skysight-inc/HackerNews huggingface dataset:
Best thing anyone can do is to familiarise themselves with what they take, and what the key indications are with mixing medication and what happens when you stop. In NZ we have medsafe (https://www.medsafe.govt.nz/), a govt website that lists everything they give out. There's also the The New Zealand Formulary (http://nzformulary.org/)

An example here is that too many doctors believe that Pregabalin has no withdrawals. They're very wrong. Here, they will prescribe it for anything. It works really well too, but there's a lot of hidden bullshit. As an example, they give it to people with epilepsy, but one of the main contradictions is that it can actually cause seizures. So when that started happening for me, they put me on clonazepam (2mg, six times a day).

When I burned myself, I told the hospital I did not want either medicine. There's no point in taking Pregabalin if I have to take so much clonazepam to fix the side effects.

A week later (while still in hospital) I had a panicked pharmacist for the ward visit me and he's like "omg we weren't giving you these two" and I said, "nah mate, it's fine. I feel okay apart from the pain" and he's like, "hang on, you just stopped 12mg of clonazepam a day and you feel fine?" and so I said yes, it's because it simply stopped working and my body has decided it doesn't work on me anymore, which is why I can't take the Pregabalin either... and the stupid thing is the Pregabalin is probably one of the best things I could take right now due to it's amazing nerve pain relief. I'd rather not have seizures though, nor have to find the right kind of benzo to help. I doubt I'd find one that's different enough from the rest to help.
There are multiple points in the article we are discussing that touch on how restaurants are pivoting how they serve dishes in order to keep them warm.
Haha. Just made a change actually. I was chasing money and realized it's not worth it if you hate the rest of your life.
I'm working on a book that focuses on Ansible, Terraform, Packer and GitLab (CI) and their integration. I'll eventually incorporate Docker and K8s too (just built a physical cluster at my office for giggles.)

I believe you're correct in that this is a fine stack of tools that can get anything done. I wish businesses would just use them.
Citizens United had to do with independent expenditures on "electioneering communications", defined as advocacy related to specific political candidates. Spending on issue advocacy was already unlimited. (Which is almost certainly the right decision - if issue advocacy were restricted, organizations like the EFF wouldn't be able to talk at all in the 60 days before an election.)
TL;DR: I think it is reasonable to blame Purdue for the reduced access to opioids we are now stuck with.

Purdue caused more addiction to occur, which in turn caused reduced access to the opioids that existed prior to the creation of Purdue's nuisance product.

Also, perverse incentives caused by the patent and licensing system motivated them to make OxyContin unnecessarily addictive in it's formulation and dosing schedule, in order to engage in patent "ever-greening" of an existing substance.

Oxycodone has been around for a long time, but was doesed and administered more safely in older products.

Purdue did some pretty perverse things to support their patent and regulatory rationale for OxyContin. To gain approval as a superior and patent-able alternative to the other extant gerneric hydrocodone and oxycodone products, it was claimed to require less frequent (but larger) doses. The result was that large numbers patients found that when taken as directed it provided superior pain relief, followed by a return of pain, in conjunction with hours of opioid withdrawals until the next dose. Early on in the product's life cycle doctors were encouraged to increase the dose but not the dosing schedule when patients complained, in part because the alternative would have undermined the rationale for the existence of the product.

Although this was probably an undesired side effect from the point of view of Purdue, they could hardly have designed a better way to cause drug addiction. Millions of people took this product and many became addicted. Purdue went far out of their way to publicize people as criminals rather than address the fundamental problem with the way the product was administered. It seems to be evidenced that the more effective administration schedules of other already existing products cause less addiction, so at the margin, Purdue caused many more drug addicts to exists than would have otherwise.

If they had not done this, or had been willing to adequately address the problems, we would probably still have easier access now to the opioids that already existed. The problem has grown to such a scale that it is now very hard to "put the genie back in the bottle."
Dropbox was and is an obvious niche that just comes down to execution.

