skysight-inc/HackerNews huggingface dataset:
Yeah this objection is a red herring. You need to look at the effect size.

If you have found a protocol where (according to the study author) "the magnitude of the effect we saw was about four times larger than what clinical trials have shown for traditional antidepressants on the market", if it's just a placebo, that sounds like a great placebo to be giving!

As noted above I seriously doubt the concept of a placebo is even well-formed for psychedelics.

I quite like Scott Alexander's take on this issue:

> Actual carefully-researched psychiatric drugs are exquisitely selected for having few side effects. The goal is something like an SSRI – mild stomach discomfort, some problems having sex, but overall you can be on them forever and barely notice their existence. In the grand scheme of things their side effects are tiny – in most placebo-controlled studies, people have a really hard time telling whether they’re in the experimental or the placebo group.

> Nobody has a hard time telling whether they’re in the experimental or placebo group of a trial of high-dose MDMA. I think this might be the difference. If you go for large effects – even if you don’t really care what direction the effect is in – you’ll get them. And if you go for small, barely perceptible effects, then you’ll get those too.

https://slatestarcodex.com/2017/06/05/is-pharma-research-wor...

Also see https://slatestarcodex.com/2018/01/31/powerless-placebos/

> All three looked at studies comparing a real drug, a placebo drug, and no drug (by the third, over 200 such studies) – and, in general, found little benefit of the placebo drug over no drug at all. There were some possible minor placebo effects in a few isolated conditions – mostly pain – but overall H&G concluded that the placebo effect was clinically insignificant.

> What happened? Probably placebo effects rode on the coattails of a more important issue, regression to the mean. That is, most sick people get better eventually. This is true both for diseases like colds that naturally go away, and for diseases like depression that come in episodes which remit for a few months or years until the next relapse.
So the question I wonder.... did humans give the mink the bug, it evolved in them, and now it’s reinfected the humans.

Really bummed I live in a world with gain of function research... this awful bio-weapon has really gotten out of hand.
Ask HN: Are there any efforts to make our species more peaceful?
Often I think that having shared goals as a species would be an ideal trajectory.

It seems but a pipe dream when I observe the division, polarisation and greed among us (myself included).

Are there any formalised efforts to leverage our unprecedented connectivity with an eye to mass cooperation to achieve shared goals among humankind?

Or even pursuits to fix the very worst traits of our species?

Sorry if this question is a bit vague, or idealistic.

Kind regards
Bugger me, that describes the process I (not a PhD) have gone through trying to digest some papers so well it is eerie.

I've been damned lucky. The worst paper, the one were I had to read most of the citations and quite a few of their citations before I got it was http://conferences.sigcomm.org/sigcomm/1997/papers/p011.ps and yes it took over a month before all the pieces settled into the right corners of my mind. Perhaps more accurately, it took months for my mind to create the right corners for the concepts to settle into.

But that was fine - I knew before I started it was the seminal paper on the subject, and so it would be worth whatever effort it took. The idea of wasting that inordinate amount of time going down that path with one dud after another makes me shudder in horror.
If anything, I would say fur gets a disproportionately high amount of attention from animal rights activists, relative to the total number of animals affected. According to Animal Charity Evaluators, an effective altruism group that focuses on animal welfare [0]:

> Of domesticated land animals used and killed by humans in the United States, over 99.6% are farmed land animals, about 0.2% are animals used in laboratories, 0.07% are used for clothing, and 0.03% are killed in companion animal shelters.

I am assuming they are grouping animals farmed for fur in the ‘raised for clothing’ category.

[0] https://animalcharityevaluators.org/donation-advice/why-farm...
We never needed electronic voting to prevent the hanging chad issue. All we needed to do was help people properly encode their paper ballots.

That can be done with open source software running on a PC connected to a punch card machine.

We could also let voters confirm their choices with a punch card reader hooked up to another PC running separately developed software at the polling place.

You can still the votes electronically. But also count the physical ballots. Two counts are better than one. Somebody woould have to change both to hide cheating.

Record the raw ballot in a block at the same time to make it even harder.

These are solvable problems. If we can keep cryptocurrency honest, we can do it with votes.
Yeah. I only caught a few comments from him and then when I started go ogling it, he's actually pretty big both in funding this work and in fund raising and raising the profile of it. He had (has?) pretty bad depression so...
I definitely see the point here, but it depends on what you mean by “understand”. I don’t think that understanding blockchain or the technical components of how such a system works would be important to the average voter.

If such a system could improve the visibility and auditability of results down to small regions, and intuitively show how that cascades up to state level results, it could be a win.

