skysight-inc/HackerNews huggingface dataset:
Even the article admits the data contained therein is more an interesting point than an actual decision criteria for anyone getting married:

>Few couples base their marriage decisions on the tax consequences that may result.

I'm willing to bet the number of 20-somethings that have "tax considerations" deciding their marital status can be measured in basis points. Furthermore, nothing I see there is a "new penalty", while the numbers have varied over time, those rules look to be exactly the same as they were 20 years ago.
It's only a reasonable comparison if we're ignoring a large issue. I've spent the last 5 minutes looking for reports of failures due to tin whiskers, and mostly what I see is trade mag notes and essays from about 15 years ago that anticipate a coming plague of electronics failures from tin whiskers. If you have more info about the scale of the avoidable harm in aggregate, as you put it, I'd love to see it.
To expand on this, after fully reading AlQuraishi's "What Just Happened" post from a couple years ago, was this point that he made;

> I don’t think we would do ourselves a service by not recognizing that what just happened presents a serious indictment of academic science. There are dozens of academic groups, with researchers likely numbering in the (low) hundreds, working on protein structure prediction. We have been working on this problem for decades, with vast expertise built up on both sides of the Atlantic and Pacific, and not insignificant computational resources when measured collectively. For DeepMind’s group of ~10 researchers, with primarily (but certainly not exclusively) ML expertise, to so thoroughly route everyone surely demonstrates the structural inefficiency of academic science. This is not Go, which had a handful of researchers working on the problem, and which had no direct applications beyond the core problem itself. Protein folding is a central problem of biochemistry, with profound implications for the biological and chemical sciences. How can a problem of such vital importance be so badly neglected?

In short, academia got utterly schooled by a small group at Google spending a relatively small dollar amount on compute, using techniques that in hindsight are fairly described as "simplistic". There's no way around it.
AWS Open Sources Graph Notebook
> After hitting the guardrail at about 137mph (220km/h), Grosjean's car ripped in half and then burst into flames—something that hasn't happened for over 30 years. To make matters worse, the front half penetrated between the guardrails that lined this section of track. As crashes go, this one was more reminiscent of the bad-old days of F1, the kind that claimed the lives of drivers like Roger Williamson or Francois Cevert.

This.....just sounds so horrific and a nightmare scenario for the driver. At that speed I wonder how much of a sense a driver has of going through this experience vs it's over in an instant. Overall, it's a testament to engineering, that a person can walk away alive from a crash like this.
"I have an accent" as a kind of shorthand for "I have a non-standard accent" is in theory fine, since most people know what you mean.

The reason I pointed it out, though, is because the reverse direction - "you have an accent, which is why I don't understand you" - especially when directed at actual native speakers implies (even if not intended) some sort of deficiency on the part of the interlocutor.
You've got it backwards. The hostility is a symptom of the policy of not enforcing immigration laws, not the other way around.
There are strong incentives in higher income brackets for tax purposes and such.
In the lower/minimum wage sphere, marriage can have the opposite effect. You can loose access to various government programs such as food stamps because suddenly your family income counts.
I've heard that support for single parents and low earning single parents has been increased in recent decades, which has led to lower rates of marriage and subsequent erosions to the general fabric in that socioeconomic sphere.
Companies want customers, as a business decision is makes sense to require vaccinations because if they check that means governments will let them open.
Ticketmaster wants to get whatever the big name acts are on stage with a full house. If they check vaccination status they can sell out a large auditoriums in February to nurses and a few lucky others. If they wait until governments allow large venues to open up they might be waiting until next fall. That is a large amount of money they are leaving on the table.
Likewise, Quantas flys international to places that lockdown as eliminated covid - if they check vaccine status they can fly anyone in without worry about restrictions.
So it makes business sense.
> It's a shame that the advent of the internet has simultaneously increased your chances of finding someone to play with remotely but, at the same time, [for me anyway] pretty much removed all inclination to do so, as I'd never be sure my opponent wasn't just putting the moves into a computer and playing whatever it told him to play.

Cheaters are ranked way too high to play with us ordinary mortals :D This is mostly a problem with those who are really strong.

On the other hand, people who insist on running out their entire clock when they clearly lost everything moves ago.. those salty people are common at the low ranks :P
By that token so can 20 people working together.
I really interpreted that headline as "found a general solution to the protein-folding question" not as the also interesting but not that much "can be used to solve protein-folding problems".
That's right, it's better.

The old mantra "reduce, re-use, recycle" is in that order because that's the order of "greenness". Recycling should be the last resort.
@piva00

Yes that would be way too late. I am hoping to achieve this by the time I am 32 or 35 at the latest. If I get lucky, by 30.

