skysight-inc/HackerNews huggingface dataset:
> How come, since we know so much, not produce a mechanism that counteracts the virus?

The virus hijacks existing cellular mechanisms for its own purposes. Interfering with those mechanisms could halt the replication of the virus, but it could also kill you. As an example, the virus enters cells through the use of the ACE2 protein. That protein plays a part in regulating blood pressure, so you can imagine the danger that could come from doing playing around with that.

However, SARS-CoV-2 is an RNA virus and its genome codes for an RNA polymerase enzyme that copies its RNA genome. Human cells do not use RNA polymerase and so it could be a target for a drug. This is how remdesivir works, but you have to find a compound that can effectively interfere, but that isn't too incidentally toxic to humans.

> I suddenly got an urge to learn how I can program proteins to do the stuff I want to do. From reading material around proteins, it seems they are nothing more than mechanical devices.

Good luck, I'd argue that our ability to design functional, non-trivial proteins de novo is essentially non-existent. The function of a protein is highly dependent of its shape and the process of how a string of amino acids folds into the final shape of the protein is extremely complicated and requires supercomputers to simulate. Not to mention that proteins may require help from another proteins to properly fold. Proteins may also be modified after they have folded and a lot of proteins require things like metal ions or other cofactors to actually be functional.
I'm also wondering about the initial point, but ...

Is there ever a best tool for _everyone_?

I have only ever been convinced that something is the best tool for a job, when taking into a account a lot of context, exact requirements, available resources, etc. Otherwise you are almost always left with quite a large number of options that are equal for the information available and you can basically choose from by rolling dice.

Regarding 2) I think it goes beyond comfort zone. I have seen plenty of completely chaotic, unmaintainable code bases due to the initial developer(s) starting the project without any prior experience of the technology. Of course many paths lead to chaos, but I would wary to start anything time critical in something too different to what I'm already quite comfortable in
that's a good word. I'm going to use it in my enterprise sentences
Maybe she should step down, so she can focus on her health?
No, a company such as Sony Entertainment or the like that takes all of the ad revenue from a melody that vaguely resembles a copyrighted song.

Yes, that happens.

Otherwise, there's no issue with YouTube getting add money.
Permafrost in the Artic circle is shrinking, and it also affected methane emissions there. [0]

[0]: https://www.cnn.com/2019/10/12/us/arctic-methane-gas-flare-t...
It's disturbing that it's even legal for essential services like paying for things and receiving messages to be intercepted and data mined for entirely different purposes by arbitrary third parties.

(I assume this is in the context of somewhere like the USA, because it would very clearly not be legal under privacy laws in places like Europe.)
I would vouch for Imagineering Story as well. Great mix of technical stuff that's awesome from a nerd perspective, while entertaining for the non-techies too.
It seems wrong to list his Occupation as "Victim" in the wikipedia article.
DJI, who makes the majority of consumer drones, has already implemented broadcast-based radio ID, but that's not what the FAA proposal suggests and is not the part of the regulation that is being criticized.

In fact, the FAA has explicitly stated that they don't want to use a radio-broadcast system like ADS-B (the equivalent for general aviation). The solution being proposed involves a proprietary internet-based system that has privacy/security implications among other issues -- The system would send the location of any user to a third-party company, would require a subscription, etc.

The solution does very little to alleviate the concerns you are discussing and many more reasonable proposals have been suggested which DO involve radio ID. My favorite solutions involve a combination of a radio beacon broadcasting GPS and registration # in the style of ADS-B for larger drones/aircraft, and for smaller aircraft an app-based system where users "check in" with a flight plan. But keep in mind that the outrage is not over any regulation by the FAA, it's that their proposal completely disregards existing industry standards like those put out by DJI and creates an expensive, hard to enforce system that favors large corporate interests.

