skysight-inc/HackerNews huggingface dataset:
> I'm wondering how do they test it, do they inject volunteers with the vacine, and they tell them to go infect themselves with a virus that 1 time out of 100 will kill them and an unknown percentage disable them?

Obviously no

They get a large set of people (tens of thousands), half placebo, and then check rates afterwards.
newcrobuzon you're a genius my friend someone should give you an award I loved your idea and how you approached it it's fantastic for developers. I'm a root Java dev and I have to say you did fantastic work to make developers life easier, you didn't take any approach you made your own this is awesome.
If you get Javascript working I feel like I'm getting back into AppJet days! This is fantastic stuff.
If you show me how I can help get the javascript stuff going I would be glad to help you in this initative since I have adopted NodeJS recently like you said, being a one man army you have to be efficient and JS makes me more efficient.
'after demonstrating safety and efficacy' is not weasel wording though, it's just a different benchmark than 'completing the study'.

The headline is inaccurate, but that's on Statnews.

When studies go really well, doctors consider themselves ethically obligated to end them early, so that the placebo group can receive the treatment. That these studies have planned end dates well into the future doesn't mean that they must run that long (or that it will take that long to collect sufficient safety data).
Because PC manufacturers don't insist on modifying core Windows for their bloatware, and carriers don't insist on certification for each and every update.

That is why the situation is better there.
Sure they can - read this comment: https://news.ycombinator.com/item?id=24411270
If they don't understand how the app works then they have no business reviewing it. Apple is not qualified to run a walled garden.
They probably could get some countries to indemnify them, they'd probably survive the damage to their
reputation.
Zigbee Alliance Standard for Smart Home Technology on Track for 2021 Release
I kinda disagree. The simple notion that I'm near a connected modem alters my brain (I'm not exaggerating for once).
Make sure you keep all your software up to date. Malvertising is pretty common, and adnauseum does a great job at firing payloads on your machine.

It is the equivalent of installing an app that silently opens every attachment that is emailed to you.
Gemini: A Grammar and Recommender System for Animated Transitions in Data Vis
A bad vaccine is pretty bad, and can easily be much worse than the virus. That's why we test them.
yea thats what i thought. Hope subaru offers some sort of upgrade to the head unit.
Exactly. Realistically vaccines are very safe, very occasionally they aren't. So you start small and increase the sample size gradually to manage that risk until you have enough data to show both efficacy and safety.

To be fair: it's also a global pandemic, and one very poorly controlled in the US. So there is real and quantifiable risk to being "too slow", also. Balancing between the two extremes isn't well-served by a static protocol, you'd do something different for a vaccine against ebola (where you want to take your time because there are very few cases) than you would for covid (more urgent, low thousands of people dying every day) than you would have in the 50's for polio (an ongoing global catastrophe).

So... sure. It's not at all unreasonable that an "emergency" vaccine approval might happen. Which is why it's such a disaster that the FDA has given the appearance of being politicized (c.f. the plasma nonsense announcement, the right wing journalist hired as a press manager by the white house and then fired from within the bureaucracy). There is real concern that this administration really would "cheat" with a vaccine announcement in a way unsupported by the science.

So now worry about blowback is forcing the pharma companies to, perhaps, err in the opposite direction by ruling out an emergency approval. I'm not sure that's right either.

(Or maybe they all know there's no way they'll have valid data before November and are just trying to shut the debate down early.)
You might be better off looking up the foundational texts for the various political philosophies. There's a lot of meaty and interesting stuff there. I'm partial to socialism, but reading the originals for liberalism, anarchism, anarcho-capitalism, etc is illuminating. People read (some of) this stuff in polisci degrees, but mostly they focus on quantitative micro stuff at the expense of the theories that motivate people. One thing polisci majors read is "Democracy in America" which was by a Frenchman taking a look at the new order post-revolution. As a socialist, I am partial to materialist views of history, and you can learn a lot by studying historical and scientific descriptions of the real conditions of societies. Usually they diverge quite significantly from whatever the ensconced and sheltered ruling class at the time likes to believe.
Vaccines shouldn't be rushed because that's how you kill people with vaccines. Phase 3 vaccine trials take 18-24 months for very good reasons.
Modern components are run much closer to their limits, simply due to engineering optimisations.

A 486 doesn't even need a heatsink, it's passively cooled and perfectly fine with that, as software of the time (mainly DOS) didn't even "idle" the CPU --- it was drawing full power all the time.

