skysight-inc/HackerNews huggingface dataset:
You may note I used the word exclusively. TADs are hardly the end all be all of gene function. Epigenetics has more to do with gene regulation than function, and TADs aren't remotely close to the dominant force in epigenetics either.

Gene mapping through genetic linkage maps hasnt really been a major part of identifying and classifying genes for a while - not since sequencing became accessible. You could consider a genome sequence the ultimate physical (not linkage) map, but that's a couple decades out of fashion.

Edit: and im still not sure whether you're defending or attacking the naming of the hh family of genes, but yes, I'm intimately familiar with the hedgehog signaling pathway, and just because the hh loss of function makes fruit fly embryos look spiky doesn't mean that the name is justified or meaningful. Amd a basic problem in ontology is figuring out what that unifying theme should be to name all genes around, its not as easy as in chemistry. But until that's solved, the world loses nothing by changing shh to something less embarrassing so patients don't have to deal with being told their cancer has driver mutations in a pathway involving sonic the hedgehog.

Is your background in biology/molecular biology? I'm happy to share some links to resources if you'd like to read up on the state of the art now, including on gene ontology (GO). GO is an attempt to unify how genes are represented to give more meaning to the representations. I have my doubts about how successful these initiatives will be, but they're still really fascinating stuff. The field has come a long way since Morgan and Sturtevant developed that first linkage map back in 1913. And in epigenetics, there's so much more than TADs. There's the usual methylation/history acetylation etc, but also things like alternative splicing (perhaps not strictly epigenetics) that significantly change what genes do and what sequence even gets translated from the same locus. There's a lot of amazing stuff in happy to share some resources that I think are a good place to get caught up on the state of the art.
Hah! Loved the interview, thanks for sharing.
I wish I could work on these magical projects that people with blogs work on, in which everything works like it's supposed to do. In my experience, though, it's not unusual to be forced by management to migrate to a new RDBMS a year into a project. The last time it happened to me, we were using Rails and had very little difficulty migrating from PostgreSQL to MySQL. We didn't need to alter application code or rewrite tests and only had to manage config changes and migrate the data. I imagine the transition wouldn't be much different if we had been using Django.
Build a Command Line Interface with Python, Poetry and Click
There are people of all sorts: amateurs that want to play with the data but will not make study of it their primary field, trainees that will make use of tabular data extensively in their career, and then experts in more rarefied fields (e.g. immunology, clinicians, etc.)

If I can get a trained immunologist looking at my data, I'd much rather have 5 more minutes of their analytical skills than teaching them about common data exchange pitfalls.
It's actually lower than retail bank interest rates. For example, if they get a huge mortgage, usually it is at least 100 basis points lower. This is because these people are considered extremely low risk.
CapsuleGAN for Face Generation – What is someone generates your photo with AI
Huh, I always thought that it was oxidation from getting wet that damaged the blade. I even remember getting a recommendation to clean the blade with alcohol to dry it of faster.

I always find myself falling for this sort of 'Well of course the answer is <simplified answer that is wrong>'

Edit: I've posted to /r/ImageStabilization/ for that first image - https://www.reddit.com/r/ImageStabilization/comments/i54p9s/...
> Yes, but that doesn't change with rustc vs cargo
> though; it's still a single rustc invocation to
> compile all those files.

When using Bazel instead of Cargo the developer can split the build graph into much smaller crates (down to one per module if desired), and still treat the entire assembly as one package.

I should emphasize that this is a limitation of Cargo, not rustc. rustc does just fine with big libraries, it's only Cargo that makes it difficult to write hundred-crate packages.
The paper is not about listening to your customers at all, it is suggesting ways to make negative reviews seem ridiculous so that negative reviews actually form a positive impression.

