skysight-inc/HackerNews huggingface dataset:
> The original Remdesivir trial by the drug company was a high quality RCT (randomized control trial) - except that they stopped it early once they saw a statistically significant positive effect (even though the effect was somewhat underwhelming: just a couple fewer days of illness). To me this moving of the goal posts invalidates the quality of the RCT.

Based on what I've seen discussed, ending trials early is a fairly common (though admittedly contentious) practice in medical RCTs when you're dealing with very serious illnesses, especially when there are no alternative effective treatments[1].

The issue is that there is a tradeoff between an abundance of caution to procure conclusive results and giving patients access to medicine which "clearly helps". In an ideal world you would run every RCT for several years to figure out any possible long term effects and accurately determine efficacy, but there are many circumstances where you could argue doing so (if it's clear the medicine works during the early stages of the trial) is more unethical than giving people medicine which shows some promise to work.

But it should be noted that such trials are still solid science (the trial was an RCT), it just means you cannot take them as evidence of long-term efficacy.

[1]: https://www.ahajournals.org/doi/full/10.1161/circheartfailur...
The original text by Derek Lowe is available at https://web.archive.org/web/20200311135536/https://blogs.sci...

And Derek Lowe's summary was unchanged in his edit:

> My personal opinion is that I like the chances of this drug [remdesivir] more than anything else on this list, but it’s still unlikely to be a game-changer.
I think that would be covered under the idea "Lead by example". When the manager is competent to understand, console and provide guidance to the team when they're struggling - even slight slivers of technical skills and knowhow, the rapport they build is unbreakable.

The idea is to genuinely belong to a team, not just on an org chart. When troops are in the battle field, they form unbreakable bonds because they have trust, got each other's backs and there is absolutely nothing artificial about it - life is on the line. More often than not, I've seen managers appear genuine but are not internally so and it will surface in future if not now.

Also, corporations, midsized companies and even small companies have this idea of not speaking the mind. Instead, massive amounts of bullshit corp speak and lipstick is put on the pig to do a quick dog and pony show for the upper management. Managers that suck up to upper management lose their support from the troops. Once that's done, there is no going back.
"Nim isn't quite as simple as Zig"

My experience is complete opposite. I find Nim to be very simple and Zig to be not simple. What's the problem with Zig? I find the documentation to be chaotic. I believe that this is largely due to the rapid pace of changes (including changes that break earlier code).
You haven’t watch the reInvent talks have you?

But if you try to use the same schema design from a standard Postgres database and use the same query patterns, you will be sorely disappointed. Redshift uses a columnar store and is an OLAP database as opposed to Postgres which is a traditional database.
France, Germany, Romania, Switzerland and Macao are all not Scandinavian. The German Wikipedia is missing most from this list but also includes Austria and Liechtenstein.

But I thought it was more common as well, as it seems pretty fair.
Yeah, though at least JIRA got a little less painful lately...
I mean... no one is forced to use an Electron client to access IRC, so. That's kind of one of the main benefits of using an open, standard protocol like IRC.
The fundamental difference in ML of you work with data, where as in s/w you work with rules.
It's a subtle difference but I believe is very profound. It's very hard to develop intuition around data and most s/w devs treat data as rules.
It's not entirely the fault is DS folks who happen to come from non s/w background and vice-versa.
In my mind the management should understand that their is a gap and seek to help close the same.
Show HN: Guitar tube amp plugin based on spice simulations
Saving democracy via dictatorship?
> Because C doesn’t have good programming constructs for asynchronous calls or exceptions, code tends to contain either a lot of weird state machines or tons of nested branches. It’s horrible to debug problems that occur.

Linux is in C though. So, what is really going on?
You did not mention anything at all about "narcotic."

While, you write that you don't want to make assumptions, it sounds like you are already set in thinking there is just two issues.

There is much more than just the black and white world you created with "psychedelic" and "opiate."
Good job taking responsibility, Matt. Handling this the right way.

