skysight-inc/HackerNews huggingface dataset:
"attempts to reproduce similar findings in humans have failed"

CPH treatment may be useful in dementias of medium level in quite old groups of patients, since 48% of the verum group displayed improvements in the memory functions against 28% of the placebo group.

https://pubmed.ncbi.nlm.nih.gov/2506844/

"The drug thus might simply be a treatment for the type of genetic disorder that the mouse model"

Got any experimental or observational evidence for this hypothesis?
In what kind of projects could this phased arrays be used for?
Ignobel prize winner in Physics: the ponytail (2012)
Right. Even if you assume the worst-case-scenario there isn't some standard risk metric nor threshold to meet.

I feel like differential privacy is the strongest definition we have, but it is also lacking from a practical standpoint. What does it mean to have N nats/bits of information gain from seeing the result of a query? How does this translate to my risk of a PII leak?
Uplift Ltd. | Boulder, CO | Frontend Engineer | Remote | Contract/Freelance

Uplift isn’t your typical consulting agency. We’re a fast paced incubator of products. We’re a group of incredibly smart, passionate, well rounded individuals and we’re looking for other engineers to join our stellar team.

Design your own work schedule. Work on a variety of projects. Utilize our shared resources.

What we’re looking for:

React Native / UI Engineer

* React Native (at least 1yr of experience preferred)

* React experience (the more the merrier)

* TypeScript

* GraphQL (React+Apollo especially)

* Frontend architecture

Bonus:

* Freelance experience: delivered projects, managed budget/estimate, worked with non-technical clients (most important)

* Microservices, progressive web
* Heroku or AWS

* Excellent CSS skills

* Native iOS/Android

* Can think critically, build from rough specs (no designs or detailed specs)

One of our core values is continuous learning: within the industry & from each other. We welcome people of different backgrounds, experiences, abilities and perspectives. If you're self-sufficient, passionate & a good communicator, apply now!

Begin part-time and go from there. Must be in U.S. Timezone.

Visit: https://www.uplift.ltd/careers/

Email hn@uplift.ltd with your location, preferred working hours, and details about your experience with the above technologies.
With user generated content apps it isn't the software that is the main maintenance job, it's keeping out abusive content.
Azure DevOps actually includes quite a bit of Mac-based compute for free (no M1 yet). I use it to prepackage TensorFlow.
Dexterity Capital | Fulltime | SF, Seattle | Back-end engineers | https://www.dexterity.capital

Join Dexterity Capital's growing team. You'll create our next generation systems that power our high-frequency trading firm. You should be excited at the prospect of shaping our data pipeline, and building a low latency trading platform. Our small team is already trading billions of dollars every month, and we have ambitious goals for the future.

About you:
- Exceptional at writing scalable, and production-ready code
- Thrive in a fast-paced environment
- Proficiency with one or more object oriented languages (e.g., Java, C++, Python)
- Looking to tackle on hard problems
- Live in San Francisco or in Seattle

Great to have:
- 3+ years of backend engineering work experience.
- Deep understanding of Apache Spark
- Experience working with huge data sets
- Experience with with Websockets
- Experience with AWS

About Dexterity Capital:
- We are a leading trading firm focusing the cryptocurrency space
- We value growth, our own time, and getting things done
We currently have under 10 employees and are looking to grow to 20 quickly
- We offer highly competitive compensation and comprehensive benefits

Feel free to reach out to me directly alex@dexterity.capital
Now that you mention it, the story does have that "too inherently viral to be true" smell.
OpenGL 2D Facade (17): Mixed text styles – Design Patterns and Video Games
Looking Glass announces as $200 holographic display
I quite enjoyed it, and think it's worthwhile.

Suggestions:

-The targets for mouse clicks are definitely too small (you've heard that already). Could also do something like clicking whilst zoomed in to zoom back out, or just standardising the buttons to +/-.

-Add a way to get all the way back to the preamble, and a writeable notepad of some description.

