skysight-inc/HackerNews huggingface dataset:
There are many reasons why it's not as easy as the article lays it out:

- Especially for drugs, if they interact with core mechanisms that are common to many eukaryotes, they might interact with the yeast itself, and possibly inhibit their growth too much

- If you know a organism that produces your desired product, you first have to discover the pathway it uses to produce it. This includes discovering all of the proteins involved in the pathway, which isn't always straightforward.

- If you can't construct a pathway from existing proteins, things will become a lot harder as you now also have to design a new protein to do the job. Our ability to do that is still quite limited (as it's somewhat blocked on protein folding prediction like many things in biotech).
Keep dreaming.

UBI makes families even less relevant.

You need something? Contact your friendly government office.
I mean, in Wirecard prosecutors literally went after short sellers with criminals charges. For years. They only dropped charges a few months ago after a donation was made to a charitable organization. Seems pretty similar and pretty corrupt to me.

https://www.reuters.com/article/us-wirecard-accounts-germany...

edit: I guess "we'll ruin you and throw you in jail" is better than "we'll throw you out a window" but it's still pretty bad.

edit2: And if Wildcard hadn't imploded there'd have been no scandal about prosecutors going after critics. No issues with silencing complaints or limiting freedom of speech. Just another part of doing business against companies the government support.
Influenza viruses don't have that mechanism.

That doesn't prevent humanity to have working vaccines each year for the currently important influenza viruses. The needed research was already done long ago.

But regarding SARS-CoV-2, it's still too early to say anything for sure, we have lost the precious time in not learning enough from the properties of the (2003) SARS-CoV virus, not to mention western world remaining very unprepared for long after the spreading of SARS-CoV-2 started.
Show HN: Longtweet.io – a use case for on-demand static site generation
Show HN: First Look Demoing Sentien Audio Noise-Cancelling Microphones [video]
Ask HN: What's the best way to start learning about / playing with GPT-3 and AI?
I've seen _awesome_ breakthroughs surrounding GPT-3 on Twitter, and there always seems to be energy in AI, but it feels like the field is impossible to start working on.

I'm not necessarily looking to deeply understand the math and technical details behind these algorithms, but want to learn how to play with them and find the limitations. I find there is little easily available on the internet that is between
1. Type in these commands and everything works perfectly
2. Read this obscure paper

Current situation: Recent college grad from Vanderbilt U, found a month between contracting as a SWE and starting as a PM at Microsoft.
Twitter is not as profitable as they want to be, so the corporate wants user to do something monetizable, but users prefer what can’t generate revenue and don’t favor whatever that do, but Twitter is a private company so they have to do it eve if it would only result in its irrelevance, and that will lead to even less profit, then
This is one of those ideas so great they seem obvious.

Anyone knows if there are any stable implementation?
They still got hope, I guess? :D
What you’re describing is common and you can recover, I recommend a book called DARE - it changed my life.
Google kills off Microsoft’s RAM-saving feature for Chrome on Windows 10
I am in Canada and it seems to be available.
Hardly anybody outside of the tech bubble saw those videos. What happened there is a brigade of haters came along and down voted them. Probably a lot of Mozilla/Google supporters.

There are plenty of Microsoft videos with mostly upvotes. Try a video about the Xbox.
Also, it takes a heck of a lot of rocket fuel to just throw a probe at the Sun. More than to send it out of the solar system.
Factory farming of animals is disgusting no matter if it is chlorinated or not - and this is coming from a meat eater (trying to be a vegaterian).

Perhaps some good will come out of this, and people will start to think a bit more about where their food comes from and how it was made.
This is the true value of short sellers to the market. They were blowing the whistle on Wirecard for years before the regulators or company insiders did anything. The problem is they always look like fools while the company valuation goes up but then get vindicated all at once when it collapses, if it ever collapses.
I would love to be able to do a "slow search" that let me use exact strings.
Cobbler here, currently cobbling a frontend (am a backend dev by trade).

The issue for me is the format these courses and resources take. CSS is the most jam packed with non-intuitive technology I've met. How many dozens of pages or segments of video would I have to go through in a course to learn what the author in OP summarised in two or three sentences? Any time I've considered the structured approach for something like CSS, the material drones on and on with technically correct explanations and example code, but somehow against the odds, almost nothing of substance.

Worse yet are the top google result reference resources. Look no further than the top result for "css grid" if you're in the mood to claw your brain from its stem, and flush it down the toilet.

Link: https://css-tricks.com/snippets/css/complete-guide-grid/

Behold, 8 zillion words and symbols across 7 trillion seemingly randomly organised boxes full of both all of the information, and simultaneously none of the information, about css grids.

