skysight-inc/HackerNews huggingface dataset:
They are two topics which are both relevant to the discussion.

Structure determination is what allows you to see the purpose/effect of the sequence that the DNA encoded.
I'd say 17% of the computer market is sizable but still small and segmented enough to be premium. Macs don't factor into the purchasing decisions of the vast majority of ordinary people.
Yeah it because the Erlang VM have a preemptive scheduler and each process have a mailbox which gets a designated amount of time to access cpu.

You can do a for(1) for loop and it won't hog the cpu because it get premptive. The problem is when you have large amount of problematic mails in the mailbox....
Easy for everyone to point out that its unhealthy to be money focused. But that's missing the point. The author is clearly aware of this problem. The question is how to get out of this cycle..
FWIW, I have experienced all those things with different Android versions, and mainline K9.
That letter Slack wrote to Microsoft after they rejected a $$$ takeover a few years ago has not aged that well.

https://slack.com/intl/en-gb/blog/news/dear-microsoft
Although Gibson's Sprawl stories and novels are probably better known, this is actually my favorite Gibson short.
The mistake isn't permanent, the IRS can still at least attempt to collect back money sent in error. Money doesn't vanish forever just because it went into someone's bank account.
Yess! Exactly what I'm looking for!
That's really neat. Once your model is complete, does it work offline?
Unable to process command - got response: {"message":"Internal Server Error"}

Heh. \ is not a valid entry.
Perhaps we'll live to see The Diamond Age
Android fork cannot intercept request between (for example) Slack backend servers and Google backend servers.

To fork this service, you need your own push notification infrastructure and then persuade app developers to implement it as another option (next to Apple, Google, Firefox, Huawei and other existing ones).

There are push arbitrator services which make this easier, so perhaps having those on board might be a good path forward.
Yes but that would be the recipe for their new and improved soggy fries.
> This is just phrenology ...

It's probably worse. I'd bet that in addition to humans with non-'normal' heads, it would also flag the blind, deaf, sufferers of Tourette syndrome, certain muslim women, bearded men, humans of african descent, humans of asian descent, etc.

> even if the calipers[1] are replaced with a bunch of linear algebra.

I love this line. If your head does not fit the space of eigen-heads, throw an error.
They have published the spec and released the patents to Open Invention Network though. IIRC Samsung provided the actual implementation that is in linux 5.4+.
While division is a problem, you could symbolically represent numbers such as 1/3 by storing the numerator and denominator as a fraction of 2 values.
Yeah, agreed.

My selfish concern is then whether or not the vaccine will work for them.
Wait, you thought of all places on the internet, hackernews would forget about your posts? :-D
That's probably part of it, but there's also some history.

The southern US used to produce a lot of sugar. Before refrigeration it was heavily used as a preservative.

So there's a big market that expects things to have a lot of sugar in them.
Ha! The technology itself is cheap, fabricating a bunch of de novo mRNA is only a few hundred dollars these days. I’m not sure how much volume is needed for treatment, and there’s obviously much stricter QA/QC that must happen for human use, but still the actual manufacturing part is likely no more than single digit thousands per dose. At scale, per your semiconductor analogy, could likely be brought down to single-digit dollars with time.
That is an impressive improvement, but I think you've missed the most important point:

>a score of around 90 GDT is informally considered to be competitive with results obtained from experimental methods

So DeepMind is to the point where it's a question of whether their generated model or the experimentally determined structure is closest to the actual physical structure.
With empathy comes many gifts, well-being, and a culture that is more sustainable.
The set of all proteins which can potentially be expressed in an organism is known. Now maybe we also get decent (static) structure information for these. But the interaction of a virus with the host cell is much more complex. There is much more than just an amino acid sequence involved. And these parts are all moving, so a static picture as we now can create faster than before does not contain all the information necessary to fully understand the functions.
Our Nissan Leaf has a 12 volt lead-acid battery. I guess that was easier than bleeding 12 VDC off the traction battery to run the radio.
Introducing “GCP Project Switcher” Extension for VSCode – My Weekend Project
Yay! I already got tired of typing --use-feature=2020-resolver.

