skysight-inc/HackerNews huggingface dataset:
I can't speak to the clinical aspect of medical imaging but I've done some development with medical images. If you end up pursuing your diff concept here are a few things which might help point you in the right area or give you some additional keywords when searching:

1. CT images measure densities of tissue (in Hounsfield units).

2. The images will first need to be aligned/registered/fused. There are different ways to do this but it can be difficult if the two scans were done with different protocols/hardware as the image resolutions and dimensions can differ but also anatomy regularly changes (not as much in the head area).

3. Fusions are often described as having a primary (unchanged) and a secondary (the image that's modified to align to the primary).

4. Fusions can be very basic rigid alignments (like moving one photo on top of another) or be fancy by moving voxels independently (often called deformable registration, like cutting a photo into squares and moving them) however these are difficult to evaluate for correctness.

5. Fusions are often viewed as a transparency overlay of one image on top of another (in the case of deformable it's the deformed image over top the primary).

6. After doing a fusion a subtraction can be performed to find the difference in image values (the densities).

Best of luck and enjoy the field.
What are the best websites to ask free legal advice?
So, if the old key is public, we can't use DKIM to verify any leaked emails that were acquired after the publication date?

Sounds suspiciously like somebody's thinking ahead on how to plausibly deny some yet-to-be-leaked emails.
You don’t have to assume everyone is out to get everyone, just that someone might possibly be out to get someone.

Also, whatever you assume, there are legal and moral obligations to protect information in any case.
Yes, it’s worth it in that you get more, highly engaged readers of your content with email signups. Some of them are web readers who read more because the reminders prompt them, but many are email readers who don’t really want to visit your website but want your content. It makes a lot of sense to offer a free subscription to someone instead of making them search for it.

There are also readers like you and me who look everywhere on a site to find what we want. They don’t need a pop-up and may resent it.

Of course you need to do the additional work of sending good email. That’s part of the appeal, that you’ve done additional work for the reader and are inviting them to enjoy more.

Why so much of our economy and society is driven by people asking other people to do things for them is a good question but above this particular consultant’s pay grade. ;)
The CDC updated their pandemic planning scenarios[0] based on earlier studies in Europe plus some educated guesswork using data collected from the US through August 8. The numbers which you represent as the CDC’s sole official estimate of true IFR are only one of three possible sets of parameters that they provide for scenario modelling. Furthermore, the footnote on these estimates states “The estimates for persons ≥70 years old presented here do not include persons ≥80 years old”, since the underlying study they base the model on assumed that CFR = IFR for people ≥80 years old. Why they label this 70+ instead of 70–79 is beyond me, and I have no idea how sound the methodology is that they used to derive these estimates.

I would also mention that there are studies in peer review on patient populations in the United States which suggest IFRs closer to CDC planning scenario 4/5 than 3—for example, this one from Connecticut[1]:

18-29 0.01 (0.01–NE)
30-44 0.11 (0.06–1.74)
45-54 0.18 (0.11–0.63)
55-64 1.30 (0.68–16.94)
≥65 16.46 (6.58–NE)

We all hope for the best—that the lower bounds are true—but I think we should also be prepared for the reality that the upper bounds might be the correct ones, and act conservatively.

Also, you know, all IFR estimates assume that patients will actually be able to access care. Without hospitals, IFR approaches IHR, and the hospitalisation rates from the Connecticut study are grim: 0.8%, 2.68%, 3.09%, 12.43%, and 79.89%.

[0] https://www.cdc.gov/coronavirus/2019-ncov/hcp/planning-scena...

[1] https://www.medrxiv.org/content/10.1101/2020.10.30.20223461v...
Doesn’t mean you can’t try. Being deliberate with whom you associate is all you can really do.
The caveat is that “dczot” doesn’t know what a caveat is.
The CheapStack: How I host my website for free
My wife took her maiden name as her new middle name and my last name after we married. Different databases and documents have her with her old middle name, new middle name, or her middle initial (unchanged).