I do think there's a larger discussion about trillion dollar companies just forking a project and announcing it as a new feature for their platform without even talking to the original creator.

If there's anything to improve, "reach out first" will be a start.

It's open source. You don't have to reach out. There's nothing legally or morally wrong with what you did. But you can do better. A trillion dollar company can do better to act grateful to be in the position that it's in. To be seen as a leader in a space instead of as a consumer of free work.
The Guardian is a bigger threat to democracy than Facebook. At least Facebook allows some level of political dissent. The Guardian is non-stop one-sided political propaganda masquerading as news.
Article reads more like "I became a user of Cloudflare's CDN" than "I setup my own personal CDN"; perhaps I'm missing the point though?!
Im getting autism vibes from this article more than sociopath vibes.
NREL Advances Thermochromic Window Technologies
> standard client across multiple operating systems

In my case, it's suboptimal. There's a multi-second delay between when I type and when the characters show up on the screen. If I were able to use an OS specific client that didn't have these performance issues, then it would be a far better experience.
Some phone providers give free services to block these calls like Nomorobo.
Or laser cutout to project a pattern behind it, ambient lighting, or even project a pattern, same for camouflage or different for contrast on a wall behind it.
You should really be using an OAI to let cloudfront get your content, serve out of there with a local cache policy..

https://docs.aws.amazon.com/AmazonCloudFront/latest/Develope...

Open bucket is an antipattern here.
I was thinking the same thing. Plus, all the miscellaneous administrative tasks (HR, training, marketing, etc.).
Sidekick (hiptop) let you interact with your AIM contacts for basically free, at a time when many people were still paying 30 cents apiece for SMS messages. They even had a data only plan.

I knew a bunch of deaf kids around that time and they all were enthusiastic Sidekick users.
> the communities you describe definitely still exist

I agree that they do exist. But they don't seem to be mainstream as they once were, and I'd very much like to change that.
> slander

Slander isn't criminal, it's a civil issue. And social media companies don't have to worry about that _because_ of section 203 protections.

Under US law, yes, social media companies can do what they want in this particular case. But should they? They are massive and they control narratives. The fact that we have real freedom of speech proves this because we have other channels to discuss and bring attention to this issue.

There is another angle: Because of FB/Twitters massive size and control over their audiences, is allowing some stories and blocking others election interference? It most certainly is.
Amen. For all the convenience of streaming, it really seems like we have gone steps backwards.
A Passionate Startup Pitch Is Powerful–But Can Be Misleading
Capitalism doesn't _require_ the heartless pursuit of shareholder value. You're confusing the system with one particular ideology.

Changing incentives, standards and cultural norms absolutely is possible within a capitalist system. In fact, it's required. Otherwise, capitalist economies quickly descend into oligarchies with skewed markets that favor those with all the capital.

If profit were the only motive without any other rules in play, that wouldn't be capitalism at all. We need interventions in order to preserve a healthy system. To suggest otherwise is to defend an ideology that isn't capitalism itself.
I don't see anything wrong with this tweet. At the time, this was the only information available about the disease, and the source and preliminary nature of the research are clearly stated.

One week later, the WHO had already conducted its own field visit in Wuhan and concluded that human-to-human transmission is likely taking place [1].

[1] https://www.who.int/china/news/detail/22-01-2020-field-visit...
With the risk of sounding esoteric or self-help I have to admit that both cold showers and wim hoff breathing method have at least made me less stressed out and more resistant to cold and sudden change of temperature.

It started out of curiosity while in my meditation conscious living mood about a year ago, but ended up something I exercise daily since it just feels good to me.

Most notably I noticed that my legs where no more chilly or sweaty with no reason and that my hands are not as cold all the time they where before. As for breathing I noticed that I am much more relaxed on the days I do it then I don't but can't attest to weather this is just some placebo effect or not.

