skysight-inc/HackerNews huggingface dataset:
Before I get to comments on the meta information of this article - I'll just point out that the article is complete hyperbole, CRISPR is being used in the clinic, thats not the only metric by which to declare "crispr is dead" anyway, and that the article makes some fundamental errors in the use cases for CRISPR (the 1% number cited used to be accurate for one subtype of crispr editing, has been superceded, and is not the type of edit that has its main clinical use today anyway). Theres a fundamental misunderstanding of the value of CRISPR that would take another article to correct.

This is one of those posts thats unfortunately inseparable from who its coming from. For those not aware, Josiah Zayner is, to put it mildly, a controversial figure. He's best known for injecting himself with CRISPR. I find it interesting that he now claims he knew about CRISPR being hype from the beginning considering how much money he made off if it in the meantime. There's this idea that the word "biohacker" describes people who are more style than substance, which is unfair, but also not unwarranted given the examples the public often sees.
That's because upvotes aren't a true proxy of how valuable a comment is, it's also a proxy for other things like "does this comment provoke thought or further conversation?"
I've never felt like life has no joy in it, I'm highly motivated to achieve my goals and I think they're worthwhile goals.

The thing is, I think I won't achieve those goals, and that makes me anxious, not medically anxious, but there's this constant felling of dread.

So, I wouldn't say I'm depressed, but I have this constant dread that accompanies me everyday.
Teach X in Y Minutes
Love it, I just not gone use anything with BTRFS. Any chance I can get the same with ZFS instead?
You're awfully confident that this data is for ads despite absolutely no evidence whatsoever of any kind to support that.

Notice that Apple is also sending data? Is that also for ads? Should we be breaking up Apple, too?

This is almost certainly related to boring things like checking for app updates, and less boring but still controllable usage & diagnostic data (Settings > Privacy > Advanced > Usage & Diagnostic).

It's mostly just that Google, and realistically all apps, need to be far more conservative with cell data use than they are. Many developers forget it costs money and isn't infinite in amount.
I would argue that the internet as we know it today would not exist without the American 1st amendment. If that ever goes away, the internet as we know it today will no longer exist. The majority of the worlds hosting companies are here and there is a reason why people throughout the world use a vpn just to have simple online conversations that we freely enjoy.
I really appreciate it! Finance can be a really opaque topic and there's a lack of rigorous yet straightforward material about the subject.

Most information about trading either falls into the total bullshit camp designed for idiot retail investors, or complex papers/books designed for academics or professionals.

My blog tries to straddle the two: providing rigorous material but geared to those without a background in finance.
I dont think the poll should show the options in random order considering they're ordered in terms of frequency, it makes for a confusing setup
Election?

News that covid can cause neurological deficits in 20% of infected + increased rates of infection?
This is actually a pretty standard question by psychiatrists. It's because the DSM-V criteria for Major Depressive Disorder is "Depressed most of the day, nearly every day..." - and it's one of several other features you have to match within a 2 week period to match it.

It's a fancy way of saying "The unusual depressive episode (which can be normal) has lasted at least two weeks (not as normal)". How that exact number was determined I'm not sure (though it was the APA), but that's the standard everyone follows.

EDIT: I believe a variation of this question is standard as part of the PHQ-9 which is a screening/benchmark quick self-assessment for depression.
Worth also mentioning smaller game engines for devices like the GameBoy (Color): https://github.com/Zal0/ZGB
Haha my intention was less "northern hemisphere master race" and more "hey I know you already know this but remember that the change in season can affect your mood"
Zoom isn't malware, Apple did not revoke Zoom's Developer ID certificate, and indeed Zoom still exists on the Mac.

Zoom had a serious uninstaller bug, but that's all it was, and it's not relevant to the current discussion.
You get industrial grade security solutions out of the box with many Linux distributions. You get namespaces, firewalls and seccomp for free with any Linux kernel, and any Linux system with systemd gets unprivileged containers and sandboxes for free, too. AppArmor exists for MAC, and there are userspace sandboxes.
Great point.