I won't have enough from career likely by 30, but I should have enough to start some side project that would hopefully garner enough passive income.
If you're looking for government waste and inefficiency, you'd be better off looking at military spending. That's where a lot of the low-hanging fruit is.
Why wouldn't signal be able to store local data without a phone number? Your argument seems like a red herring.
More background on this fund https://prototypefund.de/en/ https://okfn.de/en/projekte/prototypefund/
> I'll acknowledge that in reality, there are internet routers, industrial machines, and the like that can probably run for decades on the same software revision given enough babysitting and like-replacement of the hardware.

Don't forget every medical lab machine ever made.... some of that stuff is still running windows 95
When I was doing FPGA work Simulink was very handy for plugging together quick signal processing flows. I kind of miss it, but I've moved on to strictly c/c++ embedded work
None of these trials have used a "challenge" design where people were deliberately exposed to the virus. Instead, they vaccinate a ton of people and then let them go about their lives.

Participants' risk of getting COVID shouldn't go up, unless participating in the trial induces them to behave more riskily.
HN Guidelines:

> Please don't use HN primarily for promotion. It's ok to post your own stuff occasionally, but the primary use of the site should be for curiosity.

shadowban plz
Absolutely. I love most Hemingway. "Men Without Women" being my favorite collection. "Banal Story" and "Today is Friday" both very short. And is "A Very Short Story" from another collection is, as the title suggests, very short.

J.D. Salinger's "A Perfect Day for Bananafish" from "Nine Stories" is a good, but dark, introduction to the Glass family, who are the subject of many of his stories.

And a random one I cherish: "Boys" by Rick Moody (https://barringerlit.weebly.com/uploads/1/3/2/6/13263242/boy...)
It's "Elo" (not an acronym). There is the Computer Chess Rating List (https://computerchess.org.uk/ccrl/4040/rating_list_all.html) which has the current rating, on some predefined hardware.

The easiest way to do what you're discussing is just giving less evaluation time to the engine - slowly increasing it. If you wanted it to be even better you could calibrate multiple engines to make an even smoother (but changing underlying evaluation).
NewPipe is okay but I prefer Vanced Youtube
Does this produce the various different foldings that each protein can often "sit" in?

Can it take temperature and other environmental conditions into account?

Can you specify that a particular ligand or electrical current is present so that you can see the resultant shape change?

Is all the source code for this available so that other scientists can build on top of this, or will we have to go through a paid or SaaS google API to use it?
I have used Bitcoin to send money internationally. I did not spend any money on turning my dollars into bitcoin, because I already had bitcoin. I did not pay $90 in electricity costs, it seems a little silly to bring the block reward up. You already have a good argument for what you're trying to say, you don't need to pretend that a cost others pay is a cost the transaction sender pays. As far as I know the recipients of my transactions did not pay any fees to convert the bitcoin back into their local currencies, because they were fine with holding on to it as Bitcoin.

I am not trying to say that Bitcoin solves every problem. I agree with you that there are many problems it does not solve. The $399 number is disingenuous though, you're ignoring that there are situations where bitcoin really does have lower fees than the alternatives.
Practically there is little difference if all you're interested in is determining folds from protein sequences.

The difference comes in developing a theory for generalizing the study of protein folding as a scientific pursuit.
Modified Bricks Can House Energy, Too
A high performance open source oscilloscope
“an emulator is hardware or software that enables one computer system (called the host) to behave like another computer system” (Wikipedia).

This is not the case for Rosetta 2, which does a translation pass before running the generated ARM binary. No x86 code is run.
Bitcoin isn’t an asset class
What amazed me most was that they used hundreds of millions of unlabelled protein scans. This means we can collect massive data in a new modality, besides the usual suspects: images, video, audio, text, lidar and sensors. Soon I expect neural implant data to be massive as well.

They surely did unsupervised training on raw data and then fine-tuning on the 170K labelled sequences. I expect the data volume could be increased by orders of magnitude in the next couple of years and we'll see a GPT-3 like jump.
Could you please stop posting unsubstantive and/or flamebait comments to HN?

https://news.ycombinator.com/newsguidelines.html
Yeah, I think you make some great points and I'll give you that; you probably did show here why my idea is not correct. I don't know the right answer, I'm certainly no lawyer ;)

I just know that, to me, "dynamic linking" seems like an arbitrary and imprecise way to define "derivative work". And, I'm not sure whether it's really something that _can_ be defined and possible to determine without consider it on a case by case basis. It's a good "right hand rule", perhaps, but doesn't strike me as either necessary or sufficient to really define it. We'll never really know, I guess, until someone makes that actual argument in court.
Cool!

