skysight-inc/HackerNews huggingface dataset:
Typical shoddy journalism. Bandies numbers about: '150.000', 'up to 3 million' , when talking about the numbers likely to qualify to come to UK but never actually tells us what the population of Hong Kong is in the first place. So is this everyone?... 50% of the population?... 25%?.. 10%?...
Technically true, but completely misrepresents the issue.

Discovering (100s of)compounds in a lab (which is what the public funds pay for) is the easy and much cheaper part.

Testing it in humans and modifying it for that purpose is hard, expensive, and time consuming. Pretending like these drug companies do nothing and just take all the benefit from public research is incorrect.
Show HN: The Slice – Newsletter for founders, by founders
From the article it's 'just' a 1x PCI-E 2.0 lane (theoretical 5Gbps throughput). This is all the VL805 expects so all that's broken out to it's pads and 'easily' accessible.
FYI, the guidelines state:

> Please don't comment on whether someone read an article. "Did you even read the article? It mentions that" can be shortened to "The article mentions that."
I think psycohistory would also be a requirement!
This article lists some key provisions from the Chinese Communist Party's security law:

https://www.bbc.com/news/world-asia-china-52765838
Definitely read the sequel Judas Unchained. Those books are probably my favourite novels.

For more Peter F Hamilton optimistic future of humanity, see the Night's Dawn trilogy.
What Christian beliefs do you think are problematic?

I'm an atheist myself but I don't see many things in Christianity that are particularly bad (...I just don't believe in the supernatural).
Your framing of Ely's justification for the 1st Amendment did not make it clear that you wouldn't support banning speech you find particularly egregious. I'm happy to have been wrong.
It is 1x, obviously. But I highly doubt that the PCIe bus is going to be the bottleneck here ;-)

I guess it would be possible to design an ATX size motherboard with a RPi4 compute module slot (once CM4 becomes available).
The PCIe bus would allow all sorts of peripherals. Don't expect any performance though.
1) vim is easier on your hands if you're on a high-latency connection (i.e. usable in a terminal) and/or get tired of chording (i.e. having to press Ctrl along with random keys).

2) I've found vim's plugin systems (Pathogen, Vundle, vim-plug) vastly more intuitive than Emacs' version with package-install and activating one of several repositories (Milk, ELPA, MELPA, whatever) - you install the same plugin regardless of whether you're using Vundle or vim-plug

3) vim and its packages are vastly easier to configure - this is subjective and may be much improved in Doom Emacs/Spacemacs, but in general vim packages have a bunch of global variables that you can set to a number or a string whereas most emacs packages need you to define elisp functions and/or nontrivial data structures, with no sane defaults to fall back on if you want things just to work
More validation of the dark forest theory?
US has as well to some extent [1]. I hope the entire Anglosphere follows suit (CAN/AUS/NZ).

[1]https://www.wsj.com/articles/hong-kong-police-make-first-sec...
A much easier way to troubleshoot distributed databases
Based on your link, various American government agencies contributed $70MM to the R&D of remdesivir. While I can't find the total R&D cost for this particular drug, the average R&D cost for bringing a new drug to market is about $1BN [1]. Draw your own conclusions.

[1] https://www.biopharmadive.com/news/new-drug-cost-research-de...
https://remoteworkjobs.io
Yep:

- External drive with a bootable backup (Carbon Copy Cloner)

- Network drive with automagical Time Machine backups

- Offsite versioned backups (for example Backblaze)

"Pride goes before destruction, and a haughty spirit before a fall", but I'd be surprised if I ever will lose a file like this.
https://twitter.com/garrytan/status/1074392721912000513
See what I was saying in the OP about the average JS developer :)

It's not even their fault, it's all they know from those online courses or boot camps.
awesome idea. makes no sense that incarcerated people & their families are paying such steep prices while the rest of us are using hangouts, zoom, facebook, whatsapp, etc for free
> Also remote jobs will usually pay less because the supply is much higher, you compete with 100x more devs than the local devs, some from poorer countries where 20/h is a good rate.

Is there any data for this?

