skysight-inc/HackerNews huggingface dataset:
Stability "like academia" is rich, given all we've heard about "publish or perish". Modern academia is a poor fit for increasingly any case you can think of besides maintaining the status of academia. But sure, there needs to be some stability and ability to "fail"/i.e. produce something worthless. Corporate research departments provide this -- if they didn't, they wouldn't have a research department and indeed many don't, nor do they need to, but this has little to do with quarterly returns.

We've also seen a rise of VC-backed research startups (like DeepMind but many others) whose value proposition (to the VC) only makes sense if the goal is to demonstrate a research capacity to get them bought out by a big company, or as a moonshot to out-compete them on an actual product made possible by the research. Investing in these little research startups themselves is also giving companies a way to push research without having to deal with having the researchers as direct employees, and I'm sure makes some of the startup employees feel a bit safer since there's a separation of money and operation influence. One similarity with modern academia is it selects for those who can do good work but who are also good bureaucrats (write grant proposals well, advising politicians, etc), startups have a selection for good work + good at courting VCs. But the startup just needs a few of them, then they can hire people who just want to do good work.

Another thing that makes corporate even better is they can occasionally spin off research developments into products, they can have some nice advances that only come when you try to productize, and among other reasons by not having to bother with external publishing (which takes time + fights with lawyers and business people) they can routinely be 10+ years ahead of whatever the state of the art in academia is.
Well, the first step to making something happen is advocating a position that would actually achieve your goals.
Can it simulate two proteins interacting? IE search for the simplest protein sequence that a.) doesn't affect folding geometry when paired with every known human protein and b) causes the greatest deviation when paired with covid-19 proteins?
MTLS
I think the inexpensive treatments are abused by many different actors because they carry little or no cost to develop, thus there is reason a to be sceptical.
For example you can find a lot of supplements that claim to cure various cancers and many have been proven to have no effect. People even claim that objects or they by themselves cure diseases.

If not much money or effort has been put into a 'treatment' you have reasons to sceptical, don't you think? It's like working in the financial services and someone is trying to sell you a $10 e-book that will make you rich in 1 year. It could do the trick but I bet you would be sceptical.

Testing/clinical trials usually cost a lot and even if the treatment it's not great, at least you have some hard data that you can rely on.
Your first source does not support your statement.

While there is theoretically a quadratic component, in their words:

> We found that, at least for the design space and technologies we explored, the quadratic component is very small relative to the other components. Hence, the delay of the decoder is linearly dependent on the issue width.
The choice to run businesses in particular ways, not political freedoms or freedoms accessible to most working people.
In essence, I'll worry about the death of the open web when people can no longer make mcbroken.com
with everything else going on maybe we'll see virtualbox guest additions for macOS
Yeah, I was about to buy an Apple laptop since I also have been doing more and more cross-platform app development. Didn't like borrowing others' laptops and doing the laborious process of switching to my icloud profile just to upload some apps to the app store.

I'm definitely out now. I was never the target audience for Apple products anyways so maybe they're not too worried about this
> Do you have long term friends locally?

Not really sure what that means, but most places we go we have friends we’ve known for many years, and those are often other nomadish types.

> Is your wife your anchor to a local community?

No, she’s from even further away than me
There was a large difference between northern and southern Italy described in this paper (from June so maybe things have changed since then). Note that northern Italy only has a slightly higher population density that the authors didn't think was significant.

https://onlinelibrary.wiley.com/doi/10.1111/eci.13299
Apple fined €10M by Italian watchdog over iPhone waterproofing claims
What are your levels when you use supplements?
Dedicated servers is not a "new thing".
Woah! Are they adding the M1 chip to/in their datacenter servers/blades?
The problem is that when somebody comes along with huge amounts of money and some terrible ideas, F1 can't help but give them a slot on the calendar. Tilke gets a bad rap for this, but tbh he's mostly not to blame (he has made some incredible circuits, as you mentioned). Sochi, Yas and Hanoi are all terrible though (thankfully we never will get a race in Hanoi).

