skysight-inc/HackerNews huggingface dataset:
But structural biology can be very inefficient.

Let's say you want to know which residues in a protein are important for a particular function, so you can tweak them to improve function.

You could

- spend months or years solving a structure of the complex then look
at the structure and look at the direct contacts - then mutate to various other resides to
see if they affect function ( finding out that even with a structure of
the complex your chosen list is far from 100% correct )

- look at sequence alignments and then make a library of millions of variants and screen in a couple of months.

The first feels better as the glorious scientist is doing 'rational design', however it can be much more hit and miss and slower and more expensive.

As I understand it, one of the things about Cryo-EM is it's potentially much faster/easier than previous methods - but even so, looking at the structure doesn't get you to the answer direct - it's still very much hit and miss.
that's not really a thing you do in PHP, outside of frameworks like swoole/roadrunner. by nature it's a fire/execute/die shared-nothing model
> As a bootstrapped founder when I was younger, even dating was awkward. People considered me to be quasi-unemployed, despite working 80 hours a week.

It is awkward-- and frankly, unhealthy-- to be working 80 hours a week. That's what people in cults do.
That's not really bad news, is it? It doesn't seem unreasonable to redirect all the money being spent on HEP projects into climate science. That high energy physicists have great employment options is a good thing. It makes it much easier to close down those projects.

The HEP problems aren't going anywhere. Lets deal with more pressing concerns now and come back to HEP problems later.
Good. It's more important to cater to general privacy/security than to the kind of guy that already has a server running but can't be bothered to install certbot.

For a non-expert setting up a website from scratch, they can get the whole stack set up automatically and it won't make a difference to them. Especially since they're probably on shared hosting; shared hosting is much closer to the ideal of having the website be a folder of html than running an entire server.
But they do have to be, otherwise they would go out of business. If someone can choose when and where to work and they choose a time and place where people mostly don't need rides, they mostly don't do any work or make any money. Which they may be fine with if they're willing to be signed in for 40 hours a week but only work 10.

If you force them to a fixed hourly wage, you can't hire that person and still let them work those hours in those places, because you'd be paying them for 40 hours while they're still only working 10. So the now money-losing employee either gets a pink slip or has to work different hours.
Coca-Cola. I really like soda. I have zero vices other than my love for soda. I don't drink alcohol or smoke or anything like that. It's just soda. So if Coke went out of business, I'd be devastated.
>So you sell your X to someone who does want to spend money and they give you something in return (e.g. cryptocurrency) that you can save. Or you just buy some object such as gold jewellery that has a measurable value.

presumably if they're going through that much effort to implement this, they'll prevent this from happening. eg. https://en.wikipedia.org/wiki/Executive_Order_6102
Well VR is a thing now for $300. And there is tiktok and snapchat as far as social media goes. Companies are slowly marching to deliver AR as a product too. Consumer drones are another thing along with cheap digital large sensor cameras, and once something like waymo and boom delivers, those would be revolutions of their own. Also solar is cheaper than coal now as an energy source, and complete DNA sequencing now costs $1000 vs $100’000. Electric cars are now something that the upper-middle class can own practically.
You won't ever know if the company has erased your data. What incentive does a company have to clear a hard drive with your info on it, if you're not paying them? The only way to re-balance the system is via legal fiat.

Free market works when the company depends on the customer ("consumer"). As soon as you sign up, most free services don't have a free market incentive anymore to service the customer.
> I'm reasonably sure that it was a pottery class (or study) in which students/study participants were asked to produce either the best piece they could think of or as many as possible. I think it was actually a study that I read about.

> It might need some internet sleuthing to find it. I'll try later.

The earliest reference I am aware of is the 1985 book "Art and Fear", at the beginning of the section on perfection:

https://books.google.com/books?id=yGf6CAAAQBAJ&lpg=PA77&vq=c...

The book doesn't have footnotes or a bibliography, unfortunately.