“Temporary Unicorn” is a valuation in the billions without profit to back that up. Tesla for example could still fail, but it’s made 100+M in profit for multiple quarters which seems like a safe objective benchmark.
3Blue1Brown is really great for learning/refreshing math. He has great visualizations.

I especially enjoyed this video (not exactly a math tutorial more of a cool explanation): https://www.youtube.com/watch?v=OkmNXy7er84
> During those three weeks, Emirates had five flights with seven or more infected passengers on each flight, for a total of 58 coronavirus-positive passengers flying on eight-hour trips. And yet, nobody else on the planes — none of the other 1,500 to 2,000 passengers — picked up the virus, Freedman and his colleague report in the Journal of Travel Medicine.

That's amazing. Though, importantly:

> Planes have excellent air ventilation and filtration systems, which remove coronavirus particles from the air about every six minutes, the U.S. Transportation Command reported Thursday.
Joint probability of independent events, especially the common case of independent, identically distributed data. (Or exchangeable observations, in the Bayesian framework).

For example, flipping a coin n times, observing heights of people in a population, etc.
Hadn't heard much about this guy before, real smart cookie! Amazing to think of him building and operating that 'Tubeless aerial telescope' back in 1684, 336 years ago!

Such a hackery-stance on accepting new knowledge too, and this (one of his critics):

"Many thinkers, such as the English clergyman Joseph Glanvill, saw the acceptance of things not known for sure as the thin end of a wedge that would prise open a world of atheism."

Quite an insight!
From what I can see online the Turkish and USD prices are quite similar?
They try to detect Virtual Machines. I don't know how easy it is to spoof since obviously I wasn't going to try it.
What’s the comparison between a-Shell and iSH? I’ve somehow never heard of the former, but I have repeatedly heard about the latter and used it.
not sure but I had just listened to the podcast recently that talked about it's origin in relation to 8chan, really interesting stuff. Fredrick Brennan started 8chan and basically discloses who he thinks started 8chan.

posted to sqwok https://sqwok.im/p/RIKGD2izBgP7SQ
The crowdsourcing campaign mentioned in the article: https://ca.gofundme.com/f/stand-against-proctorio
They need to load balance them so the world can have HA soft-serve. Run them in a Kubernetes cluster.
For the record, I also have expressed plenty of choice words for both Google and Chrome, too.

I think the whole web is garbage and I'm prepared to throw it out. That's the point I'm getting at here. I don't see Mozilla as the last holdouts of a system which is true and good before the flood of Google overtakes everything and ruins the good thing. I see Mozilla as already drowning in that flood and the "good thing" as being not good, but abhorrent.

Maybe they could have held the tide, but instead they stuck their fingers in every fad they could reach, and got burned, and now they're neck deep in problems of their own making. And I don't think it'd be better if they were ankle deep anyway.
OxyContin/oxycodone (30mg tablet)

2002 8.8 million pills

2011 781.5 million pills

The US didn't experience a massive increase of numbers of people in pain.
Did doctors not prescribe opioids for pain management before the Sacklers? My understanding was that they did but were hesitant, which considering the nature of opioids seems entirely reasonable.

When I had routine surgery a few years back the doctor insisted I take a prescription for Oxy, even though I told him I was fine. I filled it at his insistence and within a couple days could feel my body building dependence and craving more. I switched to ibuprofen as it freaked me out to feel how strong it was. It seemed very irresponsible to prescribe Oxy for something as mild as my case.

For debilitating chronic pain? For sure, these need to available. If anything Purdue pharma made this situation worse for those that actually need these drugs.
From your link:

"including prescription pain relievers, heroin, and synthetic opioids such as fentanyl"

So recreational drug abusers are included in the count? I believe the OP was only taking prescription drugs.

Is there a count somewhere of just the overdoses on prescribed opioids?
Because 80% of people unsubscribed after a three month trial on a mobile phone!

