skysight-inc/HackerNews huggingface dataset:
This is a reddit-grade defense and strikes me as a weird rationalization. Are you suggesting that the Bay Area is destined to be some insulated District 1 that perpetually laughs at quality of life, economics, market forces etc?

In any case there's nothing to debate, the exodus has been happening for years and has only been accelerated and highlighted by the Covid news cycle.
No, it's not. It uses Haskell's data types but it's explicitly not about Haskell's data types.

It also explicitly addresses two definitions of "object" so as to constrain vagueness.
No, because they're completely independent; there's an entire industry of claiming that stuff is a hoax. Anyone paying attention to those countries will notice that they generally had high rates of mask wearing and generally took it seriously after the previous SARS.

Most of the COVID contrarianism is a product of the political system, not of reality.
>Does not going to indoor weddings decrease your chance of infection? Yes, obviously

Sure,but at the same not having indoor weeding also has its disadvantages.

The question is, is it worth the risk of going to indoor weeding? At least for me its obviously yes.

>Do masks work?

the article pointed out research paper that says there is no strong evidence that mask help.

>Do masks harm?

For some, yes, for start it can be uncomfortable to wear, it can even be more uncomfortable when exercising or in hot weather.

Not to mention you lose clue from people facial expressions.
> While we get the insight of being able to predict some structures we don't get the insight of why things are happening the way they are.

This isn't something specific to AI, but science itself. We know the value of C, but now why the value is C, sure we can point to something like the Lorentz transformation, but we can't and probably won't even be able to explain why it has these particular constants, we just know that we can measure them and they are this.

Science isn't in the business of answering why. A successful scientific theory does two things, A) Makes useful predictions, B) Is correct in its predictions. It'd be wrong to call a NN a scientific theory, but it certainly does make predictions and as these results show, it is
correct in its predictions.

Sometime soon, humanity is going to have to come to terms that we will soon (or perhaps already have) enter an age where mankind is not the only source of new knowledge. AI-derived knowledge will only increase as the future unfolds and the analysis of such knowledge will likely become it's own branch of study itself.
Kısa Link Oluştur – Link Kısaltma Servisi
HN pushes back on hype and because there's generally too much hype in announcements.
this page is unreadable on android, the text is positioned off-screen
It’s so sad to watch the success of Apple bring upon the impending death of open source.
I have never wished my laptop had cellular connectivity, I have always used a portable hotspot for that.
Do you have evidence for that?

The stats I've seen seem to indicate that COVID has behaved (in terms of waning) more seasonally than in response to lockdowns.

For example Sweden, who didn't have lockdowns anything like what we've seen in other countries, have a curve[1] that tapered off too. At deaths per capita, they're lower than UK, Spain, Italy, Belgium, and many more.

[1] http://91-divoc.com/pages/covid-visualization/
> it is very unclear whether, in the long run, more lives will be lost to the costs of a severe lockdown than saved by it

I have yet to see data that shows any evidence of this theory. If you are aware of any existing data that points to this conclusion, I'd love to see it.
Can you easily drop to a command line and just rsync your data to a remote host ?

... asking for a friend ...
"but you'll get shouted out of the room if you bring up that position even as a hypothetical."
Hardly worth not doing it. The stuff depreciates far slower.

I’ve been using an M1 mini as my desktop for over a week now and am impressed.
> the M1 is fast isn’t due to technical tricks, but due to Apple throwing a lot of hardware at the problem.

Apple threw more hardware at the problem and they lowered the frequency.

By lowering the frequency relative to AMD/Intel parts, they get two great advantages. 1) they use significantly less power and 2) they can do more work per cycle, making use of all of that extra hardware.
Thanks a lot for the feedback! I know it’s not always easy to share, but definitely appreciate it. Maybe we can add an opt-in for our analytics: we mostly use them to understand what we should build next (or measure when we do A/B tests in the app), as well as be able to help when people get in touch with a coach via Intercom. All of that can/should be optional though, so I’ll bring that to our board and see if we can do something there.

