skysight-inc/HackerNews huggingface dataset:
You can't look at a market as a 2 week window which corresponds to a new product release. Your results are going to be greatly skewed.

The Mac mini is cheap and has surprisingly good performance. It is the absolutely perfect gateway into Apple's next generation of computing. Someone at Apple should get a merit badge for including this in their initial launch because it was genius.

That there is a big initial spike in demand is completely unsurprising unless you were asleep at a wheel. Much much more interesting is going to be what these numbers look like after Apple burns through initial pent up demand. Won't see that for 6+ months.
So the economic situation in the US is not as amazing as it was before. So what ?

Compared to the rest of the world, people in the US have it easy.

Heck, in many places in the western world, people can't even afford to buy an apartment , which many in the US own or will own houses.
Lichess (a popular chess site) combats this issue by not actually banning cheaters. Instead, the cheater is not notified that they were caught and is still able play or create games, but they're only matched to other cheaters.
>>> Check the Referer header

Warning on this. Many browsers always leave the referer empty nowadays. A user with no referer is very likely to be a human.
Like this is awesome and a huge advancement but one thing that worries me with an AI solution is that it doesn't really draw us any closer to the why. Why do proteins fold the way they do? We can predict the resulting structure which is extremely significant, we have no clue why. While we get the insight of being able to predict some structures we don't get the insight of why things are happening the way they are. In some cases like this it might not matter but in other cases that insight might actually be way more significant than answer the problem to begin with. Of course we can review over the problem with the additional predictions that AI gives us but this can be haphazardous because what if there is specific sequence spins in some certain way that we and thus the AI has never seen and it goes missed. I'm not a biologist to say this is possible but I known this kind of edge case can come up and what rabbit holes will we go down because we only have the AI implied insight.

disclaimer I think the contributions are super useful for science but they do come with worries as does every path of discovery
No we won't. The only people not having kids is the educated class. There are plenty of poor minorities with many kids. Japan does not allow widespread immigration like the us does.
This is nothing to do with that.

It is about a company in one (or more) EU countries blocking access to people in one (or more) other EU countries.

"Sorry, this item can't be delivered to Denmark" seen on Amazon.de is presumably one example, another is downloaded media.
You do get tax breaks, and a number of other benefits (in particular related to having children). You also get a tax break on a certain amount of paid interest on a house purchase.

Plus, there's the whole " allowed to be next to your loved one in the hospital" thing that's overlooked until it's needed.

So, no 40 acres, but there are benefits beyond two incomes.
Cyanogenmod is still alive and thriving as LineageOS. The goal was never to beat (Google) Android, it's just a custom ROM that provides many desirable features.
I think tpmx's point is that the virus would also be less dangerous for them, so getting the vaccine has less chance of having a net benefit for the individual.
From: https://www.sciencemag.org/news/2020/11/game-has-changed-ai-...

“The organizers even worried DeepMind may have been cheating somehow. So Lupas set a special challenge: a membrane protein from a species of archaea, an ancient group of microbes. For 10 years, his research team tried every trick in the book to get an x-ray crystal structure of the protein. ‘We couldn’t solve it.’”

“But AlphaFold had no trouble. It returned a detailed image of a three-part protein with two long helical arms in the middle. The model enabled Lupas and his colleagues to make sense of their x-ray data; within half an hour, they had fit their experimental results to AlphaFold’s predicted structure. ‘It is almost perfect,’ Lupas says.”
‘Biology’s ImageNet Moment’, DeepMind Has Cracked Protein Folding Problem
Google’s UK-based lab and research company DeepMind says its AlphaFold AI system has solved the protein folding problem, a grand challenge that has vexed the biology research community for half a century.
You are correct, I am actually asking to pay more taxes if some of these problems could be solved.

What good is having a lot of money if you're surrounded by problems and are unhappy? I would gladly spent it to make my community more egalitarian.
I'm a Journalist Who Hates the News
> Pretty sure the point is that Apple is now the #1 desktop manufacturer in Japan, and they weren't before.