That also means if you manage to boot DOS or similar era software on a modern machine (especially a laptop) that was designed to have the CPU idled for most of its life, it is likely to go into thermal throttling immediately.
Is this the worst-case scenario? It doesn’t sound nearly as bad as covid-19.

My concern is that there’s an agency whose job is to minimize the risk of harm from a covid-19 vaccine, but not an agency whose job is to balance the risk of harm from a vaccine with the ongoing harm from not having a vaccine.
The bigger issue is if they rush a drug that does long term harm to people, it could destroy the company. This is a drug that they will be giving out to 300+ million people in the US along. Screwing it up would result in a massive amounts of lawsuits that they may not recover from. They don't want to risk that just for some political capital with a person who may not be in power in a few months.
Yes, there's a default app to handle SMS. And Google would like you to use Google Messages for that, which is inherently non-private because SMS (and RCS) aren't private.

but there's nothing about SMS that makes it a default other than it's what most people use. You have to open an app to send a message, there's no default way of sending a message where you aren't choosing an app first, and if you want something private and secure, you can choose something other than SMS.
TV, media can stop a U.S. meltdown on 11/4
> I'm wondering how do they test it, do they inject volunteers with the vacine, and they tell them to go infect themselves with a virus that 1 time out of 100 will kill them and an unknown percentage disable them?

No, and this is why Phase III trials take a long time, potentially a very long time if we actually get a handle on the virus with measures like masking and social distancing.

Here's the protocol:

1. Volunteers get the vaccine (experimental arm) or a placebo (control arm).

2. They go about their lives.

3. Both study arms report any cases of COVID they develop. Also, any deleterious symptom (potential side effects).

4. If the vaccine arm has a statistically significant reduction in infection rates, and/or severity, everyone wins and the study is concluded.

This process can take years if the background rate of infection is low enough.
I disagree. It's one thing to not have the time or bandwidth to change or add a feature. Certainly free users aren't entitled to a developers time. It's another thing to disagree with a style of usage and refuse to accommodate users out of principle. The software is marketed as an open source replacement for utorrent. If he wanted to treat it as his little fiefdom, he shouldn't position it as a replacement for utorrent. If I had any expectation that a pull request for this feature would be accepted, I would fix it myself. But his demeanor suggests otherwise. That's not the way to approach software that positions itself as a community project.
"political decision" in this context is making a decision to approve something to increase the odds of one candidate winning. It is not "a decision by a politician" but rather "a decision with the primary motivation being political gains only".
Do Stat Holidays Matter to Remote Workers?
And ?...

Again and again: my point is that the democratic forces opposing the dictatorship didn't engage in violence.

The violence in the crisis that led to the collapse of the dictatorship of Colonels was by the dictatorship itself and the war against Turkey.

All repressive regimes repress. My point is how the democrats should respond.
Fully Homomorphic Encryption does also work. But there's other issues that make it infeasible outside of very specific niches (an explosion in the compute cost).
> steps to achieve this

To clarify, you mean this as hypothetical advice for a Tech Lead, right?
Here in Europe they are freed from legal consequences should the vaccine harm someone. Instead our countries are to pay any occurring damaging. So I don’t quiet get what motivated the vaccine makers to await the approval given that they are practically free from prosecution anyway.
I feel like ending the pandemic is not a motivation that is likely to make a researcher (an expert) rush things and end up hurting more people. Greed or glory is much more likely to be a motivator for that kind of mistake.
MikroORM 4: Filling the Gaps
Do your users care if it's done the "right" way so long as it works the way they want?

Cannot tooling and methodology make up for poor documentation or "code quality"?
Agreed. Once you hit it once, you can hold ENTER to keep clicking it, but that can still take a long time.
This is how I've heard some people describe the difference between a 10x and 100x dev.
i don't think it's possible without heavy moderation, even more so than on non-political forums
i feel like there is an appropriate middle ground somewhere between "shiny-new-toy" and ncurses...
Quote:[I've recently heard an argument that the probability of being injured/killed by a vaccine (e.g. due to complications, allergies, etc]
is extremely remote...

See? I just fixed it!

Oh wait! You’re just trolling aren’t you?
We know that they trigger an immune response, but that alone doesn't necessarily mean much.

