skysight-inc/HackerNews huggingface dataset:
A large part of the issue with understanding the risks of mRNA vaccines is that they have literally never been done before.

On the other hand, some of the potential risks can be partially analyzed in terms of general principles.

mRNA vaccines consist of messenger RNA combined with some form of carrier (vector) to allow it to enter cells (most cells do not normally let external RNA enter them).

One in a cell, the mRNA will occasionally get picked up by a ribosome and used to make the protein it specifies. For mRNA viruses, this is usually a small portion of the viral shell that is distinct enough for the body to use to target the virus (antigen).

mRNA has relative short half-lives inside cells on the order of a few minutes to a day or so. (Larger sequences appear to generally have shorter half lives.) Thus it is not considered likely that the mRNA itself will be able to have any long term negative effects, since it will fairly rapidly get broken down in the body. Once the mRNA is gone, the cells will cease producing the protein in question.

Some Predictable Risks:

1. Unwanted effects of the carrier module.

2. the mRNA directly interacts with things in an undesirable way. (Either by binding to some other important RNA causing said other RNA to not function, or by the mRNA folding itself into some functional shape that harms things).

3. The resulting protein has some undesirable interactions with the body.

4. The resulting protein could misfold in a way such that it has undesirable interactions with the body. Even here, the effects are likely short term, although there exist ways it could become a long term effect. One theoretical way that could manifest is that it triggers misfolding in some unrelated protein into a prion configuration, thereby triggering a prion disease.

5. The normal risks associated with the activation of the bodies immune system. These are pretty much all possible with any vaccine, but specific attributes of a specific vaccine could make certain immune system risks more or less likely.

6. Other typical risks like contaminants in the vaccine.

All told, I personally suspect that in general the risks from mRNA vaccines will be lower than live or deactivated virus vaccines, including the adenovirus vaccine approach of putting the +ssRNA for the antigen in an unrelated virus that has been made unable to replicate. But obviously the risks of any specific vaccine can vary versus other vaccines of the same basic type.
Even though public opinion has largely shifted on the Drug War and marijuana specifically, there remains a problem of vested economic interests in preserving the status quo: pharma and alcohol producers that don't want competition, private prisons and prison guard unions that fear loss of revenue, etc.

Having watched legalization play out here in Colorado (quite successfully by any metric), I think what greased the wheels of viability was simple profit motive, for better or worse. The "anti" lobbyists guarding their turf were balanced by "pro" lobbyists who perceived a growth market and investment opportunity; and both citizens and representatives were assuaged by the prospect of significant tax revenue for schools. Paradoxically, it may be that full federal legalization (with a revenue-positive regulatory framework) is more politically viable than decriminalization, even if the latter objectively saves taxpayers money.
> for example in NLP, many people assume a high log prob score means a high confidence but it is not true at all

Thank you for the clarification. I wasn't aware of this, as I'm most familiar with super-basic/old NLP techniques like BOW/RNN/LSTM/GRU techniques, where log prob scores seemed to me to be roughly correlated with result quality. I'm aware the landscape has changed recently with insights about high dimensional searches...
Yeah, I'm not entirely sure what family values means aside from the name. Mostly I think it's a euphemism policies that support straight married couples with kids.

It seems to be more about small tax breaks, and making life as difficult as possible for people who are not married and straight. Actually helping people might be construed as socialism.
Great point, you're right
Familial wealth disperses and collapses pretty quickly, eventually being split up between 2 to the n heirs thereabouts.

Irrespective, the wealth is the property of an individual who earned that wealth through voluntary exchange. If they want to give it all to their kids, to a charitable cause, or just destroy it, that should be their right as owners of that property, it is not just for the state to steal that property because some people don't like it when the parent decides to give that wealth to the child. Focus taxation on things that harm an unwilling third party, not things that involve only two consenting parties where nobody is made worse off.
I’m not here to make a point. Just ask a question to hear other’s thoughts.
More. They're the majority-of-the-majority, which is a minority, but enough to stop all legislation. The system of checks and balances is designed so that any change requires overwhelming support, and even a fairly small opposition can block anything from happening.