In my limited experience this was not the case but I've never really looked for a remote job
I have actually been a foster parent, and have had kids come to my house at 11pm, that you can smell from 7 feet away, covered in lice, with a single backpack with all their possesions. One kid called 911 because mom and dad wouldn't wake up (heroin). Some suffering from Sex Abuse, some literally starving, etc. Yes, Foster Care has its problems (and part of why I don't do it anymore) but there ARE legitimate needs in the communities. I would love to know what you think it should be replaced with?
Here is one: when you switched on a C64, the booting(startup) took probably less than 3 seconds. Booting a notebook these days takes longer (luckily it is not as bad as when we didnt have SSDs).

But generally I do not think the premise is correct. Loading a game from a datasette took easily 15 minutes (later there was acceleration only a few minutes)
> I fully agree with you. I have no idea why you are down-voted so heavily.

Maybe because they claimed it's easy to solve when the solution they proposed in fact has a whole lot of undesirable consequences that are obvious to anyone more familiar with how markets work.
It's 1 lane, but a 16x connector to allow plugging in any device. PCIe devices can be downgraded into a lower number of lanes. Many motherboard 16x connectors aren't even a full 16x.
Because the discussion above was about email. A browser is not a mail client (as in MUA). Unless a browser implements the RFCs regarding email, it's only a web browser.

>How about email apps such as Gmail or Yahoo mail?

So the answer is: It doesn't matter as those are not email apps. They are email frontends for a service that implements mail. If people think differently - it's their wording, but still a wrong one.
The experience of the 80s was slowness, things were so slow that it's unimaginable now. So unimaginable that we don’t remember the feeling anymore.

The experience was so slow, that you can play another game while loading [1]. Namco even patented "playing games during load” by 1987 [2].

As an example, I have fond memories of my C64 tape loading Hunchback [3] ... while watching "V". A single tape can take one hour if it fails in the middle and you need retries. All those waiting times were order of magnitude of what a common toddler will expect today. We were so relieved when the fast loaders appears [4] or when a 1541 arrived home [5]. And then we were so frustrated when the 1541 was only 300bytes/s instead of the 300bits/s of the Datasette.

The scenario in Xenix or PC-DOS loading from 8" floppies was similar.

I'm not arguing that now are better times, I’m arguing that in the 80s we have the best for the time, and those were good times to remember.

[1] Mini Games: https://en.wikipedia.org/wiki/Invade-a-Load

[2] Nanco patent: https://patents.google.com/patent/US5718632A/en

[3] https://en.wikipedia.org/wiki/Hunchback_(video_game)

[4] https://en.wikipedia.org/wiki/Fast_loader

[5] https://en.wikipedia.org/wiki/Commodore_1541
A simple way to include performance in the development activities without ending ib premature optimization territory is to introduce timing budgets.

Decide for each operation how long it us allowed to take. E.g. pushing this button reacts in 100ms. Make your tests record these times. Optimize when it becomes clear you're not going to make it.

There was an intervieuw with the Intel engineer that got the linux laptops booting in 10s. They budgetted, x seconds for kernel, y seconds for X11, etc. .
Again, not 1983, but I was using a DOS (iirc we didn't buy the Windows version because it was too slow) mapping tool to create routes for trucks around 1990/91.

It was slow, awkward, and needed a few days' training to get up to speed with. Redrawing a map on the screen took a couple of seconds. Scrolling around to find stuff wasn't really possible. But give it a postcode and it knew where everything was. And give it a list of 10 postcodes and it would spit out the best route a few minutes later.

Google's UX for everything except search is utter shite. I don't know what they think they're doing. Anyone here from Google who can explain why their UX is so crap?
I never said they did nothing. I'm pointing out that they aren't the John Galt story that people are lead to believe when people mention "recouping cost". And like any other shareholder, shouldn't we see something of a benefit for putting up our own capital?
It's so weird that people here usually want to regulate social media, but when some other government that doesn't share your worldview does it, it's all of a sudden oppressive.