Making an e-voting system believable seems more like a UX/design challenge than a technical/engineering challenge.
> I tried to create a table called `test`, but I got `something went wrong but we won't say what`

That means it got an error while running git.
The simplest is probably to make a deal with criminals that have an existing money laundering network. The trick would be avoiding having said criminals simply kidnapping you and forcing you to reveal the keys.

Low volume ways would be to use the bitcoin to purchase drugs or other illegal goods by the kilo and sell the drugs the usual way.

It's unlikely that the person needs to full billion immediately. Five or ten million a year could be enough for many people and at that kind of level exchanging for monero could work.

There is also the option of sending small amounts to thousands of real people's bitcoin wallets (and lots more to wallets you control) and letting those people deal with the FBI first.
I had no idea there were two cuts. Pizza Hut is a good choice too :)
You don't understand the difference between hosting hate-speech and hosting people who host hate-speech. Seems pretty clear-cut to me.
How about the combination of the drug and the experience is the treatment? In that case the placebo is telling someone with depression to sign up and stay at home. Which is still important.
This isn’t a “lack of information security”, the whole point of transponders is the broadcast your aircraft identity and position.

Having to coordinate with every ATC jurisdiction along a flight path would be extra work and leave room for errors.

Additionally it wouldn’t work for flights that don’t have a planned route, like a civil aviation pilot who’s just cruising.

It’s akin to having a license plate on your car.
In the same sense that Intel enabled/pushed a low volume Cannon Lake laptop as a China only SKU so they could tell the analysts, "see we've shipped 10nm" - even if the onboard GPU didn't work and had to have AMD RX540 instead.
My domain is much less rigorous than banking, and even here, account closures are beyond discussion. The humans in the loop are low-wage, low-autonomy workers bound by detailed SOPs that have been lawyered to death. Owners of closed accounts sometimes sue, and the program's determinism / consistency are valuable defenses. So even if the process does something obviously wrong in the eyes of the senior people looking at it, as long as the process is correctly applied, they are very hesitant to make exceptions.

My guess is that the people he worked with were genuinely positive and grateful, but then his account got caught in a machine like this and they were powerless to stop it.
> not to mention Walmart probably has the buying power to insist their suppliers pre-tag all items.

That wouldn't stop them from paying for the tagging. If it happens at all, everyone later in the supply chain has to pay for it.
Is it bold? If a group of people put something together and release the details for free, they have to expect others will profit off of it. This is the fate of all useful open source software that doesn't have some kind of no-commercial clause (which potentially moves it outside the ideals of open source as it restricts the use of the source code).
San Francisco has an area (Upper Haight) where a lot of the gutter punks live and hang out. Stanley Roberts (former KRON 4 reporter) did a brief story on them. He found a majority of them in their 20s were from out of state and came to SF because of our lax drug enforcement laws. They said where they were from (most from Midwest) came to get away from the strict drug laws.

So it’s possible more drug users will move to Portland for refuge.
Huxley in Brave New World came closest to describing modern day depression. It's a lack of meaning. So many people these days believe the entire existence of the human race was an accident, so of course many people will feel their existence is meaningless and doesn't matter and of course that will depress them. Pumping them full of soma doesn't change that fact for these people.
Agree with you in part that all professional programmers should be comfortable coding most things with out GC and not see it as obscure scary stuff but the in startup world there is no much "pays off in the long run" thinking, it's ship whatever is the fastest to build now over great software.
> But the guy in question here did something really dumb, was very lucky, and should stfu.

Your comment started out reasonable, wandered around, and then veered into outright malice.

As others pointed out, the OP had permission from the bank to carry out an investigation. From his telling, he did not, at any point, steal money.
Fix the source of the problem.

I imagine this drug can uncover the problem and help the person solve it.
> Tor and end-to-end encryption recently made their public shit list

I think I missed this news. Can you please elaborate?
Again, I'm mostly coming from embedded systems. I can guarantee you that at least LISP and APL would be totally unsuitable there. They are very much not the languages to model on.

Pascal was usable in embedded systems. It was used, even. But compared to C, it was like picking your nose with boxing gloves on. No, in my world at least, you don't want a "slightly higher semantic level". C got it far closer to right than any of the others, even Pascal.
To be clear, the claim isn't that other communities never discuss academic concerns, but that they are also interested in the practical aspects of building software products while OCaml is (more or less) singularly focused on the academic aspects.

Yes, the Rust community is interested in the academic aspects of eliminating classes of errors, but it's also very interested in addressing pragmatic problems. Consider all of the sites for Are We (Web | GameDev | IDE | etc) Yet as well as the remarkable progress they've made in such a short time. Rust's entire history fits in the amount of time that OCaml has been struggling to solve parallelism.

> Jane Street has built a multi-billion dollar company using this approach. If you view such as "abstract language design", then your loss.

