skysight-inc/HackerNews huggingface dataset:
You don’t need CRISPR for sex selection—-it can already be done as part of the preimplantation screening for IVF.

For the other things, the best editing technique in the world is useless without a known and well-defined target. Intelligence is certainly partly heritable, but it’s not like there’s a single switch that needs to be toggled: genome-wide association studies find hundreds or thousands of linked genes—-and many of them likely have multiple functions. I would bet over-expressing any single one of them leads to many, many more problems than it solves.
Commentor I replied to did not write +1. 0800 is also a likely prefix for such a helpline in the UK, for example, probably many countries.

(But really it was just a facetious comment to highlight that 'national' is pretty useless on an international website, without context to help anyway.)
Cooking entire meals by using a microwave was a trend sometime during the 70s or 80s so check out the cooking book shelves in a second hand store or eBay.
If it wasn't clear, I'm not disagreeing, I'm looking for examples, or other reasons for that belief

Edit: The note I think about it, the more I'm inclined to disagree after all. A $500K McKinsey employee is not an entry level consultant. They are likely leading a large team and working regularly with C-level executives at enterprise businesses. They are going to have presence and gravitas because credibility is a huge part of their job.

What kind of business does $200K in revenue per year? It's very likely to be a sole proprietorship, maybe 1-2 employees at most.

I realize that there may be cultures and subcultures that truly believe the independence of the business owner makes them more respectable (although I personally believe that independence is a bit of an illusion), but I think more people would subconsciously assign a higher status to the first person and that it probably wouldn't be close.
The prognosis for depression is excellent when the right help is given.

It's a shame on humanity that the prognosis is poor.

I was, what I thought, a special case of depressed. No hope of recovery. Hell, I didn't even have depression, it was just who I was inside! Constant terrible thoughts about myself and every day a torture. But it got better. It got sooo much better. Life is beautiful and I'm excited to live it.
One problem I have with Arduino and such is that they sell their products as educational toys, and thus unsuitable to incorporate into any serious product.
Good luck making Breaking Bad with a permissive license.
An analogy I like to use is prime vs zoom lenses on DSLR cameras.

A common observation by professionals is that when they have a zoom lens attached to their camera, the pictures tend to be either one extreme zoom or the other. That is, they wanted "as much as possible" and just set the zoom range to the maximum in that direction.

Which means that most of the zoom range is (almost) never utilised.

The big advantage of prime lenses is that by sacrificing the ability to zoom, the quality can be better. A 35-50mm zoom is never going to be as good as two separate 35mm and 50mm prime lenses.

So if you want to maximise quality, get primes.

But then your camera bag will be heavier, and your wallet lighter.

Also, you now cannot have any intermediate zoom range in those rare times that you do need it.

So there's always some trade-off being made.

Languages like C++ are like zoom lenses. They allow almost any programming paradigm, and various mixes too. You can have a procedural program with memory safety, with functional bits thrown in, and call out to unsafe C code if you want.

Languages like Haskell or JavaScript are like a prime lens, with a lot of decisions fixed at one extreme or another.

I suspect that what's needed is the zoom-like flexibility of languages like C++, but with defined subsets that work more like a "prime" language. With physical lenses, this is impossible. You can't take the zoom bits out, leaving the prime behind. With software... I think it can be done.

This isn't that unusual an idea. Mainstream languages are already slowly converging on this concept. For example, C# has a project-level "unsafe" flag, which turns a set of language features on or off.
The loop argument makes no sense at all. HTTP is being used as a transport for a base64-encoded payload, the actual process of veryfing the validity of the developer certificate is done by the service behind that Apple URL - not by the HTTP stack.

There is no justification not to switch to HTTPS here.
I am also surprised by the numbers. At first I thought numbers would be lower.

I wonder if an equally useful question is “were you ever depressed?”

Im interested in seeing if there is an overlap of those that answered no. If they’ve overcome their depression and more importantly recognize what real depression feels like for them.
Do you have any links to more information on this? Sounds interesting.
It's hard to argue against what Google has accomplished in the last 20 years. But in my Bay Area social circle, working at Stripe is considered more prestigious. These days Google is big, boring, bureaucratic, and maybe a little evil. Stripe is successful, growing, pays at least comparably well and has way more potential financial upside. They're also known to have a high hiring bar and a great dev culture. I've heard nothing but good things about the company or the people who work there.

- an ex-Googler with friends at Stripe
I think there is an essential difference between "you have to do X because it is mandated" and "you practically have to do X in order to keep up". For one, the latter scenario is essentially more democratic than the former, it first requires some critical mass of people voluntarily (in the strongest sense of the word) deciding that they are better off with X, whereas the former may only require a decision from a relatively small number of authorities. This puts strong restrictions on what X could possibly be: for example, you would never have people sterilizing themselves because some critical mass of other people are sterilizing themselves. I will also point out that your argument applies to technological progress in general and is not specific to gene editing.

