skysight-inc/HackerNews huggingface dataset:
The explanation in the article is sort of along those lines, if cancer cells' inability to switch to a protective state is due to their faulty programming always keeping them in a growth mode:

"Essentially, fasting causes a switch in healthy cells from a proliferative state towards a maintenance and repair state. Malignant cells, in contrast, seem to be unable to enter this protective state because of oncoprotein activity, and therefore fail to adapt to nutrient scarce conditions. Instead, fasting deprives proliferating cancer cells of nutrients, growth and other factors, which renders them more sensitive to cancer therapy and increases cell death"
Previously discussed here:

https://news.ycombinator.com/item?id=24474830 (157 points | 48 comments)
Could you explain why you left ProtonMail?
Done here: https://gathering.tweakers.net/forum/list_message/63774530#6...

Discussion there is in Dutch but I clarified that English is needed for participation in the study.

I hope your post will also get more traction here.
@systemvoltage: “I often wonder what if we decide to build a completely new, well thought out computing system (including network) that is totally separate from any legacy system and 100% backwards incompatible.”

Good idea, and then run legacy apps under an emulator. Each instance created and destroyed after use. That way there will be virtually no chance of malware propagating through the system.
You can use "enye" as a placeholder for "eñe".

On the location, currently is right to "l", in the US

layout it prints ";".
There are a lot of companies developing river turbines that possible could complement this well. I have no idea if they produce the right amount of power though.
How 'Cuties' Is Fueling the Far Right's Obsession with Pedophilia
I've been working on a workshop workbench, also using 20 series aluminum extrusion. Here's a picture of 2 of the 4 pieces: https://photos.app.goo.gl/AMaBwa5pRBQfqDPQ7

Aluminum extrusion is pretty nice to work with, though in retrospect I probably wouldn't do it again for the workbench. I was able to source it from China via Alibaba, and even with $200 shipping the pricing is way less than you can get it in the US. It was so inexpensive that I ordered a bunch extra in case I want to build a custom 3D printer or CNC or something. The extra was nearly free.

You can cut aluminum on woodworking tools. I went slow, and the cuts I got looked nearly as good as the factory cuts. They are quite sturdy.

My idea was that I could use the extrusion channels for mounting accessories or clamping. For example, mounting rollers when using it as an in/out feed table. A jig for flattening some raw wood using a router. Channels to lock the 4 into a 4x8 assembly table, but split it apart to store along the back and sides of the garage.
I think the best solution to avoid plastic pollution is to tax it heavily where it does not make sense, whether it's single use or not.

Also I believe a nice solution to plastic recycling would be for legislators to implement a standardisation of all the bottles / food packaging / etc. so that they all use the exact same type of plastic.

Then once we stop dropping tons or plastic on our ocean and polluting our soils with it, we might end up with a quite-clean environment in the next 50-70y (and pray that there are no long term effects on plastic contamination).

But in the end, the best solution to plastic is definitely to stop using it.
A well articulated and helpful comment. Can I ask which FAANG you work(ed) at?
csearch/cindex has not changed for 5 years, pretty useful and reliable
https://github.com/google/codesearch

cscope: last version in 2012, combined with Vim
http://cscope.sourceforge.net/

[edit] actually codesearch received 2 fixes in 2018
It’s not “orders of magnitude worse than a bad flu season” precisely because the entire country shut down for months
My wife is Stage 3, ++- (43 yo) and half way through the taxol phase of an ACT regimen; she is progressing well but I know she has the discipline to do a fasting diet if we thought it would help. Any thoughts on starting this mid-way through the treatment?
How does it compare or complement the "river cleaner" from the Ocean Cleanup?
Why the stability of the 2020 race promises more volatility ahead
An Introduction to Container Orchestration
Source? What makes combustion particulates from coal substantially worse than combustion particulates from wood?
This assumes we know what schools are for. :(
Privacy is a social norm; it happens to have some not-exactly-matching instantiations in law. Mistaking the two is dangerous.
Uh no not at all. I don't have an opinion on the issues I mentioned. I just think that if you put an issue into a category and use that as the basis of your explanation then your argument should also hold for all elements of that category. For example, if you ask me, why do I like trees and I say, because they are green, then it would be logical for you to ask if I like green apples and green cars because they are also green. If my explanation was valid, then I should also like green apples and green cars.

