skysight-inc/HackerNews huggingface dataset:
Two of the first, back in 1999 [1], were Zanamivir and Oseltamivir (Tamiflu). Influenza neuraminidase inhibitors. Researchers examined a structure of neuraminidase co-crystallized with its substrate and designed a sialic acid paralog that was designed to bind with residues that are more conserved across different known sequences of influenza.

I found a recent review with some others listed here [2]. It has a nice overview of the process too!

Forgot to answer your other questions. I'm not up to date on the structure-based drug design workflow but back when I did similar work (5 years ago) there definitely were rudimentary systems for generating molecules and docking them. It may have improved significantly since then. But I would probably characterize it as a problem it itself for sure.

Your other question is a VERY good one. Proteins usually fold into whatever may be most favorable based on the sequence, and it mostly stays consistent once it does. However, they are very flexible and structures solved by EM or x-ray crystallography are like a photograph of bird flapping its wings: you will see the wings in a position, and if you happen to have a few birds in the photograph, you might get a sense of where those wings can move to, but it's never going to be perfect. But like wings, proteins usually still have a limited amount of movement. There are other types that are much harder to understand that have less structure, but globular proteins that bind to drugs like this are usually pretty well-predicted by the snapshots we can get.

[1] https://pubmed.ncbi.nlm.nih.gov/10480735/

[2] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6601033/
What bugs me most is the use of long-living plastics in fast moving consumer goods.
I have to buy 12g of plastics to get 80g of Prosciutto.
From packaging to EOL its lifespan is max. 60 days, most of the time more like 20 days I suspect.
Why does it need to be in a container that degrades in 300+ years?
What do you mean ? You can get the same core design in 4 core and 64 core part with ryzen for example - the difference is price and power.

Single core performance is critical and core count has rapidly diminishing returns for the majority of everyday tasks (Amdahl's law and all that).

When you have independent tasks that need to run massively parallel you are better off using a different architecture because you can get better value from simpler compute units.
Your theory is sound. ;)
If you actually mean stay awake, I highly recommend getting more sleep. Losing interest or zoning out is one thing, actually falling asleep is not a problem with the language or being remote.
Well, I have a cynical take about the unique appeal of Common Lisp, but even cynicism aside Common Lisp is not going to lose to Racket in the "interesting companies" department, I think. Google Flights is still powered by Common Lisp. Clasp is somewhat interesting (and there is a Google Tech Talk about it, too). And instead of learning "How to Design Programs" from people with unclear experience in designing interesting programs, you can read a book full of small interesting programs written by someone with pretty clear track record of doing interesting things (https://github.com/norvig/paip-lisp).
They could start with the 757, it doesn't have to be a completely new design, wikipedia suggests they are looking at this.
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What do you want your camera to understand if it can understand everything?
I'm thinking over the question how broad computer vision can be applied. Or whether it is more valuable within certain fields. So, I'd like to know what's your imagination about it. If your phone camera can recognize anything and give you information about it, what do you want it to be?

Let's limit within object recognition only, for the sake of simplicity. A few examples are coffee beans, plant diseases, knitting styles.
A simple example would be mostly running Linux applications on Linux machines (= containers), but having a Windows application that needs to run in a Windows VM on a Linux machine (VM, or a container in a VM).
The comments here are disheartening, essentially a combination of “It was Google’s right to fire her” and “She seemed ‘difficult.’” For an industry-operated “Ethics in AI” group to have any teeth, it can’t fire people when they do research that makes them look bad, or when members of the group are ‘difficult.’ (Multiple members of the team she managed have said that she was a great manager and this came as a total surprise [1, 2, 3, 4, 5]; so it’s also worth asking who she was causing difficulties for... and whether it was her, or just her research.) Google can’t have it both ways: it can’t credibly claim to be home to meaningful research about AI ethics, but not provide the tenure-like academic freedom protections that enable researchers in universities to discover and publicize results without regard for whether they paint a company’s products or direction in a bad light.

