skysight-inc/HackerNews huggingface dataset:
The problem with ab-initio methods in this context is the sheer number of non-covalent interactions present in these large proteins. A simple protein would require a hybrid quantum mechanic/molecular mechanics simulation to even approximate the vibrational energy required to validate equilibrium.

These proteins are so massive that we often use Daltons [1] as an averaged measure of molecular weight.

Conceptually one of the most promising applications of quantum computing is theoretical chemistry, and we are only now starting to make progress in this avenue [2]. I anticipate it would require quantum computing to explicitly optimise large folded proteins.

1. https://en.m.wikipedia.org/wiki/Dalton_(unit)
2. https://arxiv.org/abs/2004.04174
That blew my mind, too, when one of the astrophysicists at the university I was attending grad school at told me this. He also had a telescope set up with a solar filter so people could look at the sun. It was moderately active at the time, and I saw this cluster of sunspots that looked quite a lot like the Hawaiian islands. He told me the biggest one was much, much larger than the diameter of the Earth, which also blew my mind.

We're actually kind of lucky to have a fairly typical, main sequence star right in our back yard to study.
GP said a bit of a cheat not that it was cheating.

Point is that if you try to run a different OS, it will likely run slower, perhaps significantly slower than running macOS
She can still work on complexes, binding modes, and engineered biomolecules (eg, protein–drug conjugates and antisense oligonucleotide dimers) where the training data isn't really there.
> upon finding out my situation, make it abundantly clear that they would not date me, despite me not asking. I refer to this as "pre-jection."

That sounds awful. How exactly do they go about this?
What settings have been linked to SARS-CoV-2 transmission clusters?
The fact that so many people don't know that cash/fiat is losing value over time makes it somewhat of a problem. Furthermore the creation of cash/fiat creates high benefits to those that benefits from the newly created money first, before the money spreads and devalues its value due to inflation over time.

Inflation vs deflation debate is a complicated one, I don't know which is best in terms of enabling technical progress. One is more short termist, another is more long termist.

But fiat/inflated currencies won't go away. It's just that those kinds of currencies just tends to blow up at some point because of inflation and human nature. It's more than nice to have other options, especially digital. The idea to have some kind of worldwide standard that is open and won't change is also nice.
I don't ever plan on getting it. Not remotely concerned about risks of the vaccine. Or the coronavirus. I have a very negative view of most heavy handed corona policies around the world and see them as a much bigger risk to my well being. Don't want to participate in any of that.

From a game theotetic perspective if most people get the vaccine, you're better off not taking it yourself. And if most don't, I will be happy with that too as a political statement.

For high risk individuals like very old people I wouldn't wait too long if the data is solid.
So it might "be over" for small molecules, but let's see large macromolecules and protein assemblies be predicted
I'd say it's didn't necessarily fail, it was just a bad design. It consisted of steel posts in the ground, with stamped steel sections running horizontally. Grosjean's car got wedged in between two of the horizontal rails. It actually succeeded in stopping the 150 mph car from flying off into the desert. In comparison, a smooth concrete barrier would cause the car to just slide along it (hopefully).
Your statement is true - glass skyscrapers kill more birds than wind turbines.

What if the number of wind turbines was equivalent to the number of glass buildings? Would your statement hold true?

Or, a child comment makes a remark about house-cats killing more birds than wind turbines. What if the number of wind turbines was equivalent to the number of house-cats?

You're not comparing like-to-like. If you're recommending scaling the number of wind turbines greatly (to combat climate change), you should instead consider a metric like ' number of birds killed per turbine per year' like 'number of birds killed per glass building per year' to at least get to the data.
Unlike what has been said on Twitter the answer to why the M1 is fast isn’t due to technical tricks, but due to Apple throwing a lot of hardware at the problem.

The M1 is really wide (8 wide decode) and has a lot of execution units. It has a huge 630 deep reorder buffer to keep them all filled, multiple large caches and a lot of memory bandwidth.

It is just a monster of a chip, well designed balanced and executed.

