skysight-inc/HackerNews huggingface dataset:
But in certain fields this current setup seems to be failing. The large majority of clinical trials related to neuroscience fail. To the point that pharma companies are starting to defund these departments, because the hit probability is just not good enough to outweigh the costs. This is despite the fact many of our treatments are woefully inadequate and often closely related to drug discoveries made 50+ years ago. And despite the fact that the field is well funded in academia, taking up entire departments distinct from biology.

Neuroscience is a hard problem no doubt, but I also think the current paradigm for how basic neuroscience research is done is way too limited, and that is impacting the viability of potential treatments that make it to clinical trial phase.
You don’t need to convince existing developers to adopt it. Remember the early web spirit, where people imagined that everyone would run their own server and publish their own homepage? Turns out it was way too complicated to do, and required you to be a tech enthusiast. Largely, I would say, because HTML was not designed to accommodate for a lot of the things people immediately wanted to do. Even a basic thing like keeping navigation consistent across the multiple pages is impossible.

I think if you designed a document language that took advantage of 30 years of experience of what people actually want to do on the web, you could find an entirely new set of users. People who want to feel ownership of what they publish, want to be able to be creative and improvise, but don’t have the technical skills to create a site in the current web stack. It would probably look more like a social media service, so it could run on top of the web as it is now, or have dedicated native clients.
There are a bunch of things which can differ between architectures which can't be reliably abstracted away by the standard library.

Memory coherency is one. Check out the table of what reorderings processors are allowed to do:

https://en.wikipedia.org/wiki/Memory_ordering#In_symmetric_m...

x86(-64) is very conservative, doing very little reordering. ARM is much more liberal, doing lots of reordering. The standard library may give you tools to write code which is correct across all architectures, by defining some portable memory model and then implementing that model on each architecture (in C++, std::atomic does that). But it's easy not to use those tools properly: you can write code which is incorrect according to the standard library, which works on x86 because it is conservative, but which fails on ARM because it is liberal. Detecting bugs like that statically is an open research problem, and cross-platform concurrency bugs are among the hardest there are to debug.

There's more than just reorderings, too. A local wizard tells me "On ARM, you can have cores where there is no implicit "propagation"... i.e. if you write to some memory location from core "A", core "B" may never see those changes. You have to use synchronization primitives to make changes visible. This also means that the old dirty trick of volatile instead of proper synchronization can definitely fail here.". My guess would be that cores like that won't turn up on Apple laptops, but who knows.

Another example is vector operations. If you want to make use of explicit vector operations, rather than relying on compiler autovectorisation, you need to write code around the shapes and operations supported by the processor. Those are different on ARM and x86 - although i think the instruction set on ARM is better-designed than that on x86, so at least it might be easier to port from x86 to ARM than vice versa. Still, here's a taste of the sort of work it takes to make vector code work properly even on different ARM chips:

https://www.cnx-software.com/2017/08/07/how-arm-nerfed-neon-...
Wow, apparently Imgur is now redirecting their plain image links to pages which _do_ require JS for viewing. Thus, Imgur has now been removed from the list of image hosts that I use (and I suggest others to do so as well)

Instead, here's the actual image, without any the JS: https://i.postimg.cc/hjzXvrNc/yvA5Eiz.jpg
HashiCorp Announces HashiCorp Cloud Platform
My concern from a priority and law enforcement perspective is that in the post-9/11 world, a great deal of funding and effort was put towards deterring and combating the latter.

Whereas something that is well known and homegrown in the USA (Timothy McVeigh, anyone?) has had a much lower level of concern assigned to it until very recently.
The big cities are the ones most known for being terrible because they're big: reputational risk is always higher for bigger organizations than small ones, because it's easier to be aware of the problems in one big org than twenty small ones that add up to the same size.

This is because we extrapolate any incident within the big org to apply to the whole organization, whereas we obviously don't extrapolate out incidents in small orgs to apply to different small orgs.

