skysight-inc/HackerNews huggingface dataset:
> Error handling is hard, Go doesn't hide the complexity, but a lot of other languages try to handwave the complexity away. Either way, programmers are by default lazy, and you end up with "Error 500: connection refused".

Except that (no pun) Go has both exceptions in the forms of panics AND its horrible error interface. I don't like exceptions but I'll take exceptions over Go glorified return codes anytime. No amount of "decorating" that system makes it better. There is nothing to it. Rust is a bit better on that matter BECAUSE Rust has the syntactic sugar to make errors as value painless to deal with. Go doesn't.

Sometimes on your server, you have 15 IO operations to perform, you just want to log on failure and return error 500 to the user. This is the case where go doesn't shine at all, what do you do? aside from being tempted to resort to a GOTO statement?
It's happening way faster than normal for a vaccine, so... yes?
It's also cheap in the US (in the form of HFCS) and smashes that dopamine receptor with a fucking wrecking ball.

Europeans would absolutely eat sugar in the same volumes if it were as cheap there as it is in America. As with most of the cultural differences between the regions, a lot of it comes down to economics: if gas were cheap in Europe, they'd also drive big SUVs; if land were as cheap in Europe, they'd have McMansions; etc.
Molesting? Catcalling? Holy cow, is that cynical. You think the women I met and the friends I made are victims? These are people I still stay in touch with 15 years later. Who said anything about dickpics except for you? The internet has become truly grim if any non-monetized form of looking to hook up or hang out can be considered an act of violence or harassment.
It appears the economy has ascended to the paperclip-maximiser stage where it doesn't actually need people not to be starving.
I don't get the point?
In this case, the GP is implying that their goal is to work ~40 hours and spend ~40 hours with their family, give or take. I think that's quite sustainable.
It's accurate, Wayland is already used in ChromeOS to display Android apps, of course Microsoft is just doing the same.

Remember Wayland is a low-level protocol, it's totally different from X11 stack.
This is a kick in the gut.

I’ve been unemployed 9 monthsc and was denied unemployment. I also made too much for the stimulus.. but hey let’s give my tax dollars to foreigners, because fuck me right?
A Multithreaded Lisp Interpreter with Pattern Programming and Data Structures
Because it's easy. It's like the IRS equivalent of writing speeding tickets to generate revenue. All they have to do is prove you made too much money. They go down a list of income types and see if you had it and how much. The man hour investment is tiny.
One of the lessons I learned from Thinking, Fast and Slow, is that people who present a number as a percent scale can (but might not) have an agenda, as can people who report an absolute magnitude. What I took from this is that if you want to have a rational reaction to the data, you need to have both numbers in mind while deciding how to feel about the situation.

That means 1% aka 70 million dead. Which I interpret as the Uncanny Valley. 70 million is more than enough for vigorous response. But 1% will mean friction from - and for - policy makers.

The problem is, as virologists have told us for decades, Ebola isn't a very effective plague because it's too deadly, too fast. If we don't react to 1% mortality rate, then the end game is we select for viruses that kill 1% of us, and if the mutation rate or family for that virus is large, we get a unique variant every 5-10 years for the rest of time. If the mortality isn't selecting for the same genotype, then that's almost 10% of us overall, death by a dozen cuts.

We have to have protocols in place for reducing R. We have to have the 'pump' primed for putting out fast-track vaccines. We have to have 'red phone' protocols for world leaders to move faster when these situations are developing.

When COVID-25 comes, we'll be either repeating this experience or blaming all of our leaders for learning nothing.
This is precisely the literary slight of hand I was talking about! Similar to Musk's hilarious dismissal of hydrogen technology. Hydrogen will obviously in time become the ideal source of energy for electric aircraft and electric long haul trucks.
Eyes on the prize: my year as a Booker judge
This was more-or-less my thought here too. We have perhaps 20 wild Apple trees growing on our property. We've slowly been culling the less good ones and encouraging the good ones.