Also, there’s no harm at all in caring about privacy, rather the opposite, so your opinion is 100% valid!
It kinda seems like Romain used all technology available to save his live.

To be able to hit guardrail at 220km/h which dissipated the energy without killing the driver of deceleration, have the car ripped apart on purpose, have the flimsy compartment keep its integrity without anything penetrating the driver, have fuel contained and only a little bit of it spill, have the suit save him from almost all of burns.
> In 2017, Pai voted with his fellow Republican commissioners to remove rules that prohibited internet providers from blocking or slowing traffic to particular sites and offering higher speed “lanes” at higher prices. Many major internet providers have not yet taken advantage of that rule change, however.

It seems likely that this is because they consider the looser regulations likely to be overturned in Biden's presidency, not because they don't actually want to make changes they spent millions lobbying for the right to make.
Didn't the author address that?

> In effect, the major selling point of the “object”-style design here is also a major downside: you don't have guarantees about the specific representation of data, which means your programs can easily mix-and-match different representations, but it also means that your program can't make use of representation-specific knowledge in ways that are advantageous.

> There's another major concern as well, and that's that the specific choice of “object” representation can make a big difference in terms of what operations you can and cannot support.
Exactly. All we need to do is get the "days since somebody last infected somebody" counter up to 14.
Technological Convergence
Yes, a thousand times this. I've been following the sport for a little more than 2 decades, I was a kid when Ratzenberger and Senna died (and he was a hero for my dad and for my home country).

Watching this live I couldn't believe it, I audibly gasped when I saw a fireball in F1 in 2020.

More impressive is how the thorough enactment of safety rules really played all out in Romain's accident like you mentioned. It's easy to get complacent after a while without major accidents, in most industries, it was really heartwarming seeing how the preparation of years paid off to save a life.
Note that Bell Labs is another example of the corporate monopoly research lab producing things that others couldn't / didn't.
> I blame technology for our current predicament. If we didn't have computers and a global internet, there's no way we would be shutting down everything.

My take on this is that, without the internet, we would (1) either still choose to lock down and cause much greater economic harm[^1], or (2) not choose to lock down and lose more lives. I'm not disagreeing with the fact that we still need to perform a cost–benefit analysis before going into lockdowns. But the internet has lowered the "cost" part of this analysis, by allowing most people to continue to work during lockdowns.

[^1] Note that during the 1918 Spanish flu epidemic, there were also lockdowns: https://www.nationalgeographic.com/history/2020/03/how-citie...
Yes, been doing that for about 30 years. Now and then you just have to take a leap. I usually buy what was the best last year at a bargain price instead.
> It is possible to write instructions that would be 16 or more bytes, but the micro architecture will “throw” an illegal instruction exception if it encounters one. Intel doesn’t say why there’s a limit

I remember noticing on the 80286 that you could in theory have an arbitrarily long instruction, and that with the right prefixes or instructions interrupts would be disabled while the instruction was read.

I wondered what would happen if you filled an entire segment with a single repeated prefix, but never got a chance to try it. Would it wrap during decoding, treating it as an infinite length instruction and thereby lock up the system?

My guess is that implementations impose a limit to preclude any such shenanigans.
The original clacks! Terry Pratchett always finds ways to jump up when interesting factoids surface.

Thanks for this tech history lesson, it might explain something about 19th century France that I didn't learn in (French) school.
The problem is that in reality, paying more taxes just creates more problems.
Ah, we do have a general purpose importer from sqlite lurking but not published, I'll bump its priority. In the meantime, you can use the hosted or local rest api from python or javascript to generate a grist spreadsheet https://support.getgrist.com/rest-api/. On the backend, for serving individual user spreadsheets, we use node/express workers connecting to a pool of sqlite files, persisted via the sqlite backup api https://sqlite.org/backup.html https://github.com/mapbox/node-sqlite3/pull/1116. If you want to dig in, you could poke around at https://github.com/gristlabs/grist-core
so did original Macintosh, and ZX Spectrum. Unified memory is not a good thing, makes the CPU and GPU fight for access.
It may not list it as an alternative English spelling, but the page for the main dialect of Frisian does indicate that the language's own name for itself is spelled with a Y.