I think people take away only part of the lesson from this anecdote, and miss the implication that, since getting an "A" was trivial for the "grade by quantity" group, students were not just encouraged to practice, but were also free to experiment without fear of failure (after all, they could easily make up any shortfall by firing a few unworked lumps of clay to get to 50 lbs).

But I wish we had data on the number of students, distribution of grades, number of pieces each student made, etc. because it should be obvious that we can't extrapolate too much from the fact that some data points on the "high quality" end of the distribution were all from one group. The three best? Ten best? The best half? What was the size of the class anyway? Did anyone try to game the system by just firing 50 one-pound lumps?

In some sense, this is a bit like evaluating software based on SLOC, and we all know how that ends up.

It should also be obvious that none of the students had any particular incentive to explore the "delicate" end of the possible artistic design space, although at least the "quantity" group wasn't penalized for doing so. So, if no students cottoned on to the "50 1-pound lumps" hack, I would expect to see coffee mugs rather than teacups in their work.
How Does the New Azure Communication Services Implement WebRTC? (Gustavo Garcia)
I've started using the term "Mitt Romney unemployed" for "not working but no pressing need to", as a reference to his famous gaffe about "I know all about unemployment! Heck, I'm unemployed, myself!"

https://www.thedailybeast.com/cheats/2011/06/17/romney-ribbe...
Bot posing as human fooled people on Reddit for an entire week
PHP has (almost) complete strong typing system and all the bells and whistles of OOP needed to implement said systems using proper patterns and methodologies and make it modular and testable enough to be robust and supportable for a long time.
> The electoral college is designed (from the start) to prevent the larger, more populous states from dominating the country. Seems to be working as designed. And doing a good job as a system.

Not really. The college disenfranchises Wyoming Democrats and California Republicans a similar amount.

It's the Senate that protects smaller states, since each state gets two senators.
Rethinking Attention with Performers
Show HN: Unix filter to colorize tags stored in filenames
In this comment and also https://news.ycombinator.com/item?id=24867774, you're misinterpreting HN moderation. If you look more closely you will see that it is different than you're imagining. For example, it's neither saying nor implying the things you're mentioning here.

(I'm not saying this to defend anything—I just thought you might be curious.)

In the current discourse there are only a few (if not merely two) squares that people are supposed to occupy, and the prevailing feeling is "you're either in my square or the enemy". But operating a community like HN requires not functioning that way, and we don't function that way. The goal is to open up space for something more interesting and complex than angry bashing. That's not so easy. This thread actually did a pretty good job of it, except where it got sucked into angry bashing.
On the state of systems research (2014)
The whole world is using "end-to-end encryption" using keys facebook has. Lucky us
There are limits. You’ll be restricted by timezones and your ability to function in them. WFH doesn’t mean async.
Tried it without registering, the idea is great but the UX could be made better.

For the 5 songs to rank, for example, I only enjoyed 1 while the rest were unlistenable. There should me be a way for me to delete the ones I don't like and get new ones in until there is a set of 5 good ones worth ranking.

For the yay or nay rank I was getting good songs, but there was no way to mark them as such. To make this site go viral and enable the exposure you strive for, publish rankings and enable visitors to randomly hear new music and rank it.

The domain and the idea is great - I am sharing it with friends already.
Lots of negative descriptions there. But even with one-man-one-vote, the winning side seizes the voting power of those voting for the loser(s).

They're all ways of making a decision. In the end the votes are tallied somehow, to some goal. We used to have different goals 100 years ago.
Yeah, this is some real /r/restofthefuckingowl content. I especially love when there is one particularly tricky bit in a build and you find a video talking about how to make it so you watch the video and they skip right over the tricky bit to cover the easy stuff in excruciating detail.
TX and FL going blue? Have you seen the early voting? Rs are LEADING in Miami-Dade, a Clinton county. Voter registrations are crazy for GOP in FL and the D-R voter gap is only at around 130,000 (used to be 650,000 when Bush won FL in 2000) Other than polls, I have yet to see any indication that FL will go blue despite going red in 2016 and then electing an R Governor on 2018.
Well our most up-to-date understanding of the solar system's orbits is based on general relativity. That's how we explain Mercury's precession. Is that your failure case?
> Everybody of us used to be a huge apple fanboy, now every one of us hates them with a passion.