BTW this isn’t really new. Apple has been making incremental progress year by year on these processor for their A-series chips. Just nobody believed those Geekbench benchmarks showing that in short benchmarks your phone could be faster than your laptop. Well turns out that given the right cooling solution those benchmarks were accurate.

Anandtech has a wonderful deep dive into the processor architecture.

https://www.anandtech.com/show/16226/apple-silicon-m1-a14-de...

Edit: I didn’t mean to disparage Apple or the M1 by saying that Apple threw hardware at the problem. That Apple was able to keep power low with such a wide chip is extremely impressive and speaks to how finely tuned the chip is. I was trying to say that Apple got the results they did the hard way by advancing every aspect of the chip.
Ask that to the guy who did the potato diet and lost 100 pounds https://www.nzherald.co.nz/lifestyle/andrew-taylor-eats-noth...

Or ask fruitarians or vegans who don't exercise and are dangerously underweight.

Also, I don't know. Maybe it's because:

- The body needs fats for more than just the krebs cycle (building hormones and cell walls, namely)

- In low fat diets, the body is starved of this critical macronutrient, so it uses its own stored fat to perform critical functions

Or they're pooping it out for all I know. Chopping off a leg will help you lose weight without "burning" calories.

Either way, the hypothesis that carbohydrates raise blood glucose which raises insulin which tells your endothelial cells to pull in fat for storage and fat cells, and that ketosis puts your body in fat storage release mode, is clearly not the whole picture.
What does "cell" mean in this context?
This is good.

Loved early BBC Micro Bot, then amazing seeing ppl pushing demoscene-level FX on it, but the code's all shrunk & obfuscated, taking away from BASIC spirit: being able to see the sequences & be inspired to learn & create, how BASIC got me in my youth & onwards :)
I have crashed with my cart pretty bad. At some point I realized that I will go off track and looked where it will be going. I remember looking for a way out but then I saw the wall and took my hands off the wheel right before impact. It was over pretty quickly and most what I did was just instincts from driving. Only after the crash I put everything together consciously. I would imagine the same for Grosjean. It’s all automated responses.
Incognito mode of your browser
Whatever works for you! Some people absolutely benefit by having more structure. Others are fine without it.
I think the lesson here is that most of the big data genomic, metabolic, pharmacologic and other research will all be driven by deep learning. The models themselves however require 100+ gpus so we are sort of back in that phase where you need large compute systems to even compete. A single lab will have issues unless they can leverage a cloud and then also get grant funding to spend that money on the cloud compute... which may be difficult b/c its basically a consumable now and you don't have any hardware leftover.
(Washington governor) Inslee announces Covid-19 exposure tool
Diminishing value – Value investing is struggling to remain relevant
Run for office? I prefer the trim tab approach: https://en.wikipedia.org/wiki/Trim_tab#Trim_tab_as_a_metapho...

If Bitcoiners are right, Satoshi has been the trim tab of the century thus far. Time will tell :)
If you look at my comment history and hilarious knee-jerk downvoting of anything remotely critical of the HN hive mind, it should be clear to you that I meant that sarcastically.
Oak surfaces might thwart growth of antibiotic-resistant bacteria
Use an incognito tab
I wondered this as well. Once she was at the top of her game, what would the rest of her life look like?

She could have some rematches with Borgov and other Russian champions, presumably winning most of them and maybe losing a few. And after that? Teach? Go back to drugs? Wait until a new child prodigy can challenge her?
You have to compare it to your risk free return lol
This isn't newsworthy. FCC has 5 members. 3 of them match the party of the sitting president, 2 of them do not. Trump's term ends on January 20th.

People downvoting seem to be missing something. This has been known since Trump lost the election. The FCC chairman (and generally leader of most federal organizaitons) always steps down at the end of the presidential term. The head of NASA is also stepping down then.
I see Apple following the path of Nintendo. They don't need to compete on performance, their users aren't buying for performance. Vertical integration puts you at tremendous risk of falling behind.