https://en.wikipedia.org/wiki/West_Frisian_language
We have laws against that, but not much well enforced. Most of domestic violence happen in private without witness. Even if aggressor is removed temporary, they live together so it is easy to retaliate after. Plus, it is shameful to be victim of domestic abuse. So, reports are few and come in too late and it is hard to prove they are true.

Plus, the enforcement is hard. And even harder since domestic violence rates among cops are higher then those of general population.

> I’m saying the expectation going into a marriage should be that one partner is dominant so there are no power struggles much like a hierarchy in a company.

Aaaand this is literally what leads to abuse. See, the perfect compliance is not possible nor actually human. The one dominator is bound to do dumb or egoistic decisions here and there. Or decisions that ignore needs of partner due to ignorance. With partner being submissive and not providing feedback, dominating person is bound to become worst and worst.

Plus, actual humans have real need for own agency. And when that agency manifests, again, the one who feels entitled to rule it all becomes abusive.
The EU is a whole different level of incompetent, but attributing that to regulation alone would be misleading. For one, Europe is much denser than the US. Naturally net loads would be high if everyone were forced into a lock down uniformly, with armed patrols and the like.
Let me abuse pythonic values:

IMHO, minimum sentencing requirements and a rigid adherence to stare decisis is harmful.[1]

On the other hand, it is helpful to have a reasonable expectation for how things are going to turn out.[2]

I don't have the time to compare and contrast "casuistry" with legal realism, but my hunch is it would end up with the same result: judges figure out how they want to rule and then pick and choose what law to use to get there.

[1] PEP 8 (Quoting Ralph Waldo Emerson), "A Foolish Consistency is the Hobgoblin of Little Minds".

[2] PEP 20, "There should be one-- and preferably only one --obvious way to do it."
Oh, I see! Yes, an intrachain alignment of an artificial sequence does not by itself give any information about co-evolution, especially since you don't know whether your protein is actually folding. To assess co-evolution you need a multiple sequence alignment between protein homologs containing correlated mutations.

> I understand that similar sequences may fold similarly (although as length increases, I highly doubt it, but IDK).

As long as the sequence similarity is kept between those sequences, length is not an issue.

> Co-evolution suggests that aligned sub-sequences are also proximal

What do you mean by "proximal"? Close in space, or similar in structure?
Rhetorical Questions (2017)
Literally every media outlet I have encountered has published extensive coverage of the wider economic, health, social and political impact of the virus itself and the response to it.
Very nice. I like to try doing these in a different language each year. Last year went very well with F#, let's see how this year goes with Haskell.
Yes, again, I'm not disagreeing with any of what you're saying.

But for those barely clinging on to society, and those who haven't had the chance to accumulate real wealth, life is still pretty hard. Or, at least, a millennial may find life seems hard in comparison with the Baby Boomer generation. Many Baby Boomers lived stable, tracked lives in the postwar economy, and have now accumulated vast generational wealth.

If there's a generation that grew up in a bubble, it's the Baby Boomers, and you'll see this typified by the "in my day, I worked my way through college and bought a house while working my job at the coffee shop" sentiment. Millennial and younger generations just don't have this chance at stability and building wealth at a young age.

Also, drug addiction, lack of any care for mental illness (even sanatoriums), and homelessness of the kind we see now are unique problems that started around the same time as the "war on drugs."
>It's very hard to dissent against the current narrative because any dissent can easily be framed as "killing people".