I think the takeaway is to make your critics look like hyperbolic dimwits by being nice and using real names. It not obvious this is the best rebuttal strategy. I see companies often get hyper factual and cold with responses to negative reviews. When responding to a negative review, you are writing not to that person, but rather to the audience that reads reviews.
I find Clear Linux quite nice, but I don't know if it could replace the lost CPU revenue :-\
Girl post homophobic comments from a popular creator
It's a fictitious example. I didn't say there was no weapon, nor said it was definitely theft. The point is that submitting a GET request in a public setting does not mean no crime.

Coercion can be the difference between asking for money and theft. In the case of this intel data, it was clearly coerced from a server - it's not like it was linked on Google, they had to specially craft URLs to coerce the data out.
I think microsoft should not make a version of office that works on apple silicon until apple clears up this mess.
This guys website is weird.

I first noticed as scrolling doesnt work with the keyboard. Upon inspection of HTML hes using weird shadow dom stuff.

Why do people do stuff like this? Its a static site, modern HTML and CSS are huge and can handle nearly any situation.
Seems a little unfair to cargo to give it a scathing review when your alternative ecosystem is C++ or Haskell.

The basic complaint boils down to "packages aren't namespaced" and "someone already took the 'fuse' package", which has been a long running controversy for exactly that name-squatting reason.

However, Cargo is great.

> Rust's default build system (Cargo) and package repository (crates.io) are the opposite. They combine the worst parts of Cabal/Hackage and NPM, resulting in a user experience that is somehow inferior to both.

No. They don't. That's your opinion, not a fact, and I completely disagree. Lots of people disagree. Your arbitrary assertion is unsubstantiated and I reject it. :) Perhaps you meant "resulting in a user experience that I found somehow inferior to both".

If you don't like it, and you prefer to use bazel, then by all means be welcome to do so... but I think a little bit of acknowledgement is in order that ... frankly, that behavior should be discouraged.

We want a unified good build system for rust, not a ridiculous mess of difference package managers and build systems like in some other language ecosystems. Sometimes, conformity is a better approach, and I would be deeply saddened to see rust go that way.

I'm very impressed with the efforts to bring wasm support to cargo, and the other initiatives.

Be nice. Lots of people work really hard on cargo. They're doing a great job.
> People get confused because government gets involved and you end up with cronyism.

Government was involved from the beginning; capitalism was historically a redirection of the power of government from serving the feudal aristocracy to serving the mercantile class.

The utopian (and largely self-inconsistent) rationalizations for capitalism as something that magically exists separate from government and cronyism came much later than capitalism itself, and most of them even later than the early socialist critique of the reality of capitalism.
Well, they would rightly argue that if you want to ensure market freedom, then you should let them keep their doors open and let people decide whether to attend and let people decide whether they want to work. Just free parties making decisions.

If you decide you're going to force a shutdown and result in the unemployment of millions, you're going to have to ensure they have jobs to come back to.
I really doubt that we will have a vaccine for the general population in 2-3mo. No vaccine manufacturer that I know of is even expecting phase 3 results until the end of this year at the earliest. And then you have to start using supply for first responders, healthcare workers, etc. and then move to gen. pop.
I have to agree with your points. I'm someone who uses Soundcloud because a lot of the genres I'm into are not that popular and the producers have between 500 to 5k followers. Because of this, a lot of them simply aren't on Spotify.
I would definitely use an app that connects me with other people that are into the same niche genre because it's so hard to find people into this music anyway. The cool thing though is that when you do meet someone in the same hard-to-find niche, the friendship is much more stronger.

tldr; OP add SoundCloud support please!
Yes thank you for not fauning over Cargo like many other reviews.

The simple fact is Cargo did not learn from prior art to the extent Rust did.

Things have gotten better, but Rust is still better designed. Hopefully Cargo can someday catch up.
Wonder if this will increase crime rates...

