skysight-inc/HackerNews huggingface dataset:
Vector Engineering, Broad Institute of MIT and Harvard | Software Engineer, Data Science, Data Viz | Full Time | Cambridge, MA | REMOTE/ON-SITE | https://vector.engineering

The vector engineering group at the Stanley Center for Psychiatric Research at the Broad Institute is a technology development laboratory focused on engineering gene delivery vehicles to address specific needs of the neuroscience community.

Viral vectors have proven incredibly useful for studying the diversity of cell types and connectivity within the nervous system. The team applies high-throughput selection and screening to engineer recombinant viruses that enable more efficient and selective gene transfer to defined cell types in the CNS. The ultimate goal of these efforts is to develop treatments for psychiatric disorders by supporting hypothesis testing in a variety of model systems.

Additionally, we are developing https://covidcg.org, a platform for analyzing mutations in emerging SARS-CoV-2 strains in a location and date-specific manner. Tracking the evolution of SARS-CoV-2 will be crucial in developing/adapting diagnostics, evaluating policy interventions through tracking the spread of specific SARS-CoV-2 isolates, and monitoring the effectiveness of vaccines/therapeutics as they are implemented over the next few years.

We are looking for a software engineer (entry-level ok) with high attention to detail and a passion for developing tools to aid with the current COVID-19 pandemic and to advance gene therapy development. This position will be adding features to the https://covidcg.org application, as well as developing internal tooling to process, analyze, and visualize sequencing data from over 100 million virus variants.

Experience with web development, React, and python data science libraries (pandas, numpy, etc) is ideal but not required. Biology experience is preferred, but not required. We are an interdisciplinary team of biologists and computational scientists, and aim to grow our trainees to find future success in the field of computational biology.

Please contact vector-engineering@broadinstitute.org with a cover letter and resume, or ask me questions directly at chena@broadinstitute.org
Twin Galaxies goes on the legal offensive against Billy Mitchell’s “fraud”
Yes, this is the right way to approach it in my opinion. Use the right tool for the job. So many people in this industry see everything as a nail and the hammer they know is all that is needed for it.
The Remarkable Similarity of Covid-19 Infection Waves Throughout the World
Boost Conversions with Behavioral Science. P2: Social Proof
Cool example of agent-based modeling applied to Covid-19 vaccine distribution
Ok I guess I was missing the basics on overcollateralization, https://www.investopedia.com/terms/o/overcollateralization.a... answers my question, it was actually not blockchain-specific.
HA! I should have mentioned that in my post where someone was asking why Intel was going downhill.

Worth reading the full thread at https://news.ycombinator.com/item?id=25187136

> I worked for Intel for a few years, 2005-2007. It's hard to put into words what happened to Intel...
What would you expect them to be doing instead? Getting a job? Taking a year off to travel?

Not saying that there aren't other valuable things they could be doing with their time, but just that other options are also constrained.
I think this is really neat. I've never really understood using Serverless platforms for websites and things that process web traffic as there's almost always enough that a "real" webserver is quicker, easier, and cheaper.

However, I've seen many things that run a couple of times a day, or in response to a deployment, or things like that, which often need some compute behind them, but for which setting up a little server and hosting it somewhere just to call it once a day feels like so much unnecessary ceremony.

Does this have a maximum function duration? If so this could still rule out this approach.
The cost of being down might be high and happens seldom enough that hiring people to sit idle is really expensive.
So pedigree is both important and not important?

I'm sorry, but I disagree in so many ways. Do you know how a school becomes renowned? Even then, there are countless people who have thrived without pedigree, without renown, and taken a path less cut-and-dried. I dread a world where such a narrow path is prescribed and must be adhered to. Reminds me of the puritans.

The entire purpose of an arts education is exploration of humanity. Thank god people still naively pursue that endeavour.

To me it sounds like the problem actually lies in the systems of student loans, not people's spirit for venturing into the unknown of whether or not it will financially benefit them.
The idea with oasis is to choose smaller software with fewer dependencies that offsets the slightly higher disk usage, as well as to deliberately not have thousands of binaries.
Semiconductor chip detects antigen at 1 parts per quadrillion molar mass
> It’s been 1 month and 1 day since I last touched my MacBook Pro, so, what do I miss?

