by them as well, which no one here seems to be pointing out so far. It's not too dissimilar to lying about something and then asserting that someone pays others when they lie and it's really their fault. Lying is bad in itself.
Process automation startup UiPath files for IPO expected in first half of 2021
This isn’t about using a gender neutral pronoun with respect to a specific person. It’s about English-speaking people trying to change the label used for an entire group of mostly immigrant people by slicing and dicing a Spanish word and adding an English ending to it.

It’s like if I started calling you “Swedix.”
I bounced a bunch of times too for similar reasons.

Is it worth checking out? emphatic yes

Summarize? I will try, and probably not do a great job; I'm still digesting it.

The world is both "nebulous" [1] and patterned; observed patterns aren't really out there so much as a combination of "there" and in our mind. Some of these patterns are incredibly useful. One pattern is "the rational / modern world view", which lets science work. It is very good, but not complete.

Post-modernism noticed that no pattern is a perfect fit on the partially-nebulous world, and went nowhere with that, and ended up in a nihilistic, bad place. That isn't good.

The goal is to see patterns as useful, conventional truths, not ultimate truths. Then you can pick the right pattern / conceptual framework with which to approach a given situation.

[1] https://meaningness.com/nebulosity
Yeah, I guess this was probably going on even in some of the sports I played as a junior, like tennis -- it's just that I was never near the top tier, where that level of expense would begin to seem possible/necessary.
61% of iPhone users said default privacy settings were a significant factor. Half of iPhone users didn't know about IDFA. 61% of the half who did didn't know how to disable it.[1]

[1] https://foundation.mozilla.org/en/blog/what-half-of-iphone-u...
(2019)

Previous discussion: https://news.ycombinator.com/item?id=21284669
Hahah exactly, like Apple don't have the resources to support multiple installs and have to sacrifice one method in the name of stability.....
Could Not Answer
Vaccine Development, Testing, and Regulation (2018)
I agree with your points, except your reluctance to compare this on any level with the Third Reich.

While of course the nature and the extent of the crimes committed differ drastically from one another, there is still an interesting comparison worth drawing between how the legal process was corrupted in both cases in order to facilitate their respective misdeeds.
My biggest criticism of the book is that it didn't address oversleep. Where did you find that bit of info?
Difference Between Nicad NiMH and Li-Ion Battery Cells
Did anyone notice how in the code listings, the O's had slashes through them to distinguish them from zeroes, instead of the other way around? I wonder when it became a standard to slash the zero.
If you wanna make that change you've gotta be running the marketing department.
Show HN: Cleanup Google spreadsheets data with SheetsRefiner
Hey HN folks,
I built a little tool to help google spreadsheets users to clean up their data, the existing functionality includes duplicates removal, blanks row and columns removal, and case converting.

The existing tools either needs to be paid or hard to use. SheetsRefiner is a FREE addon to help people manage their spreadsheets data efficiently!

The addon can be installed here
https://workspace.google.com/marketplace/app/sheets_refiner/...
The newest Mac OS for a 2008 Mac Mini (A1176) is 10.7.5. It should be possible to boot from USB by holding option when it starts.

Some versions of Linux will work with the 32-bit EFI, but maybe not the latest versions. Try burning Ubuntu 10 to a CD, and you can probably get it to boot (holding option and choosing the disk, or holding C to boot from CD).
Learn at what moment your defenses are down so that they can sell you stuff, presumably. Isn't that the general assumption about tracking?

Or sell your data to interested parties. Maybe if you liked certain GitHub repos, you are more likely to vote Democrat or whatever.
(I should say - I was compressing into two tweets, so a little detail is needed)

1) the mind's model of reality is relative, but we can only ever model reality as a whole inside of our own minds - reality as a whole is unknowable, even in principle.

This doesn't mean we can't know, for sure, quite a lot about specific subsets of reality: "is there milk in the fridge?" has a good, precise answer, but "what's it all about then?" does not.