Thoughts?
or someone doesn't accidentally just entirely overlook it and wind up with just http in prod.
Scientific Management of Software Production
my takeaway from this is that the human body is actually really complex. even the immunologists quoted cannot say for sure about how the body responds to certain viruses. each one of us is unique and has different response levels. however, it's good to know that children have more a aggressive immune system response than older people and hopefully make their bodies somehow adapt to the Covid-19 virus.
Limited does not mean he hasn’t accomplished anything, only that he’s not speaking for the entire community and wording his post that way doesn’t add anything to it.

He’s obviously very proficient, which is going to shape your perspective of what’s easy and how much control you want just like the scale of the projects you work on and the number and skill levels of your team.

There’s nothing wrong with his opinion - my objection is the overly broad framing. It would have been just as good as “here are some things which worked for us” and letting the reader decide whether they are in the same situation.
Yeah, I remember my parents needing to clean their windshield every time we went on the highway. It'd get absolutely caked in yellow and brown spatters after merely an hour or two.

As for me, I've never cleaned my windshield in my life. The rain washes off the little bits of dust. There's nothing else to clean.
Google sets timeline for deprecating ‘classic’ Google Sites
Annoyingly the (not-ssh) AWS session manager cli doesn't seem to implement this.
How is Epic able to attract great talent when they’re headquartered in a small town in the middle of North Carolina? It’s a beautiful area with plenty of activities to enjoy outside of work but it seems pretty isolated from the rest of the tech world even for the East Coast.
Have the videos of the conference been released? I haven't been able to find them anywhere
My point was that even without anyone taking that risk, the information will spread.

Someone reads the code, mentions it to a friend, who adds it to a blog post, which gets cited in a wiki, which gets read by a developer unaware of the source. If the information is useful, it will end up getting spread.
If the "platform" concept works out then those things probably should move out of the standard library. Look at how many people had to upgrade language versions to deal with DoS attacks on their HashMap implementations, when it should've been just a case of upgrading their HashMap library.
Yes, although this gets better with time.

People who care enough to want to use these units have figured out CPU dispatch by now, too.
“firefly boom”!
In Michigan in 2018: https://www.michiganradio.org/post/firefly-boom-lighting-mic...
> It generally doesn't pay to appear stern, cold or callous among most people (though for some it does). Sympathetic positions are usually more popular, which is why you see corporate messaging overwhelmingly on this side.

Sure, but it's obviously brazenly disingenuous. Do you think the companies believe that people buy that. That a company actually cares about XYZ. And that the social media/advertising/marketing campaign staff they pay to come up with this had nothing to do with it.

Why is the idea that a company has zero interest in your personal well-being or anything else about you, outside of how much potential revenue you're worth, so taboo?

There are businesses and products that incorporate some level of social good or net-positive impact, but you can bet if continuing to do so put them in the red that would be quietly ushered out stage left.

But it's a business, not a charity.

Do I think Coca-Cola _really cares_ about (insert recent tragic event or latest social cause)? No. Do you? Does anyone? Do we care that they don't care?

So why does the entire world keep up the charades, and not stay "Stop posting trite corporate marketing, do you think you're fooling anyone?"
Apparently it’s not just “pirates“[1]There are state sponsored illegal fishing in the eastern & South Pacific by the usual suspects.

[1] https://thespinoff.co.nz/society/30-03-2016/how-chinas-illeg...
Ah, so you're not saying that you take the same project and port it from Cargo to Bazel and it somehow does less work, you're saying that it's easier to make projects with a larger number of smaller crates with Bazel than Cargo? That would be the bit I'm missing, Bazel and Cargo should invoke rustc the same amount of times per crate: once. Cargo doesn't change the compilation model of the language.

(Sorry, I feel a bit dense here, but I am very curious to understand exactly. I haven't used Bazel a ton yet, but am very interested in it.)
Won't help. You can always execute "code" if you try hard enough. Not all "code" is in the form of some JS file loaded into the extension context: it can be any custom sequence of instructions. There is no way to distinguish code from data.
1. For a low competition market I am looking at browser automation of user interaction. I recently created an original solution for a niche set of problems that incidentally solves many other more common problems.