Let's keep in mind that there are millions of drones in the US (1.1 million registered with the FAA, and many more that have not been registered because they are <250g or custom-built.) and have not had a single incident involving injury or death. Every single incident involving a drone has involved the concern of violation of someone's privacy or violation of an airspace, and even in those incidents there has been a lot of hysteria involved in the media response. In my opinion this absolutely does not justify preemptively building an expansive surveillance infrastructure around technology that has, so far, proven to be very safe.
I've been using it on my Android phone for over 3 years, while always being signed into Google. Never had any issues.
I have tried NewPipe, but I guess I'm not its target user.

I use YouTube frequently, but I almost always just watch my subscriptions.

By not having a login system, it is basically rendered useless despite how nice it is to be ad-free and having a much cleaner UI

(I knew you can import subscription, but I sub and unsub channels constantly so it becomes a pain very quickly.)

I'm currently using YouTube Vanced instead.
but radio ID wont stop bad actors...
Building a Weather API Dashboard with Flask
Dexamethasone in Hospitalized Patients with Covid-19 – Preliminary Report
Anecdotally I have heard that a lot of commercial projects have recently been suspended so there are also more construction works available for residential work.
Hey, really good list, better than the article.

I don't really like PHP, because of inconsistency (it tends to break to flow for me) (but maybe it changed since 2014), but php with strict typing is a big plus for me and php7 is already more than fast enough. I might try it again.

The real issue i have with PHP is frameworks :/

Too much choice is a productivity killer for me.
I understand that, in some sense, this may be true. But notice that it doesn't say that not being grumpy is a recipe for failure.

I personally prefer to be good-tempered and not grumpy, and I am rarely in a bad mood. I call this dog philosophy.

It probably means that I won't have all the success and greatness and stuff that others have, but overall, I am much more content seeing the world through rose-coloured glasses.

My dog seems to agree.
I don't know solution for the entire IT industry but can suggest something for Corporate IT:

New IT staff should be given grounding in Business Curriculum relevant to the Corporate's business / Team's mandate - this ought to organized by upper level of IT management.

Software Developers / Engineers working in Corporate IT tend to stagnate in terms of their careers once they hit the wall (wall = business knowledge).

E.g., take an investment firm and within it, say IT Department XYZ Supports the firm's Private Equity investment team. It is easy for Software Engineers in the team to code up and provide Tech. solutions however for complex business cases where advanced Private Equity knowledge is required, the Software Engineers have to rely on the Business Analysts or the clients themselves to do hand-holding.

I have only seen something like 1 in 10 Software Developers in Corporate IT willing to pick up Business knowledge beyond the basic business terminology. And this is why I believe the value of Software Engineers at Corporate IT takes a serious hit - from CEO / Board / Upper layers of Finance, it looks like the drivers of revenue are basically their finance folks (CFAs, CPAs, Investors) whereas IT are just a cost center to enable the finance folks to do their work (which is a very bad vision but that is how it looks like from their POV). In these cases, the only group from IT that benefits somewhat are the top IT management who act as the guardians of the IT division.

Another thing that works against IT folks in Corporate IT is self-criticism (critical of current IT culture, constant itch to reinvent self), constant need to associate with low-paid/ low-educated professions (factory line worker analogy, plumber mentality) and appearing far too casual. Sure, jeans and T-shirts and having eccentric/artistic personality is the culture spawned from Tech stalwarts based in Silicon Valley, but that mentality does not translate into rest of the World. Even if the Corporate's HR policies allows for dress-down environment, guess what - the HR and Finance People typically appear well polished in their appearance - they rather have nice office lunch rather than pizza and pop chow-downs and you can't deny that as humans (especially if the CEO and top Execs are non-IT), it doesn't leave a very favorable opinion about the IT staff.
The entitlement among the general population is a little nuts. We expect things for free, without ads, and with high reliability. In this case we also want additional features like not logging in, downloads and background playback. Side note: Is it any wonder that journalism is dying when no one wants to pay for it (or be subject to advertising)?

