skysight-inc/HackerNews huggingface dataset:
I'm not even an armchair doctor, but is there any truth to it being overcomplicated in a way that offers no benefit in this specific situation? My incredibly lay interpretation of the article below is that Gilead purposely designed something much more complicated to synthesize, that ends up being less effective than its predecessor. It reads as if all the over engineering of Remdesivir ended up having no positive result.

https://www.statnews.com/2020/05/14/gilead-should-ditch-remd...

>The company has also developed GS-441524, another pro-drug that, as its name suggests, the body also converts into GS-441524 triphosphate, but in just in three steps. GS-441524 is easier to synthesize than remdesivir, requiring three steps instead of the seven needed for remdesivir.

>Researchers initially thought that remdesivir would be activated more quickly than GS-441524 in human cells infected with the SARS and MERS coronaviruses. Yet data from primary human airway epithelial cells — one of the most clinically relevant cell-based models of the human lung — showed no statistically significant difference in potency between the two compounds. When GS-441524 was used to treat cats with feline infectious peritonitis, a progressive and usually fatal disease caused by a coronavirus, it displayed remarkable safety and therapeutic efficacy, with 96% of cats recovering after treatment.

>Recent research in coronavirus-infected nonhuman primates demonstrated problems with remdesivir that inadvertently showed the antiviral effectiveness of GS-441524. In multiple studies testing remdesivir in coronavirus-infected mice or rhesus macaques, it was rapidly converted to GS-441524 in the bloodstream.

>Take the latest controlled study conducted in rhesus macaques infected with SARS-CoV-2: After remdesivir was administered intravenously, GS-441524 was present in serum samples at concentrations 1,000-fold greater than remdesivir. Upon completion of the study, the researchers found that only GS-441524 — not remdesivir — was detected in the macaques’ lungs, yet they exhibited no signs of respiratory disease, significantly reduced viral loads, and a distinct reduction in damage to lung tissue. Such results reinforce those obtained from a prior study, also in macaques, and data from other species that GS-441524 exhibits strong antiviral activity.

>The first step in the bioactivation of GS-441524 is the rate-limiting step, something that remdesivir was designed to avoid. But that doesn’t matter clinically because of remdesivir’s rapid transformation to GS-441524 in the bloodstream.

There is also a black market for GS-441524, which could be a reason Gilead doesnt want to promote it?

https://www.theatlantic.com/science/archive/2020/05/remdesiv...
My argument is really only about calculating economic damages from piracy, and how it is difficult without information about a pirate's willingess to pay. Even for personal use, if my willingness to pay is $50, but the price is $1000, and I pirate, that's a legitimate claim that piracy caused economic harm to the author. But, importantly, not $1000 of economic harm - just $50. I've deprived the author of the opportunity to price discriminate by putting the book on sale at some point in the future, or bulk discounting, or gathering data about the readership (to e.g. build an email list).

In the case you describe, there is a demonstrated willingness to pay $15, so you have enough information to calculate damages.
Ride-hailing services associated with uptick in traffic deaths
5 years continuous residence is typically the requirement to apply for permanent residence and ultimately citizenship.
Looks like a glitch (as the reddit thread indicates). DDG works fine on BSNL.

Note that r/India is very intolerant of views which are pro-India, and has consequently become an echo chamber for endia folk. I'd take anything coming out of this subred with a bucket of salt.
I think they are in India lol. Even if they were in the US, they can speak any language they damn well please. And I think they might be talking about speaking English anyway, since different regions may have different accents in English as well.
That's the intended use case for Arcan [0] iirc

[0] https://arcan-fe.com/
Seattle police clearing CHOP protest zone
compare yourself to yourself, not others
Usually easier to move around the units to match the standard equations, e.g. voltage is rate of change of magnetic flux.
I believe cancer is only a problem for us overly complex, multicellular organisms. Cancer happens when some of your cells go rogue, so you have to have at least two cells to get cancer.
Well, it's not Wikipedia's fault if people producing intuitive content are not contributing to it. It's not like editors go out of their way to remove nice explanations.
I see the USA as more chaotic than authoritarian.
"... the government to dissolve the people and elect another."
Clinicians more-or-less agree that Remdesivir has some minor beneficial anti-viral impact if given at the earliest moments of infection (like within 12 hours of infection), and some lesser beneficial impact later in cases where the body has trouble getting rid of the virus.