My cousin grew up in a nice northern jersey suburb. Circa 2003, everyone in her circle was trying to get into the same 6 schools to be a doctor or investment banker.

It was weird but rational path to achieve a similar lifestyle. Of course my uncle was an accountant and my aunt a social worker... they bought into suburbia in the 80s when you did not need to be a doctor!
Some industries take decades to establish, you don't have 5-year stock of CPUs and you will probably be left high and dry if the supply is cut off by a natural disaster or something.

Where do you even get people with the knowledge required to run the 5nm fabs, there night be none at all on thr continent.
I've heard it said that the reason Pizzaro was able to conquer the Inca Empire with so few men is because of writing, meaning Pizzaro had access to a thousand years of military history on what worked and what didn't. (While the Incas did have writing, there's no evidence they had a written military history.)

The Roman army could beat a barbarian army that was 10 times larger and better armed, again due to studying military history.

Knowledge of military history also appeared to play a decisive role again and again in the battles between the Colonial/US armies and the Native Americans.

Either study war, or get beaten badly by the army that did.
And if not for our medical system people with Down syndrome would die to natural selection.
Baseless HN conspiracy theories about privacy never cease to amaze me.
Lol it would be hilarious if it turned out they were letting their is&t department work on OSX.
https://en.wikipedia.org/wiki/Hosts_(file)

If you want to block something use a firewall.
The US elections were in the last two weeks, the pandemic continued to get worse in Europe and the US, and Pfizer / BioNTech's vaccine news came out in the last two weeks.

Maybe the parent was considering the potentially depressive nature of facing lockdowns again.
Why Everyone Should Learn to Write
Think you'll find it hard to find a reliable generalist primer, but there are plenty of singular examples to consider and find interesting things.

1 - Book: A Bridge Too Far - until Cornelius Ryan wrote the book in 1974, operation Market Garden (WWII) was regarded with somewhat muted, neutral or positive outcome, the kind political leadership wanted to bury and did for decades. But his book detailed just how horribly disastrous it went and how out of touch commanders ended up being in their planning, tying confidence to their egos. An example of one thing that went wrong, they landed some 35,000 paratroopers in the operation and the British group's radios had an effective range of 3 miles, but the groups that needed to talk to each other were landed 8 miles apart. Another part of the plan called for a group to head down a road to join another contingent for the next step, but didn't accurately estimate the road's capacity or how clogged it would get and how long it would take for them to make it - which ended up being 3x+ times as long, obviating their combat role.

Takeaway: that muddy terrain thing you mentioned is pretty important. Also, a realistic sequence of events.

2 - twenty year-old commentary: a retired colonel's reflection on Arab militaries and ineffectiveness of military advisors/trainers in Arab countries. http://americandiplomacy.web.unc.edu/2000/12/why-arabs-lose-...

Takeaway: western countries keep ignoring cultural differences, sending off military instructors and advisors in waves after waves and expecting a particular unrealistic outcome from the effort.

3 - find your own rabbit hole on various information and writeups about all-women antiaircraft teams in WWII. Short version, British women could do maintenance, spotlighting, loading and aiming but were not allowed to pull the trigger because only men were allowed to shoot at other men. By contrast, Russian AA all-women teams were allowed to. Here's a starting point that just barely touches on this very-fascinating subject and shows how wide it is - https://www.iwm.org.uk/history/the-vital-role-of-women-in-th...

Takeaway: German pilots had their opinion of the matter, and they much preferred the British solution.
Imagine how worse off the world would be if everyone thought like you
>as a professional embedded developer.

>there's no screen on a microcontroller so printf("hello world") does nothing.

I'm going to take a very straight jab at you here and say that even if you are working professionally, it's in a very specific and not general way and you have been doing the same thing for quite some time.