And I notice that I feel much less fly like effects than previous years or if they appear they last no longer than half a day.
Telecom providers are treated differently than Twitter and Facebook because they are essential utilities whereas the latter are not. Plus telecom providers have been enjoying govt support in the case of public resources (land use and radio frequency rights) in order to provide this public service. This govt support can be taken away.
As I understand from chekcing how to do it, designations in Openstreetmap are supposed to be done on the basis of signs on the ground and verifying the route by walking it (combined with local authority reference data, which I understand is definitive). If someone has taken an interest, the paths (and other features) in an area are likely to be in a better state in OSM than an OS map from some years ago, and possibly better than the master OS data. (Obviously mileage varies -- though one hopes not far outside GPS or satellite imagery tolerances.) I guess the place to start is https://wiki.openstreetmap.org/wiki/Access_provisions_in_the...
But how would this idea work on a national scale?
Ask HN: How to edit kMDItemXxx file metadata on macOS?
I was quite surprised today to realize that I couldn't modify file metadata (the ones that mdls shows) on macOS.

For vanilla metadata, like basic timestamps, touch is good enough. And for these things called "extended attributes" (quarantine, etc.), macOS gives you xattr.

But is there a CLI way to edit, say, "kMDItemBitsPerSample" or "kMDItemFSName", or the key/value pairs used by Spotlight? After one hour of research I couldn't find anything...
I'm not sure about a team that size, but Patreon seems to be working ok for some solo developers.

See Evan You (Vue.js) for example:
https://www.patreon.com/evanyou
Does it have SSO with Azure AD/Gsuite? that would make it a good deal.
That is interesting.
Art 4.9 Released: ASCII Art Library for Python (+ Font Typo-Tolerance)
If you want people to be able to work 15 hours a week and have enough to make ends meet- I think most people would jump at the chance, but capitalism is not the right economic system if that’s your goal. Capitalism is a machine that maximizes returns on investment; having people only work 15 hours a week doesn’t do that.

Also, there’s a hidden assumption in there that child care doesn’t count as “work”. A child needs 16 hours of care and attention every day and no economic system can reduce that.
What comes out is the corn shell, which looks like corn unless you poke at it

I've heard this, but never experienced it myself. No corn shell in my stool. I've also heard people say hot sauce is just as hot coming out as going in. I've also never experienced that (whew!). I do struggle with my weight, so maybe that's why? My gut microbes are extracting every bit of all the food I eat?
John Nagle is a commenter here on HN, and has commented on this very thing: https://news.ycombinator.com/item?id=10608356

I have also ran into this, but for me it was a periodic latency spike with steady but periodic messages. That latency spike went away when the messages were sent as-fast-as-possible.
> I salvaged some 13” LCD displays from old laptops and found additional matching displays on ebay.

The LCDs were taken from old disused equipment.

> I happened to have an Nvidia Jetson Nano

And the board was disused equipment too, it seems.

I find this kind of reuse very inspiring. Once I no longer need my old laptops, I feel like it might be fun to do something similar instead of shipping the whole thing to a recycling plant. You could even use LCDs that have dead pixels or other defects.

You could argue that requiring a 35 W LED lamp is wasteful, or the power used by the SoC (10 W max), etc., but together that's still about as much as a standard incandescent lamp.
I have to tell you. You did a terrible job at "communicating to the general public exactly what Pai is". You insinuated some sort of malfeasance on his part but said exactly nothing about what it is.

I used to want the government to not have its hand in things and I used to want the private sector solve issues. Now that the left-wing has overplayed their hand, they're going to bring potential harm on all of us by forcing the government to curtail their malfeasance.
Shipped using Mailchimp’s free plan without writing any code
So, a couple of weeks back, I shipped a product(https://www.setuphomeofficepro.com/workspace-setups) on Product Hunt made using MailChimp alone!

