skysight-inc/HackerNews huggingface dataset:
For context, Irina Conboy (the senior author of this work) has been publishing on the concept of tissue regeneration for a long time now, but I think it's a bit of an exaggeration to consider this line of work to constitute a reversal of aging.

This New Atlas article alludes to work done in 2005, which was a paper Irina published in Nature [1] while she was a postdoc in Tom Rando's lab. They had joined the circulatory systems of young and old mice, and showed that this process could improve the regeneration of both blood and muscle. Significantly, they had highlighted a cellular pathway, called Notch, which they said was responsible for this effect.

In the years since, Irina has focused on the same models -- regeneration of blood and muscle -- but has been looking for a better way than Notch to explain the original findings. It's clear that there are factors in young blood to which some old cells can respond favorably. Importantly, however, none of these measures actually reverse aging in the ways that matter (lengthening telomeres, correcting oxidative damage, etc). Experimental mice treated this way also don't live any longer than usual, except for the very specific cases where you're treating a disorder that would normally shorten their lifespans.

1: https://www.nature.com/articles/nature03260
I have one as well, sometimes it gets so hot that it disconnects from the machine mid file transfer. However I've had it for a few years and it still works.
I think I am familiar with Rust–I spent a week or so working with it–and I ran into many of these exact issues. I appreciate it very much when someone can give a viewpoint of of using a language beyond the superficial one ("arrays start at one in Lua"), or complains about something core to the language ("C pointers are confusing") and actually says something you will run into but is not obvious from having a basic knowledge of the thing ("while Python supports functional programming, it does not do so very well"). Rust's (intentionally) anemic standard library, strange dance around nightly ("we never break things…except in nightly, which we know you are using for your project because we gated all the features behind it") and a general sort of superiority towards npm when cargo/crates.io shares many of the same issues are the ones I ran into personally. And again, you don't have to be an expert to see these, but they're in this sweet spot between nonobvious and "something that'll go away if you use the language more".
Better question is what is the source and license of those photos? :)
Maybe because their choices and actions didn’t just harm them, but others they came into contact with. When a person puts others lives and health at risk because they are an idiot then they don’t deserve sympathy. They got what they deserved.
Craigslist has lost a ton of market share to literally every other company. I haven’t used it in years cuz there are just better products.
How is that different from our brains? All that exists in us may very well be our neuronal representations of a concept. Alternatively, the meaning of a representation in a computer is interpreted and acted upon by other elements within a computer
The Stupid War
I suspect instances of bias introduced by other-than cultural, social, human, and perceptual dynamics are also present.
> If both parents have a recessive gene for a recessive genetic disorder, their offspring will inherit that disorder. That's why people have such an issue with it.

This is simply not accurate. Or rather, it's partially accurate, and it's only part of the story. The increase in risk isn't huge, and the amount it happens effectively leads little to be concerned about.

"Contrary to widely held beliefs and longstanding taboos in America, first cousins can have children together without a great risk of birth defects or genetic disease, scientists are reporting today. They say there is no biological reason to discourage cousins from marrying."

"'In some parts of the world,' the report says, '20 to 60 percent of all marriages are between close biological relatives.'"

"Dr. Motulsky said researchers did not know why marriage between cousins was viewed with such distaste in the United States. He said some of the revulsion might have stemmed from the eugenics movement, which intended to improve the human race by deciding who should be allowed to breed. The movement flourished in this country early in the 20th century." [1]

https://www.nytimes.com/2002/04/04/us/few-risks-seen-to-the-...
This has happened to me with gmail. Zipfiles I had sent in the past are no longer allowed to be downloaded from my sent items folder through the standard interface.
> rustdoc, being a part of the Rust distribution,
> has the same stability guarantees that Rust does:
> once it gains a feature, it will never go away. We
> (well, not me I don't really work on rustdoc, to be
> clear) need the capacity to try out new features
> without committing to them, same as features in the
> language.