As another commenter already mentioned, it is the most basic of things to have printf go to UART and to your monitoring terminal, and actually it tells us a lot that you are assuming that printf goes to a display on the device of all places! And that there can't be a screen on a device.
Out of the loop: How does this compare to MS Windows telemetry?
A small business like that is likely very, very dependent on its owner. The owner may be a slave to his customers. The employee can just walk away.
I am disappointed to see how some comments jump straight to "we shouldn't single out individuals", "his parent helped" or "yes he did X but Y is on another level altogether".

This really feels like some here should work on themselves to see why they feel so personally threatened by the achievements of a 13 years old. Even with the help of his parents (which we have no indication of) this is a good inspiration for other younger of our community that feels some knowledge is out of their reach.
Current world is not post-scarcity. However, there is a point where marginal value of “extra” stuff is essentially zero. When everyone can be at that level is what I mean by post-scarcity.
It doesn't help that there's also cultural differences. I've been in a similar turf war between an Israeli team and myself as an ex-Israeli on a different team and there was just a huge gap in how things are done. Both teams could have probably delivered just fine but top management is what really messed things up. So really this is probably mostly lack of leadership, and the turf wars are more of a symptom... The lack of leadership is often not just in being unable to resolve/deal/manage a larger org. but also the hiring of more managers who are unable to do this stuff that eventually get promoted to positions where they end up doing more harm.

I'm not sure the engineers themselves having a big ego is a negative. I'd want a team who thinks they can do anything. But how you manage those guys is the problem...
Remote work is not for me. I'm struggling pretty hard. I miss people. I miss my sense of being good at the parts of work that involved people. I'm shit at working alone. I'm not productive like some are, and all my best assets were how I could support people around me and help them love what they were doing. All I have left of work are the parts that make me feel badly every day.

Fuck this pandemic.
I get depressed for 5 / 15 seconds once every few days. How do I respond to this poll?
It makes sense in general, otherwise there's bias towards the top of the list. It's just this particular poll it doesn't work for.
It's always going to be more efficient to feed grain, soy etc. directly to humans than it is to feed those crops to cows then feed cow meat and milk to humans (you lose about 90% of the crop calories creating beef: https://en.wikipedia.org/wiki/Feed_conversion_ratio). People arguing the opposite are usually under the false impression that cows are only fed grass (there's no enough room for this for the amount of cows we need) or arguing corner cases.
>I'd say a lot of UARTs are running debug consoles

You are already assuming RTOS/Linux with this.

UART is easy to initialise on about all platforms. On an AVR you you don't even have to think about configs or clock trees.

UART is one of the best ways to debug and vastly superior to just blinking a led.
Do you mean “all but” literally (everything except confirmed) or colloquially (absolutely confirmed)?

(I hate the term “all but”. I find it often hard to tell what people actually want to say when using it.)
Thanks Dan. I appreciate you trying to keep the conversation sane.
In hindsight your early 20s are a lot more fungible than it seems at the start. 20-25 you can really do a lot of the same things. Heck, even your 30s you can do a lot more than you think you can when you're looking forward from 20.

Also keep in mind that everyone your age is in the same boat this year.
You seemingly make a strong, baseless, and unscientific ontological claim, saying that we have one set of mathematical formalisms in our theoretical model that are "really real" and others that are not "really real". Surely the word "virtual" can no more be used to support this claim than the word "imaginary" can be used to distinguish the reality of real and complex numbers.
> "We have cooked a whole egg."

That's pretty incredible. Does randomizing the nodes make it less dangerous to microwave metal?
I did my part: I read the article. I still have zero clue as to how evaluate whether any particular call will warrant this new or the previous, alternative approach.
Network effects, mate. I'm in the same boat. Zoom/hangout meetings just aren't the same magic as walking down the hallway and knocking on a door/cube.

There's still nothing widely used that compares to a whiteboard, either. Drawing tablets haven't caught on yet.
No sophistry there. Just mild fun word play, of the hacker and Zen schools kind (which are kindred spirits). Check out Steven Levy's book Hackers: Heroes of the Computer Revolution (the early chapters), ESR's compilations such as The Unix Koans, the Gateless Gate, etc.
The perception of things being untrustable (and that it's coming down the pipeline) is what will break larger society. If people are expecting deep fakes to arrive, we'll start seeing the knock-on effects of that erosion in trust waaaaaay before even a fraction of the risks are real. (imho of course :)
What ? I suggest trying for yourself. This is a 3 step UI workflow starting from scratch and can be done in within 15 seconds, assuming you are comfortable with the Windows UI.

