skysight-inc/HackerNews huggingface dataset:
https://m.youtube.com/watch?v=D9JCwkx558o

I save myself time by watching YouTube videos about philosophers instead of reading the primary sources

In the end, I’m able to take a broader survey and dive into what I actually care about

Ultimately it isn’t any of the philosophers

I see nothing wrong with reading primary sources though

Just not for me
Or, you know, he should just get a prescription?
I've been trying out jobs like I've been dating and it's been terrible
>So a dev can be working on a feature over an open ended number of sprints

Sure. Ideally it would be broken up into tickets that fit inside individual sprints, but sometimes particularly hard problems are just going to roll over. That's fine and nobody should feel bad about it.

I hated agile the first time I met it because the team had no autonomy and a bad culture. When you actually have the ability to treat your process like a tool, none of this is a silver bullet, but it's a fine tool.
Twitter is bringing its ‘read before you retweet’ prompt to all users
Some services may require gigabytes of state to be downloaded to work with acceptable latency on local decisions, and that state is replicated in a way that is constantly updated. These could include ML models, large routing tables, or anything of the kind. Connections could be expected to be active for many minutes at a time (not everything is a web server serving short HTTP requests that are easy to resume), and so on.

Changing the instance means having to re-transfer all of the data and re-establish all of that state, on all of the nodes. You could easily see draining of connections take 15-20 minutes, and booting back and scaling up to be taking 15-20 minutes as well, if you can do it for _all_ the instances at once (which may not be a guarantee, and you could need to stagger things to be more cost-effective).

You start with each deploy taking easily over an hour. If you deploy 2-3 times a day and that your peak times line up with these, you can more than double your operating cost just to deploy, and that can take more than 4 figures to count.

Some of the systems we maintained (not those we necessarily live deployed to, but still required rolling restarts) required over 5,000 instances and could not just be doubled in size without running into limits in specific regions for given instance types.

If a blue/green deploy takes a couple minutes, you're probably not having a workload where this is worth thinking about that much.
Most neolithic sites are basically grassy mounds. They're everywhere, both in Europe and North America.
I think as we’ve learned more about the virus we’ve learned (after the occurrence of the initial BLM protests) that the transmission rate in large open environments such as beaches or some protests is signficicantly lower compared to closed environments such as churches. In hindsight this does make it hypocritical that some events were criticized and others were not, though the argument can be made that given information at the time the prevailing notion that outdoor rallies by a demographic that refuses to wear mask (for example, in tight knit admissions lines at said rallies) would undeniably spread a not insignificant amount of COVID.

Ultimately as a hypocrisy it’s small frys compared to the tidal wave of misinformation and intentionally damaging information, as well as the incompetent response and outright pitting of states against each other, compared to the current administrators actions during COVID as a whole.

TLDR; America’s response to COVID has been a relentless failure compared to all other western countries of similar size and demographics (outside of MAYBE Brazil) such that exaggeration and hypocrisy towards a small number of social gatherings is utterly insignificant by comparison.
QAnon and the Emergence of the Unreal
>What about the millions of idiots and non idiots who die due to lack of medication?

Is that because of lack of money (to see doctor, get prescription, buy drugs) or because of mandatory prescription alone?

Because in civilized countries nobody dies "due to lack of medication" just because a prescription is required.

Except if you mean people can't self-expirement with their own arbitrary self-prescriptions, and die from that because their doctors wouldn't prescribe them the same stuff.

Which is an argument I don't really understand -- is the premise that people informed by the self-study/internet/drug ads/friends/fake news/whatever, know better than a qualified doctor what to prescribe themselves? And that these competent self-prescribers abound so much, that are more in number than the people who would just fuck themselves with BS self-prescriptions?
Fantasque-sans used to be my favorite for monospaced font - still like it a lot. Now a days, I use Fira Code which also looks quite good.
The full context of the Wilson Newton/Darwin quote, from an obscure lecture (Worldcat has no record), is this:

The trouble with the theory is that government is not a machine, but a living thing. It falls, not under the theory of the universe, but under the theory of organic life. It is accountable to Darwin, not to Newton. It is modified by its environment, necessitated by its tasks, shaped to its functions by the sheer pressure of life. No living thing can have its organs offset against each other as checks, and live. On the contrary, its life is dependent upon their quick cooperation, their ready response to the commands of instinct or intelligence, their amicable community of purpose. Government is not a body of blind forces; it is a body of men, with highly differentiated functions, no doubt, in our modern day of specialization, but with a common task and purpose. Their cooperation is indispensable, their warfare fatal. There can be no successful government without leadership or without the intimate, almost instinctive, coordination of the organs of life and action (pp. 56-57).

