skysight-inc/HackerNews huggingface dataset:
Your answer isn't exactly wrong, but it's painting with a broad brush. "immunocompromised" is a broad term (even more so than "immunosuppressed"), so there definitely are people who are immunocompromised who could potentially benefit from a vaccine (again, we don't have hard data on that yet for any of the vaccine candidates and won't for a while).
> Just like if you didn't get a stimulus check you deserved because of IRS mixup (like me), you'll just get it as an additional refund on your return next year.

Can you elaborate on this? After months of waiting and calling the IRS with nothing to show for it, I just assumed that I would never see any of that money.
The startup failure of Oomba
I play a lot of online chess, and for the most part I don't believe I've played cheaters simply because I win often enough, and I'm not very good.

I can't rule out that maybe some people check a move or two with an engine in the endgame, but at the same time that just doesn't matter. I don't play chess to win. I play to get better at chess. And that will happen either way.

The learning resources provide by a good online chess site are fantastic today. Puzzles, interactive lessons, instant analysis of your games as soon as they are over. I don't think there's ever been a better time to learn chess.
> They're buying your surplus labor at a very cheap rate.

Have you done the math here? Take the cumulative market cap of YC companies (use a conservative measure). Divide that by the hours worked by founders. Multiply that by founder ownership percentage. I think you'll find that founders are properly incentivized.
Vaccines work by essentially teaching your immune system to recognize a pathogen. If your immune system is in a very weakened state, it likely will not 'learn', and even if it does, it may not be in any condition to fight the infection, even if it recognizes it as such. Of course, things are much more complicated, but in people with severe immuno-deficiency (such as advanced AIDS or people who are actively taking immune suppressants) a vaccine will not have any effect (some kinds of vaccines even risk infecting that person with the disease, though I beleiev this is not the case with any of the Covid19 vaccines).
Customer Success Startup Gainsight Acquired by Vista at $1.1B Price Tag
Any reason you decided on two separate code-bases (iOS & Android) with a small team versus building one in React Native or another hybrid framework. I'd think that the latter would be a better choice but wanted to see what went in to your decision making.
I went for a walk to the town centre during this current "lockdown", and it felt the same as any other year.

Lots of people, festive atmosphere, most shops appeared to be open, coffee shops were open, cafes were open.

The difference was coffee shops and cafes were only doing takeaways and outdoor service. But it's hard to see that from a distance, especially the ones lit and processing orders at the usual counters inside. As a result, people were eating and drinking outside, and it made the seated areas on the streets seem busier than normal.

The pubs were closed, that was the most noticeable thing.

Clothes shops were closed, except M&S which is 80% clothes was open, presumably on the excuse that at the back they sell food. I noticed quite a few other large shops open that seemed "non-essential" to me, but who am I to judge what's essential.

My landlord's property agent was open, which surprised me when they asked me to take a letter there. I asked about that, and they said they are alternating who is in the office each day so there's only half the staff. I'm not convinced they are essential, especially when they seemed to be able to work from home just fine earlier in the year, but it's up to them.

Walking down the street while keeping 2m from other people was difficult even on pedestrianised streets (no vehicles) because of so many people. I didn't see much mask wearing outside - less than in the summer.

It made me quite uncomfortable to be honest; I haven't been out since.

I know that it's more severe in other regions of the UK. But where I live, Oxford, it seemed quite lax. Our case rate here is below average for the country despite a very large number of students.

They must be doing something right, as the figures have started dropping clearly on the charts over the last week. I hope it's because they're being smarter about what to restrict now. Maybe they're actually getting better at this.
They did and have supported Homebrew and others with Apple Silicon. They said so back at the original announcement https://twitter.com/MarkVillacampa/status/127520044676491264...
I think it’s important to remember that one of the goals during this process was speed. The government could surly be more accurate in their distribution of the 1,200$, but it would come at the expense of time. Getting the stimulus check in 2021 would be worth way less.
Molten salt, breeder and Thorium reactors can achieve orders-of-magnitude improvements, and aren't exactly groundbreaking technology. Reprocessing as well. Several examples from decades ago, and new designs in the pipeline. The main problems are politics and lack of funding.
Telegram works for me if you use the Google Store version.
I don't have a smartphone so I do in fact use maps.
One error in 10 thousand is not shoddy at all. I bet it would cost more than $1200 eliminate each of those errors.
The tech might not be out of reach but the talent pool is.