Every dissent winds up getting framed this way. The numbers don't matter. The way you win is by having "your side" be the side who's policy kills people less directly. When you take it to extremes like "make everyone do backbreaking labor and all the health problems that comes with that to save a few dozen kids with cancer" the absurdity becomes obvious. It's maddening but this is the nature of a lot of arguments we have in society today. For example you have Safety Sally wanting to do something that will crush an industry in order to save a few dozen workplace injuries. How many years of life will be lost from all those people's reduced standard of living? Hard to tell. But Safety Sally always wins because she can argue that anyone arguing against her policy is killing people more directly, numbers be damned. Sometimes (e.g. coal industry) the numbers do work out in her favor. Often times it's hard to tell and then you get into arguments about who's analysis is more accurate
I just switched to pipes, ugh
Chicago is also bankrupt like the entire state of Illinois.
Taleb has been going pretty hard all week on how that study doesn't demonstrate what certain people really, really want it to demonstrate: https://fooledbyrandomnessdotcom.wordpress.com/2020/11/25/hy...

Check out his Twitter feed for more.
They are saved to our database. At some point we hope to integrate with other applications so you can process that info as you see fit. This is the MVP, hoping to get more feedback on what potential users would see as beneficial to them. Thanks for the comment!
That is a perfectly reasonable approach to that answer indeed. Registers do hold state and saving restoring them is burden of program code (user, compiler, lib, os).

Contrast this with a hypothetical cpu that has only one register "base" and allows to address 32 words after the address at that base register. i.e. things like arithmetic instructions would have 5 bits to address operands which will be interpreters as base+8*n. To make things even more interesting this architecture's instruction pointer lives at base+0.

Such an architecture would have one register under your metric (as only one register needs to be saved/restored to context switch an entire "register file").

However, implementations (microarchitecture) could actually shadow that memory range into hardware registers, and page in/out the whole register bank upon writes of the base register (effectively performing a hardware assisted context switch; hello TSS).

However, since each instruction in this hypothetical ISA must have enough space in the encoding to address these operands, for all intents and purposes this architecture would have 32 registers.

Deciding instructions, addressing operands, dealing with consequences of code density (icache misses), ... are all way more frequent events than context switches.

Hence I do agree with TFA that operand encoding should be the default metric to count registers. And this also includes sub/overlapping registers, if they are independently addressed.
Barely related, when I was a kid we used to share Earthlink accounts ("ELNs"). We'd dial into those, then login to AOL, instead of dialing it directly. This allowed for some nice things, like getting "punted" didn't ruin your downloads and make you start over...if you weren't using a download manager.

Those were some fun times as a teenager.
ah! thank you
I think the fact that so many comedians are complaining should be seen as a huge early warning sign.

They're canaries in coal mines.
Well, at least Homebrew are claiming that "There won’t be any support for native ARM Homebrew installations for months to come." (https://github.com/Homebrew/brew/issues/7857) so if you rely on a large variety of open source and closed source tools that might be a problem.
In short - certain ones, yes. This should be one step (that was a bottleneck) in helping a company with a fixed budget do an order or magnitude more 'experiments' with the same amount of resources. Lab resources are expensive and fixed, so if you can pre-compute what you need, you can get right to the more powerful results.

We design proteins for immunotherapies - this kind of thing would help us more rapidly design our proteins (and more efficiently use our wet-lab resources to speed existing projects). For others, some drugs are hard build without knowing how they will interact - this could both provide new 'targets' to go after, but also might help prevent projects that would otherwise accidentally target an important protein.
I'm just asking a followup question. Does that read as shouting to you?
No they (Chicago) are not paying for them. They have the obligations, but they are underfunded. That's their big problem.
Now you mix User-space programs with kernels, we talked about Operating-system (Unix), if you see it like that Windows or Linux is the most modern OS, because most Software.

>explored the idea of Java based kernel drivers

They even made a Java OS a Browser and a Chip, we all know what a stupid decision that was, you could have say ZFS which is against the unix philosophy (one program one job) but you forgot that i think.

>Irix had Inventor.

Windows had paint, and Mac the almighty HyperCard...but that's NOT the Operating-system nor does it make any difference Unix-wise.