I guess I expect rustdoc and rustc to be much less tightly coupled, so that I could use (for example) stable rustc and nightly rustdoc on the same code.

In the current model, I can't use nightly rustdoc features without also using nightly rustc, because the annotations are processed by both systems.

You could imagine an alternate model where rustc stabilizes `#[doc(...)]` and leaves everything in there up to rustdoc's interpretation, and nightly rustdoc might enable new parameters to the #[doc] annotation.

> Neither of these support namespacing though, right?

That's correct. I meant that mostly in terms of "package registries are not a new and untested idea". It's like using strings for file paths: not obviously a bad idea, turns out to be unworkable for obscure reasons, and as a new language Rust got to avoid that particular mistake. It feels like crates.io didn't (/ doesn't) have a similar process of avoiding known mistakes.

> This shouldn't change based on if you're using Cargo
> or not; if it's re-building dependencies every time
> you touch a file, that is a bug.

Given a crate with a hundred files, each one fairly independent of the other (i.e. a broad shallow build graph), changing one requires (if I understand rustc correctly) recompiling them all. Otherwise the `crate::` references can't be type-checked.
Here David Sinclair’s response back in May https://twitter.com/davidasinclair/status/125991292869585715...
This is a nice summary of the basics of immunology and how it relates to SARS-CoV-2.

It's good to see a piece that shows how complex the science behind COVID is, in the middle of so many contradictory or over-simplified news.
They Just Don’t Listen': SF Kimchi Maker Saw 'Food Tech' Practices Up Close
Ubuntu 4.10 -> 19.04: https://www.youtube.com/watch?v=nZdrjATI8BA

Gnome 1, 2, and 3: https://www.youtube.com/watch?v=dMak0R_fE2g
Fleet management solutions are built for EDL requirements. They have event based logging and won't log data at high sample rates and don't send it to a server of your choice because they want you to use their subscription based dashboard.
I'm on the fringes of this project, trying to shake enough free time loose to contribute to coding - I'm still employed beating code into submission for NASA.

What we have is access to the source code for the D-machine emulator that Interlisp-D/Medley Common Lisp ran on in the 1980's.

The emulator was quite usable on 1980-s hardware - I worked for the company that sold it in the late 80s and early 90s.

We are still deciding stuff like what exact open source license to use, and how much priority to give to the two main goals:

* Historical - can it run old system dumps with important systems like NoteCards, LOOPS, LFG...

* Modernization - integration with host OS (clipboard, file system, networking), increasing memory space, adding Unicode
Coming from a dynamic typing background, I have to say Rust didn't feel much worse than Scala or OCaml to me.
In fact, it was just released a few days ago.
You have a lot of faith in how technically versed the law and courts are on these topics - because they sure haven't kept up with the times. And even if they were willing to split hairs over these technical details:

No civilian will agree with you that just because technically you could slip through several doors that happened to be not locked and got helpful advice from a neighbor, it doesn't mean that whatever you found behind those doors was "public" just because you didn't have to pick locks. Or that the photos you took of private company documents by social engineering your way inside must clearly be unsecured and publicly distributable because "they were given to me when I asked for them".
> But I will say, by the same authority that tells you it's not your right to take other people's lives, even if they want you to kill them. Not yours to give,not yours to take..

> ...is your life your own even though you didn't create it and didn't raise yourself?

Other people's lives are their own. You seem to imply that because one doesn't chose to be born and cannot raise themselves that they don't have any right to chose to die. Then who does? Their parents? Some mystical sky being?

You're entitled to your own beliefs, however vague or fantastic they may be. Having spent a few decades being indoctrinated with a fear of an eternal hell (without any evidence) I'd rather not entertain such foolishness anymore.
If it gets too slow you can always squash migrations. But since Django 2 I haven't seen the need to do it, runs in a few seconds even with hundreds of migrations.
This was also a sales pitch for Steam – especially in developing countries where the whole concept of paying for non-physical things was a hard sell.