Whether it's good PR or not is to be debated, but it seems that the talent at DeepMind simply can accomplish things other's can't.
That and taking 5 minutes to figure out that it can't possibly do what you told it to (except, of course, it can).
Maybe, but the counter is enough money is at play to create a successful competitor. Someone doing a smart phone with 1/10th the penetration of Android is somewhat significant and not to be ignored. (in absolute numbers that is more than the number of Mac users vs Windows users)
Domains are archive.today
archive.is
archive.fo
archive.li
archive.vn
archive.md
archive.ph

At least one typically works.

List: https://en.wikipedia.org/wiki/Archive.today

Cloudflare is in a grudge match with archive.today:

https://community.cloudflare.com/t/archive-is-error-1001/182...
This method has been in development since 1978 (when then-young Hungarian scientist Katalin Karikó started playing with mRNA in her lab in Szolnok) until today. Hundreds of mice died during the search for bugs before anyone dared to inject a human subject.

It cannot be ruled out that the whole concept of RNA vaccines still has bugs, but it is nowhere near "it compiles, ship it now!" software betas. The process is much more risk-averse.
Why everyone needs to learn social engineering
Love it. I do think that the "learn" section should always be open. For me (FF) after the first challenge it's closed by default which leaves just a command line and no clear direction.
Sound like a new bubble?
For example it does not allow apps running on background (something that causes whatsapp web to not work at all).
Element.ai Acquired by Service Now
Yeah, it was a big slap in the face. But, to be fair, most of the scientific and technological advances (sequencing efforts, structural genomics projects, etc.) that generated the data used by DeepMind came from academia and, to a lesser extent, the pharma industry.
fold.it was always more geared towards being edutainment than actually contributing solutions. Of the ~20 publications made related to fold.it over a decade, ~5 of them seem to have contributed to solving structures, while the rest of them are about the game itself.
small surprises :-)
https://octopus.do/sitemap/blackfriday
Looks like it won't break the $20k threshold again. Back down it goes... I knew this was about to happen again when, just like last time, I heard regular "non-techy" people talk about it at work.
Most of DRAM latency is actually not DRAM itself, but CPU, and its controller.

DRAM always been at aroun 10-20ns of latency. PCB traces themselves add a maximum of 6ns roundtrip.

DDR PHYs on both sides do huge amounts of analog, and digital signal conditioning. Refresh system add random latency if you hit a refresh cycle. Prefetch-burst mechanism also adds limits of your effective random access times.

This is why HBM may well beat regular DDR on real world latencies.
It's intermittent, hence use of alts, which also fail intermittently....
My hypothesis is that all the Tech People turned into Ponzi schemes (er, sorry, info products) after trying showing their tech products here on HN and getting roasted in the comments.
How will this get into the hands of those who could use it?
I was thinking that tech companies are in the San Francisco area because that's where a lot of tech talent is found, and tech talent is found there because tech companies are there.

Is there anything more to it than that?

I'm happy to see tech spread out a bit. The absurd housing prices in San Francisco aren't healthy for either the tech companies nor the non-tech neighbors.
I personally don't hate Mastodon but I've never found an instance that clicked for me. Feels like a more confusing Twitter but happy to be re-educated
To me, what he seems to enjoy most isn't the act of making money itself, but the act of getting better at making money. The great thing about having "making money" as your hobby is that the feedback for performing competently is very clear: if you're getting better, your numbers will go up.

The problem with this hobby, and I suspect this is what the author may be sensing, is that the motivation is extrinsic. The rewards come from outside himself. He is forever reliant on an external force for his own satisfaction.