But our answers to "what's it all out then?" shape our ideas about our lives, which in turn shape our behavior. So our answers to these "questions without answers" actually heavily impact our lives over the long run.

2) Meaningness is an aesthetic value in that it is perceived in things and situations, and can be created intentionally at times. The sense of purpose and significance, of rightness and beauty, may be fleeting, but they are as objectively real as musical harmony but with this principle applied across the entire field of awareness. A similarly broad concept might be "well-proportioned", which can apply to almost anything in almost any area, and "you know it when you see it."

How's that?
I know I'm the exception but as a privacy oriented user I hate this. There are services that try to track me across the net when I'm logged in so I never log into them except in a private window. This works great when my browser has the name/password saved because I go to the site and its one click to login. It sucks though when it's email login. I now have to click "login", wait 10 second to 3 minutes for the email to arrive. Copy the link from the email to the private window. It basically means I avoid using that site most of the time. (Medium)
The concern with Pocket is primarily, IMO, that the service wasn't and still isn't Open Source, which is a hard sell for a browser that champions user control.
sorry for the non-sequitur, are you @leashless on twitter?
You have a far better impression of US agencies than I do.
> This is English speaking folks that have adopted a Spanish word and are now making it gender neutral by skipping the last letter. They are under no obligation to continue to follow the the original language's grammar.

Don’t you see how that makes it worse? The English word-Latin—is already gender neutral! Americans adopted “Latino” as gesture to the large number of Spanish speakers living in America. It’s not just a borrowed word Americans happen to use, it’s a word used to refer to a large Spanish-speaking minority group living in the country.
I am, yes. And I love chord keyboards, I used to have a Microwriter AgendA, and I still miss that user interface.
Ethical Employment Contracts Instead of Ethical Licenses?
This happens all the time with Amazon products from smaller brands/sellers. Amazon has also blocked reviews pointing out when a product is counterfeit, which I have experienced firsthand. I'm helping a friend try to return fake Bose headphones purchased on Amazon now.
For 1), the average person here might be better equipped to answer than the average biochemist! Sequences are put back together with de bruijn graphs. Small sequences are compiled into continuous segments based on their overlap. The key piece you might be missing is that there are many many copies of the same genome, randomly fragmented so with luck (or careful experimental design) you’ll have sufficient coverage to complete chromosomes. There’s still lots of tricky regions though.
Ask HN: Book recommendation for embedded software development
Hi, I'm a fresh grad from an EE program but with substantial informal, extracurricular experience in embedded software.

Now working in a role which includes a bit of embedded development.

I'm looking for a text which makes recommendations on best practices/design patterns for embedded software, especially in a high reliability/safety critical environment.

Ideally this would be an intermediate level book, nothing to do with Arduino etc.

Any recommendations or pointers to other resources would be appreciated.
Institutions and professionals don't seem to agree. For example, Microstrategy chose Coinbase to acquire over 40,000 BTC recently. [0] Maybe there are some aspects you're not considering. Seems difficult to believe you know how to spend their money better than they do.

[0] https://blog.coinbase.com/coinbase-is-helping-corporate-comp...
> Compare with the alternative

That's not the alternative. You are constructing a false dichotomy.

The current pay structure and a GDP-indexed pay structure aren't the only alternatives.

But, Even ignoring the false dichotomy, this...

> Literally every top decision maker in federal government has a massive financial incentive to accept affordable bribes.

...is clearly better, since the intereses of bribers conflict, and it this becomes in the interests of politicians to discover, publicize, and punish others bribes, even if it means putting into place systems that also limit the bribes they themselves will be able to get away with. Whereas, with all government officials having aligned incentives for identical deceit, you make unified corruption more likely.
Even with all that, your body composition would still change over time from lack of protein.
Not a terrible idea but that could be abused just as badly. I sure hope there's a way to get yourself off this list if you are falsely accused.
"Paradigm-breaking" and "kooky" are different. Pais's language is gibberish, refers to yet-unsupported effects named after himself, and betrays a lack of understanding of basic principles in the field he seeks to revolutionize.

