skysight-inc/HackerNews huggingface dataset:
CRISPR is currently being used to treat human subjects in these clinical trials:

* Transthyretin Amyloidosis: https://news.yahoo.com/intellia-therapeutics-doses-first-pat...

* Lymphoma: https://www.healio.com/news/hematology-oncology/20201023/cri...

* Leber Congenital Amaurosis: https://www.retina-international.org/lca-10-clinical-trial-f...

* Thalassemia & Sickle Cell: https://geneticliteracyproject.org/2020/06/18/crispr-provide...

* Antibiotic Resistant UTIs: https://www.medpace.com/the-first-controlled-clinical-trial-...
> Why are Google and Facebook so attractive to prospective engineers while Stripe and Nvidia are never brought up?

This has nothing to do with prestige and everything to do with Google and Facebook having 100 times the headcount. From my experience, unicorns actual tend to be more selective than FAANGs (except maybe Netflix) even if they don't pay any better.
My views are likely aligned with Taibbis politics. But my experience on Wall Street makes me think he’s untrustworthy. His stories routinely misrepresent how things work to make points.
As someone who has suffered from depression in the past, I'd like to borrow Steven Fry's words on depression:

“You don’t get depressed because bad things happen to you. . .depression is something that happens like weather to you, it’s inside you. . .it’s not enough to talk yourself out of it by saying, ‘but I shouldn’t be depressed because I’ve got people who are nice to me’. . .It’s very important, at least to get that stage of it out of the way, to recognise it as a mood disorder, as something that is akin to weather.”

I feel like there is a lot of confusion between "Shit Life Syndrome" and depression, and to the people suffering from either I'm not sure the difference is much of a consolation.

I had to put down my childhood dog down today. He was with me every day throughout my depression. It's awful, it hurts and I'll never be able to replace the role that dog played in my life. I don't feel depressed though, I feel distraught.

I'm lucky enough to have lived an incredibly privileged life, with a stable family, excellent education and opportunities etc. so today is the worst I've felt in ages. With that in mind, I don't feel like I can lay claim to even "Shit Life Syndrome", I live in a country that has nearly eradicated COVID, I have a strong support base among family friends and coworkers.

With all that in mind, all I want to drive home is that if you're depressed, you don't need a reason. Though if you do have reasons you could have depression or you could not (I'm never going to tell someone the way they feel is invalid), either way I hope everyone out there is looking after themselves as best they can.
This post looks like a promo for that site, and likely they're setting a ton of tracking cookies and sell our data to a ton of advertisers
IMO especially when stock holders wanting a monetary return on investment are involved. I give my money to the FSF every month, because they provide value to me, but not because I expect them to surreptitiously extract it from others and give it to me as cash dividends.
I guess if you are looking at this solely from the perspective of using it for gene editing and "curing" disease, I would agree that practical applications might be over-hyped.

But it is still a great tool for research. Many model organisms are now opened to transgenesis due to crispr compared to traditional methods. There was a new paper that came out on cas3 recently that showed a cool application in studying minimal genomes (https://www.nature.com/articles/s41592-020-00980-w). And there are also potential in non-in-vivo usage of crispr for general sequence manipulation.

Just because it might not be immediately useful for one over-hyped application, doesn't mean it is dead for all other applications.
The base appears to be $10k and you let Costco hold onto $7.5k of your money.
In fact, it was so negligent because Apple is actually secretly rebelling against the Illuminati, who forced them to do this, by making such a deliberate cock-up of it that it was discovered within hours of release.

We need to go deeper.
It's not as simple as chemical = good or bad.

The principle behind modifying the gut microbiome to achieve good outcomes requires the intestinal flora to change: that means, for example, that some bacteria must die and some bacteria must proliferate. This is one of the main reasons why curcumin (from turmeric), for example, is the subject of much research in the field.

Anti-microbial properties don't apply equally to all species of microbes, and such selective action is essential for modulating the microbiome.

