skysight-inc/HackerNews huggingface dataset:
Back-of-envelope numbers: US GDP per capita * US life expectancy is about 5 million dollars. Healthcare is maybe 18% of GPD and climbing, call it a million a person and rising. A majority (but not a huge one) is government spending.

I don't exactly know the breakdown, but it must skew towards the old & sick -- like cancer patients. It's not inconceivable that million-dollar cancer treatments could become widespread.
A very debatable level of "successful" on that. It shipped in a product, yes, but it wasn't very good either. It ran ARM code, but not very well, and was a horrible nightmare to work on. The JIT'd aspect completely breaks profilers. ie, what do you mean this simple field access took 20ms?? Oh, because the CPU wasn't running my code, it just silently went out to lunch to JIT some random shit, cool, thanks. There's then also the questionable security design of a globally read/write/executable chunk of memory where security is "enforced" by the JIT which is a complex bit of microcode, totally nothing can go wrong there...

It's only noteworthy "feature" was that it was able to ship ARMv8 support before ARM had a proper ARMv8 CPU design. Time to market for a new ISA was fast, but that's about it.
> I think (from my parents and in-laws) that immunosuppression is normally associated with current cancer treatment.

There are other reasons a person would be considered immunosuppressed, and plenty of non-chemotherapy drugs that have immunosuppressive effects. But yes, cancer is one of them.

It would make no sense to include immunosuppressed people in the initial trials for a vaccine, the purpose of which is to determine whether a vaccine can induce an immune response.
Moral Grandstanding. It's also an argument by analogy and the analogy itself isn't good.
Apparently they did donate things, according to the brew team on this very post.
PureOS is trying to use desktop apps instead and fit them to the phone screen ("convergence"). I think it is a viable strategy.
Great. So then farewell CARA (http://cara.nmr.ch/doku.php), we had a good time.
At least a year. There is incentive misalignment. As is normal. Wearing a mask doesn’t bother me. I can get through another year of social distancing and caution.

I can wait for better data.
Gonna need a citation on that all caps “proven.”
Also, Anybody who has received an organ transplant is immunosuppressed. They take immunosuppressive drugs so that the transplanted organ is not rejected.
Release notes: http://hg.python.org/cpython/raw-file/v2.7/Misc/NEWS

TBH I think the main thing about that release, for me, was the introduction of context managers ("with"). I don't remember any particular breakage but I wasn't doing sysadmin at the time, maybe there is something in the bowels of redhat that relied on some broken behaviour...
> just take your responsibility and dont take it

Is that going to be allowed? Do we seriously believe at this point that governments aren't going to make these vaccines mandatory, if not for everyone explicitly then at least in practice by making them mandatory for access to public services and spaces?
I also appreciated the DeepMind blog post about the findings: https://deepmind.com/blog/article/alphafold-a-solution-to-a-...
I find fatFire an amazing sub to read - its like a parallel universe of people in their 30-40's with 8-figures in the bank or investments
There are lots of 18650 "manufacturers" that actually just buy used batteries, re-wrap them, and sell them as new. I imagine that used Tesla battery packs may be used for this purpose pretty frequently. Unfortunately while this activity provides a great value for the players involved, the batteries are often passed off as new high-discharge cells to consumers who use them for vaporizers or flashlights. Using old spent cells for both of these use cases can be dangerous, but it's particularly worrying in vaporizers because the battery may fail catastrophically inches from the consumer's face.
> At the self-described “heart” of the company’s monitoring software is Monitor AI, a “powerful artificial intelligence engine” that collects facial detection data [...] to identify “patterns and anomalies associated with cheating.”

> "... people who have some sort of facial disfigurement have special challenges; they might get flagged because their face has an unexpected geometry.”

So this company is extrapolating "patterns ... associated with cheating" from facial geometry. This is just phrenology laundered through their "powerful artificial intelligence engine" black box. Predicting behavior from the shape of someone's skull is still bullshit pseudoscience, even if the calipers[1] are replaced with a bunch of linear algebra.