So if you have 1 big police department with 5 fatal shootings, and 20 small police departments with 5 fatal shootings in total, all in different departments, people will think, "wow, that big police department is trash, but 15 out of the 20 small police departments are good! Small police departments are so much better!"
Throwing generalized insults is easy. Projection is a hell of a drug. I don't think it's constrained to cities. I hold to no ideology. I said the _worse_ of them are usually big blue cities.
Profits from job losses will finance government borrowing for covid-19 bailouts
The solution to population variability is not to use variable models. That just trashes your result set.

There are enough confounding, uncontrollable variables in biology already.
N.b. should read "Structure and Interpretation".
Incorporation documents, fundraising docents
The second page of this document provides some details in diagrams.

https://docs.broadcom.com/doc/1211168563383

I presume it wakes up the chipset to do most of its work remotely.
>> Food in supermarkets is often terrible.

Try the Waitrose. I'm Greek and the best supermarket taramosalata I've ever had is from Waitrose. To clarify home-made taramosalata is cream coloured, but taramosalata sold at supermarkets is always dyed bright pink, for some reason. And that includes Greek supermarkets. The only supermarket taramosalata I've ever seen that has the right colour is the Waitrose one- and it also has the right flavour and consistency. Well ish. Nothing can ever beat my yiayia's taramosalata, but it's a good approximation.

I assume their other "ethnic" foods are also of similar good quality (for mass-produced stuff). They also have sort of decent fruit and veg and their own brand of Duchy Organic farming produce (milk, eggs, meat, fish, etc) that is actually good.
Butterfly keyboard works fine for me. It's actually my favorite MacBook keyboard so far.
I'm almost halfway through this:
https://plfa.github.io/

I was auditing a grad class at UT that used this book, then corona hit. Still plan to finish it eventually though

I'm not even really sure where I would get started working on an implementation or working on a paper. Are these projects open source?
I’d like to see them explain the benefits of this over solar power. They write in the article that it’s much faster, but that’s true for all chemical propulsion.

The benefit of solar power is that it’s almost limitless.
Are they "real" though, iPad apps often feel better and smoother than desktop apps because you're not actually working with the real data they often downsample to fit within the small memory requirements.

If I drag a video file from my desktop into Premier then I'm actually working with that video file. If I open a video file in an iPad video editing app then most of the time that video file is then transcoded to H264 so the hardware acceleration can make it actually usable. Therefore adding a layer of compression.

It's not the real file anymore.
Thumbs up for esbuild, it's awesome.
Part of the problem is that cops are usually not living inside their precincts, and they are trained to think of themselves as bringing law and order to a lawless metropolis. This is, of course, silly nonsense, but they believe and practice it nonetheless. In this way, it's possible for rural counties surrounding a city to contribute cops, violence, and hate to the city itself.
If I recall correctly, most of the deaths in the St. Paul caves are from people starting makeshift campfires in areas without any ventilation. Seems to be backed up by this MPR News article from 2004: http://news.minnesota.publicradio.org/features/2004/04/28_ap...

Generally speaking, you don't worry about breathing in caves: if you can get there unaided, then so can ambient air. The risks are mainly when you're traversing a completely flooded portion of the cave (a "sump"), since you can't be certain that the dry passages on the other side have any exposure to the outside atmosphere.

