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As a 'budding' herbalist (sorry bad pun), I'd almost be willing to make my own tincture of this drug. Websites out there are doom and gloom only because you need to talk with a real herbalist about the proper mixture and technique in which to extract the chemicals.

This Google Books link seems to give the appropriate amount of drops per hour, which passes my BS detector. But like I said, you need a real herbalist for guidelines for making the tincture, or buy it from them.

http://books.google.com/books?id=gDLIrCv26hkC&pg=PA272&#...

http://www.aminaherbs.com/product.php?id_product=91 Also sells the seed, as do other sites. I just found this one due to the bulk nature that they sell in. I have no clue if this company is good, but just wanted to show that it is easy to buy.

Lastly, I thought this was some sort of sick "April Fools". Come to find out that this is normal FDA business with corporate profit extraction.
This is one thing which can happen when you put all your data into "the cloud" and hope for the best. One risk which any business has to take into account is the possibility of a rogue employee or ex-employee running amok. Putting all your eggs (or data) into one basket, especially when that basket is administrated by people who don't particularly care either way what happens to your business, may not be the wisest strategy.
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"Well, it's official, I take it. Android has won. Google has overturned Microsoft. Microsoft has now waved the white flag and admitted it is an also-ran in search and in mobile, and that it can't win on its own merits without outside help from regulators. That's what I get from its latest move, filing an antitrust complaint against Google with the EU Commission"

"So frankly the flood of complaining about Google looks to me like a coordinated campaign. There. I said it. I think reporters should research that and write about it next. I'll bet you hit pay dirt"

"And speaking of Microsoft and antitrust, did you see this deal, the French Defense Ministry buying from Microsoft Ireland instead of from the US? Is that legal?
How about the state laws Microsoft is lobbying for these days? Are those laws Constitutional? Even minimally fair? Anybody looking into that?"

Microsoft: bad software from bad people.
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I've got to try this. I love it when people come up with really original stuff for the iPad like this.

edit: bought it, great fun. the touch interaction works the way you need it to (ie. more advanced than most touch apps) so you can come up with lots of different techniques to beat the levels. when you get cut it does cause a slight 'aaaahh!' reaction and withdrawal of fingers. you get kicked back a level if you get cut, but hey, no pain no game.
In MacVim I tend to switch between molokai and ir_black.
I dont know of a business model, but a TCM practitioner would fit the rest of the criterion.

Many of the plants used in traditional chinese medicine are extremely dangerous to use otherwise. One I know, if injected, causes death. If you breathe the smoke of the same burning material, you cannot speak. But just like all drugs, they have their intended purpose if used wisely.

Now, how about would they get around the FDA? It's simple: It's the chemical application of the Tao Te Ching. It's cheap, but pull the "spiritual and religious" card.
I just wanted to say that -- wow, this is one beautiful site design. Sorry it didn't work out so far. If you end up giving it away, I hope it finds good hands!

That said, I hope the two of you can take long vacations, find new energy, and that we'd see a "How we got 1000x users" type of post from you in the future months.
Also a nice segment with him on NPR:
http://www.npr.org/2011/02/23/134003962/Moonwalking-With-Ein...
The "today's featured article" bit is probably not a joke. 18th century london was actually like that.
Assuming this is not an April's Fool joke: This is actually a very nice idea. Keep a small share and let other people run it. I hope someone skilled will take over. Please keep us posted how it went. Also I like your "Help us get featured on", idea. You're very clever marketers indeed. :)
Roaming data charges marked up more than cocaine (79,000% vs 32,000%)
There are a bunch of other techniques like this (which I've used with occasionally surprising success) at http://www.ludism.org.
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You do not seem to understand orphan drugs or this article. Basically every word of your second paragraph is incorrect.

These are drugs that have never been approved by the FDA. No manufacturers were previously approved and no standards have been changed.