Covid-19 doesn't kill you. Those most sick in their 2nd and 3rd weeks are usually made very sick by their immune system's own inflammatory immune response (cytokine storm).

What this means is that Remdesivir could be very effective for patients that have known exposures and are in high risk categories.

...but, for most clinicians, since it needs to be given intravenously, it's not usually part of the clinical response (for the moment).

This is why the manufacturer (Gilead) is working on an oral delivery system. ...and we should all be supportive of that, because a broad use anti-viral might be very useful for covid-19 as well as other future viral diseases.

Still - what's going to save us from covid-19 is going to be a vaccine (and some degree of herd immunity).
A lot of Amazon retail does close every night. You can put in a request but it won't be fulfilled and shipped until morning. Getting rid of that is a nice idea, but also "instant fulfillment" is not great either without "instant returns." The idea of "instant trading" seems like it can instantly put the system into a bad state with no recourse to fix it.
I’m really curious: what is your experience that you’re referring to?
Isn't it the same thing just obfuscated by two levels of indirection, Patriot Act/Op Choke Point -> VISA/Mastercard -> Social Medias

https://old.reddit.com/r/kotakuinaction2/comments/hi47ci/dic...
I was thinking the other day: if you replace the word "commercial" with "ad", it somehow seems much more ridiculous to be spending $50+ month for a video service, only to still have to sit through countless ads.

It seems obvious, but for some reason, I accepted that TV will have "commercials", but I always associated "ads" with computers. Maybe it's a regional/language thing...IDK.
You're being quite aggressive about your disagreement here. I don't think it's "FUD" to rightfully point out that using inotify on a large directory tree takes extra userspace code that is explicitly called out in the inotifywatch docs as performing poorly enough to worry about race conditions. Not to mention that it requires a limits tweak. This isn't "lazy," it's wishing for the mechanism to be more capable. Would you have this same attitude if the default limit were 1024? 512?
Glide (YC W19) | Senior software engineer | SF, once it's safe | Full-time | https://glideapps.com

At Glide we believe that software development should be dramatically easier. We're starting by making it possible to build mobile apps from spreadsheets, without writing any code. If you want to help us bring software development to the masses, please apply. We don't care which languages or frameworks you're most familiar with - if you're passionate and willing to learn, we have no doubts that you'll be productive in our stack in no time.

https://www.glideapps.com/jobs/senior-software-engineer-san-...

Glide (YC W19) | Senior ops engineer | SF or REMOTE | Full-time | https://glideapps.com

Glide makes it easy and fun for anyone to build apps without writing code, and without maintaining infrastructure. We do that by providing all that infrastructure, and it's growing, and needs help. If our mission motivates you, and you're experienced with maintaining and growing backend infrastructure, monitoring and automating everything, and implementing security, please talk to us!

https://www.glideapps.com/jobs/senior-ops-engineer-remote

Glide (YC W19) | Senior Product Designer | SF, once it's safe | Full-time | https://glideapps.com

We're looking for a Senior Product Designer who has worked on technical products. Glide is building the tool that will create 1 billion new developers by 2030. The design challenge in front of us is turning the complexity of software development into a simple, intuitive, and powerful interface that anyone can use.

https://www.glideapps.com/jobs/senior-product-designer-san-f...
Fought is expressing it mildly; they're outright refusing unless you threaten them with court action.
The limits of trying to speculate about God – Simon Blackburn
Subscriptions mean I purchase far less software. This is an empirical observation - my personal software spending is down something like 80% over the last couple years, and it is due to the friction of subscriptions.