Original: http://www.garynorth.com/public/12711.cfm

https://www.loc.gov/item/08017752/
And importantly - why? Where does the risk/reward chart get so skewed that wearing a piece of cloth that can only barely be considered uncomfortable become an option that's unthinkable? It seems entirely plausible that it could help, what is the harm in trying it? It takes a lot of mental twisting to end up in a place where the potential risk of wearing a mask is larger than the potential reward.
But when drug discovery is a 4-6 year endeavor, knowing your site-of-action better and starting from a well-characterized template is worth its weight in gold.

Edit: I realize this might not be clear, but drug discovery is a separate paradigm from drug development. So, together they take around 10-13 years.
I think he completely shut down any respectful discussion with the Debian maintainer. It's not just discussion with the requests from users where I think he was rude, though I can understand his position more, but his attitude to the Debian maintainer is unfortunate
I don't know whether this is true, but I think that the freak out and measures are grossly disproportionate compared to the danger of the virus.
The US has social safety nets.
> Prineas in 2001 showed that MS progression may occur in the absence of immune cells and inflammation

MS researcher here. MS as an autoimmune attack is largely settled in mainstream neuroscience. The paper you cited does not show what you said it does.
From the paper:
> restricted largely to short segments of disrupted myelin located within linear aggregates of microglial cells

The paper is interesting because it shows that demyelination is happening in lesions that we thought were inactive, but actually do contain microglia and macrophages (immune cells) eating myelin (i.e. an autoimmune --immune system attacking self-- attack). The paper is paywalled but I but you can read it on sci-hub (https://sci-hub.scihubtw.tw/10.1002/ana.1255) Although just reading the abstract says the opposite of what you are claiming, the entire thing is about microglia and macrophages contributing to lesions that the researchers thought were inactive.
Somebody posted in response to your original post that it took them 30 seconds to find this: https://www.nature.com/articles/s41591-020-0843-2

Does it influence your position on whether or not masks are useful?
Show HN: iOS 14 Icons Kit (Figma and PNG)
Basically the default configuration on each is different, and some have different features.

On macOS there is little or no hinting, the result is less contrast and, at smaller text sizes on standard-resolution displays, eye strain; the upshot is that the shape of the fonts is generally more faithful, of course, macOS undermines this by completely changing the weight of fonts when you enable subpixel antialiasing (which is why there's CSS all over the internet turning that off).

On FreeType2 w/ Pango/Skia/etc (Linux/BSD/Android/iOS), the subpixel rendering actually works properly and doesn't change the weight of the font, and on the horizontal axis the hinting is mild or completely off, and the vertical hinting is less mild or quite aggressive. Most FreeType2-based renderers now position glyphs on thirds of a pixel, when the display can supports that. I personally prefer the default fontconfig on Arch Linux over every other text renderer.

Windows has ClearType, it is by far the sharpest text of the bunch, and at standard text sizes that can make it very legible. The tradeoff is that it completely mangles the shape of fonts, and the result only vaguely resembles it; furthermore there is such a thing as too much contrast and I find that ClearType can feel harsh and causes me a form of... aesthetic fatigue?

Overall it seems that there is a whole spectrum of ruthless efficiency vs. aesthetic considerations. I don't think there is a universal scientific answer to these questions.

Of course, once you have 3x standard resolution displays it doesn't much matter as long as you aren't mangling the fonts some other way, at some point you don't even need to antialias.
Deep Learning for Programmers book with new chapter Tensor-based neural networks
So now that several other posters have given you several different links, are you modifying your stance at all? If not, why not?
For domestic Chinese internet users who are inside the great firewall, the authorities intend for people to use this instead, which is censored.

https://en.wikipedia.org/wiki/Baidu_Baike

https://en.wikipedia.org/wiki/Baike.com
> This website has a horrible, no good, very bad layout and is difficult to read

- loads immediately

- font size that's readable when zooming to fit the paragraphs width to the screen of phone

- no auto playing video

- no various modals popping up

- no need to click extra things to expand texts

I have no idea what you're talking about, this is one of the more readable websites on my phone
Is This Real Life?
So I work at Oracle, but as an engineer. These are of course my own thoughts and I’m not representing OCI.

As far as I know, there’s no difference between any of the clouds as far as basic payment structure. If you don’t want to be locked in on a contract, you just give a credit card and pay the publicly posted rate. Exactly how are you a hostage in that position?
How does their DRM improve typography?
There's also the FL/OSS BSD's, although I don't know how viable they are for desktops outside of ThinkPad's.
https://www.latimes.com/archives/la-xpm-1996-07-09-mn-22423-...