YouTube is asking that their users either watch ads or pay money. That's how YouTube and creators can keep the lights on. I think that's a fair model. There are other models, like Vimeo, where the uploader pays for the hosting.

It certainly seems like the future is one where we expect access to everything and pay for nothing. That worries me.

/soapbox
Anti-mask people are non-violent in comparison to BLM and Antifa. There were six murders inside of Seattle'a "autonomous zone" including two minors. Anti-maskers aren't burning city halls, throwing Molotov cocktails into police cars, destroying public and private property, etc. There is no equating the two.
I think they were doing this in New York back in may, and it did yield some surprising results that influenced policy. Not sure if it was just antibody testing or PCR as well.
cool, i peeked at svelte when it was posted about on hn before, and liked what i saw in the few minutes i spent on it. i should take a deeper look.
How did he know they were federal?
Not that it addresses paying for the infrastructure, but many of the creators I watch are now reading ad copy within their videos and are otherwise sponsored directly.
>That's what I would ask BLM protestors making people kneel on the basis of their gender, skin, or job, in the same ironic tone.

"Making"? I don't think that's true. People are doing it in respect of black lives, unlike when people are forcibly being abducted by unmarked federal police.
If I remember correct suppesedly Walt said:"I dont get (stomach) ulcers, I give them".

But I fully agree on the CFOs spoiling the show: remember Tom & Jerry? There are (I think) 114 (great) episodes. Then at their creative peak the whole animation team was dismanteled, since they calculated they can make more money with reruns than with new content. Later there was a low quality reboot, though.
WOW there is a strange visual illusion for me, the red fonts seem to be sitting 3D <behind> the rest of the page
Exactly. This is why there's a goal for percentage of positive tests. We want to see a high proportion of negatives, because that means the virus is rarer but more likely to be caught in that population.
Cage – Kiosk Wayland Compositor
His whole schtick is "plain talk about enlightenment". I agree that it "sounds" egotistical, but if someone really had attained arhatship, and thought that the best way to promote spiritual training was to talk about it in a plain way, I don't think he's being unreasonable. And his lineage confirms his attainment.
China's economy looks very different if the world starts treating them differently. All while they're attempting to transition their economy from lowest-cost manufacturer to value-add.

It's benefited from 20 years of optimistic free market access.

No doubt they'll find trading partners, but it's not going to look anything like the open doors they've been used to. And they're going to start finding that their domestic and international choices now have trade consequences, rather than the look-the-other-way, laissez-faire approach the world has taken thus far.
No, my comment says that the two 2080 Tis would be better for convnets / situations where you don’t need to train Bert-Large. If you’re sure about memory pooling looking working for DL, please share code and examples, we would love to see one.
That's true of anything! Engineers optimize for a living. $ + labor ($$) = Output. It works when you grow, but gets expensive when growth slows. When the accountants come in, that's when the business is settling for (by choice or by market pressure) whatever they have, a little cheaper.

You see this with big capital assets in your personal life like houses and cars. Check out a cookie cutter subdivision new house with "builder spec" trimmings. The house is $600k, so they'll put in a granite countertop and shiny metal appliances to check the boxes and get the mortgage approved. But the light fixtures, toilets, etc are "builder grade" crap that are $14.99 at Home Depot! In lower price developments, the developers will skimp even more -- one near my house actually stripped and sold the topsoil! Imagine the corners cut inside if they were harvesting dirt for $.
Damn OpenSSL sounds a lot worse than I thought after reading those slides. The custom malloc, the function that allow you to jump anywhere in OpenSSL, the 17 layer deep IFDef, the dubious entropy that openSSL try to generate if the OS doesn't provide it, the bugs that sit in the issue tracker for years.