You say the wrong thing online in the UK or Germany, the police come knocking. Everyone always thinks their reason for censorship is exceptional because their beliefs are the one-true virtuous beliefs in the universe.
We replaced an AS/400 (well, iSeries) accounting/inventory system with the hot new web-based ERP from DATABASE_CORP.

People had been using this system for over 20 years. Muscle memory from hitting Tab, Tab, F2, enter...that pulls up the inventory detail. F5, 3, 6, Tab, that brings up the wholesale price.

Now, with the 'better' system, people have to move the mouse up to Lists, Items, wait for the Item page to load, then choose the item the want, wait for that to load, then click on the Inventory or Pricing tab, wait for that to load. They can save a few steps by typing 'item: 25630' in the search bar. But of course it loads about 5x slower.

You could also hit PgUp/PgDn to cycle through items. Now you have to click the little arrows at the top of the page, and the view resets each time, so if you were on the Pricing tab, you have to click on that again. The old system left you where you were.

Sure, the new system has all kinds of advantages in other places, but to most of the internal users, you just ruined their world and they hate the unfamiliar, slower system that costs millions of dollars.
Or Vernor Vinge's A Deepness in The Sky, which is also excellent.
A somewhat related idea: the discovery that light is an electromagnetic wave falls right out of Maxwell's equations in a vacuum. Simply rearranging terms yields two wave equations in 3D - one for the electric field, and one for magnetic. The term in both wave equations representing the speed of propagation (i.e. the speed of light) is a constant. It depends only on the physical properties of the vacuum, which never change as far as we know. That means an observer traveling at any constant velocity with respect to light will always measure the speed of light to be the same. Maxwell died in 1879 at the age of 48. It is not only plausible but likely that he would have come up with special relativity had he lived a bit longer, and also likely that it would have been years before Einstein published his 1905 paper on the subject.

So in addition to the Stigler's law [1] situation with Heaviside, the formulation of special relativity may have been more or less inevitable after all of Maxwell's laws were put in the same room together. Not that Einstein wasn't a once-in-a-generation talent, but the reality of how progress is made in science is often glossed over in favor of assigning glory to particular individuals.

Even Maxwell's laws taken individually are named after different people, but together they all belong to Maxwell. I get that this practice is intended to be a convenient way to put a label on an abstract concept rather than a way to write history, but I still think it has an effect on how we think and talk about the history of science.

https://en.wikipedia.org/wiki/Stigler%27s_law_of_eponymy
I remember waiting at least 8 minutes going from boot to a usable desktop on windows 95. Opening up IE completely froze the computer for 2-3 minutes while it churned away. Minimizing mech warrior would take 45 seconds as I literally watched the desktop be slowly repainted pixel by pixel. Installing 400mb daggerfall took all of a half hour. Applying an image filter in paint shop pro took 15 seconds at a time... the idea that computers are perceptually slower today than in the 80s is just totally false. I get the sense that people parroting this kind of nonsense are simply invested in an ideological narrative that means to disparage the contemporary programmer as lazy or uninformed because they grew up at a time when you didn't have to manually manage menory... as if that was some kind of computing golden age.
Seems reasonable. I do share this concern:

>Breyer argued that what's really at stake in this case is the ability to register domains that are similar but not identical to booking.com. Thanks to today's ruling, booking.com could "threaten trademark lawsuits against competitors using domains such as bookings.com, eBooking.com, booker.com, or bookit.com," Breyer wrote.

Without even buying similar domains, a company can prevent them from being used via trademark law.
I know it's a dead meme by now but "Ok boomer" works pretty well with my Google Assistant.
When this happens, will we still be able to sideload into the Go? Haven't found a solid answer for this yet.
Yes absolutely, the variance of pricing across different custom synthesis providers can be surprising. This we think though is actually an opportunity to serve our end users (drug hunters) better. Generally the cost of synthesis is a function of raw material costs and the labor time (translates to number of synthetic steps and risk of each step). All these parameters are datapoints we have access to or can model through ML. As such we've found that the ability to search large chemical databases is a huge saving when many clients may often just default to use a single CRO provider who may not be the best provider for their synthesis request. We are aiming to build a good network of reliable CRO providers to address the shortcoming and work with them to improve algorithms to optimize for reaction conditions etc.