The votes of people in favor of the status quo always count more than the votes to change, by a factor of perhaps 3 (since they need to be only 26% in order to be the majority-of-the-majority). More, really, since they need to control only one of the House, the Senate, and the Presidency.
> The fact that this won't sail through congress in a week (it'll never even come up for a vote in the senate) really illustrates how out of touch legislators are with voters.

There is a single person blocking this vote. I'd say it's rather unfair to characterize legislators in general as being out of touch when 228 members of Congress voted in favor of the bill. If fact, if you include both chambers of Congress, more legislators likely support this bill than don't.

If you want to blame more than one person, blame the Senators that elected the current Senate majority leader.
I find all your reasons are either fluff, or just saying that small businesses are good for their owners. Economic efficiency is net positive, and people who aren’t small business owners benefit a lot from online, efficient shopping. If some segment of society needs charity, they need to convince either the gov or nonprofits to give them some money, not rent-seek on other people.
And the 24 Core 128G RAM machines are how we get bloated software...

(not blaming anyone in particular)
The only useful thing to me is to append "Reddit" to some Google searches for certain niches. occasionally it brings up a post describing exactly what I'm looking for. It's always an old post though unless I'm searching for the latest in the US Democratic party's talking points, then I can just go to Reddit.
Previous threads on this ongoing story:

https://news.ycombinator.com/item?id=25292386

https://news.ycombinator.com/item?id=25285502

https://news.ycombinator.com/item?id=25289445
So let me, please, pay zero taxes, during the strikes. Or the minimum that doesn't go to those who are striking. It's a public service, like medicine... What if one has an appointment to an oncologist at 11AM, outside of "service minimum" hours. It's so irresponsible!
Is there evidence though that asymptomatic Case C didn't leave before A and B arrived and gave it to both via a surface?
Wrapped and Sold – Liz Pelly
> It's not easy to downgrade machine performance tho.

yes > /dev/null &

Repeat until slow ;)
The new turbolinks they use on hey.com is using a concept named „portals“ so different parts of the web application can be refreshed independently. My linked inside hey.com articles are very interesting.
> fully legalizing now would violate a number of important treaties with other countries

As I understand it, the US Congress has the power to withdraw from any treaty with legislation without restriction[0], by passing an Act that repeals the effect of the treaty. "Parliament | Congress cannot bind its future self" is a well-settled Common Law principle.

Treaties receive no special status. While they may be negotiated and recommended by the President, and come into effect upon supermajority consent of the Senate, treaties are nevertheless held to be legislative in nature. Since Congress cannot bind its future self, it can repeal any treaty at any time with the usual mechanisms.

Meaning: an Act that fully legalised marijuana could include clauses repealing the legal status of treaties.

Of course, I am not a lawyer.

[0] https://en.wikipedia.org/wiki/Head_Money_Cases
Why is this a problem that needs solving? If the user chooses an ineffective word they'll figure it out pretty quickly... and if they choose an offensive one-- that's on them.

They could also walk around saying offensive words when not addressing the computer.

Or is google planning on 'fixing' that too?

:)
r/news used to have a r/The_Donald mod, and as a result, r/news would remove news articles that could make conservatives look bad even if they fit within r/news' posting guidelines.

Around the time of Cesar Sayoc's, the "MAGABomber"[1], mail bomb campaign, even Wikipedia articles like "Terrorism in the United States"[2] were banned in comments, and posts that contained it would have the AutoModerator shadowban the comment instantly.

[1] https://en.wikipedia.org/wiki/MAGA_Bomber

[2] https://en.wikipedia.org/wiki/Terrorism_in_the_United_States
Why not The Spectator? I think it's a good read which frequently has thought-provoking articles. This is despite me disagreeing with a lot (maybe even a majority) of their writers.
"And I get it, they have to deal with a lot of people, all with their own opinions, many of which are indeed wrong."