For example, an early SARS vaccine candidate triggered an immune response in tests, but that immune response in practice actually made SARS infections worse.[1]

[1]: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3335060/
Argentina did exactly that on 2001. Life savings stolen forever. To this day, most people save their dollars in their houses because no one trust banks in the long term.
Personality traits affect the open source development process
What was the initiative you had? The common concern that you fixed?
Okay, and that's fine, but why her? Why not quote some virologist or someone who isn't.. oh I don't know, currently running as vice president in the upcoming election? At best the author is making the same mistake being talked about in the article by accident. At worst they are quoting her because they support her bid in the upcoming election. Either way it's politically biased.
A few seconds of googling turns up these relevant articles on how browsers paint via GPU (which date back many years):

- https://www.chromium.org/developers/design-documents/gpu-acc...

- https://www.urbaninsight.com/article/improving-html5-app-per...

- https://hacks.mozilla.org/2017/10/the-whole-web-at-maximum-f...

and also how they handle painting and redrawing in general:

- https://www.phpied.com/rendering-repaint-reflowrelayout-rest...

- https://www.html5rocks.com/en/tutorials/internals/howbrowser...

- https://james-priest.github.io/udacity-nanodegree-mws/course...

So no, browsers don't "recompute the entire window". They know what DOM nodes have been mutated, and are able to fairly efficiently redraw just those pieces of the UI that have changed.

I haven't watched the video yet, but React's approach to defining UI structure and updates is considerably different than your typical desktop UI toolkit (ie, Swing, Windows Forms, MFC, Qt, etc). With those classical frameworks, you generally have a bunch of object-oriented class inheritance hierarchies and manually instantiated child widgets with specific parameters (`button.setWidth(80)`, `button.setPosition(20, 40)`, etc), then add a lot of event listeners to manually modify both the data and the UI.

As I previously mentioned, React expects to work with a "retained mode" environment, such as the DOM, where previously-set UI layouts persist until such time as they are modified. React is explicitly based on determining what the current UI _ought_ too look like based on your current state. The problem that frequently plagued jQuery-type UIs is figuring out how to transition the UI contents from where it was previously to where it needs to be now, taking into account all the possible permutations of what could be shown on screen. With React, you tell it what UI output you want at any point in time based on your current state, and it takes care of figuring out what relatively minimal set of changes actually need to be applied.
Agreed, it's the community that makes it useful. I mainly made this for my friends to use, was curious what HN users would think, although didn't expect such a toxic comment so soon...[edit] I'm leaving that comment up for a bit as it illustrates the problem I think. Perhaps a minimum word count with a valid word filter would help push people in the right direction or gamification, something like the tribunal(https://leagueoflegends.fandom.com/wiki/The_Tribunal) from League of Legends to ban toxic members.
I'd love to hear more about what "the capacitor plague" is
Well, this is a case of high risks and high rewards. I don't know a lot about business, but I don't find it hard to imagine that there's some companies out there that are willing to take the risk, especially if they have some kind of government agreement that can alleviate their liability.
If you ever bought a car, your lifestyle would likely be very different/shifted, and your anticipated viewpoints might not hold. It's like saying, "If I was vegetarian, I would like these foods." You have no idea what you would like because you have never been part of that subculture.
No one will be told to go intentionally infect themselves. There will be no human virus challenge trials in the US as that would obviously never pass a review board. Instead they will vaccinate a study group and then compare infections, symptoms, and deaths versus a control group.

The best estimate of infection fatality rate is 0.65%, not 1%.

https://www.cdc.gov/coronavirus/2019-ncov/hcp/planning-scena...
about.google is about google. blog.google is a blog maintained by google.

So google.google should google 'Google' on google for you.
> Google released the "Nearby Share" feature a couple weeks ago

...and insisted to bring it to the top of the share menu without a way to disable it.

I don't even think it was malicious intent, like growth hacking or something. It's just a sloppy implementation.

... like Googles camera and photos apps that stopped respecting the accessibility setting not to use haptic feedback and enabled it for some rare and random ui elements, like tilting an image or changing camera modes.

Or how Android 11 new (and random?) background animations during notification bar pull down does not honor disabled animations, another accessibility feature.

... or the new button right next to the screenshot button in the app switcher that just does not appear to do anything? It just makes the app switcher unresponsive until you press the "x"-button. They probably just forgot to add a feature there.
Think he means event sourcing in a distributed transaction context, not a front-end context: https://microservices.io/patterns/data/event-sourcing.html
Not GP, but as someone with a small child, there are two big reasons. Kids between the ages of 1-6 require pretty much constant attention/interaction/supervision, this makes it very hard to work from home. Virtual instruction tends to just be a frustrating experience for everyone and still requires just as much parental supervision.