Right from the website hosting, landing page creation, collecting leads, and sending newsletters were taken care of by Mailchimp’s Free plan (less than 2000 subscribers). All it took was a couple of hours and a few cups of coffee.
Targeted ads in politics seem like one possible line; Dem SC candidate Jamie Harrison has been fairly open about how mobilizing voters who lean right to vote for third party candidates will help him win. With a few ads like "[3rd party candidate] is TOO CONSERVATIVE for Congress!" delivered to the right audiences, you could swing margins meaningfully [his campaign has paid for such targeted Facebook ads]. It's disgusting bad faith, but it's in the bounds of the game for now, so not doing it is foolish.
I don't remember that, but they got the thing about restricting travel wrong.

https://www.reuters.com/article/us-china-health-who-idUSKBN1...
I read the original posts. In my experience, most people do.
> As a result of the network effect, quasi-monopolies abound in Big Tech.

Yeah you're free to make an alternative, you might succeed, but if you get too big then the FAANG's will sue you right out of business.

Oh I forgot, or the FAANG's PR team will use the media to accuse you of being a home for trolls, hate, etc.
I guess my point that at least for the city I was talking about the bids were rarely a good estimate of the cost and time required. I'm not saying that they never make it for around that cost, but it is rare. The bids more reflected some complicated mating ritual to get their food in the door, then they deliver the bad news that the actual cost is higher the first chance they get.
Re: the Christianity part, I’d say that starting with the early 1800s until after WW2 the true teleological narrative was the idea of Progress (under different shapes and forms), it was only with the invention (and use) of the atomic bomb that its shine began to fade.
I, for one think that, "understanding manipulation" is an oxymoron. If you really understand then it's not really manipulation, right?

All these web platforms have grown through strategic optimizations for engagement. It's simple. But the tactical mecanisms they use to achieve this permanent engagement are complex and adapt constantly. Otherwise they wouldn't be good for the purpose. The point is not to keep you engaged once. It to keep you engaged at their (platform's) will.

You are right that it's not Facebook job to be less good at what they propose to do. But it is everybody elses job to determine if we want them (and others) to keep doing these things.
If you read that paper you referenced, the Mersenne-Twister actually ended the Ferrenberg affair. And where does it say that lower bits of dSFMT are bad? Is there proof for this statement?
Now I am not saying that dSFMT is the best RNG ever, far from it. It's just very decent, and quite fast.

LCGs have an awkward habit of bad projections in 2D.
How many of them implemented it?
Your salary is roughly equal to what you're willing to take to perform the role. If you move between cities with different costs of living, that number may change.

Don't think of it as "adjusting down" (since it goes both ways). Think of it as a different supply/demand curve. At least they're transparent about it, although I suspect some ICs get bumped up or down based on their performance.
*Amarok
I concur and I'd bet it's like saying "you've probably noticed kids these days are no good". It's something everyone in time always experiences.
I didn't know "hydroxychloroquine truther" was a thing. I do find the 142 positive studies to be compelling argument. The science does indeed seem to be in favor of the drug. But I'm not a doctor or researcher so my opinion is worthless.

https://c19study.com
Yes, I do not think so. I expect Facebook's goal to be to maximize shareholder value within the bounds of regulations.

I do not expect an entity such as Facebook to behave in any other way.

From Facebook's perspective, the current value system is possibly distorted, for example, because of a lack of competition. Suppose another social platform would enter the picture, and users would flock to that platform because it has a greater social responsibility. In that case, it might become Facebook's best interest to be more socially responsible as well.

However, that has not happened yet. It is making me believe that the burden to solve this issue is with regulators, not Facebook.
Some people are easy to satisfy I guess
Does anyone know if this announcement was spurred by the recent Twitter and Facebook restriction of posting links to the Hunter Biden emails story from the NY Post?
BTW: I enjoyed looking at your code. It shows a clean, disciplined, quality approach.

I'm big on having an open portfolio. I think that it is a really important component in interviews.

I think an almost perfect interview, is for the prospect to supply some projects, and the interviewer then asks them about their submissions.

