skysight-inc/HackerNews huggingface dataset:
You won't forget directions when it matters.

If you can't remember how to get to a certain place without a navigation app, it's a sign that that place is not close enough to you for it to actaully matter.

I really do not understand people who cannot do without navigation to get home when they visited a friend for the first time.
This is my biggest complaint about Discord, and the reason I rarely check the few servers I'm on. There are three channels out of 80 I'm interested in. Just let me leave them!
Message-Based Parallelism with Actors
I bike, run and climb (in that order). Around 50-100 km a week cycling, maybe 10-15 running and once climbing (not anymore since the gyms are closed). Mostly its training for bigger rides I do, I enjoy going to the mountains or around lakes/between cities on longer 100-200km rides. This all of course depends on weather and general motivation but I generally stick to it pretty well.
About 7 years ago I did the same. 2 engineers, 2,500~ physical machines (6 were elastic search nodes).

We were highly effective, sure, but like, it’s not as hard as people seem to claim as long as you’re paying for the datacenter space already.
I wonder how long it takes from getting started with this (as a software engineer), to being able to create graphics like the svg examples presented here.

Mind-blowing. Especially those printed using a plotter.
For the Love of Troff (2020) [pdf]
In bacteria, they produce a lot more mutations in stressful environments because it is evolutionarily advantageous. In other words, if your situation is killing you playing Russian roulette with your genes is a better bet than accepting certain doom. Maybe you produce a deadly mutation that kills you and maybe you produce a mutation that helps you survive certain doom.

My recollection is that snails can reproduce either sexually or asexually and they preferentially reproduce sexually in stressful environments and asexually in environments that make staying the same more advantageous.

Sickle Cell is protective against malaria. Sickle Cell trait is protective without causing Sickle Cell Anemia, which is a horrible condition. So one copy of the mutation and you are more likely to survive in an area where malaria is prevalent and two copies and you are jacked up, but maybe less jacked up than with malaria.

Some studies suggest that Cystic Fibrosis is a predominantly Caucasian disorder because having one copy of the gene is protective against certain disease that were sweeping through Europe at one time. Two copies tends to kill people gruesomely at young ages.

So I think generally speaking the answer is that species seem to seek mutations when what they are doing currently isn't working and seek stability when what they are doing currently is working.

Also I have read that it is believed that half or more of all human pregnancies probably end in the first two weeks and result in a heavier-than-normal period without the woman even realizing she was ever pregnant in most cases because those fetuses are simply not viable. Laying bets on "Will this novel mutation or novel combination work?" tends to get a result of "Nope. It so doesn't work, it's not worth investing precious resources in to bring the baby to term and let it be born."

We mutate more when it is "mutate or die" and less when mutating is the thing more likely to kill you.
I just looked it up briefly and I like the idea of topics, but I think there could be too many and it could become messy quickly. Certainly on the right track though.
Australia has been trying to do this for a decade at least. In fact they technically already have — they can demand that I, as an Australian citizen, build in a Backdoor for the federal police and intelligence services into any system I work on, and gag me from speaking about it.
Eat Just to sell lab-grown meat after gaining “world first” regulatory approval
Thanks for the tips and sorry for the hassle! I admit I didn’t test on Windows :(
Trump vows defense bill veto unless internet liability shield scrapped
Currently that’s most politicians, and effectively all politicians that are in the majority parties worldwide.
AWS engineer puts Windows 10 on Arm on Apple Mac M1 – thrashes Surface Pro X
How much money have these kind of speculators shovelled to politicians in order to promote lockdowns and mask mandates?
Or you could be like Jonathan Blow who claims he never has any memory bug issues and so it's not a problem worth solving in his JAI language.
There can be multiple valid folds, the most famous ones are prions which are a different fold of an protein than the native one.

The explanation why proteins typically only adopt one fold is not in the process of folding itself. But misfolding is really problematic for the cell, and there are various mechanisms to manage it. A misfolded protein is at best useless, and as you can see with prions can also be actively harmful. The cell has chaperones that help proteins fold, and it has quality control mechanisms that try to remove misfolded proteins before they are released into the cell.

But one major factor is evolution, proteins that fold reliably are selected over proteins that can fold into unproductive or harmful conformations. So the proteins we tend to look at already have been selected for their folding properties to some extent.
There's another great scene in that movie which also captures this really well, when Ben Rickert (Brad Pitt) explains to Jamie Shipley and Danny Moses what it means for normal people if the group's big bet against the economy pays out.

https://www.youtube.com/watch?v=0k5aVLi_yhM
Does anyone have any non-press infested material about this vaccine? As far as I’m aware this is the first roll out of an mRNA based vaccine.