I'm a bit skeptical that this will come to anything. Likely the journalist who heard the story doesn't know how common this is?
I have a related question about this. If experimental methods produce results around a score of 90, what is the baseline we are comparing the DeepMind results against? If the experimental error is equal to the observed DeepMind error, how can we say which one is actually more erroneous?
> My selfish concern is then whether or not the vaccine will work for them.

We won't have hard data on that specific question for a very long time, but it's something your/their doctor would be better equipped to make an educated guess about, given the specifics of their situation ("immunosuppressed" can mean a range of things). In some cases, a vaccine might do nothing. In some, it might be actively dangerous. In some, it might have a weaker but still nonzero protective effect. But I wouldn't trust anything you read on HN that tries tell you anything more specific than that.
Ironically, the idea you're pushing, something like "this doesn't really matter, the important thing is the government giving people money, the more the better, who even cares if they're American," precisely represents the best objections to the welfare state. Which are its shoddiness, its lack of administrative rigor, and so on. These objections raise the question: can a welfare state be effective if it's administered so poorly? If the American government is sending money to Swedes, can we trust it to send money to "people who need it"?

Does Sweden send welfare checks to Americans who aren't Swedish citizens? If not, perhaps that partly explains why the Swedes are more comfortable with an expansive welfare state than Americans.
I'm wondering if you could clarify a couple things for me:

1) "Skipping steps" This appears to be doing the opposite. In an old vaccine, you'd just dump a bunch of spike proteins into the system. Here, you're adding the step of making the body produce them. Could you clarify?

2) Why not just produce those spikes in a lab? Is it just much less resource intensive to have the bodies make them?

3) As far as stressing that this doesn't alter DNA: Wouldn't it suffice to say "this does what viruses already do, but less"?
Exactly, from the pictures it appears to be an exposed rock face exposed to daily tropical rains for millennia. Something doesn’t add up.
Show HN: Lightning-Fast Visual Sitemap Tool for Team
Unfortunately, vaccines can't really help immunocompromised people, as their immune system is simply unable to fight off any infection, regardless of whether it recognizes the infection or not (of course, this may be a matter of degrees). That is why, for example, people with advanced AIDS can die from essentially any pathogen.
Deep learning methods are being applied here as well; see for example https://www.biorxiv.org/content/10.1101/2020.07.22.211482v1
Re-use != Recycling
microG is still very useful even if you only use free software apps that don't rely on google APIs: it provides wifi and cell based geolocation
Some people in the article either have no ties to the US at all or have renounced US citizenship, so it _will not_ be corrected next year as they don't file tax returns.

Regardless, this is chump change to the US government, and there are other larger lost amounts of money they should probably worry about anyway.
> This prevents the common Java bug where a checked exception is caught but not handled.

How does the Rust way avoid this? You can just as easily match on an error type with a catch-all case and ignore the error.
What is the process of generating mRNA in vitro at large scale?

Is it as simple as amplifying a DNA template with the spike protein sequence and any necessary promoter sequences then adding some RNA polymerase with free RNA nucleotides?
> "Je n'ai jamais" in French could literally be translated "I not have never"; but in French it's not a double negative, it's just "agreement".

In that particular spot, I'd say a more correct literal translation is "I not have ever." Jamais in the absence of ne tends to be more equivalent to "ever", and I would guess that the etymology of "never" is that it's a contraction of "not ever".

You could also argue that the French grammar isn't a double negative. Ne functions like a linguistic particle that introduces a negative phrase, and then the kind of negation is indicated by the subsequent pas, rien, jamais, etc.

Why I'm bothering to dig into this is, that same "prestige dialect" sort of debate functions differently in French. The ne is disappearing from informal spoken French. The French Academy isn't too happy about this; their official position on the subject (which I'll paraphrase - I'm feeling too lazy to hunt it down and translate it) is that words like pas, rien, and jamais have no negative character of their own, so omitting the ne renders the sentence nonsensical.