He later publicly thanked US for helping him win.
i love learning with scrimba. when they first introduced monthy subscription, I enrolled without thinking twice. Been following per before scrimba days from his medium posts. They have recently improved UI so much. I'm half way through the program. hope to do my entire coding learing via scrimba in the coming years, like both frontend and backend.
My #3 point, in case it wasn’t clear, is this: any particular form of libertarianism, in comparison with many other political philosophies (such as as the platform of progressives in/near the Democratic Party, has considerably fewer principles that must be traded off. Libertarianism is widely regarded as ‘intellectually simpler’.

My #3B point emphasizes this question: ‘Is simplicity best? Or simply the easiest?’ (to quote a song)

In my view, the respectability of private mortalities is not strongly correlated with the simplicity of their core principles. (For background on what I mean by public and private moralities, see writings by Robert Kane, such as ‘Through the Moral Maze’)
Umm, I believe the US government is in the process of demonstrating that they are indeed above the law.

Unless the judge and court in this instance reverse course completely, throw out most of the last two weeks as political maneuvering, and restart a fair and publicly accessible hearing, that is exactly what's happening.
To me, following modern MS research progress is as exciting of an inward journey as space exploration is an outwards one. In fact to the point where I have considered leaving the tech field within the next 5-10 years to partake in it so it's fun to see this here on HN.

Just 20 years ago the first disease modification treatments were introduced. These were recurring injections of interferon-beta (1b/1a) for a 18-38% reduction in relapses and annual relapse rate (ARR) of 0.256[1]. Today there are about 20 different options, with Rituximab and humanized variants indicating an annual relapse rate of 0.044 for RRMS patients with a well understood safety profile[2]. On such medications an MS patient can expect a relapse every 22 years vs every 2.5 years unmedicated.

My pet theory is that MS research will ultimately lead to significant breakthroughs in longevity research. This is based on the morbid view that the disease is serious enough for risks to be taken in understanding auto-immune responses, crossing the blood brain barrier and remyelination.

[1] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5474703/

[2] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5109942/
>” The simple fact is that enough happened in enough location..”

But why with the backdrop of that violence do they characterize that one “as mostly peaceful”. They could at least have been forthcoming and said while most are peaceful this one has devolved into violence you see behind me. But they are like Baghdad Bob ignoring the bombs falling as he broadcasts...
I think there's a three-pronged cause for reduced trust in public institutions in the US.

The first problem is that US governing elites have proven themselves to be corrupt and untrustworthy.

People in the tech sector have not been greatly exposed to this, but wages for the median person have remained stagnant for the past four decades. The elite response has been either to deny the problem or make it worse. People do notice when it gets harder to make ends meet, and the failure to address this problem has undermined faith in the elected arms of government.

Other issues such as the bipartisan consensus to invade Iraq on the basis of fabricated evidence and the fact that Trump has told 20,000 lies about objective matters since assuming office have exacerbated the problem.

The second problem is that conservatives--including conservative media--massively overstate the scope of governance problems in the unelected civil service as an electoral strategy. These viewpoints are amplified by Facebook and other social media in search of engagement.

The third problem is low quality education among the bulk of the population. Critical thinking skills are not effectively taught, much less internalized, by the average person. Most people are not able to effectively evaluate information they are given, which leaves them vulnerable to whatever propaganda Facebook et el shovels into their feed.
I'm confused about why Bexarotene can be sold as Targretin to treat "skin problems"[1], but cannot be used as a potentially life-saving treatment for MS.

Is it that the dosages must be higher to treat MS?

[1] https://www.webmd.com/drugs/2/drug-17979/targretin-oral/deta...
https://tldp.org has many good resources
For a second I thought this was the KiTTY Telnet/SSH client [1], but it appears to be an unrelated piece of software.

[1] http://www.9bis.net/kitty/#!index.md
> Participants were recruited year-round from March 2013 through May 2016

The study you linked did not have any covid patients.
Both of those things were investigated and shown to not be a silver bullet and I think HCQ actually is harmful. The problem is Trump doubled down rather than simply informing us that the latest research had recently shown otherwise. Their need to calm people is influencing what they say.
> My dictionary defines “espionage” as “the practice of spying or of using spies, typically by governments to obtain political and military information”. A spy is defined as someone who “secretly obtains information on an enemy or competitor”.

Im glad this blog acquitted Assange of spying based on technicalities in his dictionary's definition of espionage. I think Assange did a great thing for the world, but it also sounds like he actively facilitated spying
I think it’s because we slowly devalued the authority of expertise and knowledge, because conflict generates more views.

Even in respected media, journalists try to angle stories from opposite sides. So you’ll have a random person from Facebook take up as much screen time, if not more, as a literal PHD in infective diseases.