A lot of that uglyness seems to come from the fact that OpenSSL wants to support all environments (even DOS). I wonder why distributions haven't switched since LibreSSL was made to be API/ABI compatible with openSSL and target a POSIX OS. This would be much more justified than the ffmepg / libav thing imo.
The only thing that's stopping me from using these Youtube alternative apps is fear of my Google account being banned.
Have you written about your experience? I'd just be curious to know what you built, and the series of the events that unfolded.
> Those who grow up in a disaffected part of the US and go on to study EE or CS do so through a US college opportunity which will funnel them into a US semiconductor job

The probability of that happening is not so big considering people from such areas tend to have low quality schools around them, which tends to mean low test scores, maybe even involvement with the "justice" system, no real opportunity to land a semiconductor job.

What you said sounds nice, but I doubt happens much in practice.
For everyone wondering what's happening, here's my theory. They're likely using CCTV footage, either drone or fixed, to identify people in the crowd. Most likely these are instigators that are inciting violence or destroying property. They're waiting until the people are separated from the crowd, to make sure that things don't escalate, then arresting them.

We need to follow up with the arrests and make sure due process is being followed. If you're inciting violence or destroying property, you need to face justice. If you're assembling peacefully, we need to monitore for/end the abuse of power.
Ask HN: What are the Implications of GPT-3?
From what I've been hearing, it's a game changer.
Excited delirium is a very well-known and documented phenomenon, primarily in individuals that are on excessive doses of stimulants: https://en.wikipedia.org/wiki/Excited_delirium#Cause

However, nothing about its existence implies anything about police brutality. For some reason the article thinks it needs to deny the existence of something that obviously exists in order to argue against police brutality. This is a strange logical fallacy to commit, because you can easily argue brutality is bad regardless of what substances an individual is on.

Responding to child comments, it's possible that this condition is not unique enough to require its own name and label. But in that case, one can simply refer to the effects of doses of the given stimulants themselves, e.g. https://en.wikipedia.org/wiki/Methamphetamine#Adverse_effect....

Please note I'm not making any claim that brutality is okay or ever justified, just that there obviously does exist strong psychological and physical conditions that occur when an individual is on doses of very strong stimulants.
I avoid Tailwind-style CSS frameworks. I prefer SCSS and, if needed, mixins. Meaningful class names are much better, IMO.
When the CEO just says "We're going to spend X% on research, here is the budget" then they thrive again.

Incidentally, this is how OpenAI wound up in a situation where they might die in a few years. (Aka be acquired by Microsoft.)

The logic works at Google, Facebook, and Disney. Not so much for startups without a revenue model.
When I read that section about rems and ems and ch and px it made me think of Python's "There should be one-- and preferably only one --obvious way to do it."

CSS and front-end browser work drives me up the wall.
Star Lite Mk III Laptop Is Now Available with 6 Linux Distributions
Former defense contractor at (Relatively) small company here, this is a reasonable and common sense explanation, especially from what I know from being inside the defense industry. It’s not even far fetched at all. I don’t think this goes to the level or being conspiracy or fringe at all.
Fast, constant and rhythmical heart beats are nothing I worry about. Extrasystoles are pretty much one heart beat out of the normal rhythm (coming from the ventricle in my case), followed by a pause (compensatory pause). Your heart basically stops for one beat, and then resumes. And this pause feels really uncool.
SalesForce ticks enough checkboxes. Competing products may tick the boxes too, but without great marketing that won’t matter, the company that can sell their product will win.

My point was that SalesForce has fairly poor user experience and performance, but does offer the features. It has the additional advantage (for SalesForce) or quick lock-in once the customer commits to it. SalesForce has improved the user experience over time because they have the customer base and revenue to allow that.
It works for 20.04. Sorry if you didn’t get a reply, I’ll look into it. Where did you email us?
yes, that's the scoping issue i mentioned, which can be solved other ways, like with admittedly-not-ideal randomized classes (or 'for' attributes, perhaps with css-style selectors rather than just for id's).
Ha! People are downvoting your comment too. I am also interested in a civil discussion about why people believe they are entitled to the content and service without contributing back. Maybe downvotes are easier than thoughtful replies.
You're absolutely right of course. But it's still a chicken-and-egg problem. YT is frequently the only platform where content creators publish because of network effects.