That's really great for Jane Street, but it's really not the badge of honor you (and the rest of the OCaml community) think it is that a single company has managed to muster some success with your preferred language in its 25 year history. It also doesn't do much to illustrate that the OCaml community is broadly interested in practical matters--only that one community has done, and they have done a lot of work to make OCaml manageable (like Google has done with Go, except that Go enjoys marketshare outside of Google).
The problem with that theory comes when people who have all of that and more get depressed. I do think you have a point in that the cause can be external but I think to see it as social is far too limited. Then there are cases where it's entirely internal as well, depression being a symptom of various illnesses. I'm not sure if you know this but a lot of theraputic work does focus on solving external problems. You might also observe that there can be quite a catch-22 effect or bootstrapping problem here as well.
>That should only be done when you reach large scale, at which point people have leveraged other AWS synergies making it harder to exit the platform.

And then you're bleeding money!
Thank you.

I've had a very bad experience w/anesthesia so am always nervous while dealing with anything of that nature. Wonder if that predisposes me to a bad trip.

Not sure that would be worth it for just 2 weeks of relief.

Also not sure I'd be able to find any such doctor near me. Probably health care providers are much more open minded out West than it is here.
It its pure psilocybin, I'd imagine show. If it was mushrooms, that's not even a micro dose from what I understand.
Is it an insinuation when the user themselves has stated, on multiple occasions, that this exactly the case?
What behavior of mine do you think I should change? I didn't see any suggestion of something I actually did wrong. It felt like you were trying to criticize, but that your criticism had no actual content.
# Model of Small Decisions
## Re: Try to avoid multitasking
As a fullstack developer I find this particularly apt. I'm most productive when I deliberately focus on one part of the stack at a time (think days, not hours) and I rely heavily on the notes that I take to provide context.

## Re: Remembering effective rules
When I'm documenting, often I'm in the mindset of, "I solved this problem today, and writing it down ensures that I won't have to re-solve it next month"

## Re: Minimizing decisions
My most productive days revolve around making decisions up-front, ie planning out the steps of a project in a Kanban or bullet journal at a granularity of 30 min chunks (~15 min expected time, 15 min slack)

# Possibly Related Work
## Readme Driven Development
https://tom.preston-werner.com/2010/08/23/readme-driven-deve...
The idea is to write your readme before you start coding. Just enough upfront planning to imagine what the system will be, discuss with team, and make changes, while delaying making all the small decisions that are needed to actually bring it to life.

I think that RDD is an admission that small decisions exist, so we should try to make the best big decisions that we can up-front while the cost of change is lowest. Each of the small decisions that you make in coding adds friction to change.

## Basecamp Hill metaphor
https://basecamp.com/features/hill-charts
"The idea: work is like a hill
Every piece of work has two phases. First there’s an uphill phase where you figure out your approach. You have a basic idea about the task, but you haven’t figured out what the solution is going to look like or how to solve all the unknowns.

Eventually you reach a point where there aren’t any more unsolved problems. That’s like standing at the top of the hill. You can see clearly all the way down the other side. Then the downhill phase is just about execution."

This too I feel is an admission that small decisions exist. It's an understanding that even when you have a plan, projects go through a phase in the beginning where there's a concentration of decisions that need to be made, and each of those decisions introduce some measure of uncertainty.
What you say does happen, and it's an interesting perspective (I guess I had always seen the "half-baked history" sections as something annoying but inevitable). Pick your poison, I guess.

And the answer is that in general, we do write (short) histories for each paper, unless maybe in short conference papers (limited to 4 pages or so) while it's OK not to write any.
There was a clear winner on election night: Marijuana
Exactly. The market for GPUs using 75W should get interesting soon.
"Depression" is a bit of an overloaded term.

Maybe the easiest way to think of it is an electrochemical circumstance in the brain. This circumstance could come about as a result of external stimuli (or lack thereof), or through some imbalance or other more internal issue. I think the technical terms are something like situational depression vs clinical depression.

Even with situational depression, a fresh perspective can often give people the bit of confidence and hope that they need to proactively break depressive cycles.
How so? People love cheap shit without paying for the externalities.
I'm watching the US election from the outside, and the President declared a win, said the Democrats were trying to steal the election and he is going to the supreme court to stop voting. Twitter is packed with people apparently saying that it's impossible for PA to swing from Trump to Biden just by counting the postal votes, or that counting postal votes after the polls close is cheating, or that the postal votes were made up, or that the polling station votes are untrustworthy because there's no need to prove ID, or that polling stations were closed, or that the whole system is illegitimate if voting is not a public holiday, or not mandatory, or not proportional representation and no electoral college.

Again, whichever outcome, USA is going to have half a country that doesn't like or trust the election results. Not the voting booth ones, not the mail-in ones, not the popular vote, not the official result or the "official" result.