The point is there are many many many theories out there for which we have limited evidence for. Given that, it doesn't seem to be enough to explain why right wing folks latch on to certain of those theories but not others.
A couple observations (as someone who who doesn't really follow Assange but stumbled upon this article):

- In the UK, publishing the transcript of a public hearing is a crime - "NB this is not a precise transcript. It would be illegal for me to publish a transcript (of a “public” court hearing; fascinating but true)." - IMO something is deeply broken with this, needs to be changed and potentially people who created this system need to be punished (for taking steps to undermine democracy).

- Publishing evidence of (war) crimes (this is what Assange did, right?) somehow appears to be a crime. What happened to failure to report a crime? Shouldn't instead people not publishing this be punished?

- A video call is too high tech for the UK government; also moving to a different courtroom where it would work is impossible because they'd have to carry over too much paper. They do everything on paper - linking to some other piece of paper means making a physical copy - "Are you saying that I should have repeated his affidavits and all the other evidence in my statements? My statements would have been thousands of pages long." - Hello, we have the internet and hyperlinks, can we pls use them? To me this feels like the courts are designed as a DoS attack on people's attention.

- Some US prisons are designed as death penalty without having to go through the legal trouble of saying it out loud - "Suicides in jail are increasing by 18% a year."

- Assange seems like a political prisoner - "Eric Lewis than gave testimony on the change of policy towards prosecuting Assange from the Trump administration." - Why does a president have this power? What happened to the 3 branches of government? Maybe this is a US thing, seems very broken.

- It's not even a public process, except in name - "Public access continues to be restricted and major NGOs, including Amnesty, PEN and Reporters Without Borders, continue to be excluded both physically and from watching online." - Why is everything not recorded and at least transcript posted online by default?
A 256 bit number is 2^256 possible combinations. 8^256 is the same as (2^3)^256 (or 2^768)
Distill: Transcend, a Primer on How to Liver Longer and Better
Interesting, this claims that fish and other wildlife can pass through but they don't seem to explain how it's different from bubble barriers used to deter fish from passing into underwater construction zones related to drilling or pile driving [1].

[1] https://www.newnybridge.com/protecting-underwater-wildlife-b...
“Performance Matters” by Emery Berger (2019)
And to connect the dots, the smaller brush will return every year. So there's really no meaningful limit here; it can be this bad or worse every year to come.
Here's one such app, for people that are interested: https://shootismoke.app

It's currently giving me 2.3 cigarettes per day, and I live a decent distance away from any of the fires (Sacramento, CA).
Makes me wonder about the Spectravideo (Z80 based) machines.

Some had 16 kbyte RAM. All Spectravideo had also 16 video RAM. But the version with 64 kbyte RAM was prominently marketed as having 80 kbyte RAM. (RAM + VRAM = 80 kbyte)

I guess that computer model could also have been imported without the high tariff.

(The Spectravideo 328, which formed the basis for the almost identical MSX standard.)
I'm actively looking for better sources.

Honestly, one of my biggest problems with Cliff isn't even a new one ... his blog is almost wholly one-way.

