skysight-inc/HackerNews huggingface dataset:
It's pretty clear what solving means, it means to have an exact representation of the 3D structure. Our partial knowledge obtained from such techniques is what it is, partial. We need new metrology that increase the observability accuracy and completeness OR better deterministic models from sequences.

"We can't know/solve anything beyond our best knowledge, that's tautological." yes it is indeed tautological if you assume that experimental methods can't get better then guess what? It follows that they can't get better!

"what are you basing this on?" on nothing solid, that's why I say it would be interesting.
99% is a non negligible error rate given that proteins have generally a not very high atom count and they the protein will be produced an enormous amount of time, then the 1% error progagate and can a priori easily break the system.
But this guess is not solid as I'm not an expert.
99% accuracy for simple (low atom count) proteins is a sensitive error and could be negligible for very high atom count proteins.
Yes, I expect an ARM MacBook Pro not to be that massively faster in the peak pearformance, but it should run considerably cooler. This means sustained peak performance and overall less fan noise. If I have anything to critisize about the MB Pro, it is that there is just too much fan noise with even not so big loads and the machine just getting very hot. Adding more battery lifetime would also be a welcome improvement.
(Though, 8 high performance cores would also deliver a quite impressive speed)
I think it's more if you want to not send scratch or cached files you can have it automatically remove it from the snapshot being sent

> Redacted send/receive is a three-stage process. First, a clone (or clones) is made of the snapshot to be sent to the target. In this clone (or clones), all unnecessary or unwanted data is removed or modified. This clone is then snapshotted to create the "redaction snapshot" (or snapshots).

Think of it like a selective sync in Dropbox or SyncThing at the FS level.
Why can't they just give the IO bus a slower clock and devote the resources to the memory bus? Or, memory-map everything and make the IO area yet another reserved area the BIOS tells the OS about?
Stocks are only an indication on how the rich are doing.

Why don't you ask the waitress at Denny's who's had her hours cut in half how the S&P 500 affects her?
Alternatively, replace twitter.com in the URL with nitter.net. It points to an alternative client.
Crypto Wallets Are Not Bank Accounts
The charitable reading of that statement is that the fact that it's a medical term is presumed-known, while the fact that the term originated during the Napoleonic wars is presumed-novel.
Cloud costs weigh on Zoom's growth as sales outlook beats estimates
Neat. As a remark, this is how LDAP is structured: entries (files) are "tagged" by attributes (directories) and you access them with the same pseudo-paths which are actually conjunctions of filters.

I must say honestly i'm not so fond of using ordered sequences (posix paths) in place of the unordered sets which they should be. I guess my question is really why you wanted to make a fuse fs out of it (versus say some tag-based filtering script like notmuch). (just for fun is surely a valid answer)
GM scales back partnership with electric truck startup Nikola
With checked exceptions it's not clear how control can pass into the catch block (using Java terminology). The fact that a method can throw a particular exception is not visible at the call site so unless you examine the declaration or definition of every method call within the try block, you cannot be sure from where control can jump to the catch block.

And if there are multiple places within the try block where the caught checked exception can be thrown, then basically the catch block can do nothing sensible with respect to recovery or even guaranteeing anything about the current state of the world once you're in the catch block.

I've seen some horribly ugly patterns used in an attempt to deal with this - basically you need to explicitly record progress within the try block which can be tested in the catch block.

And whatever about Java - at least the design decision hasn't completely poisoned the subsequent development of the language. Whenever I use C++, it feels like a massive amount of the complexity, wizardry and arcane/complex patterns required to write "safe" C++ would not be necessary if they hadn't added exceptions to the language early on.
I’ll leave the above comment intact from here but I already edited once and still regret the word choice “fundamentally incompatible”. As with any data structure, you can make adaptations and accommodations to support use cases that seem to conflict. There’s always a memory/performance/impedance mismatch/experience cost for any abstraction, but there’s no reason a set/tree hybrid couldn’t provide for both families of use cases, given those costs.
I've never been good at chess, nor felt like I was making any progress on paper chess problems. Not that I really tried to solve them.