With this, it's a lot easier to upgrade everything without getting conflicts: pip freeze | cut -d= -f1 | xargs pip install --upgrade.
Yes, I just did last night (to install youTube-dl in fact).

You do have to specify Terminal to launch using Rosetta however.
We do? I don't know who the OP had in mind at all.
It does. https://www.nature.com/articles/d41586-020-03348-4 reports a case of x-ray crystallography helped by AlphaFold prediction.
The emulator has to handle and the testing infrastructure has to have tests for each subregister and how it affects its parent register. You have to prevent and detect design-level oversights such as "AH is not the LSB of AX/EAX/RAX and my design only accounts for LS-whatever subregisters". Your point that they can't be distinct holds, but but if they were distinct they would have less impact on the engineering than they will have as subregisters.
It's mostly because the feds have been lightening up on forbidding the research and in granting permission to do it. See also state governments as more evidence comes to light that they just might help (significantly) various neurological issues, particularly depression and anxiety.
Nah, the public charge rule refers to a specific set of federal benefits. This legislatively created extra tax refund is not one of those.
> (that's the third time in this thread that you've thrown the "FUD" accusation, just saying)

Yes, you are right. The reason is the wrong claims written in a convincing tone and (intentionally?) ignoring facts.

For example, here you ignore that this company is providing much more than any other company typically provides (schematics). Purism also promise manufacturing files and have a history of fulfilling their promises (even though sometimes with delays). I have no idea how you can say "resounding no" if you take into account the alternatives.
Yeah, agreed.

I didn't want to get into a whole explanation for someone, just to make a point about density not being the primary driver in this case (although it definitely has an impact).
There is a good article here but unfortunately paywalled https://www.wsj.com/articles/moderna-and-pfizer-are-reinvent...
FCC Chief Ajit Pai, Who Ended Net Neutrality Says He’ll Quit Jan. 20
As someone who wrote a thesis many moons ago about protein folding, this is pretty astonishing to see. Yay science.
Yeah, that's the thing that would worry me the most: it's nice and all that I can use many regular Android apps, but how do I know that that's safe? In practice, I'd probably still restrict myself to F-Droid, like I do today - the only app I'd like to use in addition is our Corona warn app.
There seems to be a bug on mobile safari for iPhone. I can’t type more than one word so can’t progress past the grep command on 2
Using Cloud Workflows to Load Cloud Storage Files into BigQuery
Scientists can verify that an AlphaFold-predicted structure is correct, or at least useful, without being able to get the structure experimentally. For instance, we could use the AlphaFold-predicted structure to do protein-ligand binding calculations for a bunch of known molecules. If these calculations agree with experimental protein-ligand binding (which they generally do for proteins with known structures), then we can say with high confidence that we've got a good structure.
Same situation here in Sweden. Nobody would take it. We set up a Facebook group to find solutions, the easiest one being just getting a US bank account. It's really considered a stone age system here.
ADHD and ASD Medication Efficacy Algorithm. Built for myself, now expanding it
Hi everyone!

I built https://moodmap.app/ originally around the issues I had to work through when managing my ASD and ADHD. There's still a lot of work to do, I think it's pretty neat so far though.

It uses ML, NLP and gamification to help with treatment. You take care of yourself, you get a spirit animal based on your personality type computed by the app, then it gets levels and then you get paid money for having taken care of yourself (working out a funding mechanism ASAP, almost there).

In terms of how I want to manage privacy, which I think is ridiculous important in building a tool like this, I am trying to implement SOLID (https://inrupt.com/solid) as a way to make sure any data that is used is completely under the control of the people who need the tool.

Lots of bugs and things to iron out over time, trying to build everything in the open to see what people think (and because I enjoy the feedback!!!)

Love to answer any questions !

