skysight-inc/HackerNews huggingface dataset:
To understand what's described in this article, it helps to start by understanding how a lateral flow test works: [0]. Basically, the active ingredient in a lateral flow test consists of two components chemically bonded together: a colored material and a chemical that bonds to the thing we're testing for, called the "conjugate".

If the desired material is present in the flowing liquid, the conjugate bonds to the test material, and the entire particle is carried along in the flow of liquid. Then, we look for the presence of the colored material downstream. If the color shows up, the test is positive, if not the test is negative.

The problem that this paper is trying to solve is that previously used colored materials (e.g. tiny particles of gold) can't be detected in very small amounts because the color blends in with the background noise, if there's only a very small amount of it.

These new particles consist of a tiny diamond with a carefully designed irregularity in the crystal structure, where a carbon atom in the diamond is replaced by a nitrogen atom. These diamonds don't just emit a single color of light. Instead, they can emit different colors of light if you shine the right type/amount of microwaves on the diamonds.

As a result, these diamonds don't blend in with the background noise, even at very small amounts, because the background doesn't change color as you shine different microwaves on it.

They were able to detect a concentration of these diamond particles 100,000 times less strong than the prior gold particles. As a result, a test made with these particles can return a positive test result with much smaller amounts of the material being detected in the initial sample.

As an example, the researchers were able to make a test that could detect the presence or absence of single HIV RNA molecule. This test combined a 10 minute chemical treatment step (amplification), followed by a lateral flow test based on these diamond particles and a (previously known) conjugate for the HIV RNA molecule.

[0]: https://en.wikipedia.org/wiki/Lateral_flow_test
It really depends on the edge that needs to be captured. If we're trading a low latency edge in SP500 E-Minis, then not only is C++ better but it might be the only option to successfully capture that edge.

On the other hand it we have some niche edge in a smaller market that's less speed competitive, Java might very well be the better choice given that we might be able to capture that edge with 8us tick to trade latency.

So the answer totally depends on what edge you're trying to capture. There are still a large number of edges where Java is good enough. GC is not really a problem, either using a commercial JVM or coding without much garbage and large memory.
For people to get recommendations of friends, they must have friends using the app, so you have a strong network problem. Facebook solved that restricting the initial users to the students in Harvard. How are you planning to get an initial cluster of users?
>as it was way richer that any other country.

It was also (and arguably still is) way freer that any other country. In terms of freedom of religion, political, and economic freedoms. Its individualist culture is way more conducive to accepting differences, and being an immigrant nation from the start, making it your new home is much more natural.

One country is liberal and democratic, the other one currently keeps an ethnic minority in reeducation camps, due to cultural non-conformance. In one country the current leader's power to change things has been significantly limited, while 90% of the mass media has been downright scornful about him, and the judiciary refusing to do everything he wants, in the other the leader can cancel IPOs, put CEOs in prison for decades for disrespect.

I.e. your level of legal protection is not comparable between these two countries.

So we are indeed in a global competitive job market, but not all presumed competitors are actually competitive.
If you are charging someone 19k USD for a simple cut wound something is seriously rotten in the system. For comparison,in India, one could get this all done for less than 50$ including the medicine, this is without the insurance. People don't even use medical insurance for such trivial things.
Heck, you could get this done for free if you have a Govt hospital nearby.
Perhaps that’s part of the reason she got impeached?

(Speaking of, the masses protesting by government buildings to make that happen showed people that could hardly be paralysed by a concern about what she might say.)
The jit compiler of typical jvms automatically uses the instruction sets (with limits afaik) that are available on the hardware that it is running on.
> any other records should be considered moot, like the suggested TXT record

Yes, apparently I didn't think this through. That leaves the nameserver combo method.

> Given the decentralized nature of DNS it's very simple to set things up before you change the nameservers, and this is widely considered to be the best practice. This also solves the "two accounts trying to claim a domain at the same time".