> - Better BT support

> - Faster WiFi

Come over to Linux, we have 802.11ac+ and good Bluetooth support.

If you're missing macOS graphics, Plasma Desktop with Latte Dock can make for a pretty and fast macOS clone.
To find the thing which you are good at - is to find the thing which every single amount effort feels well spent even when disregarding any progress.
Oh, that absolutely changes the price calculation for Lambda. Historically the 100ms minimum billing interval made Lambda significantly more expensive than EC2 for large numbers of work loads.
Our terms are the standard termly terms for a social network, however, we have content rating and filtering. Pretty much we only care about public content and reported content if it is breaking government laws that we know about. Otherwise, what's private is private and we'd like to keep it that way.

[Edit] To clarify, we don't moderate based on opinion. Only when we are legally required to, otherwise we let dislikes / downvotes from other members do the talking.
It's Supposed to Be Hard
Those sauces are just different, though similarly named. The calories, sodium and fibre values are different, one contains cheese where the other doesn't.

Sugar is not uncommon in commercial pasta sauce, even in Canada.
Just checked out the app on iPhone. You're right, it feels a lot more natural than the desktop site. I'll continue poking around.

Also, I created the #StarWars channel. =P
There is also the option to use an iPad as a drawing tablet now. We've been doing this for a few years with Astropad. https://www.astropad.com

Astropad connects your iPad to your Mac and so it acts like a Cintiq. We have Windows support in private beta right now and we'll be launching it publicly next year.

This is compelling for a lot of people because:

1. The Apple Pencil is fantastic

2. You get a general purpose iPad as well!

And it is about the same price as a pen tablet with way more flexibility.
Yes, you are still limited to 15 minute maximum duration.

- Chris Munns - Lead of Dev Advocacy - Serverless@AWS
Look into the TIP[0] skill from dialectical behavior therapy. In particular I've found the cold water triggering a dive response[1] very effective at calming me down when I face acute anxiety.

[0] https://en.wikipedia.org/wiki/Dialectical_behavior_therapy#D...
[1] https://www.bustle.com/p/what-is-mammalian-diving-response-t...
Interesting. Not possible today. We'd still encourage paralyzation up through multiple concurrency of functions being executed.
You won't have to recompile everything if you cache your build artifacts (e.g., object files); you'll only have to relink which is quite a lot better.
Well yes and currently there is no alternative to a webbrowser which needs a lot of RAM for these tasks ... which was the main point, right? And not that we could do much better in theory. No doubt about that. But reality is the browser is usually the most pragmatic solution right now to most use cases. Which is good, when I can do online banking in a very niche project like pine, or do you think banks would port and certify their apps for the various linux distros?
Would you say something like that is worth to set up?

I noticed EC2 now has an API to get memory dumps. Theoretically you could automate collecting memory dumps when an unhealthy instance is pulled out of a load balancer. Then some automated analysis could happen, and allow further manual analysis.
This is great. For many high velocity low runtime workloads this is going to be a result in a significant cost savings.
About 7 years ago we brought in the ELK stack for security log ingestion and basic analytics. It took at least three FTEs to maintain the cluster, along with constant issues of queries crashing clusters, or provisioning/building/repairing the dozens of servers and storage units to handle the several terabytes per day of ingest.

To be able to throw that behind an infinite, horizontally scalable mechanism would have saved us a lot of pain and troubleshooting.
hahaha exactly his story makes no sense
I'm curious what brought this article up to the submitter. I choose to believe it is because they recently watched Tim Rogers's 3 hour review of Pac-Man [0]. If I am incorrect, well, here's a link to a 3 hour review of Pac-Man that happens to include much the same information.

[0] https://www.youtube.com/watch?v=GPzVlTgZoCg
Sorry, but are we talking about Desktop operating system? Because if that's the topic, Linux and BSD have much to learn from Microsoft. Including stability. I can tell you, because it's my job: if you don't want to use outdated software, you should go with rolling distributions, that became stable around 2016. Before that every update was a schrödingers update. Windows are able to rollback updates since Windows 2003.

