skysight-inc/HackerNews huggingface dataset:
Are there general strategies for adapting drugs to click-chemistry or is there something special about doxil that makes it amenable to this approach?

To me it seems like one upside of using a well known chemo agent is that the oncology community is going to be familiar with it and possibly more receptive to adopting it into their practice. Probably will help with the approval process too.

Is the delivery method a major aspect of the trial? Could the biopolymer be adjusted to also provide embolization and/or doped on some of the materials used for Y90/SIRSphere type targeted radiotherapy?

This really seems like a cool idea, I wish you and your team the best!
Amazing people still try to have a discussion here. HN mods and users clearly do not believe in anything that approaches free speech or open debate.

Ideas here are ignored, down voted, flagged, shadow banned if they question the left ideology.
GP ignored that the argument was about the environment and straw-manned it into being an obsession with efficiency/productivity instead of life enjoyment.
> For the “common cold” vaccine, you’re looking at hundreds of strains across about nine types of virus, so a pretty tall order using traditional approaches.

A couple of hundred does seems tall at all, especially when it is basically just 9 different types. It seems to me that this is easy to scale once a general approach is found.

But since there is basically no progress on the common cold, I assume it is just not solved for any of these families, so the total number of strains or families doesnt matter anyway. Or it is mutating faster than we do anything. But I dont get how a small number like couple of hundred should matter - at least from the technogical perspective.
Ashley McNamara – The Thing About Burnout
Not really. Swapping just the screen out on a Lenovo unit takes about 5 minutes with a screwdriver and spudger. It doesn't matter what screen you put in it really so I don't get this point. If they did a retina one that fits in the hole then it'd work.

I have done this numerous times on older Thinkpads to put 1080p IPS screens in.

On top of that the entire lid assembly is 500% less of a shit show than the MacBooks are (I have repaired several of them as well) for 2mm or so of extra thickness.
A friend recommended me to watch Ashley McNamara's talk. It's great to watch as I can imagine it would be relevant to many - with tips to prevent getting to a point where you're completely burnout. I try to do things in a way that is sustainable for the long run: the people I meet, how I exercise, how I read, where and how I work, my side-projects (e.g. this weekly). COVID-19 makes it extra hard.
The Apple II line was very long in the tooth by the middle of the 1990's, but they were still fairly common in schools simply due to their investment in hardware and educational software. There were also people who clung onto to the Apple II as their only computer into that time period. I doubt that many of those machines were ever taken online, and they would have done through via BBSes or Unix shell accounts if they did. The Internet (and the web specifically) is probably what marked the end of 8-bit computers out side of collectors.

That said, the experience was okay if you were fine with text only access. Email and Usenet were text only. Then, as with now, images contributed very little to the content of websites so that wasn't too bad either. JavaScript uptake was slow, possibly because compatibility was terrible, so that didn't present much of a problem. Frames and tables were problematic, since they were used a lot for visual presentation. (If anything, I would say that the modern use of CSS for layout makes things better for text mode browsing.) Of course, web development itself could be done from pretty much any computers since it was then a much simpler markup language and there was a lot less presentation related cruft.
Pick a case where you believe they created law, then cite the bill that they wrote.
Nice re-read!
I'd be interested in the thoughts of people involved in ad tech on this.
The article's points seem convincing, OTOH old and new accounts of how effective micro-targeting allegedly is come to mind. Since 2016, the public and media focused on political ads and social media in that regard. But back when Google became the highly profitable juggernaut it is today, the effectiveness of targeting seemed all the rage. Especially the search ads.
Has the perceived or measured value of targeted ads really plummeted? Or is it just market saturation? Also I imagine a lot of "targeted" ads might be targeted badly.
Daily reminder: new respitory diseases come and go, nobody usually cares.

What makes Covid different and what caused the shutdowns was when Lombardy alone had 450 deaths a day. No regular influenza could do that.

It's not as if we decided out of thin air the virus was dangerous.
VC Guide (Anonymous fund and investor partner reviews by founders)
Why do we need the term “disinformation?” Deeply suspicious of this word. Seems to let politicians ignore allegations without having to declare them as false.
> No. A Full HD replacement screen for a last year's Lenovo Thinkpad can be had for as little as $59 on Amazon

What are you saying no to? That's what I said - an old-style low-res Full HD screen is cheap and standard. A modern retina screen is not. That's why they're harder, and so more expensive, to replace.
Who is “heaping praise on google” here?
The overachievers can do that in less than a year.
Certain exceptions from the right of withdrawal should exist, both for distance and off-premises contracts. A right of withdrawal could be inappropriate for example given the nature of particular goods or services.

That is the case for example with wine supplied a long time after the conclusion of a contract of a speculative nature where the value is dependent on fluctuations in the market (‘vin en primeur’).