EDIT: I may have misunderstood you, I interpreted your comment to be about the hypothetical scenario where most people have genetically modified themselves into being "super heroes" and now the people who haven't can't keep up with the rest of society, so it becomes a practical necessity without being legally required. On second reading though I'm not sure if that's what you meant.
Agreed.

I would have replied earlier, but I've been digitally detoxing for the last few months, so I'm fairly inactive.
Many old methods are great! The point is that not all old methods are great. Fields move forward one funeral at a time, and there do remain a lot of aging researchers who are stuck in the past. This is not to say that every old researcher is doing a bad job or that every military historian is doing a bad job... it just seems to be the field that has resisted progress the most.

I obviously don't have a full view of the field, but I do know a few military history faculty in their 30s and they don't view themselves as pariahs. They also scream at their laptops when terrible scholarship ends up flying off the bookshelves because bad military history sells like hotcakes.
Perhaps we could make a similar list for FPGAs. Or for more complicated systems like Nvidia Jetson.
> they make new law all the damn time

I know they do, but they're not supposed to. That's the point I was making. See below.

> there's is no written definition of murder in Michigan

Yes, that's true of many common law crimes in many States. And where those common law crimes existed before any of the US States were formed, those States often continue to accept the common law definitions of the crimes, as developed over centuries of Anglo-American case law. That's not what I am saying is a problem.

What I am saying is a problem is when there is a statute that makes specific law, but courts then "interpret" things into the statute that were never there and never intended to be there by the legislature that passed the statute.
Over that time, you could populate a good portion of nearby systems. It would only take 1m years for humans to populate every possible planet in the galaxy:

https://www.learnastronomyhq.com/articles/how-long-would-it-...

Plenty of room for a very large economy. The next galaxy would take some doing though since it is 2.5 million ly away.
This is what I was curious about, though I'd like to see what they actually posted and whether they got banned for the speech or for harassing people or other behavior like that.

/r/TheDonald was notorious for brigading other subreddits, manipulating votes and other TOS violations then crying censorship when they got banned.
I'm surprised from this checklist because this checked almost none of what I would be looking for in a as a professional embedded developer.

What I would like to see:

How easy to push the software from the computer to the microcontroller? Preferably you should be able to push the firmware over USB or something like that in a few seconds. Don't mind whether that's a command line tool or a button in the IDE but there has to be something and it MUST work.

Is the tool friendly to source control? I had very bad experiences with embedded tools automatically creating hundreds of files all over the project and editing them on every build, causing a massive headache to store the project in source control. Note that software developers expect their development tools to support source control natively but I have no illusion of that happening in embedded IDE.

How easy to make a simple software and how is the documentation? For reference the basic in EE is to blink a LED, the microcontroller should provide API with documentation and examples to do that (and much more). It's shocking how many MCU have zero doc and the little there is doesn't work.

Personal note: It's funny the author wants to compile a hello world because that's not a thing in embedded, there's no screen on a microcontroller so printf("hello world") does nothing.

Last. I'd like to know about debug capabilities? Can you connect the computer to the MCU and debug directly on the device? Ideally there should be a full debugger including breakpoint support and step by step execution and displaying all local variables. The debugger should also be able to show debug output from the microcontroller (output from printf or equivalent).
The easier it is to opt out, the more likely it is for sketchy developers to guide tech-novice users through that process, the more likely it is for malicious actors to take advantage of those who opted out.
What is the compatibility of Citus and Timescale?
Its not illegal, Its in the banks fine print that states that you will not allow another to control your card.

If you do that and it gets abused the bank wont cover you, you'll be liable to pay up whatever the abuse was.
Apple isn't just Macs. iPhone has 50% or greater market share in the USA. iPad has 65% or market share as well. Apple certainly does exploit a monopoly in various different ways. One is their monopoly on browser engines in iOS that lets them dictate web standards because if they don't implement something then the 1.5 billion iSO devices don't get it period.
Apple iPhone 12 Pro Max Camera review
Unexpected detection of SARS-CoV-2 antibodies in the prepandemic period in Italy
And you’re going to get a lot of that with 2 tonne EVs compared to lighter ICE cars.

You can fit particulate filters to the exhaust to capture the tiny particles there. Gonna struggle with the tyres. Make them harder and then braking distances increase and the car will struggle to turn(efficientcy will go up though) , chance the compound so they come apart in bigger chunks then the tyres won’t last as long and you’ll end up with loads of rubber in the drains.
Maybe we’re talking cross purposes here because I generally save a large % of my paycheck. So if an emergency came up (and I was still employed) I would just save a smaller % of it.