[1] http://antiquescientifica.com/phrenology_calipers_George_Com...
The only reason anything has value is if people value it...value itself is a social phenomena, and this includes any type of monetary vehicle, whether a government backs it or not. And maybe I have been living in a fantasy world, but your comment about literally all other commodities on earth not being constrained is literally wrong. The study of economics and wealth is rooted in scarcity and the ability or inability to get more of something.
Sounds on par for this clown car administration.
So you're agreeing with me?
In that case I'll go ahead and email the mods to ask.

Thanks for the response, I hope to target PC and Mac early next year
Sometimes announcements like this are a bit over-the-top. But what really, to me, cements the 'big-deal' of this is the "Median Free-Modelling Accuracy" graph half way down the page.

Scores of 30-45 for 15 years. Now scores of 87-92.

This isn't a minor improvement, it's a leap forward.
When I went to college, our department gave two grades on the transcript: percentage mark and class ranking. The ranking is your ranking among all the sections of that class taught that semester.
That's a very interesting take!

I'm not sure how much to read into it, there are so many variables to consider I doubt this study qualifies as science (like most of social science).

Incidentally, I failed the marshmallow test and I tend to behave and think with a scarcity mindset (I can't tolerate wasting food, it's hard for me to spend money).
My parents are quite well off and went to uni. Their parents started middle class and made some money.
I bet my parents wouldn't have failed the test - and they definitely always stocked the house with food and could provide resources and a stable environment.
My grandparents had a harder life (thanks to the wars, most likely) and share the same mindset I had (even though I never spent much time with them, we lived far away).

I wonder how much of that it's actually genetic, more than environmental. You could still find correlations compatible with the study, if it were.
Passing down the "poor" genes would create genealogical lines of poor families.
Just one part that I object to:

body {
letter-spacing: .02em;
}

I see people doing this from time to time, and it’s almost always a bad thing: why are you second-guessing the expert that made the font? In this case, the font’s already quite a wide font, and the further bump definitely makes the letter spacing unnatural and slightly hinders reading. I could tell as soon as I opened the page that extra letter-spacing was used.

(I also wouldn’t mind the font size being increased from 15px back to 16px.)
This is a huge jump forward. Last year's performance already was a big step up over the previous, and this seems to go much further. So big kudos to the research team.

Nonetheless, I'd like to hear more from specialists outside the context of a marketing blog post before I fully buy into a claim of a solution.

There's also a rabbit hole about what 'solution' actually means. Is the performance sufficient for any protein folding prediction application that might arise in the future?
I think it's pointless to debate a methodology without a purpose. "How many registers does an x86-64 CPU have?" is interesting (to 58 voters so far) but too general to be useful for any particular purpose. Consider a couple alternate questions brought up in this thread:

* How many bytes of register files does the OS have to save on task switches? (With this question, subregisters shouldn't be counted.)

* How many registers does an emulator (such as Rosetta 2) have to implement and test? (Subregisters should be counted.)

Even these one might argue aren't directly useful; when considering context switching, one could dig down further into how much of the context switching time is attributable to saving the registers, validate that with experiments across architectures, etc.
Man, I remember running folding@home years ago on my terrible laptop. Now this was done with what they say is equivalent to only 100-200 GPUs. Crazy to see how far we've come in just a short amount of time.
I think the paper is available here: https://www.imperial.ac.uk/media/imperial-college/institute-...