Which brings me to where I am now, cobbling. It's more effective for me to cobble, than to spend an entire day figuring out css grids "the right way". If the going gets tough I'll just use some grid tool, or look up some sandbox examples, and be on my way.

If there was more material like the OP, and someone organised it well, well, I'd actually get around to learning it rather than cobbling. It's the best bit of writing I've ever seen on CSS. This is shocking. Not that there is anything wrong with the writing, but it's very, very simple. What on earth have all of the other CSS wizards with basic writing skills been doing? Confusing the issue, that's what.

Which leads me to a sort of meta frustration with learning CSS. I know it's not hard, I know that if someone just wrote about it even half decently it would take only a moment to digest each concept, but watching learner-disconnected authors create resources I can tell have lost sight of what it's like to learn, turns me off.
>If you're on the DAX or a politician, you're untouchable in Germany and lots of people inside and outside of Germany have no idea of how insanely corrupt the German government and their corporate buddies are.

This generalizes to damn near every government (or any big powerful organization to some extent as well) ever. The only difference is that more money enables some governments to abstract it away and reduce the visibility of it better than others.
Thanks! Wish I'd caught it in time to fix my 1st comment.
There is a definite energy advantage to being very small. When I was working in the proper nanobot space it became quickly apparent that "gray goo" was nonsense. Bacteria are grandmasters at throwing away things they don't need. In fact, due to epigenetics, many bacteria don't even contain all the genes they need to survive in their own environment — the cost of maintaining the complete set of genes is distributed through the local population. The corollary is that anything that's small is limited to doing things "like a bacteria would". The only way around the energy barrier is to pump energy in from an outside source; y'know, like plants. Notice that plants don't get around very much because their energy source is pretty scant. Just "dumping more energy in" doesn't really work because the energy scales cause (what we called) 'spontaneous disassociativity of functioning parts'.

Personally, I think the real breakthrough was LBL-silicon turing complete silicon nanoparticles. They combine the best parts of nature (proteins) with the best thing we've though of (computers) to provide a pre-defined library of additional capabilities to the host organism.
>But don’t be fooled. The world’s economies are moving away from fossil fuels.

There is absolutely no evidence for this, and much to the contrary. Global CO2 production, which is a good proxy for overall fossil fuel use as steadily risen [0]. This comparison is limited only in that it fails to show that switching from coal to LNG does decrease emissions while doing nothing to change reliance on fossil fuels.

The dip in emissions and oil production that happen with the pandemic demonstrate very clearly that emissions and fossil fuel consumption are directly tied to our economic activity. Since our goal is to resume to "normal" as soon as possible global fossil fuel consumption will get back to "normal" as soon as our economies do (now what plays out there is an interesting question).

Bizarre that the Economist can make an assertion like that and people swallow it without question.

[0]. https://www.iea.org/articles/global-co2-emissions-in-2019
Datadog has incredible integration with clouds (AWS and other), databases (postgresql, mysql, cassandra) and middleware (haproxy, kafka). It can capture all the metrics from all these out of the box with minimal effort, whereas you have to crawl hundreds of broken plugins for prometheus to get one third of that.

If you're using clouds (AWS/Azure/Google). Datadog can capture all the AWS metadata automatically and merge with existing metrics, so you use instance tags and such for searching and filtering. It can also capture AWS metrics like ELB and S3 usage which are hard to get otherwise.

So you simply get all the metrics you need and get them easily (I appreciate that people who haven't worked with these probably can't fathom what they are missing out). There are defaults charts/dashboards that are quite good and available out of the box, whereas grafana is empty out of the box and you're once again forced to crawl for dashboard plugins.

Last but not least. The capabilities to search and visualize in datadog are incredible. To draw any metrics and combination of metrics in different ways and analyze usage. Prometheus can't chart shit. Grafana has limited charting and you're forced to create a dashboard to make one chart, which can't be done because don't have admin permissions.

By the way prometheus doesn't scale. It can reach 1000 or 2000 hosts top and that's the end of it. I've operated it at the limit, some operations get really slow and we had to cut down on tags and some metrics to avoid crashing.
"80% of the basic functionality"

Is this a desktop functionality oriented post or something? Because there are things I find daily that can't be done with Windows Server, but come out of the box on most Linux distributions. Mostly storage, monitoring, or networking related-- aka some of the most important things.
What hurts Thunderbird extremely hard is Mozilla's inability to keep any embedding story live for more than a year or so.