Disturbances of the gut flora do tend to lead to poorer outcomes more often than not, but this is not a hard rule. It's rather that complex machines are fragile, and most modifications done in flight lead to adverse outcomes: without prior knowledge and generally speaking, it's a bit like adding or removing a random line of code in a large application.
Meanwhile one could of have this solved in their projects in less than the time it took to have this HN discussion and moved on with their life. Seriously, somethings are worth complaining over, others are not.
I use adblockios and haven't upgraded because they unblocked the blocking. I keep hearing about charles, I wonder if it is special or if it doesn't really block everything.
I'm assuming that the waiter salary/tip will cover delivery costs...

"Will" is doing double duty in that sentence. Maybe with some futuristic delivery tech (Rainbows End-style pneumatic cannons?) that would be possible. Today, delivery costs are covered by VCs and by paying drivers less than minimum wage. (58% of California voters approve!)
> If you catch malware in the wild you don’t want to wait half a day for the cache to expire.

But if you have a cached OCSP response for the cert of a malware author, then you've already launched their app, so it's probably too late.
It feels like there's fundamentally a tradeoff between "fast and flat" and "big". So basically I would guess NUMA and programming models that take it into account is the future.

And maybe software management of CPU cache.

I think wanting fast, flat, and big is sort of like wanting the CAP theorem to go away... "it sure would be great" if we could have an infinitely scalable SQL database without any programming model changes.

In other words, no matter how "fast" a memory becomes, someone's going to want it "bigger", which makes things slower.
If things get cheaper, you can live off less income from your investments .
No social contacts with friends or strangers who could become friends (or even a partner). So loneliness and lack of intimacy. The latter is a killer.
Without having to worry about a store front, you could consolidate kitchen equipment between businesses. Say you use your ovens in the morning to bake bread, and at night to cook meat. Sure, there are limits to this, but there have to be some benefits from centralization.

Another option for cost savings is on the fly demand pricing of meals. Through some process of ingredient availability, customer analytics, registered interest(voting or something), etc, the centralized kitchen could decide to make a particular dish at a greater volume/lower cost which could then be passed on to consumers. i.e. Tuesday is 'spaghetti night' and you can feed your family for 50% less than other options.

I believe this may be how many cafeterias operate. Cafeterias are a good analogy because you have an environment already saving on wait staff and gratuities.

This might seem odd to a typical HN reader who spends $300+ on sushi dinners in SF, but this sort of thing could appeal to many people with less income and without the time to prepare meals themselves. It probably won't work until we can automate the delivery process, but I think at some point the economics will work out in certain markets.
Amazon was a magical thinking! Google was a magical thinking! iPhone was a magical thinking! This article makes confusing arguments on sustainability and unsustainability.
they do all this on you iphone and watch, and even more.
It's absolutely ridiculous that Food Delivery apps aren't making gobs of cash right now.

(1) Restaurants are closed for indoor dining (or obviously should be anywhere they aren't). You literally can't sit in a restaurant in good faith, anywhere in the US today.

(2) The Food Delivery app prices are usually 5% to 20% higher than the in-dining counterparts.

(3) In addition to that, the order/delivery fees are much higher than all other competitors. (At least, on my app the 'delivery fee' from GrubHub is 25% higher than the equivalent delivery fee from the local Pizza Hut and Panera Bread, for example)

(4) And because of all of that, the default tip rates are also higher than all other delivery services.

(5) Despite all of the above, everyone is still paying for it. Paid-in-full delivery purchases are at an all-time high, despite all-time high prices for it.

(6) There's a massive record-high unemployment due to people who have lost their jobs from the pandemic! It's cheaper than ever to pick up folks as part-time drivers. And pizza places generally actually employ their drivers, delivery apps lie to the feds and claim their employees as 1099-contractors, cutting their costs even lower.

Sure, DoorDash's "efficiency" claims are all lies. But who cares, they don't need "magically efficient logistics" to make their model work, this model has already worked for every single random pizza place or equivalent from the past 40+ years straight.

These delivery-only-apps have the highest revenue and margins (while having the lowest overhead cost and lowest employee cost) of any food service business I've ever heard of. They've been handed the best possible scenario for their business. How they aren't wildly profitable right now is absolutely due to ridiculous management/financing shenanigans alone, and not because "ordering food for delivery via touch-tone telephone" is some inherently unsustainable business practice.
Only with your username does that get an upvote...
There are a number of specialized lines too depending on what an individual identified most with in their circumstance.