That only solves the someone trying to snatch your domain after they find out your nameservers have changed. They can still initiate the claim before you do for any other reason.

> I'm just not sold on the idea that it's their responsibility to solve this.

That's an opinion (flawed if you ask me), and has nothing to do with whether proof of ownership is technically possible. And if the pool of combos is large enough and uniquely assigned to each account it's certainly a technical solution to the problem.
I think you are missing a (killer!) feature they rolled out during the beta: the "SHARE THIS" window.

They let you present a window that includes whatever is in your mmhmm video feed. It is the same content as your virtual mmhmm camera, but it comes across as a presentation, in higher resolution so the other participants can read your slides.

It is also very easy to find in apps like Meet when you use the "Present Now" function, because the window title is all-caps "SHARE THIS". :)

(The window doesn't appear on the screen, but it does appear in apps that let you present — I have tried it with Meet and Zoom.)
Show HN: Forexbook – Automated trading journal that syncs with Metatrader
I have read about this.

The hospital charge as much as they can, because some patients are unable to pay. This way they make up the difference (or make more).

The idea is that you go to the billing staff and threaten that you will go bankrupt and will not pay anything. Then negotiations begin. Rich pay cuz they don't care, suckers get conned, and poor gets their credit destroyed. Classic USA.

It is another 'american' system akin to tipping only taken to extreme.
> What else could they do to actively make users run away?

Comic Sans and fellow-kids memes
I disagree.

The border pixel is changing between three non-background colors. I would define that as moving.
Isn't it 1000MB/s now? Anyway, a decent consumer grade 500GiB SSD that will give you ~5GiB/s is in the ~$100 ballpark. If you take an io1 or io2 volume and crank up the IOPS you will get at most 1/5th of that throughput, but burn through this budget in 2 or 3 days. Even with fairly modest IOPS, you would have amortized a much faster physical drive in single digit number of weeks. With io2 at least you get (in theory) better durability (and a few other goodies) than with a normal SSD, but the price and performance differential is still enormous -- I often wonder what fraction of companies with massive cloud spends have anyone in the approval loop who has an inkling of what premiums they are paying over "normal hardware".
FrontPage was a nightmare. I still wake up screaming...

I do see some pretty good stuff, from Wix. The new static generators create great sites, but they are way too technical for most users. Wix and Weebly are -sort of- like that.

I am not a fan of sitebuilders in WordPress. I think they are just reincarnations of FrontPage. I've had to fix a couple of borked sitebuilder sites, and the "fix" was a complete, top-to-bottom rewrite, without the sitebuilder.
PhotoVoltaics are not sustainable.
I do not believe you could - not without significant compromises, since both systems exhibit very different capabilities and security design considerations.

You'd still end up with either a more complex iOS, a severely restricted macOS or a split-brained, dual-booting machine which has trouble even freely sharing files between its boot modes.
The only breakthrough innovation in my book would be cold fusion - it unlocks so many possbilities and enables solutions to problems which are unthinkable right now as they are to polluting the environment or are prohibitively inefficient. It will be a disruptive change like we saw with steam engines taking over, the ICE or electric power transmission.

Second comes self-driving cars. Not because they unlock the potential to stare at your smartphone so that you can give away more of your personal data to the Internet advertisment industry. But it would result in a turmoil in an endless list of supply chains living from the car industry. With self-driving cars, actually owning a car becomes a luxury only a few will be able to afford. The insurance system or fuel supply system will experience dramatic changes. This Schumpeterian destruction will unlock something. I don't know if it will be growth. The past told us that high cultures also quickly disapeared from time to time.
I think diminishing returns will stop 8k from getting mass adoption.

Same thing happened to audio players with "better than CD quality". They never caught on because there was no need.