But lichess training was really engaging for me. I played it for a few hours, and I found the format of the problems and the ui nice in a way that let me solve things pretty quickly. I like that all of them are formatted as "do the best moves", and yet some of them end in checkmate, while others end with just getting a really favorable trade.

It felt like 90% of the plays involved making a check, and then using the forced response to gain an advantage. Is that representative of actual play though? I get that you can't make a deterministic puzzle unless there's a fairly deterministic right answer and path to get there. But what fraction of good chess thinking resembles solving these kinds of puzzles?
> Ringworm is a disease caused by infection of the skin by fungus, appearing as scaly, ring-shaped patches. Fergus Fungal Budge was a wizarding product that was used to treat the ringworm disease on the foot. More at Harry Potter Wiki
De novo design of protein logic gates: https://science.sciencemag.org/content/368/6486/78
I wish we had the option to use web apps instead for native apps for everything. As much as I hate modern web, I can't deny that not only are web apps cross platform, they also offer better privacy.
> crime is really, really bad

Actually violent crime is at an all-time low. See this article about homicides for example: https://www.sfchronicle.com/crime/article/With-41-killings-i...

It looks like you were thinking of property crime, but I wonder what the statistics say about that, too.
I mean that sounds pretty easy to set up on your own. Just some VRML or VRchat plus one of the "pub" discord servers (with VRchat you wouldn't need the discord part.)
Yeah, i imagine sitting out in the sun coding away. With modern laptops, you can't work even with a lamp behind you because of all the reflections.
That's a protocol problem, use a protocol such as rsync. You don't need to use redacted sends/recvs.
Easily possible! Check out the mobileread forums.
The US government has deemed US dollars to be the only thing that can be used to pay taxes, so therefore it has some root value.

This is incorrect. Just because we pay taxes in dollars doesn't give it any intrinsic value. It has been decreed by the US government that we do so but that doesn't change the underlying fact that the dollar is based on… nothing other than a promise of the government that it's useful.

Because more gold can be mined and more dollars can be printed, each block of gold and dollar loses value, because they're not scarce.

A dollar in 1913 had the same buying power as $26 in 2020 [1]. Bitcoin is hard money; it can't be deflated and it can't lose buying power like all fiat currencies do.

[1]: https://www.thebalance.com/what-is-the-value-of-a-dollar-tod...
This is baseless slander.
And even during that 1 hour you are allowed to make your own decisions about... the color of your toothbrush, just to give a stupid example. At work, you can usually only dream about this degree of freedom.
Fair enough. I may have projected a number of other comments onto yours a bit. Sorry about that. If the delta is similar it would certainly be crazy fast.

As far as the packaging, I agree with your general assertion. However, they ship about 20 million computers and about 240 million iOS devices per year, all of which require custom SOC packages. Needless to say, they are a very large customer with their packaging suppliers. I could be wrong, but I think the leverage they get will keep the costs in line even for a smaller slice of their premium priced products.
Is that a... triple negative?

I think you mean senders expect a response?
I didn't realize there were incompatible Morse Code formats. I was hoping to learn Morse this winter, and already started writing a Lisp app to test myself with, but this really turns me off of the idea. I'm quite glad I didn't start and accidentally learn the "wrong" one.

What is the variant typically heard on Short Wave Radio?

PS: Converter is spelled wrong at the top.
You were right, it worked this time.
Sound like a really awful experience, if it happened to you, I’m really sorry! I’m not sure if there’s a definitive answer (in psychology) whether someone has the emotional constitution for management that is set in time; it might be a matter of timing for many people.

In any case, one of the things we try to achieve with our app is to help people in this situation: we have tips for resilience, self discovery and emotional intelligence that can help better handle this emotional rollercoaster.