> Between updates and malware spreading behind a NAT, I'm not at all convinced updates are the lesser of two evils.

You can get your answer looking back to events like Nimda and Code Red.
You don’t go for AWS for EC2.

You go for AWS because in half a day you can whip up a secure, managed and auto scaling app using their proprietary services like SQS, S3, Lambda, Kinesis, Dynamo etc.
Well for me it's more like... why should I pay $5/month for the cheapest DO droplet for a little utility web app that gets less than one hit per day?

Seems like a waste to pay for a month of VM time when only a few milliseconds are actually used. I like the idea of FaaS where I'm not being charged when my code isn't running.
They also don't get technical interviews, though.
There's also the the Ameliorated Windows tools that strips a lot of nonsense out of the default Windows install.

[1] https://ameliorated.info/
If you're parents are still around don't take them for granted. You are in a busy stage of life but your parents are nearing the age that health can fail.
Yeah, I just got mine in hand a couple of days ago.

First impressions: the default setup is surprisingly good, for what it is. Works a lot better out-of-box than my Ouya ever did, for what it's worth.

Buttons are a little squishy. Not every app supports the menu button. I've had to hard-power-off the device to get out of certain apps. The back-side strip of buttons is a little awkward, though I understand why they did it that way (it's meant to be an add-on).

There is a port next to the USB port that isn't labeled or documented on the website. I think it's HDMI Type D "Micro".

Hooooly hell, there is ZERO documentation for this thing. How do you actually write games for it? I guess you just make a standard GTK application, from what I can see in the forums. There's support for a few popular fantasy consoles and emulators, but making a native app is not clear.

Also, it has an SSH server on by default, but I've yet to be able to get connected to it. Nothing on the forums about it. They just say "you just SSH in over the WiFi".

EDIT: LOL, whoever put this together before me put the speakers in upside down.
Vimcar | Frontend (SPA) + Backend(Python) | Berlin, Germany | Full-time, ONSITE

Vimcar provides vehicle fleet management for SMBs in Europe, thus helping small companies to keep track where their cars are and optimize how their are utilized.

We are well funded with more than 70k paying customers and more than 100k connected cars. Each of these cars is constantly transmitting live data to our servers (so it is IoT :-D). Our business is strong despite the current situation (November was our strongest month on the sales side), so we want to grow our tech team.

Technologies include Python, Typescript, (recent) Java, React, AWS, Docker, Jenkins.

Office in central Berlin, Germany, close to public transport. Office language is English.

Open Positions, with more details and application form:

- Frontend (SPA) Developer: https://vimcar.de/career/jobs/tech/senior-frontend-engineer-...

- Senior Backend Python : https://vimcar.de/career/jobs/tech/senior-java-developer-m-f...
Here's a course from another author behind Stan on YouTube, working through it myself so can't say how good it bad it is, I think it uses the book too.

https://www.youtube.com/playlist?list=PLBqnAso5Dy7O0IVoVn2b-...
let me google that for you

https://www.cnbc.com/2020/09/29/two-women-file-sexual-abuse-...
Amazon Monitron
https://github.com/aws/aws-proton-public-roadmap/issues/1
StatsBomb | UK/Egypt | Onsite or remote

We're a football analytics startup (both the soccer and American varieties!) We sell data products as well as analysis tools to sports organisations, with a tech stack that includes computer vision, machine learning, stream processing, and web-based dataviz. We count many of the biggest names in football as customers, and your work will have a direct impact on our ability to deliver insights to those customers, driving success on the field. We're hiring a variety of roles:

- Computer vision engineers

- Front-end or full-stack JavaScript engineers

- Clojure(Script) engineers

More details at https://statsbomb.com/careers/, apply via careers@statsbomb.com.
Top Mobile App Trends of 2020
Location: Calicut, Kerala, India

Remote: yes

Willing to relocate: no

Technologies: python (django, flask), php (laravel), html, css, AWS

Résumé/CV: github.com/rashivkp

Email: rashivkp at gmail dot com

I'm more of a backend guy, 5+ year work experience, currently learning angular. Familiar with ci/cd, scrum, shell, jira, git, vim
Ok that's not too bad a cap. I can see that working for quite a lot of use cases that aren't serving websites.
You're 33. That means, unless you strike it rich, you've got 35 more years to work, plus or minus a few. Plan on migrating from what you do now up the food chain to harder things - things that pay better, and where you're harder to replace.