Over a 2 week period.

It's pretty rare to see market share over a 2 week period because product launches skew the hell out of these numbers.
So, sorry to be a philistine but what specific discoveries will this lead to... will it make it easier to produce antivirals or even molecular machines?
no, not by a long shot. It's expensive comparative to local socal jobs but not to tech salaries(both me and my wife work in bay area tech companies). For comparison I want to live in 3/3 bdrm house in a good school district that does not need a total overhaul. In the Bay Area, good school district cities (Palo Alto, Cupertino, Menlo Park, Los Altos, etc) all have houses priced close to $2M+ starting for a 3 bdrm house. In socal where I live now places are 800k - 1.1M and the schools are 9's & 10's. The mortgage we now have is 40% cheaper than the bay area house we had, and in the bay area all of our schools were 3's and 5's.
Slack logs are a liability. It’s absolutely not a feature to me. It solved a problem they created: claiming working synchronously is better than asynchronously and pushing people away from things like wikis and email.
It's not the skills the get you hired (it's not like companies are seeking history majors), but rather the degree is a signal for competence and conformity, that does.
How would anyone get capital to do anything if you could see 5% gains just sitting on the money? How many fewer tech giants and unicorns would we see?

We already know what happens when people aren't incentivised to invest - it's called a recession.
My WFH routine is basically to just sit in the sofa all day watching movies or play videogames, lie about my progress in stand-ups and then pull an all-nighter before deadline to produce the expected results. Not that I was very productive in the office. About the same output but much less time-efficient since I had to sit there for 8 hours.
These specific examples aren't counterfeit. But wirecutter had a good breakdown of the breadth of counterfeit products sold on amazon.

https://www.nytimes.com/wirecutter/blog/amazon-counterfeit-f...
> I wondered if the popularity of 'The queen's Gambit' would lead to a brief infatuation with chess in the popular imagination

According to Google interest in learning Chess has tripled because of The Queen's Gambit: https://trends.google.com/trends/explore?q=how%20to%20play%2...

> I'd never be sure my opponent wasn't just putting the moves into a computer and playing whatever it told him to play

I play regularly on online and it really isn't an issue. I'm sure an opponent or two has cheated, but to me it doesn't matter. Either way I just play the board. If it happens I'm just playing a harder game and maybe learning something new. My rating isn't important enough to me that a game or two lost to cheating is not a big deal. I've also had Chess.com reverse games a month later that they have detected the player as cheating.
chesstempo is neat because they have ELO-like ratings for tactics puzzles. It's the first place I saw such a thing.
Exactly. I've been holding off upgrading my parents Mac mini until the next generation ... this is it.
I don’t know how true this is for foreign companies operating in Japan, but weekly sales reports are fairly common out of the Japanese market.
Apple M1-powered MacBook successfully runs Windows 10
Overtakes, not takes over.
See, this isn't necessary in other languages. All I want is an error, so that I can assess what the right thing to do is.

Honestly, I sometimes feel that people have stockholm syndrome with python packaging.

Nonetheless, I'm really happy about this release, as it will help to prevent these problems.

It's also worth noting that I didn't even learn Python for a long time because I kept breaking my install while trying to get started, so this stuff has real costs in terms of adoption.
Yeah I’m kind of surprised an article was even made. This is true for dozens of people/positions. I get no one likes Pai but this isn’t exactly news.
Not on this site, but click the "jsbeeb" button underneath the emulator to open the code on a full emulator.
I'd love to consider leaving Apple, but there's something that keeps me that I'm not willing to give up: industrial design. I look at the rest of the market and wonder what the hell they've been doing for the past decade...

Why is it all "gamer" hardware that looks like a Michael Bay movie? Maybe there's a carve out for things that look like they belong in a cubicle farm. Cheap plastic, laptops with bad battery life and worse cooling, inferior trackpads, and screens that don't quite hit the mark no matter where you look.