The future is keeping Apple "fresh", "cool", etc... While keeping product costs low to compensate for a falling market share.

Really says something that Apple is willing to compromise on long term hardware performance.
Gibson's schtick was always to trade on stereotypes. Charitably, his books were "idea novels" about social forces. None of his characters were ever human.
In plain sight: the ghosts of segregation
Indoor Covid-19 safety model
While their new hardware looks to be great: I will never forgive them for their shitty unusable (unless you put linux on it) $800 minis of the past
That's just signaling; it's a way for enterprises to tell graduates that there's an oversupply for the position they are applying to.
Black Friday payment data reveals rapid growth of buy now, pay later in Europe
When should you timebox your startup?
Countries that didn't enforce strict lockdowns do worse economically

https://www.ineteconomics.org/perspectives/blog/to-save-the-...
They could at significant expense.

But why would they? The users don't buy for performance.
Last month we added 2800, the vast majority automatically derived, though we also prize expert review.

We are thinking of doubling that rate next month.

I'm not sure much can be done about the predominance of certain puzzle types in the very early Rush puzzles. Would you prefer more hung pieces?

But in the later levels, mixing it up by themes/tags is an interesting idea, about which I will make some measurements.
Amazing project, I've been tracking your progress since March :) Product of the day is a great milestone. Good luck with fast growth, your product deserves it :)
A new fast, customizable, and AR-ready 3D viewer for the web
Overfull mailboxes can be problematic even with a wildcard `receive` and can happen if some branch of the control flow is slower than expected. We have some places in our code that essentially do manual mailbox handling by merging similar messages and keeping them in the process state until it's ready to actually handle them.
Given that the individual cores benchmark at the very high end of any core available today, this is almost certainly not significant.

If another OS doesn’t take advantage of the specialized processors, it will run slower, but only on specialized loads.
What made you decide to go open source?
Word Nerd
Today they overdelivered, why is it then so hard to believe they'll meet the expectations of a scaled up SoC? It's guaranteed.
I am curious why they didn’t test everyone. Is it just a cost/test capacity thing? Wouldn’t testing to catch asymptomatic cases increase statistical power to allow the study to yield results sooner with smaller error bars? Also, isn’t preventing asymptomatic cases an important function of the vaccine (to get to herd immunity)?
Look at all of the incredible things that came out of Bell labs during their monopolistic reign. I think a better way to put it is not all monopolies are bad for research and progress but many are bad for other social and economic reasons. Like any position of power, it depends on how it is used snd who is using it.
The art was great and all, but Monkey Island 2 is one of the best written games of all time, IMHO. Just so so good.
And it seems my own submission's taken off despite my noting it was a dupe of this post. Life's not fair ¯\_(ツ)_/¯

https://news.ycombinator.com/item?id=25256605
EU: Council set to adopt declaration against encryption
How to Face a Classification Problem with Scikit-Learn
There's been little out of the FCC that's been supremely bad. People have a completely irrational hatred about this and talking to them is almost impossible. "Vitriol" is an accurate definition of what occurred.
I was interested to learn that the loudest possible sound on Earth would be 194 db. [0] Krakatoa apparently "only" clocked in at 180 db, meaning the loudest possible sound is about 5x louder than said eruption.
It's a movie reference: https://www.youtube.com/watch?v=P_Fr0euKJLI
Is anybody here using one of these for serious development, and can comment on performance? On reddit there are some comments about anything Java-related being rather slow for instance.
Yeah I've been exposed to Pai and the man certainly is more erudite than myself. My view on network neutrality at this point is the companies pushing for those laws were always more of a monopolizing threat than the ISPs ever were. Netflix and Google loved network neutrality because it saved them lots of cash and they ended up getting an "internet fast lane" Comcast couldn't dream of by installing a massive CDN across the globe.