It turns out that many people get pushed into leading a team a specific way (by their peers, mentors or lack thereof), instead of having the tools to find their own leadership style and learn how to grow it. That was one of the main motivations when we started working on the psychology of our app: we need to start by discovering people’s leadership style, and only then recommend content & tips that will help them on the journey
>But this is exactly a consequence of catering to wealthy tech:

It wasn't tech that passed Prop 13 and imposed permanent austerity and deflationary budgeting on California's local governments.
The nice thing about Apple hardware resale value is that you can just buy now and upgrade later. I just unloaded a five year old MBP for a lot more than I'd ever have gotten for a five year old PC laptop. Ordered myself a fancy new M1 laptop, and if M1X/M2/whatever-it-is-called is substantially better, then I'll just trade it in on a new model. There's always a new hotness coming next year.
I'd love to get rid of my FreeNAS VM and run ZFS directly on my Linux desktop, but having to mess with the kernel has kept me from attempting it so far. Maybe I'm worrying about nothing.

btrfs seems like the main alternative if you want native kernel support, but when I checked a couple years ago there seemed to be a lot of concerns about the stability. Is that still the case?
No. I didn't have the taste and smell sensory symptoms either.

I did have hive like blistering down my left thigh though.
In practice I’m not so sure I think that’s really a concern, especially for a company like Salesforce. They could probably just afford to let it stagnate while they dangle massive salaries in front of the few that could actually maintain the codebase. And it’s not like everyone would leave immediately after the acquisition... but definitely very soon after haha
Good. Riddance. (SF resident of 30 years). I used to lament having to commute 2 hours to SV, but then SV came here, and boy, the City has gone to shit because of it.
> Market cap weighting essentially results in what essentially a momentum overlay: new money is allocated disproportionately to the stocks with the highest market cap, resulting in those stocks going up even more

New money is allocated exactly proportionally to a stock's market cap in a cap-weighted index fund, by definition. New money into such funds can't disproportionally increase the price of one stock in the index versus another.
In a laptop, low thousands might be about right. And for RAM, need captures it pretty well. Either you will once in your life need to do something that uses 256GB ram, in which case you need it, or you don't.
Ah, I was wondering what happened since I stopped hearing about "ZFS on Linux" so now I know what to search for. Thanks!
Just to be a bit pedantic, these aren’t apples and oranges comparisons. It’s common to measure lives lost in quality-of-life adjusted years, since losing an 85-year old to COVID is a lot different than losing a 20-year old to suicide or due to deferred medical treatment. (The ages are exaggerated, but obviously COVID victims tend to be much older.)
8GB MacBook Air can easily handle 4K.

And it can handle 8K for 1-2 streams and starts to lag at 4+.
Who said anything about swing states, and how is an opaque political appointment a democratic way to decide anything?
It doesn't take away from it because it's never been a good argument. x - 0 still equals x.

There are plenty of valid arguments to vaccinate everyone we can.
Weird architectures definitely make the question a lot more difficult to answer. My gut reaction would be to say that your hypothetical ISA has 33 registers, and that the register file is memory-mapped to a specified region of virtual memory. That's partially because of the way that you're going to worry about how cache coherence will work out, but also because I suspect the mcontext_t or OS-equivalent interface will also define its structure layout as such.

The broader point, though, is in deciding whether or not to include registers like CR0 and DR0. The principle I'm using here is that registers that are not expected to be saved/restored on task switches should be excluded. Registers that are per-process (i.e., page tables in general, or segment descriptors on x86) or per-CPU (most MSRs) are thus excluded by this criterion.

FSBASE/GSBASE are extremely borderline--I wouldn't complain if they were or if they weren't excluded from a list of registers. These act as a mixture of user-visible registers (even if accessibly only via syscalls until very recently) and segment descriptor information. They're not in Linux's userspace-visible mcontext_t struct, but they are in the kernel's equivalent to mcontext_t.
All vaccines in the US come with informational sheets that warn of possible dangers. The one I remember is Guillain Barre syndrome.