Neither of these extremes are healthy attitudes. It's a company, making machines. That's all there is to it.
Right good arguments in the political sense. A highly organized, well connected, motivated group of people that write excellent funding proposals, with a track record of Nobel price worthy results and the ability to execute on >10 billion dollar projects on the time scale of decades. There aren’t that many people like that around and they happen to like to smash atoms.
Yeah that's sort of silly. The implications of a non-BTC-based standard with the intent of enabling cross-border more effectively is:
- IMFcoin, UNCoin(and the conspiracies around global banking cartel actually take flight because yeah actually that would be nuts)
- EUcoin, USAcoin, ChCoin (imagine the geopolitics...)

A digital currency that directly fits the digital use-case being described by these papers written by central banks, that is in turn ignored by these papers, is sort of like talking about WW2 without mentioning Germany's role.

I can definitely understand the aversion given the implications of a non-CB controlled digicoin, but just ignoring its existence really blows a hole in the intellectual rigor of these whitepapers.

Ultimately, the network adoption will play out as it plays out. We don't have USAweb and RUSweb (maybe moving toward that, but different topic), we have the decentralized, multi-party, ICANN/IETF/private sector/public sector-led The Internet. When you track how the Internet came to be, and how it's actually controlled now, it starts to look a lot like the Bitcoin network's growth plan at the moment. What will be will be. Once it gets analyzed as a network protocol with digital native payments, vs. a digital currency on the regular internet, the blind spots in BTC criticism start to show.
Is this your project? If yes, I'd suggest submitting an info page as a Show HN. It looks interesting, but videos generally don't do that well on HN.
MSFT could have opened up retail stores with their boatloads of cash like Apple.

But they didn’t want to take the risk with a low margin high cost center activity like providing in person support and expanding headcount. Hence no reward.

And with their recent closing of Microsoft stores, it’s clear that they are doubling down on rent seeking from Office and Windows licenses.
you mean $_SESSION? that was there since at least php4
Is it possible to zoom out? It's hard to place events relatively to each other if you can only see 2-3 on the screen at a time.
could it be that in some languages (like my language for example) serious is kinda of a synonym for large?

I've been downvoted at times for using it to mean exactly that, but I can't help it after more than 40 years of thinking in a language different from English.
Can you share any typical settings you recommend? I’m experiencing small amounts of artifacts, would love to know of someone’s “safe default”. Thanks!
> The college disenfranchises Wyoming Democrats and California Republicans a similar amount.

No, the States of California and Wisconsin do that; the Constitution and the design of the electoral college do not mandate winner-take-all allocation, and not all states choose to do that.

(The EC structurally incentivizes it, perhaps, in the same way that it definitely incentivizes doing everything that the rest of the Constitutiona and laws let you get away with to more literally disenfranchise people by preventing them from being eligible or practically able to vote at all, but it doesn't actually do either of those things, it leaves it to the states to choose to do them or not.)
> If they really believe the accuracy of their models, they should literally be betting the farm on a Biden win.

I mean, maybe they are; how would you know? (Though it would seem vaguely improper; not sure about the journalistic ethics take on this but it's at the very least not a great look.) Presumably the money a few 538 employees could bet wouldn't shift the betting markets very much.
Tom Holland, the historian, was tweeting about Boswell and his biography of Johnson recently. I was unfamiliar with Boswell or his biography. Between Holland's description and now this review – I will read this book.

https://twitter.com/search?q=%40holland_tom%20boswell&src=ty...
What are your thoughts on simply “self-employed”?
Be Careful of Aljazeera
Yes it does prove the point. So if I look at these docs[0], this tool, not only does it do translate/rotate/scale, which are the most fundamental image transformations in 2D editing, but it also does shearing and perspective transformations which are rarely used by comparison. This tool was clearly designed from an implementation-driven perspective (just put all the affine transformations in one place) rather than a UX driven perspective (no designer places these tools together conceptually).