-Tighten up the initial login validation - I found plausible passwords that neither passed nor failed, if that makes sense. (DM me for details, or I can write up here if you like.)
I used to agree but a few of my 20-29 year old friends have had much worse experiences than expected. One had some neurological side effects, which is rare but happens, that affected his eye movement and made it impossible for him to read or work comfortably.

It wasn't healing and it turned out he had an undetected issue processing folic acid I believe, which has an effect on how your body heals from neurological damage. He's recovering now after 3 months but has to take folic acid and other supplements 5 times a day.

Other friends have had persistent diminished lung capacity for months on end; these are folks who had no co-morbidities and in their 20s.
Well, it's all in the heads...

There's rich interaction between how the world is, how one perceives it and how you act on the beliefs you acquire.

And I agree, the technical data concerning (physical) violence, disease and wealth look good.

But that's not all there is to life, is it?
It is. I'm in southern California in a fairly high density area, and my only options until recently were 10mb/1mb cable internet with a 1TB data cap for $60/month and 1.5mb DSL for $15/month (no data caps though). TMobile recently started offering internet over 5G with no data caps, so I'm going to try that to see if it's better.
Unmet job expectations linked to a rise in suicide, deaths of despair
> I try and force these incurable skypers to send an email instead: it forces them to really think their stuff through, organize it in a more structured way, and takes me two minutes to answer instead of having a 15 min call that is all over the place.

This is a great way to handle people who jump straight to "let's just do a call, it'll be easier [for me]"

For people who are like this, I will often just say I'm not available for a call for a few hours, and ask them to send me a written message in Slack instead. Most of the time, I am able to just help them async on Slack instead of spending 30min-1hr (x2 since we're both in it) in a call.
Eh, nobody understands everything simply because you need to sleep around 8 hours a day, and give at least a few other hours for other functions. There are limitless rabbit holes you can fall into and never gain mastery in the subject.

Like describe the supply chain for iron, now do it for gasoline, now do it for silicon, copper, gold, crops, etc. No matter what your think, there isn't some person that understands all of this. They farm off the technicalities to people that are dedicated to it.
this person out here with no unskippable ads.
For a company with such a massive advertising network, they kinda suck at marketing their own products and services. E.g. https://twitter.com/JesseLehrich/status/1253824612179292160
... in the freemium edition, that is. The premium edition, however ... (joking)
I'm not in the U.S. I'm in Algiers, Algeria. North Africa.

I will probably buy many StarLink terminals to put in several places, offer to family and friends, and, frankly, out of spite.

https://www.speedtest.net/global-index

Two positions from the bottom. It's faster to start from the bottom. Although if you're on mobile, you won't see the ranking for fixed broadband. It's only better than Yemen and Turkmenistan. It has worse fixed broadband and mobile broadband than fucking war zones. How is that even possible, even if you make efforts to make it possible?
It would be nice to have a direct comparison with ugrep. In the case of rg the benchmarks are already enough to switch. Why should I use rga instead of ugrep?
Yes, I know it and browse it frequently - a great resource, if you've an interest in or need for this type of 3D asset. (I used to run a 3D animation software company.)
What you are asking for is not equality - equal chances for men and women to become suicidal - but equity, equal numbers of suicidal men and women.
Good thing we have GPT-3 now. We can just ask it complex questions about the world and it will tell us the answers via auto-complete prediction of the next word in its sentence!
> small percentage

If I carried the decimal correctly, 5 thousand out of 58 million is less than 1% of 1%.
Principles of Compiler Design is old but still a great book, one of the best CS books I've read and it got me going with compilers. I'm reading an old copy from the 70's.
Google has 2 billion users or thereabouts. 5% of that is 100 million users. Why not maintain a product for those 5% if it's easy?
I'm in slight disbelief that I can't find anyone pointing out that the y'th root of x can also be written x^(1/y) - it must be in there somewhere...
My understanding is that part of the reason AMD went with a chiplet design was to work around this issue.
> ...lawyers spoke to the EU and were told this needs to happen right away

Sorry but this is not how EU works and it doesn't make any sense at all.