65" 4K TVs start at 74 Watts (max is 271 Watts). 65" 8K TVs start at 182 Watts and go all the way to 408 Watts. For what? An improvement you won't notice unless you get off the sofa?
https://www.youtube.com/watch?v=l-47Y0-W7v8
I use python-lsp... No that bad. Still have to figure out how to turn off the PEP 8 code style warnings because there are too many of them (I prefer to clean the code style after having working code). It's not as good as PyCharm though, but nice for a start, and rather stable.
What do you mean by “virtual object”, an object which has been broken up on the stack instead of a “real” object living as a single entity on the heap?
The article mentions crash logs. I can sorta relate, my company has their core application built in C (or C++? idk), and they will often have one FTE slave away for weeks analyzing a crash report / core dump, because apparently the code doesn't give nearly enough information to debug a production crash.

whereas in Java you get an exception, a stack pointing neatly at where the issue was and an error that explains what's going on, and you can fix it and move on.

I'd argue that C-like Java is much easier to debug than C.
Tips for Creating Content
It's probably cheaper to study medicine and make your Dr in cuba and do the operation/stitches yourself..plus your a doctor now.
Curious, what’s better?

Also do you have similar levels of job opportunities as NY or SF?
200ms sounds surprisingly high. I can imagine it being hard to press a button two times in a row in <200ms with a cold start, but if you already have a controller in your hand and it's even minimally ergonomic, pressing the same button 5 times with average <200ms delay between each should be relatively easy for most kids and adults.

My guess is, whoever came up with that threshold has never played any console game.
> HTML and CSS are not clean, intuitive, or efficient beyond simple examples.

They do have a steep learning curve. The web is polluted with tutorials and StackOverflow answers from people who haven't learned them yet, like this atrocious thread where most upvoted answers are plain wrong: https://stackoverflow.com/questions/4814398/how-can-i-check-...

> Masters of these tools sadly have their heads full of legacy hacks and trickery needed to get content to display properly.

The trickery is not needed anymore. I started in 1996 and I remember the table and float layouts. You can forget all this stuff now. IE11 supports flex-box well. Clean up your code and move on.

> Contrast this with algorithms, the middle-tier, and databases. These tools, while not perfect, are far better able to express developer intentions and therefore be maintained.

Well, I did understand flex-box after thinking in terms of layouting algorithm instead of a bag of properties and values. [1] But you're dangerously close to comparing apples to oranges here: front-end technologies are all about the user's experience, not the developer's intent. If you feel that strongly about them, consider sticking to the back-end.

> Sadly, the Web stack has largely become popular due to OS politics

No, the web stack has become popular because of the people from your first paragraph: the ones paying the bills. The ones who couldn't afford to lose customers by requiring a plug-in, nor building multiple versions of the same product.

> The concepts of types, intellisense, async/await, and other efficiencies are great examples of historically native benefits brought to the Web.

Types? JavaScript is typed, always was. Ajax was always asynchronous - do you mean the syntactic sugar?

[1] I then wrote that: https://dev.to/galoisgirl/how-to-finally-understand-css-flex...
It's the hospital that wants 18k, not the insurer.
I remember creating my first website using Microsoft Word. That was something.
Maybe "anonymous identifiers" has some very technical and exact meaning that I didn't know, but when I said "anonymous identifiers" I did it very abstractly, no need to assume a specific underlying implementation from those two words.

I have actually discussed the concept in the past [0], and I exchanged some emails with the guy in that thread to talk more about technical details. We all seem to agree that design and political will are the problems, not technology.

What I was basically saying in the comments, in general terms, is that you might have one primary identifier, and then somehow you can get more identifiers that are tied to your main one, but that might have different expiration periods, might grant access to different levels of information about you, and might be limited to a certain number for each service you use. Of course, there are quite a few ways to implement such a system. And that's precisely why I'm more focused on the design, usability and characteristics than the underlying technical implementation; I think the best we can do if we ever want to see this happen is to spread the idea in terms that anyone can understand [1]. I mean, I'm interested in the technical details too, so I'm just complementing and contextualizing a bit here.