On top of that, this tool still sits along side other single purpose tools for scaling and rotating, which are the first results if you search "how to rotate in GIMP", so why should I even expect this tool to exist?

This is not intuitive UX which is "trivially different" to PS, this is a mess which can only be learned through laborious trial and error, or reading the documentation like a book.

[0]:https://docs.gimp.org/2.10/en/gimp-tool-unified-transform.ht...
Smaller requires more innovation than larger.
Great combination of modern tech and design hope it helps a lot.
Parenting doesn’t do what I thought
Can AWS API Gateway Act as a Load Balancer?
Expensify CEO emails 10M customers urging them to vote for Biden
Huh! I stopped learnin' compilery stuff after SSA and was unaware of the approach. If anyone else is wondering, here's a good Reddit thread on bblock parameters:

https://www.reddit.com/r/ProgrammingLanguages/comments/9z8qu...
Instead it allows the smaller, less populous states to have outsizes influence.

Possibly the systemic cause is the excessive influence of the presidency.
Probably thinking of a visa run to reset the counter.
> Or adopt D.C. statehood

That would only add two, unless you also had a reapportionment act. Same with adding Puerto Rico as a state.

Edit: As pointed out below, this is wrong. Since DC already has 3, it would actually lower the number by one, so this would in fact give an odd number.

> The House can and does have ties, even with an odd number of members; members abstaining or missing votes in the House are more common in the House than the EC.

Yeah, but when that happens, they just vote again. The are never deadlocked from a tie.

> You could extend the same EC voting arrangement to, say, (to pick an odd number of territories) Puerto Rico, Guam, and the Northern Mariana Islands as D.C. has now.

It would make sense to do this for Puerto Rico, whose population is greater than 20 states. But all the other territories are smaller than the smallest state, and that would give them outsize power.
I think it would need to be a lot closer than 2%. Obama won Florida by 0.88% in 2012[0].

[0]https://en.wikipedia.org/wiki/2012_United_States_presidentia...
This is still possible, how do you think isn't anymore? As example I mean
Reality has a well-known liberal bias, after all.
Epicycles have nothing to do with orbits. They were state of the art science when Earth was at the center of the universe.
We'd all probably miss "The Compass Group", the world's largest restaurant holding company. Never heard of it? Dozens of restaurant chains would be gone.
> What's the point in picking your favorite party if the outcome would be worse?

If I'm in Wyoming, what's the point of voting for Biden? Should I not just go ahead and vote for Trump?

And as a I mentioned in my other comment, I have met quite a few third party voters who care greatly about things on which they believe Hilary would have been worse than Trump. Don't jump to conclusions on what is "better" for them.

> I never made the claim that voting for third party in a swing state is bad. But yes, if the state is sufficiently "safe", the disadvantage of voting third party is marginal.

My point wasn't about voting third party in a non-swing state, but about voting for the clearly losing party in said state. Why bother voting for Biden in Wyoming or Trump in Washington? That's wasting the vote. It's a bigger waste than what you are talking about. If you lean towards a third party, voting for Biden in Wyoming is the ultimate waste: You vote for someone who has no chance at winning, and he's not even aligned with your political perspective. When it comes to "wasted" votes, these vastly outnumber those voting for 3rd party candidates.

I guess growing up in a country where voting wasn't allowed does give me a different perspective than you. And people complaining incessantly about Nader/Stein voters is a pretty strong signal that their vote wasn't wasted.
Counterexample: I have been WFH since March. I live in a small condo and having to turn my also small dinner table into a cluttered office (USB mic cable, laptop power cable, notepad, external mouse) just makes me feel like I am never really not at work. Even when sitting by the TV, the 'work' is but a mere 6 feet away.

Ironically, my productivity has also been getting measurably worse.

