skysight-inc/HackerNews huggingface dataset:
“The thing is, the immune system is very complicated.”

quote from the link here, but for those who don’t want to click through (this article is fascinating though), it is told in the context of a joke which i will post below the link.

https://www.theatlantic.com/health/archive/2020/08/covid-19-...

There’s a joke about immunology, which Jessica Metcalf of Princeton recently told me. An immunologist and a cardiologist are kidnapped. The kidnappers threaten to shoot one of them, but promise to spare whoever has made the greater contribution to humanity. The cardiologist says, “Well, I’ve identified drugs that have saved the lives of millions of people.” Impressed, the kidnappers turn to the immunologist. “What have you done?” they ask. The immunologist says, “The thing is, the immune system is very complicated…” And the cardiologist says, “Just shoot me now.”
Ok, I'll bite. It's in the title of the linked interview, and it's in body text of the interview as MJF actually says it.
Oxford one is also going to be easier to manufacture given that it is based on existing technology.

Many countries e.g. Australia are licensing the formula so this is an important aspect.
4.5 years is "for years" especially in the frontend world
You seem to be arguing for laws that treat people differently based on their immutable characteristics - i.e. gender. I think that's wrong and people should be treated equally. It's true that most of upper management is male - but that fact only incurs a cost on me, not a benefit. The cost is: The upper management is incentivized to promote women (i.e. not me) to balance out their existing maleness.

I could be the "bigger man" by ignoring structural disadvantages against me and people like me, and in real life, of course I do ignore these disadvantages. The reason I ignore them is not because I think it makes me a bigger man, but because if I spoke out against them I would be fired and ostracized. People would hate me for raising or sharing these opinions.

For your point about sexual harassment and rape - this is not something specific to the tech industry and not something that is fixed by deciding to prefer women over men in hiring decisions. Is the idea that, because women are more likely to be sexually harassed or raped, outside of prison, they should get the compensatory prize of these career benefits I've described? That just seems like a non-sequitur to me.
I have very little to do with MacPorts's ARM support, I'm not even a maintainer ;) Most of that infrastructure was already there from the PowerPC→Intel transition, and Apple engineers had patches for basic support ready fairly quickly. I worked a little bit on early support for some heavily-depended-on packages, but I wasn't really directly involved in the effort.
Typescript compiles to js. Presumably you could have a typescript layer for this - but at that point it seems like your time would be better spent translating typescript to a compiled language than going ts -> js -> interpreter
There was one vaccinated but then severe case in Pfizer trial out of 170 cases evaluated where placebo-then-ill cases are included, or 1 from total 8 vaccinated but then ill.

“There were 10 severe cases of COVID-19 observed in the trial, with nine of the cases occurring in the placebo group and one in the BNT162b2 vaccinated group.” (1) “170 confirmed cases of COVID-19 were evaluated, with 162 observed in the placebo group versus 8 in the vaccine group.”

1) https://www.pfizer.com/news/press-release/press-release-deta...
Eh, I think speed to manufacture/distribute is more important. The cost of these is trivial compared to social distancing/lockdown.
> There were no hospitalisations or severe for both the Pfizer and Moderna trials that was related to the vaccine.

I think the commenter wanted to know whether anyone who received the vaccine was hospitalized for anything covid related, not for anything vaccine related.
Incoming possible Silly, Stupid and Lazy Questions,

1. Are there any vaccine ( of any Disease ) that are 100% effective? Or do we operate ( as I would assume ) something like 5 Nines effective rate and call it 100%?

2. Across all type of Vaccine, what are the average or median effective rate? i.e Should we expect Vaccine to be 90%+ effective in the first place? Or is that a wrong expectation to make?

3. What happens in the case of 10% ineffective, do they take a third dose?
Comfortable, fast, safe, travel is expensive. Just traveling itself is relatively cheap, you just need a backpack and shoes.
Why is the work place the appropriate venue for non-industry politics?

Lobby groups, human rights associations, charities and polticial groups would gladly take your ICE funded profits and work for your goals.