[1] https://twitter.com/negar_rz/status/1334369747241218050
[2] https://twitter.com/dylnbkr/status/1334395186705702913
[3] https://twitter.com/L_badikho/status/1334393782310227970
[4] https://twitter.com/alexhanna/status/1334348137616568321
[5] https://twitter.com/dylnbkr/status/1334372430437994500
Docker community all hands is happening next Thursday 8 AM PST
What's new in Svelte (Dec 2020)
Well, depending on how fast it would spread, we might have enough time to replace things with not-yet-rottable materials.
... why not?
It probably sounds petty, but I found it disturbing that inputs are at the bottom ... I was constantly having to readjust my thinking, and have become sufficiently frustrated to give up.
Reminds me of recon sentinel https://www.reconsentinel.com , destined to $10 amazon clearance near you in a year.

>I purchased two of these when they were $7.99 on Amazon.

https://hackaday.com/2020/11/16/teardown-recon-sentinel/
True on one hand, but we should not make the mistake and place kids in completely surveilled child pen that only fills parents with delight.

How old were you when you started to dabble with computers? And was anything made specifically for you being a child?

I fear kids these days use mostly closed systems so the option to dabble is as hidden as it gets.
For those unfamiliar with the case: Boeing and McDonnell-Douglass actually merged, but the name stayed Boeing. It is often said in the industry that McDonnell-Douglass bought Boeing with Boeing's own money.

The company that today uses the name Boeing looks, acts, and quacks a lot more like 1970s-1995 MD did, than 1970s-1995 Boeing did.
Oh my god, are you right. But they do weather away but at a much slower rate, they do turn into sand.
Not a huge fan of these riscv posts.

This one is more marketing than a technical post worthy of HN.
this is pretty common in pentesting to get a reverse shell from a system with minimal capabilities

https://github.com/swisskyrepo/PayloadsAllTheThings/blob/mas...
voted with your spend

you ensured more plastic bits

is now in your karma
“Perfect Goal Setting Trick Explained in Easy Manner
> You lose your personal tax allowance just above, so there's a dead zone around there. That's my guess anyway, what's the point of your employer paying 100% tax?

It's tapered from 100 to 125k, but at no point is your employer paying 100% tax. From 100 to 125k, your marginal tax rate is ~60%, but drops after that point.

> £500k as a salary is rare, most comp at that level is some sort of bonus.

Even with bonuses, or RSU/some other form of shares, I think "rare" is understating it, and that's exactly the point. The discussion in this thread is that the top performers in FAANG are clearing _well_ above these values (multiples of these numbers).

> once they are familiar with the person will bump the rate to whatever.

Can you be a little more clear with the "whatever" number? 100k? 500k? 1m?
Care to explain your issues with CSS in detail? I agree it's Stockholm's, but just never can't even begin to state all the things that are wrong with it without sinking into Tech Tourette (ok for me the original sin is that it started by redundantly defining properties and syntax when we had this already in the form of HTML attributes; in which world did that ever make sense?)
> But when I saw it boot nearly instantly instead of the five seconds it took to Firefox, I immediately switched and never looked back.
Chrome didn't beat Firefox just because it was faster. It got popular because it was promoted on a Google's home page and google products that were used by million users already.
I skip publications and enjoy reading dev blogs, or at least blogs where I can tell there are no content marketers behind.
That was the price I paid for an Asus 1215B with Linux pre-installed, nowadays still working maxed out to 8GB and having an SSD.
My office allows the standard iPhone apps to connect to Exchsnge. I don’t see a profile installed on the phone. As far as I can tell, the only change is a required PIN (which I would have anyways).
Screw you SA for blasting an ad at my sleeping family at 7 am
The impression I have is that people are miserable because (a) higher unemployment and fear of unemployment, and (b) limited social opportunities because anywhere with people in it has been closed — not specifically because of the lack of flights or commuting.