The Examples tab shows the same 2 examples repeated, at least for me it does.
Because that is the definition of a game. A toy is not a game.
So having written production Erlang, I have literally never had an issue with large amounts of problematic mails in the mailbox. It's like, yeah, technically it's possible, since there's no forced constraints around what kinds of messages a given process can be sent (which is intentional; after all, the process may enter a later receive statement that knows how to handle those kinds of messages), but it's really easy to do correctly. And you can always program defensively if you want to limit the kinds of messages you respond to by having a wildcard pattern match at the end of a receive.
Photos from inside the Venezuelan military cryptocurrency mine at Fuerte Tiuna
Archaeologists Are Using Deep Learning C.N.Ns to Dig Deeper
We’re expecting number three in August. FWIW, number two was a lot easier for us.
I think you only perceive “incongruence” because of internalized biases you hold.

With respect to other examples, listen to recordings of NASA flight control, especially from the early days of the Space program. I acknowledge that a lot of what you will hear is Texan and not strictly “Southern,” although that itself can be broken down regionally as well. Recordings of engineers at Huntsville US Space and Rocket center also feature Alabaman and other Southern accents.
Ethereum Staking on Coinbase
Maybe I am weird, but I've had far more problems with anaconda and its package management than I ever have with pip. Conda routinely takes hours to resolve whatever unholy issues it's running into sometimes
"Pedantry" implies that the distinction is not meaningful.

This is true if you're only paying attention to how this system can be utilized to answer questions posed to it.

This achievement by itself, however, does not do much to push the science of protein folding much further. Those advances will come when people poke, prod, and break the model to develop a unified theory for protein folding.
Bitcoin Hits New Record, This Time with Less Talk of a Bubble
What's irresponsible about healthy, low risk individuals waiting until all of the high risk people get the vaccines first?

If there's autoimmune issues that pop up when the scale goes from tens of thousands to hundreds of millions, I'll know about it ahead of time and be able to take the appropriate action, such as choosing a non-mRNA vaccine such as the adenovirus type from Astrazeneca.
Newsletters on any site are prime candidates for spammers and malware distributors. One email reaching thousands or potentially hundreds of thousands of people is very tempting. Spammers and malware authors are getting more clever too. They have bots that pose as people and ask naive leading questions, then ultimately direct people to the watering holes.
A number of fact checks just amount to "don't say it like that, say it in a way that supports our narrative instead" when there's no factual error. E.G:

https://i.imgur.com/EmalFyS.png
https://i.imgur.com/bBCOXzv.png
https://i.imgur.com/UZam8qQ.png

In cases of no evidence, they'll usually rule favorably if it's a narrative they like. Such as here with "Unproven, but alludes to a deeper truth":

https://i.imgur.com/heDavN2.png

Compared that to consistently rating Trump's claims as "Pants on fire" for lack of evidence, or "Mostly False" even when they found strong supporting evidence:

https://i.imgur.com/gATj4Kt.png

There's many topics which, even if I agree with the writer, should be in the realm of an article or opinion piece rather than a fact check (E.G: "AP FACT CHECK: Trump distorts record; BLM falsely accused of coordinating violent protests"). Fact checks should ideally stick to debunking falsifiable claims, rather than providing a counterargument for/against a large political issue.
Solving protein folding has significant implications for medicine and drug development. If they can reverse the process (i.e., go from a desired 3D structure to an optimal 1D sequence), it will open up even more doors.
>InteractiveBrokers allows you to exchange at market rates on the multi trillion dollar forex market for 2/10ths of a basis point ($20 per million).

but that only covers conversion, right? Or does IB also allow you to send to arbitrary accounts?

>therefore you need to pay a 1-2% fee at origin [...] and a 1-2% fee at destination.

That's only if you use the managed exchange service. If use the trading interface (ie. placing bids/asks manually), it's much lower. eg. 0.5% for coinbase pro[1], 0.25% for gemini activetrader[2]

[1] https://help.coinbase.com/en/pro/trading-and-funding/trading...

[2] https://gemini.com/fees/activetrader-fee-schedule#section-ac...
> It's a pretty universal sentiment that what makes people happy is actually close relationships, friendships, family and helping others.

There isn't one path to happiness. Yes, close relationships and helping others in close proximity can feel good. So can wealth, social status, or building a business that positively impacts millions of people. It depends on your values, and your ability to align your actions with your values.

> People like her and even the greatest in the field, like Steve Jobs, may lead extraordinary lives in our imaginations, but inside, they almost always feel horrible most of the time.

I believe you are actually the one romanticizing here. Most people do not have this type of success, and therefore, tend to discredit the lives of those that do in order to protect their self-image.

The story of the outwardly successful CEO who is inwardly emotional distraught is a great Hollywood story, but it's an exception. If you actually follow the lives of most successful entrepreneurs, I think you will find that they are quite happy - enjoying their wealth and social status in their free time.

Yes, the day to day work of a CEO is very stressful. But, when they have time to step back from it all, knowing that they gave it their all and made an impact can be deeply satisfying.