I think the best fit for this guy would be a hobby that is, like his current hobby, based around the mastery of a skill -- something he can practice and see himself getting better at -- but which doesn't require an external rewards system.

The good news is that almost any creative hobby can satisfy these requirements. As for which one to pick? I've found that looking back to one's childhood can be immensely helpful. What amazed you as a kid? What's something you really tried to be good at, but you couldn't quite make it work? It doesn't have to feel like passion yet. It just needs to be a seed. A tiny hint at an activity you might find satisfying eventually. If you give yourself enough time and room to play with that thing, you may get to experience that passion taking hold.
> the idea you're pushing, something like "this doesn't really matter, the important thing is the government giving people money, the more the better, who even cares if they're American,"

I'm almost unsure how to reply because you seem to ignore the central point of the comment you're replying to. Your characterization omits the most salient point: That it had to be done fast. I don't see how the tradeoffs in emergency distribution of funds are in any way indicative of whether you can trust welfare states to be administered properly or not. The comment was precisely about "lack of administrative rigor" being warranted in favor of preventing greater harm.

> Does Sweden send welfare checks to Americans who aren't Swedish citizens? If not, perhaps that partly explains why the Swedes are more comfortable with an expansive welfare state than Americans.

I don't understand how this point relates to the general value of welfare systems that you are discussing. Are you saying an American welfare system has to be inherently less reliable? Or that there are more Americans than Swedes so statistically Sweden will receive more accidental checks from America than the reverse? Could you elaborate?
Afaik Yalp store isn't maintained anymore. Maybe try Aurora Store instead.
Acid: My Personal “C” Change
I assumed you weren't being sarcastic.

Comments in general are pseudo-dialog. Whereas in real life, we stumble over our words and can't edit, in well-policed comment sections with sincere posters, we can all contribute to a Sorkian drama.
I got internal server error when trying to locate IP
This is still for proteins that fold without chaperons, but I guess it does cover a lot.
>The set of all proteins which can potentially be expressed is known.

Sure, "known", but it's on the order of 20^10000. It won't fit in the entire visible volume of the universe.
I suspect people who grow up in (basically) a socialist country like Germany, France, Scandinavia etc will have far less impetus to 'get rich'.

If you feel secure in being able to maintain an income where you can enjoy both the basic and leisurely aspects of life. That you won't be made bankrupt by illness, or by unfair illegal/legal proceedings. In these circumstances the drive to sit on top of 2.5M to feel relaxed about your financial situation will likely fade away.
and we've wasted so much of our uranium making bombs that can never be used as fuel. There is research in trying to use highly enriched uranium as a fuel source, but I doubt that will ever be a safe reality.
Use onnxtools at https://github.com/onnx/onnxmltools to convert your model from Core ML to ONNX. You'll then be able to use it elsewhere.
It has always been the preference of the "progressive" (Peskin) wing of SF conservatives to halt population growth by crashing the economy. People who inherit giant Mexican land grant fortunes attend Little Ivies back east, come to SF and become "tenants' rights activists" and spend their lives vilifying people who ride buses to work for a paycheck as "gentrifiers". These people are now psyched that they don't have to share the city with people who have jobs.
I developed the Exacycle system at Google and used it to publish my work (I wrote that blog entry): https://ai.googleblog.com/2013/12/groundbreaking-simulations...

we offered the service for free to Genentech since I used to work there and knew they could probably use it to get some good publications.

We didn't open source the distributed computing framework, but the underlying technology (Folding@Home) is based on gromacs, which is open source. It's the scale at which it ran, and the processing pipeline for filtering the results that had the real value.
> It's always going to be cheaper to pour end of life cells into a remanufacturing process than to extract raw lithium from brine ponds, so it makes economic sense to do the R&D to do so.