While I’m no anti vaccination idiot I’d like to understand the risks to some degree.
You need three things:

0. A function A(s) to generate actions (moves) A given a state s:

1. The state evaluation function v(s) to distinguish good from bad states. I would start by using only piece value, then add mobility, piece-field values, ... You can find a few simple elements of such a function
here: http://manual.freeshell.org/gnuchess4/HEURISTICS

With this you can generate s'=as (Successor state is action a applied to state s) and choose the action a=argmax(v(s))

2. A simple minimax implementation that searches the possible moves https://en.wikipedia.org/wiki/Minimax

From there you start optimizing your both by adding additional features to the evaluation function and improving your search using pruning and caching
True, though also my amateur understanding is that ageing-related illness is better modelled that’s e.g. cancer. This is because ageing is a natural thing in all species, whereas for specific diseases, indeed you genetically engineered “mice with cancer”, which behaves then very differently.

Could be wrong ofc!
How the Brazilian Startup Ecosystem Is Driving Innovation in the Space Industry
Blinded by Scientism
Location: Melbourne Australia

Remote: Yes

Willing to relocate: Within Australia

Roles interested in: Technical Product Management, or fullstack rails development with product management

Technologies: Ruby on Rails (RoR), Full stack (html, css, js), SQL + much more.

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Email: AusTechie@protonmail.com
Swift is far more like C# than Rust in terms of memory management. Sure it uses ARC but arguably that makes it not suitable for kernel level stuff.
Maybe you should read it. "There is a tendency for Western soldiers to dismiss … because the videos show limited tactical proficiency … This is misguided for several reasons." In other words, you're misguided.
Yes, so to quote from it [0]:

> This decoupling and targeting a specific set of faults allows our system to provide high availability and strong consistency in face of various classes of failures we see in practice.

What that says is: for the failures we have seen so far, we guarantee consistency and availability. But how about the other kind of failures? The answer is clear: strong consistency only is guaranteed for _certain expected_ errors, not in the general case. Hence generally speaking, strong consistency is _not_ guaranteed. As simple as that. Saying it is guaranteed "in practice" is, pardon, stupid wording.
Never thought I'd see Saki mentioned on HN!
I’m going to be building a compiler over Christmas break, and I was thinking of targeting the LLVM toolset. This will be my second compiler; first one emitted x86 directly. Should I consider switching to QBE? I’m more focused on compiler passes that I want to write; register allocation, etc. is not my thing. I’m going to be working with CPS-conversion ans stuff like that. Does anyone have any good tutorials for using either system?
I just complete my 9th class (GA) and have really enjoyed most of it. AI4R was great, but so was Adv Operating Systems and High Perf Computer Arch.
When RNA is used to create amino acids, is only a specific segment read (if so, by what mechanism?), or does a cell create all the amino acids defined by RNA in one go?
Although it is certainly challenging, you shouldn't spend only an hour reviewing a 3,000 LoC review, unless most of it is trivial refactoring, especially if that code is security-critical and handles untrusted input. That's only 1.2s per line of code. No chance you have good quality control with that amount of attention.

If it's taken someone a whole fortnight to write it, you should expect to spend at least half a day reviewing it, IMO.
The data production-consumption gap
It does. I haven’t noticed anything major.
Okay that makes sense, when we have very low throughput it looks like consistency wasn't an issue but at that rate (especially if it occurs in bursts) I can see how the prior S3 implementation could fail to scale fast enough
The wiki article is a good start: https://en.wikipedia.org/wiki/BNT162b2
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Cash is a great gift for everyone who isn't so rich that gifts are pointless. The war on cash is US corporate consumerism pushing people to waste money.
> in 2018, the team made a $2 billion bet that a series of shopping malls, including Crystal Mall, would eventually fail. If retail tenants vacated and the malls’ landlords defaulted on their mortgages, MP stood to make a killing.

Why should it be legal to make billions of dollars in profit off of the failure of something? How does that make economic sense? These guys walk off with a huge bag of cash, a bunch of investors that were trying to invest positively get screwed, the mall dies, and all that money and economic opportunity vanishes. The economy objectively gets poorer in that area, and the ramifications are widespread as areas start to become 'food deserts' and so forth.

Are we _really_ to believe that the era of the physical marketplace, the Third Location where you can take your family and kill a rainy day, is really dead? Does nobody want this at all, anymore?

Is it possible that we'd already let the malls decay into places people didn't want to be, through lax enforcement of any kind of social discipline that would make it a welcoming space, and this is just the death rattle of the mall from the same problem that will ultimately kill the city itself?