I always have to verify which document she'll be showing at the airport when buying airline tickets (in the before times, anyway).
I guess asking one person rather than 200 is one way of getting less communication noise.
Love the idea. Would be interesting on the mobile.
The steelman version of antivaxxism isn't "vaccines shouldn't exist", it's "on an individual basis, the risk-reward ratio of certain vaccines is not worth it. I should personally not vaccinate myself or anyone I care about, and be a free rider on societal herd immunity"

That particular version of antivaxxism is the one I would have the most trouble refuting. It's especially troubling since if it were true then the powers that be would have every incentive to try to keep it quiet and attack anyone who suggests it.

I mean, I make the same judgement call every year for flu shots. Is it at least plausible that I would be better off overall making the same call for some other disease?
Many ETFs (SPY being the biggest example), funds, other indices, etc. etc. etc. have legal fiduciary obligations to track the S&P 500 index. SPX is market cap weighted, bigger companies get a bigger piece of the pie than smaller ones.

TSLA will be entering near the top.

Just SPY has ~$320 billion under management. If the rebalance were to happen today (to my best quick calculation), TSLA would make up 1.2% of the S&P 500 index.

Just the SPY fund would have to buy just under $4 billion dollars of TSLA stock (more than 1% of the total shares) and sell an equal amount of the rest of their portfolio.

Many many other funds would have to do the same.

We're talking about tens of billions of dollars of stock sell orders.

>Why would they sell stock? You can buy shares with cash and you can source cash many ways.

The various funds are obligated to allocate their managed assets to match the index weighting. We're not talking about a small fund, but a significant portion of the entire market reallocating assets.
> the biggest problem with Healthcare.gov was not timeline or budget. The biggest problem was that the site did not work ..

If my memory serves me, a bunch of editable PDFs and drop-down selection boxes that gave no clue as to the correct content. Some serial number, depending on your insurance provider, AS234 BD568 and so on. A total mess.

https://web.archive.org/web/20140122141413/http://www.shirky...
Speech has consequences. Given the good done in holding rogue "politicians" accountable, not seeing that as axiomatically desirable is at least a little bit suspicious...
U.S. nuclear industry group sees reprocessing as potential nuclear waste fix
Show HN: I created a script to change your Twitter banner every day
A communist propaganda platform where free speech is no a thing and loved by US teens.
I understand what you’re saying but your $10-25k example cripples your point. Many people are hosting for extra cash, so any surety bond would keep away a lot of hosts that are actually honest and good hosts.
Perhaps so. It would be interesting to know how you would frame a law that defined ‘legitimate need’ doe data?
Not being able to respond to scripts you're aware of quickly and concisely shouldn't be a point of pride. The game isn't to detect a conservative, it's to discover a strategy that does the least harm and to convince others of its merit.
There is a great comedy routine about identity theft. It's by Mitchell and Webb. Here is the link: https://www.youtube.com/watch?v=CS9ptA3Ya9E

Don't keep reading if you don't want a spoiler.

.

.

.

.

The gist of it is that the customer says "this sounds like a bank robbery, not identity theft. I have my identity, but you don't have the money, so it sounds like they stole your money, not my identity".
Yelp can easily expose businesses to people who are more likely to give bad reviews too.

I mean they collect this data on every profile - some reviewers have a TON of 1 star reviews. Hide the restaurants that pay and increase exposure of those that don’t to these reviewers to get them to give poor ratings.

Obviously there is no way to prove this, but it would be a great way to get people to pay while still maintaining plausible deniability. After all, the one star reviewers still have to go to the establishment and have their bad experience.
> But you still assume that the employee isn't smart enough to know why bolts are different sizes and whether a bigger bolt could work in the place of the smaller bolts.

