skysight-inc/HackerNews huggingface dataset:
In the spirit of clarification, I want to share snippets from three people mentioned in the Nature article [1]:

John Moult: ''' “This is a big deal,” says John Moult, a computational biologist at the University of Maryland in College Park, who co-founded CASP in 1994 to improve computational methods for accurately predicting protein structures. “In some sense the problem is solved.” '''

Andrei Lupas: ''' AlphaFold is unlikely to shutter labs, such as Brohawn’s, that use experimental methods to solve protein structures. But it could mean that lower-quality and easier-to-collect experimental data would be all that’s needed to get a good structure. Some applications, such as the evolutionary analysis of proteins, are set to flourish because the tsunami of available genomic data might now be reliably translated into structures. “This is going to empower a new generation of molecular biologists to ask more advanced questions,” says Lupas. “It’s going to require more thinking and less pipetting.” '''

Mohammed AlQuraishi: ''' “I think it’s fair to say this will be very disruptive to the protein-structure-prediction field. I suspect many will leave the field as the core problem has arguably been solved,” he says. “It’s a breakthrough of the first order, certainly one of the most significant scientific results of my lifetime.” '''

[1]: https://www.nature.com/articles/d41586-020-03348-4
I have the Paste app, with unlimited history mode. It's insane how useful it is 50 times a day.

https://pasteapp.io

(no affiliation)
> The president is not a salaried worker, it's the president.

He works. He draws a salary. What do you think the difference is?

Why can't the Vice President delegate out of hours? Because that's not realistic? Well there you go... sometimes it's not realistic.
> ook at how people criticise presidents who are golfing during a national crisis where people are dying

Isn't the job of a president to handle crisis?

The job of a doctor is not to prevent any death, just those that they can prevent during their work hours.

> What's the US got to do with it?

Because they are the champions of working non stop and yet their results when it really matters (you brought up saving lives) are worse than anybody else
Discussed at the time: https://news.ycombinator.com/item?id=4448327
This lines up with other studies I’ve seen which show that contact and fomite transmission do not significantly drive transmission (that means hand washing and surface disinfecting won’t make much difference).

Why would indoor dining be “safe”? Indoor anything is “unsafe”, as aerosolized transmission has been proven. Anything under a properly worn N95 doesn’t stop aerosols, and if anything will promote aerosols.

The idea that wearing a mask from the time you walk in the door to the time you sit down is somehow affecting outcomes is insane. People should know that walking into a restaurant carries some risk of infection and a mask isn’t going to change that.

1. https://www.acpjournals.org/doi/full/10.7326/M20-5008
NASA picks 4 companies for moon material collection outer space mining
Just because code is touched during the test process doesn’t necessarily mean it has been tested. Coverage is more useful for finding chunks of code that aren’t exercised at all by tests. Branches that never get hit that probably deserve extra scrutiny. Coverage is an interesting heuristic but 100% code coverage is not 100% bug free code.

Likewise, there’s stuff that’s just not worth it to wrap in a test. The effort involved in mocking/wrapping/abstracting sometimes isn’t worth the effort for some code, like simple calls to common libraries, reading a file, CLI help strings, etc. This stuff generally is better served by end-to-end or integration tests. Or just gets exercised naturally as part of development. Or can crash without much consequence.

My point is coverage is a tool that tells you where to look, not the one and only metric that tells you how reliable your code is.
Interesting debate; thanks for the cspan link which includes the transcript
Can you speak more to this? I've thought about using some ALPR type system to read tanker car registrations from a nearby webcam.
I feel like "requires compilation" is a good first order differentiator. And "has a somewhat sane type system" is another.
Ask HN: Functioning smart contract platform to settle HN-inspired wager?
Two HN commenters with different views about a certain event want to make a wager. Neither knows nor trusts the other. Seems like the perfect opportunity to use a "smart contract" to guarantee the eventual winner will in fact get paid. Anyone out there who can facilitate this? Thanks.
Show HN: Today – A unique experience for the current day
With the exception of the UK, none of the vaccines are officially approved yet. So the official information on potential side effects simply does not exist yet. The known side effects should be listed in the instructions once the vaccine is approved.
> The essayist even seems to take umbrage that the Dothraki armor looks nothing like Sioux buckskin! Would he take umbrage if they looked alike? You betcha he would.

Most historians, and enthusiasts of history like myself, would not take umbrage; instead, they would effuse praise for bucking stereotype and actually doing their research into how these cultures would have dressed. I'll point out that the author actually has a lot of praise for CK3 for getting its history details right.