(Though in this case it wasn't just competition – access to official servers in online games was something that was often not pirateable.)
Epic Games unveils $1.78B funding round at $17.3B valuation
This is not a useful anecdata-driven analysis of the commercial real estate market. Yes, landlords like the ones you know do exist. They do not own substantive commercial real estate, and certainly not the stuff the Neiman Marcus or GNC have been renting.
A company I know insists on rotating passwords fairly often. Everybody just increases the number at the end of their favourite password, i. e. intel1255
"we know you are using
[nightly] for your project because we gated all the features behind it"

yes, that kinda sucks.
I'm not sure you can even consider it "breaking in", it's more like tweeting that under intel.com/super-secret url you can see some internal, secret documents.
Unix-stuff as a part of the standard library is a terrible idea. Making your own crate is simple enough. Same with OS-dependent functionality.

Re: crates namespaces, that is a crates decision, not necessarily Rust'. You can always publish your crate on github and include it with "package = { git = ... }" and you'll get the same thing as in go.
Would you be willing to expand on why using strings for file paths turns out to be unworkable? Very curious what the obscure reasons are!
Would you say the same about for loops? Depending on your audience, it's totally reasonable to expect they know certain things. Further, figuring out what to recommend isn't always easy, and I'd usually rather authors put their efforts into presenting the material that they have to share.
Show HN: PDF Converter API
Just logged in to say that a war has little to no potential strategic benefit to US and its allies.

It has several, yes, lots of downsides. Nothing like WWW3 (that's so XXs), but China will probably take the chance to hit hard, taking a long time toll from the US infrastructure, if not in US mainland (highly unlikely if they don't want to have theirs bombed), probably overseas.

They'll clear their way in, into several markets / territories, currently out of reach because US fully control them (South Korea, Japan, Vietnam, Taiwan, but some African countries could easily be added to the list).

War is not really a good idea for US.
I see I replied to that tweet - it's a great list of criteria.

> What are the current scaling limitations of Supabase?

We haven't benchmarked it yet, but we have one of our power users doing ~1M API calls per week. That's on a t3a micro server. Soon, we will give you the ability to scale up and out. We don't plan to abstract away the database layer too heavily because it break the "no lockin" promise. We will more likely make it very easy to run a High Availability cluster (Ant has a background in HA).

> Are there any plans for a typed/generated client down the line?

100%. We're planning a Supabase CLI which will do this (+ give you the ability to spin up new projects etc).
~? gets you a list of options
~. terminates the connection

Sometimes plain ~. just doesn't work, depending on what state your connection is in.
I worked at IBM research from 1997 until 2007, after finishing my PhD in compilers and programming languages.

About two weeks after I started working there, she showed up in my office, and introduced herself. She'd heard about a new PL person joining, and she'd gone and gotten my dissertation and read it, so that she could come talk to me about it. Not that my dissertation was anything special: that's just the way that Fran was.

She was an amazing person. Brilliant, and kind, and generous. The world needs more people like her.
You just gave them money. They didn't coerce you. It would be different if they flashed a weapon.
Inflation to the rescue? If rents decline in real dollars but go up in fiat dollars, does it resolve the situation where renters can't afford rent and property owners need a certain profit?
What things does it do besides update the schema, or run a custom python script?
I think you're confused. The old law that we had that already forbade prioritization was the Title II, and that's what Wheeler classified Internet as. Pai basically reversed that decision, so it was a step backward.

Wheeler when he classified Internet as Title II, made exclusion that ISPs that currently have infrastructure are not required (under Title II they are) to lease it to competitors. We don't need 10 different fiber wires coming to our house, since most likely we will only use one, all we need is to be able to chose between ISPs and that ISP can reuse existing infrastructure, kind of like it was with selecting long distance call provider on land lines, or ISP on DSL (which was automatically under Title II already, do you remember how much competition was back then? if you had phone line from PacBell, you didn't have to have internet from them, we had sites like dslreports where people could compare and chose the best one).