The right of withdrawal should neither apply to goods made to the consumer’s specifications or which are clearly personalised such as tailor-made curtains, nor to the supply of fuel, for example, which is a good, by nature inseparably mixed with other items after delivery.

The granting of a right of withdrawal to the consumer could also be inappropriate in the case of certain services where the conclusion of the contract implies the setting aside of capacity which, if a right of withdrawal were exercised, the trader may find difficult to fill. This would for example be the case where reservations are made at hotels or concerning holiday cottages or cultural or sporting events.

Regarding how much you can test out an item, for example underwear or in ear headphones can't be sent back.

Some consumers exercise their right of withdrawal after having used the goods to an extent more than necessary to establish the nature, characteristics and the functioning of the goods. In this case the consumer should not lose the right to withdraw but should be liable for any diminished value of the goods.

In order to establish the nature, characteristics and functioning of the goods, the consumer should only handle and inspect them in the same manner as he would be allowed to do in a shop.

For example, the consumer should only try on a garment and should not be allowed to wear it. Consequently, the consumer should handle and inspect the goods with due care during the withdrawal period.

The obligations of the consumer in the event of withdrawal should not discourage the consumer from exercising his right of withdrawal.

https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32...
Optical tracking and laser-induced mortality of insects during flight
Which is costed into every purchase, and is (only pay of) why we pay more for everything.
This is very similar to Mao imprisoning people for "threatening the revolution". The revolution is good when it serves them but not when it threatens their hold on power. They now want to ban free speech because it is against their power interests.
This is really a problem with the US banking system as a whole, the check-prevalent culture where people are still willing to deal with such ancient financial instruments, plus the US society where people live paycheck-to-paycheck.

When you do an ACH pull or a check deposit, it generally takes several days or even weeks for the transaction to clear. (But when you do an ACH push or Zelle, the transaction may be irreversible.)

Would you be OK if your bank waited a week or two until clearing the check? Or the banks getting rid of the whole idea of personal checks?
And 40% of the population getting a influenza vaccine yearly.
Are you into deep work? I made a website where you can track your sessions + data, would love to get your feedback.

trywinston.com
I was recently surprised to find that it's not even possible to search for C++ on Apple's developer docs. When you try to, it replaces C++ with C.

https://developer.apple.com/search/?q=c%2B%2B
I completely agree that checks are inherently insecure.

That said, getting rid of checks completely is a much harder social challenge than updating the UX to show the right status.

UX updates are a practical recommendation that a few engineers at a bank could actually implement
> If they did a retina one that fits in the hole then it'd work.

Do they do that?

That's the point. The Apple retina one is non-standard because it's more modern. That's why it's harder to replace. That's why it's more expensive to replace.

> I have done this numerous times on older Thinkpads to put 1080p IPS screens in.

Yes... I'm saying that's the easy one. The hard one is the modern retina MacBook.
I bought a computer with a certified check that was too large once, and eventually I did get the store to take it, and promise a refund from their central office. I think it was months later and I had to call them up to get my refund, but it did actually work out. That was in the 90s and of course I would never do it again. It clearly was a well known red flag even back then.
"The fastest SBC at CPU tasks priced below $100 is the Raspberry Pi."

The Odroid N2+ costs $79 and is over twice as fast as the Pi4.
The Khadas Vim3 costs $100 and is about 30-40% faster than the Pi4.

The number of SBC boards out there is becoming huge; although the PI price has dropped significantly wrt performance and features (especially RAM), there's a lot of comeptition, and it's growing.

https://hackerboards.com/spec-summaries/
https://all3dp.com/1/single-board-computer-raspberry-pi-alte...
I've been sorta keeping an eye on the space for a long time, because the dream for me would be to get the biggest iPad and have that be my full-time machine. Currently (well, pre-pandemic), my work laptop just moved from being docked on my desk at home to being docked on my desk at work. Sometimes I take it off the desk at home to watch Netflix or sit on the couch, but if you're doing anything memory-intensive, the battery dies pretty quickly. I'd much rather have the battery life and weight of an iPad, if I'm not losing too much functionality (obviously a huge caveat, and the reason why I haven't gone all-in on any of the cloud-based IDE options yet), and I'd also rather have most of my stuff in a cloud somewhere, so if I lose or break a computer, I don't lose all my stuff.
That's because anti-LGBT hate and its proponents have a plurality in opinion polling.
You like playing with numbers do not you? Covid becomes a very significant risk for people older than just 60, we are not talking about 80+.
If you like this you'd love the Animal Earth book by Ross Piper.

It's absolutely beautiful.

https://www.rosspiper.net/writing/animal-earth/
They acknowledge this specifically: https://polyformproject.org/what-is-polyform/
I use tmux to group shells by context, setting a shell variable that various things in my bashrc respond to. The biggest win is a separate bash history per context, so my commands related to project A don't get mixed up with my commands related to project B or my sysadmin commands or ...