> The truth is, GRRM's throwaway comment notwithstanding, the Dothraki serve an analogous role to ASOIF narrative as the Huns, Vikings, Kazakhs, Barbary pirates and Mongol raiders did to European history. Are you and the essayist seriously arguing that these ancient peoples are somehow demeaned by the freaking Dothraki?

I think your first sentence is unwitting justification of the second sentence. Your understanding of the aforementioned cultures [1] appears to be limited to their raiding effects on "civilized" societies, ignoring other aspects of their society as at best uninteresting and at worst nonexistent. That steppe cultures are reduced in popular history to such a degree is perhaps understandable, but if you're taking a position of trying to assert historical accuracy, perpetuating popular history myths is pretty tasteless.

[1] Although interesting that you chose to qualify only Barbary and Mongol with pirates and raiders, leaving no qualification for the Huns, Vikings, and Kazakhs. Am I to take away that you believe that the Huns, Vikings, and Kazakhs consist solely of entities predating on settled societies, and that you believe that the Berbers and Mongols had richer cultures with only a subset of these people consisting of such entities? Or should I infer that you are listing known predatory groups, and know the "Barbary pirates" only by that name and not their culture grouping (admittedly, this makes "Mongol raiders" harder to explain)?
It's about time! There is no reason a drug that is considerably less harmful than alcohol should be criminalized to such a high degree.
https://blog.doist.com/feynman-technique/

basically go back and forth between trying to ELI5 the thing, and reading source material.
Yep, before the Paypal mafia, there was the Oracle mafia :)
I have been a user since the beginning and I am probably in the minority here, but I really like the new reddit.com.

The old reddit is simply too ugly for me. They just have to make the site loads much faster to improve the UX, and make sure ads load last.
I mean, they could have just been upfront and said

"We feel that at ultimatum is not an effective way to discuss this issue and so we are hereby terminating your employment effective today."

No need for this passive-aggressive "respect your decision" [but didn't actually respectfully let you confirm your decision] bullshit.
The aspect of this story that fascinates me is that one could argue that DeepMind has not, in fact, solved anything. An inscrutable, black-box ML model has. While such an algorithm could ideally predict protein folding in any case, it can't explain anything about why, and therefore can't really advance the science.

An analogy might be that if you trained an AI model on billiard balls, it could become really good at telling you where a ball will end up when you hit it, but it could never tell you that the reason is that f=m*a, meaning it will do nothing to advance the science.
Unlikely to pass in the Senate due to many Congressional reps who don't believe in decriminalization. Has a chance depending on the Georgia runoff results in January. Would still be helpful to come up for a Senate vote to know who you're up against. Still progress to have the vote and pass in the House.

https://www.usatoday.com/story/news/politics/2020/12/04/lega...

https://www.npr.org/2020/12/04/942949288/house-approves-decr...
BC Transit’s Ransomware Attack
I was on vacation in Norway, driving from Oslo to Bergen, when I happened to take the Vallavik Tunnel and came across a roundabout in a tunnel for the first time in my life. The length of some of the Norwegian tunnels is mind-boggling enough (the Lærdal Tunnel is 24km/15 miles long!), but coming across a dramatically-lit roundabout in a tunnel made me feel like I was in Mario Kart or something, not the real world.
Thanks for this. I clicked on this thread thinking "why should I care about how den zhadanov reads books? what has he accomplished exactly?" and confirmed my suspicious when I saw the picture of him reading one of those junk business self help books. Snake oil.

This person, however, seems worthy of consideration.
It makes sense. Just as the iPhone 12 Pro is not for "professional" photography.
> SMH y'all IT people need a union.

Or just some balls. Don’t work more than you want to - either your employer will deal with it or you go find a new job. Not a big deal.

I work fewer hours than the median person at my company and I don’t think it has negatively impacted me much or at all. Any time someone tries to get me to do something that would require working additional hours I just say no or take extra vacation days in lieu (eg if I need to do something for a few hours on Saturday - I take an extra vacation day to make up. If it’s not worth it for the company, it doesn’t really need to get done on sat). Literally the worst case is you get fired, but probably nothing will happen.
If you do this in your application code, you can just store it as a 64 bit integer in postgres and optimize your index significantly, instead of using a varchar as the backing data type. These ids pack just right into 64 bits.
what about NBA players?
But Europe suffered raids not from someone like Dothraki. When you are forcing them on real history, you kind of prove there is harm.

The raids were real, but groups who performed them were behaving differently then Dothraki. They wore different cloth. They had different military tactic (notably smarter more coordinated one). They were actually organized and had much more complex internal culture.