In the end, people matter more than technology. Get better at relating to people, communicating with them, being human with them. You need human connections. As the world becomes more and more impersonal in interactions, find ways to connect with people.

If you're not married, people your age often start feeling like they need to. Choose very carefully. The consequences of a bad choice are horrible; the consequences of a good one are spectacular.

If you have kids, or are about to, they're going to take a lot of your time, energy, and mental bandwidth. Don't give it grudgingly. Love them, don't just tolerate them. Be the parent you wish your parents had been.
Didn't know this existed. I'll definitely consider it if I ever go back to using Windows.

I didn't spend enough time to verify if it satisfies the "can use other clients" and "can add 3rd party repositories" criteria. But assuming it does, I bet tons of people would happily use it, if Microsoft blessed it as the official standard for managing Windows applications / installed it by default.
Well, I came here to comment, but you already succinctly summed up my thoughts. Thanks for that!
Show HN: Maia, a human-like neural network chess engine
No, not any random app. You knowingly chose to install the app. It either came from the App Store or it was notarized by Apple.

There are just so many reasons why software needs to access your hard drive. My app, for example, needs to write files in ~/Library/Application Support/Chrome in order to add native messaging permissions for my extension. Can you imagine the number of "Karens" that are going to email me because they "caught" me trying to "steal their data" if they add restrictions to this folder?

Apple did the right thing by only adding warnings for more sensitive areas like your Downloads or Documents folder, but any more than that and I think it'll cause more harm than good.

I agree with the blog post. Apple seems to be more focused with "security theatre" right now (or at least half-assed security for the sake of marketing). They do things like add easy-to-implement (via their FileManager class) file access warnings to appease most non-technical users. But at the same time ignore bigger looming threats like apps accessing the Internet. I think the issue isn't the warnings, it's what the warnings are about.

Anyway, my guess is that Apple will be adding network access warnings in the future (since it seems they re-wrote a large chunk of the networking code recently) but let's not deny the two-faced marketing speak going on right now and fact that they do stuff like making it impossible to inspect network traffic from Apple apps. The hand-wavy "trust us" argument shouldn't work for Apple either. Why do I have to trust Apple more than a third party developer?
Thank so much for the summary!
> Amazon Monitron includes sensors to capture vibration and temperature data from equipment, a gateway device to securely transfer data to AWS, the Monitron service that analyzes the data [...] and a companion mobile app to set up the devices and receive reports on operating behavior and alerts to potential failures in your machinery.
They're not easily comparable (I tried using Cloudflare Workers before going back to AWS). Lambda@Edge runs Node or Python. Cloudflare Workers runs V8 with "worker isolates" which has a few more caveats, an imperfect but improving dev experience, and doesn't work with a lot of npm packages.
> When I visited Pittsburgh last year, I only found one (!!!) downtown.

To be fair, my impression of downtown Pittsburgh (that is, the golden triangle -- this was a few years ago, so things may have changed) was it didn't have much residential density. Things seemed relatively quiet after 5 and the area didn't seem to have much foot traffic. I also was given to understand most Pitt and CMU folks (the intelligentsia of the city) don't tend to live downtown. I did manage to visit a comic book store.

Brick and mortar bookstores do require a certain amount of foot traffic to be economically feasible. Although Amazon Prime is hard to beat for sheer size of inventory, below MSRP prices and fast/free shipping, booksellers still have a few cards up their sleeve. The booksellers near me that were doing ok pre-COVID had great browsing experiences (well-curated collections, nice furniture and adjoining cafes) and frequent book events by authors. Sadly with COVID these advantages were lost. (also, I hate to say this, but customer service in a bookstore generally doesn't really make or break it. I rarely interact with the staff.)