The risks are low, and the benefits of the vaccine vastly outweigh them.
I want to preface this by saying in no way am I minimizing the stress, strain and pain that goes along with treating COVID patients. But I believe articles like this one do not serve a positive purpose beyond spreading FUD. Let me explain.

First, the author goes straight to the ventilator as a fear tactic. The fact remains, most infected do NOT get hospitalized, most hospitalized patients do NOT require ICU level care, many ICU patients do NOT require invasive ventilation. The author makes it seem like there are no steps between getting COVID-19 and being on an invasive ventilator. We now know[1] that this is not even suggested for most patients.

Secondly, they buried the lede a bit, "ICU beds usually run at about 70-80% capacity.". This is a point that is rarely mentioned, so I am glad this author did. But when you hear pearl-clutching news stories about the local hospital being at 80% capacity, remember that is _normal_. And hospitals can manage surges. It is like when the media focuses on case count rather than death rates or % positive rates. It creates a false sense of fear and panic.

Finally, and this is my biggest problem about this article. We all know COVID-19 is dangerous, deadly etc. The market of emotional COVID hit pieces is saturated. It needs to be accepted that each person assess risk differently. And assessing the risk of COVID and deciding to still go to the gym doesn't mean the person hates science or is a dumb person. It means that they are accepting the risk.

You could (convincingly) argue that in a society, we can't assess risk at the personal level as our very existence risks others. This is a deeply philosophical question, and it lands somewhere between the runaway train thought experiment and the butterfly effect. Somewhere between a direct action resulting in death vs. a serious of consequences in which the end result is the death of someone but you were the prime mover. At which point does the "blame" reduce to 0? I am interested in this debate.

Anyway, stop with the emotional pleas. People know. They simply accept it.

[1]
https://www.statnews.com/2020/04/21/coronavirus-analysis-rec...
Sadly dRAID (parity Declustered RAIDz) just missed the cut-off for 2.0, but it looks like it will be in 2.1:

* https://openzfs.github.io/openzfs-docs/Basic%20Concepts/dRAI...

* https://www.youtube.com/watch?v=jdXOtEF6Fh0
A metrics runbook for dev teams
There isn't any fundamental limit. Threadripper's don't have GPUs taking up space and heat budget though.
I am happy you mention this. I was reading the article and thinking “wow the amount of scientific knowledge these guys need to know to understand what they are doing is way beyond me”. I work in health care and I always talk to clients about all the cool things they witnessed in their life. Cell phones, TVs, microwaves are some obvious ones I like to talk about. I sit and wonder what are the things my generation will get to look back on and say “I was alive when that happened”. I guess for many of us we will talk about how the internet was vs what it surely will be in the future, a shell of its initial glory.
You could encode 16 bytes–there's no need to save a slot for zero.
> Do masks harm? Lol, no.

Well, let's think about it for a second before completely dismissing it. Are there any circumstances where masks could do more harm than good? Well I don't know for sure, but off the top of my head: sharing masks and not washing your masks regularly seem like they could be vectors for infection. Also masks might give you a false sense of security and cause you social distance less frequently than you ought to (for example).
Because by making it a regular fs you immediately get support in every piece of software.

Every file chooser on your system suddenly knows about tags and gives you a way to query them.
I'd be perfectly fine with fully metered data plans at high speed: However, the same group of people who support net neutrality complain that data caps are also unfair. Notice that "unlimited data" is once again, however inaccurate as it is, nearly the only way to buy wireless service in 2020.

I feel a very small group of companies are pushing an incredibly wasteful business model, because they aren't the ones paying for all of the waste. Google, Netflix, Spotify, etc. would rather you wirelessly stream content that makes... a lot more sense to store locally. And they're pushing things like streaming 4K... even when the cost/benefit of streaming 4K to a phone is questionable at best.

We're all paying for the extreme network contention of 90% of available bandwidth going to these very wasteful business models. It's pretty unsurprising ISPs would like to charge extra for them, either towards consumers or the streaming providers themselves.
As others have pointed out, the cost of the mistakes is a rounding error.