Again, the key is to not assume everyone shares the same values. Family and friendships are one thing to value. Impact, contribution, wealth, and social status are other values. No value system is better or worse, objectively -- as long as you are capable of fulfilling your values.
Some weeks are more tiring than others
The JS ecosystem has just as many "issues" if you look at it objectively. Don't mean to be funny or lazy, but one need only look at this SO answer to see how weird/fragmented the JS package system is (the answer has a Table of Contents).

https://stackoverflow.com/a/39825582/1140382
I agree. I think a company that is working on large scale automated bio experiments would be well positioned to take advantage of something like this.

What companies are doing that work?
Taking "20 GOTO 10" to an entirely new level. Well played, Owlet.
You can already send money from US to Venezuela using Moneygram and several other services cheaply. There are relatively few countries where sanctions prohibit Americans from sending money, and cryptocurrency would not make this legal.
A bit of feedback on accessibility. By the looks of your demo page, you're not using the 'for' attribute to associate form labels to their fields. This makes the forms very difficult to use for users of assistive tech, including screen readers. Screen readers read out the appropriate label when an input gets focus, but without the 'for' attribute it has no way of knowing which label is intended for which input.
I think the video I linked in this thread touches on that detail as well, though I don't remember specifically or have a time index for you. Give it a watch though.
Now I'm just waiting to see who is going to buy Zoom.
I tried the new version of pip and it's giving clear error messages when there are incompatibilities between versions. That should make your life easier.
Microsoft files patent to record and score meetings on body language
True, people debate on these little details and none of them matter, they will be solved one way or another. It's guaranteed that cryptocurrencies are here to stay. Most people don't understand that cryptos in their current form is just the base and when more and more money start building on top of it that's when we will see the real internet 3.0 and all the amazing things you can do with it. It takes some imagination to see what's possible.
Vishwanath Anand did the same for chess in India when he was number one for about a year.
My understanding is, that it's always 100 new structures, which is a small fraction of the total structures identified in that year.

The reason why the top score in one year, can be lower than in the previous year, is that the test (the 100 structures to guess) is always new and different, so it can end up being 'harder' than the year before. Luck will also play a small role.

Another explanation for a reduction in the top score would be, that previous winners are not re-submitted unchanged. For instance AlphaFold v1 seems to not have been submitted to the latest competition.
What is to replace Mr. Fidget spinner "I'm cool like you kids" Pai?
And there is an argument to disable the check.
Increased cyber-biosecurity for DNA synthesis
You don't generally look at neural network output like that.

There is generally a threshold, less than X, not the class, equal or more, is the class. Then you run the network with the same threshold on a known data set and compute a confusion matrix, which tells you about the error, I don't even want to know what a confusion matrix analogue for 3D geometry would look like but I'm sure they have something.

This is literally the process that one does in taking part of the this. And the error rate (specifically the lack of errors) is what is everybody is talking about. 90 is just as accurate as we can get with experimental measurement. It's likely at this point the source of error is in the data set (we can only train on data we experimentally measure and these are not perfect measurements). It's also possible, at this point, the model generalized so well that when it deviates from experimental measurements it's actually correct and the experimental value was the one that was wrong.

So no, the outstanding question is not "is going to be how good is the confidence metric at telling the user to trust or not trust the results.". Nobody is going to be looking confidence values when it model is giving an output, they are going to be looking at the overall error rate across a broad spectrum of proteins to get a sense of it's accuracy.
This is an internalized bias many hold (I am not criticizing you personally, really just making a diagnostic and/or societal observation).

Anecdote:
I know an executive at a major US biotech originally hailing from South Carolina who dials up the Southern accent to 11 when discussing science in order to mess with people’s heads
Didnt say so but if we compare stocks to cryptos i think there is a clear winner
I’m surprised they so clearly copied Apple’s letter to IBM, which turned out to be a letter to Microsoft. We know how that turned out in the 80s and 90s.

https://www.historyvshollywood.com/reelfaces/jobs-apple-welc...
Marriage does not mean both couples will be working.

Conversely, you don't need to be married to be in a relationship with two incomes.
This is also true for a huge number of apple species. Also,'cider apple' generally refers to apples that aren't that great for fresh eating but processing into pies/cider/juices. This is a pretty goofy story to make international news.
The US is a gerontocracy. We are going to end up exactly like Japan, a whole generation of young people passing on kids due to economic and environmental stress with no-one to replace them.

The stats tell the story. Young people are the largest part of the workforce[0], but we work for lower wages and have a TINY amount of the wealth in comparison to older generations[1].

The number of my friends who are hamstrung by massive student loan debt is sickening. The US is bleeding my generation dry.

0: https://www.pewresearch.org/fact-tank/2018/04/11/millennials...

1: https://www.businessinsider.com/millennials-versus-boomers-w...
Thanks for the details, I think this should be properly investigated, and if you find any request to telemetry services in Tor Browser, your findings should be made public.