It is overwhelmingly likely that he's simply a crackpot.
When you launch it it either reports your current setup - or replaces your current setup with the command line.

So you get everything perfect and run it - save the output to a script, and then run that script whenever the monitors decide to go weird.
Russia has been using typewriters and couriers since at least 2015.
> "Can the application be improved in any way if it were to query battery life, connection strength, metered vs unmetered bandwidth, remaining disk space?" are thoughtful questions for any developer to ask...

I suspect the answer is typically "Yes, but putting this level of thought into any other area of development would have been more worthwhile".
hopefully private repos on github are safe
Thieves and Asset Bubbles
communism

I don't think that term applies at all in this context. Somewhat simplistically, Communism is 1) A viewpoint on the historical development of society, most notably the economy 2) An extrapolation from that viewpoint on where things are headed, which is judged by communists to be a bad path 3) Advocacy for a path that diverges from #2.

There's a dozen different major branches/interpretations, but at heart they are all socio-political/economic philosophies that are far more complex than simply who owns a thing.

About the only parallel I see between free software is that both want property to be owned by the community. Though even then, I'm not sure free software would have even the restrictions that might be imposed by community ownership. (The community might say "no, don't build that thing." etc.)

Perhaps in a purely communist society software would be free, but free software itself is not inherently communist.
It's too late, I'm deeply, deeply offended. And I simply don't understand your reticence to share private health information with strangers on the internet. /s

Ok, so from what I understand, much of the fallout from a coronavirus infection in severe cases is resulting from an overreaction by the immune system. What I saw in the original paper you shared is that the most plausible mechanism would be increased propensity for isolation and mask wearing, but the IL-6 knockdown would be through CF deactivating elements of the immune system (immune signaling molecules).

The Nature paper suggests upregulation of inflammation, which seems implausible to me: "Activation of furin, which is increased in CF, together with the cellular damage induced by viroporins, might be expected to upregulate NLRP3 and cause inflammation"

The proposed mechanism in the Physio paper is as follows: "Our analysis revealed that ACE2 mRNA is elevated and TMPRSS2 mRNA is decreased in CF airway epithelial cells compared with non-CF cells. Increased ACE2 is predicted to enhance SARS-CoV-2 binding to epithelial cells but would increase conversion of ANG II, which is proinflammatory, to angiotensin-1–7, which is anti-inflammatory. Thus, increased ACE2 would reduce inflammation and lung damage due to SARS-CoV-2. Moreover, decreased TMPRSS2 would reduce SARS-CoV-2 entry into airway epithelial cells"

So, again, there isn't hard evidence that this is happening at all, but here are a couple of proposed mechanisms that could potentially explain it if it is happening.

Also I skimmed these things, so grain of salt.
I don't think that at their scale they have too much problems. I mean, "nobody" quickly will turn to "somebody" with higher prices.

They might have problems with huge monopolists like VISA. But with any competitive business, as long as they don't break the law, they'll just pay higher premiums.
What would you test with just a pure react component? What are you actually testing? Given some props it prints certain html?

I’d argue that test is not that useful. Instead what we do in the react world today is focus on integration tests. Testing what happens when you navigate to a page, click on elements, and make sure it does what it is supposed to.
Airpods Max Teardown
Yes, noted caveman technology Haskell.

In terms of dynamic languages, I’ve also worked with a great deal of Python and JavaScript, with significantly less success on large codebases (which could be due to selection bias, admittedly).
I have a very few left (like the one linked above) that I consider very precious to me. The biggest loss has been car forums for me - they still exist but the posting volume is way down
> The first problem is that the existing rules in the US are effective but prohibitively burdensome

Is this an argument to repeal the XIII Amendment in the US?