They did raids, but were not Dotgraki. Had people did not claimed Dothraki are like those who did raids in reality, there would be no harm.
what about efcore does it work in f#? or is it bad practice to use mutable code/objects in f#?
i do not want to go back to plain sql...
> By definition, the highest voted answers are also the least controversial

That's not correct because it leaves out motivation to vote. Imagine a controversial question where, say, 1/3 of the population feels super strongly and is likeliest to vote on it. Their view will shoot to the top. Then the other 2/3 will go "wtf is wrong with this community".
> If Boom manages to ship an airliner at all, international airlines will have to buy it.

That isn't obvious considering the concorde failed.
Class files contain compiled bytecode, not source code like shell scripts do. “Script” implies human-readable source code. Java bytecode is binary, a kind of portable machine language.
What examples can you remember?
There is at least one viable alternative for some second-hand fabrics, insulation. I wouldn't use fabric insulation for all applications, but its noise dampening properties make it well suited for interior wall use.
I mean... if we took this version of the narrative at face value, I guess we'd all have been better off with no Compaq and hence no commodity PC clones.
True, however it makes sense if you look at the figure they provide, which shows airflow and infections:

https://jkms.org/ViewImage.php?Type=F&aid=694440&id=F3&afn=6...

If it were contact based, this would mean that at least one other in the restaurant must have contracted it that was outside of the airflow path. Since this not the case, the most likely thing is that transmission was with the airflow.

Why is it that you are so certain about this being surface based transmission?
A lot of charity in other countries can have the effect of undermining local institutions and make the receivers off worse.
In practice it doesn't matter. What Deep Mind has done far outstrips previous results. Now that we know neural networks for protein predictions is not a dead end, the accuracy will easily improve with time.
Seems like the difficult part would be for the contract to determine a definitive outcome. Is the wager a true/false Boolean? Can you get the answer from some 3rd party API?
ads vandalize property by causing unwanted images to appear on and unwanted sounds to emit from personal property
You shouldn't get severance packages if you're fired for egregious misbehavior. Google has admitted it was a mistake and will not be paying out severance packages in these situations going forward.
Yes, that's right, and those of us that don't have to deal with these dreadful systems are better off :-)
How to create 1305 tests targeting Gitlab in 5 minutes
20/20: Java applets needed better integration, access to the host browser's runtime. Like accessing the current page's DOM, being able to hook the event loop.

I didn't care at the time. I hated all things HTML, CSS, JS. Such a downgrade from state of the art. I regarded the browser as terrible means to deliver, bootstrap applets. Just like Flash.

One thing I didn't appreciate at the time was the genius of HTTP and URLs.

I'm still completely baffled by the "worse is better" thesis. I just can't understand why JavaScript was created, much less why it succeeded.

One can understand how mistakes like \0 terminated strings and SQL's NULL happen, become hard to undo. But JavaScript is the original sin that just keeps poisoning. Other platforms, ecosystems learn and grow and mature. JavaScript stubbornly refuses to acknowledge truth and goodness, and is all the more successful for it's belligerence.

Amazing.
> Indeed, it seems like this exact expansion of Yann's "domain" is what she is frustrated by, and you are playing exactly into it.

Your description above sounds like gatekeeping to me - not saying that is the researcher’s intent - but it doesn’t seem to make for good science
We are punctuating the transcripts, trying to make it readable. But yes, it isn't too much different.

I want to add timestamps to the video. I got some ideas from this thread.
2020 – The Year for Neobanking in India
I've been trying to use the redesign several times, and still haven't figured out how to perform a search in the current subreddit. In old reddit there's just a checkbox for that.
I'm coding on a 17 inch, 4K display laptop for work. It's not necessary but it's really nice since I can shrink the font size and fit more code on one screen while it still stays legible.
Maybe you should read Andrew Grove's book. Intel used to be this way and I suspect they just intentionally made the easy choice, not the socially/business good choice.
Of course, there's murky things like Python which make bytecode compiled forms behind the scene.

But there's a lot of magic involved in transforming Java to class files, and then there's a lot of further magic in resolving, loading, and eventually executing classes.
I share these quotes because people don't have the same ideas about what "solving" protein folding means. I'd suggest finding clearer concepts. For example:

* What degree of accuracy is attainable via each technique?

* How much (a) wall clock time / (b) overall compute resources are required for each technique?

* What use case(s) fit best with each technique?

I offer these because I see a lot of energy expended in people digging in and defending their definitions, rather than understanding what other people mean.
Depends on rare errors. I meanthings like 'My database crashed halfway a transaction, my file system drops from under my application, my back end service gave up.