This is a major point to assume away.
It seems like a lot until you consider that it has been surpassed by many other investments in terms of gains such as Tesla, Paypal, Palantir stock and others. The days of Bitcoin going up 10-50x in a year are over, but still interesting to see what happens next. I think increasing regulation and the use of blacklists and 'coin tainting' erode whatever use bitcoin has though, as there will be no fungibility. This makes bitcoin worse than even cash in terms of being usable and censorship-resistant.
> Which are its shoddiness:

I mean, they sent what, $34m overseas erroneously of $2T?

Doing some quick napkin math, for every $1,000,000 spent, $10 accidentally went overseas?

Why does this seem poor to you? That seems like less than a rounding error in a rounding error....
> Does Sweden send welfare checks to Americans who aren't Swedish citizens?

Generally, yes, if they worked for some time in Sweden. There is probably a non-zero error rate associated with that too. It's not like the gov't is sending checks to random Swedes - they were sent based on available sufficient tax criteria not originally intended to be used for entitlement distribution.

I do suspect most countries wouldn't have a problem on the scale the US might because a) they have larger, simpler entitlement programs (qualifications tend to be based on a a small number of straightforward residency classes), and b) they do not generally process any tax paperwork from non-residents. It is the US's stinginess and paradoxical fear of inefficiency that hurts it here.
Case preview: Justices to consider breadth of federal computer fraud statute
12-13 years ago in a classroom the professor for my intro to bioinformatics class said if you were to solve this problem, you would win a Nobel prize. Congrats to the team! What an achievement.
Issac Asimov - The Last Question

David Foster Wallace - Incarnations of Burned Children
> "The Thirties had seen the first generation of American industrial designers; until the Thirties, all pencil sharpeners had looked like pencil sharpeners—your basic Victorian mechanism, perhaps with a curlicue of decorative trim. After the advent of the designers, some pencil sharpeners looked as though they’d been put together in wind tunnels."

A leading figure of this design movement was French-born Raymond Loewy:

https://www.smithsonianmag.com/innovation/meet-product-desig...

Gibson writes that "most successful American designers had been recruited from the ranks of Broadway theater designers", but this is not the case with Loewy.

He had an interesting life and career, and his autobiography "Never Leave Well Enough Alone" is a great read. Sadly it seems to be out of print in English.
1) Yeah, besides picking the step of manufacturing virus parts, I agree, this is going a step back in the virus's life cycle.

2) It's hard to produce proteins in the lab. Our own cells are pro at it, though, including all of the post-translational modifications (like attaching sugars and careful protein folding) that can make all the difference.

3) Pretty much. Since it's just one gene being introduced, it will not produce new virions, only the spike protein that our immune system needs to recognize.

Source: Am microbiologists, although not a virologist.
I think GP intended and you have to read it in the context of, does it grow your business? The school of thought is anything that is not growing your business is inane, especially time consuming tasks, like child care. It's not an indictment on the importance of said task.
The beta test (clinical trials) are long over, they had it months ago.
I suspect that thy learned these things, but it didn't stick. From memory of 2018/2019 things that the younger colleagues didn't know (or didn't know well enough to get without prompting):

- When to use CFG versus regex for parsing. Many inputs could be parsed with regexes if you made certain assumptions and got lucky. But CFGs were much easier for some.

- Shunting-yard algorithm. This came up, I think, in 2018.

- Using fast/slow to detect cycles and cycle length (one step at a time versus two, when they collide you can determine that there is a cycle and then determine how long the cycle is). Most used a hash table/map but this was not effective (due to RAM requirements) for some very large inputs. This actually comes up a few times. Variants of game of life, or just numeric processes.

- Multi-threading. It was very useful to implement the intcode VM using threads in 2019. Everyone who tried to juggle state and run multiple VMs at a time struggled when we later had to have a large number of VMs communicating with each other.

- Maybe not CS proper, but typically covered as part of a CS curriculum in a discrete math course. Several times problems related to modular arithmetic and permutations came up. If you understood them, the problem was tractable. If not, you struggled and maybe solved it but it wasn't efficient.