Regarding pricing model this is something we are still working on. And yes you've hit the nail on the head -- We could charge the drug hunter (SaaS or IP) or we could charge the CROs that we send the custom synthesis to. Love to hear your thoughts here.
I do not see how contemporary Russia is "desperate in acquiring more territory".

My
interpretation is as following -- please correct me if I'm wrong. Note: I am not endorsing (nor criticising) Russian policies here, just trying to understand and learn. In order to learn, I try and give as clearcut an explanation as possible of my current understanding, so as to make it as easy as possible for others with more expertise to point to where I am wrong (if indeed I am wrong).
My take is this: contemporary Russian policy is a variation on "spheres of influence"
[1], and Russia treats its neighbours as being in its "sphere of
influence", and does not accept them becoming part of NATO. I think
the implicit deal with "sphere of influence" neighbours is: as long as you don't
join NATO, you can do whatever you like but as soon as you try to
join NATO we will stop this, including with force. Currently, Russia has borders with the following NATO countries:
Norway,
Estonia and
Latvia. The latter two joined NATO in 2004, when Russia felt too weak to do anything about it, especially since they are not land-locked, so could be easily be defended by western Navies.

A clear example of this was the Russian-Georgian War in 2008. Russia
withdrew after a couple of days (but left some "Frozen Conflicts" [2]
in place that it can 'turn on' at will, as a power-lever: South
Ossetia and Abkhazia). Who would have defended Georgia if Russia had decided to stay, Armenia, Azerbaijan, Turkey? Probably not.
Likewise, Russia could easily invade an keep the 'stans. Take land-locked
Kazakhstan: huge, rich in resources, nearly empty, and, thanks to Stalin's policy of
mixing ethnic groups, about 1/4 of the population is ethic Russian anyway (in 1989 it was
nearly 40%). Who would defend Kazakhstan? Mongolia, Uzbekistan , Tajikistan, Kyrgyzstan?
Probably not.
Ukraine is an interesting special case, and the annexation of Crimea
can be interpreted in this way: Ukraine came too close to NATO,
and Crimea is important for the ability of the Russian navy to
project power in the Mediterranean Sea. Crimea is > 2/3 Russian from
the POV of ethnic groups and Russia has a higher standard of living than Ukraine, so the majority of the Crimean population would probably have been ok with the policy anyway.

[1] https://en.wikipedia.org/wiki/Sphere_of_influence

[2] https://en.wikipedia.org/wiki/Frozen_conflict
How do you imagine millions of people will die again?

I plan to disagree, but first I need to know what the hell you're trying to say.
Unfortunately that doesn't have to mean anything. If the courts are biased it is possible they are only convicting if the evidence is so strong they dare not. Or maybe some courts are honestly decided and others are corrupt...

I'm not in India so I have no idea what the truth is. I do know corruption is a problem there and corruption is a hard problem to solve.
> Cheap to write beats user experience I guess.

I think it'd be more accurate to say value to the user beats the cost to write the software, which then beats user experience.

Something can offer a lot of value and use but still be a pain to use.
These are some very good suggestions. I think they should take note on how the Kubernetes project operates, with the various interest groups, Slack channels, meeting notes + their recordings on Youtube. I think those channels catch a large part of the history of the development. I'm not sure if Linux uses anything beyond mailing lists.....
Most of this is a rant against Google Maps UI. I'd like to do a shout out to Bing Maps, which does keep a list items as you look them up. You can swap between them, and see all of them on the map. Also, I find the Windows 10 app (called Maps) very smooth.
> Is mentioning white British privilege over low-caste Indians now a flagging offense?

Flat-out, deadly, insults are. It was delivered as an insult.

> Don't take this the wrong way this is your white privilege showing

I didn't "take it the wrong way." I took it exactly as it was intended.

What's ironic, is that the insult was delivered without the person even taking a few minutes to find out a bit more about me. I don't hide anything. It's all there, for you to examine.