One really weird thing I noticed is when they talk about the limitations they mention issues around sensitivity but there is nothing in the paper that talks about specificity issues. The combination of non-zero false positive rate, lowish real rate in the population ~1% according to the test and testing people without symptoms surely creates a problem with the results. I guess for looking at differences over time this might not be a problem because the specificity/sensitivity issues should be a constant.
Now onto the much harder problem of doing the reverse: taking an arbitrary structure and determining an amino-acid sequence that will fold into it.
I don't think anyone on HN is going to have more authority to qualify the results than the independent experts quoted in the linked article. Among whom are numbered a Nobel laureate, the president of the group that designs the tests of protein folding systems, and the former CEO of Genentech+current CEO of Calico.
State vs. Behaviour Verification
I'd suggest uBar, which brings the windows bar to MacOS

https://brawersoftware.com/products/ubar
There is probably a team at DeepMind working on cracking simple crypto.
Problem is, it can be difficult to cast the problem properly/“correcty”. How does a one way function get represented?
That's super reductionist. Balancing salty and umami with sweet is so common that you should be surprised that it took so long to realize that adding it directly to the fries makes sense.

BBQ sauce is full of sugar. Ketchup too. People dip their fries in ice cream. Chocolate dipped pretzels work on the same principle. As does candied bacon and apple grilled cheese. Your Thanksgiving Honeybaked Ham is glazed in a sweet sauce. Turkey and cranberry sauce are a match made in heaven. Bacon and maple syrup were practically made for each other.
I used to feel the same way (specifically around the Fed and Treasury and national debt) - until I realized, it's just a number on a screen. They print dollars as easily as you and I print from our local printer. The digits are all are meaningless - we're never going to pay back the amounts, or our national debt. We're just going to print and inflate, and pay back any old sums with numbers we just printed.
Ah, I meant that while they could have said "we're confident only x% of games have cheating, it's not as bad as you'd worry it is", they 'own' it and say "we know it's a problem, we all know a cheater, we try hard to stomp it out".
A Short Profiling Story
Cheating is rampant in in-person learning as well. We shouldn't be treating online learning the same as in-person learning. I took distance learning classes back in the early 00's. Some courses required proctored exams, some had open book exams. For proctored exams, I would do them in the library, then the librarian would send the test back to the school. The open book exams weren't really any easier - you were expected to know the material and therefore the tests were more challenging.

In my professional experience, GPA has little correlation with how well someone can do a job. GPA going up or down by 0.3 points really doesn't mean that much to me.
Check out Dr. John Campbell's video titled "The next COVID year and vaccine function".

http://www.youtube.com/watch?v=smm_ZvJqJk4&t=7m28s
But that would distort the risk for "people over 80", wouldn't it? Like if you are in a nursing home, the risk is probably higher than average for that age group, if you are not, the risk is lower than average.
Just wait until you find out how much money is lost because an underfunded IRS believes it is unable to effectively audit the wealthy and so mostly doesn't bother.
This is a big step forward, but the outstanding question as far as to whether or not this is useful for evaluating novel proteins, is going to be how good is the confidence metric at telling the user to trust or not trust the results. You can see from their examples, that AlphaFold is very good but not perfect. I imagine for some proteins it will still give misleading or erroneous results and if you can’t tell when that happens without verifying the structure experimentally then this will likely not be that useful for new science.
The best fries I ever had were cooked in beef tallow in a small burger joint in London somewhere around here about 10 years ago, https://goo.gl/maps/jzoMt5neajiRpGUY8, the burger was good but the fries were great.
GM's Shrinking Deal with Nikola
Interesting that the list of image upload sites is a who's-who of sites. Always looking for alternatives to Imgur which is laden with ADs and doesn't work with an AD-blocker turned on (it explicitly asks you to turn it off)
Then why hasn't it done any of those yet? Bitcoin came out in 2009, Facebook opened its doors to the public in 2006. One achieved world dominance, the other still can't get out of being darknet money.
It wasn’t “the administration.” The $1,200 stimulus is structured as a refundable tax credit. The CARES Act itself—which was enacted by a Democratic House and Republican Senate—clearly requires everyone filing a joint return to have a valid SSN. Section 2201(g) says:

> (g) IDENTIFICATION NUMBER REQUIREMENT.—
‘‘(1) IN GENERAL.—No credit shall be allowed under subsection (a) to an eligible individual who does not include on the return of tax for the taxable year—
‘‘(A) such individual’s valid identification number,
‘‘(B) in the case of a joint return, the valid identification number of such individual’s spouse, and
‘‘(C) in the case of any qualifying child taken into account under subsection (a)(2), the valid identification number of such qualifying child.