It's very nice!
This logs as a warning, right? “Step produced errors even though tool exited successfully?”
Those checklist are now even more critical, have to run through them or not accept delivery.
If the language defines a way for you to ask the program for the computation graph in order to differentiate -- couldn't you add meta programming functions on top of that computation graph?

Seems to me like there's at least an argument that it should be possible grow diff programming into a general purpose meta programming system rather than use general purpose meta programming as implementation mechanism for differentiable programming ...
I moved a company off Linode a few years ago because of ongoing intermittent packet loss (think 93%) for subsets of our customers, they never were able to do anything about it and just pointed fingers at the ISPs, who of course I have no direct contact or relationship with. Wouldn’t recommend.
> money and status that earn you freedom and the ability to not give a fuck what people who you don't respect think about you

Please, help me understand.

It seems to me like not being bothered by what anybody thinks of you requires neither money nor status.

Not only that, obtaining or maintaining social status, by definition, involves other people thinking highly of you in one way or another. And it would seem like one would need to be keenly aware of that in order to climb that ladder.

I say this as somebody rather uninterested in their social status (what's the point of it?), who went from relative poverty to relative wealth and saw no difference in how much I care about either money or status. So, very much interested in understanding how this works for others. What am I missing?
Plugins are great until you crash your standup board because the “Recycle” plugin put stories somewhere you can’t see but also didn’t remove the story from the sprint, causing permission issues.

A lot of what makes Jira so broken is that it is way too flexible, and this flexibility has costs in terms of performance and stability. There’s a damn good reason why I used Chrome back in the XUL days for FF; because XUL FF was not performant or stable for me back then.
So it was easier to add an instruction in silicon to cater for an ill-designed programming language, than to change the language itself?

I mean, if float-to-integer performance is so critical, why was this not fixed a long time ago in the language? What am I missing?
Yes, this is a good point. Thanks!
I honestly found it quite scary to leave comments on HN these days. You have no idea whether it's going to get upvotes or get downvoted to oblivion. It's one of these feelings when you're speaking to a small child who can get a tantrum any time of the day :)
This. The other thing is property taxes, in my area they generally let you pay by modern methods but charge ridiculous fees, so a paper check is the only sensible method.
Yes. Retina MBP screen pop nearly cost me £450 a few years back. When the option was presented I bought a second hand Lenovo T470 for the same money and sold the broken MacBook Pro as is on ebay and took the kids out for a couple of days with the change.

How did I break the screen? Well I dropped it three inches onto my sofa. Yes that fragile if you get it at the right angle. No thanks!

I've had several thinkpads and nearly beaten them to death basically and they just keep going. I poured an entire cup of coffee in one a couple of years back and fell over with it while running and it had a cracked keyboard footprint which was replaced for £15 from ebay. It still worked fine when I sold it.
Anyone thinking about buying a Tesla needs to follow r/RealTesla for a month before pulling the trigger (unless they're worth perhaps more than 10x-20x the cost of the car).
The idea behind cloud services is that you pay someone to manage that.
Slovakia Is Acquiring 13M Rapid Antigen Tests
Similar. used to be happy RS customer 6 years ago, then everything just got more complicated and less stable. Now they are public should have the cash to avoid any major issues like this. Just no reason to use them with G Cloud, AWS, Digital Ocean (happy customer with them too plus AWS).
The ability to guess plausible meanings if great for comprehending the words, but for speaking them? I’ve guessed „Spoonen” instead of „Löffel”; “live”, “liver”, “love” translated as the equally homophonic „Leben“, „Leber“, „Liebe“; and Siri regularly fails to know if I am trying to say „höher“ or „Hure“ (only one of the latter words is even in Duolingo).
The problem is widespread around the world, and exists in different variations in different countries. And then even more variations if you're trying to transfer money internationally.

Part of that problem is the continued existence of insecure-by-design systems that should have been forcibly retired many years ago. Another part is that even where safer alternatives exist, as this very story unfortunately demonstrates, it's all too easy for an honest person to be misled about whether they are using one of them.

Both of these problems are directly attributable to the financial services industry, which continues to make a fortune from the status quo even as lives get ruined and businesses go under as a result of preventable crime. Sadly, I can't see this changing until someone in a national government grows enough of a spine to regulate the industry properly, by which I mean setting out a realistic timetable for fixing the problem and then imposing crippling fines on any banks and other professional actors that don't step up.
Central park is a weird example because it's absolutely huge and I can't imagine how it wouldn't be enough for any dog.
I think you can only do it once, so using it as a "rental" seems unlikely.