Originally, Thunderbird and Firefox lived in the same CVS codebase, and the only difference to build Thunderbird was changing one line in your config file. When Mozilla moved to Mercurial, the Thunderbird code was left out of the repository on purpose, and so gained the annoying split-repository. Then Mozilla removed the ability to build the C++ code in anything other than a link-everything-into-libxul configuration. (Well, you could choose to have binary components live elsewhere, but the string APIs turn out to be completely different for pretty much no good reason--and mail code is obviously very string-heavy)

There was a plan to build Thunderbird on top of a vanilla XULRunner. Then XULRunner was killed off. Webrunner was next (I think), and that was then killed off again. Now I believe there's yet another thing, but of course Firefox has also shut off access to binary (C/C++) extensions, so if Thunderbird wanted to use it, it would have to rewrite ~1M lines of code.
But it's not how long they've been around, it's whether they're built into standard browsers. Presumably, CSS variables can never be removed from standard browsers. They are permanently available in the web "toolchain". SASS can be replaced by something else. There will be workarounds, but it will probably be more of a problem.
I've been collecting Twitter scrapers recently with the idea that I might eventually do something with them. This one [1] seems most promising but I haven't actually tried it.

[1] https://github.com/bpb27/twitter_scraping
Amir rulezz!
Awws SES, sendgrid?
Based on your "also": According to the spiegel article the investigators didn't end up in a psychiatric facility, but got a diagnosis of inability-to-work and pensioned.

The case for Mr. Mollath was much worse.
The Microsoft Police State: Mass Surveillance, Facial Recognition, Azure Cloud
There are only 100 percents
Isn't $70.5k USD around €61k EUR?
Yea, at the very least couldn’t you just have something like a windshield wiper periodically wiping the sand away? Or vibrate it so the sand falls off?
How to Block Numbers from calling/texting you
Try BlockBear for Safari on iOS.
Why you should have a blog (and write in it)
Around the point in the interactive where it shows how the virus swings sugar molecules around to distract the immune system I paused and marveled at the tiny universe inside our bodies.

The first time I recall feeling similarly was when I first watched Cosmos as a kid, and Carl Sagan juxtaposes time lapse photography of cities against the bustling activity of cells inside the human body.

We walk around every day thinking of ourselves as solid objects in a Newtonian world, like balls on a billiards table. But when we actually take a minute to reflect on all of it, it’s clearly so much more complex than that.
Is it supported? I tried to add a secret key on a smartcard, and it failed
Facebook Beats NSO’s Attempt to Crush WhatsApp Malware Suit
That paper answers my first question, does neurological tissue have ACE2 receptors. The damage can also be a side-effect of oxygen deprivation. The existence of ACE2 receptors in the brain begs the question of how the SARV-CoV-2 virus crosses the blood-brain barrier. IIRC, dental surgery has been correlated to pathogens crossing the barrier. I wonder if that is a key factor here as well.
I recently jumped from linux mint to Fedora...just to play because i haven't lived in anything related to redhat for many years (no offense to fedora or red hat, just formed a habit of ubuntu-derived distros like Mint)...anyway, i've always been a tunderbird user, but now that i am trying fedora i set it up with KDE...so figured I'd try kmail - which i had heard good things about. Well, my experience was ok/so-so as compared to thunderbird. Please don't interpret this as some start of a flamewar...i don't hate kmail by any means...it just felt like it was a similar to thunderbird but i don;t know less polished or with fewer features that were exposed. I'm sure that i have to give it more time to be fair, but so far kmail has disappointed be a little bit. I'm going to continue using it to see how things go. (Obviously my experience is not based on any evidence, nor is a formal review or anything like that...just early usage feelings.)

EDIT: I should have added that as much as i use (and admire) thunderbird, there are many gotchas, and it could benefit from many more adjustments and fixings. Also, i do like to live in a world that has choice, so I would be overjoyed not only for thunderbird to improve but also kmail and all other open source email clients. The more, the merrier!
Transgender track stars: Losses prove girls sports lawsuit faulty
>At the same time, the low barrier of entry and hype has resulted in a huge amount of people downloading Keras, copying a bunch of code, tuning a few parameters, and then putting their result on arXiv so they can put AI research on their resume. This has resulted in so much noise and low quality work that it really hurts the field.

I'm sorry but given that many papers in NeurIPS, ICML, etc are exactly what you described I find your criticism a bit lacking.
Money and equity are not culture or especially family. You find out your real family when you are down and out. Those that still care for you when they have no incentive to are your true family. Not the people who only stick around when things are great and glorious.

Generally speaking, there is never a "family" in a business. You are all there to make money, period.
Infinite Oblique Strategies with GPT-2
Limits seem to be in the documentation on per resource-base.

https://developer.twitter.com/en/docs/api-reference-index

Or is this the old documentation?
I don't think you're aware of all the details here. The special purpose vehicle also structured a transaction with Credit Suisse which effectively allowed the bonds to be resold immediately to institutional investors. The fund (i.e. SoftBank employees) had no ongoing risk exposure and pocketed the pre/post-deal spread in the share price.