[0] https://news.ycombinator.com/item?id=22180120

[1] ...or discuss more the idea among those that are interested and setup a demo website to make it easier to spread the word, even if there's no actual implementation behind it and it's just a mock-up. I'm quite busy at the moment, but I'll definitely do something along those lines when I have some time.
My point stands: Very few people edit 8K video, yet it is a popular benchmark.
Helping people do better remote meetings and presentations more easily seems pretty meaningful in the context of the present pandemic, where millions of people are suddenly having to do that (for the first time, in many cases).
It's capitalism. No one makes you pay. You can do your stitches yourself. Or, try to find a cheaper hospital.

I know it's more complicated than that but everything has its cost. $19k is the cost for the US stitches and anesthesia.

Edit: I'm not a fan of this system but it works. Isn't the US the #1 medical care quality country?
Outrageous billing aside, the problem here is that the insurer can foist expenses on its policyholders rather than pursuing third parties themselves. We'd see abuses like this evaporate if insurers were compelled to do their own recovery. Think a third party is responsible? Ok, sue them.
> Is it headed toward functional parity with the Mac

Since they are never going to give you a real terminal on iPad, if they do reach functional parity, it's going to be by crippling the computers, rather than giving iPads any special new powers.
The company that produced Oxycontin, Purdue, gets to pay a $8.3 billion penalty for pushing addictive opiates, and encouraging doctors to over-prescribe these: https://apnews.com/article/purdue-pharma-opioid-crisis-guilt...
> The Pi can be powered from the same data port so that it only needs one cable.

Great, I didn't know that. I happen to have two pi0+camera that I now know how to recycle :).
Normally yes but that’s mostly a factor of heap fragmentation. It the GC never runs the “old” buffers are always full so you never bother going through them.
trust me, you're not the only one who are still bitter about their idiotic decision.

They had a burning ship. But instead of going into their own newly-built submarine, they trust floats full of money handed out by Microsoft.

F Im furios everytime this topic is mentioned
Facebook fined in South Korea for sharing user data without consent
I still feel a lot of people haven’t read the book About Face, on interaction design. The OP would have been unnecessary.

Different form factors have what they call different postures. It’s a lot less sovereign than a full desktop or laptop. It’s a lot more an auxiliary device, or leisure device. The Ipads sit alongside the spectrum, the pro is more sovereign, the budget ipad is more auxiliary.
One of the big issues when talking about "city size" is the definition of city.

When people outside the US talk about "San Francisco" they mean the 9 county San Francisco Bay Area[1] (pop: nearly 7m), and almost never the City of San Francisco[2] (pop: nearly 900K).

[1] https://en.wikipedia.org/wiki/San_Francisco_Bay_Area

[2] https://en.wikipedia.org/wiki/San_Francisco
Imagine going in to a police station and reporting a robbery. The officer is sitting at cash register and rings up your account and quotes you $8,000 to investigate the crime.

This is how absurd it feels for a British person to see $ values assigned to medical treatments like this.
Im hoping that the "new form factor" rumours for next years MacBook range, is in fact a macPad - the equivalent of a large format iPad with magic keyboard, etc - but running macOS.

It would actually make the new ability to run iOS apps even more practical. Literally open an iOS/iPad app and it behaves exactly as an iPad would. iPads already have keyboards and trackpads, MacBooks have ability to run iOS apps - its not a great leap to see this as the next step.

Id even be happy with a single TB port. Thats all Im using on my 8GB MBP M1 anyway - connecting to a dock for some extra storage, network, power delivery and connecting to 3 4k monitors while in clamshell (and SD card reader, and 4 USB3 ports left over, and daisy chaining...). I really don't get port-anxiety when one gives you all this...