You can't do much here. Dump some info, abrt the half- done work, maybe try again somewhere in the future. And yes, that last part migh deserve a test.
Abstractions and use of them is the core of our discipline, not sure why you think your comment is sarcastic.
Hey, I will look into adding these. Thanks for the suggestion.
Can you elaborate on the fixed-width fonts point?
I come from New Zealand and European trains seemed very reasonable. This possible says more about the state of NZ railways.

Even with the charges, given that you have to commute to and from the airport, that cost is basically removed with trains.
iPhone 12 unexpectedly dropping LTE and 5G service for some users
In America they definitely do that, especially the less responsibilities the employee has. That's why Netflix or Goldman Sachs can give unlimited time off and its rarely abused. But if Walmart did it, their employees would take off 5 times a month for fake illnesses.

I worked as a unionized grocery clerk and essentially everyone used all their sick time. People (including me) would call off just because they wanted to go to a party or something.

Some places try to avoid this by requiring a doctors note. But that's worse. I worked for a midsize electronics company that had unlimited sick time, but I needed a doctors note for anytime. I literally ralphed in the bathroom mid-day on a friday and HR made me go to the doctor on Monday to justify it, even though I was already better.

That policy is crazy because it creates a transaction cost for sick days. If I have a bad cold or stomach virus, might as well go into work than go to the doctor right?
Optimizing the Hiring Pipeline
Shouldn't the next step just be predicting a distribution of possible structures, instead of just the most likely? That doesn't seem crazy given where we're at on the machine learning side; predicting distributions is almost the default at this point, in many areas.
Alpine.js is worth a look as well [1]. I've been working with it as part of the newly christened "PETAL stack" [2] of Phoenix, Elixir, Tailwind, Alpine.js, and LiveView.

[1] https://css-tricks.com/alpine-js-the-javascript-framework-th...

[2] https://thinkingelixir.com/podcast-episodes/021-tailwind-css...
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> during the peak of the civil rights movement.

Actually, you're right, but you're making the opposite point than you think you are. I wasn't alive in 50's or the 60's (and I was too young to even remember the 70's), so my whole life I just took for granted that what the history books had to say about racial inequalities at those times was true. It's hard to miss, though, that people are saying the exact same things today when I can look around and observe that they aren't true and haven't been at any point in my lifetime. It doesn't make me question my perspective on the world as it is today, it makes me wonder how true the history books reflected reality at that time.
I mean, you can just install RES...

What reddit should have done is to ship the RES UI with the old reddit interface.
Seriously... like, do they want to consider open up some of the support for that UI to external contributions?
Well, its obvious, though not in the sense the author intended: its not like there are airliner retail stores to which airliners are shipped in hopes that someone will walk-in and buy them. Airliners are shipped -- and built --- in response to firm orders; if no one buys them, nothing is shipped.

But its quite possible that they could get something certified and theoretically sellable but not have something that the economics make any sense for airlines to actually purchase, much less such a clear case that international airlines are generally compelled to do so.
Yeah a bit too much hype around ML.

I was in my org conference and the guy that head AI team was stating how Deep Learning going to change the world. That it'll write software in a few years (he's from the applied math field). He also glossed over many on going problems with Deep Learning.

We're in healthcare industry and this guy is pushing Theranos like level of snake oil.

The people that don't know a lick about ML or Statistic or both rely on these people. The doctors are relying on that dude and I for these inputs. And the dude is selling theranos like stuff. I think the problem is the medical field, cs, and stat are all high level field, requiring years of training to acquire mastery and knowledge. So it's rare that someone would have all three to be able to have a impartial view or a good overview of pros and cons.
Wait wait wait!

So this is actually possible?

https://youtu.be/sfM7_JLk-84?t=120
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Our offices are located in Montreal Old Port, Nantes and Munich, though this position is open in Montreal. The magicplan Montreal office is also home to our research and development team which provides a thriving environment for work creativity and team efforts.
Please apply via our website, I encourage you to mention that you saw the post via Catherine on Hacker News.
https://www.magicplan.app
As far as I’ve seen thriftstores and vintage boutiques are actually thriving. My naive theory is that clothes are designed to break faster and faster and some older clothes have a quality you can’t find anymore, hence vintage has an aura of good quality old stuff. The other end of the theory is that the increasing povery forced people to rummage through thriftstores.
Microsoft's old "core fonts for the web" are still widely in use. (including here on HN.)
In the distant past, old clothes used to be gathered and turned into rag paper [1]. It's a shame that we use so many synthetics now as that probably drastically reduces the re-usability.

Perhaps we could add the funguses that decompose plastics into the mix and create a full-circle clothing-to-paper or fabric process.

[1] https://en.wikipedia.org/wiki/Rag-and-bone_man