But regardless I’m just saying you can use a credit card to buy time interest-free before you pay off the emergency with your salary/stocks/whatever. It’s better than taking a margin loan, no?
Presumably a subchannel in the 2.4GHz frequency range that said microwave wasn't spewing as much interference on.

https://en.m.wikipedia.org/wiki/List_of_WLAN_channels#2.4_GH...
> The argument that its all about 'culture', like in so many other fields is a very questionable approach.

That isn't the argument. Cultural history is indeed trendy, but the bulk of new writing is not cultural history.
> There are obvious security advantages to app signing. But there are also negative implications for privacy and availability.

App signing exists elsewhere without sacrificing privacy. Most Linux packages, for example, are signed with GPG keys. The difference is that Linux only cares about installing trusted packages. It doesn't care about applications that are already installed after verification. Apple insists on having the ability to revoke something that's already installed. There are two issues here:

1. Is it reasonable to revoke permissions for an installed package? It could be argued that it will help stop malicious apps that were discovered after they were distributed. However, it could equally as well be that Apple wants more control over devices and hold developers to ransom. Their recent treatment of developers indicate that this concern is not at all misplaced. The least Apple could do is warn the user about a revoked certificate and ask if they still want to proceed (like how browsers do in the same scenario). However, it just refuses outright.

2. Apple chose a very bad method to implement online certificate revocation. OCSP is meant for server certificate validation. OCSP stapling is preferred over plain OCSP due to privacy concerns. Stapling cannot be used in this context. This method unfortunately ruins privacy and spill user information everywhere. They could have chosen some other more private method, like an updatable CRL.

> I’m pretty sure those who relentlessly focus on the possible downsides don’t know either.

As I said, there are more private ways to push revocation status. Apple always claimed that the device lockdown was to ensure privacy. This oversight shows how hollow that claim is.

Important part to notice is the false dichotomy of freedom vs security. The argument that negligent users will screw up if given freedom. This is wrong for two reasons:

1. Defaults vs restrictions: Keep the defaults secure and slightly hard to modify for normal users. But don't restrict those who need alternatives.

2. Security can be achieved without locking everything down and remote controlling it. See web browsers for example. We run JS from all insecure sources, but cannot access sensitive resources (like camera, file access etc) without users' permission. The same can be achieved on OS with sandboxing, microkernels etc.

> no one is held hostage or abused in this scenario

Abuse is not always apparent to the abused. User rights are gradually eroded away in the name of security, giving users enough time to get accustomed to it. There may be escape hatches now, but they are slowly getting closed. For example, we considered PCs that don't allow us to install another OS as abusive. However, we don't hold mobile devices to the same standard. Unfortunately, this normalization of abuse doesn't just affect those who accept it. The rest of us are left without a choice. That criticism is definitely valid.
After cat sitting for a neighbor recently, I've been seriously considering adopting a pair of cats :)
Are you depressed?
>"Turns out, no, macOS is still written by the same old skeleton crew at Apple"

I didn't understand this reference. Who is the "same old skeleton crew"?
Seconded. Though I can't remenber an offsite poll either until this one.
Workers may, indeed, offer resistance against the second group.
I recently picked up the 1834-1842 issues of Journal Des Armes Spéciales which was a French technical journal about arms and armament. ( https://aaronnewcomer.com/document/journal-des-armes-special... ). An article introducing it gives a pretty good reasoning for the importance of studying military history, translated:

“Let the lessons of history not be lost for us, that the progress of military art is marching in concert with those of the industrial arts. If we are richer and more enlightened, let us also be stronger and more valiant. Let us not let this sword rust in our hands that Brennus and Clovis left us, that Charlemagne and Napoleon walked all over Europe; then all the tyrants and all the barbarians of the earth will not prevail never against a nation that can present a compact mass of eight million men, ready to pay their blood for the defense of the fatherland.
It is for the purpose of contributing to such a glorious result that we are undertaking today the publication of the Journal Des Armes Spéciales. Happy if we can contribute to maintain among the French, the sacred fire, the taste for arms that have always distinguished our ancestors; if we can root out these alluring doctrines, but disastrous, which tend to effeminate one whose people will always be passionate about war, and who will always support or the terror of Europe. The more the sweets of peace take root in the heart of our statesmen, the more the taste for peaceful pleasures tends to spread, the more gold finally gains consideration among us, the more urgent it is to return the honors due to it to the iron. Then the French people, drenched by the revolution, will again travel fourteen centuries of existence; if he conquers, they will be peaceful: he will have allies, friends and no subjects; it will use force only to resist an unjust aggression, to defend its allies, to avenge the injury done to only one of its citizens, and if some reckless enemy were to challenge in combat the great people, one would see reappear the great army more numerous and more formidable than ever.”
maybe there's something like this buried in the fine print, but I don't think anyone in the US worries about this. I certainly don't. the usual way a transaction goes is you hand the employee your card and they swipe it for you. in any case, it makes no difference whether you wait to get the receipt first for a meal. either way, you are handing them the card and they are swiping it outside your field of view.