He spent all this time to build a platform, but doesn't seem to care about his community at all. Doesn't respond to smart comments, nor dumb ones. Not on busy popular posts, nor quiet ones. Doesn't answer questions at all really.
Server side tracking would mean that ad companies don't have access to cookies + user fingerprints, so they would be less effective at serving targeted ads.
Maybe you are correct and it is iPads then and not iPhone or macbooks. But all the latest usb 3 cables from Apple are charge only.
I think that as long as you tell AWS that you have a process to handle the bounces, it's not a big issue. This is where my guide is handful. Getting information on the bounces is part of the way to handle them correctly!
CISA: Chinese state hackers are exploiting F5, Citrix, Pulse Secure, Exchange
Wargames! The writers for Sneakers, Lasker and Parkes, first encountered the ideas they used in Sneakers while doing their research for Wargames, and apparently generated a good deal of the plot for it in '81.
They figure they can make more than $40B by driving ARM to the ground?

Personally I don't think that's true in this particular case, but the strategy isn't exactly unheard of.
This made getting started with emacs so easy for me, long ago now! Thanks and congratulations!!
Thank you for looking into it. I will consider removing it from my account... seems to only add barriers that are vendor lock in and not actual security.
Just a guess, but it's probably because the finger-joint boards are made from short offcuts from the manufacture of larger boards like 2x4s joined together with long zigzag joints. Saw kerfs and finishing sanding probably account for the ⅛" difference in size.

It's usually not a problem, except when it's used beside a 2x4 on the flat, in which case the 2x4 needs to be thinned down on the table saw.
Free software is immoral. It changes programming into slavery.

See? I can make simplistic moral equivalencies just like Richard Stallmab.
Egyptian here, can confirm this unfortunately. Most here just go all-in when they break their fast. In fact, I would say that they ingest more calories in Ramadan than in regular days. I advise all I know to eat with moderation, but few listen :(

Personally, when I started to eat moderately when fasting, I started to feel much better. Previously, I would be very tired when breaking the fast... I would be so full that I wouldn't be able to do anything except lie down.

I think that the current trends are due to people nowadays seeing it like a mega celebration, and they see that eating a lot and feeling tired after is just a sign of that celebration.
Ramadan is more than just fasting, but I am going off-topic.

By the way, there's a sunnah in Islam to fast Monday's and Thursday's. Some here may find it beneficial.
I am imagining an industry where half of developers don't know how to design a relational data model. Scary if true.
I haven't looked at the Shorts feature, but I think the fact that both Reels and Shorts are being integrated into bigger, well-established interfaces will make a big difference (quite possibly negative).

TikTok is just TikToks. Reels have to fight for positioning in an overall sea of Instagram features and Shorts will do the same. YouTube and Instagram have different focuses, though, and I think that could make a huge difference in the uptake.

So my point is "they're sitting in different user experiences", which is why they'll fare differently. I just can't predict which will do better!
Well, if the deal goes through, the owner will be a US company...

As I said, I don't have interest in the deal, just the satire didn't convince me.
> variant of TLS 1.2 that most people have deprecated long ago.

I agree with most of your post, but not this part. 1.2 is still out there on a large number of sites, but even worse 1.0 and 1.1 are there on many of the most popular sites. Google.com for example, despite all major browsers now having deprecated 1.0 and 1.1.
Well in my case I prefer prelude because it seems like what it really is: a curated set of Emacs settings and configurations.

Doom or Spacemacs really transmogrify Emacs into VSCode or whatnot -- I feel like I'm losing control of my Emacs config as they have layers and layers of elisp.
I love Prelude and have been using it for several years. Thanks for all you do!
Case in point, India: https://www.youtube.com/watch?v=XeDY3I841q0
I fully agree - that can be very tricky indeed.

But I think your response on VIM does add another great point to this discussion: nobody would have considered VIM incomplete for not having JSON support, before JSON even existed. In theory, VIM could have been complete AND finished earlier without JSON-support, back in the day before JSON.

But then JSON happened - and suddenly VIM suddenly no longer had a complete set of core features. And not being complete means not being finished - since being complete is pre-requisite for being finished. And doesn't that mean, that a piece of software which does NOT get new features, can't stay "finished" when things change and new requirements emerge? Doesn't a piece of software have to get new features so it can stay (close to) finished - and doesn't revert back to being incomplete?