> ‘‘(2) VALID IDENTIFICATION NUMBER.—
‘‘(A) IN GENERAL.—For purposes of paragraph (1), the term ‘valid identification number’ means a social security number (as such term is defined in section 24(h)(7)).
FCC Chairman Ajit Pai to Exit Commission After Biden Takes Office
How was your experience switching from Android to iPhone? The last time I used an iPhone was the iPhone 4, but I've been seriously considering switching back for privacy reasons.
Oneplus devices are perfect for trying out new ROMs. e.g. my OpO runs LineageOS, UBPorts, Sailfish, Purism etc without any issues. However there are other devices as well like the Fairphone etc which are equally good.
Well, what this API's implementer could have done, is to catch the IOException and throw RuntimeException. That makes sense, because there is no reason during normal program operation for this API to throw IOException, so if it does it must be an internal bug in the library.

This pattern is equivalent to Rust's `unwrap` and `expect`, than can be called to transform a recoverable error into a panic.
We don't know a priori who will have very adverse reactions. Comorbities and old age increase your chances, but those are categorically not the only variables at play.
And autoimmune conditions, robbing a list from wikipedia: celiac disease, diabetes mellitus type 1, Graves' disease, inflammatory bowel disease, multiple sclerosis, psoriasis, rheumatoid arthritis, and systemic lupus erythematosus.

I don't know how many people with conditions take immunosuppression medication.
I take it for arthritis and alopecia and have come across many people on similar meds for diabetes or other things.
But that could be a form of confirmation bias
why do people discourage technical analysis and liken it to astrology?
We can already determine how a few proteins (170k — which sounds like a lot, but which is only 0.09% of all currently-catalogued protein sequences) fold by experimental work.

What an accurate model of protein folding allows us to do, is to take our big database of DNA, predict protein foldings for all of it, and then stand up a search index for this database, keying each amino-acid "row" by the "words" of its predicted protein's structural features.

We could then, with a simple search query that executes in O(log n) time, find DNA targets that produce molecules with interesting structures that might be worthy of study.

This would, for example, be a game-changer in how biopharmaceutical macromolecule-therapy R&D is conducted. Right now we have to notice that some bacterium or another produces some interesting protein, and then engineer a bioreactor to get more of that protein. With this tech, we can work backward from an entirely hyothetical, under-specified "interesting protein", to figure out what catalogued-but-unstudied DNA sequences produce never-before-catalogued proteins that fit that particular functional "shape", and therefore might do the interesting thing. Then we can either directly synthesize that same DNA, or find the organism we originally sampled it from and study it more.
I can remember taking many exams in the athletic field house at my university back in the 1990s. It was pretty standard when you were in a large class.

The desks were so far apart that the current "social distancing" standards would be met. I remember that many courses had multiple variations of the same exam given to students to further reduce cheating.

I'm taking an online masters right now and have taken a few (pre-pandemic) proctored exams. The nearby university offers to proctor any exam for $10. They have a bunch of rooms with desks, and it's no big deal at all.

This proctoring technology thing has gone too far and too fast. It was a knee-jerk reaction, and with a lot of complaints I bet that a lot of it gets dropped.
OSS for operating systems is unlikely to be fine: out of the four classes server, desktop, laptop, phone/tables, one is already fully locked down and with the M1, the laptop class also becomes less open and hackable.

Most people - unlike you - don't care that much about desktops, they either have laptops or tablets.
Immune suppressed/deficient patients are not good candidates for vaccines in the first place, since they would be unlikely to mount an effective immune response.
I never worked directly with protein folding or structure, but worked a bit in proteomics on teams measuring gene expression (which you could roughly think of as how much of each protein is found in this cell). IIRC there are 50,000 - potentially millions of "kinds" of proteins found in a human, and the "shape" of most of them is unknown, and that determines a lot about how they work.