Like for me, since I do device control and communication software, a good discussion might be around the patterns that I use to synchronize local model with the server state (spoiler: I use what I call my "staged model" pattern, which I'm considering farming out into another one of my general-purpose SDKs).
When I go to a restaurant and I don't outright dislike their food I am inclined to go there again even though there might be better places in the city.
At my last job I had an interesting (nice) experience. My boss wasn't an engineer, he was a project manager, but that didn't hinder him. I think what made him successful was that he cared. He'd say over and over, "I'm not a developer, I need help understanding." We would sit in a meeting and walk through problems. He was very calm and patient and acted genuinely interested in what the problem was. He would ask questions about what he didn't understand, and trust us on the things that we would say. It was a great experience. When we said we had a problem, he tried to understand and relay that to the necessary people. When he couldn't we'd accompany him to explain the details.
Why do articles like these make it seem like it was written by a guy targeted by an engineering manager?

"Like if I were in his shoe, this is how I would treat myself."
How do we know if it was the meditation, the snow bathing or the breathing exercises that had effect?
Interesting. At the risk of mentioning another trigger word I'll say the importance of supporting your community comes up a lot in libertarian circles as well. I think it shows that regardless of your political leanings or opinions on the responsibilities of the government, people in general value community and support circles.
You can just as easily argue that services cost more because we expect more from them. You now need to make sure those with disabilities are covered, that the environment isn't damaged, that workers who build them aren't abused or die, that waste is disposed of into something other than the local river, that the thing looks aesthetically pleasing, that a bidding process took place so the governor's cousin doesn't get all contracts, etc, etc. Things seem cheap when externalities aren't included but that doesn't mean they're actually cheap.
Think of him as the early warning siren that some thing is wrong. He didn't propose a solution, that comes from discussion. Complaining about a lack of solution is just complaining about what you got for free.
You expect too much of hacker news
> To watch the stream from VLC on your computer, run:

> nix-shell --packages vlc --run "vlc https://dash.nixcon.net/dash/master.m3u8"

I thought this was pretty cool, but unfortunately, this doesn't work on macOS...
I find it odd that he heads with the least defensible of all these examples: You've probably noticed things no longer work as well as they once did. For example, the store's online inventory says something is in stock and when you get to the store, it's not on the shelf. A small issue, but telling nonetheless.

This has never worked! And widespread online inventory systems date back, what, 10 years? This is a weird place to begin an essay about how good the good old days were.
Scratch that: a non-vanity domain will do for that. Comment misunderstands question.
Can you provide a source for this? The best I can find is that he had a knife on the floor of the truck. But was otherwise unarmed. This is consistent across all the main sources I've checked.

1. https://www.usatoday.com/story/news/factcheck/2020/08/28/fac...
2. https://en.as.com/en/2020/08/25/latest_news/1598382234_23093...
3. https://www.jsonline.com/story/news/local/2020/08/26/jacob-b...
Wim hof have achieved great things practising the ancient practice of pranayama which is actually a part of yoga. Yet he presents it as if he "discovered" it. This is pure intellectual dishonesty.

Yoga's actual name is ashtanga yoga which means it has eight limbs[1]. Contrary to popular belief Yoga is not about just twisting your body into weird poses. That aspect is called ASANA and what Wim Hof claims as his discovery is called pranayama which is a fully developed science of breath control practices by Sadhus and monks for centuries.

YAMA – Moral disciplines

NIYAMA – Positive duties

ASANA – Posture

PRANAYAMA – Breathing techniques

PRATYAHARA – Control over senses

DHARANA – Focused concentration

DHYANA – Meditative absorption

SAMADHI – Enlightenment

I think there is strong bias going on here in the comments. Two of the comments mentioning yogic origins of this practice are dead. So I present 2 videos as an example. First video[2] was captured by Indian soldier in -45 degree temperatures of himalayan border. Second video[3] captures another sadhu who lives naked under snow without any protective gears

[1] https://en.wikipedia.org/wiki/Ashtanga_(eight_limbs_of_yoga)

[1] https://youtu.be/8Xbi4Qrf9mE

[2] https://youtu.be/FcUdEkPa-2c

EDIT: Second video added.

EDIT 2: Major edit explaining yogic origins of this practice.
>Node.JS runtime (more or less full) is coming;
A Great Old-Timey Game-Programming Hack