If you spend $100M to reduce waste by $34M, then did you actually reduce waste?
I'm not sure if I buy the quality of life argument, at least in the context of the very well-paid tech employees. The "ambient" quality of life in many prominent areas has been fairly abysmal for years (since long before COVID-19) and these well-paid residents simply avoid this by Ubering from one isolated "nice area" to another. I doubt that incrementally less public funding for education, cleaning, homeless, and drug problems is something that most of these well-paid residents would notice. They'll just keep paying to maintain their "nice areas" and Uber from one to the next, just like it has been for the last 9 years I lived in SF.
Also, what do the traffic stats look like for the second/third pages of big threads like this one? Pretty steep falloff?
You know Ubuntu support ZFS since 20.04. Experimental, but quite stable for me. Just select file system during installation process.
I grew up watching the 1984 version of this silent film that was put to 80s music (Freddy Mercury of Queen, Pat Benetar, etc).

Fond memories, thanks to my father.
I didn't, and cannot, downvote. However my BS detector immediately went off when I read the phrase "99.798% of residents in San Francisco County have NOT received a positive COVID-19 test." That percentage doesn't really mean anything in this context. More meaningful might be number of positive test results as compared with total number of tests I suppose.
You aren't wrong. I got caught up making the comparison between structural biologists and taxi drivers being ran out of business by AI, so I ended up exaggerating the work load that's addressed by AlphaFold. I should been more precise.
ISPY1 has four clinical timepoints for BRCa
Escaping is an unnecessary kludge in 99% of cases. If you need nested tables, then you need a special-purpose format that allows for it--and it will very likely look more like a binary filesystem than a parseable text file. If you don't need nested tables, then escaping is unnecessary if the format uses delimiters which aren't present in the data. A lot of data includes newlines, some data includes tab characters, but only binary data would ever include the ASCII specified delimiters.

Don't get caught in the CS trap of thinking you need a completely "general purpose" parser, when a slightly-less-than-completely-general parser will be significantly easier to write, simpler to understand and debug, and faster to execute. And as mentioned above, if you do find yourself needing more than this parser, then you should be looking at non-parsing based approaches anyway.
This, folks, is the root of so many problems.

> When a property developer wants to steamroll the city's zoning and put 200 apartments sharing a fence with people who've maintained the community and lived for decades with 1 or 2 neighbors, that is a big deal.

You and your neighbors own the land you have purchased. Nothing more. You don't get to dictate what others can or cannot do on land that doesn't belong to you. If someone wants to build 200 apartments, it's likely that there is expected demand for those 200 apartments. That's 200 families. So what if they are going to share a fence with you. Buy a bigger plot of land to create a buffer then.

Places change and evolve. You can try to delay things as much as you want, but it's only that, a delay. And ultimately, not up to you.
The short answer is no. Basically, you are asking them to really have two sets of cores on a single die and switch back and forth.

I think the more realistic point of view is that x86 has likely run its course, and now it is time to move on.

The long answer is look up Transmeta and do some reading. Basically they designed a RISC CPU core with an external microcode engine, that was able to run x86 instructions. It was a valiant effort, but it didn't work as well as hoped.

Here is a fun history read that mentions Transmeta as well as P.A.Semi. P.A.Semi is the core team that designed the A1 (and following Apple cores) after being bought by Apple in 2008. Prior to that, the team had designed the DEC Alpha (awesome processor) and StrongARM cores. Later, they developed PowerPC cores. A team with really deep CPU talent, and in particular, prior ARM ISA experience, when they were acquired in 2008.

Sorry, I forgot the link on the first post....

https://www.linleygroup.com/newsletters/newsletter_detail.ph...
House to make historic vote to end marijuana prohibition this week
Having so much money that you've maxed out and over-flowed tax-sheltered accounts—accounts that many people aren't even able to afford—to the point that you're now worrying about tax efficiency is a not a bad situation to be in IMHO.