What residential Internet needs, is separation of the last mile with the ISP (kind of like it is in data centers, you have separate company that maintains all wiring and separate company that provides service).

Since neither FCC chairman wanted this simple solution to enable competition once again. We need consumer protection, and this comes down to net neutrality. NN forbids ISPs from interfering with the service, that's it, the California law basically reinstated those protections. We desperately need them because the "propaganda" is not far from the truth. Just look at the latest acquisitions. Comcast now owns all content from NBC Universal, AT&T owns all content from TimeWarner. Why would ISPs enter this market if they wouldn't see some benefits of their current position. Now they are already bundling those services together, and with lack of net neutrality they can prioritize their content over others. Why did we even allowed to get to this point?
I read it a little differently. The author steers clear of debating causes of symptoms and speculating how high or low FP% might be. He even doesn't quite come out and say Covid-19 is a "pseudo-epidemic" though one could easily infer that from the title + subheading.

The main points I read were:

- A FP cannot logically be determined using two non-ground truth tests (PCR)

- This means FP rate is unknown

- Even if the FP rate is low (~2%), it would mean perpetual epidemic given current testing targets

- Public health officials and policy makers don't understand the data and/or aren't incentivized to consider the cost of lockdowns

Though it was be nice to hear from mike_hearn himself.
Right but there’s no organization devoted to extracting blood and throwing it away.
SpaceX using $3.6 billion investors money to build Starship.

It will probably circle the Moon before NASA SLS.
And they could do even better technically and have "MS Excel" be implemented on top of MS Matrix using an extension framework. That'd really firewall the cruft and encourage the core program to be flexible.
> Closed-world ("sealed") traits. Rust's rules against private types in the public API are good civilization but they make it difficult to define pseudo-private traits like Mount that I want users to name but not implement or call into.

Rust actually supports sealed traits by using public traits in private modules. See this for how to use it, and how it works:

https://rust-lang.github.io/api-guidelines/future-proofing.h...
They return exactly the same thing: either null or a node or node list depending upon the method in question.

Any number of reasons like what? Could you provide an example of what would make those methods that much slower?
Curious which applications require logging at high sample rates vs. doing event-based?
Whenever I see someone claim a given problem is due to a combination of factors, I get a bit suspicious. First, this seems like a way to say "I don't really know the actual cause." Second, in the real world in situations like these, there is almost always one overwhelming factor that accounts for >60% of total influence. I really do wonder what that is because I like insects!
One could make an argument based on what we've seen during COVID19 so far that very large sections of the US economy are not genuinely viable. They've been fabricated out of the whole cloth that we call debt, they have almost zero resilience in the face of negative economic factors, and they participate in widening income and wealth inequality by not actually being the locus of viable family-supporting jobs.

Nobody has wanted to acknowledge that so much of the US economy is a house of cards. COVID19 isn't forcing people to do so, but is making it much clearer.
> “We’ve learned how to make better blades, and now we want to do it.”

Unfortunately this is at odds with the interests of blade manufacturers, so I doubt we’ll see better blades anytime soon - at least from the current manufacturers.
Just block port 53 in your firewall
This is me. When I stay at cheap hotels that have bogus reviews like “small room”, I’m very inclined to leave more positive and realistic reviews, and even to be more understanding of them. Usually this leads to being treated better and it’s a win on both sides.
In the U.S. town and city budgets have a pretty steady lighting investment component.

Because LED’s got so inexpensive, instead of saving money, the savings was used to increase the town luminosity.

Now, because we moved away from sodium lights, the amount of daytime-like blue light being emitted during the night has skyrocketed.