(To which I suspect any practicing linguist would respond, "Huh? If it's nonsensical, then how come people who speak this way can understand each other perfectly?" But that kind of distressingly pragmatic attitude is exactly why practicing linguists don't get elected to the Academy. I imagine they'd sooner admit une écrivaine.)
Instagram Scammers Make $10k/Month Using the Dumbest Strategies
The way computer scientists do it, yes, it is. In the CS situation you define an energy function (in this case representing the physical behavior of the protein in water) and find a heuristic to approximate the coordinates of the lowest energy configuration; done, problem solved.

in reality, that's not how it works at all. The energy functions we have are crappy and require too much sampling before we can find the lowest energy configuration. And more importantly, it doesn't look like proteins typically fold to their lowest energy configuration (with the exception of some small fast two state folders), but rather explore a kinetically accessible region around there (or even somewhere else entirely, if the energy cost to transition is too high).

Methods like AF depend heavily on large amount of information correlation from evolutionary data, which has historically been of the highest value for making decisions about protein structure.
Looking forward to Stewart's next attempt at making a game. Third time's the charm!
You might get fewer downvotes if you a) spelled AstraZeneca properly and b) included a link to back up your claim.
Marjomax isn't saying that those with weakened immune responses don't need protection against the virus. They are saying vaccines do not work well in immunosuppressed people, the vaccine will not necessarily provide protection.

Vaccines work by triggering the immune system in the first place. If your immune system is not functioning normally, the vaccine may work differently or not work.

I think it's more complicated than just as a blanket "won't work". But, yeah, more complicated means more complicated -- different vaccines may be infffective, or require a higher dose, or even be harmful to immunosuppressed people. As far as the study, it would probably require a separate study focused on immunocompromised people? The fact that these are new mRNA-style vaccines is possibly relevant, maybe we know even less? Obviously we're in a rush here, there's lots of studies that would be really good to do that haven't been done yet, all that's been done is like a basic "normal people everyone" study. From which immunocompromised people were excluded because they are likely to respond to the vaccine differently, so need a different study design etc.

https://immunisationhandbook.health.gov.au/vaccination-for-s...

(And btw, THIS is what "herd immunity' is about. If enough people are immune (say from a vaccine), then there aren't enough carriers to pass it around the population, so those who AREN'T immune (possibly because they are immunocompromised and the vaccine wouldn't work on them or would be dangerous) still have much reduced chance of getting infected. Because, yeah there are people who can't take vaccines because they would be dangerous or ineffective, but may still be at high risk for complications from the virus)
Agreed, but I trust my email provider to provide push. I would be willing to block all the rest.
I used to love reading the Interzone compilations. I guess some are available online in various places. (One of the stories keeps getting mentioned on HN, and it's pretty good. "Blit": http://www.infinityplus.co.uk/stories/blit.htm )

I also used to enjoy lots of the stories from One Story which was a monthly single short story on Amazon Kindle. I found Caitlin Horrocks' "This is not your city" which is a great compilation.

Bruce Stirling has consistently good short fiction.

For science fiction you sometimes get great one off compilations. "Mirrorshades" is excellent; "Lady Churchill's Rosebud Wristlet" has some great stories.
FCC Chairman Ajit Pai will step down on January 20th
I just want to say thank you for squashfs-tools-ng. For my usecase I had to patch mksquashfs and your tool fits just right. I'm yet to switch however.
I listened to a Joe Rogan that said we’re all space monkey alien-chimp hybrids.
Because it can't.

The bitcoin github and subreddit were taken over by a group of people that just wanted to make a centralized second layer that they could sell. They used (and still use) lies, propaganda and heavy censorship to keep the transaction capacity at only a few per second. Floods of incoming people that had no in depth understanding were and still are unaware that /r/bitcoin was like /r/thedonald - anything (even questions) against the (technically ridiculous) propaganda message that more than a few kilobytes per second in transactions would be a disaster was deleted and the user was banned or shadow banned.

