skysight-inc/HackerNews huggingface dataset:
In the end, all non-human testing of potential treatments are meant to be fail-fast/fail-cheap. In terms of fail-fast, the timeline for seeing "lifetime" effects of a drug is far shorter in a rodent than in a human. In terms of fail-cheap, the ethical and monetary cost of a rodent suffering or dying due to unwanted effects of a drug candidate is judged to be lower than similar suffering in a human.

I do agree that lab animals aren't a resource in themselves – they're just the currently "next best" model to test in before trying a drug out in humans. In fact, mice are actually quite expensive in terms of time and money – custom-genotype mice can cost hundreds of dollars each, and that's just the up-front purchase price. The overhead of maintaining a mouse line is also quite high, with a huge loss incurred for accidental death or euthanization before they've been used as a model. When many research facilities were first shut down due to COVID lockdown this year, I heard that many labs at my university had to euthanize all their mice as they wouldn't be able to care for them. This represents a loss of months of research time and possibly thousands to tens of thousands of research dollars.

Another thing to consider is that many drug candidates that make it to the animal testing stage don't succeed with safety and/or efficacy testing. According to the FDA, 92% of pre-clinical animal tests actually fail to predict drug effectiveness in humans. This highlights a pressing need for other fail-fast/fail-cheap methods that should precede animal testing, like cell culture methods that could be used as a pre-animal screen.
It didn't survive the crash though, which is what you'd need to prevent a radioactive materials release.
247wallst
Any meaningful connection is going to be too expensive for someone like GP, I am afraid.

This is a false generalization. You don't have to choose a big-name New York PR agency. There are thousands of other shops that are quite affordable. Some are just one or two people, and can be surprisingly effective if you pick the right one.
Exactly.

MBA students are going to be looking for specific indicators and terminology (OKRs, KPI dashboards, etc) and things like comp plans. That's not because they are stupid or evil, it's just their world. They aren't trained to understand performance management in an environment where collective bargaining gives employees due process rights, for example. Conversely, public sector leaders are going to struggle with Sarbanes-Oxley compliance or financial decisions that incorporate tax optimization.

Your state/local government isn't going to provide meaningful incentive compensation, for the simple reason that it doesn't work in most cases and taxpayers won't tolerate paying rewards to people for doing their job.

You also need to evaluate the effectiveness of governance differently, because management within an organization is not empowered in the same way. If Congress or a state legislature decrees that you must do X in Y way, you need to do Y, even if it doesn't make sense or is inefficient. Usually in a corporation business management is expected to own their P&L on a broader scope and optimize. Public sector managers can only optimize in the (more limited) scope they control, and only with the consent of the elected/appointed official or board.
To be fair, I wouldn't host my website on my world-class supercomputer either, if I had one...
This. I never understood the "every idiot can do it gui server" thing, just because everybody can doesn't mean everybody should.

Have we already forgotten how Microsoft Exchange singlehandedly launched an entire spam industry?
Coffee/caffiene is only really useful to me when I have to do something I hate.

Otherwise I'm more productive without the crash.
If you cut a 40k check annually to every homeless person and handed it to them on Jan 1st, I would bet the majority would be back on the streets by April, most of them earlier.
We're living in an age in which AWS dwarfs all the machines on the TOP500 taken together. The TOP500 is a vestige of the cold war that needs to be retired. Similarly to how the US and the USSR used to compare their numbers of nuclear warheads, it is comparing a reserve of capacity that is probably going to be retired having brought marginal benefits at best, all in order to goad taxpayers into a futile competition.
No a cheap Porsche is a much better driver than an expensive Corvette. Porsche is about the driving experience as much as speed.
The World in 2036: Nassim Taleb looks at what will break, and what won't (2010)
I like my coffee black-no-sugar, but sometimes my stomach doesn't like it as much as I do. I find that a dollop of cream prevents any stomach issues. I suppose by neutralizing the acids int eh coffee, but that's just a guess. Of course, this may not work for you if you're lactose intolerant.
> Is "glycaemic control" a general benefit, or is that only good for people with diabetes (and other conditions?)?

Great question. My guess would that it would be correlated, at least. If you check this out, please share back what you find.
I usually like to answer questions, but for me it feels like the quality of the questions and the community has gone down overall. Most of the questions asked are from new users and are low effort, duplicated, one google search away from hundreds of answers, all of them at once. I feel like it turned into a social network, where 90% of the content generated is garbage or just duplicated content. Why I don't like this is that it encourages bad habbits for new programmers, where instead of trying to figure out how to solve a basic issue, they just ask on SO and expect a complete answer that includes valid code, so they don't actually learn anything from asking that question, they just want someone else to do their "homework".
The G5 and Core Duo were not that far apart, performance-wise. Certainly nothing like 68k vs PPC. Rosetta worked because most software isn’t CPU-bound; software that is got native versions very quickly.
Ah, thanks! I presume that is done for compactness, because I otherwise see no reason to pack an application type in with the built-in types.