I'm against the idea because there are so many good tracks to host races at, and I don't trust them to build new ones that are any good. They've proven that they're more than happy to put on boring races for anybody who has enough money. The fact that Abu Dhabi is the last race on the calendar, and that they're planning to put Saudi Arabia right behind it guarantees that having an exciting title-deciding season end is just logistically impossible now. I mean, is there a single person in the world who thinks that KSA is going to have a decent circuit?
My first thought was NIMBYs as I used to live somewhere where people started buying properties near the college bar scene and then trying to find ways to get them shut down, but this makes sense as well.
You’re making a choice to see fetal tissue as a baby or an unborn child - something that is not in any way inherently true.

Since there are opposing strongly held viewpoints on abortion and neither can be proven to be more correct than the other - neutral language seems like the best way forward.

You can claim the language is biased, but as a medical procedure it’s coded in all the same language as any other medical procedure - which seems to me to be the neutral thing to do. How you feel about the emotional or moral content of a medical procedure is separate from what is done.

To take a less emotional example - I think genetically modified organisms are basically a bad thing, but that doesn’t make the term wrong - calling them monsterplants would make me happy but it’s not more accurate and it linguistically enforces a viewpoint that is not “correct” just because i happen to hold it (for many nuanced reasons i won’t go into here)
MacOS AMI images, EBS disks, VPC networking, 10gbps ENA. Bare metal only, Intel available now, M1 coming soon. This is another game changer.

The post says they’re based on Mac Minis, but also use AWS Nitro. Is this custom AWS specific hardware?
At the very least, people might do some additional research before engaging in surreptitious “journalism”.
I can't seem to find pricing for this - anyone understand AWS better than me?

It's not listed on their dedicated host pricing page at https://aws.amazon.com/ec2/dedicated-hosts/pricing/ , and if I go through the web console to create an instance, I'm prompted to create a Mac dedicated host without any indication of how much I'd be paying.
I’ve read a lot from Djikstra, but never this one. After giving it a read, it’s one of his most concise summaries of his overall philosophy. If he’s wrong about anything, it’s how formal methods are not up to speed with the scale of software that we want to build, and that I believe we can never get away from operational reasoning.

I’ve been keeping a bug journal for some time now. It’s very enlightening because instead of making things up, I have raw data about what goes wrong at work, for me. For me, logic errors account for probably 40% of bugs. Another 40% are operational problems, mostly performance related. The rest are typos and unintentional breakages of parts of the program that are unknowingly coupled to something I changed.

All that being said, even when he’s wrong, he’s right. Logical soundness must come first. This cannot be done without math. All programmers are doing math whether they acknowledge it or not, specifically mathematical logic and set theory. Refactors to improve performance must keep the logical function of the program the same.

I believe him wholeheartedly when he says:

> The statement that a given program meets a certain specification amounts to a statement about all computations that could take place under control of that given program. And since this set of computations is defined by the given program, our recent moral says: deal with all computations possible under control of a given program by ignoring them and working with the program. We must learn to work with program texts while (temporarily) ignoring that they admit the interpretation of executable code.

This man understood computation far more deeply than anyone out there today. Today, we have completely baseless claims being spouted like religion. We are in the era of the personality - a person’s personality determines how much they are listened to in our field. That is tragic, and while Djikstra might not have the answer for software of our scale, he has the only correct point of view in my opinion.
That's not true. There are many lower rated schools in Sunnyvale and San Jose. But it's inconsistent; there are pockets of high and low ratings even within single school districts.
AWS Lambda now bills in 1ms increments
You only need it for compiling. There are plenty of cross platform frameworks that dont require to develop with xcode - and that's good in my opinion.