You can't "speak with the EU", in the same way you can't "speak with the United States of America".

You can speak with a data regulator in a specific country if you wish so. But each one of them is also part of the European Data Protection Board, which ensures the consistent application of data protection rules throughout the EU.

I can understand lawyers speaking with one of the regulators, and been told about the ePR "ePrivacy Regulation" proposal that looks to repeal the ePD "ePrivacy Directive".

But we live in a sane world (at least here in the EU) where impactful regulations and directives don't change overnight without any notice and implementation period. The ePR "ePrivacy Regulation" draft suggests a 24-month transition period, similar what happened with GDPR which was agreed in 2016 and went live in 2018. So the earliest ePR will take effect as of today is 2023.

Having some "lawyers speak with the EU" about some unannounced "internal material" that "need to happen right away" doesn't make sense.

So no, I don't see how your or Facebook changes were influenced by ePD "ePrivacy Directive" from 2002/2009.
I think it's plausible that the Chinese cloners never bought the original product but instead hacked his server that had all the photos and schematics to produce the product on their own. No, I don't have any evidence for that being the case, but I think it possible with this being the direct method counterfeit groups use to knock off most things from Western countries.
> All of this comes in a single binary that is easy to install, easy to use, and easy to deploy.

And it looks like they chose a sensible license for that binary [1], so they're not giving too much away.

I wonder though if they could have made this work as a bootstrapped business, so they would answer only to customers, not to investors chasing growth at all costs.

[1]: https://materialize.com/download/
That first metric is highly subjective. There is a growing movement of anti-natalists that believe that having children is immoral, because being born a human is worse than never having existed, and people can't consent to their existence.

I don't think we'll be able to move beyond subjectivity for the morality of this, but I do think we can be more precise.
Hierarchal organizing of data is not a productive way of organization. Simply due to how much information people accumulate and often times structures breakdown.

It's more intuitive to simple search for something in the something you are looking for and clicking it.

I haven't used a folder organization structure in many many years. Other than the defaults for my cloud folders and a separation between Personal + Work.
The lab grown meat is just a single cell type at this point, correct? A perfectly lean mono-steak would be awful. Until the lab can figure out other basic things like how to grow fat and then get it marbled through the steak, we're a ways off from getting lab steaks that anyone wants to eat.
Intergalactic Aerospace Expo 2950
Cheese and butter have very little lactose, and yoghurt has only a quarter of lactose content of milk. In many human populations without lactose tolerance, preparing these was actually a way to consume milk they couldn’t drink directly.
CDC has a page [1] with the notable historical vaccine adverse events. I think it's an informative page to read, but just in case you don't have time, here's my summary:

- most adverse events were due to manufacturing issues (e.g. contamination with some live virus). In this respect, I don't think the Covid vaccines are likely to be any more or less risky than other vaccines, such as the annual flu vaccine

- two vaccines had an association with the Guillain-Barré Syndrome (GBS). Even nowadays, if you take the annual flu vaccine they advise caution if you've had GBS before.

- one Rotavirus vaccine was quickly discontinued after they saw it can cause a serious condition called intussusception

- finally, a case that you'll hear lots of people talking about, a possible link between a flu vaccine adjuvant (AS03) and narcolepsy. The CDC page directs you to the actual study [2]. My summary is that this link was observed only in Sweden and Taiwan, but in no other countries. The Pfizer and Moderna vaccines do not have adjuvants (but Novavax and others will have).

[1] https://www.cdc.gov/vaccinesafety/concerns/concerns-history....

[2] https://pubmed.ncbi.nlm.nih.gov/30122647/
Perhaps Spotify offers a good example. Free tier is funded via ads. Premium tier, no ads + other benefits.

I expect you'd find that there is a significant segment of users who would be willing to pay for the service in order to not be targeted with their specific characteristics and use patterns. Brands can build trust, perhaps make that an objective to support subscription sales.
I'd like someone, maybe me, to synthesize Adam's confusopoly, cybernetics, Graeber's bullshit jobs, and Shirky's prior distillations wrt attention and power laws.