That is hilarious! The whole business plan is making that difficult and people forgetting and still! ahahaha

This onion article writes itself.
Theranos would be a great example of a "temporary unicorn": it peaked at over a $1 billion before its fraud was discovered.
> Quibi was more "I'm going to spend $2Bn failing where others failed before"

This is what makes it especially ridiculous. Verizon had just failed with a huge splashy launch for go90. It takes a ton of arrogance to then decide to do the same without any real innovation. Rotating between landscape and portrait is a feature not an entire product. And especially not the basis for a media company.

The average startup founder would never be in the position to pitch an idea like this AND still receive $2B in funding. This wasn't just a bad bet it was a stupid one.
Do companies you've worked for in the past normally approach you about promotions?

Maybe it's because I'm shy or bad at self-promotion, but I've never had an employer offer a promotion. Even after getting great performance reviews, I've had to fight tooth and nail or go through a promotion committee song and dance that can drag on for months or years.
> I was wrong. In fact, a lot of merchants saw the third-party domain as a status thing.

An argument against custom domains being a "premium" feature, then? If you don't have a paid plan, then you have to bring your own domain. Paying gets you the *.example.com status symbol. Makes sense — a custom domain usually requires technical expertise and some amount of inconvenience for users (not unlike a services company that publishes their source code to GitHub, which you can always set up and maintain for yourself, but if you want to use the company's hosted services, then you have to pay). Another part of the value proposition would be, "You're gonna have to spend money one way or another — either to a registrar or to us — so why not let it be us?"
In my reading of that text I note two things

1) Whewell is not coining the term, but claiming it was proposed by "some ingenious gentleman" during previous (1833 meeting?) discussion - was this perhaps sarcastic self-reference? More importantly he suggests it was discarded at the time.

2) More broadly while this comes up in the discussion of what exactly they should call what we now refer to as scientists, it is as an aside in discussion of Mary Somerville's work.

It seems then that the term was neither coined by Whewell, nor was it coined directly after Mary Somerville. Rather it was (first?) recorded in use here by Whewell, picked up again in explict discussion of Somerville as an exemplar.

If correct I guess this makes most arguments here sort-of right, unless there is an earlier written source?
Because the doctors were lied to by Big Pharma. they advertised Oxycontin to doctors as a drug that would not create addiction and claimed that is was safe to prescribe in large doses and for ongoing treatment.
>I feel like a lot of people laughing are just expressing the feeling that they could do much more if they were given 1% of the investment Quibi had.

this is 100% it. if this were some scrappy startup who had fought to launch a product and failed, i could respect that. but it's a couple old rich people who raised $2B off their names and reputations, and then squandered it in record time by overpaying for bad content.
But we're talking about "continuous variables", random variables with infinite support for which P(X=a)=0, for all a.

It's kind of like just a single point in the convolution for "X_1 - X_2", corresponding to "X_1 - X_2 = 0" ?
IMHO, If corporations are people, then corporations can go to jail.
You raise a good point that my oversimplification obscured.
do you have a reference to just how bad they were? I'd like to learn more. This whole sackler thing has been scaring me shitless because as a biochemist thinking about going back into biochemistry, my brain runs around in circles about how badly a small bit of uncertainty could be turned around in circles to screw me over, even if I believed what I did was in the best interest of most people (like what happened to Merck + Vioxx).
I'm not even sure that would apply here, since Uber drivers are not employees.
> So there's a clear correlation

But is there clear data? Seems pretty straightforward data to collect...