I built all my apps this way and faced the same problem as OP - so had to buy a Mac mini. It was the cheapest option ~8 years ago and I still use it today for the same purpose - just for compiling. I assume there are probably more of us.
"Treat it as if it were a preprint" is different from discounting the paper.
Is it the method of teaching really? Or is it that good-enough, quickest to market, and diverse programs often win in a capitalistic market?

Capitalism is all about finding new opportunities. Nothing is static. Pedagogy or otherwise.
X-ray diffraction is pretty nutty, too. You're taking the diffraction pattern, which is the fourier transform of the electron density. Fourier transform results are complex-valued data. Unfortunately, we don't really have X-Ray lasers, so you can only get the intensities and not the phases of those diffraction spots. Since mother science hates us, it of course the case that, in a fourier transform "more information" is contained in the phases than in the intensities.

So you "make guesses at what the phases are", the best choice is to bootstrapping these phases measured with another technique (you can introduce crystal defects that do allow you to guess at what the phases are).

Less scrupulous is to use a computer generated model, like fitting another protein "that you guess is related", then you model the electron density, take the phases of that.

In any case you take these "phase" guesses, and then apply it to your intensities, re-run the fourier transform, refine your electron densities, twiddle the location where you think the atoms, are, then repeat with your new model. This process repeats until you converge on a structure that you're happy with.

Now alarm bells should be screaming in your head right now: Yes, it's entirely possible to converge on a wrong structure, especially if you're a young up-and-comer professor seeking tenure that has no ethical problems with "suggesting" their grad students to sleep in the lab and work 100 hour weeks and willing to do slipshod work to get you tenure: https://www.sciencedirect.com/science/article/pii/S002228360...
Through a number of classes I took online and in person with online homework, the immediate feedback was the one thing I really appreciated.

Statics is very much a class where the same basic concepts are applied tons of times in different ways, and you kind of need to see and do a lot of problems to get good. My professor had us do online homework with unlimited attempts, but we had to submit our hand written work as well. Even though that class was entirely online, I felt very confident applying what I learned on projects.

The immediate feedback was 10x better than having the week or two of lag, and 9x better than having the answer on the back of the book because I never ran out of problems to try.
Where I live (Brazil) they use their normal patty for the quarter pounder... it is a completely useless sandwich to be honest, the quarter pounder is almost identical to the cheeseburger, except the cheeseburger is even smaller somehow. It is really sad.

The quarter-pounder here is nowhere near 1/4 of a pound. (seemly they use a 0.2 pound one instead. or 1/5 of a pound)

I actually paid attention last time I went, in more than one store, I ordered quarter pounder and kept watching the drawer, not only they used the drawer, but the burger that went into quarter pounder is same that went into all other products.
I have done it once successfully in 10 years (.NET dev). Would recommend having any other kind of logging or instrumentation in place so you don't have to do it. It's still worth learning WinDbg and sosclr.
If the current offering is Mac Minis, chances are Amazon has built an industrial grade version of what https://www.macstadium.com/ offers, and have racks with tons of Mac Minis, probably with custom ducting for A/C and so forth.
As someone who believes abortion is entirely ethical, I don’t really like the framing of your statement - but yes there are ways to obtain embryonic stem cells that don’t involve abortion - specifically the unused embryos from IVF
Now when will macOS support native containerization?

note: see https://news.ycombinator.com/item?id=21333408
> When I see these complaints I see people talking about how they want other people to use the Internet and computers. That smells like authoritarianism.

It's authoritarianism to politely suggest that people do things differently?

No one is proposing that we outlaw the corporate web… we're just trying to make the web a little less corporate.
Yes, AIUI AWS Nitro is a PCI (in this case thunderbolt?) disk abstraction system that fronts EBS for the host.
You have to be logged in to see the prices.
I wander about the pricing...
The current offering being announced is Mac Minis (presumably rackmounted by being on shelves, or something), and the new Mac Mini is M1-based.