The requirement for bosses and employees to be personally calling political shots in their personal and professional lives makes me think the corporations would prefer to be divided so they can make the call on their own terms.

We know ICE can get SAAS services elsewhere so what consequence is really being prosecuted here?
> We don't need to eradicate it, just get things under control

Based on what we've seen there is no grey area. Either you fully control it which then ends up basically eradicating it e.g. Australia/NZ or you don't and then you end up like EU/US and going in and out of infection waves.
List of tools/apps that impact your life (Tools bio) – Startup idea
A dispute as to whether or not a person signed a contract will be difficult to resolve regardless of whether the document was signed on paper or glass.

I don't think this is the problem that these services solve.

Their purpose is to replicate the ritual of signing a document, to draw on the meaning of that tradition, so that that reasonable parties to an agreement understand there is a clear threshold that signifies the transition from negotiation to agreement, and all parties have a common version of the details of that agreement.
So, the Oxford vaccine stated "... no hospitalised or severe cases ..."

The Pfizer press release states:
"There were 10 severe cases of COVID-19 observed in the trial, with nine of the cases occurring in the placebo group and one in the BNT162b2 vaccinated group."

So, zero severe cases for Oxford, and one for Pfizer.
Interesting.

Should also point out the Pfizer trial may have had 43,000 participants, and the Oxford one 24,000, so they are different size trials.
Also, it's super easy to miss important details when comparing outcomes like
this, to do this properly really requires a project or in-depth investigation,
not my 15-minutes research effort. :)

Pfizer release:
https://www.pfizer.com/news/press-release/press-release-deta...
Restic is great indeed. Takes some time to get started, I appreciate that encryption comes first.
If everyone went into software engineering, we would all starve to death. There are very few things that society could survive “everyone” doing - a diversity and balance of complementary behaviors are important.
Yes, they do state that all of the results are statistically significant though, with very low p-values.
IANAD but my guess is maybe a stronger immune response in the first dose makes the immune system respond so quickly to the second dose, that it doesn't have time to get anywhere and interact with enough of the body to have much of an effect. That way a weaker immunization in the first dose leaves more room for the second dose to have a refreshing/strengthening effect. Basically, 1 + 2 > 2 + 0
>> Is it legal to have a camera on your house pointing at the street? And is it legal for you to live-stream it?

What if it offers a view of the house across the street? Or into their window?

Also, it's one thing to have a camera record 24/7 so footage can be reviewed later. It's very different to add motion detection and face recognition to ubiquitous live streams that include views of other peoples property.
Because perfectly good alternatives don’t exist? i.e. glass is far more expensive to produce and ship, it’s heavy and brittle etc.

Glasses are great, and have some wonderful properties, but so do the the various plastics–they’re responsible for raising living standards for millions of people.
Worth mentioning that the first quote is directly from Vonnegut in an interview, whereas the second is spoken by a character in one of Heinlein's novels.
I'm pretty sure that your credit card company sells your transaction history to other companies and also shares it with the Government.
>[..]Then google bought it.[..]

And that will happen to every competitor on that market.
> 2. Across all type of Vaccine, what are the average or median effective rate? i.e Should we expect Vaccine to be 90%+ effective in the first place? Or is that a wrong expectation to make?

Sometimes, vaccines are only 30% or 40% effective, leading to terrible flu seasons.

I don't really know the mean/median/mode, but 90% is really high for a vaccine.

> 3. What happens in the case of 10% ineffective, do they take a third dose?