It seemed like policy that was supported mostly because it was pro-consumer and because honestly the ISPs are getting lots of taxpayer money.
Subject reports of exposure are notoriously unreliable. People forget. And even when anonymity is guaranteed they lie about shameful behavior.
Well a lightning channel requires 1 on chain transaction to open and 1 to close so it’d cost $12 and for everyone on earth to open and close a single channel would take over 70 years. So it’s not really a scaling solution. And L2 isn’t blockchain anyways, you could conceivably implement lightning with classical assets.
How do you reach this conclusion? Their individual cores and memory architecture still beat almost everyone else on general purpose loads without any of the specialized engines.
Also being on TSMC5 on top of significant micro architecture improvements ; ~630 instruction deep ROB, ability to queue ~150 outstanding load instruction and ~100 outstanding stores and huge TLBs which reduces swapping the anandtech article does a great job going into explaining this.
Solaris had NeWS, ToolTalk, OpenLook, the only UNIX alternative to Windows IO complementation ports, explored the idea of Java based kernel drivers.

Irix had Inventor.

NeXT had the mach kernel, drivers written in Objective-C, Renderman, EOF, WebObjects, DisplayPostscript.

Ridiculous is putting up with certain clueless people online that don't have any idea of what they are talking about.
They've been sustaining it for many years already, that's how they've gotten to the point of being able to passing up the incumbents. They didn't just start on this path this year, its the culmination of a long play strategy.
Apple has been beating “the big dogs” in performance for years with this processor and OS architecture in mobile & tablet segments. They’re switching laptop and desktop segments to this architecture because the mobile architecture already overtook the big dogs and has been growing the lead for a couple of generations. The A14 phone chip is already faster than most laptop CPUs, just like the A12 phone CPU was faster than most laptop CPUs when it was released.
You're right, I was wrong!
It's hard to find the motivation without the adrenaline rush for many people
How can a vaccine have an adverse effect? Vaccines are safe
Sure, but the Zoom metric is not "Daily Active Users" it is "Daily Active Meeting Participants". They've been very clear that this counts each time a user joins a meeting.

See: https://www.theverge.com/2020/4/30/21242421/zoom-300-million...

(Of course this was all back in April, and especially with their adoption in education maybe they _do_ have 300m DAUs by now - I'm just responding to the metric in the original article.)
They use this one trick that AMD and others hate: they paid TSMC to use up all of their 5nm capacity.
No, but most people can avoid gathering in restaurants, avoiding in-person shopping (All major grocery chains now support curbside pickup, as do many, many smaller businesses), and taking basic safety precautions like not hosting social gatherings, wearing a mask while at work, or in public places.

Instead, what we see is people going to restaurants as soon as they open, packed stores, Thanksgiving dinners with people who don't live in their household, and as of my last walk around the neighborhood, plenty of folks walking around with their noses sticking out above their masks. On the bright side, most of them do seem to have masks.
Block javascript from medium.com
Can you explain how they are ‘compromising on long term performance’?

I don’t see any logic that supports this claim.
Stockfish can play a pretty convincing ~1200-1400uscf game. (At least for that rating range 30 years ago.) It won't start making egregiously dumb moves until it's in the "If I were a person I'd resign, but I'm a computer so here take all of my material before you checkmate me" phase, though many of its opening choices are obviously third- or fourth-best.
the article is short enough that it's just better to read it.
May well be, but if you spend more compute, and human time checking for those corner cases than if you went with another, more consistent exhaustive search algorith, then the method looses to it economically.

This is more the case the more close to bruteforce you come, like encryption cracking. Imagine, spending years of HPC cluster time, trying to break a password, while knowing you have a single digit chance to miss the right key, in a way which would be completely impossible with with a conventional solution.
While the M1 is super impressive, I'm kind of wondering how scalable the performance increases they made here are.

They moved high bandwidth RAM to be shared between the CPU & GPU, but they[1] can't just keep expanding the SoC[2] with ever larger amounts of RAM. At some point they will need external RAM in addition to the on chip RAM. Perhaps they will ship 32GB of onboard memory with external RAM being used as swap? This takes a bit away from the super-efficient design they have currently.

Likewise, putting increasingly larger GPUs onto the SoC is going to be a big challenge for higher performance/ Pro setups.