(Also, most factories are still running; for example in the USA, 16% down between Feb and April and 5.6% down between Feb and Oct [0], which is still almost all being open even in the worst periods).

Much as I like international travel (and despite my mother moving to an Alzheimer’s care home in a country I don’t live in), not flying this year is really low on the list of things that have been troubling me.

I believe human nature will probably cause geo-engineering to backfire; I anticipate a politician will claim that it is pointless and the running costs are too expensive, cancel funding, and proclaim loudly that the lack of immediate severe negative consequence “proves this was the right decision” in much the same way that current politicians who do not wish to spend money on improving the climate make similar claims about winter.

I’m in favour of renewables + storage + global power grid.

[0] https://www.federalreserve.gov/releases/g17/current/
Looks like a good position. He did software for the SpaceX rockets and Dragon as well.
Interesting opinion, since the most recent info to come out of coinbase is that the SJWs were right and upper management are unconscionable assholes. (Oh yeah, let me see now.... they are 'on the spectrum', which is I guess what we white males need to say to excuse our anti-social or racist behavior.)
...and then we're back to square one...
> echo "text!" > /dev/$PROTO/$HOST/$PORT

This being a bash-ism is really misleading. This looks as if my computer has device nodes for $PROTO, and I suppose that's not the case. I think it would make more sense as (optional) /dev nodes giving all programs access to it.
I'd imagine much of the top performer work at FAANG (like the OP's post here) isn't overly exciting either!

> but it is extremely rare.

I'd expect so, and it seems this is rare in the US too, (this is literally the top of top performers at the top companies), but you'd expect to have _some_ indication of this information leakign out.

> Most of the >£100k permanent (not contract) jobs I see have "Architect" in the title which typically means not just coding.

Any idea on the 500k+ roles? (e.g. this post).
It's a nonsense thing but, hey, it's easier than doing something of actual value.
Linters as a Learning Tool
> http/2 and up you speak of, I know only a single F/OSS one (ng-http2) actually used in server-side production.

I can think of, like, five off the top of my head (mod_http2, nginx, h2o/quicly, about a million go apps that use http2, Rust has a production HTTP/2 implementation or three, and Microsoft/Apple's implementations if you want ones on the client side.) It's not anyone's fault but your own if you can't look it up. There are 23 implementations in the QUIC interop matrix which are cross tested against each other as of now, too, and it wasn't hard to find: https://docs.google.com/spreadsheets/d/1D0tW89vOoaScs3IY9RGC... and several of those stacks also implement HTTP/2 as well.

It's not like the internet was some rosy garden in the HTTP/1.1 era where everything was magical and democratic and perfect. HTTP/1.1 is easy to implement wrong, and most people just used stock HTTP servers to front their application anyway regardless of the actual protocol spoken to the end user, which is how it's always been.

Besides, you don't have to actually have to be a megacorp to see the benefit of HTTP/2 or QUIC, you can just... try using your imagination. I have an actual real workload where I want to fetch potentially hundreds of metadata files from an HTTP server. HTTP/2 is a dramatic performance boost for workloads like this. It's not rocket science to see why, despite people wringing their hands about opening multiple parallel connections, etc.

> Similarly, F/OSS was too ubiquitous so we had to invent "the cloud".

You've got a lot of things very confused in your head, it seems. FOSS was never "ubiquitous" until recently, and it was only allowed that status because corporations decided they could make more money with it. They can also make money with proprietary software, so they do that too when possible. You seem to be implying the rise of FOSS was some kind of "outsider threat" to the system which needed to be suppressed, lest it make things "too good for us", and so it was then tragically coopted by Google. No, it was not; FOSS as a movement was always a captive animal from the very beginning and its viability was always at the mercy of corporations with mass market penetration and reach, not the other way around. It's not surprising it took off; it turns out "Don't pay people for their work and keep all the profits for yourself" is a tried-and-true corporate tactic for making money since basically forever.