--

I'm intrinsically a deeply cynical, skeptical person.

And I've never been more optimistic.

We're finally able to start answering some of our millennia old philosophical questions.

It's an amazing time to be alive. I can't wait to see what happens next.
> The right thing to do by Google would be to make the product available as a stand-alone application, so users can still use it even if it doesn't run on Google's infrastructure.

Did any of your companies ever do that? How did it go?
Aids, from the Perspective of “Patient Zero”
It does say "here you will be able to find Anne's location", I'm just saying author got lazy and didn't actually post something about the location?
> will not buy laptops priced $ 1,000+

The iPhone and iPad are using up a lot more of TSMC's capacity than the Mac. Also most sub $1k laptops and lower end phones not getting chips with the latest TSMC silicon in them. They are getting older 14nm Qualcomm, AMD, or Intel CPUs.

EDIT: I previously implied all sub $1k laptops had 14nm CPUs which isn't true.
Example of Twitter post for hitting a milestone
Probably already known but people at Google get promoted because of launching new products, nobody gets promoted for maintaining an existing product. Is a mafia, Product Managers, Engineers, TPMs that want to go to next level all play the same game and the organization allows it. Ok product is released, then the team moves to the next sexy thing, and the product end up being replaced by some new team members or contractors take over and at the end, product just dies. Even worst in Cloud just playing catch-up with AWS and the same history repeats just that know you have Enterprise customers which wouldn't be happy...and what this causes is that externally and internally you have bunch of products doing the same things (messenger apps, notebooks)
I am personally quite terrified of the possible unknown long term side effects of COVID-19 and largely confident that the vaccines are going to be safe.

If you offered me a vaccine tomorrow vs a 100% certain mild case of COVID-19 that would guarantee me immunity for a year so I could get the vaccine in 12 months when there was /even more/ confidence about the safety of the vaccine I would take the vaccine.
Thanks for the explanation. I'm going to look more into this as I'm working on a new service on top of Vertica. There is a lot I don't like about Vertica and don't see alternatives such as Snowflake to be much of an improvement.
> grow them in perfect conditions

Sci-Fi reader part of myself wonder if there could be some information theory aspect to a perfect-mess of meat, that the food must grow within a context relevant to the consumer, i.e. a perfect piece of meat or a carrot from 100 years in the future or past is not perfect to us in present.
Absolutely. This is not a feature which any employee ever wished to have. This is aimed 100% at managers and people who decide on which products the company should buy and no better way to persuade them by giving them a surveillance tool on their employees. It will come back in pieces.
The point is that if the attacker can connect your user record in the source data with user # 188da24a7789d in the "anonymized" data, they can use that de-identify all information derived or built on the "anonymized" data.

Oh, there is Netflix account for user # 188da24a7789d and the IRS released tax summaries for user # 188da24a7789d? That's interesting, since I know that user # 188da24a7789d is really MaxBarraclough.
https://github.com/vnmakarov/mir
How to Receive Feedback Well
The Tours of Dr Syntax (1809–1821)
Curiously, this vessel appears to have been registered in the Marshal Islands, which is an independent nation with a rather unusual relationship [0] to the US that I hadn't heard of before. Presumably the law that requires US registration has a special provision allowing this? I wonder if the crew requirements are more relaxed with a Marshal Islands registration?

[0]: https://en.wikipedia.org/wiki/Compact_of_Free_Association
They have done nothing. They just stop showing names . Data is not being collected in a anonymous way
Did you implement this policy at any of your companies? How did it go and how much time did it take to release the software?
How do you handle this now as a singleton developer? Do you solicit reviews from private collaborators for parts of your recent work that aren't open-source?
TSMC is absolutely killing it, but Samsung is catching up too.

https://techxplore.com/news/2020-11-samsung-chip-wars-tsmc.h...