The main thing is I do not like assigning myself future decisions, especially about money, and I don't like ongoing financial obligations.

I'm not saying this is strictly rational; I'm sure there are times I've paid way more for software than a sub for the duration of my use would have been.

But it is true - the friction of the ongoing obligation means software has to cross a much higher bar before I don't go find a different way to solve my problem.

I realize the switch makes software companies more stable, etc. All true, and it has zero to do to my decision making.
Supporting HK in gaining independence wouldn't have been an act of Colonialism. It would have been enabling self determination of a population. Colonialism is "the policy or practice of acquiring full or partial political control over another country, occupying it with settlers, and exploiting it economically." Giving the HK people independence is literally the opposite of colonialism.

In contrast, the new law by by the CPC is an act of colonialism by definition as it is the CPC overriding 1 country, 2 systems and asserting political control over HK.

The British providing a path to independence could have been very similar to Belize (with CPC being equivalent to Guatemala in this case).

The British left a battalion of troops in Belize, the British Forces Belize, in order to act as a deterrent to a Guatemalan invasion.[1][2]

While China is obviously much more powerful than Guatemala, they still wouldn't have been able to invade given that it would have caused a nuclear war. Also, at that point China was much weaker economically so an economic war would have severely hurt their economic growth, undermining the key source of their power over the past 20 years.

[1] https://en.wikipedia.org/wiki/Belizean%E2%80%93Guatemalan_te...
[2] https://en.wikipedia.org/wiki/British_Army_Training_and_Supp...
No your reasoning is way off. I map to ctrl rather than escape because I want to make use of the Insert and Ex mode ctrl shortcuts.

For example, if I want to insert a register into the ex mode command line I use ctr-r <register>.

Or if I want to pop out of insert mode for a single command I use ctr-o.

E.g. inserting opening and closing tags when a suitable plugin isn't present. Insert the opening and closing tag, jump back to command mode with ctrl-o, move backwards and you're ready to insert more text.
We see that the convenience of centralized social media is more valuable than the autonomy of federated social media. This is because the centralized social media is easily accessible, practically free and tolerably open regarding opposing viewpoints.

Solve for the equilibrium. We would expect federated social media to increase in popularity when the convenience of centralized social media is jeopardized. I believe in Russia, where people don't feel safe voicing their opinions publicly on centralized social media, ad hoc social networks have appeared on safe chat platforms like Telegram to take their place.
> This level of brain drain, as in the other mass migration events away from HK, could trigger the government to loosen their grip.

I've heard that HK is no longer as important to China as it was 20 years ago. HK's contribution to China's GDP has declined in relative terms as the rest of China has developed. With regards to the brain drain I get the impression that there are plenty of people from the mainland that could fill the gap.
Scaling Pandas: Comparing Dask, Ray, Modin Vaex, and Rapids
HN Said my post was too long, so I made a small challenge:

+[----->+++<]>+.++++++++++++..----.+++.+[-->+<]>.-----------..[--->+<]>++.++.++++++++++.+.[++>---<]>.+[--->+<]>++.++.+++++++++++.------------.[--->+<]>---.+[->+++<]>.[-->+<]>---.--[--->+<]>-.++++++++++++.--.+++[->+++++<]>-.+[----->+<]>-.-------------.-.-[++>-----<]>+.++++.++[->+++<]>.++++.+++++++++.---.+[->+++++<]>-.++++++.--.--[->++<]>-.+[-->+<]>++++++.-----.-[->++<]>.[-->+<]>+++.--.+++++.-----[->++<]>.[-->+<]>-.+[--->+<]>.[->+++<]>.+..+++++..---.---.[->++<]>-.+[-->+<]>+++++.-----[->++<]>-.-[------>+<]>--.-[--->+<]>----.++.----..[-->+<]>++++.----[->++<]>-.++..+[-->+<]>+++.