This is a great point, but it's important to keep in mind that many medical professionals INSIST that you get your healthcare from them.

If you're going to force people to obtain their healthcare through the system you run, then you are obligated to address all their concerns.

But this is impossible. That is why medical freedom is so important. Medical freedom as in the ability to choose your own insurance, decline medical treatments, or pay out of pocket for whatever test or treatment you desire.
Until now, nobody on my previous team at Google had to have their papers reviewed internally for scientific rigour either.

(We have a publication approval process, but its purpose is to prevent IP leaks and maybe shield liability, not uphold scientific rigour standards)
That's not quite true. They just renewed the 2016 platform. Their resolution states "without adopting a new platform" and then attaches the full 2016 one below it.
> what is an example of a good

Good for you is the one you enjoy using. Good for me is the one I enjoy using. Even if I didn't have a problem with Solarized's lower contrast, I would still think that its colors are hideous.

The problem for many with low-contrast themes is that they often aren't focusing on keeping contrast high. They're mostly focused on keeping contrast low. They aim to avoid being "too contrasty" without targeting being "goodly contrasty".

> color blindness?

Color blindness is its own set of problems. To the best of my knowledge I'm not colorblind. I just can't easily read poorly differentiated text unless I really crank up my screen's brightness or make the text much larger. The problem I think is mostly one of pupil physics relating to the impact of external light on pupil dilation and how that affects both focus accuracy (pinhole cameras focus perfectly without lenses) and also the amount of light entering the eye (smaller aperture means less total light, less light means less difference between light things and and dark things). Neural color perception is another issue that is related but only sort of. Or maybe there's an analog to colorblindness that we just don't talk about that deals with sensitivity to luminosity variations. IDK.
Are the men treated any better?

It's OK not to like something, but you embarassing yourself by disparagingky dismissing it. One could also say that Tolkien is racist with tediously florid prose.
Is your stance that wealth in the hands of billionaires tends to do less good to raise the “common good” than if it were to be distributed in some way?

If so, what kind of distribution do you think makes sense?
It sadden me that they make Jeff Dean work on these kind of issues. His map/reduce invention brought to the world a lot more than managing his coworker egos.
The Experimental Engine That Could Get Us Anywhere in the World in 2 Hours
So what should happen to your assets when the total of their market capitalization crosses the $1B line?
In America, at least, we have historically rejected the idea of a hereditary monarchy.

Literally nobody is suggesting that the children of the wealthy should be penniless.
The difference in information density really isn't that large. Here's a comparison of the current top posts (and not even using the compact view): https://imgur.com/a/WsI3pBj
"Exploit what people want"
What was your first language? Mine was Basic.

Pascal was the first language I was taught in.

I still have not (after 40 years) learnt Python... Hang on, when did Python start....That long
Who would allocate resources better?
That's a clever turn of a phrase, but doesn't justify your position in any meaningful way.

Can you tell me why it makes sense for so few people to dominate the wills of so many?
Yea that's reasonable, but there are pros and cons and it's also definitely an opinion :).

I don't see the problem with piping help text through a pager (that's literally all `man` is doing). Alternatively, a tool can use a pager automatically (as `git help ...` does). So `man` isn't required to have a pager. Whether you should use a pager by default is a different argument.

That said, I find pagers annoying because it's hard to switch back and forth between typing a command and the docs. That's way easier to do with scrollback. Although someone in this comment thread also mentioned the `PAGER` env var, and that you can set `PAGER=cat`, which is a good pro-tip. So, TIL.

Still, if you're concerned with command-line ergonomics for a broad audience I think there are more people that either 1) know how to `| less` or 2) prefer or don't care about a pager than people who are gonna automatically just know they can do `PAGER=cat man <some-subcommand-of-my-cli-tool>`.