The macOS EULA says you can only run it on Apple hardware, so your options are basically Mac Minis or the new rackmountable Mac Pro.
The easiest way I've found to get MicroG working properly is through Nanodroid:
https://gitlab.com/Nanolx/NanoDroid

It takes an existing ROM, patches it for signature spoofing, and bakes in a bunch of FOSS apps. (But the installer is fully customizable so this is optional.) It also can (try to) patch non-LineageOS roms, so if you're stuck with an unsupported Android build, it can still gut out some of the bloat. I actually used it with my vanilla LineageOS install because the maintainer also packages a patched version of the Play Store that still supports in-app purchases so you can still use your paid apps with MicroG. Overall it's been a great experience for me, my battery life is way better than before and I feel much better about what's running on my phone.
Over Thunderbolt:
https://twitter.com/_msw_/status/1333629867171057664?s=21
A Life Soundtrack
Does it have been that he's ill informed? Couldn't it be you & he just disagree?
Wikipedia exposes paid editing scandal
Ask HN:Can identity providers work without storing any user data?
Is it reasonable to think about an authentication solution where identity provider do not hold any user-data (hence acts like a stateless server) and the service provider (or relying party) gets verified data directly from end-user?
this is great advice for the summer, but doesn't work so well in the winter, when the UV index is a small fraction of summer values and air temps are not conducive to skin exposure.
previously : https://news.ycombinator.com/item?id=25255113
US Congress S.3571 Banking for All Act
$999.99 per month. "We wanted to redefine how people interact with macOS, on a deeper, ... and more granular level. Truly redefining the user experience and rethinking what was really possible, in the cloud."

Slogan for new product line: "A silver lining."
Alternatively, Apple might gain revenue from iOS and macOS builds becoming more accessible, allowing more small businesses to support their hardware.
Wheeler wanted to allow paid "fast lanes."

https://www.nytimes.com/2014/04/24/technology/fcc-new-net-ne...
I am logged in, and I see prices for other dedicated host types (and I saw them even before I was logged in) but not mac1.metal. Do you see the price?
No mention of pricing that I can see, and I don't see it on ec2instances, AWS's pricing page, or the spot-pricing widget on the console.

Am I missing something?

Edit: And the reserved instances widget (I was going to guess based off this cost) just flat out breaks when you pick mac. I guess we're still in the "If you have to ask, it's too expensive" stage, or something.
How to own every opportunity out there
When operational a fusion reactor has less then a couple grams of fuel in the vacuum vessel.
> And we know the VAST amounts of cash devoured by SLS and the traditional folks who critiqued SpaceX approach.

I was going to say to look exactly at its endless money pit counter-part: SLS from ULA. Nothing will ever compare to that monstrosity that will never work: $7.2 Billion and growing [0].

Also, not an Engineer, but went to interview at both Tesla and SpaceX and SpaceX's internal facilities are jaw-dropping. People love to go on about Tesla's Fremont factory, which is awesome, but I've been to Fremont and Boca Chica. And Boca is by far more impressive; I lived and worked in Emilia Romanga in Italy, and also lived in the town nearest to Stuttgart in Germany so I've have seen my share of amazing engineer and logistical/distribution feats.

I saw them starting to stack what was to become SN3 (RIP) in real time in the hangar as I saw SN2 vertical on the launchpad which that still remains one of the coolest things I've ever seen in my Life. I was basically leaning up against one of the Raptor Engine prototypes they have pretty much just around.

I've also got a few glimpses of the Hawthorne factory from (the outside) when I was charging the Model 3, lots of cool stuff comes out there (namely Falcon 9 and Merlin and Raptor engines) they have so much cool stuff just lying on the side of the building which I took pictures of but was asked to delete by security, which I complied.

0: https://oig.nasa.gov/docs/IG-20-012.pdf
Ranked: Spoken Languages Around the World
A lot fewer molecules of e-waste with the tiny SoC, at least.
Maybe using something like Expo: https://expo.io/
I'd argue that is already is. Wasn't there some big controversy about a SuperMod that was paid by companies to manage Reddit for them all day?