( clueless recruiter filter ;-) )
The Tricky Math of Covid-19 Herd Immunity
Yep, this is called a "manual action" by Google, and they'll often tell you exactly what you're doing that they find offensive. Usually this involves buying spammy backlinks. You can resolve the issue and ask them to re-evaluate your site by submitting a Reconsideration request.

https://support.google.com/webmasters/answer/9044175?hl=en
You have to watch Comcast, though. Does the quoted rate include their local station rebroadcast fee? Their "sports fee"? These two together were something like $14/month -- and not disclosed in the price of any package -- when I finally dropped their scammy ass about 16 months ago. PLUS any boxes you may or may not have to use.
Or just in your case fail to understand App Store rules and UX.
The statues are not arbitrary and many of them have been objected to for years.

Similarly, US police have been routinely murdering people for years. What social media has done is allow the creation of a "headless" protest movement that can outrun attempts to take it down.

In both cases, some people have leapt in and gone too far because they enjoy the chaos, but don't let that obscure the real issues.

No, the problem of social media is reactionary movements arising against entirely fake problems, like "pizzagate".
The CPP would like to have a word with you for referring to Taiwan as a “different country”
I'm confused. Are you saying he had an ulterior motive? Tamiflu is effective when given early. The stockpiles (which I doubt amounted to the billions) were for the general US population in case of a super-flu. ...so it was a good idea.
Repl.it (YC W18) | Frontend, fullstack, mobile, backend, designers | SF | https://repl.it/jobs

Repl.it is the first massively open collaborative computing platform where anyone, even without even needing an account, can hop on and in seconds start coding, building, and hosting apps and websites.

Apply if you like working on challenging problems, because running a service like this is hard to operate, scale, and secure. Also, supporting the number of languages we do (https://repl.it/languages) is a hard tooling problem -- we have to build generic protocols for all IDE actions like executing, debugging, authoring, running tests, writing files, etc. Finally, it's an incredibly challenging frontend/design problem to build a fast collaborative in-browser IDE that's both powerful and simple.

It's a great time to be joining us, we're still 12 full-time people, we reach millions of coders a month, and we're backed by YC and a16z.
I've been a Freescale/NXP customer for decades and I like their stuff. Their documentation is comprehensive, their technical notes and errata are free to read. They're not perfect but they work at it. Their Github presence is decent. iMX is a good line for Linux, LPC for microcontrollers but the new iMXRT parts are looking great for FreeRTOS.

I don't work as much with TI but I've used Panda in the past for OMAP4 and some personal work with Beagle/AM335x and it's solid stuff. I'd like to think Beagle's community is as good as RPi's, just a little more low-key (and the chipmaker participates as well)
Pachyderm (YC W15) -- San Francisco -- SF or remote (within North America) -- https://jobs.lever.co/pachyderm/
Positions:

* Core distributed systems/infrastructure engineer (Golang)- You'll be solving hard algorithmic and distributed systems problems every day and building a first-of-its-kind, containerized, data infrastructure platform.

* Front-end Engineer (Javascript) - Your work will be focused on developing the UI, perfecting the user experience, and pioneering new products such as a hosted version of Pachyderm's data solution.

* DevOps -- Pachyderm is hiring a deployment and devops expert to own and lead our infrastructure, deployment, and testing processes. Experience with Kubernetes, CI/CD systems, testing infra, and running large-scale, data-heavy applications is important.

* Solutions Engineer/Architect -- Work with Pachyderm's OSS and Enterprise customers to ensure their success. This is a customer facing role that bridges support, product, customer success, and engineering.

About Pachyderm:

Love Docker, Golang, Kubernetes and distributed systems?

Pachyderm is an enterprise data science platform that offers Git-like version control semantics for massive data sets and end-to-end data lineage tracking and auditing. Teams that find themselves struggling to maintain a growing mess of advance data science tasks such as machine learning or bioinformatics/genomics research use Pachyderm to greatly simplify their system and reduce development time. They rely on Pachyderm to do the heavy lifting so they can focus on the business logic in their data pipelines.