How do you know if someone is one of those 10%?
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My understanding from the Pfizer press release, and I quoted it, is that there was one severe case in the vaccinated group. Did I miss something?
What are the storage requirements for the other two?
My family has owned Lexus cars and dealt with dealers along the east coast for 30+ years. Maybe we've been lucky all along, but every one of them have provided similar experiences like the one described in the OP. Purely anecdotal but maybe there's a trend in Lexus to have great customer service at dealerships. I wouldn't be surprised to discover that there is a crappy Lexus dealer, but my experience in Pennsylvania, Massachusetts, and Florida indicates otherwise.
Check out http://essaypapers.reviews/
> you need around 70% immunity in the population

This is the required immunity of the population, but not the effectiveness of the vaccine. Inside the population there are groups that you cannot put the vaccine (smallest babies, immunosuppressed people, etc).
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There are a lot of different video games suppliers online, which ones are real, which ones are fake? I just do not know, anyway, I want to purchase PoE Currency online, how about Eznpc, is it safe, legit? Can I just place my orders over there?
The silent majority is pretty fucking stupid as a whole. It’s hard to have an informed populous when they are allowed to censor the stories that make their emotions feel bad. It’s like allowing grade schoolers to vote on what they eat for lunch every day.

As a reddit user, this is what you’re dealing with. The non-college educated majority has control over the following things:

- what politics you see
- what comments you see
- what science you see
- what news you see

It’s going to take a while, but one of the emerging lessons of this era is that democracy for information spreading is a pretty terrible idea. Ted the conspiracy enthusiast/barista maybe shouldn’t have the same voting power on a comment thread about orbital dynamics as an astrophysicist.
I'm not suggesting the bird will think in terms of an exchange rate, I'm suggesting they may experiment with random behaviors (like tearing things in half) and it's important that none of those behaviors are re-inforced by leading to more food output. And I do not think it's at all unreasonable to suspect that the bird learns that putting a piece of trash in a slot yields 1 foot pellet, so if they tear the trash in two they can get 2 pellets.

A crow at the beginning of this talk figured out how to bend a metal wire to use as a tool when a straight wire wouldn't work.

https://www.youtube.com/watch?v=0fiAoqwsc9g&t=17s

And the crow in this video figures out how to drink water at the bottom of a bottle by displacing it with pebbles.

https://www.youtube.com/watch?v=xVSr22kqSOs
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-80C for Pfizer, and below 0 for the other one (I forget exactly).

-80C is really close to dry-ice temperatures. So I wonder if its actually -80C or if the researchers were just saying "Dry Ice".
It's a small miracle that Ozzy Osbourne is still alive at the age of 71 at all, considering his decades of alcohol and drug abuse were wild and excessive even by "sex, drugs, and rock 'n roll" standards. He maxed out on constitution during character creation.
Title is misleading. They tested few configurations, we should use the most optimal one, not the average. Much better source:
https://www.astrazeneca.com/media-centre/press-releases/2020...

Good:

+ likely 90% effective if we use optimal dosing

+ no significant side effective. Looks better than Pfizer or Moderna.

+ already pre-produced at huge scale, 3 Bln doses in 2021

+ easy to store and administer, just regular fridge required

+ several times cheaper than mRNA

+ more traditional vaccine than novel mRNA, less tail risk in production and scaling up the process

Not good:

- two doses, efficient one month after first injection

- likely public will be confused about efficiency due to dosing regime
Duplicated with this one in the top?
https://news.ycombinator.com/item?id=25184331
-20c and -70c from what I remember
Here's a list of Lexus models with pictures, and starting new prices: https://www.caranddriver.com/lexus
I guess they probably intended to link this: https://www.hodinkee.com/articles/buzz-aldrin-rocking-three-...
This is an old but informative video on UNIX system productivity by AT&T hosted by Brian Kernighan [1].

Fun fact, the original unused PDP-7 computer mentioned in the article that being utilized by Ken Thompson to first develop UNIX actually belongs to another well-funded sound processing research group in Bell Labs.

[1]https://youtu.be/tc4ROCJYbm0
Even for people paying attention, it's hard to follow all the spin and understand which organizations are pushing which ideas and why.

The US now has tens of millions of citizens that believe the election was stolen. I think they're mostly just "normal" people who have tuned out and now can't tell which way is up.

The reason I pay attention is because following news daily is actually less cognitive load than trying to catch up when a significant plot twist happens that might impact me.
I tried making it a plain function at one point but ran into some weirdness around using void * * with certain arguments (const buffers?). You don't want to accept plain void * because it's too easy to pass a pointer instead of a pointer to a pointer. Using a macro is (ironically) more type safe.