Its definitely easy. EDIT: or is this sarcasm ? difficult to tell.
> Perhaps they'd say those are the simplest, purest instantiation of a frequency.

Actually I thought it is the other way round: A frequency is defined as a sine basically, it has an
* amplitude
* frequency
* phase shift

The phase shift is why we need cosines and sines in the Fourier transform as cosine is just a shifted sine.

The frequency is the constant in the argument of the sine. And here is where the tail might chase the dog: it's the definition, not an observation I'd think.

> When performing a Fourier transform, we represent the signal in a new basis, where each component

... each component is a sine, that is described by the 3 constants above.

> In simpler words, it comes down to the barber pole illusion. If you rotate a spring-shaped 3d curve, it looks as if it was traveling upwards. And the 2d projection of the spring are Sines and cosine.

Exactly, a complex exponential function is just that spring. And if the absolute value of the argument is not exactly one, the spring spirals outwards or inwards.
There's various tiers of private jet service, from NetJets at the top to Wheels Up at the bottom.

I would compare Wheels Up to a condo timeshare, kind of.

You would have to do a fair amount of research to decide if Wheels Up is worth your while.

The Good

- smaller planes means cheaper flights

- two pilots

- the social features allow interesting things like common destinations and airport transportation, which would be great for sports fans, etc.

The Bad

- it appears Wheels Up is trying to package seats with multiple clients on the same flight (not so private)

- most of the planes aren't owned/leased by Wheels Up

- NetJets has a working business model, most smaller services don't

- $15,000 first year (plus time), $8,500 second year (plus time)

Source: commercial pilot who follows the trade press.
I'm not sure the Cheshire Cat was really extolling the virtues of knowing where you want to get to.
They may offer resistance to the control of the second group but they don't fight as hard to take that control (because they focus on doing the work) so are eventually overpowered
> Neither Microsoft

I see more nuance here. I don't trust the Apple/MS licensing / code signing teams, but I do trust the MS defender team to do much better job. They're not directly connected to a source of profit.
Good luck and feel free to reach out for an impromptu chat
That’s not depression - you’re experiencing sadness.
https://en.m.wikipedia.org/wiki/Media_cross-ownership_in_the...
I'm not aware of any interesting thing that Cairo can do that Skia cannot, and Skia definitely is more expressive.
Hi! I'm happy to chat if you like! I agree that meeting people is hard, it felt easier when then internet was younger. I'm jackbravo on twitter or linkedin.

Also, you won't know if the bridge is really burned until you try to use it.
I think there's been one project I worked on that had a UART hooked up to printf, usually the pin+code overhead didn't make sense.

LED or Logic Analyzer are usually where I lean before reaching for printf.
Thank you and I wish you well Google News
Poll: Do you think the 2020 US presidential election had widespread fraud?
Do you think the 2020 US presidential election had widespread fraud?
Agreed - there's no professional ethicist quoted here and the argument seems to be against abusive pet breeding and keeping practices. Absolutely, people should stop giving money to puppy mills. That doesn't mean people should stop having pets altogether.
Trials take a long time but some early results are pretty amazing. For example for the Thalassemia & Sickle Cell trial we actually have patients that have been treated with great results https://crisprtx.gcs-web.com/news-releases/news-release-deta...

Physicians running the trial claim that these diseases are basically cured in some patients: “I am encouraged by the preliminary results, which demonstrate, in essence, a functional cure for patients with beta thalassemia and sickle cell disease.”