Plus, there's still the cross-platform argument.

Oh, and OP doesn't mention this, but man pages also complicate install, uninstall, versioning, and having multiple versions of a tool installed simultaneously. Built-in help is obviously just works and is distributed with the standalone binary. To use man pages you have to place additional artifacts on the system and make sure they're managed correctly (e.g., versioned). It's additional complexity with basically zero benefit.

So yea. Seems like, as a rule, their guidance is reasonable. I don't see a lot of benefit to using man pages other than "because that's how it's always been done".
Watch Live Marseille vs. Nimes
The point of FizzBuzz is to see if the person understands the basic concepts of a loop and "if" tests. You're supposed to give them the modulo operator to ensure you're testing the right thing.
I haven't quite done it yet, for different reasons, but I've done a lot of research and debating jumping in the next year or so. You mention "finishing" your degree, which I assume means you have at least some credit completed. You do have an advantage there as there a a number of programs specifically for that. Doing it from scratch might be a bit more difficult, but if you have enough money saved its probably still possible. Are you looking at online programs or to go back full time to a brick and mortar? I imagine depending on how much money you make, you wont get much in the way of aid, but if you have the money not to care and just want to cross it off the list, I imagine its possible. There are additional complications depending on your certain situation, but given you description, I would assume many are inapplicable to you.
Name them. The reason weed will not be legalized in America with this bill is solely, and only, the fault of Republicans
Instamatic – Automated marketing tool to scale Instagram dreams
Not all keyboards are the same...

!@#$%^&*()_+}
We also don't know what the adverse reactions to this one are likely to be. mRNA vaccines are very new, and they've never been approved for human use before. If there are long-term adverse side effects, we don't know what they are.

> Given the novel nature of the mechanism of action of RNA vaccines, and their drug delivery vehicles, little is known about the medium and longer-term side effects.

> Up until December 2020, no mRNA vaccine, drug, or technology platform, had ever been approved for use in humans, and before 2020, mRNA was only considered a theoretical or experimental candidate for use in humans.

https://en.wikipedia.org/wiki/RNA_vaccines
Big companies make seem more into making inflexible processes and eliminating the variability of trust.

The people who do follow the rules are left feeling shorted by those that don't. That doesn't seem right.

I think this happens with a lot of things. The employer can say "be trustworthy" and save money across the entire pool of employees, but the employees who follow the rules have to stand by watching other who break them.

Same thing happened with marking spots in my apartment complex. They numbered the spots to go with apartments, but don't enforce it. Someone always takes my spot. According to their rules I'm supposed to park further away in the unmarked spots, or steal someone elses spot. Most people follow the rules, so the office gets less parking complaints. But now people whose spots are taken are left worse off than before.
How many people need to be vaccinated for life to go back to normal?
>Can you imagine a better way to destroy social mobility than by telling poor kids that the way to get rich is by exploiting people, while the rich kids know, from having watched the preceding generation do it, how it's really done?

I'm so glad someone finally said this, I wasn't sure if I was the only one with the same theory about inequality and it is articulated well here. It's "cultural inequality", inequality of cultural capital.
I wonder how consistently these standards are applied, even zeroing in on Google. If it turns out that most people within the company don’t face a barrier from this process in the same way then that sounds like a really problematic symptom.
In aggregate, the 400 richest billionaires put together only constitutes 4% of the total wealth in America.[1][2]

Even if you assume that power correlates perfectly with wealth, there's not really evidence that billionaires control anywhere near enough money to become a "permanent ruling class".

[1]https://www.brookings.edu/blog/up-front/2019/06/25/six-facts...
[2]https://en.wikipedia.org/wiki/List_of_Americans_by_net_worth
“Boundary layer theory” was the tongue-and-cheek way my undergraduate professor would hand-waivingly dismiss hard empirical problems that couldn’t be rectified with theory
I'm not convinced on this.

Both Vim & Emacs have hardcore followings and buoyant communities.