>NeXT had the mach kernel, drivers written in Objective-C

Ahh, now you bring the kernel argument i already brought, yeah drivers written in the beloved Objective-C (is that a feature or a User-space thing?)...you know Multics was made with EPL waaay earlier.

They are pure and certified Unixes (not NeXT, but MacOS X is/was), based on Unix ideas..basta.
If a reader were skimming the article, they might have missed that the 172 decibel "reading" was measured at a gasworks 100 miles from the eruption!
I've written a benchmark to measure such thins and from what I can tell.

Each fast core has a L1D of 128KB.

The fast cores have a cluster with 12MB, cache misses to to main memory.

The slow cores have a 4MB L2.

The cache misses from the fast L2 can't quite saturate the main memory systems (I believe it's 8 channels of 16 bits). So when all cores are busy you keep 12MB of L2 for fast, 4MB of L2 for the slow cores, and end up getting better throughput from the memory system since you are keeping all 8 channels busy.
You Likely Don't Need a $2000 Server for Your Home
Agree this is great to hear, but the fact that they had X-ray diffraction data indicates this protein was indeed crystallizable no?

Though the next paragraph in the article shows that DeepMind is indeed working on mapping out reliability:

"Demis Hassabis, DeepMind’s co-founder and chief executive, says that the company plans to make AlphaFold useful so other scientists can employ it. (It previously published enough details about the first version of AlphaFold for other scientists to replicate the approach.) It can take AlphaFold days to come up with a predicted structure, which includes estimates on the reliability of different regions of the protein. “We’re just starting to understand what biologists would want,” adds Hassabis, who sees drug discovery and protein design as potential applications."
> To your main points, they have yet to fully utilize advanced packaging (TSMC 3D for example) to get much more RAM in the SOC.

The big problem is as you get larger and larger amounts of RAM, the demand drops precariously. The number of people who need 16GB of RAM? Very large. The number who need 32GB is at least an order of magnitude smaller. The number who need 64GB another order of magnitude smaller. The number who need 256GB of RAM or more is likely in the low thousands or even hundreds.

Making a custom package for those kind of numbers becomes prohibitively expensive.

> I don't mean to pick on you as you're not alone in what is a very natural skepticism. However, it is somewhat amusing to watch the comments about the M1 over time. When Apple announced the M1 based products many critics were crying impossible, faked, rigged benchmarks, etc

I've figured from the start that Apple wouldn't make this transition unless there were a significant win here. In my above comment, I think I made it quite clear that I expect Apple's upcoming CPUs to outperform Intel.

I'm just not as certain the delta between Apple's top end CPUs and Intel/ AMD will be as great as the delta between the M1 and the Intel CPU it replaced. So for example, the M series chip might be 20-30% faster than the Intel in the 16" MacBook Pro, not double the performance as it was in the MacBook Air.
They do something similar for ‘loops’. CPU doesn’t decode same instructions over and over again, just using them from ‘decoded instruction cache’ which has capacity around 1500 bytes.
Very frequently you are not a person that people won't mind you don't respond to them.

I need to read every non-spam email I receive and give a response if only to keep people in my network.
As Anthony Fauci already pointed, one study can be both peer reviewed and be wrong.
I wonder if in 3 or 4 years there will be a new chipmaker startup which offers CPUs to the market similar to the M1. If Intel or AMD won't do it that is.
"But I'm also willing to bet you're reading this on a phone."

How much are you willing to bet?

What is interesting about this website is that it isn't accessible via https, archive.org nor search engine cache.

These increasingly rare holdout sites cause me to take note of just how much I have had to change the software and configurations I use in order to accomodate the rise of manadatory TLS use (at least on sites posted to HN).
What you're describing entrepreneurship. I'd imagine pretty much every entrepreneur realizes they have an extremely low probability of success, but some people prefer the thrill of the hunt to the feeling of being a cog in the wheel job at large corporation.