The second (and more important in my opinion) is that the primary developmental events that take place at kindergarten age are social. How to interact and relate to others individually and as groups. For cognitive development, it is structured imaginative play that is critical, and near impossible to do virtually.

Many parents fear their children will miss out on this key developmental stage.
Not to forget that while I might go to an article written ten years ago, the Wayback archive won't show me a related article that you published two years ago updating the article information or correcting a mistake.
AND he messes up the search results for my keyboard layout!
They were rolling out a free cashback program until recently. Now it's oddly locked behind an overpriced monthly plan.
Don't know how this isn't mentioned already, but I've used FreeTaxUSA for the last two years, and I've really enjoyed it. It does not hold your hand as much as TurboTax, but they'll walk you through every step. I still pretty easy to use, plus it's rather affordable.

https://www.freetaxusa.com/
Book/CD clubs used to work that way. They shipped you the 'book of the month' and then you'd either return it or pay for it.
What exactly is this news source doing here? Just repackaging a press release?
There are very important questions being asked here about the wording. Journalists should be the one thinking up these questions and asking them. They shouldn't publish these kinds of statements without doing this. Otherwise they are no more than propaganda machines.

Fake news is not only out-right lying, it's journalists not doing their jobs of asking the hard questions.
Random seed of original Minecraft thumbnail(pack.png) found
Ah I see. But then you should have said "Sounds just like Pascal's Wager". That's a great point and not generic at all.

The trouble with what you did post is that it landed with readers as generic religious flamewar whether you meant it that way or not. I realize it's not always possible to predict how things will land, but the burden is on the commenter to disambiguate intent. Here are some previous explanations on this theme if interested:

https://hn.algolia.com/?dateRange=all&page=0&prefix=false&so...

https://hn.algolia.com/?dateRange=all&page=0&prefix=true&sor...

https://hn.algolia.com/?dateRange=all&page=0&prefix=true&sor...
The usual protocols have been well and truly thrown out the window, so I don't know what the comparison point would be. Moderna didn't even finish animal trials before giving their vaccine to humans.
For a desktop use, openbsd feels super sluggish compared to the same hardware running linux. I love the way things are configured in openbsd, it is very straightforward. But the fact that it is noticeably slower than linux is what made me go back to linux. I wish we could have a linux distro with the same configuration philosophy as the BSDs. I recently started using gentoo and I'm enjoying having bare tools to configure the system, and having no systemd is a plus IMHO.
should have added that that the vaccine has very limited $$ potential (can't charge a gazillion for it due to bad PR and competition) and most makers have hundred billion brands that can be ruined by this. So they aren't going to risk their company for this. Lastly, suppose Acme Pharma released it against all common sense, all over the media scientists would talk against it, so lose-lose.
I do everything I can to do the opposite of read comments on political news articles so if you make the opposite of this product I'll subscribe.
There's still the problem that you can still coerce and verify then use surveillance and the fear of surveillance to keep people from changing their vote. Random rechecks the day the polls close would keep a lot of people from risking changing their vote after the initial check-in.

Even beyond any theoretical security measures one huge benefit of in person voting is it limits the available attack. With IPV to steal an election you have to find a way to either physically bring enough people to enough polling places to swing the election or corrupt the poll watcher system and steal it in the counting phase. With electronic voting anyone in the world has a chance to attack you. Anything that requires Joe/Jane Citizen to reliably or securely operate their computer is kind of doomed for a long time IMO.
The link needs http:// to work. In 2020 Sourceforge doesn't host project webpages on https.

http://opentaxsolver.sourceforge.net/
The larger the set the faster the results, but a large set is expensive. "Afterwards" is sort of a simplification. The study arms are compared regularly throughout in case the study needs to be ended one way or the other (Data and Safety Monitoring Committee). (If the vaccine is effective: great, we want to ramp up production and give it to everyone ASAP. If the vaccine is ineffective or has very bad side effects, we also want to conclude the study.)
I wish Google cared more about the experience of photographers in Android. There's no way to pick images from Google Photos, so if you want to post 4 images taken at different times to Twitter or Instagram and you didn't take them just today, you have to first find them, then put them in a temp album (or else find them again later), then delete them from your phone, (here's where you re-find them if you didn't put them in an album first!) then re-download them. Then you can select them from the device folder "Recovered". Why is choosing images so bare-metal? Or why can't we have a virtual folder called Quick Collection or something, like there is in Lightroom?

I have of other gripes as a photographer but they're mostly about Google Photos and not Android itself.