You can also correlate it to price of bitcoin, smartphones, avocado futures, airpods and social media /s

Finally, how much professional training to minivan and MPV drivers get?
You're massively under estimating how many tablets the sacklers sold.
Whether Uber's position on AB5 is correct isn't relevant to the question of whether they should be legally prohibited from saying it. The government can't go around banning people from having the wrong opinions on laws.
From what I can tell, the link between Purdue Pharma and the Sackler's campaign to get opioids prescribed to patients with pain - and indeed, their use to relieve pain in general - and the widespread opioid addiction and overdoae crisis seemed to be extremely tenuous and mostly pushed for political reasons. Basically, we wanted someone big and high-profile to blame that fitted into all our nice neat existing narratives about evil megacorporations and the wealthy, and plenty of journalists and prosecutors were willing to give that to us.
Gemini clients could easily add support for images: if a URL ends in .png et al, fetch it and if the mimetype is image/* then just stick it in the page. Tada! Some clients already do this.
Nellie Bly, the pioneering journalist who feigned madness to expose asylum abuse
They aren't employees yet. Apart from that, threatening to exit a business in a region isn't the same as threatening individual employees. I'm sure Uber will be happy to have them in Nevada
That makes me imagine The Sopranos, and the mob telling the staff of the strip club how important this law not passing is (or vice versa), and how the implication of not voting for it isn't necessary to say out loud.

There's a great Mitchell and Webb sketch about the issues with leaving things be implicitly communicated rather than explicit. (NSFW) https://www.youtube.com/watch?v=VgX6JFoV0TM

And, if I left out a clip of Always Sunny In Philadelphia's take of the pitfalls of implication, I'd be remiss. (NSFW) https://www.youtube.com/watch?v=-yUafzOXHPE
> This seems inevitable as computers become more accessible to less technical userbases.

The only change is cost. Computers are more accessible because they're cheaper. My dad managed to figure out VisiCalc for himself back in the day, and he wasn't "technical", he was just in sales.

IMO there's an unfortunate tendency nowadays to infantilize users.

How can we say simultaneously that "computers are the future" and also accept a situation where the majority of people are just assumed to be technically incompetent and incapable of learning?

> companies have incentive to minimize support requests.

In my experience, for example supporting my mom, there's no difference in the volume of support requests. The only difference is that you can actually fix problems that occur on the Mac, whereas if someone experiences a problem on iOS, they're basically doomed.
I totally agree: in my view, Quibi's failure was in the cards from the start. Nothing about their model made sense to me personally, and their failure to pivot or iterate seems like a huge business mistake.

I'm just making the point that PG and many other SV founder/VC types don't feel the need to take another swing at Quibi on Twitter because most companies (good ideas or bad) fail anyway. And if they had succeeded, by 2027 everyone would have collectively re-written history to think that Quibi was a super-obvious idea from the beginning.
The “10 tomato plants per person” number makes things look pretty dire, in my eyes.

World population is about 7,800,000,000. The population of Germany is about 83,000,000. That makes roughly 940 tomato plants to offset the CO2 emission of one person.

Even putting that number aside, tomato plants are not exactly small plants. A significant part of world population won’t have the leisure to keep even one, let alone ten, tomato plants (or the equivalent in other plants). Think people who live in slums, people who live in dense areas (e.g. people who subsist with minimum wage in subdivided apartments in HK).

Yes, we should definitely grow plants, but even more so, we need to consume way waaaay less.
Seems like it would be good for anything you would put in a stream e.g. encryption/decryption, encode/decode, compress/decompress, parsing, filtering, routing, etc.
But can I write a shell script to purchase a big mac?
Determine people who have opioids prescribed without a real need.

Wean them off gradually, using known programs for quitting opioids. Work with them as with patients, for once they are addicts, they are the suffering party.

Make the makers / prescribers which acted in bad faith to foot the bills. They made the damage, let them pay for repairing it.
I don't see why I wouldn't trust a charity to do what they claim, filtered by their brand reputation and public opinion (exactly like I would for a corporation).

I can't trust the government (and education) to do anything but try to hoard more money at the expense of citizens.

The only problem is the governmental parasites polarising and dividing the people, while increasing spending every year.
But how does the fear of the NSA abusing my privacy compare with other random fears that I live with, like car crashes, disease, criminal conduct by a colleague, etc.