This ML algorithm is still a work in progress in terms of it having a high degree of accuracy for ritalin efficacy treatment, over the next week I should have it being incredibly accurate :D

Mike
I don't think the $1200 helped that much, A large chunk (33%) of the money was saved and another chunk invested. I think politicians and media oversold the efficacy of stimulus.
Those who do not remember the Bell System are doomed to see it repeat in varying permutations.
David Baker's lab is working on this; their Rosetta program has been getting reasonably good at it.
But it's also worth noting that the existence of the lockdown was flagged 10 days before it happened, which presumably changed behaviour by scaring a bunch of people.
I remember that, was on the front page. The writing was on the wall the moment they took out that full page ad in NYT which is a bizarre PR move that signalled fear.

Can someone pastebin the article for us?
It's probably never going to be solved though right. To truly solve protein folding we'd have to have a program that can stimulate a small but still significant system at the QM level; looks like deep learning can get us 60% (conservatively estimating the whole problem domain ) but not all the edge cases, just like it did in other problem domains as well.
I don't understand why they're making a news story out of this $34 million dollar error without mentioning that they also sent $1.7 billion to the deceased. Neither seem newsworthy to me, but only detailing the cheapest error is strange.
What'd you say aged least well about this?
When I was learning phonetics many, many years ago, I was taught that a final "e" made the preceding vowel long.

hat vs hate,

din vs dine, etc.

I suppose that convention developed later on.
FWIW: Docker will not run x86 VMs. I only mention this because you brought up running Docker via Rosetta.
Rising temperatures mean that female green sea turtles outnumber males 116 to 1
Are there serious suggestions that everyone be forced to take the vaccine? I haven’t seen that, and frankly I’m not sure that would stand up to court scrutiny.
True, true, but the money involved is so little that it's likely to result in not much regained, right? After all, the IRS doesn't usually find it worthwhile to send tax delinquency information to the state dept (which is the usual mechanism to force payment from non-resident non-citizens) for these sums.

Though if I think about it, non-residents who were legitimately paying taxes are unlikely to not return the money if asked so maybe it's worth it.
Slack fosters vibrant (free) communities in open source and academia. I fear these are not long for this world.
I watched a documentary on Vimeo that showed how magic mushrooms contributed to the evolution of our species dating back to neanderthal times. https://vimeo.com/ondemand/fantasticfungi/397318008
Remember there is the 5nm advantage.
Well when pip installs an incompatible version of Numpy relative to my current setup (without warning me) then I do indeed blame pip.

To be fair, this release makes that much better, which I am extremely grateful for.
The full chain is DNA -> mRNA -> Ribosome -> tRNA combinations -> amino acid chain -> protein.

It's true that in nature there are many steps between DNA and proteins (this list doesn't even include the steps that mediate the translation, ie. start it, stop it, slow it down, ...), but the structure of a protein is fully determined by the DNA code.

Protein folding is about you start from the DNA code that is fed into the ribosome ignoring all the meta information, and come up with an atomic model (VERY long list like "H atom at 3.27,2.17,12.18, C atom at 2.87, 2.19, 12.33, ..."). Now there's a million niceties we've discovered to make this problem simpler and nicer looking, but that's what it boils down to.
Ahh, yes, ModeRNA's vaccine is some very clever stuff.

The way that one works is a bit complex. Essentially, they still want your immune system to recognize that the virus is bad and then make antibodies against it.

Usually, you inject broken up bits of a dead virus into a person. The immune system sees the foreign objects, and makes antibodies against it.

Withe ModeRNA's vaccine, we go inside out. You have the body produce inactive parts of the virus itself. In this case, the 'spike' proteins of the viral capsid.

They do this by injecting mRNA into you. Through some complex bio-chem, the mRNA that codes for the spike protein gets into your cells and makes the ribosome complexes produce the spike protein. These then get out of the cells, again via some complex bio-chem, and the immune system sees these spike proteins. The immune system then builds antibodies to the spike proteins, just like with a regular vaccine.