It sounds like you are not familiar with this disaster:

https://en.wikipedia.org/wiki/Hyatt_Regency_walkway_collapse

There may be a very good reason things are the way they are.
There are 2 kinds of subreddit: novices and oldhats. Oldhats hate being hawked to, but novices really enjoy any info. Ask oldhats what they use and why, what are the pain-points. For novices, offer free info that gently points towards your product. Redditors in general have an aversion to paying for stuff so use it more for knowledge and generating positive buzz by sharing valuable information.
This seems incredibly dangerous as visitors on a tourist visa are required to register themselves with the local police within 24 hours of arriving at their destination.

Trying to stay under the radar seems like it courts risk of deportation, as I've known _lots_ of folks who got a visit from police at their place of stay who were not aware of this. Virtually all of them settled things fine but it was more headache than had they just done what they're supposed to.

I believe in a hotel stay, your hotel registers you online so that you don't have to deal with this.
Wow! Until I read the last sentence, I was going to suggest using a walking stick as a visual way of signalling to others that you have some sort of disability and can’t just quickly move out of their way. As a (mostly) healthy and regular pedestrian, I come across the groups you mention – and those who walk with their eyes glued to their phone, expecting others to move out of their way. I really would’ve thought that they’d show more consideration to older people or others, such as your uncle, who are obviously less sprightly. :(

I love going for walks and every now and again, I have to remind myself that I’m lucky to be able to do so and shouldn’t take it for granted. Best wishes to you and others who don’t have the same luxury.
I feel the same way, anyone who does not believe in the 10x engineer has just never met one. Sometimes the software they produce is absolutely stunning.
Familiarity and Belonging
New WebKit Features in Safari 14
It's the second largest economy. And I agree that it's practically impossible to avoid it completely, I only suggest avoiding it where possible.

My personal rule is to not buy anything made in China for more than $100. I can't avoid buying Chinese for cheap plastic crap, but for significant purchases it's worth the time to be ethical in your purchasing decisions.
> Do you really want someone in 2031 to be able to contrive fake signatures for the emails of politicians in 2021?

How could it be used for that purpose then if it’s proven to be unreliable?

It would seem that there’s more to gain in the short-term by those that have hacked Gmail accounts by exposing this, so it seems disingenuous, which you have to know, so it seems like people are fake-goading Google, causing others to actually goad Google, maybe to try to expose those that have hacked Gmail...

Pretty sneaky sis!
"If you find a project where only one person know what is going on, chances are that person is not good at writing code for humans, not that is a coding god."

This is hard for many to grasp, but if you get the opportunity to lead enough teams it will become clear. And it makes sense, if you think about it. An individual who ended up owning a particular piece of a codebase will be incentivized to obfuscate and obscure their code in order to maintain full control over it. It's job security and furthermore if it's a valuable piece of the product then it can keep praise and rewards centered on you. We should also not be quick to blame the individual for perpetuating this, the right incentives need to be in place to reward both team progress and individual progress.
This is the short version of the SPY prospectus:

>The investment seeks to provide investment results that, before expenses, correspond generally to the price and yield performance of the S&P 500® Index. The Trust seeks to achieve its investment objective by holding a portfolio of the common stocks that are included in the index (the “Portfolio”), with the weight of each stock in the Portfolio substantially corresponding to the weight of such stock in the index.

Commodity and leveraged ETFs play games with futures and options to achieve goals, I'm not aware of any significant index focused ETFs that don't achieve their tracking goals without mostly holding common stock.

Even if they're holding derivatives instead, it's just a layer of indirection and has substantially the same effect as portfolio rebalancing.
Several video game consoles from back in the day (the Magnavox Odyssey 2 and Entex Adventurevision) used the MCS-48 microcontroller mentioned in this write up instead of more conventional CPUs of the time like the 6502 or Z80, which seems a bit strange.

Having dabbled in both MCS-48 and 6502 assembly I can tell you it was probably not done to make software development easier. :) I suspect maybe the hardware was just easier to design around a microcontroller? ...but there could have been other reasons...
"A key point about Sweden is it appears they had a lot of people behaving responsibly despite not using the force of law."