The only way a piece of software could ever stay "finished" without getting new features is, if it was used for something that no longer sees any change happen or any new requirements emerge - it basically has to be a completely non-evolving field of work with static, unchanging requirements. But any active, evolving field of work will always see changes and new stuff and subsequently new requirements will emerge. Software has to react to those changes in requirements.
Coal can have radioactive materials inside of it. There's radioactive carbon (c14) and it looks like also a bunch of more concerning materials.

[] - https://www.scientificamerican.com/article/coal-ash-is-more-....
I think his point is that the average scraper isn't going to bother simulating mouse movements to trigger the hover behavior.
Very cool landing page!

I am a bit confused by the conflict terms: "text editor" and "no code". Doesn't "no code" imply that you don't have to write any text/code?
Nvidia's soaring shares make $40B ARM buy easier to digest
Ctrl-f also returns no results for Lent. I haven't tried for other religious fasting or abstinent holidays but I'm sure there would be 0 to few mentions. HN skews strongly towards certain industries and demographics so it's a bad sample of "the western world" and it seems that most people posting here would simply lump Ramadan under "religious practices" of which there are several mentions. Most religions include both feasting and fasting practices so I wouldn't single out any single one as more healthy or hurtful for the world.

I agree with the basic premise that religious fasting is an often overlooked but beneficial practice in the modern era.
I can’t really feel bad for the Viners. I sympathize with the idea that Twitter is/was mooching off free content, but at the same time: One should never make content with the expectation of getting paid, and then post on a free website that doesn’t pay anyone.
If Netlify is completely static I could see there being a single server being the master copy and every edge server being just a caching proxy in front of that.
But they eat each day in Ramadan (at certain times), don't they? How is it even "fasting" and why should it be mentioned?
Like it or not, 90% of the web relies on JS for it's UI to function properly.
http://archive.is/gMev6
>First of all, one common statistic is that 90% of trash in the ocean that comes from people dumping it (in rivers) comes from just 10 rivers, all in China/Asia.

>So while still very clever, I sadly don't think this could ever make a difference.

I get what you mean by this, but why can't these solutions be used in places that are willing to make a difference? Anywhere this is deployed is making a difference locally. In the grand scheme of the world, yes we do need some big solutions to get some places up to speed but if a bubble wall cleans up some of the 10% other plastic in the water, then I am all for it. We can't keep our heads in the sand over the 90%, but we need to be happy about the small victories we can get.

I remember hearing about the machine that picks up trash in Baltimore at the Inner Harbor. It would take the current and push the trash into the machines conveyor belt. It was probably pick up a percent of a percent of the total world trash, but it made the harbor area much cleaner.
Learning Music, from the Perspective of a Mathematician
I’m quite involved in the Ed tech space and unfortunately it’s an environment where a lot of times it’s more expensive to be poor.
I guess that was a bit terse. NPR did a series called 'nice white parents' that went over some of these issues. But, the central question is basically "what is the goal here" . Do kids belong to the state, and the state decides what's best? (and what's involved there) Do kids belong to the parents, and parents decide what's best? What is education? Do we want them job ready? What if these are zero sum games. etc.
>middle aged female minority programmers
So you're purposely limiting your market to just a handful of people? I know of 1 maybe 2 middle-aged females who program. None are minority. I know of 0 minority non-greencard holders (in other words Black or Latino). Asian is different, I know several middle-aged female Asian developers.

And I was a manager for a while and couldn't get any resumes of minorities period. They just don't exist or are already happy where they were. It's truly a shame.
TrackJS for Node
I don't know if the Moment.js folks are reading this, but THANK YOU for your commitment to stability and security fixes.