Neovim + coc.nvim is massive these days... I know a lot of people who've moved from VSCode (or other big IDEs) over to terminal-based editors...
They are not followed in the first place and it's a problem. Drivers who work for 16+ hours per day cause road accidents. But those regulations are a good thing, same as for aircraft pilots.
No, the Republican platform is for a giant central state but all the resources to be used only for military and police. (Though the policing is only for common people, policing of corporations or rich people is to be defunded and labeled as evil regulation. )
Could it be that attempts to improve them were reverted?
pgs pg
My mind's been picking at related ideas from different angles for at least a decade now, I guess.

I'm not sure how I feel about this one, but one thing I like about separation approaches in general is that it's easy to imagine how N different annotations can all exist for the same underlying document, so you could use something along these lines to share/exchange/discover/crowd-source annotations.

That said, my general yearning isn't to kick all markup out of my documents--but to kick presentational markup out. Semantic markup can add a lot of affordances to your documents, and if I'm already committing to working with something that requires a toolchain--I suspect I'd rather just generate plaintext or presentational markups from there?
Why I Don't Retweet Anything
COVID19 support just means stealing from taxpayers to line the pockets of the rich. As more information comes out, the scam will be more revealed but unfortunately we do not live in a country of educated voters.

I don't care about COVID relief. If anything passes it will be a scam and no money for the taxpayers who fund it.

https://www.washingtonpost.com/business/2020/12/01/ppp-sba-d...

https://www.independent.co.uk/news/world/americas/us-politic...

They are literally and blatantly robbing our country at this point, but the political institutions are too dysfunctional to do anything about it.
Apparently C# 7 can match discriminated unions quite well[1], with the caveats being:

1. you need a dummy type[2] for empty parts of the union.

2. it still can't enforce exhaustive matching.

[1]: https://stu.dev/pattern-matching-fsharp-union-types-in-cshar...

[2]: Maybe () would work?
"Have them made into a quilt"

Usually this means getting them all together, calling around to find how much it costs to actually make a quilt, then putting them back in storage.

Takes a lot more time and effort to make a quilt than people think.
Zettelkasten for Indie Devs and Product Managers
Are you just clinging to the last dev version of uMatrix, or did you find an active fork or something?
> I'd believe that it is, but why would they publicize that they've unlocked "the secret to quieter drones" if that were a classified development?

Marketing. For a potential adversary to gain useful knowledge from this article, they'd need some numbers to understand the extent of the capability. They're not learning much from "we're using computers to make shit better", they already know that.

It is not uncommon for the military to publicly announce something, yet keep the specs a closely guarded secret.
Modern particle-board (cheap material houses) provide significantly less time to get out in case of a fire than much older, sturdier wood construction however.

"Research shows that 30 years ago, you had about 17 minutes to escape a house fire.

Today it's down to three or four minutes. The reason: Newer homes and the furniture inside them actually burn faster."

https://www.today.com/home/newer-homes-furniture-burn-faster...
Two bodies have simple, non-chaotic solutions.

Three+ bodies do not solve linearly. Thus reveal themselves as unsolvable probabilities and pattern structures across scales.

The individuals and environment exists co-dependently.
This essay uses a weak straw-man: the only way to become a billionaire is by exploiting people

I think the "principle of charity" or "steel-man" criticism of billionaires isn't that every single billionaire is directly exploiting people. It would be closer to something like this:

The problem is that our society has feedback loops that make it hard to escape poverty, and feedback loops that let the wealthy amass more wealth and power. It doesn't have to be this way, it's a product of our laws and can be changed.

Warren Buffet doesn't directly exploit anyone. However he does pay less taxes than his secretary. To the extent that Uber drivers and Amazon warehouse workers are exploited, it's because our society has millions of desperate people struggling to get by. What's the point of being the wealthiest nation ever on paper, if there's terrible schools, high infant mortality, and lead in the drinking pipes?