credit card issuers heavily favor the customer in disputes. lots of people unknowingly make chargebacks in situations where it's actually not legal to do so. it still gets processed, the customer gets their money back, and the merchant eats a punitive fee.
Tomorrow's another day of trying to get better. It's not who you are, it's an illness that can perpetuate and dissipate. Every day is a project to get closer to the latter. Talking helps a shit load, but friends and family can't help you as much as you can, and the talking is you helping yourself.
I'm not depressed, the weird effect the pandemic has had on me is that not much really changed for me. I do high power rocketry for a hobby so i haven't been able to attend launches but that's about it. I don't get to eat out but my wife and I both have been wanting to stop eating out for a while. I've always been wfh so no change there either. Kids are home more doing school through zoom but that's not a big deal either. :shrug:
> I expect Apple to take the opposite path, not immediately, but eventually: disable sideloading and enforce a Mac App Store only policy on macOS, similar to iOS

Yep. And when Apple does it, HN will celebrate. There's a certain type of person who's terrified by independence and freedom and who craves the comforting safety of rules and control. macOS will be the OS for that kind of person.
When IBM didn't like the panels they could source for Thinkpads, they started a new company called International Display Technology to manufacture panels they did like. Thinkpads used to be special.

While it's entirely possible there's a connection between decisions like that and IBM's PC division being unprofitable enough they sold it to Lenovo, it might be reasonable to hope that Lenovo would make the effort to offer competitive panels when it's obviously possible for their competitors to source them.
I think it's easy to fall into habits with appliances, whereby we artificially limit our use cases to safe / common ones.

I found an Oster blender recipe book from the early 60s with recipes for all kinds of food prep... in a blender. Baking mixes, egg dishes, etc.

Sure, part of it was marketing, but it made me realize how much familiarity circumscribes imagination.
You’re welcome to email me if you want or need someone to talk to (in profile).
Not sure about this. Only if they're sure the dog will be well taken care of, rather than a burden.
I disagree. When hearing Americans talk or in American media its not 'raw raw nationalism' its more like 'the army is really good and you should always honer and support them even when shitty politicians give them shitty jobs'.

The amount of deference to veterans and how they are all heroes is not about nationalism or chauvinism, its about the genuine believe that everybody who served in the military has served the country. Saying anything against the military is often interpreted as a direct attack on veterans and soldiers. Giving out metal before ever sports match is not exactly normal in most of the Western world.

The people in the US have a incredible deference to military, they trust it more then almost anybody else. The military as a institution specifically, not the nation. This is true even for people who have no trust in the presidency, congress or literally any other federal institution. Consistently the military is the most trusted institution.

Even people who are not very nationalistic or chauvinistic almost universally support the military, are happy with or want to increase military spending. Decreasing military spending in US politics basically gets you labeled as a traitor and despite people voting for anti-war candidates, they don't vote for 'reduce military spending candidates'.

All this without people even having the slightest understanding of what the military does and why. This goes even for politicians, most couldn't tell you the difference between Sunni and Shia or point out Afghanistan on a map. That of course doesn't matter, all that matter is that we are supporting the bois, a couple 10s of billions for new <thingding> that help even 1 solider is worth the cost. Just never ever question why any of this is done in the first place, those boring details don't matter.

Something actual military history could help people understand, but that is besides the point.
I would like to ask the author about pricing:

If I create 20 monitors at a rate of 10 minutes I only pay $1.00 + $1.04 / mo

How do you create a sustainable product that you can realistic maintain when you've to pay taxes, hosting, etc. at this price?
"The market can remain irrational longer than you can remain solvent." -- J.M. Keynes

Also applies to competitors of Venture funded vortexes like Uber/Lyft/Doordash.

Sure, in the long run your cloud kitchen with guest chefs and nifty social networking features might be a more sustainable model in the long run. But you'll never find out because your effort will be murdered by Uber's marketing spend.
And when you've been severely depressed and get better, I argue you feel better than anybody who has never suffered with it.
Try using Pyre! It's open-source. I use it daily at IG.
And an electric kettle will boil water quickly and controllably (no sudden boil-overs), often in less time than a microwave.
I don’t see how you can so confidently reach that conclusion. It seems perfectly plausible that Apple wants a way to quickly quash malware, worms, etc.