Mandated lockdowns are precisely for the people who don't voluntarily behave responsibly. And damn Sweden has a lot of them too.

Worse, those in charge used their authority to mandate NOT using masks:
https://www.sciencemag.org/news/2020/10/it-s-been-so-so-surr...

https://time.com/5899432/sweden-coronovirus-disaster/

Swedes failed each other, and the failure to employ legal authority effectively meant their government did too. And their economy is no better for it https://www.nytimes.com/2020/07/07/business/sweden-economy-c...
From the non-encrypted ICloud, the eavesdropping on Siri conversations, to the non-encrypted spying about opened apps going through 3rd party server and some zillion other cases of Apple screwing up privacy... I'm not sure Apple cares about privacy beside their marketing propaganda.

Why do we need to take side ? big tech are like choosing between the plague and cholera.

The message to spread is not "Apple/Google is better for privacy", it's " Google & Apple are both screwing up our privacy and have awful anticompetitive practices, so buy an Android or IPhone whatever cause we don't have choices right now, but if you want things to change support Purism/PinePhone/Protonmail/EFF/FSF/etc."

We need people to realize the harm both Apple & Google ( & Amazon & etc.) are doing to our privacy and society rather than having them thinking one is the bad guy and not the other.
It's not just direct metabolism of stuff in the diet. Your body indirectly makes stuff that is then metabolized into uric acid (e.g. your DNA). Could be making too much, could not be excreting enough.

"Many factors contribute to hyperuricemia, including genetics, insulin resistance, iron overload, hypertension, hypothyroidism, chronic kidney disease, obesity, diet, use of diuretics (e.g. thiazides, loop diuretics), and excessive consumption of alcoholic beverages. Of these, alcohol consumption is the most important."

"Causes of hyperuricemia can be classified into three functional types: increased production of uric acid, decreased excretion of uric acid, and mixed type. Causes of increased production include high levels of purine in the diet and increased purine metabolism. Causes of decreased excretion include kidney disease, certain drugs, and competition for excretion between uric acid and other molecules. Mixed causes include high levels of alcohol and/or fructose in the diet, and starvation."

https://en.wikipedia.org/wiki/Hyperuricemia#Increased_produc...

Purines and pyrimidines make up the two groups of nitrogenous bases, including the two groups of nucleotide bases. Two of the four deoxyribonucleotides (deoxyadenosine and deoxyguanosine) and two of the four ribonucleotides (adenosine, or AMP, and guanosine, or GMP), the respective building blocks of DNA and RNA, are purines.

https://en.wikipedia.org/wiki/Purine

Could just be a bad roll of the genetic dice with a dash of lifestyle.
It's unlikely that voters would be ok with all-around corruption of the police, but not unlikely at all that they'd be ok with, for example, harassment or overuse of force against minorities. Historically the Jim Crow south is a direct product of local policies, so I think the historical record supports this view in fact.

While state and federal government aren't devoid of corruption either, at least more homogeneity can be achieved at these levels. Local jurisdictions are more prone to extreme population disparities just by virtue of being smaller.
It could be buying out whatever package is being left behind at a previous gig.
I didn't downvote, but I can see why.

It seems like you didn't read the FT graph. It's showing the total death rates in a graph, and during initial spike in COVID, Sweden showed 20% increase during the peak. By definition, there's no "skewing" possible, since it's all death - unless you're claiming hospitals are making up death.

If your main point is that reported death due to COVID might be inflated, sure, that's possible but that doesn't mean there's no increase due to COVID related death. If you want to point out the reported number due to COVID might be slightly higher than it really is, you should at least acknowledge that there is meaningful and substantial increase in death due to COVID as there absolutely is. By omitting that, your post can't be distinguished from someone posting with a conspiracy mindset and ignoring actual data on substantial increase in death.
What Tulsa and others are doing to woo remote workers away from Silicon Valley
This was one of the most surprising parts about Nomad for me.