Not that it's relevant to this thread, but the sooner the free software movement realizes it's completely failed, that it's never even truly had a chance at success, the sooner it'll be able to actually succeed at something.
In case someone doesn't know, that title is a play on the album of Sex Pistols.
unfortunately sometimes wax paper is proposed as an alternative but although the name suggests it to be ecologically it isn't. most, if not all, "wax papers" use paraffin instead of wax
Herein lies the problem with Boeing.

Trust takes a long time to build, and minutes to loose. Boeing knows that, that is how a pilot's license is issued and revoked as well. They gambled their Trust and lost, so now they are in a well-deserved decades-long Trust deficit.
Spot on!

It's obvious that a 10x smaller human population would have a 10x smaller environmental impact (assuming the same behaviors and lifestyle)

However, what is killing us is overproduction, overconsumption and a whole economic model devoid of sustainability goals.

"Overpopulation" is used by some people as a diversion tactic.
You have no idea what you're talking about. The inability to short bad ideas leads to fraudulent horse shit like Theranos or Bernie Madoff. There are entire short-only hedge funds designed to make a profit while leading to more honesty in financial reporting: there needs to be more rather than less of this.
Just recently watched a movie last week, 'Fantastic Fungi'. It covers some of this, as well as many other interesting (and beautiful) aspects about Mushrooms/Fungi.

Highly, highly suggested.

"Fantastic Fungi" (IMDB link below)

https://www.imdb.com/title/tt8258074/?ref_=fn_al_tt_1
I did too.

And I want to introduce my young children to programming, and also find that there is no obvious good modern starting point. Scratch isn't it. Python isn't it. JavaScript most definitely isn't it.

I'm considering Logo and BASIC -- possibly even a BASIC with line numbers and no multiline procedures/functions. Everything modern has a huge barrier to entry for just-learned-to-read children (and the otherwise uninitiated).

Assembly is easy to grok, but hard to use. Modern stuff is easy to use, but takes a while to grok. BASIC seems to hit the right spot for Beginners (All Symbolic Instruction Code).
That's a very interesting remark.

There is criticism against both communism and capitalism for exactly this notion: that history progresses only with material advancement [1]. For example, one is by Cornelius Castoriadis [2] (fan of communism until he assigned this very notion of endless material growth as core of its shortcomings) and another by Erich Fromm, where in "To Have or to Be" [3] he talks about similar ideas.

[1]: https://en.wikipedia.org/wiki/Historical_materialism

[2]: https://en.wikipedia.org/wiki/Cornelius_Castoriadis#The_imag...

[3]: https://en.wikipedia.org/wiki/To_Have_or_to_Be%3F
Cooling electronics efficiently with graphene-enhanced heat pipes
Is there any reason why energy nations like Saudi Arabia could not compete in green energy?

Sure, they can supply fossil fuels from a bounty more plentiful than other countries. But Asia does not lack lithium or silicon.
We should be able to buy things in bulk and it should be generalized. The norm, not the exception. And if it is not possible to sell stuff that way, then the goods should be forbidden to be sold (with probably some exceptions).
> Matthew Garrett, a senior security researcher at Google

Not fired because that's a real job and not a diversity hire?
Sweeping financial crimes bill to hitch a ride on defense measure
I understand your frustration, but (just to pose some devil's advocate questions), your neighbours' behaviours that you describe probably already are inline with government-mandated changes. Peat is in it's own category, so is neither renewable nor non-renewable according to the Intergovernmental Panel on Climate Change, so that's a useful loophole. If your neighbours' cars are at all recent, there's an excellent chance they are hybrids, which meet all of the stringent emissions regulations.