+1 (800) 273-8255 or text HELLO to 741741 National Suicide Prevention Lifeline

+1 (800) 799-7233 National Domestic Violence Hotline

+1 (888) 373-7888 National Human Trafficking Hotline

+1 (800)-422-4453 National Child Abuse Hotline

+1 (800)-656-4673 Rape, Abuse and Incest National Network (RAINN)

+1 (800)-985-5990 Disaster Distress Hotline

+1 (866) 488-7386 TREVOR Crisis Hotline

+1 (800) 996-6228 Family Violence Helpline

+1 (800) 784-2433 National Hopeline Network

+1 (800) 366-8288 Self-Harm Hotline

+1 (800) 222-1222 American Association of Poison Control Centers

+1 (800) 622-2255 Alcoholism & Drug Dependency Hope Line

+1 (800) 233-4357 National Crisis Line, Anorexia, and Bulimia

+1 (888) 843-4564 LGBT Hotline

+1 (800) 221-7044 AIDS Crisis Line

+1 (877) 565-8860 The Trans Lifeline

+1 (800) 273-8255 Veterans Crisis Line

These phone numbers were pulled from the following resource which is US-centric but you can call from anywhere if you need the help:
https://www.caredash.com/articles/which-online-therapy-servi...
No joke, this would get a fix published very quickly. I’m embarrassed I didn’t think of it myself.
Also depends on who you ask. I know lots of people who consider stripe more attractive than Google.
Full disk encryption?
Coronavirus: Will our day-to-day ever be the same?
If your investment horizon is longer then your life time, then it means it's dynastic wealth, and is passed to your children/kin.
Probably not underestimated, but I suspect that in 5 - 10 years time we'll start to witness XR becoming everyday tech in our lives.
Code requires 20amp circuits in the kitchen (and garage). However it allows 15amp outlets so long as you can pass the full 20amps through, which all do.

Or did you mean. 230 volts?. Every time I accidentally come in contact with mains (only twice in my life, but that is more than enough) I'm glad we are lower, and wish it was less.
This is inconsistent - microsoft is arguably many times worse than apple in regard to telemetry and things like forced updates.
This resonates with me far, far more than most, if not all, articles, essays, think pieces, etc, about getting things done and procrastination I've ever read. Indeed, I have a serious problem with wanting to have something be perfect when I do it, so often I don't feel like doing it. Ironically, that attitude has the result of sometimes making my work worse, since ultimately I end up having less time to do the work which can lead to sloppy results.

I'll now have that nitpicky attitude in check and remind myself that not completely perfect merge/pull requests are still work that my clients can see, and the feedback loop within them when they're not perfect from the get go doesn't necessarily have a downside, and can in fact improve communication and the flow of work. After all, a request is by definition not necessarily the work completed, but literally a request for feedback, and possibly iterating on the work already done.

I can even use a trick to mentally tell myself it doesn't have to be perfect: I can start work everyday with the expectation that, at the end, I only need to create or update a draft merge/pull request. That will get me even more easily into the mindset that I'm working to ask for feedback, not to deliver the final piece. Who knows, maybe by the end of the day the work will be good enough for a finished request, so it's a win-win situation.

And that's just one idea, that I need to put in action. I'll see how it goes.
It's not only lofty and "maybe" attainable, it's already happened, beginning decades ago.

That is a very rose-colored glasses viewpoint. WW2 ended only 80 years ago, which is a minuscule amount of time in the grand scheme of things.

And since that time we haven't had a global conflict, but add up all the proxy wars, civil wars, "low intensity conflicts" and we're still looking at millions of dead.

I'd argue that the reason why we haven't seen a major global conflict is just the immediate post-WW2 global order (2 major superpowers with nuclear weapons) which drove it to multiple smaller conflict. Depending on how the world order changes (i.e. China) there is nothing to say we won't see another major global conflict.