FlexBuffers could support a similar scheme if we wanted to, though putting custom data in the format is already easy enough using the "blob" type, which is arbitrary bytes much like the MessagePack feature.
Because it's beyond the scope of a comment box on a web forum.

It's like asking someone on HN "Tell me how to hire a good person." I can't hand-hold someone through the internet.
That talk is not about the benefits of dynamically typed languages over statically typed languages. Do you have a specific point in mind?
Question: Are you a manager spending your department's education budget or are you the victim it's being spent on?
Are you literally not looking around at all these days? Your filter bubble must be very, very small and selective indeed to somehow have missed Cancel Culture.
Wow, that looks like a killer feature for .Net

I will definitely steal some ideas from Coyote to drive Nim formally verification story of concurrent code forward.

On the Rust side, i feel like Loom has a lot of potential https://github.com/tokio-rs/loom and I'm keeping tabs on them.
Then I'm very confused by what you originally wrote:

> Large parts of Africa and almost all of Latin America are more highly educated now than 1970s Europe and poorer than it.

Brazil's economic growth has been between 5% and 10% since the 1970s. That's pretty respectable. So how can you claim which is the causation?

> I said that education was a consequence of economic growth, not vice versa.

> The most obvious example of economic growth not being associated with education is post Deng Xiaoping China. The huge majority had primary school education at best and the economy just kept growing and growing.

From your own source, China also has a greater proportion of the populace in third level education than France did in 1970. In fact, the chart for China looks very similar to Brazil. And with both countries "the economy just kept growing and growing."

> If you do a regression of changes in education over time versus changes in economic growth there is no trend.

Source? Where can we find that analysis?

> That Brazil is not competing with 1970s France is irrelevant to my claim. Education is a consequence rather than a cause of growth.

You don't have to look at relative education levels to understand if a competitive advantage in education leads to growth? It would be naive to claim any change in education will result in economic growth. So hopefully what we are talking about here is changes in education that lead to one country being ahead in education in some qualitative measures. At which point you would be able to understand whether or not being ahead of another country in education results in growth.
Elastic’s Optimism in the Cloud: $100M+ ARR, growing 100%+ YoY
Conflicting reports if ya search online.

If you were to concentrate and inhale the smoke from roasting beans, that would most certainly have deleterious health effects.

It stands to reason, then, that at least some of those nasties are left in the beans when they cool.

However, whether drinking some coffee is always bad will depend if the linear no threshold hypothesis is true for roasted coffee beans?
http://minikanren.org

I was trying to come up with examples to demonstrate the value of lisp in my own work, but I think this one captures it better. Imagine being able to use your language to create a language, that still interacts with everything else, and express it so clearly that people can translate that into dozens of other languages.

If you were to write that initially in Java or C or something it would be hard to separate the essential complexity (the problem of solving relational problems) from the accidental complexity (managing the underlying language's semantics and data structures and such) while keeping the entire code base clean and clear.

Lisps do a better job of eliminating or reducing accidental complexity compared to many mainstream languages, especially the enterprise-y ones like Java and C#, which are commonly used in CS education unless you're at a unique school or one of the top schools in the US (without experience, I can't comment on what non-US schools teach).
This is exactly what StackOverflow highly encourages new users to read before asking questions: https://stackoverflow.com/help/how-to-ask

Sadly, some/many don't and then complain because the community is "unwelcoming".
IOS has always done a lot more with less memory than Android, by design. No JVM, lots of memory maximizing OS features.
The Matrix came ~9 months before Deus Ex, so their productions definitely overlapped but they'd have had time to assimilate some stuff if they wanted to.

That said, it's more that they're both drawing on similar cyberpunk traditions. There's a clear line between the aesthetic of Neuromancer and Deus Ex / The Matrix both.
HashiCorp Cloud Platform
As some other replies pointed out, there are straightforward modifications to handle all those scenarios if those are your requirements instead. A place where regex _does_ fail is in arbitrarily nested string interpolations (the key being _arbitrary_ nesting because with enough time anyone can come up with a convoluted enough regex to handle a bounded degree of recursion).
Another way to reduce the acidity is to mix in ground up egg shells into the ground coffee. As you brew this mixture, the calcium carbonate of the egg shells (alkaline) partially neutralises the acids from the coffee beans.

You can even combine this with the two usual methods for low acidity coffee that you mentioned (cold brewing and using dark roasts). I haven't actually tried this combo yet but I'm keen to!
I've been surprised there isn't more of "Call graph" automatic generation for code. I would have thought having a visual representation of which functions call which functions can in some cases help tremendously.