I've realized that I need IRL interaction with my co-workers that's outside of scheduled Zoom calls. I like running into them in the break room and making small talk while making a coffee. I am in a large organization, and having that interaction also gets me talking to people who aren't my direct co-workers.
It is the latter.

It is possible to implement a condition system on top of any language that has dynamic variables, a `finally`-style construct and some mechanism for unwinding the stack. Since dynamic variables are implementable on top of lexical variables and `finally`, it's basically just about unwinding the stack and `finally`.

The main issue is how a condition system would fit with any existing system which likely works by immediately unwinding the stack rather than allowing to wind it further; that's the case e.g. in Java or C++.
You have to approach it with a pretty wide angle lens, but the better analogy IMHO is comparing BTC to other early day currencies.

Have you looked at USD vol in the 1800's? Reichsmark vol? From that angle, vol of "proper currencies" in their early adoption days tend to start looking a lot like BTC vol. At a minimum, BTC today to USD today isn't an apples:apples take at all.

In my mind, this starts to damage vol = bad BTC arguments in terms of analyzing BTC's adoption. potential.
I think your situation as retired sv programmer might be very different to someone who drives Uber to make ends meet.
Once for curiosity I tried to read about BLM movement. I wasn't sure if I was reading a historic document of the movement or a BLM demonstration cheerleader.
I think `tree` is a bit confusing for what is essentially still linear vertical diagram. You can imagine you could have a layout with actual branches.
People _really_ struggle with probabilities (which is why 538's 2020 model page has a cartoon fox to remind them about probabilities, and headlines with visualizations). To a lot of people, saying "there's an 80% chance of THING happening" means "THING will definitely happen".
Or you predict you'll be drinking beer and playing video games when in reality the apocalypse is happening. It goes both ways.

We either give up on trying to predict stuff or we do our best and refine our models over time. If you (and by "you" I mean anyone) have any criticism to any specific prediction please say so, science depends on it. But these dismissals of "it's too complex" don't really help with anything.

Also keep in mind the article in question only mentions the predictions that did not came true, for instance https://www.sciencemag.org/news/2019/12/even-50-year-old-cli...
In principle most other compiled languages could have macros that manipulate the abstract syntax tree. Lisp makes it easy since there is little separation between the source code and AST, but Scala now has macros despite using totally different syntax.
but that’s just the point, when you break down social structures into finer and finer units (the individual, at the limit), you realize that status has all sorts, and is relative to many social groups. hence, the position that statuses outnumber people through both the multidimensionality of social groups as well as the multidimensionality of status itself.

a singular global social order is a fiction we don’t have to choose to believe.
Sure, but that also doesn't mean you can't work just fine doing 80 hours/week in some jobs and not be fine working 80 hours/week in others.
>The Le Corbusier spirit of zoning

It's not Le Corbusier. Zoning in the USA started in the late 1800s, an effort to regulate light and air in cities, and turned by the early 1900s into an effort to keep certain industries and ethnicities out of "good" neighborhoods.

https://www.strongtowns.org/journal/2017/6/28/a-history-of-z...

https://www.bloomberg.com/news/articles/2012-06-19/the-birth...

https://fee.org/articles/the-racist-history-of-zoning-laws/

https://www.kqed.org/news/11840548/the-racist-history-of-sin...

https://oldurbanist.blogspot.com/2016/02/american-zoning-as-...
Perhaps it can be BS but perhaps (and perhaps unfortunately) it can also be a necessary BS credential/rubberstamp if you want to move into management at big tech.

And if it can flip you from an marketing engineer in a fading semiconductor fabrication (Applied Materials) industry into a leading a $1-2 Trillion adtech/AI company and equip you with the skills necessary to handle being on the frontlines of a DOJ trial.

https://magazine.wharton.upenn.edu/issues/spring-summer-2020...
If there is an accident you'll have a giant wind spill to clean up.

But more seriously large chunks of spinning metal can turn into deadly flying knives when things break. With a properly engineered windmill this is extremely rare and usually requires a severe amount of neglect. With some DIY project built from scraps you probably shouldn't mount it anywhere near people.