And yes, organizations like the UN are great ways to address conflict before they become major wars, but I'd argue the effect has been incredibly small. The UN existed at the same time as the Vietnam War, the Afghanistan War, the Rwandan genocide, both Gulf Wars and it was basically "the UN issued a strongly worded statement" and the wars happened anyways.
By successful you probably mean in the monetary sense. I think it's easy when you choose that as your goal. Not everyone strives for that. Especially software engineers who have enough where it sometimes already feels like excess and going after more becomes less attractive.
Super soldiers? Were that the issue, we could take LeBron James, Brian Shaw, or any number of intelligent athletes with various advantages and ask for sperm samples. You could have a couple thousand kids to mold from birth.

It turns out, as a society we haven't done that already, and neither has any other society. Conceptually, it's interesting to think an adult could have their genetics changed, but we have cheaper ways and we haven't even exploited those.
Because in the US, it is more and more common to run everything on 14ga wire. It’s just cheaper to run low end plugs most places.

OTOH, in my workshop, I just got done running a 60A circuit at 220v for a welder. I wish I could have the same for a kettle.
> 1) just confirm that there are mechanisms by which he could have be not allowed to check in the code

If that's what you read out of the post, when I literally said the opposite, I can't reason with you.
In the Vault 7 leaks, Little Snitch was mentioned as something three letter people had problems with circumventing. I think it's worth considering whether this new attack surface is there by design:

https://blog.obdev.at/little-snitch-on-vault-7/
5 hours ago I read an article posted here on HN regarding new innovations using this tech.

https://news.ycombinator.com/item?id=25094297

I am aware the article did briefly touch on this subject but still worth a mention here, considering the subject.
Why _should_ you have to disable this feature? Sigh.

My point: opting out should be much, much easier.
I can't speak for the book, but I was a participant in a mindfulness study a decade ago. The biggest thing about it, I've taken, is that you recognize your feelings and acknowledge how they are causing you to behave. It doesn't transform you into an emotionless monk, but rather aims to make you aware (or mindful) of how you and your actions are being motivated through your emotions and non-awareness. For example, a mindfulness-driven diet would place emphasis on cultivating awareness of mindless snacking and aim to make you aware that you don't actually need to be eating at the moment - you are just snacking out of boredom or instinct.

With regard to emotion, like I said, mindfulness isn't meant to eliminate emotions, or even eliminate negative emotions. If something makes you mad or angry, you may carry that emotion into later tasks. Mindfulness is about recognizing the anger, acknowledging it, but understanding not to project onto other things.

There's probably more to it, but I was trained in mindfulness by proxy of martial arts (that was the study) [1]. I never studied it outright and only took a Mindfulness Attention Awareness Scale survey a few times over a few years. The paper I linked might give you some ideas on what mindfulness is.

[1] https://journals.sagepub.com/doi/pdf/10.2466/22.23.PMS.116.1...
check out the similar overpass font on linux.
ugh/ I appreciate the article, but I could not have gone to Harvard and could have told you that. It ain't that hard.
XR?
Question to HN folks: how valuable is it to have FAANG on your resume?
Or stop buying stuff that is broken-by-design in the first place.
Are you suggesting paneer is neither cheese nor milk? (exploding-head-emoji)
I don’t have any information on their tracking methods, but strawpoll.me has been around for years and is relatively popular for polls.
I would be careful in extrapolating what works for pizza to other types of foods. AFAIK, pizza is very profitable and those margins can subsidize delivery drivers.
As high as those fees might be, you have to look at the total cost of operation for the service.
what if everyone uses it (or other genetic treatments) for augmentation or design? there is a critical mass when compulsory loses its meaning, I think. you don't have to eliminate cash by law for example if no business will take it.
When my wife uses this line of reasoning I point out that she's taking solace in other people's pain. It's kind of a joke, but it's also kind of true. Don't need to minimize your own suffering just because someone else suffered more.
Yeah, because encrypted data should be incompressible, as it should be indistinguishable from random data, which is also incompressible.

Reality is a little different of course, and compression can cause problems for encryption because compressed data tends to be highly predictable (especially things like compression headers and compression dictionaries). This allows for potential “known/chosen plaintext” attacks on the encryption.