Given how excited I was for the Model 3, and how disillusioned I got after handling one for a few days when a client brought one in to have some equipment installed in it, I'd suspect it's some combination of quality issues and simply varying expectations. Tesla makes a LOT of decisions differently than other automakers, and there are plenty of people who love that, but also some who realize they're not comfortable with the car trying to outsmart them so often.

And that's the sort of thing that might not sink in on a 20-minute test drive, but which you'd definitely feel after a few days.
Stories like this are the reason for all the social disrancing measures and work from home. Not everybody can follow this of course. But those jobs that can be done from home should be done from home. And social distancing should be followed as much as possible. Sadly, people have to be forced to do so it seems.
What you need to look is not fatality rate, but total fatalities caused by the disease. Flu kills 60000 a year max in US, Covid kills 5x that number. And it is unclear what will be a fatality rate for younger people whose organs are damaged by previous infection.
I SSH into a VPS and use Vim as my development environment for most of my work.

It's good because that way I can work on web stuff on a similar environment than prod, I get all the linux goodies that come handy when developing backend programs, and I can work anywhere from a cheap netbook by tethering my phone data in the bus, with only a terminal console.

So far it work really well.
Why not? Why can we not require companies to design their products differently?

I'm sure car manufacturers would love to exclude all those pesky expensive safety features from their new cars, but they're not allowed to do that. We've required them to design parts of their product in specific ways.

Or how about airplanes? Boeing sure seems enthusiastic to get rid of safety features on their airplanes, should we really allow them to do so?

Or how about the phone you might have in your pocket? It talks to a cell tower right? We've restricted the designs of the radios in the phones and cell towers such that they don't emit more EM than a set limit. Surely Verizon could get much better coverage if they just crank up their signal, drowning out everyone else?

Point is, we regularly and consistently restrict how manufacturers can design, manufacture and eventually operate various goods. Why should Apple get a pass?
Shortcut for Cleaning Clipboard
As you may already know that many apps steal information from the clipboard. It's nice that Apple starts showing such spying activities.

So I decided to give more control of the clipboard situation and made a simple Shortcut that shows you what is in the clipboard and if you decide to clean it up Shortcut will do it for you.

Feel free to use it https://bit.ly/3lUeC2i
Double 0.5% is 1%. Where'd you get 50%?
Facebook deletes satire post claiming Dem Senator testing ACB as a witch
Great tool, super useful.

For a few extra bucks you can use a programmable temperature controller... search "Programmable Temperature Controller Ramp Soak Heat" at the usual suspects. Allows you to program heating ramp up, ramp down, and soak times - very useful for heat treating various alloys.
Canadian government invests in small nuclear reactors to help meet net-zero 2050
There's complications in ..every..single...disease.

People have died of papercut complications..

What if 'long covid' is some underlying pre-existing pathology that ANY disease could trigger.

So the question becomes are these statistically likely complications and is this directly from the covid virus.

The media is feeding you fear about 'long covid' and 'covid toes' and 'covid reinfection' and all of the other sensationalized things about Covid that people eat up like Jerry Springer.

Covid-19 and all of it's viral siblings are all solidly respiratory viruses.

Anything else you hear is speculative fear based over hyped statistically unlikely complications with unproven conclusions.

This whole pandemic is fed off of people who are just fundamentally bad at statistics and interpret every reported sensationalized account as an likely possibility and trust that the news media is unbiased, agenda less, and faithful to the truth.

Also...bgr.com is a news outlet not a science source. They make money off of fear. Do you well to look at data and think for yourself.
I've got dual monitors on a Mac Mini. The primary monitor uses the HDMI port, and it works fine. The secondary monitor runs off Thunderbolt and a couple of weeks ago it started going black, randomly. This isn't a hardware issue, because I have used multiple cables and monitors, and I have used both Thunderbolt-to-HDMI and Thunderbolt-to-VGA adapters and I get the same issue. Oddly, the black screen still shows the mouse pointer, and if I take a screen shot it shows what the monitor should be displaying.

The fact that it just started happening leads me to believe that it came with an operating system update, and it's probably a driver issue.

Apple really needs to get its act together on USB.
Liberals fought against the Hays Code. And now they condone Twitter and Facebook on the same premise as those who defended the Hays Code: that its private actors voluntarily policing speech that’s harmful to society.
Once the tech is there, working, viable, EU will start a gradual move towards tax optimisation to include the externalities and level the playing field.
Another consequence of almost all Esperanto speakers having learned the language later in life and without spending a lot of time using it, is that a beginner is less likely to get negative feedback like "Lau Zamenhof cu estas malbona frazon." when they make a mistake like translating from their mother tongue too literally. The other person might just blame their lack of understanding on their own limited command of the language.
When you start thinking of everybody in a group of thousands as one person, it's a mental health red flag IMO. Quite common, but suggests taking a break.