I started working on TypeScript Call Graph to see if it's useful -- an experiment of sorts [1]

Could anyone chime in about call graphs and whether they are useful?

[1] https://github.com/whyboris/TypeScript-Call-Graph/pull/1
I read the book "Never Home Alone" [1] last year. It's about all the tiny critters that are around us all the time without us noticing them.

One of the things the author mentioned that stuck with me is never to assume that something you find has been documented and studied before. There is a whole lot of world out there, and only so many scientists.

I believe one of the anecdotes he shared during that part was some high school kid that decided they were going to find a new species of insect. They went literally out into their yard and managed to find a novel species of butterfly or something like that.

A very interesting book if anyone was looking for a recommendation.

[1] https://www.goodreads.com/book/show/39088985-never-home-alon...
I'm glad you made the flat earther connection here. I was thinking the same thing and you validated my thought process
This experience is highly atypical. You can’t get this just by “treating” it differently. The current bullshit situation is a stable Nash equilibrium. Of course, if you should have certain advantages, you could sacrifice those and change your payoffs.
If you enjoy learning more about this sort of stuff, I'd highly recommend "Atomic Adventures" by James Mahaffey.

The book recounts all sorts of crazy nuclear research, mostly from the 50s-70s, including using entirely unshielded reactors to test the effects of radiation on various materials, and attempts to build a nuclear-powered jet.

https://www.amazon.com/Atomic-Adventures-Islands-Forgotten-I...
I've watched this before. It would have been so great to be in some of these classes and a Course 6 student there!
College is a huge scam imo. Paying thousands of dollars for a class on calculus that has 100 plus people in it is robbery. You can easily get that knowledge online for free. The only reason to go is for the piece of paper.
Lots of companies have directors from a wide background.

In Theranos' case, the fact that Kissinger, Mattis, and Schultz were on the board was probably more useful to Ms. Holmes than having some reality-center doctor investors.
you are right. But i need to fix my smoking addiction :/ .
I dealt with this for a while too. My solution was coffee (double double) so kept the sugar, but slowly went to black. I won't even go into a convenience store when I pump gas anymore, the cravings have stayed and its a battle everyday.
How do you get that? The FED is mostly just buying our own governments debt through treasury securities and citizens home debt through mortgage back securities [0]. They haven't touched equities and have barely purchased any corporate bonds.

[0]: https://www.federalreserve.gov/releases/h41/current/h41.htm
I'm not sure how Bitcoin, being a domain of shady consolidations and market volatility, is any more glamorous a representation of capitalism than Wall St.
> We won’t be shaken down for 30% of our revenue

Cough, only 30% for the first year of app sign ups, after that it’s only 15% (so really it’s just 15% unless they plan to run away after 12 months), cough, also not all your revenue, only those who have not signed up and subscribed via the website first, which is probably going to be the vast majority of customers of this service.
Anecdotally I have required antibiotics once the last 30 or 35 years so I doubt I would need it any time soon and if I need it I do not think I would be able to self diagnose reliably. Maybe I am an extreme outlier but I do not think taking antibiotics is common among my friends and family either, other than a friend who has chronic ear issues.

Personally I think antibiotics is one of the cases where having a gatekeeper is the most important since we must fight antibiotics resistance.
There is an interesting parallel drawn by a famous theologian: sin is self curved in on itself.
That was Apple's initial attempt, but the pushback was fast and furious. Spotify, especially, led the charge that this was ridiculous and Apple relented pretty quickly, IIRC. Now you can charge more to cover their 30%.
Everything about the internet is highly decentralized. There's no single point of failure, no truly critical infrastructure.

At best, such an attack would be nothing more than an annoying inconvenience.
IIRC the number of raw crimes is comparable between Western Europe and the US, but in the US the crime is WAY deadlier due to all of the guns. Canada is somewhere in the middle.

It’s hotspots. Take out Chicago, Detroit, Washington DC and maybe New Orleans then even gun crime in the US is no worse than Europe.
Here's the problem: you cannot guarantee equal outcomes across intersectional groups. Period. Not going to happen. A hundred years of psychometric research backs this up; there are simply differences that cannot be papered over by adjusting metrics and applying equalizing coefficients.

A highly effective education system that really gets the best out of every person involved is also going to be selective, it is going to group people into different classes based on ability, and the resulting output is going to be highly offensive to the militant people who right now are literally doing their best to take over American cities.

So no, we can't fix this problem. We can spend more on it, but ultimately all of that money is just IOUs against a decaying system that demands everyone be equal, even if that lowest common denominator means all but the super-rich end up living in a favela within a few decades.
I'm not a lawyer. If someone wants me to sign an NDA, I have to read it, sure, but I also have to hope that they haven't snuck something in that I won't understand but will screw me over later. The Waypoint NDA prevents me from having to hire a lawyer to make sure their NDA isn't hiding something; all I have to do is a word for word diff.
I have another pet theory for coffee: habitual coffee drinkers are uncomfortable with the idea of it being a vice, and so they conduct study after study to highlight the benefits, thus rationalizing their consumption.
Did the same thing in a game I'm working on, although it's in the backend.