Basically, you skip a few steps in the antibody creation process.

I want to stress the mRNA injection part. This method skips the DNA, meaning that you are not editing the genetic code of the cell.

The real magic here is the potential such a method has. With this method, you can have much better targeted cancer cures, much broader flu vaccines, and time limited protein production. Think time-limited genetic engineering, minus the actual gene editing. Want to glow green for a few days? No problem. Want to mitigate diseases caused by missing DNA? Just take this.

Note: This is copied from a previous comment of mine here:https://news.ycombinator.com/item?id=25047289
There's also BEAM Wisdoms: http://beam-wisdoms.clau.se/en/latest/
...oh, I just re-read the great-grandparent. I didn't realize the application's servers were talking to Google's servers, I thought the application was talking to Google's servers directly. That seems terribly convoluted, although I assume there's actually a sound reason for it.
> Third, you’ve got to do this with love. You’ll need to take a radically different approach to supporting and partnering with customers to help them adjust to new and better ways of working.

This is so cringe-inducing, I can't believe they paid to have this in the NYT. Microsoft stock up to all-time highs as Teams eats Slack's lunch (for better or worse), while Slack bought for scrap by a company way worse than MSFT. Maybe don't publicly shame potential acquirers in passive-aggressive paid advertisements?
New Playstation controller interface library for Arduino
This may indeed be a problem. Perhaps one can use webapps for some of those use cases.
yeah i saw a lot of those errors :( it calls a lexical parser on the input which doesn't like it.
> It seems to me unavoidable that human would look for sex.

Sure. But there are proper ways for it. Legal ways. There are reason why those behaviours more and more get outlawed in different countries.

If someone makes it clear they are interessted in dating, then yes, go for it.
But just to exist is not a clear hint for this. Dating is still special case of social interaction, not the default.

> > victim
> This mentality underlies a very unhealthy view of dating imo.

This has nothing to do with dating. The victims here are mainly the people who are forced to cope with that crap, but never asked for it, and don't wanna date any of those people for whatever reason.

The joke here is, we do have elaborated spamfilter and adblocker to get rid of all the annoying crap in our mailboxes and webbrowser, and most user accept it as neccessary because ads are just aweful. Yet we still don't have filters for dickpics and sexual harrasment. Quite funny, just because it's Humans doing the same, instead of business?
Isaac Asimov – The Machine That Won the War

Only because it paints such a perfect picture of the inanity of so much of the work that we do in the software engineering profession.
The context is so simple to me, I have hard time believing the other readers can miss it. The OP means party-goers etc, not teachers, doctors and such.
I don't think they are making any claims about Musk's relationship with his family- rather saying that 80 hour weeks let you succeed in two ventures- Musk pursued two companies- they are pursuing one company, and one family
The mRNA must enter a cell to express proteins. The delivery vehicle is a "lipid nano-particle", a particle that can contain a payload and attracts surfactants to protect the payload but also allow it to penetrate cell walls. They're a bit unstable, thus the need for refrigeration. The other way this can work is using a virus, which is what the Oxford vaccine does.

You can do protein vaccines, and some are coming, but they're slower to develop as you have to figure out a way to manufacture them; with a nucleic acid you can have the body do that part for you. Additionally, the mRNA produces a more complete response; some parts of the immune system react to proteins expressed on the surface of cells, which direct protein exposure doesn't do.
> If you upload a module to CPAN, you automatically get it tested against a huge matrix of configurations.

Very true, and it's definitely a great service!

However, the set of versions/configurations is still limited, and it can take an awful lot of time for the matrix to fill up. I've fixed a bug specific to perl-5.10.0 about a week ago and so far the module hasn't been picked up by that version again.

So while this is definitely good as a service for the general public, it doesn't get you very far if you're trying to build a thing that's supposed to ensure compatibility for other Perl modules across 20 years of Perl history. :)
Your point is well taken on future returns and how starting the compound interest cycle is a major contributor to success.