2. The cool thing about this space is that it isn’t new technology that delivers 10x improvements. The opposite actually. 10x improvements are found by doing the least possible effort in a tiny library, scaling to support a wider problem space, and doing it substantial better than large products present in the marketplace.

The few competitors are easy to search but most of the commercial products are so expensive that it’s hard to really gauge the precise performance capabilities are the smaller players without a large financial investment.

3. I am just now learning about second order effects from this thing as I extend it to support execution across networks/VMs. There are all manner of second order surprises that emerge from better software automation.
i mean somebody has to hire minimum wage worker for 1000+ hours before it probably breaks even with equipment cost. It seems like the business is in scamming everyone with the skyrocket valuations and pocketing the salary. Then rinse and repeat.
> the government could have bailed out underwater homeowners

Why reward people who gambled and lost? Bust them out.

People will either buy the houses at more reasonable prices or (more likely in this case) the banks will renegotiate more reasonable terms with the original mortgage holders because they have too much supply and no buyers.

> instead of pouring money into banks and letting people suffer. Thanks, Obama.

That wasn't possible as liquidity also died. Solvent businesses couldn't give people paychecks because the banks had no cash. You had to bail the banks.

HOWEVER, what needed to happen was that the bank investors needed to get busted out. That was where Obama went wrong.
Notice that the article never tells you what advice they didn't listen to, and mentions a single mistake by a single company. The only general principle that's useful (as opposed to the obligatory observations on age and race) is hiring people with food industry experience.
Anecdata: I've seen three or four companies that look like this, one attracted VC (after proven traction), one was rejected cause (external risk) and the others are a nice tidy business for the founders and a few employees.

Sometimes I hear, pejoratively, a "lifestyle" business.
Required (fiction) reading for anyone interested in this space: "Sourdough: A Novel" by Robin Sloan. It's fantastic!
They probably use https://devnull-as-a-service.com/
It's funny you say that... https://news.ycombinator.com/item?id=19529921

We're hiring too. Looking for an engineer with some game dev experience.
Also, the ~ needs to be the first on the line, so the key sequence is often <return>~. to kill a hung session.

And good idea to ctrl-c ctrl-U before hitting return, just in case there was a command in the buffer and the session wasn’t actually hung up.
This 100%. I recall many a fun night at $BIGCORP burning the midnight oil, receiving the warning emails that my "unauthorised software" had been reported to my manager, and that it had been quarantined away for my own safety and convenience. Given that $BIGCORP was a tech firm my manager would be intensely delighted that they would receive regular midnight notifications that I was doing my job. Whatever that damn thing cost it would have been cheaper to let the malware do its thing.
Btw, this doesn't work in zsh. It does work in bash. But I just lost my session from typing `~.` Don't even have to press enter!
Correct. This is just my muscle memory, but I guess it's from checking if I can just terminate a program first, then clearing any input so the escape char can come at the beginning of the line. I probably learned this when using ssh sessions embedded in a GNUscreen session running on a jump host, where you had to specify a different character, or maybe send ~~. . I think I had fun standing up ad-hoc port-fowardings with ~C too.
Facebook removes fake accounts tied to Romania that posed as Trump fans
Intuition can die often, but on the other hand many individual processes within immunology are somewhat well characterized as far as biology goes, and are amazing. The VDJ recombination process for B and T cell development is a stochastic-engineering-like feat of self-driven mutation (not just slight code changes but actually chopping up parts of our DNA and rearranging their order) and is occurring constantly in huge numbers of developing lymphocytes to generate structurally new proteins under very close scrutiny, allowing our immune system to adapt to previously unseen infections.

https://en.m.wikipedia.org/wiki/V(D)J_recombination
Who did the business scam? The investors not doing their due diligence? I invest in businesses, and my responsibilities go further than signing a check.
You joke, but an ex-security guy at my company literally told me “this file can’t be in plain text on disk. Base64 encode it”
> Is it moral?