Some classic examples of this type of attack are breaking Enigma (known plaintext, no compression) by assuming the content of some messages[0] and the more recent CRIME[1] attacks against TLS using compression to help produce a chosen plaintext.

The simple solution in these scenarios is to avoid using compression completely.

[0] https://www.quora.com/Did-the-inclusion-of-Heil-Hitler-at-th...
[1] https://en.m.wikipedia.org/wiki/CRIME
I feel this way as well. I have moments of being stuck in my house with my great family and say “man I’m tired of the pandemic” or “my kids are acting crazy”. Then I remember the lives of others, not just men who were drafted in the wars but their wives who had to make a living and raise their children in a time that it wasn’t so easy for them. I also think of other countries where people aren’t stuck in a house but a shack with 5 others and have to go out and do dangerous work.
Not invalidating that there are people with depression that I could never understand. I also realize some people are very alone and don’t understand why. BUT if your biggest problem is that you are stuck in your house or apartment over in Silicon Valley or NYC playing video games or reading books, I have a hard time being sympathetic. Things could be much much worse.
Lightfield videos, and more decentralised services, like funkwhale is for music, but for email, chat, social networks etc.
Missed opportunity to call it "Racebook"
Hummingbird in SGS2 (this was before rename to Exynos) and A4 in iPhone 4 stem from cooperation between Samsung and Apple (who previously used Samsung SoC in iPhone 3G and I think in 2G). The teams split before both phones reached maturity in design. From then on Samsung kept iterating on the Hummingbird design till I think quite recently - I'm not sure if my Note 10+ doesn't still have cores derived from that design.
OCSP responses are signed, so no, that doesn't work.
> or the whole credit card payment ritual

Huh?
I'll also add a suggestion for Martin Seligman's "Learned Optimism" [0]. A mindfulness practice on self-talk (along with giving up sugar and reducing carbs) has made a huge difference on managing my mental health.

[0] https://en.wikipedia.org/wiki/Learned_optimism#Seligman's_me...
My native language is not English, so I cannot recommend cooking book in English.

Cooking in microwave is really simple, when you understand how to regulate cooking temperature with water, and how much time and power you need to cook meal.

Example recipe: put into a dish cup of water, half cup of rice, slice of chicken at top. Cook for about 20 minutes at 600W, or (easier) cook at 900W for 5m, to boil water, then continue to cook at about 40% for about 18m. If it undercooked: warm it again and keep warm for some time. If it overcooked or boiled out: next time add more water or/and reduce cooking time and/or power. At the end, add butter, vegetables, salt, etc. To keep the meal warm at low power and to avoid excessive drying at high power, cover the dish with another dish.

Similar recipe here: https://steamykitchen.com/22048-how-to-cook-rice-microwave.h...
A big part of the problem is that the data was sent, even when mobile data was turned off.

If you were traveling abroad, there’s a good chance you’d get screwed with International Data fees.

This is as bad as when Apple tried to keep Bluetooth on when you turned it “off.”
If China decides to take Taiwan by force, there is very little the rest of the world can do to stop them.
Large volumes of minerals that are already in space (don't need to expend energy putting them in orbit) to build settlements, ships, etc...
Never understood why such companies aren't cooperatives.
This is similar to me. I prefer to eat vegan, but won't be absolutist about it when i'm eating out or if someone gives me food for free. Now i describe my diet as "aspirationally vegan".
How I read [in Clusters]
fetuses with down's syndrome are routinely aborted.
I once about 23 years ago was invited over a girlfriends mom for a roast beef dinner. I watched her put the roast in a microwave and blast it. I was in shock but didn’t say anything. She used the oven and did up some Yorkshire puddings quickly and already had some mashed potatoes. Next thing I know dinner is done. I was certain leather was being served. But to my utter surprise the roast was cooked perfectly medium rare and was to this day the second best piece of meat I have tasted. I don’t have the guts to take a $23 piece of meat and risk trying it myself.
The rise of randomized controlled trials (RCTs) in international development [pdf]