This is just the beginning. The article is clickbait, or worse, totally misinformed.
^this. refactoring into React or any tech stack does not correlate directly to user engagement or revenue. It sure does have impact; but perhaps it's more relevant to state something like improving page load time, developer productivity, time to market (or MTTR, etc) because of cleaner architecture that enables to iterate faster and so on
I don’t think so. Sure, the Emerging Technologies division was shut down, but most of the Gecko team was left intact.

(I am a Mozilla employee.)
If you want someone to talk to I would be happy to chat. Contact info is in profile.
It's not about freedom it's about the fact that those computers cost thousands of dollars and every year Apple wants more and more control after I already gave them a huge wad of money. I am not upgrading to Big Sur, I didn't upgrade to Catalina either, but not upgrading creates its own complications in the long term.
Anxiety for sure. Not depression.
/r/parlerwatch is a bit of a mess, mostly examples of extreme right wing posts, but I believe there are a few examples of people getting banned.
Damn, that's a shitty hand you've been dealt. I hope you find your luck turning around, and I hope you can allow yourself to operate at 10-20% without too much judgement; an individual can only accommodate so much at once.

Thank you for sharing this on HN. It's always good for us, as a community, to acknowledge the less ebullient, bullish sides of our lives.
if this is about covid19, the asia pacific is curious why.
I was there too. That would be the ecache problem, right?

I was in the service division at the time, and yes, it was a serious issue. However, if I recall correctly it was limited to the E10K. It was the flagship machine, so of course it got all the attention, but most customers didn't suffer from it.
Same could be said for a wood chipper.
My current microwave (a Miele) has the time dial. It's not as simple as the Argos, but I basically don't touch buttons on it otherwise. If only it didn't have the clock built in.

My second best microwave was a Samsung. It was terrible in the way all Samsung products are EXCEPT it had a "sound off" button so your microwave didn't wake the whole house when it finished cooking your 1:00am burrito. After about 3 years (standard for Samsung products to become garbage) it stopped working and I replaced it with the 3 year newer model that didn't have the volume kill switch.
Indeed. I wish there was more nuance here. This has been the second worst year of my 39 years on this planet... but, with that said, I'm not depressed, just kind of shitty.
Someone should calculate the bandwidth required to run an even cooking pattern, and then strongly encourage all manufacturers to share the same narrow band.
But he was a drug dealer as well not just a "weed smoker". He died from an overdose of the drugs he was selling so waving this all away by saying there is no effect in looking the other way to violent crack dealers who are printing their own money is not a winning argument sorry.
> Facebook is not "the internet worldwide"

It's really not that simple. For most people in many countries[0], FB is the only internet they have. It comes packaged free with their phones.

[0] I believe, dont have exact figures. I know from experience that it's true of a large majority of people in the Philippines.
Since there's a link to 'unvote' next to the option that I chose, I can only assume that this poll is not anonymous and that my choice is stored with my username somewhere on HN's server.

It could also be cookie-based, but something to keep in mind if you have privacy concerns.
Power-free system harnesses evaporation to keep items cool
https://blend2d.com/performance.html
The official benchmarcks show that blend2d isn't significantly faster than QT or Cairo renderers and it is common wisdom that Skia often order of magnitudes faster than them.
I talked to the blend2d author ~ a year ago and he will not publish skia benchmarck until it's new "more parallel" version of blend2d is ready which imply he is skeptic that current blend2d is competitive with Skia.

Fastuidraw is the only renderer to have shown benchmarcks outperforming skia but it is mostly unmaintainef today and the benchmarks weren't representative
What is this "invoice" payment method? Do they send you the product and also a bill for it?
Anyone who thinks they even might have SAD should get a daylight lamp. LEDs are so cheap. You want at least 100W of real power draw, 5000-6500K color temp.

You want em about 2-3 feet away, about 45° off-axis to minimize glare and maximize activation of intrinsically photosensitive retinal ganglion cells (ipRGCs). I keep mine on a cheap tripod behind my desk.

I have some LED floodlights, flat panels with a mounting bracket. ~$60 for 200W. Just as an example:

https://www.amazon.com/Onforu-Waterproof-Floodlight-Playgrou...