I'm willing to accept that Apple buys the supply chain and makes it harder, fine - but why is there not one single company that makes something premium that I want to have in my office? I'll pay a premium for it, cost literally does not matter - just give me something nice. I could get a good looking desktop from System76, but every other monitor makes me cringe now.

If the market is this much in disarray, I have no idea how they compete against the M1's internals. Ceding the premium market to Apple is the most depressing thing ever.

And none of this is even touching on comparing macOS relative polish to Linux and its various DEs. I think that macOS is tricky with changes, sure - but if you know how the OS works, there's really very little surprise with it.

tl;dr: would the rest of this industry please wake up and actually compete?
It is presumably good that we will have a variety of vaccines. This way if one of them has unnoticed harmful long-term effects it will only affect a subset of the population.

Is there some sort of system like this for flu shots? Or are we injecting a large portion of the population with the exact same stuff?
Sketching during meetings led me to create these books
exactly. go to any poor, inner-city neighborhood. lots of young people
Ah, thank you for the unfading. Sometimes comments that seem to be vaguely political gets downvoted kinda fast in this site. But nevertheless, I was just trying to connect the theme of this short story to a well-known phenomenon of "retrograde nostalgia" that is not just a symptom of political right but also to the political left. In that regard I view Gibson and this story as quite a visionary, predicting the cultural sentiments that would define the neoliberal era, before Derrida and Fisher.

And also, there are many literature papers on the connection between the Gernsback Continuum and hauntology on the Internet - I've read a good piece before but the PDF link is kinda broken at the moment and cannot find it anymore.
What is your point? This seems pointlessly blame-y. Those who just graduated from high school and entered college have been told by figuratively-literally everyone that that is what they should do. Then they do it, and it turns out it is a terrible idea for a variety of reasons and there is an ill-timed pandemic that cuts off the few reasonable opportunities that they might have otherwise had.

But sure, let's blame those foolish, foolish young adults for their crazy choices.
> I looked at two solutions, both of which were more expensive than I had liked. The first was to get 10GbE Ethernet cards for each PC using the newer Cat6A copper cabling...

> The other solution was to purchase Converged Network Adapters for each PC and run MultiMode Fiber (MMF) instead of Cat6A.

Cheap routers and NICs supporting 2.5GBASE-T and 5GBASE-T can't arrive fast enough.
Electric propulsion makes this French submarine concept extra sneaky
Isn't it good that people who build things you oppose are incompetent? I would unironically celebrate that.

For example, I'm happy that the CIA/FBI are occasionally incompetent because it hurts their ability to meaningfully implement and reduces the worst impacts of mass surveillance.
I have to push back on this. Salesforce backpacks seem to be a huge hit with the homeless. I've seen them in multiple major cities now and they are almost de rigueur in SF.
Inigo has a rare and brilliant mind. I wouldn't be surprised if he just... thought about it in his head.
Increases in housing and healthcare costs have been absolutely dwarfing wage growth in most major metros, for decades now.

This "it's your fault for majoring in gender studies" meme is a red herring. There was a time in the U.S. where one parent could support a family and purchase a house while the other stayed at home with the kids. With nothing more than a high school diploma.
GEB – A Tcl/Tk GUI for SQLite
> Not sure what you mean by that

I spoke loosely, my mind skipped ahead of my writing, and I didn't realize that we were parsing so closely. "Genetics (the field) is amenable because the object of its study (the genome) is a sequence" would have been more correct but I thought it was implied.

> without a specific purpose there’s no point in doing so

Well yes, prior to the success of transfer learning I could see why you would think that is the case, but if you've been following deep sequence research recently then you would know there are actually immense benefits to doing so because the embeddings learned can then be portably used on downstream tasks.

> it’s purely limited by data availability.

Yes, and transfer learning on models pre-trained on unsupervised sequence tasks provides a (so-far under-explored) path around labeled data availability problems.

I already linked to a paper showing a task that these sorts of approaches outperform, and that is without using the most recent techniques in sequence modeling.