Since March, I've bought a couple of books from Bookshop.org out of principle. The books were pricier (closer to MSRP), shipping was more expensive and slower, and there was no other value-add, but I knew I was paying their true sustainable economic cost.

I guess the real problem isn't that Bookshop is expensive, but that Amazon is so cheap (and convenient).

(also, despite what purists say, Amazon's b&m bookstores are actually really good -- the curation is excellent because it's based on analytics. So Amazon is encroaching on b&m booksellers' territory in that way too.)
Wow, other people clearly use lambdas for far different purposes than I do!
Money cannot buy you meaning, but my points were not that... they were that:

1) Saying "well sure you have money but money won't buy meaning" is usually just a self-defense mechanism. "Well I don't have the money, but at least I have meaning [questionable] and he doesn't [also questionable]." Money and meaning are probably uncorrelated. If anything I'd expect an average(!) person with money to have more meaning than average person without, given that by this only point of evidence, they are better at goal-directed behavior of some sort.

2) The 2nd point is the meaning is unnecessary. I am not sure how elaborate the religious life of subsistence farmers was, but I don't think they were looking for anything like meaning in a modern sense... Ditto for getting high on plants. It strikes me more of a curiosity motive to explain the unknown, the kind the drives modern science. To the extent that it involved meaning, it was more of a meaning of the person as a cog in the now-explained world, not some transcendence. Even the nobles/etc. would see their meaning in advancing the agenda of their city-state or smth like that. Going by modern cosmology, there's no inherent meaning in the universe, so any one you choose is just the one you create (arbitrary), or more likely someone else creates for you with their own questionable motives.

When I started thinking more of the finite-ness of life given the above, I found that it's not the lack of meaning that's the problem, it's the search itself. In this paradigm, money isn't everything, but time and experience is; and you have far more time and better experience in modern society if you have some minimum cashflow. Ideally, you need e.g. $60-80k/year (iirc that was the happiness plateau in the studies for the USA), ideally without sacrificing ~50% of your waking hours for it.
> “There are 3 things in life that people like to stare at: a flowing stream, a crackling fire, and a Zamboni clearing the ice.”

I've heard what is supposed to be a Russian proverb along these lines:

> Three things does the eyes not get tired of: the water which flows, the fire that burns and seeing people work.

This absolutely sounds like an older quote (if true). Do anyone have any pointers? My cursory search only brought up the Zamboni version.
Speed has never not mattered; whoever told you that hand waved over a ton of nuance and did you a disservice. The reality is that for a lot of work loads an increase in speed is not worth the tradeoff (key word) of increased maintenance burden.

All else being equal, faster services are cheaper to run. Faster services can service more requests per compute/memory resource, which means you don't have to buy as many servers/containers/whatever. This is particularly important if you're being billed by the ms, which is the context we're talking about here.
There is an error in your LinkedIn link
https://www.linkedin.com/in/jj-reibel/
ECS (potentially on Fargate) would be a reasonable stack for those tasks, given the 15 minute limit on Lambdas.
Heres ms2pg https://edoceo.com/dev/ms2pg

A tool I made and used over a decade ago when migrating a bunch of stuff
To be honest, if it's a static site and you just need a little bit of compute... Cloudfront in front of S3 and lambda is probably the cheapest way to give someone a basic website (just a contact form and nothing else)
Before physical activity, stretch out. After an injury, recover before you try to go full out. You're not 22 any more.
The "blog post" is really a full example of our wiki software, thus they heavy payload. It's not an example of solving the problem... yet!
Over 15 years of the US defunding basic research is taking its toll...
Do you sponsor visas? Would be very interested in working out of Israel.
On demand pricing dropped our DynamoDB cost by ~20%.
He just released an update video following the collapse for those interested.[1] There's also some drone footage of the remains.[2]

[1]: https://www.youtube.com/watch?v=vchDbyIRP44

[2]: https://www.youtube.com/watch?v=GRHXCWr7xt0
Get started with Kubernetes the Release way