The only place left for good recommendations is the same place that was good for it all those years ago - closed small niche forums (discord servers fill that gap nowdays) and personal recommendations by people you know in real life
Awesome.

I'll still keep a Mac mini since I like Logic, but this is very very good for say a Unity or Flutter developer who needs to deploy apps to iOS
Building a dyson swarm, or even a fraction of it would be the real game changer. Distance from sun to moon - 148,000,000 km. Radius of earth - 6,370 km

fraction of light emitted by sun falling on earth
(pi6370^2) /
(4pi*(148e6)^2)
= approx 4.6e-10 or 0.00000000046 or 0.000000046%

To put it in perspective - if we could collect 100% of the light energy emitted from the sun each day, it would amount to the energy that the earth receives from the sun in 6 million years.
Ah no, sorry, the dedicated hosted pages used to not show any price when not logged in.
Any chance you remember which video this was? I can't see it in the dotnet conf 2020 playlist.
And South Korea at 510/km2 and Taiwan at 651/km2...
This was over 5 years ago, before those projects existed, or at least they weren't on my radar at the time.
Can't see the article. Did they control for obesity?

You have a single factor highly correlated with low vitamin D serum concentrations, ACE2 expression, and comorbidities associated with covid-19 mortality.
This could be huge for the ecosystem. For example, there are ways to use third-party iMessage clients (e.g. through Matrix) that require you to keep a server running on your local macOS machine signed in to your AppleID - this could let developers create hosted versions of those services
$1.083 per hour, but you have to pre-pay for 24 hours to start one up. After that, it's billed by the second.
"The instances are launched as EC2 Dedicated Hosts with a minimum tenancy of 24 hours"

These are just rentable Mac Minis, not VMs. This will have only one use case and that's for build servers. Unless anyone has scalable AppleScript jobs to run?
This is an interesting thought. Sounds correct to me. It seems like ending the War on Drugs would be a conceptually simple way of fixing most of this.
Those AWS images running OSX aren't free. Apple is definitely getting some royalty.

And that royalty is basically very low overhead. Keep in mind, hardware isn't software, and it does have a very high overhead.
I had to think about this but my answer is boring: "He picked the right themes and aesthetic at the right time."

Cyberpunk would have happened without him (Blade Runner was released first), but most things are like that.

He'd also studied English, which helped give him some sensibilities that would appeal to tastemakers. Neuromancer wasn't genre fantasy and it wasn't hard SF. (Even then, the name turned many people off.)

And I guess he won some powerful allies early on in what was then the SF establishment.
Where do you see anybody thinking that "came from using containers or the cloud"?
> Furthermore, pointing out that people with darker skin are not adapted to live up north could easily be misconstrued as an anti-immigration stance.

True. That can easily happen. Reason enough to not push that angle, at least not directly. There are other ways of phrasing that.

Besides, for humans, there's no longer such a thing as "being adapted" to the environment, at least not in that limited sense. This is not an Earth versus Mars thing, it's just a matter of latitude.

If natural abilities were such a big factor, we wouldn't need clothes in Norway or Canada to survive in those places, in winter. But we do. Plus heating.

Humans are not "adapted" to live in all environments on Earth, at least not without tools, which includes clothing. So, if your skin is light and you are in an area with high insolation, cover up more and try to spend less time in the sun. Add some sunscreen too. If the skin is darker, do the opposite. Add some supplements as needed. Done. Adapted to the environment.
It seems like a likely explanation is that these are primarily done by children and that this is a human universal / instinctual behavior during child development. Looking at google scholar there are at least a couple studies of hand print sizes estimating that in a few regions they were almost exclusively done by young people. That would seem to suggest a biological basis for this specific behavior.
USD $ 450 (price) buys 72 reams of paper (amazon) which also requires a lot of storage :^)