Maybe read the paper in Nature that uses this exact LM technique to predict the effect of mutations before assuming that it doesn't work: https://sci-hub.do/10.1038/s41592-018-0138-4

I am not directly in the field, you are right - but I think you are also being overconfident if you think that these approaches are exactly the same as the HMM/markov chain approaches that came before.
Do you have a source on this 500b allocation? Not finding anything on a quick search.
A Mini size of the AppleTV would be great.
Link to the article: https://eng.lyft.com/changing-lanes-how-lyft-is-migrating-10...
I went the opposite direction - having had a custom-built Windows/Linux dual boot monster for a long time, I traded it out for a 2019 Macbook Pro a few months back. I've been nothing but happy so far.

For context, I'm a DevOps engineer, a web developer, a tabletop game designer, and a gamer.
These accusations against Tether are very outdated. Read Matt Levine's take from 2019 on an ongoing lawsuit: https://www.bloomberg.com/opinion/articles/2019-04-26/things...

The quintessential part is this: The New York attorney general’s filing refutes the extreme version of those doubts — Tether mostly had the dollars — but it is nonetheless a wild ride that alleges that Tether’s backing might not be as good as it claims.
Isn't this why the results are compared against the control group?
I got genuinely curious. What's your definition of a game, and how does this piece of software not meet that definition? Could you add something to this software so that it becomes a game for you?
> much smaller mac mini

Eh...why make it smaller when you can give it room for extra storage? In the 'old days' I'd have also mentioned giving it room for extra memory too. :(
Lots of biotech-type things are rapidly getting cheaper. Most notably for this purpose, sequencing and DNA synthesis are both getting cheaper at an exponential rate (to the point that there's a term for it -- the Carlson curve -- similar to Moore's law for computing).

A treatment that costs a few million dollars now will cost a few thousand dollars in a decade or two, assuming all costs scale according to the Carlson curve. In practice, this is probably a bad assumption, if nothing else because a hospital bed alone costs a thousand dollars a night or more, but it does seem likely that mRNA-based treatments will become much cheaper to develop over time to the point where they will be cheap enough to be viable by the time they would actually finish passing through the regulatory hurdles.
Hmm, I would have gone from slack to keybase, if keybase weren't bought out.

It seems to me like running a matrix server without open registration would be about all I need and is startup resistant.

But intros understandably don't seem geared to details for migration of simple automated systems. JSON/HTTP is great, but what does sending messages in via API look like given e2e? Is one installing a whole robot framework to replace a simple webhook (similar to how one would be using a whole keybase install for its CLI)?
Coréia DA Morte?
Rude. I would appreciate substantive criticism, especially when I'm linking papers in Nature starting to do exactly what I'm talking about.
> Article is somewhat click bait, it refers to "market share" which I would usually assume to be be the installed base.

Pepsi and Coke have "Market Share"... it doesn't refer to the number of houses with Coke in their fridge. Market share is sales share over a period of time.

This particular sampling is pretty worthless though because measuring "Market Share" over a 2 week timeframe is questionable due to launch windows.
Show HN: Tvaag – World's first Herbal Activewear (My cousin's startup)
This is really interesting! Thanks for sharing. What are the average number of moves per puzzle in the top groups? Do they all end up being 5+ moves or can there be 2800+ puzzles with only 2 or three moves?
I'd rather get the missing ports back and keep the footprint.
Why create a novelty account just for this comment? It's not like you're discussing anything sensitive.
It's one thing to piss on btc on hacker news but would you really put up money shorting it? There are multiple ways to do so.
And I guess even the spelling of the language name is up to debate ?
The Chromium Chronicle: Restricting Target Visibility
Assuming the relationship is not abusive, this is a good deal for young people. It means not having to piss away thousands of dollars a year on rent, which exceeds inflation, and instead saving and or investing the saved money. There are plenty of stories on reddit and here of people living with their parents and doing just fine. The notion that young people must move out is part of the consumerist culture.
Apple is different because it’s a super-vertical. “I love/hate Apple” goes from the physical layer up to the entire platform and ecosystem. Apple is a shared experience.