Still, I think there's a pretty reasonable argument to be made about our dependence on foreign entities for such critical infrastructure. Intel seems to be falling behind pretty quickly.
Looks like it was already withdrawn and superseded by this: https://assets.publishing.service.gov.uk/government/uploads/...
Is your front-end still a React app served entirely out of static storage? If I were doing a serverless project with a web front-end, I'd look into some kind of server-side rendering, so I don't have to degrade the user experience to get the type of infrastructure I want.
Japan's deaths per 1M is 17, whereas the US is at 836. Doesn't seem that bad to me.
I sympathise with the guy. I've seen too many things you cannot unsee from some data streams.
Well, a country is a shared endeavour isn't it? We collaborate together by following our national laws, paying our taxes, follow our customs and traditions and engage in cultural renewal and repair when required. In this way, everyone in the country is responsible for fostering a peaceful and prosperous environment that can prove to be fertile infrastructure for advancements and breakthroughs. Why not take some small measure of pride in this? It's a generational effort.
Smartphone mobility and social graph data that’s already being collected and analyzed. Rather than just using existing tech to target ads and build surveillance capitalism profiles, it could be used in the public interest. On an opt in basis naturally; but as frictionlessly as possible via cookie tracker popups and updates to FAANG terms of service perhaps.
Or is it even real or nocebo/anxiety from constant fearmongering and propaganda? Why are most long Covid sufferers young, female, white and on Twitter?
This is an interesting premise, but I don't think it really holds up. The world is absolutely too complex for any of us to understand everything, but this is not a problem. You can abstract everything away to 'black boxes', and there are always a few people that understand what's going on in those 'boxes'.
The Future of Space Warfare
Printed Links Detector
Surely it cannot be me who is wrong, it is all of those who are insulted by my work who are in error.
The comma is important. Or replace 'which' with 'and it'.
Vegetarianism is growing in other parts of the world, like France, and for much of the same reason as in the American West Coast.

While you're right that there might be more attachment to 'traditional' and overall high quality meat, there's still a big movement for cruelty free meat as you can see by the impact of associations like L214 for example, or the fact that there was an increase of 25% for the vegetarian market in 2018
My father drove me there on a whim when I was about 6 years old and asking about about it. We lived about an hour and a half away.
I got frustrated trying out different passwords, so I looked at the source code.

The username is "anne.kingston". I found the password hash, but not sure how to go back to get the password itself.

Password hash: (hashy == "3880" && saltedhashy == "2425")

The hash is computed in a loop as: `prehash += (s[i].charCodeAt() * (i+1));`

I'm not sure how to go reverse this. Maybe someone can help?

Here's a tuple of passwords tried and their hash and salthash:

(Password, Hash, Salthash)

(daniel, 8221, 2197)

(hello, 7004, 3970)

(password, 3970, 1268)

(123, 302, 4415)

(something, 4814, 2749)
This. Spent almost 3 years at Google and my view is that it is an intended side benefit of how they do development.

If something that relies on say, one of their log services, and that log service is getting end-of-lifed then all the dependent services that aren't really critical will also get shutdown. It's a forcing mechanism to keep the amount of cruft down. If that service that relies on the old service is that important they'll put the resources on the project long enough to port it to the new service.
I'm saying that I think there are programs that are good and beneficial, and others call them "evil, wealth redistribution." Well, if that's the majority view in a state, and that state also takes in more Federal dollars than its residents puts in, then maybe for Defense spending they shouldn't be able to take money from another state. They can self-fund it. And if they can't maybe it makes more sense that the jobs that come from Defense spending should go to a state whose residents are willing and able to pay for it.
> I hope the founders made out like bandits when they sold out, and I hope it launched them onto spectacular career trajectories.

Well uh... The company went under, so I doubt they made out like bandits. The IP was sold off, but I suspect that much of that money was used to pay off outstanding liabilities. My impression was that the founders tried to do right by their employees as well. I find it unlikely that they came out of the process with a ton of money- more than likely they lost money.