I have trouble ranking how concerned exactly I should be about the NSA
You are correct. Facebook has done multiple presentations where they showed how they have a IPv4 load balancers/translation layer at the edge that converts everything to IPv6... but native IPv6 is well, just that, native.

There's no translation layer needed.
I hope that the actions against google will also be leveled at apple as well.

For example, apple has built deep linking into their browsing pipeline (allowing phone applications to snoop and intercept registered URLs). For example, if the amazon app is loaded, any web/email/imessage activity to an amazon url gets sent to the app.
a-Shell doesn't try to run a full linux environment; it just gives you access to a lot of common utilities, which presumably was an easier sell to get on the app store. The fact that iSH Shell allows you to download and run arbitrary code from alpine's repos is what made many think that it'd never leave TestFlight.
I keep reading it in this voice: https://twitter.com/Octopimp/status/1319394893215666178
I think we should remember that Uber is the same Silicon Valley ‘startup’ that created a ’God mode’ where employees could get access to celebrities’ information and stalk them.

Uber is a profit seeking entity that aims to ‘move fast and break things’ as the SV culture promotes, which includes now violating worker’s rights with Prop 22.

Aside from that, this isn’t an ‘a few bad apples’ issue, this behaviour originates from deep rooted systemic issues that have to do with (Platform) Monopoly Capitalism, which has the contradictory and exploitative capitalist system as a basis.

"Intellectual Property is the oil of the 21st century"

— Mark Getty

The Intellectual Property/Monopoly system is at the root of it the most recent wave of exploitation. ‘Intellectual Property’ monopolizes possible configurations, and robs people of the ability to learn about the basic building blocks of technologies and useful tools.

How can we pretend that one Silicon Valley entity and owner can make the best use of a given discovery? I would even argue that if we would have better access to various technologies we could stop climate change. In other words: if the ‘Intellectual Property’ system didn’t block most humans that are alive from asking questions, and using their curiosity to learn and grow, we’d be closer to a more beautiful world our hearts know is possible.
No we just need to completely get rid of all regulations and Corporations will totally stop doing nefarious things becuz of da market...

They only do bad things now because those Commie Democrats put regulations on them.

/s
This is my point exactly: Dropbox isn't a super obvious niche. The top-rated comment from the release on HN: https://news.ycombinator.com/item?id=9224

> I have a few qualms with this app:

> For a Linux user, you can already build such a system yourself quite trivially by getting an FTP account, mounting it locally with curlftpfs, and then using SVN or CVS on the mounted filesystem. From Windows or Mac, this FTP account could be accessed through built-in software.

Now that Dropbox is a unicorn (and there are dozens of other competing products, some of them unicorns in their own right), it's easy to pass this off as an obvious idea. But plenty of people at the time thought it was a bad bet.
In the iPadOS settings for external keyboards, you can remap caps lock to escape.
There's no "I'm telling you the truth I'm really going to fire you" exception.
They need California much more than California needs them. I wouldn't be surprised if strong-arming their employees is the only leverage they have.
It's not necessarily a tantrum.

The failure of Prop 22 will cause a massive disruption of an existing marketplace. No matter what you think of the morality of the existing setup, the failure of Prop 22 will force some large structural changes to how it operates.

It seems likely that this will cause ride-sharing not to be economically feasible in rural areas where per-driver utilization is low.

Operating in SF and LA will likely remain profitable but many drivers will be forced, by AB5, to stop driving. This will increase wait times and increase prices and cause lower ridership.

It's very possible that Uber/Lyft will decide that the overhead of being an employer is not worth the reduced revenue, it's not like they're making a lot of money in the first place. It's also possible they'll decide they won't want to dilute their brands by offering a service which makes you wait 7 minutes for a ride.

It is, of course, also possible that they'll decide to send a message / throw a tantrum, but your comment implies this is the only explanation. It's definitely not the only possible explanation and I'm not even sure it will be the most likely explaination.