Edit: You do have to be wary of rain and flash flooding in the Driftless Area. It's not fun to see little twigs and leaves plastered to the ceiling in, for example, Goliath's Cave, since it means that the entire system can flood under the wrong circumstances. Caves are great fun, but they don't mess around. I'd encourage anyone interested in caving to reach out to their local clubs; we're friendly! For folks in the US, the National Speleological Society maintains a list of "grottos" at https://caves.org/committee/i-o/grottos/new_grotto_page-v2.s....
A part of this feature Qgis is a great tool made by people who works on GIS with an involved comunity
How T. Rex conserved energy
Because antenna gain is a function of both the transmitter and receiver, and detection is different from getting a high-quality signal. Most high-power radio signals on earth are aimed at transmitting to fairly low power, small, cheap devices which need to recover a good amount of information from the signal. This is very different from the requirements of a radio telescope (which has a gain many orders of magnitude higher because it has a much larger space, power, and cost budget) detecting a signal (which requires far lower signal-to-noise than reconstructing something high quality from it).
A few people on HN get stuck on the debunked gang rape story, and feel that it destroys any credibility Rolling Stone had. (I'm not one of those people.)

https://hn.algolia.com/?q=rolling+stone+rape
Many of my former students had wildly inaccurate mental models so I built a platform that focuses on addressing that particular issue: https://wakata.io

It teaches JavaScript, but most mainstream programming languages have the same semantics. It's particularly challenging because building a good mental model of programming takes a lot of time and effort.
'Ring of fire' solar eclipse thrills skywatchers on longest day
thanks mate! I was already heading over to thepiratebay!
Deus Ex at 20: The oral history of a pivotal PC game
Is the BBC being paid for by taxpayers really a problem that people have? Seems like American "capitalism good, socialism bad" rubbish that non ideologues know to ignore. Why would the business structure of a website impact the quality of articles?
Sqreen for Go now protects against SQLi, SHi, LFI and SSRF
Seems fairly unlikely though.

Random bacteria and fungii that are introduced to humans don't kill us all off. Bacteria especially are everywhere, it stands to reason that over all of the exploring, investigating and just plain spreading that we do, we'd encounter some bacteria that are new to a population. If those had any great chance of killing us off, shouldn't at least local examples exist of that happening?

Instead I think what we see are the organisms that affect us are those that coevolve with either us or with related species. We're killed by the things we spend a lot of time with, not random out-of-context bacteria that's never seen a mammal before.

If that's true of us, seems hard to say why it wouldn't be true of aliens, no?
This article suggests it's likely Ketanserin. https://newatlas.com/science/lsd-off-switch-mindmed-liechti-...
It signals to a lot of us that there are very different rules when playing on the "elite" level of the economy. When you amass power enough through capital our current system definitely tips over to be lenient against them, and the longer I live the more I feel it's not necessarily by design but definitely this hole is left open in the capitalist system on purpose.

This is one of the reasons why I feel that over time I got very much supportive to "eating the rich", their power to skirt the law is way overdue to be corrected.
Just played it and it was quite fun in the begining. Skipped ahead to fractions via blue path, an issue which came up was it was easy to travel into dead paths endlessly navigating the sea or running around. Went back to beginning of level and turning right instead of left cleared that issue.
Another issue was that when moving back after an unproductive path, it is hard to see what was behind the character, you cant see a wall until you hit it. Moving the camera back helps.

But the game itself seemed very interesting.
More evidence that my circles were circumscribed, "poor white trash" used in 1860:

https://docsouth.unc.edu/southlit/hundley/hundley.html#hund2...

The author was more erudite than the current 140-character expounders of his beliefs, but these beliefs haven't altered much over the generations: poor people come from poor stock, our poor are better off than europe's poor, cities are the root of unrest, if you let people go after slavers they will go after capitalists next (massachusetts being the home of socialists and communists), etc.

If Hundley was distasteful, Isenberg has more modern sensibilities:
https://bookclubbabble.com/white-trash-vs-the-american-dream...

(To tie back to more usual HN'ish fare: the textile mills mentioned in the comment on that page were outcompeting the textile mills in Boston due to nonunion labour. Eventually the loss of the textile industry to the south would provide cheap office space for DEC.)
From a number point of view, you should be more worried about common crime than terrorism from any side.
The word "mismanagement" assumes it was meant to work. It wasn't. It was a bung to one of Cummings' mates to make an app to gather information on us, which didn't work, because people knew who it was from and didn't trust it. It was never meant to work. Just like the track and trace call handlers they "employed" to do nothing with no training, not meant to work. It's all about syphoning money off to their mates and the Russians.
>I would be stunned if there isn't an ARM cloud Photoshop ready to roll.