I understand that this is an emotional issue, which was why I carefully kept all of my responses to my own experience, and never made a value judgement.

I'd suggest that you read through all my comments, and point out my insults. If I have inadvertently done so, then I sincerely apologize, and will make any amends possible.

I am not Indian, and won't even pretend to understand what Indians of lower caste go through, but I do have some experience in the British system.
I would love it if subscription services would give me a heads up a day or two before the trial period ends, with a link to cancel.
So apples to oranges.

Adding features will almost inevitably make software slower. Sometimes the difference is smaller, sometimes larger.
Pandemic aside, the US government shouldn’t get a better deal than any other investor. If you invest “tens of millions” into drugs that will cost “billions” to bring to market, you don’t get to get the drug for free. Imagine a Silicon Valley investor proposing those terms: we’ll invest $1 million in your startup for 75% of the equity. But that’s exactly what people are proposing when they say a few tens of millions of government funding should buy free access to patented technology that takes hundreds of millions to bring to market.
That seems like a huge mistake to me. As it's been said many times, "Safety regulations are written in blood." At this point we probably know more about the flaws in the MAX than almost any other aircraft. And it's not like the plane was fundamentally unsound at a design level, but that bean counting, shortcuts and a failing culture made it unsound.

I mean, I haven't heard anyone of authority say the flaws with the Max aren't fixable. If the Max "never flies again", it will just be because it's rebranded, not because it's a fundamentally different aircraft.
Very good stuff to read. I'm sure many like me came to the same conclusion on a [shall we say] more emotional level where a few good examples are enough to tip the scale. That book really demolish the monopoly rights from a functional perspective. An argument much more convincing for those who still think patents have merit.

Prince applauded Napster and said people could finally go back to making music for the sake of making music.

I personally don't consider any entertainment important enough to play a role in the design of society. As long as people are working themselves to death merely to sustain themselves they shouldn't be made to pay for your entertainment in any way.

That it also doesn't make any technical sense never truly occurred to me.
My guess is Russia or China. Then the US will be fomented into supporting this terrible plane as a patriotic duty. People will start taking "Freedom Flights" to prove to those bad people "over there" that America is #1!
Almost like the DOM Web API isn't useful for its intended purpose anymore and should be replaced or built upon to avoid all this abstraction churn. Why is simplicity the enemy of the Web APIs? Why is everything useful left to user-defined dependencies? Are the spec creators even checking to see what their code looks like when people have to cobble it together to create something useful? I suspect they are NOT.
My partner and I speak Chinese and English at home and I cannot tell you how many times random Chinese phrases trigger my Homepod (set to listen for English).
I don't miss the 2 minutes to boot up or 10 seconds to start Word and 60 seconds to start Adobe products.
> Hm. I remember Windows 2.1 would composite the screen image right on the tube. You could watch it paint the components in bursts

I wish there were more things like that. I would rather see computers work than see some fancy animation that is there only to look pretty, but ultimately ends up wasting time.
Well, let's take an example :
"It also avoids situations where you can be fined for insulting the president by holding up a sign that says "get lost, you prat" (France)."

The police fined the guy, which doesn't mean that the french people supported the police on this (they didn't), and that the law supported the police on this (it didn't).

So either police actions are a good scope to evaluate the importance of free speech, or either they aren't, but it shouldn't be only when it's convenient.
> I have never had a problem getting partial to full refunds on Ali Express

I've never really had an issue with online refunds anywhere. That doesn't mean Amazon's experience isn't superior. Amazon's policy of refund first, ask questions later (for stuff in the <£15 category at least) means that I don't really consider the other options.

If I have a choice between buying a USB to DC5v adapter from amazon for £3.99, with next day delivery, and I know that if it's not the right cable I'll get an instant refund, or from aliexpress where it's £1.99 [0] but I have to wait 30-50 days for it to arrive, plus 3 weeks for a refund if it doesn't work, I'm just going to buy it on amazon. I don't care if I don't come out ahead!

[0] https://www.aliexpress.com/item/33051428867.html?spm=a2g0o.p...