And as for your energy source - is there anything renewable about powering your house with energy generators manufactured far overseas, using brown coal to fuel that energy-intensive process?
There's a small book called "Errors of Observation and Their Treatment", ISBN 978-94-011-6928-8, which seemed dull in class but it emphasized being able to express and defend a numerical result as x +/- y . I did that thereafter and it made a lot of difference in my understanding of the result. It isn't done by many engineers any more, and I always look with suspicion on results claiming absurd precision. There isn't so much understanding there and people who engage in it are much more likely to submit work with multiple order-of-magnitude errors. They do not -know- the answer, they accept the line on the screen un-critically.
Yes, because Apple provides the platform and you discovered Netflix through the App Store. If it’s a problem you can just not have your app on the store or, as Netflix is doing, not have people sign up via the App Store.

Why shouldn’t Apple get what amounts to a referral fee here?
It's impossible to charge electric vehicles on solar panels.
You charge at night when the panels don't produce and the panels don't have enough capacity to charge the vehicle completely.
So you need huge batteries that will be even more expensive.
> radioactive waste

This one seems over-hyped to me. Some species of fungus have been observed extracting energy from gamma radiation. While incredible, it's roughly similar in principle to the way plants extract energy from visible light. The fungus isn't breaking those radioactive isotopes down into stable isotopes, it's just basking in the glow. Maybe this could have some positive benefits for others, if perhaps layers of fungus grew around radioactive particles, thus somewhat shielding them, but this is a far cry from what the popsci headlines seem to suggest.
You mean like granite?
Point A: Biostarch PLA wastes huge amounts of energy to convert biodegradeable starch in to nominally biodegradeable PLA. It would be better for everyone to (1) move to non single use plastics; or (2) recycle plastic (very problematic and rarely economical); instead of (3) wasting the energy and CO2 to fabricate biostarch PLA just for the option of throwing it away carelessly.

Point B: As I have spent months of time on thermoforming research (just visited 9 machine manufacturers last week and am currently buying a line to produce permanent parts) I will try to raise a few points as to why this plan might also be difficult technically. Many parts are custom produced for specific use cases. Moulds degrade over time and may not produce the same caliber of part early, middle and late run. Some people require different polymers for valid engineering reasons (optical, thermal or structural properties, joining/printing/other post-process compatibility, etc.) Say you have a mould and you use virgin material versus some other material. Polymer selection affects all properties. Thickness affects thermal characteristics and structural properties. Equipment and ambient environment state including thermals, air particulates and humidity, mould state, die state, air pressure, configured cycle time, coolant circuit state, type and care of handling after forming. However, the kicker is food safety (a legal requirement in most markets) - rarely guaranteed outside of purely virgin material (there are exceptions: I believe there is a UK recycler that does it) and food safe material is the dominant single use plastics market.
> videos' size is always ever increasing and is always distributed on HTTP, VR is coming, the default protocol for any Service is _always_ HTTP...

Therein lies the problem. Do we really all have to shoulder youtube's (and porn networks) problems? Especially when yt always sends huge video streams even when you only want music?
But in the other hand it also has a factor that helps us in these trying times. Mindfulness provides us with a means of cultivating greater and more objective awareness of our own emotional landscape, the emotions of others, and of external circumstance.

In doing so, it gives us more choice in how we respond to challenges we may face and the ability to more consciously choose where we place our attention.
A few years ago I made a modular IRC bot using ztcp. Probably comes with a bunch of security holes: https://github.com/tiagoad/zshbot/
I don't know why this is downvoted. I happen to love flying on Boeings, especially the 747. I think that Boeings typically have a higher wing loading than Airbusses, which might be noisier but does handle turbulence better.
Qualcomm Tech Summit 2020: Interview with Alex Katouzian
Plastic weathers away, too. And UV light breaks it down.

People usually talk about shorter timescales when they want plastic to rot.
Because one is a phone and the other is a computer? Or maybe because people want the two devices to be treated differently? Why would they be the same? I can’t install whatever I want on my Sony TV or my car. Why does an iPhone specifically have to do this?
AMD Ryzen 7 5800H 8-Core 16-Thread Cezanne Mobile Zen 3 CPU Benchmarks Leak
The font list is... very impressive.
Lord of the World
Being rich and forward thinking is independent of morals