Maybe someone else could figure out how to do it properly, since I'd definitely prefer a function.
There's no doubt that variance exists among franchises. But how much leverage do manufacturers have over their dealer networks?

I imagine if Toyota is going around building their Lexus brand around "concierge" level service, they could attach bonuses to this metric—maybe weight the bonus more heavily in that direction than they do for their Toyota brand—and punish dealerships that disappoint their customers.

Then again, a lot of dealerships are owned by huge dealer groups now, so the power balance isn't always tilted toward the manufacturer.
All those were used for tiny of functionality in browsers and did not even remotely approach the performance and functionality of the real desktop applications.
The two existing mRNA vaccines touted earlier also require two doses.
1. Smallpox vaccine is 100% effective
2. 90% is high.
3. Probably not. Immune systems are weird and incredibly complicated (think even more complicated than the brain).
This is how OpenJDK optimizes out some null checks as well.
How do we know there aren't long term side effects?
>How do you know if someone is one of those 10%?

I would assume everyone have the vaccine and they still get caught COVID afterwards?

Or do I misunderstood what effective means?
-80ºC for Pfizer vaccine and -20ºC for mRNA vaccine.
https://www.npr.org/sections/health-shots/2020/11/17/9355633...
It adds absolutely nothing and cheapens a potentially valuable message.

People don't take you as seriously if your emotional palette is so scarce that you can't form a phrase without dropping a "frigging" in it.
Another huge differentiator is price. At $3 to $4, many countries will jump on board ASAP and stay away from the expensive vaccines from Pfizer and Moderna.
Seems like the sample size is probably too small to draw any conclusions there. 131 got covid in the trial, if 70% effective than 39 should be from the group that got the vaccine (i think. Did i do that right given they're combining the two dosing regime)?

Maybe its chance that none of those 39 got really sick. I'm not sure what the age breakdown of trial participants was- were the people in the oxford trial younger? Did the distribution match the distribution from the mRNA trials? I have no idea.
Dealership model will end up killing all conventional car manufacturers it’s like a giant lead sinker
the mRNA style viruses will probably decrease in cost exponentially the same way that DNA sequencing and computer technology have dropped in price.
Whats wrong with javascriptcore?
My grandmother had severe arthritis and her fingers lacked the fine control needed to set her watch. So she simply kept it set to the same time zone all year round and made a mental note to subtract one hour for half the year.
Apple's linker will automatically adhoc sign binaries on AS systems so it shouldn't require any work for most people.

Anything run from the Xcode UI (or Terminal if you use "spctl developer-mode enable-terminal" to show the Developer Tools group under Security > Privacy in System Preferences) and enable Terminal is exempt from GateKeeper notarization checks. You can also put other terminal clients in the same list and they get the same benefit (child processes exempt from GateKeeper).

In a similar note "DevToolsSecurity -enable" allows any admin or member of the _developer group to use the debugger or performance tools without authing first. (Normally you must auth the first time and the authorization can expire if you don't unlock your system after a certain amount of time).
A Game Designer's Analysis of QAnon
"The Devil's Chessboard" and "The Mighty Wurlitzer" are the two books I'm most familiar with on this topic, but I'd be curious to hear any specific recommendations you have as well.
My comment was directed at Fox, even though of course he'll never read it.

(Yeah yeah, I know, "old man curses at television set", etc.)
Not an epidemiologist, but I think the goal of mass vaccination if to make R drop to well below 1. If everybody is vaccinated with a 90% effective vaccine, then R drops by a factor of 10 (I think) so that sounds pretty good?
From what I see you are a braindamaged lockdowncel.
Is that the same vaccine that was approved in Russia? I remember Russia was working with AstraZeneca on their vaccine, but not sure if it's the same one.
If they already got Covid then a third dose of vaccine is pointless.
But that’s lame even for a conspiracy. Step 1 if it was a conspiracy would have been certainly to go after the funders because they were loose ends.
It gives me the same eerie feeling as listening to number stations.
yup. pulumi has much more same syntax and management.

however, some parts still use terraform underneath. if stuff doesnt work - i sometimes find myself on terraform docs/code.

but all in all a good trade off for me compared to pure terraform.
I can see how it's limited on an embedded device.