Seems to me that if people trust the leadership, they would trust the voting system endorsed by the leadership, not the other way round.
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Yes, it does go against prevailing wisdom to think that the only cure to depression is other people; it's generally considered that (at least part of) cases of clinical depression can not be solved solely by psychological or social means as they involve problems with, so to say, literal brain chemistry; social and emotional connections with other people are helpful to manage symptoms and assist recovery but they aren't sufficient to fix the underlying cause. And also for psychological problems which can be helped with non-drug therapy such as CBT and the likes, "other people" are again a helpful, perhaps necessary, but not a sufficient factor, they don't replace actual treatment.

In general, the boundaries of what people call "depression" is very fuzzy and usually far wider than what doctors would call "depression". I can certainly agree that there are a lot of "what-people-call-depression" cases which could in fact be helped by a change of company and habits and literally connecting more with other people. But there are also a lot of people for whom suggesting "connect more with people" is the literal equivalent of telling a person with broken legs to "walk more", as their current ability to connect with people in a functional and rewarding way is simply not working properly right now. Unhappiness is not depression; depression can involve things like feeling subjectively unhappy or even suicidally miserable during experiences that the depressed person agrees are really rewarding and positive, it's just that their happiness/reward system is broken currently.
Doesn't that still allow for vote-selling and vote extortion? Like if my employer threatens to fire me unless I vote a certain way, they'll accept me giving them my receipt saying I voted the way they wanted. Now, they can't prove that the receipt actually belonged to me, but it's certainly harder to procure someone else's receipt (from someone who voted the way the employer wanted).
That's entirely due to TEDxSyndey having poor lighting that cast a shadow on his face.
What prints better at this price range though? It's the cheapest full duplex WiFi laser you can buy.
Will it force RabbitMQ to also change its open source license model like Redis ?
No workable suggestions on moving forward and how to do better, no attempts to make it up to Jeremy, but copious amounts of self-flagellation. Does anyone else find this thoroughly unacceptable?
I am very interested in "workflowy offline" for Desktop. I'm unable to use Workflowy at work at all because it syncs everything to the cloud. Just an FYI.
good rec
I have had treatment-resistant major depression for eight years. During that time I have had long periods with extensive, frequent social interaction and bonding. My depression encompasses most of the time I've known my now-wife, repairing a broken relationship with my father, the acquisition of one new close friend, and the coming and going of many transient relationships.

I don't know what the cure for my own case of depression is, and I'm sure if I were isolated/disconnected my condition would be worse, but the evidence available to me indicates that simply connecting with people is not what's going to fix me.

My wife and mother-in-law are both counselors, and routinely successfully treat people with depression. They have never indicated that level of social connection is either a dominant cause or reliable treatment for depression.

If you want something to read up on, a very popular treatment methodology for depression is CBT (Cognitive Behavioral Therapy). The premise is that depression is often caused by harmful thought patterns about yourself or your life, and CBT trains you to arrest those thoughts and replace them with thoughts that are constructive or more accurate (less exaggerated, etc.). It's not the treatment I need, but it works for an awful lot of people, and its solution isn't built around social connections (though it may reveal social connections as a problem in individual cases).
UT Austin researchers develop self-watering soil
Unfortunate it’s limited to cars
Loss of interest in learning new things is a sign of aging.
nvm I figured out a solution
it's back!
The problem in my opinion is that not everybody counts as the people who can help you get better. Your social needs could be related to an idealised image of yourself that you can't achieve, a desired romantic relationship, a sense of being part of a group around your age, etc. It's entirely possible that you never meet those expectations due to your specific circumstances, which makes any effort to connect with people a failure.
nuclear asteroids <grin>

Put into stable orbit around the Sun both gets it away from Earth and also available if in 800 years we find a good use for it to be recycled. If, on the other hand, there's never a recycling use found for it, it can safely decay for a few thousand years till it's harmless.

It's probably cheaper overall to put it into stable solar orbit than trying to dispose of it safely on Earth. And a stable orbit means that it's location can be accurately determined for thousands of years. Possibly even specifically locating "Nuclear power waste in this sector, medical nuclear waste in that sector, excess plutonium in that sector, ..." etc.

To day's deserts may be tomorrow's urban areas. Imagine how much it would cost to safely clean up a huge area that's been contaminated by nuclear waste.

(There's plenty of evidence of the cost of cleaning up old nuclear test sites. https://www.nytimes.com/1990/07/04/us/cost-of-cleanup-at-nuc...)

Back when the world wanted kerosene for lamps, the 'rubbish' petrol/gasoline was discarded for many years. That petrol would be very valuable today, but it's been lost.
I put "Benchmarks" in quotes because its about how much code it takes to complete each GUI task with a given GUI library, not speed of the application itself.