So imagine you gave an iPhone to someone in the 1800's, they wouldn't understand how most of it works, but this may be analogous to them finally figuring out some key aspects of the transistor. So it's another tool in the toolbelt and like all good tools will be used in all sorts of unpredictable ways.

Someone else I'm sure could do a lot better at explaining how important shape is to understanding the function and behavior of proteins.
More GPRs visible in the ISA also means more bits needed to encode instructions. If instruction length and encoding were not an issue, I bet we would have seen memory-to-memory ISAs where no GPRs exist, only instructions referencing memory locations. The dynamic register file would then be just a level below L1 cache, or even completely removed.
Anything with a bandwidth has bitrate:

https://en.wikipedia.org/wiki/Nyquist%E2%80%93Shannon_sampli...
Far from an expert on complexity theory, but NP-hard problems can be approximated in polynomial time. With Deep Learning you are doing approximation. So this is nothing ground breaking in that respect.
I actually remember that I read that story and wondered in my head about the extension length.

But I had two possible ideas what could make the story work. One was that maybe they just hadn't used MS-DOS. There were plenty of computer systems out there and I had no knowledge what they used for programming the original MI or even which one was the original (it was available on different plattforms).

The second was that maybe the extension was something like .brs as an abbrevation for brush, but they pronounced it brush and eventually took the pronounciation as the name, not the literal filename.

Now I know both are wrong.
Little tip, stop drinking coffee after 3pm. Try to drink at least 2-3L of water until 5pm, not later or your sleep will be disturbed by..well pissing, at 8-9 do a little (easy) jogging but not more then 10 minutes, drink a little bit of water after jogging and go to bed 1-2 hours later, you will sleep like a princess.
you can't completely predict who it's going to be mild for. 14-year olds with no known underlying issues have died, 25-year olds have lost their sense of smell and taste permanently or suffer from long covid months later.
In my job I am developing an app in C#. When I joined the team, there was already a Result library which is just a wrapper for return types with predefined set of result codes and a field for error message. It was first used for our bridge with JavaScript code, now it is used (and abused) everywhere in the app. I though it was a big PITA when I joined the team but I see the value now and I think the .NET ecosystem is lacking some standart way of doing this. Yes, there are exceptions, but we have a some states which are not "failured" per se and the Result library fits this well. The system is not perfect because the set of predefined result codes cannot be used everywhere and I am constantly thinking about how it could be improved. Does anyone have a clean way to do error handling in C#?
Your package manager should be boring, extremely backward and forward compatible, and never broken. Experience has shown this not to be true for python. Several times over the years i’ve found myself, pinning, upgrading, downgrading, or otherwise juggling versions of setuptools and pip in order to work around some bug. Historically I have had far more problems with the machinery to install python packages I have had with all of the other python packages being installed combined, and that is absurd.
Yeah but the thermal expansion/contraction between plastic and composite (PC+GF) would not be welcome. Flip note: glass fiber reinforced polyamide(nylon) and polycarbonate have similar strength to aluminum.

Another issue would be use of adhesive that generally dislike heat even more than the electronics do.
I don't think the problem is that academic rigor isn't good. I also should have stated I was talking more about US universities in this particular case.

The problem I see is that what you talk about as academic rigor isn't what is taught and evaluated in many of the programs and classes that I've seen or been a part of. A lot of these exams and assessments don't particularly evaluate you on your ability to research and understand knowledge. If I know for example that my physics professor uses a bank of questions then it is much more incentivized for me to memorize that bank of questions vs. understanding the content and working the problems myself. Whereas in say a Discrete Math or Algorithm based class, the final exam/grade is based on a proof you have to write yourself, that encourages (or rather at times forces) you to learn and research like you said.

I also think the issue, and this may just be me looking at from my own experience, a lot of people don't want to be scholars, as you put it. They went to a University based on the unfortunate expectation for some jobs that say you need that diploma as your entry ticket.