Nobody gives a hoot about Dell, Lenovo, HP, etc because they are just commodity providers. People do very much care about Microsoft, but they do so on different horizontal layers — finance guys love Excel, IT guys love AD, developers love Visual Studio. But... there is no shared experience.

I think bias is the wrong characterization. End of the day, Apple is very good at communicating their position on things, and they do it across their portfolio. My nine year old son is somehow excited about the M1 chip. Some of the stuff that sounds like bias is really a reflection of people actually knowing what the company is doing.

Other than niche companies like Ferrari, I can’t think of anyone better at marketing and communications than Apple.
I don't see Apple giving users the option to upgrade their Mac Minis to third party storage solutions.
great video on the Halo!
Just to add to my own comment. Why does HN like being so pedantic about the definitions of words? This is an interesting post regarding AI and cellular biochemistry.
Do we really need to add a philosophical debate about the meaning of "solution"? Personally I think anyone who can't add to the discussion about AI and protein folding should just not comment, instead of settled on adding to the what does solution mean "debate". I'd love to see a blanket rule flagging pedantic posts.
This sounds like symbolic regression (where the space of possible equations is usually searched using genetic algorithm).
Also: http://bofh.bjash.com/
Many of the breaking changes had to do with removing accidental features from the constraint file implementation. It seems a lot better to break that now rather than wait for people to accidentally start using and depending on those unintentional implementation quirks.
For anyone looking into alternatives, I am currently compiling a list here [0]. The focus of the research is software that aids with the entire flow of a typical ecologist who wishes to classify/detect different species.

There are a lot of great pieces of software out there for non-technical users.

[0] https://www.notion.so/pgyurov/Camera-Trap-Pipeline-Solution-...
It seems like spending these government funds on creating new challenges like CASP and ImageNet could have an enormous ROI. Don’t let them try to choose the winner, just let them define the game
You can subscribe and cancel immediately after being billed, with the message "I gave as much money as I intended".
Millennials are forced by law to buy over priced healthcare that subsidizes the dying boomer generations. They are forced to pay into social security,but they will likely never see any of the returns.
The vast majority of things published on news websites are not news.

Or at least not news worth reading an article about.
Running a full desktop environment on a Kindle (2019)
Anniversary of Boole’s Laws of Thought [pdf]
> startling rate of women

Most people suck. The silver lining is that you have a great bar for measuring them up against, to find the few that don't, should you decide to get back into the dating game. I'd work that fact in towards the end of a first meetup, since it would save both time and money.
China clears Tesla to sell Shanghai-made Model Y SUVs
For work-home balance, I would say the balance is largely lost, but that as an overall, the experience is still improved. I find it is much easier to work earlier, and later, hours, but to take larger spans of downtime during what was previously our core hours.

Yeah, you need some degree of discipline and that discipline may be to establish fairly fixed working hours. I do up to a point. On the other hand, I don't have any trouble running out to do errands for an hour on the one hand. And checking email or something else relatively quick in the evening on the other.
Ikonli 12.0.0 Released
I know this is highly improbable but I would love, love, love to see a Raspberry Pi with an M1 in it.
>And now Slack are going to sell for $24 billion or more.

I still can't quite grasp these acquisition numbers. At that price you expect Slack to generate 1.5-2 billion in profit per year. That's 4 times their current revenue. When you factor in risk and time value of money it becomes more like 3+ billion per year. I just can't imagine a chat app driving that level of profit.
And that non-mall is exactly like an app developer who has a website for distribution.
My friend, who is working in crystallization lab, has told me that she’s gonna be claiming unemployment soon, and she was only half joking.
Curious, what are the sizes of the training and validation/test datasets (number of structures)?

The proteins are shown on the CASP website [1]. Both the number of residues and number of proteins are bigger than I expected.

[1] https://predictioncenter.org/casp14/targetlist.cgi