Not all of us are in a situation where we're iterating through the JavaScript new hotness every couple years and still have significant legacy systems to maintain and support.
Willamette Valley here, and I feel you. Was really investing a lot of my optimism in the rain that was talked about for today, for over a week now — which doesn’t look like it’s gonna happen. This has been a long, long week.
That's not rolling your own; that's depending on 2 cloud providers. (the comment was clarified to not mean actual infrastructure, but still, you've really only shifted dependencies in almost every case)
Speaking as a student whose school primarily uses Google's suite (classroom, meet, etc..) but still has a few older solutions, some of which are free software, I can say that there's a common argument that schools should focus on pragmatism and working with what they have - the age-old argument that free software still is not accessible or easy to use. I don't beleive that this is still an issue.

Out of my current teachers and teachers I've had in the past, almost all of them were vocal about not liking Classroom or just didn't use it. It is basically a small layer on top of Google Drive & Meet that does not integrate anything nearly well enough. Most of my teachers seem to prefer Canvas, a free software solution to this, because it has more features. My teachers primarily cited the integrated quiz/test system as its biggest draw when I asked.

Classroom is also is very difficult for less-privileged students to use - speaking as someone who used to rely on a 4 GB of RAM netbook with a Pentium and was still using it for part of this quarantine, even with Linux things really get slow. This could primarily be attributed to relying on a lot of Google tabs at once (for Drive, forms for quizzes, etc) while Canvas I've never had to open more than a few maximum. My only other option is to buy a Chromebook and while my school can afford Chromebooks for every student, many students are relying on just using what they have.

With that, I don't think that the proprietary software really has all too much of an advantage in terms of pragmatism (which imo is even more important in schools). I don't think the usual arguments against adoption of free software really seem to hold up, though I assume that cost might be an issue that I'm not aware of seeing my district is rather rich.

I'd love to hear more teachers opinions on this. Hopefully this gave you an idea of how education tech is from a student user's endpoint.
Is Charging Your Phone All Day That Bad?
I think this assumes we all agree on what schools are for, and that we agree they exist "to teach students to be citizens of a strong, capable, independent, cooperating and free society."

I think many would agree with that purpose at face value, but aren't willing to empower schools to do anything beyond babysitting.
But do you have any reasoning with examples? Stallman does.
Considering how egregious the funding source is for this, I felt justified in flagging it.
An alternative interpretation of the point could be that one can stay motivated by framing one's projects in a way that allows one to get feedback often, but I understand this is easier to say than to do. Nonetheless, it's something that I'll definitely look into.
could someone take the time and explain to a moron like me why the mutability of moment is bad? i just don't get it. moment has always been my goto library for dealing with dates in javascript.
It would be nice...but I just don't see it working in practice.

Zoom was the best-positioned company in the world to handle the influx of remote meetings when the pandemic started, and even they buckled under the strain, at least initially. I can't imagine that Jitsi would be able to handle the load if all schools switched over to it tomorrow, without a couple billion dollars in additional funding.
Free software isn’t really free, it requires a team of software developers to maintain the self hosted servers that it’s running on. School budgets are pretty stretched, if they can get away with free OneDrive or gDrive, and the associated cloud suite of software, that doesn’t mean they can drop in libre-office and whatever cloud software is free.
At my university, we are heavily dependent upon Microsoft. The reasoning is that it has more features than the open source equivalents. It was pointed out that the over $1 million a year given to Microsoft could be used to implement those features in the open source tools and it wouldn't take long to get there. That was in the 1990's. We now give Microsoft many more millions a year and have ever since.
Absolutely not a doctor, so no way qualified to give professional advice, but the article states that not everyone followed the diet during all treatments, so they included all patients who complied at least during half of the cases, and the positive results are based on this extended group. This, and the suggested mechanism of why they think the method works, would lead me to believe that it makes sense to try it.

Wish you & your wife strength and all the best.
I had this problem with a hand cranked ikea standing desk, it was miserable to do regularly. Especially after I was moved to that from a convenient and fast spring loaded system.
Found the Democrat ;)