Wups
It's very divisible because (as i understand it) Gold can be reformed back into larger units after broken down... whereas some things (say diamonds) actually lose value as they're broken down. a 1 carat diamond is worth less than 1/2 of a 2 carat Diamond.

i've seen it go down to 1g of gold for ~$90 in today's prices.
Did it many years ago. Would do it again.
How hard is it to learn how to draw your own blood? eg. what the nurses do when you give a blood sample for lab tests.
Business logic ports over really well - we have been able to effectively copy and paste code and the corresponding tests between a legacy .NET Framework WinForms app and .NET Core 2.0 and later service (WebAPI or gRPC) and it mostly just works. The trouble comes when the code integrates heavily with a UI stack - that’s a lot more work to port over. It was pretty hard before .NET core 2 though. But .NET 4.8 will be supported as long as Windows 10 is - probably at least another 10 years or more.
There was a lot more regional and even local independence in the economy when these happened. Vastly more people still worked in agriculture, and economies produced far more of what they needed within much more limited areas. 1929 was bad, but the economy then had more of a "node" structure. Today, it is more of a "web", and tugging hard anywhere stands a good chance of pulling the whole thing apart.
Why not get a 4XL?
Insects are dead because we manufacturer billions of liters of insect-killing liquid to spray fields to feed billions of humans.

Starvation levels have dramatically declined over the last century.

Now, we need to fix the problem we induced in our goal to feed the world.

The only known solution is vertical farming.
> "autistically"

I think many of us would appreciate it if you did not use autism as a negative label.
...They won't starve or be on bread-lines....

There were miles-long food lines already by April:

https://www.nytimes.com/2020/04/30/nyregion/coronavirus-nj-h...

https://www.businessinsider.com/americans-wait-in-long-lines...

https://www.motherjones.com/food/2020/04/these-photos-show-t...

https://www.npr.org/2020/04/17/837141457/thousands-of-cars-l...
Nvidia tries to get its hands on Arm
It can suffice, but it will never be ideal.

I had a project just a few weeks ago where somebody tried to do that and hit a brick wall nearly instantly because one table had an array column. SQLite instantly became useless.

IME unrealistic tests bite much harder than slightly slower tests or needing to install the odd bit of software. Realism is pretty much the only thing that gives you confidence you'll actually catch some damn bugs...
The asm!() to llvm_asm!() was a pain.
Wouldnt you load appropriate polyfill bundle based on Browser UA string anyway?
How long will that be the case? This seems quite obvious if people have to stay home. The main problem with Uber is the low barrier to entry and brand loyalty. Uber has left the market I am living in and except the color of the app it did not change anything to my life.
The idea that some library can abstract away database concerns to this extent is wishful thinking.

You inevitably need to understand the SQL that your ORM is generating and what the database is actually doing. Otherwise you're flying blind.
If your String type must be valid Unicode (which is true for pretty much every language that isn't C++), it cannot represent all paths. On most unixy filesystems, filenames are arbitrary byte sequences which aren't valid UTF-8, and on windows, NTFS stores filenames as UTF-16, but it allows unpaired surrogates.
The fear of robots displacing workers has returned
Where Big Tech criticism goes wrong
> I guess I expect rustdoc and rustc to be much less tightly coupled

Yeah, and that could work in theory. The thing is, rustdoc uses the compiler as a library, so they actually are pretty tightly coupled. This causes a lot of pain but also has a bunch of upsides. I really want to see a rustdoc that is not, but it's gonna take a long time.

> That's correct.

Cool, I thought so, I just wasn't 100% sure! I think it's interesting how different people take away different things here, to me, this demonstrates that you don't have to have namespaces; many of the largest ecosystems do not and have not had them. We did learn a lesson there, just didn't come to the same conclusion that you did. This one is more controversial within the community though, many people do agree with you.

> Given a crate with a hundred files

Yes, but that doesn't change with rustc vs cargo though; it's still a single rustc invocation to compile all those files. (And, it doesn't quite do so, there is some degree of incremental compilation going on, but it's not as fine-grained as it can be. Working on it!)
R&D work mainly.

To understand the duty cycle of your products (let's say a tire) in the field.

To collect data to train ML models or to develop algorithms.

Use as a prototyping platform for IoT products.