Needed to store millions of routes that had a list of step objects.

Reduced memory usage by an order of magnitude by making the route a list of numbers, since you get rid of all the 8 byte pointers.

https://blog.winricklabs.com/(02-17-2020)---efficient-data-s...
I found this helpful when I was integrating visual sitemaps with documentation. They have a few different examples for different styles some don't even require JavaScript.

https://www.cssscript.com/clean-tree-diagram/
Going to university requires more privilege than learning from a book.
Although "learning styles" are widely believed by teachers, there's no evidence that they affect learning. They're basically horoscopes--vague enough to make sense on an intuitive level, but false [0]. In practice, tailoring lessons to this belief reduces effectiveness [1].

[0] https://www.theatlantic.com/science/archive/2018/04/the-myth...

[1] https://www.apa.org/news/press/releases/2019/05/learning-sty...
Everyday words that mean something else to programmers. First 65 tell a story
More like a drunk story.
Agree/disagree, but after doing SICP myself, following other methods and making projects at the same time (or working on things I was interested in) forced me to learn a lot more than just doing some assignments in a language I would never use again.
I assume you include anti-white racism? Because there seems to be a lot of it about at the moment.
It's the same here in Sweden. We have degrees called Högskoleingenjör (which is three years) and Civilingenjör (which is five years) that put more focus on practical and industry-relevant courses than the more science-focused Bachelor of Science and Master of Science programs do.
When you are making pupils memorize sequence of popes and are spicing it up with anecdotes taken out of their historical context just to be interesting, imo, the solution is not to have them play game.

The solution is to work on curriculum and textbook some more.
Fujitsu has been building its own HPC CPUs, for a long time, whether they use the ARM architecture or SPARC doesn't probably matter much for them. They know how to make them fast.
Seems like a marketing ploy. Everyone is cutting spending right now due to the economic downturn. What better way to cut spending you were going to cut than turn it into a publicity stunt that translates into likes on Twitter!

Great time to buy outdoor apparel ads on FB, btw.
Your body can definitely handle fasting for half a day. Frankly eating gives your body more things to be weird about.
for what is worth this has been known for a while (lookup Stanford medicine study). what’s interesting is that 4-5 cups per day is better than 1-2. also there is speculation that it’s not the caffeine but other things in coffee that have beneficial effects.

i also suspect that large coffee consumption is better if you compare people that don’t get enough sleep (as someone that does not drink coffee will have a better quality of sleep - unless you drink 5 cups in the morning)
How about this hit?

https://www.theamericanconservative.com/articles/rolling-sto...
how good is your AI so far?
Psilocybin (from mushrooms) and MDMA are both fast tracked for FDA approval as adjuncts to therapy. Psychedelics are poised to become the most common psychiatric treatment in the world, with ongoing trials showing huge effects for treating PTSD, addiction, and treatment-resistant depression. Despite a lot of therapeutic promise, LSD has not received as much research attention, primarily because of its duration of effect. Having therapists present for up to 24 hours (compared to 6 for psilocybin) is prohibitively expensive. A true off switch would facilitate its study and use in treatment.
A tracking pixel cant possibly tell you if the email was read. It might tell you if it was opened, assuming that it works correctly, but cant differentiate between loading and actually reading. It also might fail to tell you it was opened, for example if the user blocks these trackers.

All in all, its a lousy system. If you absolutely must be sure someone has read your email, you might need to call them.
The Onion's take on crows research:

https://www.theonion.com/researchers-find-crows-smart-enough...

"Researchers Find Crows Smart Enough Not To Let On How Smart They Really Are"
You do however pay the retailer something. Also, the physical retailer doesn’t provide you in further infrastructure - automatic updates, notification support, a printing press to help you create your magazine (ie developer tools), etc.
It is currently 10 cents an hour flat rate for the control plane. That actually saved us money. Even if you weren't going to run in HA, that is still the cost of a smallish machine to run a single master. I am not sure who running K8s in production would consider that too high. If you are running at the scale where $72 a month is expensive or don't want to run HA, you might not want to be running managed Kubernetes. I'd just bootstrap a single node then myself.
I'm OK with sugar-free being taxed as well. Sugar-free drinks that have artificial sweeteners are still sugary-tasting drinks. I think it is actually better overall if folks drop most sugary-tasting drinks in everyday life and save them for occasional use. I'm going to guess this sort of thing (all sodas) probably makes it less cumbersome to follow and as well.
To be even fairer, I've served a shit ton of traffic on a small DigitalOcean droplet and never had issues because my stack is reasonable.