Or is it possible that this is robber-baron capitalism, exploiting anything it can find for profit, lobbying and changing laws to make it easier to vampirically suck the remaining wealth out of troubled areas?
gov.uk: https://www.gov.uk/government/news/uk-authorises-pfizer-bion...
I wonder if a modern discussion platform with Facebook as the login provider (and some deeper integration of content, perhaps?) would help bridge this gap?
Oh absolutely. Nothing nicer than just buying a gift for your partner when you see something suitable, and not bothering with fixed dates at all.
I've had fewer and fewer emails end up in Promotions. Apparently the initial settings were far too effective, so they had to be turned down in order for promotional emails to actually see eyeballs.
It really depends on the equity cost of owning a home. Plenty of people want to live in a location where a home would soak up all or a large percentage of $1M.
I'd be sad about the huge waste. That's why a gift should only be a surprise on the when, not the what.
What’s a blackout shop? I googled it but didn’t find much (this has become more common. Google’s search seems to get less useful for finding new info daily)
Add "in mice" to the title.
Sure, but that’s a scenario where the usage of bitcoin is high and the total amount of money on tax fees is small compared to the market cap of bitcoin.

This means hash rate will be low compared to the market cap, and the necessary capital for a double spend attack may be worth it.

Maybe it’s all less of an issue because bitcoin will develop a network of trust that can replace the block chain.

But then, why not go with something like Stellar right away.
How did they approve it that fast? Is the approval process so different and so much more efficient than the one in the EU or USA? Was it extremely rushed to make sure to get doses before they have to compete with other countries for limited supply? I'm pretty curious now. Let's hope for the best, i.e. a good vaccine, a good process and no trust problems, the latter because at least it feels rushed.
Its not always an option, because of Dynamic IPs, power outages etc. Solving them reliably comes at a cosr and also not so easy.
Original discussion: https://news.ycombinator.com/item?id=23755693
I needed this. Thank you. It’s been all rah rah on my side of things but I totally agree. I want to make an impact on the world and with this accelerator interview, I have somehow landed a dream come true, but I think my biggest risk is not staying humble and realize that I don’t need to be someone else or waste time worrying about competition. I need to be mean. I need focus on finishing this app with customers at the for-front of my mind. I appreciate you :D
For a recent publication, I had to create a neural network architecture diagram and tried it two ways - one by hacking someone's python code to create an isometric 3d diagram (https://i.ibb.co/HdBvTFk/fig2.png), the second using draw.io to create a 2d diagram (https://i.ibb.co/kmrfpVK/fig2a.png).

The 3D figure looks more appealing to my eye, but I went with the 2D one instead. The issue with architecture SVG generation code that I've seen is that it's inflexible once you want to do anything outside common layer computations or arrangements. I found someone's code that had a U-Net example and then manually had to go in and modify a whole bunch of stuff to get it to do just what I wanted. On top of that, I opted to do a bunch of postprocessing in an image editor anyway. More importantly, the 3D diagram is harder to parse for anyone looking to re-implement the model. Most (but not all) of the information is there, but you have to work for it. With the 2D diagram, the architecture is fully specified and, I believe, very easy to read (though I'm open to feedback). It's not as pretty, but ease of manual creation and the boost in clarity are more important.

NN-SVG looks like a better UI around a beautiful parametrized isometric 3D architecture diagram generator, but it also looks like it suffers from the drawbacks I have experienced in the past. Can it handle residual or skip connections? How easy is it to modify? If you are creating publication-quality architecture diagrams daily, automating it may save you time, but if you've gotta write a bunch of code every time your model's components are tweaked and only need pretty diagrams once and a while, you might be better off doing it by hand. Moreover, whether you use a 3D or 2D diagram, I think it's worth favoring a format that aids reproducibility.
Bitcoin couldn't even change a constant which would allow the system to actually be used for a slightly more reasonable number of transactions…

Lightning took care of increasing the number of transactions Bitcoin can handle. Apparently the folks who wanted to keep the block size the same won; the Bitcoin cash is essentially worthless now. Meanwhile, Lightning is doing great: https://bitcoinvisuals.com/lightning

Why do you think it can do a more fundamental change?

Because there's $300+ billion at stake, which could be at risk with quantum computers in the future. It's already being planed for.
Is the pattern of putting the publish year when it’s not the current year still used on HN? If so, I think this needs a (2007) or (2014) suffix.
What about context sensitive languages like VHDL?
With regards to mRNA, mRNA is a fragile molecule that is quickly broken down inside the body after injection, so there's unlikely to be much long term risk with mRNA itself.
Messenger API Updates for Europe
"All warfare is based on deception."