- Various graph and search algorithms. Particularly A* and Dijkstra's. Looking back, it seems there were a couple maze ones in 2019 and several more maze/path finding ones in 2018.

- Sorting/ordering of graph nodes, specifically topological sort. If you know what it is, it makes several of the problems much simpler over the years. I think it was specifically used in 2018.
Everything can be broken down to simple easy to understand little bits. The complexity comes from there being many, many of these little bits.
When this came out, it was a repudiation of the caricatured ideals of the early SF of the 1930s - stuff that was fifty-one years old at the time. This was the dream of the future everyone had, once.

This story is thirty-nine years old now. Gibson's Neuromancer is only three years younger, and it feels as laughably innocent to our future-dwelling eyes as anything he was making fun of in this story.

Time makes fools of us all.
Yeah they're like baby Oracle.
tableau is still pretty good, but their prices are out of touch
Nobody forces you to use those services though.
Is Big Sur’s system volume sealed?
Flutter vs. React Native – A detailed evaluation
That's highly debatable. Also, obviously 'most' begs the question 'most by what?' if it's just by number, then that seems unlikely but possible. But most by weight, volume, or, more importantly, functionality - not really, that's definitely human cells.
CASP typically works this way: one person "wins" by getting a slightly higher score than everybody else. Two years later, the top teams have all duplicated the previous winner's tech, and two years after that, there's a github you can download and run on your GPU to reproduce everything.
>If someone makes it clear they are interessted in dating, then yes, go for it.

But showing clear signs of interests is exactly what you seem to be against. If no one is allowed to start an interaction then how is it supposed to start?

>The victims here are mainly the people who are forced to cope with that crap, but never asked for it, and don't wanna date any of those people for whatever reason.

It seems to me like a simple fix; when someone approaches you you tell them "sorry not my type/interested/looking."

Or just block messages from people you don't know.

I'm not keen to destroy all social interactions for the sake of the people who cannot handle them.

> Yet we still don't have filters for dickpics and sexual harrasment.

I see where you're coming from, but I disagree with your solution, which is to just prevent any interaction that's sexual in nature (although dickpics are not the same thing as what op was suggesting).
Patreon: Marcan Is Creating Linux for Apple Silicon Macs
Maybe combine with https://news.ycombinator.com/item?id=25254772 ?
ImageNet is a competition and a dataset, AlphaFold is a neural network.
think that post got removed from reddit, this tweet would give more context: https://twitter.com/Felix_Josemon/status/1333447977025695747...
Heroku has hardly done anything since their acquistion, maybe all the team's effort got redirected to force.com
I still only have $11 of BTC :(
Poetry is by no means the only option for this.

Lots of people like pip-tools, it would feel a lot more lightweight and closer to pip than Poetry does.

Pipenv exists but... steer clear for a multitude of reasons.

Personally I like that Poetry centers itself around the pyproject.toml standard. I also think that its usability and the enthusiasm of both the maintainers of the users is going to really carry it more into the Python mainstream in the coming years.
I’ve been calorie counting for many years and work out an hour per day on average. My father insists that I’m “skinny” (not fat) because I was “born that way” and “lucky”

Many people don’t like to attribute their failure, or others success, to personal responsibility.
If I understand it correctly, the "Open Knowledge Foundation Deutschland" has received roughly $3 mio in government funding annually to promote "Cyber sovereignty". You are correct that the individual grant to microG was probably capped at €47k, but since they also sent out grant money to

https://www.qubes-os.org/

https://openwrt.org/

https://bitmask.net/

https://github.com/juga0/dhcpcanon

https://taler.net/en/index.html

https://identity-stick.github.io/

https://github.com/lernapparat/lotranslate

https://sbws.readthedocs.io/en/latest/

https://leap.se/

https://robur.io/Our%20Work/Projects#OpenVPN

it looks like a coordinated campaign to me. The list includes a privacy-conscious OS, some VPNs, some Tor services, and a Cloud-free translation system for LibreOffice. microG very much fits into that list of tools to avoid Google's spying eye.