This is not controversial, you can still check out /r/bitcoin

Cryptocurrency in general is an idea whose time has come. Electronic currency that can be used without permission from a third party has many enormous advantages. The original bitcoin chain is nonsense and has been a disaster for the last 7 years.
You would be so disapointed with this OS ... Look for others :)
I'm interested in unpopular opinions here. Do you have a source or details on this?
Perhaps 7k named/ commonly cloned varieties. Every seed grown apple is unique so there are likely hundreds of millions of Apple varieties.
"People are forgetting or never knew that MSDOS had a three letter file extension limit "

/cries in 8.3/
No, they are very crude (but useful!) models of reality. General relativity and quantum electrodynamics are much better corresponding models, respectively, and even those are just approximations.
dekhn, in what way is Art's "understanding of computational biology very limited?"

I'd love to hear more. Specifically, what do you think that computational biology can do that you think Art doesn't understand or credit?
Yes it's not clear is it? And I suspect that it probably isn't clear in the author's mind either.
I expect this to be quickly replicated once published. Training data is public and training compute is not enormous and AlphaFold of 2018 did get replicated.
It would be great if every conversation about regulation on HN wasn't dominated by posts re-litigating if the concept of regulations should exist in the first place.
Whenever you inject foreign biological material, you have to avoid two scenarios:

a) the scenario when the foreign material is immediately degraded by enzymes or other mechanism, before actually accomplishing anything,

b) the scenario when the foreign material causes massive immune reaction in form of inflammation, potentially killing the host.

AFAIK navigating between those two extremes took decades during development of RNA vaccines. But now it seems that we can avoid both.
FYI: Beef tallow leaves a hearty, waxy film all over everything which is difficult to get off of most surfaces and impossible to get out of your furniture.

The taste is incredible and there's really nothing like it, but home cooks looking to experiment would be well advised to do so outside.
If smthg doesn't work on LineageOS, then it certainly will NOT work on /e/ haha
Some feedback that I hope will be helpful:

1. Every sentence should begin with a capital letter. Many sentences in the post do not.

2. No explanation of buffer overflows is complete without an explanation of undefined behaviour in the C and C++ languages.

3. The colour scheme used gives somewhat low contrast to the text. It would also boost readability to use a dark-on-light style rather than light-on-dark, but I think it would be enough to just improve the contrast. I'm not saying it's unreadable or anything, but I think it could be improved.

4. It's annoying to have to horizontally scroll to read the code. I suggest tweaking the second code example so the comment gets its own line and no scroll-bar appears.

5. You say and these are just some of the basic mitigation used in 2020. This is true, but you've missed the big one: modern languages include runtime checks. Might also be worth mentioning that with formal verification frameworks, it's possible to definitively prove the absence of out-of-bounds array accesses.

6. It would be worth explaining the one-past-the-end rule in the C and C++ languages [0] and how these languages consider it an error (i.e. undefined behaviour) to even point to anything beyond that, whether or not you actually dereference the pointer. [0][1]

7. I have to agree with brudgers and jiveturkey that the article is a bit perfunctory. It's quite a deep topic.

[0] https://stackoverflow.com/a/988220/

[1] https://stackoverflow.com/a/41667789/
According to Mitchell and Webb [0], Thomas Hardy wanted to end 'Jude The Obscure' (IIRC) with a sad face smiley just in case people hadn't realised that it was supposed to be a sad novel.

[0] That Mitchell & Webb Sound, Series 5, 2015
NewPipe is awesome... when it works. In my experience of only a few months, "occasional" is an understatement, unfortunately.
The problem with the article is a semantic one but it should not be overlooked.

/e/ “believes” in open source. Less along the lines of “concerns itself with every philosophical checkbox”.

IMO you and the author are filling in the blanks as you wish, landing in the realm of no true Scotsman.

Freedom to create as one would > flocks of sheep.