It gets worse over time, as the story gets more and more boring. I mean, it basically hasn’t changed in 8 months, but you can’t just re-run information in modern media. So you’ll have days where the top corona virus story is about some social media person getting banned from Instagram for spreading fake news, and not how the amount of infected is exploding in Europe again. I mean, that bit did pick up in the following days, but why was it ever news that some idiot got banned from Instagram?
> Try asking anyone not in the top 5% of the worlds wealth if a gaming console and a smart phone are of comparable importance. Then, ask them if smartphones and consoles should be afforded similar consideration and protections by their society.

You're not directly addressing the argument. Literally nobody here suggested that they are of comparable importance. Everyone concedes that smartphones are far more "important" than gaming consoles. The argument is that the "importance" of smartphones today is an ephemeral condition. You yourself agreed that basing policy on ephemeral trends is probably not a good idea, so the best way for you to stay internally consistent is to prove that this is somehow not an ephemeral norm.

> The rest of your argument, seems to be that "the market will sort it out" and any interference with the space will stifle growth and innovation. Maybe. But I'm sorry, that's not a universal "first principle", that's an opinion. My opinion is that smart legislation could actually accelerate growth and innovation while at the same time enhancing user freedoms and protections. But that's getting off track and wasn't the point I was making:

No, the central argument is that the current reality has only been true for < 10 years. That's not an opinion, that's an observation of history. And the definition of "user freedom" is blurry here, because some of us enjoy the freedom to use a tightly controlled operating system for our own convenience, and see the desire to break that up as a violation of our original choice. You might have a good point to make if consumers originally expected to have some level of control over their Apple phones, but people explicitly signed up for the opposite of that — we've always known that the walled garden was a part of the deal. You might also have a good point to make here if there was no alternative in the market, but just like PC's and Consoles, there is a more than acceptable alternative that's conveniently also cheaper and more within reach for the "non-5%". The entirety of the worlds knowledge, the ability to communicate with anyone in the world, and the deeply intimate thoughts / ideas are equally accessible on both platforms, and switching between the two is fairly straightforward considering most major services are provided on both platforms, and the credentials you would use to access your bank account or your medical records or your email work on both types of apps.

> Equating smartphones with gaming consoles is as intellectually lazy as it is troubling.

Again, you're really not addressing the central argument, and you're relying on insults to make your point. The central argument is that while there is undeniably an "importance gap" between the two, we ought to apply the same principles because the gap is ephemeral. If you really believe that the current norms are NOT ephemeral, make that case, you might even have a good point. But you don't need to attack the people making the argument, which undermines your case (and yes, calling an argument "lazy" and "ridiculous" and "troubling" is just a thinly veiled attack on the person).
I make no value proposition on his work, knowledge or the extents of his role. I simply quoted the role he mentioned in the link, which makes no mention of his other contributions to Arch.

Regardless, I find his tone and attitude quite condescending to the Debian maintainer.
The Oxford Questions on the foundations of quantum mechanics
New Improved Music Identifier Will Help Creators in All-Important Digital Market
Lucidql: A GraphQL Generator
Yep, architecture decision records (ADRs) for the win. Just next to your README file in the repo.

But big projects seldom use rebase. This is because it's quite hard to `git revert` an entire change from two weeks before (change being e.g. 50 related commits).
if only they hadn't reasons to believe them
You probably know that plate tectonics was considered "pseudoscientific crankery", do you?
I was warned about upgrading to Catalina and held out for almost a year. Too long it seems. Since upgrading, I think I have got five or six popups asking if process X is allowed to read directory Y. And I am a power user with tons of brew packages, developer tools and utility apps. I think Apple is keeping a good balance between convenience and security.
Second this! flutter would be amazing to learn in scrimba
This is exactly what I was looking for https://crowdfightcovid19.org/volunteers/
> U.S. Centers for Disease Control and Prevention, or CDC, are exaggerating the danger posed by the virus in order to damage Donald Trump’s presidency, which increased to 32% in July;

It's not a conspiracy to suggest that people are exaggerating the danger posed by the virus. There are many factions, political and otherwise, that have a vested interest to do so, particularly in an election year. To file any exaggeration in the danger of covid as conspiracy is exactly what makes people disbelieve more legitimate science sources.
I think many people look at that logic (that those large BLM protests were safe) and wonder why it can't be applied to more mundane activities such as the US Open.

It comes across as blatantly partisan and not the least bit driven by the science.
How the disease hits is widely different and this generalization is incorrect - it might get some sufferers correct, but far from all.

Source: friends with very normal lives
You’ve overtrained your neural nets on technology.

Please update your training set by reading more generally.
Here's how to install more default font replacements on Fedora: https://github.com/silenc3r/fedora-better-fonts

Would be great if Linux distributions provided similar expanded font setup out of the box.
It's not about specialized knowledge...it's about regular maintenance.

Hate me or not...but people can't be trusted (broadly) to maintain things...thats just the way life works.