Matt Levine has an article about that on Bloomberg: https://www.bloomberg.com/opinion/articles/2020-07-02/free-w...
Creating a Wireshark dissector in Lua (2017)
> People are not looking for trusted sources of knowledge. They are looking for entertainment.

Which people? Whose people? This is not a statement of psychological truth. It may however describe a societal truth.

But it is not true that people in all countries want above all to be entertained. People struggle in undemocratic countries. Education makes democracy strong. It also breeds rebels.

Public discourse reflects education. A society conditions its citizens to think a certain way. The typical conditioning involves protecting the society. The flag, the anthem, the history, the current power structure and its wars.

It's sad to see journalism collapse in a democracy. It's sad and perhaps fatal for democracy if people have been conditioned to be infantile and their implanted desire for gratification has overwhelmed their thinking and speech.

Then you elect them.
Most importantly none of these items, except maybe threads require a new API. Poll results would just be added to responses, pinned tweets would be a new flag to the search endpoint and a more powerful filtering and search language can just replace the search API. It seems weird that they are tearing it all down and forcing everyone to migrate.
Would you rather have a non-disparage agreement or $30,000?
Machine learning insight saves 250k tonnes of shipping CO2 emissions
The drawer component doesn't seem to work in Firefox 78. Clicking on the buttons to open the drawers doesn't do anything.
People praise the government for the stable economy, attributing this to competence. The truth is (in many economists' opinion) the stable economy is because of the bad construct pegging the European currencies, probably not because of good governance.

Sorry I can't provide you with proper up-to-date citations, but you declaring "that's not the case" does not make it the case. Well, me declaring "that is the case" does not make it the case either.
A bit tangential but I recall working with a company that wanted to use a particular very expensive brand name closed source software framework to build their ecommerce site. The going price on using this was in the half million ballpark. Working with this framework I was incredulous that anyone would actually want to buy this framework -- also none of the sites I have seen built on this actually work very well. But the force of the brand name and the audacity of the asking price just seem to mix well I suppose. If you are in a corporate setting with little technical ability, and more money to spend than brains, 'you won't get fired' if you choose to go with vendor X (not IBM but point stands) -- even if vendor X is going to fleece you of millions while providing little value. Its just the safe thing to do.
Front end development is a craft, just like other crafts. People need to treat it seriously if they expect to be taken seriously and be paid accordingly. (BTW, if you still haven't met a FE dev who's ever read a book on CSS, you have now. I own quite a few AND have read them.)

I also think a lot of the value from a front end developer comes from their ability to merge the technical requirements with a designer's vision, and produce a product that is at the same time usable, accessible and (bare minimum) meets the technical requirements.

Not going to touch the CSS Grid except for two quick comments:

- they absolutely should have been keeping up with CSS Grid, where it was at, and when it was usable and when it isn't

- it is still an open question, because although the overall numbers should 90+% available in browsers, you have to check your own stats. For example, the stuff I work on is often used in Enterprise environments, so IE11 is a requirement (yes, we know our numbers, it is, it could literally cost us 6 figure sales if we don't have support for it). We are using CSS Grid, but we have to be very careful what we use it for and to test those uses in IE to make sure the old Grid spec in IE supports the things we do it with. Otherwise it's back to Flex or other layout techniques. It's not a silver bullet, but I also recognize that is becoming a more unique example these days.

Those are the kinds of things a good FE dev should know though, IMO, and be able to articulate.

Plus, FE devs also need to know HTML and semantics, accessibility, and of course, Javascript. When you can put that all together along with the skills earlier re: usability and accessibility, then you can justify the higher salary brackets.
BTW this is why arrest records are public in the USA. The British would arrest people and their families and friends couldn’t tell what had happened, so as a result you “can’t” be secretly arrested.

I put “can’t” in quotes because of course there are a bunch of ways the rules get bent and twisted, but I suspect the number of arrests unreported by 24 hours is pretty close to nil.

OTOH the system has adapted to this constraint: since they have to be reported anyway the police have inverted the sense and adopted the “perp walk”, which prejudices the accused’s chances in court right up front. And of course extrajudicial punishment skips the whole apparatus in the first place...but that can happen anywhere.
Private Pilots Get Their Chance to Fly into Major Airports
You're right, I mixed up. I edit it.

Still, €61k isn't an average salary. An engineer reaches that after about 10-15 years (from personal experience and some statistics I have access to). It's double the national median.
Iran state hackers caught in intercepted videos
At the past 38C3 congress there was also an interesting talk about how the main political parties influence the German public broadcasters.

No surprise there is so little critical reporting, despite the 9 billion euros yearly budget.
Last time I checked (2 months ago, I think), the API couldn't fetch more than the 3600 latest liked / posted tweets. Has this changed?