I think Apple really hit the sweet spot with the M1. I suspect the higher end chips will be faster than their Intel/ AMD counterparts, but they won't blow them out of the water the way the current MacBook Air/ MBP/ mini blow away the ~$700-2,000 PC market.

[1] I updated the text here because I'd originally commented here about the price of RAM which is largely irrelevant to the actual limitations.

[2] As has been pointed out below, the memory is not on the die with the CPU, but is in the same package. Leaving the text above intact.
Why bother? Computing is blazing fast already. Anything that is slow should use multi threading.

There's a reason most computers compromise on the processor performance, we don't need it. Take that extra few hundred and give me more ram and a better video card.
Your question about "forever newbie" is really interesting to me, and I'd love input from people with more experience in software development (15+ years).

Personally, I love the idea of jumping around every 18 months or so to experience new domains, new technologies and learn from new people, but I also worry a lot that this will severely limit my career potential after I've done it for 10-15 years.
Once the technology is actually ready, car manufacturers can request spectrum again. Spectrum should be used, not held in lack of use. There's rules around spectrum that if you don't use it, you lose it.
This is true, I don't have all the facts, but tony was obsessed with candles lately. First hand account says candles + nitrous tank caused the "fire" but it's more likely that he went too hard on the nitrous and was brain starved of oxygen, was on life support for many days braindead before his body went.
It's essentially cultural. A fundamental assumption of the Go language, implementation, libraries, and community is that goroutines share memory. You don't write concurrent Go code assuming that a Goroutine could arbitrarily disappear, so breaking this assumption will break things.

Lunatic is not like that:

> Each Lunatic process gets their own heap, stack and syscalls.

Similarly, Rust code that uses threads and/or async isn't going to work in Lunatic (or at least won't get the advantages of its concurrency model) without being rewritten using Lunatic's concurrency primitives. The concurrency model is more like JavaScript workers or Dart isolates, though hopefully lighter weight.

I'm guessing that the Rust language might work well because move semantics assumes that values that aren't pinned can be moved, and that's a better fit for transmitting messages between processes. But there will probably be a lot of crates that you can't use with Lunatic. If it became popular, it would be forking the community at a pretty low level. You'd have some crates that only work with Lunatic and others that use async or threads.
The fact that credit card fees are high is not reason enough for Bitcoin to win this forever. Nothing stops interchange from switching from a % model technically - the costs to the issuer and the network scale on a txn basis (same as bitcoin). All it takes is banks to cap their interchange - which they can, if bitcoin ever becomes competitive?
so are all these protein folding labs and projects e.g. folding at home, etc essentially dead projects now?
I see two main reasons:

- 5nm process (1.8x the density of 7nm [1])

- unified memory directly on the SoC

[1] https://hexus.net/tech/news/industry/130175-tsmc-5nm-will-im...
> Let me tell you folks. Writing spaghetti code with no separation of concerns and no version control is not exclusive to php

Yowza. If I can give you some unsolicited advice: get some kind of version control in place! Even if it's just a local git repo at first.

There were two things that made working in ColdFusion almost tolerable. (1) The place I worked started using an MVC framework before I left. I was pleasantly surprised by how much it improved the experience. (2) Transitioning to CFScript instead of CFML tags made a big difference as well.

But at the end of the day, it's still ColdFusion, and it drove me bonkers.
Using a JavaScript toggle button also works.
Given that we only know the structure of on the order of 100k proteins, we might only get another 10k new ones per year. I guess.

Using 1% of those (presumably from the more-often-reproduced subset) for this challenge seems reasonable? Note that the structures have to remain secret up until the challenge, and presumably all those teams uncovering the structures don't want to have to wait up to 2 years every time to actually make their results public.
> Just nobody believed those Geekbench benchmarks showing that in short benchmarks your phone could be faster than your laptop.

I saw a paper on (I think?) SMT solvers on iPhone. Turned out to be faster than laptops, I kind of brushed over it as irrelevant at the time.