I guess it's too easy for me to continue using YT for discovery.
With coronavirus antibodies fading fast, vaccine hopes fade, too
On the Effectiveness of Aluminium Foil Helmets: An Empirical Study
Reddit is SO irritating with it's constant push to have you download their app. There's nothing on the site that requires it—Reddit is just listed content of text, video, images, and links. They also limit what you can post from their mobile site which I believe is just further pressure to get you into their unnecessary app.

But my god, they are SO pushy.
When I last worked with PHP, I used PDO because it mostly worked like Perl DBI. I agree that it beat using the old mysql interface in SQL-injection mode, but it was by no means a revelation. The Perl DBI has been around since the 1990s: O'Reilly's Programming the Perl DBI came out in 2000.
Were issues also archived? This badge is specifically an indicator of whether code you committed made it into the vault, not whether you contributed to a project in some other way, or a for other reasons a nice person.

I'm still cynical enough to think that this is mostly a PR move. If society breaks down to the point where we need to open up code vaults, I think massively distributed local archives will be more useful than some remote arctic data center.
The autoloader feature sounds interesting. I've always wondered why there is so much ceremony around importing modules when it seems like the compiler could figure it out in many cases (e.g. when you follow the Go-like style of having module names at the call site).

For example every Java file seems to start with entire screenfuls of imports.

I've never seen that in any other language. Though I'm sure there are a lot of pitfalls, because module systems tend to grow complex over time.
> but surely we can recognize the difference between trained, sworn, gov't-empowered law enforcement professionals and murderers, right?

Those are overlapping sets.
I'm honestly curious as to what mechanism could exist on a mask that could filter air in one direction only (and also why someone would build a surgical mask to do that) - surely you want protection in both directions?
something about just getting the job done, i remember working at a place like that. i think we romanticize it a little bit though. we didn't have any version control, and deploys were literally paste the file on var/www and refresh. onboarding a new engineer, spend a month before they are actually productive.

i'm glad those times happened, they were fun - but i wouldn't want to work like that today.
Code quality and hygiene mean absolutely nothing if you have a large number of academic types who use OpenSSL as the dumping ground for their pet research projects, that are enabled by default, of course.

Also, OpenSSL supports all kinds of ancient esoteric platforms that are essentially unused, yet were kept in the code base for sentimental reasons.

The real metric they should be looking at is the number of features/platforms/LOC removed from the project. Less code = less surface areas for exploits.
You don't have to have the actual DMs. You can make shit up and claim the source is this attack.
While being generally libertarian, I did support the shutdowns because 1. there are many people who have very little choice whether to keep going to work, due to the rent treadmill the government has created 2. some kind of actual change was/is required to snap most people out of just going about their business as usual.

That expensive course of action should have been used to regroup and implement a sensible containment plan. Instead that time was basically wasted, which is need the real tragedy.

> I'm not surprised many americans are against stupidly cheap ways to slow spread to any degree

I've got to ask specifically why would you expect this? I mean I see the general ignorance and deference to expensive centralized solutions. But I would have thought that a pan-partisan shared threat like a pandemic would have put more people on the same page.
I sometimes look at the hiring experiences of other kinds of engineers longingly. Electrical Engineer? Asked to design a circuit. Chemical Engineer? Asked to synthesize a chemical. Mechanical Engineer? Asked to design a car. Software Engineer? 50 million different processes based on the whims of "senior engineer"s with 4 years out of college, mostly trivia questions out of a book that only 1% of software developers actually use in everyday work
This is the traditional Give and Take dilemma. Givers are just as likely to be successful, if not more. This is a good summary, in case you want to skip Adam Grant's book [0]

[0]: https://www.lemonade.com/blog/psychology-givers-takers-match...