But C has way more "wat" in it than JS, in a sense. In JS when you make a wat you can generally debug it and fix it incredibly easily. In C when you wat, well, good luck.

A linter and Typescript and the fact that the "wat" stuff is actually almost always marginal and not commonly ran into in practice means you actually almost never are spending time on wat-ness at all in TS, where in C, a huge amount of time is spent there.

There's a vast gulf of productivity between TS and C (the former winning). TS is an incredibly smart choice for many things small and large. But yes, if you need a lot of low level hooks and incredible performance, don't use it.
> Everyone hates the feeling of having wasted their time doing nothing.

My 2020 in one sentence.
Interesting its cheaper than mRNA, i thought that was one of the benefits of using mRNA, was that it was supposed to be cheaper to manufacture.
Not really. We haven't (yet?) eradicated the cold or the flu, but we manage to live with them. We need to be able to protect the most vulnerable (probably something like 30% of the population) and reduce load on the healthcare system.

Right now if every activity would be fully available (concerts, conferences, airlines, etc.) every healthcare system across the world would probably be overwhelmed within 2 months, max.

Once we reduce the rates to a trickle, things are probably good enough.

I'm not saying that we shouldn't try to eradicate it, but as with everything, unfortunately, things are frequently taken to a point where they're "good enough" and no further.
I haven't seen your work, but this to me is generally excellent advice. I wish more people would provide and hear it.

There is a level of effort required to get good at effectively conveying information to others, and it is best learned by critically observing the situations that have done so in your personal experience.
I wonder what happens if you get two doses, but not of the same vaccine?
Wasn’t aware that the Ring cameras were on the web.
It's definitely true that there aren't enough houses being built to keep up with the way people want to live, and that the houses that are built are the wrong sort of houses. I'm in the process of buying my first at the moment and it's immensely difficult to find something suitable and affordable (UK dev wages outside of London don't compare well with the US...). I'm not sure if that's entirely down to homeowners though, or construction companies only building massively profitable mansions instead of small first-time buyer size homes. There definitely isn't much to choose from where I live unless you have 2 good incomes to spend on it.
Isn't it more common to determine the dosing regime in Phase I/II trials, and use the Phase III trial as the final test for efficacy?
It's not black and white. You don't have to turn off all news to avoid the junk. There are still people who serve meaningful news; you just have to know where to look.

People mean very different things when they say news, I've found. Most of what people think of as "news" is human interest story garbage churned out as quickly as possible to get the most number of eyeballs. This category includes even a lot of supposedly reputable newspapers, unfortunately. This is great if you are looking for lunchtime gossip or just something to distract or entertain yourself with. Not so good if you want to learn something or expand your world view.

The way I see it, good news

- gives historical context,

- dives deeply,

- covers the entire globe,

- discusses incremental changes and not only big events,

- reflects on multiple perspectives,

- doesn't overemphasise human interest stories, and

- provides you with actual data.

Good news, ironically, ages well.

There are still some people that work with real news. There was a recent Ask HN about favourite magazines and journals[1], where some of the comments mentioned The Economist[2] (a long-time favourite of mine) and Delayed Gratification[3] (which I can't personally vouch for but I admire their goal.)

[1]: https://news.ycombinator.com/item?id=25159931

[2]: https://www.economist.com/

[3]: https://www.slow-journalism.com/
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Maybe for less developed countries, but i think for major economies, the price difference is insignificant relative to the benefits of any vaccine.
It is! And I had the same conclusion when it came to highlight the active section… it's not worth repeating the markup. Maybe something with `:focus-within` could work?
Another article I read seemed to indicate they haven’t investigated the half dose regimen fully so it sounds like until more testing is done that’s not the recommended path (in which case the headline is being generous).
Online visual prototyping of Angular apps with JitBlox