I really want to like it, and for the most part I think it's a great experience, but if you're looking for a lightweight single-host PaaS-type thing, the minimum recommendation and default configuration for 3 servers is a bit wild.

I have Nomad running in single host mode on a DO box for personal stuff, and I get the distinct feeling I'm not really meant to be doing it.

3 instances minimum is a big ask IMO
> If you insist that the difference between "lockdown" and "no lockdown" is whether the authorities back their restrictions with legal authority, it makes the term "lockdown" meaningless and you should stop talking about it.

You've explained a pretty clear and meaningful distinction. You may not think it is important, but it has a meaning. I'm saying this as someone who supports authorities backing their restrictions with legal authority and vigorous enforcement.
This is exactly my point, and yet my comment gets downvoted.

People seem content with vaccines, meanwhile I want to understand WHY some people fair better than others. There's a far better solution than vaccines to be found, if people are willing to ask the question, and look for it.
Because once upon a time you could trust and at the same time people didn't feel like that they had that much to hide. In modern society secrecy is the only new 'experience'.
Presumably they multiplied the probability of this occurring with the damage caused and decided that it was lower than the benefit of the high-trust society.
full report
https://data.consumerreports.org/wp-content/uploads/2020/11/...
Not really. Institute policy disallowed curve grading. I also found the better students to be generous in helping me understand the stuff. Without them I would have flunked out.
Ask HN: Ballparking the valuation of a startup based on raised amount?
Is there a rule of thumb for estimating, as a third party, the current valuation of a startup based on knowing the round of funding they're up to and the amount of money raised to date?

Obviously this would vary a lot between different companies, but I don't have any intuition about this at all. I'm supposing that there's some upper/lower limits that you can use to estimate. For a startup that is traveling well I'm guessing that the lower limit is the amount they've raised so far and the upper limit is somewhere on the order of 10x-20x the amount they've raised so far. But that is a total guess - does anyone have any better intuition than me?

As an example, without knowing anything else about the company, what sort of ballpark would you guess for a series B company that has raised $50 million so far? Would $100 mil - $500 mil be typical?
How very sad.
And apparently you a not familiar with what a cargo cult is?
Let's see your mail spool. After all, how else can we know you're not having illicit conversations with politicians that we all deserve to know about?
If we want to be the biggest pedants we possibly can: you're confusing "less games" with "fewer games".
Incredible! What an environment that must be! I hope my kids will find themselves in a university like that.
I don't think the story ends here.

If the tests are the issue, they can just send another DMCA specific to those pages.

Either way, I think in the US anyone who has the most time and money wins, so… good luck with SLAPP.
I don’t understand - don’t they have legal obligations to protect? Saying ‘but we trusted’ won’t work in a court.
Think about the people who are old, immune compromised, sensitive to something in the vaccine, etc.: vaccines protect them when enough people in the community are vaccinated that the virus cannot spread. You personally may not be at high risk but it’s still non-zero and your decision to get vaccinated will help people who for whatever reason cannot.
New Type of Test May Better Discern Immunity to the Coronavirus
Police are totally unaccountable. Chicago police receives over 40% of the city's budget. The police profit off of crime in the city. As crime rises there are often calls to fund the police more to combat it rather than invest in the communities where crime is the highest.
Watching non-work related videos at work doesn't look good.
> An individual who ended up owning a particular piece of a codebase will be incentivized to obfuscate and obscure their code in order to maintain full control over it.

That's fair, but I've also seen an orthogonal effect happen maybe more often where an engineer structures code just naturally in a way that fits them well, but is poorly understood by others. Not due to the incentives of maintaining control or job security. But simply because the engineer wasn't talented at making good code for other humans, and there were very few incentives to write code good for other people, at least early on in the design.