No. We don't live in a moral world, though.
> Many of the people she knows trying to make a living selling food are immigrants, women and people of color — far different than the food tech would-be entrepreneurs. “They are young, white,” she says, “the kind of people you see in a J. Crew catalog.”

> There is also a big difference in who they bring in to work at their companies. Albrecht hires local workers to make her kimchi, many of whom have worked preparing and handling food for years. They look very different from the workers at the food tech companies.

> “All these people they hire are also from Silicon Valley companies who have no experience in a food manufacturing company,” Albrecht says. “Often these positions are for logistics, operations, marketing, all those people. Those are the people they hire.”

Amazing what is an acceptable thing to be upset about these days.
Scrolling works with keyboard. There is nothing weird about shadow dom, it's part of the standard.
Qatar is listed with the second-highest rate of suicides, so it isn't quite as easy as that. Islam also isn't the only difference between Indonesia and Papua New Guinea: GDP is five times as much in the former, with $15,000 p.a. vs. $3,000.

Just scanning the map, I can't help but think of alcoholism: Greenland, Russia, Eastern Europe, and Australia have relatively high rates, and enjoying a bit too much is the common theme I can think of. It would even include any correlation with adherence to islam, since alcohol consumption is one of the largest differences in lifestyle setting muslims apart from all others.
There's much unhappiness about "snaps", the "store", and that Ubuntu 20.04 is too closely tied to the mothership. Some people are moving to Mint for that reason. Yes, there's not that much of a tie to HQ yet, but remember how Windows slowly went from a standalone OS to "software as a service".
Trump Bans TikTok September 20
We already are.
How can you even do that?

SVG is insane

edit: like this:

<title>Comparison of several satellite navigation system orbits</title>
<switch>
<desc systemLanguage="es">Comparación de las órbitas geoestacionaria, GPS, GLONASS, Galileo y BeiDou (satélites de órbita media), Estación Espacial Internacional, Telescopio Espacial Hubble, Constelación Iridium y órbita cementerio con los cinturones de radiación de Van Allen y el tamaño nominal de la tierra, ilustración de CMG Lee. Bitmap de la Tierra https://commons.wikimedia.org/wiki/File:North_pole_february_ice-pack_1978-2002.png by Geo Swan. La órbita de la Luna es cerca de 9 veces más grande (en radio y largo) que la órbita geoestacionaria. Esta animación se mueve a 1 hora por segundo. En el archivo SVG, se puede posicionar el mouse sobre una órbita o su nombre para resaltarla y hacer clic para ir a su respectivo articulo en la Wikipedia.</desc>
Learn Data Structure and Algorithm in JavaScript – Part 12
Quick issue to fix on https://storycreatorapp.com/features - both the Trim Video and Resize GIF paragraphs have the same text content.
I have experienced all that and more. I speak my experience not my opinion.

I am interested in facts not emotions. Facts work. Let us agree 1+1=2 then let's talk about 1+3 and 2+1,etc... Let us agree that even if you are helpless and hopeless against the realities of life, that is the driver of suicidal tendencies (not depression neccesarily).

How can we solve a problem if we don't agree it is a problem and we don't agree what the prolem is?

Then let us talk about the impossible and let us talk about defeating reality. I would love to talk about how to overcome the impossible. Or we can agree a person is hopeless and helpless against life , they lack control over their thoughts or emotionsand for that reason their only escape is suicide. But let us use facts and critical thinking. I tried emotions, I tried it all but only truth helped me.

Why are so many technical people on here dead set on the impossible and a hopeless reality? This very technology we use to talk to each other was impossible. Not improbable but dead set impossible even half a century or less ago! It should be impossible or me to be alive and talking to you but here I am! Why is hope so unpopular? Ok, you can kill yourself if you want, society approves if it makes you feel better. Now can we talk honestly and critically about the facts, and can you pose factual adversarial challenges against my argument?