I would be stunned if Adobe was developing new ARM anything and not just working on webtech versions of their suite.

Figma has proven that it's more and more possible each year and as soon as someone gets it right for Photoshop/Illustrator etc then they'll eat Adobe's lunch.
> You don't develop cloud software on a mac anyway

You must be living in a different universe. What do you think the tens of thousands of developers at Google, Facebook, Amazon, etc etc etc are doing on their Macintoshes?
Don't hate on your code. If it runs and does what you want, then it's good code. Refactoring later can be useful and improve things like performance and readability but what matters is that it works.
I've never understood this argument. For some reason there is this RISC vs CISC war debate but it's not actually based on reality of modern day chip design. The idea is that the decoder is consuming too much power and this design flaw cannot be fixed. Simplifying the decoder reduces the power consumption and therefore allows higher clock frequencies. But when we look at the clock frequencies of ARM and x86 chips we consistently see that x86 chips run at higher frequencies (roughly 4 Ghz for x86 and 2.7 Ghz for ARM). If there is a difference between ARM and x86 chips then it's not in the decoder. The difference must lie in the micro architecture of the chips and therefore RISC vs CISC is no longer relevant because the ISA is by definition not part of the micro architecture.

Apple's ARM chips probably perform much better than reference ARM chips because they are much closer to the micro architecture that Intel uses. But Apple's chips still consume less power than Intel chips used in laptops. The secret sauce is probably the fact that the SoC has cores with different performance and power profiles. Big cores are used for peak performance bursts and lots of small cores for energy efficiency while the device is waiting for user input.

I think Geekbench is measuring peak performance and not sustained performance but the numbers are probably correct. Making a representative comparison between mobile devices and desktops isn't possible because their different thermal profiles but it's highly likely that Apple will go for a passively cooled design if they can.
Fixing Apple's Engineering in an Hour [video]
Kafka: The Rescue Will Begin in Its Own Time
When I go to Ruby conferences, Java conferences, academic conferences, whatever, in Europe, everyone - almost literally everyone - is on a Macintosh, just as in the US.
I imagine that “the fix” involves a new strain of more natural mice and a better breeding protocol moving forward. Part of Weinstein’s issue is that this fix has not been transparent. I hope someone can provide greater detail.
> To clarify, I am literally asking for a simplified threat model.

That's a simplification beyond any usefulness. You wouldn't be able to do as much damage with $100k budget in a few months as a well-staffed national agency in a week.

> The question is just me looking for broad strokes anecdotes.

Even Jeff Bezos wouldn't be able to orchestrate a cyberattack that crashes International Space Station with astronauts aboard.
They haven't publicized it because it doesn't actually do anything until you have an app that makes use of the API. If it's not turned on, the app will prompt you to turn it on when you install it.

I live in germany, where the app is already released -- the settings panel shows a list of installed apps that use the API, but the app is responsible for the synchronization of the randomIDs with the server, notifications, etc.
From a pure numbers/statistics point of view a great deal more people die from slipping and falling or drowning in their bathtub every year than are killed by either form of terrorism in the USA.

But we still should take efforts to reduce that, whether it's by building showers with textured floors and efforts to counteract terrorism...

https://www.seattlepi.com/national/article/Someone-drowns-in...
AFAIK all other touchpads still use a physical mechanism for clicks. I would not want to go back to that after getting used to the haptic trackpads.
That's the first thing I thought, too - sounds like they are trying to spin it as some malicious user "broke in". If a "customer user account" is able to upload a malicious payload and exfiltrate huge amounts of other customers' data, there's a much larger, underlying problem here. Hard to see how Netsential could get through this fiasco and still have any business.
all envisioned and positioned in the job era, got any post jobs example?
all envisioned and positioned in the job era, got any post jobs example?

and 2020 se is not a low margin example https://www.phonearena.com/news/apple-iphone-se-2020-teardow...
I worked for a global oil company a few years back. I had then and have now no misgivings whatsoever about that work.