>that has never happened

This is the part that I disagree with. Talk with anyone who planned on retiring around 2008-ish. As a hypothetical, if the market is the proxy measure they lost around 5-8 years of retirement because they had to have "more time in the market" to re-coup losses. If they actually retired and were drawing down their money, it's even worse. Granted, the hypothetical is biased because someone of retirement age shouldn't have that much market exposure, but the point still stands that, while true at the population level, waiting for the market to recover doesn't always work out well at the individual level. I tend to think the people who tout long-term averages of market returns tend to ignore the long periods of sideways or downward movement that may align with an individual's specific circumstances.
> Tbh it’s kind of weird to me that Apple didn’t sponsor the work needed for this, and would ensure that it happened sooner.

It's unfortunate they don't have a package manager. They could do better than apt if they put resources behind it.
With some notable exceptions applications have become slower in a way that is just fundamentally unnecessary. Fifteen years ago you could do text editing, browsing the internet, chatting and possibly editing spreadsheets all in parallel on a machine that today would not be able to do anything with the same (but upgraded!) applications. This is not due to features that are "just more expensive" (though as said there are some notable exceptions, like probably decoding 4k video on youtube) but because the development process has migrated further and further away from any sort of performance concern as the platforms you could expect became faster.

That is not to say the computing landscape was fundamentally better fifteen years ago. I think it is almost the same. What has really improved is the general usability and stability of drivers (no more rebooting, random freezes and if you run linux your X server not working every other update), which is definitely something to be proud of. What has not improved is basically everything else and I'm really not sure why.

If I had to guess I would say it has something to do with managers the world over just not giving a shit about delivering something good, as long as it sells. As platforms have started having more headroom for bad software, "as long as it sells" has started to have a wider and wider performance profile. Landing us where we are today: with many of the same features, much less privacy and every other app packed with an entire browser "because it makes it easier to develop".

Even as recently as last year I had a more relaxed stance about this but I guess it has just been bothering me now that I have more time to think about the state of my work (and everyone else's).

Edit: I see now I responded to something slightly different than what was requested.

Modern (AAA) videogames should not be bought or played because they are produced by a sick and exploitative industry that really needs to die. Instead, we can prefer the indie games that work well with what they have: Generally a lower graphical budget that runs significantly better on hardware that is "out of date".

For office-type processing and messaging, there are generally application choices and tradeoffs that can be made for more performance instead of more eye candy. The average office worker (which I guess includes most people here) will not materially care that it doesn't look quite as good. Another upside is that as a company you don't need such an enormous budget for office hardware.
My understanding of this is not perfect, but wouldn't answering the "actually does" question require a full biomolecular model of the cell, or even the whole organism? If so I see what you mean. I suppose that it might be possible to get around this by improving the theory of catalysts so that you could look at a site and say, "oh, this will act in such a way..." Dynamic quantum simulation of a few atoms at the active site is hardly easy but a far sight easier than the other.
Exactly, daddy wolf and mommy wolf are alpha wolves. The issue is just who to assign the "alpha" term to: Alpha wolf is the top of the hierarchy, not the strongest.

This post just wants to redefine the "top" wolf, because of specifics of his knowledge: that strength is not the defining factor of alpha wolves, which is fine, but it seems to be like a grammar nazi yelling "well, actually, it's spelled xxx".

If a wolf can't keep up a fight then it is bound to be killed unless every time he gets into a fight 10 other wolves defend him, in which case he's not weak anymore: he won a numbers game, or a social game, whatever, in other words, he's strong, the because is irrelevant, but in this case it is because he probably has a family and/or is useful to other wolves.

In the end, the alpha wolf is an alpha wolf because he's resourceful. It could be a purple wolf, maybe you want to call it monkey wolf, I don't care, he is still the 'top of the hierarchy' wolf and I will simplify this to "alpha".
Yes! I only provide a higher-level library for Rust, but you can use the lower-level host functions from any WASM code if you run it on Lunatic.