As for making macOS itself touch capable - god no. Keep those behaviours restricted to the views of the "iPad" apps. If you aren't plugged into a keyboard or a dock, or if you enter "iPad mode" (maybe via a hardware switch - like the old silent-mode one), then it could behave just like a regular iPad. Theres none of the windows nonsense if you don't make the "desktop" aspects touch capable.
When we lived in the US my daughter tripped and opened up her chin on the kerb. My wife having no idea what to do (go to Urgent care) went to the ER...

She had 5 stitches and was in and out in about 90 minutes. A plastic surgeon did the stitches and at one point there were 8 folks in the room.

She has no scar and the experience was very good.

We had full insurance, and when the bill came, it was ~$4500 of which we had to pay roughly $990 ourselves.

Still not sure how to feel about it - that's a high price for a few stitches, but if I had a choice of going to a UK hospital for free, or paying a grand to know my daughter will be perfectly cared for, assuming I had that grand, I'd rather pay.

Not everyone has that option though and that's the problem.
I'm not American but go bankrupt will affect your entire life in the US.
That might be possible if healthcare companies were upfront about the cost of their services. But I bet you couldn't find an upfront cost for stitches from 3 hospitals in your area.
>The proposal to delay deletion for 24 hours is content neutral, is it not?

My response to that part was that it's consistent with Section 230 as well as long as it doesn't have to be displayed publicly.

If the requirement is to display it publicly, then I suspect platforms will respond by adding a delay before content is published in the first place, or restricting distribution while leaving the content up (so you'd need to go directly to that page to see it.)
With all these articles I wonder about survivorship bias: where are the ones about people which had a bad experience with psilocybin?
>I'm too European to understand why this makes any sense.

This really reads as "Is this some peasant joke I'm too rich to understand".
Bystanders will be blinded by specular reflections many miles from the battle.
I'm not sure if you're purposefully not understanding my counter-argument, but I'm gonna assume you're arguing in good faith here.

Your original argument was that because "labor, materials, energy and machinery" cost money, there is no use of free knowledge.

My counter-argument is that the one with the knowledge is not necessarily the same person/community that provides the label, materials, energy and/or machinery.

So it's still useful to have free and open knowledge published and consumed, as you never know who can be helped by it, no matter if they have the funds to use it or not. Others might have the funds, and can help by providing material etc.

My argument was never that money is evil and shouldn't exist anywhere, not sure why you went there.

Hope this helps you understand what I meant with my previous comment.
I love how the article basically says "in the end all was solved and the family only had to pay 2 grand".

I am so glad I am an European.
And you are saying that based on which data?
They can claim the domain before you, but like you mentioned used in combination with a matrix of name servers this should quite easily be mitigated. Another solution is to time box new zones.

And don't get me wrong, I think the solution that Amazon and CloudFlare use are better than nothing. Having safe guards against people misconfiguring things are always helpful, and I'm sure it would result in fewer support cases.
Have you thought about trying to find that teacher today and explaining him what actually happened back then with the mushrooms and the essay? Would make for an incredible story
That's usually what happens. The uninsured tend to be poorer, less stably employed, and the hospitals look to extract marginal revenue from these people. Paying for all of the bill collectors, legal review, etc. to get the original bill amount just isn't worth it in most cases, or so I hear from insiders. I suspect in this case because there is insurance that the family will try and succeed somewhat to get partial responsibility from the insurance company. This was emergency medicine for a dependent child - not a commonly excluded category.
Why does a non-profit hospital even remotely need 18k for that though? What is inflating costs so much?
Not sure whether this counts but someone did post their experiences of it on reddit.

https://www.reddit.com/r/rust/comments/bhtuah/production_dep...
Accessing other hardware isn't latency-sensitive, though; that's usually disk and the internal network, for logging, telemetry and control. Typically a trading application will keep a thread running on the shared core and send messages between that and its dedicated core thread using lock-free queues, or simple atomics. As you say, writing for bare metal is a lot of hassle and it's unnecessary for the parts of a trading application that don't need to be super fast; using a commodity OS and isolating resources gives the best of both worlds.