Personal emotional religion must take a backseat to suggesting folks discuss or use their time otherwise.
It feels a bit like you've assumed that what the IRS is doing is optimal and then working back from that to produce a theory for why they act this way. Considering it is a bureaucracy that is vulnerable to political machinations I don't think the assumption is necessarily valid.
That could exclude people who are the most likely of dying of covid (a severe case of covid doesn't mean dying, for instance I heard an ICU specialist explaining that people who are seriously obese often require ICU treatment but rarely die from it, the people who die usually have serious co-morbidities and an already reduced life expectancy).

But it's kind of secondary anyway. The main goal of the vaccine is to stop the virus from spreading in the population and getting a chance to reach vulnerable people. Even if it were to only protect people who wouldn't die of Covid in the first place, that's the vast majority of the population and enough to significantly reduce the chance of spreading.

At the condition that these studies measure the right thing. If it merely stops the symptoms but doesn't stop the spread of the virus, that may be a problem.
so wrong.

>unlike literally all other commodities on earth, the supply of bitcoin is truly constrained

BTC is not a commodity, so there's no point comparing it to "other" commodities, of which in fact there are true constraints.

> cannot be anymore made in response to demand above the normal rate of inflation.

above? BTC does not track "normal" rate of inflation.

the only reason BTC has value is because it can be swapped for fiat currency. it will never be its own "thing".

> Bitcoin is a social phenomena - no government or company backs it.

This is almost correct. China controls >50% of mining resources, much more in fact. 65%. If and when it suits them, they can ruin it.
I felt exactly the same when Amazon passed over my home city
The problem, generally, is that people are accustomed to certain tastes, and often "healthy" options are overloaded with things to make them taste good. Mayo on salads, tenderstem broccoli roasted with olive oil, corn cobs on a BBQ, etc. - and Indian food, at least as it's known in the West, is no exception. Curries tend to use a lot of ghee or oil, and I'm fairly sure that people skimping on the fat at home is why home recipes (usually from health-conscious/vegetarian/vegan recipe sites) never quite hit the mark. Vegetables can taste great! ...So long as you smother them with the junk that actually gives it the flavor and texture you like.

Think of a dish composed mainly of "vegetables, whole grains, and beans" with minimal carbs and even more minimal butter/oil. What is the recipe? Then, consider if it tastes good - as good or better than similar recipes where more carbs and oil is used. I've been cooking a variety of meat and vegetarian dishes of various cuisines for years and I know of no such dish I'd want to eat with regularity. Brown rice, steamed chicken breast, and cauliflower just doesn't cut it for my palette, and I suspect the same for the majority of people who know how good a Sunday roast or pizza tastes.
CASP is not "the organization that tests protein folding". It's an organization that every two years does a blind prediction and publishes the results (I've competed, some 20 years ago). John's a protein expert, no question about it.
I knew him moderately well back in the day because our advisors moved in similar circles.
Does this give the ability to engineer cures for currently incurable diseases?
Explaining the moves is a very difficult problem, in a sense the "line" (series of moves) the computer recommends as best for both players is the explanation. Translating that information into, say, english, or some sort of useful graphical format, would be a pretty novel feature.
I remember in an interview a developer had asked me to resolve the very same problem. And, I actually at the time never heard of it. He said to me that he knew I didn't have a lot of experience using Docker.
"Experience has shown"?

Did you go create a test case? Or at least link to a specific issue?
Agreed. I think in 2016 Slack just got absorbed in their own thing. Slack is pretty good and has some nice features but not really anything a big Acme corp can't copy. And I'd expect Slack to be another case where 90% of people just use direct & channel messaging, no or few apps, etc. which means the switching costs are very low.

Although on another side, MS Teams is still miles behind Slack. While you can be signed into multiple orgs in Teams, switching orgs literally restarts the program which means that switching from your org to a client's org is super disruptive. If you are in a video call your only option is to open teams in the browser to view another organization.
Also, why is this story on the frontpage? If it wasn't an NPR story would it gain any traction here? Not only is it not newsworthy, it is uninteresting. It's more spam than news.