- Sun Tzu, 5th century BC
Germany is planning to start vaccinations in December too, it's probably a matter of days before the vaccine gets approval in Germany.
A simple launcher for running Windows 10 ARM VM using QEMU on Apple Silicon
Nice food for thought. For those like me that read the comments first:

"To sum up:

If a function is only called from a single place, consider inlining it.

If a function is called from multiple places, see if it is possible to arrange for the work to be done in a single place, perhaps with flags, and inline that.

If there are multiple versions of a function, consider making a single function with more, possibly defaulted, parameters.

If the work is close to purely functional, with few references to global state, try to make it completely functional.

Try to use const on both parameters and functions when the function really must be used in multiple places.

Minimize control flow complexity and "area under ifs", favoring consistent execution paths and times over "optimally" avoiding unnecessary work.

Discussion?

John Carmack"
It's undefined in the C standard. That doesn't mean its insecure or undefined as seen from the machine code. nothin is hilding you back to do your own code generation and clearly define this behaviour.
We Rewrote Everything in $Hotlang, and our Startup Still Failed
Location: Zurich, Switzerland

Remote: Yes

Willing to relocate: Dubai, Singapore, New York City, London

Technologies: Cybersercurity

Resume CV: Cybersecurity CTO, 20y experience

email: on request.
Amazing that people will be getting vaccinated against coronavirus before the year is out.

Is there any evidence of whether these vaccines prevent transmission of the virus yet? Or so far do we just know that they protect the person who is vaccinated?
All these companies trying to innovate on email by making user interface tweaks should really re-adjust their priorities.

Email at its core is a protocol. That's great. But we haven't achieved widespread encryption within the network (e.g. gmail reads everyone's emails).

That's the user experience problem that needs solving. Everything else is just adding complexity to something that works well anyways.
looking for an internship
as a node js backend devoloper
My understanding is that they've been carrying out a rolling evaluation that has been going on for the duration of the trials, which has helped accelerate the normal process.

Having said that, I believe the EMA (EU) also carried out a rolling evaluation, so I'm not sure what the differences are there.
Your answer is phrased in such a way that I can't help but ask: What about the other molecules in the vaccine?

Are there any notable helpers or adjuvants or preservatives?
if your bitcoins are on the next exchange to disappear without a trace.

Anyone with a significant amount of Bitcoin self-custodies and uses at least one hardware wallet to store their Bitcoin.
Norwegian Gov makes IPv6 mandatory in new regulation for government networks
Unlikely to be the latter, because they've already prepurchased millions of doses. Unlikely to be the former either. The UK regulatory system is highly-regarded, and until January the EU medicines regulator was based in London. It may just be that they're particularly efficient.
It's possible with Kobo too, as I recall.
A useful rule of thumb: never depend on character width, unless you’re dealing with ASCII in monospace. Especially once you’re dealing with emoji, also get used to the fact that there will be very wide variation, including that some devices simply won’t have a font that can represent your text, especially newer emoji.
I don't understand, it seems like "securities lending" [1] is designed for the sole purpose of allowing this kind of speculation ("short selling").

Is there any other reason one would borrow securities?

1: https://en.wikipedia.org/wiki/Securities_lending
The universal gifts you mention are all consumable. This is good; it's the Japanese style of gift-giving. Give something nice, luxurious, and consumable.

Fancy fruit/chocolate? Delightful to receive, and completely gone from your inventory without any feelings of guilt after consumption.

Fancy spirit/wine/beer? Ditto (only applicable if you know the person consumes alcohol and isn't a problem drinker of course).
I read that the approval process might take until end of December and that first vaccinations for people at risk and system-relevant groups was expected for beginning of January.

Source (german):

"Bund und Länder stellen sich darauf ein, dass "bei bestmöglichem Verlauf" noch im Dezember mit ersten Impfstoff-Lieferungen gerechnet werden kann. Gesundheitsminister Jens Spahn sagte heute im Deutschlandfunk, dass Anfang Januar die Ersten aus den Risikogruppen und auch schon Pflegebeschäftigte geimpft sein könnten.", https://www.tagesschau.de/inland/faq-corona-impfstoff-105.ht... , 1. Dezember 2020, 11:00 Uhr
iPhone zero-click Wi-Fi exploit
Maybe now we can be?
It's straightforward to create new accounts everywhere, including in GMail. Why to single out ProtonMail then?

Personally I have been approached by fraudsters and their email was on GMail, not ProtonMail...
In case anyone is looking, here is a Christmas tape to get you in the mood. It even includes the ads!

https://archive.org/details/KmartDecember1992
Pick a charity or ask them to pick one to give in your honor.

Or ask for some food you like.

Or anything you can exchange locally at a store you like.