Pachyderm raised our Series A led by Benchmark (https://pachyderm.io/2018/11/15/Series-A.html), so you'd be getting in right at the ground floor and have an enormous impact on the success and direction of the company as well as building the rest of the engineering team.

Check us out at:

pachyderm.com

http://github.com/pachyderm/pachyderm
Lots of exchanges have rate limits and messaging fees. And even if they don't, if you cause problems they'll shut you off.
All of that is of course theoretically possible with LSP or other vim extensions. It's just that nobody did it.

Another thing is the level of integration. There are many tools which offer static analysis, duplicate detection etc. But it's completely different level of usability when you see this info immediately as you type.
Ask HN: Does your company Zoom or nah?
Why or why not?

For my current job, the answer is 'nah'. I think the reason is: because we are technologically incapable of doing it, even if we wanted to do it.

(Don't shoot the messenger.)

We do audio/screenshare-only meetings -- i.e. we do not use Zoom or other software to put our faces/bodies/apts/houses/dogs/children/significant-others/furniture/books/social-class/personal-lives on camera.

I have decided I really like this, and this is the best way to work remotely.

Sometimes we do audio-only meetings without the screensharing, and vice-versa.

There now seems to be some counter-momentum to the Zoom/video-is-better (because non-verbal communication is everything*) narrative, but I'm curious if my company is unique in this no-Zoom regard.

I don't have a "Zoom Shirt".

I consider the ability to work without video on me to be a major plus of my current work situation. I would even like to search for a new job with this as one of my primary criteria -- pretty close to a prerequisite.
$200 isn't a big deal for something you really want, but at the margin, on projects that you don't even know you're going to bother finishing, it's the difference between being able to justify taking a punt on it and not.

That's why the Raspberry Pi is so popular.

I agree with everything you said about using cheap microcontrollers to experiment with basic electronics projects.
Location: US

Remote: yes

Willing to relocate: No

Technologies/Tools: React, Vanilla JS, HTML/CSS, Adobe Illustrator/Photoshop, Asana/Trello, Slack, Excel

Resume: https://bit.ly/3ilaWWo (slanted toward jr dev role, but open to discussing any opportunities)

email: melissapearlmorgan@gmail.com

Hi there! I'm Melissa, and I'm looking for an entry-level remote position at a tech or tech-adjacent company. I’ve lately taught myself React and have built a few personal projects: cloudmaker.site and mightymorse.com. I have an eclectic background including sales, UI/UX design, web development, and a bit of product design and copy writing. I care deeply about both products and the people who need them.

If your team needs a positive person with excellent communication skills who can get things done, let’s have a zoom call! I’m confident that I can bring a ton of value to your team.

57-second video intro: https://www.loom.com/share/0609ad92c39f4fec92e9dd243b106fbd
Not the original poster, but Windows allows you to get all changes in an NTFS volume, effectively allowing you to monitor notifications to an unlimited amount of files and directories (didn't remember what the feature was called, a quick googling led me to https://docs.microsoft.com/en-us/windows/win32/fileio/change... ).

This allows software like Voidtool's Everything to index the entire filesystem and update that index in real time. Using inotify for that is not possible since you'd have to recursively register for hunderds of thousands of directories, which far exceeds the limit of allowed registerations (and either way, would be quite wasteful to hold 100,000 registration handles). As a result, the Linux equivalent to Everything is unable to find recently created files, erronously finds deleted files and has outdated metadata fo recently changed files. Alternatively, you can attempt to reindex right before searching (e.g. rerun updatedb if you are using locate), but then your searches are much slower and the benefit of indexing for a quick search is reduced significantly.

A nicer API would allow to use one registration handle to get notifications for an entire directory tree or at least have a seprate API for an entire filesystem (like the NTFS option mentioned above).

At least, that was the conclusion I came to when I last researched the topic. If you know of a supported way of doing this on Linux I'd really love to know! It will allow me to finally make the program I wanted to make!
A Descriptive Guide on DNS