I think the average anti-oil person living in a developed country drastically underestimates the centrality of hydrocarbons to our way of life, and the devastating impact on all of our lives of a rapid shift to zero-carbon etc. Think little food, modern medicine, sanitation, and drastically reduced opportunities for travel and education for example - this would resemble the lifestyle of someone living in Tipi Valley, which is the closest thing we have to zero-carbon in the UK as of 2020, and even they effectively still parasite themselves to a significant degree on the oil-driven economy.

I'm all for protecting the planet but the answers are so complex, and oil - being such a wondrous substance with myriad applications - is so tightly woven into our lives that it will take decades to unpick the linkages, and in many cases this will likely not be possible unless we really are prepared to accept giant steps backwards for civilisation.

That said, I'm all for tackling the worst excesses immediately. We could start with swingeing punitive taxation on Canada and Germany, for example, for tar sands and coal respectively. We could also introduce a complete ban on the use of oil in favour of LNG for marine transportation.

Edit: I think this piece is remarkably smug, judgemental and bourgeois in tone, and specifically as regards the military/police aspects, I'm reminded of the quote attributed to Orwell (that may or may not be accurate, but sums up my feelings well): 'People sleep peaceably in their beds at night only because rough men stand ready to do violence on their behalf'.
> I also think the current paradigm for how basic neuroscience research is done is way too limited, and that is impacting the viability of potential treatments that make it to clinical trial phase.

Our current paradigm is optimized to avoid injuring humans at all costs, including to the extent that it diminishes the chance of success.

By advocating for a different model, we're stating "Avoiding injuring humans in drug discovery is not our primary concern."

Maybe that's worth it in a broader calculation, but let's be honest about what we're talking about.

Pharma companies and regulatory bodies don't put in place billion+ dollar trial hoops on a whim: they do so to avoid permanently injuring or killing people with some pretty horrific side effects, to the extent we can.
What about legacy software and software provided by a vendor? Let's say I want to run Fusion 360 and Altium on my hypothetical ARM Mac. Can I do that today?

Outdated information: Windows on ARM requires you to build UWP apps which is more work than just a recompile.
Seeing how identical individuals from literally the same cell line in an exactly identical and controlled environment sometimes give different results I don't think you can ever achieve 'perfect controls' anyway. The solution is to delve deep into what things actually do (in the case of people I know, that involves a lot of live single-cell imaging and suchlike) but that's expensive.
For relevant reasons, I'm more concerned about having my hard-earned money seized through civil asset forfeiture than my house being robbed by some random criminal.
The article says it is about getting to "close" destinations, like Mars, as fast as possible. I am not sure how solar would achieve that over short distances.
This won't expose cops planting evidence, it's more like 10,000 criminals going free, and your direct example isn't related to this story.
> This doesn't make sense. How can you search for a string if you're already in a string? I can't think of a realistic situation where that would be useful or even really possible.

query = "select * from table where name like \"%foo\""
>I’d like to see them explain the benefits of this over solar power.

One big problem with solar energy is that it is a diffuse power source (i.e. energy per unit area is low), and gets exponentially more diffuse the further from the sun you go.

The second is that though solar energy is limitless, the components that need to use chemistry to turn solar energy into electricity, are not.
> Either way, put the same chip in a Macbook and in a Windows laptop and the Windows laptop will run hotter but with better performance.

The Windows laptop can't possibly run hotter than a Macbook, all of which reach the throttle temperature (~100 °C) almost instantly.

I actually agree to the artificially limited performance, artificially worsened thermals theory. The Macbook Air design is extremely fishy.