The FDA wanted clinical trials on the drugs. There are incentives in place to encourage companies to develop drugs for rare conditions where there are not enough patients to warrant investing in for economic rewards (and yet you envision companies in competition over them). These include grants for the required trials, tax credits for half of the cost of developing the drug, and a seven year monopoly on the drug.
I get saddened everytime I see this old story of greed and indifference. I've had a personal run-in with it myself: for years, we Scandinavians with sleeping disorders could enjoy Melatonin from several different producers to a very low price. About two years ago a company called Nycomed managed, with lies and deception, to get a monopoly on selling Melatonin in Scandinavia by convincing our governmental medical products agencies that Melatonin was harmful and had severe side-effects - of course, all Melatonin but their own magic kind, marketed under the name Circadin. Before their "coup", I could purchase 30 tablets á 2mg Melatonin for €5. Nycomed wants €22 for 21 of their 2mg tablets. We're close to a million people here in Scandinavia who rely on Melatonin daily to get our sleep. Why did you let this happen to us, Scandinavian MPAs?
April Fools, I presume?
+1 for zenburn
Don't do it.

Might be a way to encourage them to pay you, but to your prospective clients who don't know the backstory behind nonpayment, you will seem petty and vindictive. Maybe you didn't deliver as promised, or the bill just slipped through the cracks by accident by ending up in the engineering department instead of accounts payable.

The facebook/twitter route is a public record, not only for the client but for you.

Do what's right for you, not what's wrong for them.
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Where do I think he went wrong? Passing out the hats. I was fine up until that point. This isn't for a GoDaddy commercial. Sheesh.
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Great article Ruben. I've been trying your method out for the past days, but the problem is I don't often have to remember things. I wonder if methods like this one are getting irrelevant in the days of computers and smart phones..

Probably the most useful use case is when you have to shop for groceries in a supermarket. My SO, Helga, usually tells me what to buy and I usually forget everything. But lately I've just been typing everything into my phone and that works. This method might work for that as well - Memory Supermarket, anybody?
I like the "Help us get featured on" with all the logos, at first glance it probably looks like you've been on all those, creative!
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Yes, if you run through the memorized list once a day, in a few weeks you can free up that parrticular palace for other work and keep the memory --- you've memorized by rote.

As for scale, many memory workers use a linked list as well as the memory-palace array. Associate each item with the previous item, and you don't need 10,000 room palaces; just someplace to put the head of the list. That's how I memorize decks of cards: http://blog.diiq.org/post/3366119815/what-are-the-step-by-st...

An excellent resource is Lorrayne and Lucas' The Memory Book:http://www.amazon.com/gp/aw/d/0345410025/ref=redir_mdp_mobil... , which has been lifechanging for me.
It's both. The "DNF" header can't be a serious proposal since it doesn't follow the convention of other HTTP headers. They're leaving "Do-Not-Fool" unused in case it later becomes a serious proposal. But it does actually send the header, so in that sense it's legit.

Announcement for our DNF support: http://ourdoings.com/2011-04-01
Not sure if this is supposed to be an april fools joke, but the post title statement is false, in mandarin and in cantonese.

穀歌; pinyin: Gǔgē
I don't think you understood what he was saying.

In effect the FDA set a ~1 billion dollar bounty from doing 2 study's on this drug. What was not said is there are limited resources in the industry so while this company went after this fairly safe and profitable drug plenty of other companies went after other drugs and there is no incentive to research the same drug as another company. This is a land grab plain and simple and only an idiot would think a company would act any differently.

PS: And when you realize the only thing patents gained from this was higher prices you need to conciser it poor regulation. (1 study of 200 people says next to nothing about a drug regularly taken but 10's of thousands of people for hundreds of years.)
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One step further... using body movements...

http://mail.google.com/mail/help/motion.html

"Create a flowchart with ease" :-)

But is the undertone a suggestion that Kinect just isn't going to make it out of the world of gaming?
It's no April's fool joke! Thanks for the kind words :)
When he writes about this sort of thing Derren Brown (British mentalist) mentions that once you get to a decent level of skill with this you can just make up new rooms in your head; he talks about "dropping" overused rooms and starting fresh ones.
That will print the whole file regardless, I think you meant:

perl -ne 'print if /regex/' file
For be fair, I think Goldman was named by Bud because of their relation to this story.

> Insider trading is a criminal offence

The update in the article suggests that the trades may have been done prior to any non-public information about Goldman's valuation.

BTW, there is a good discussion about the (il)legality of insider trading for privately held companies over at Quora:
http://www.quora.com/Do-insider-trading-laws-apply-to-privat...
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Ha ha, ya it works for me. Up or down in less than 15 sec. That's all I really care about.
A few years ago I got decent at a similar method so I could memorize a list of 20 items pretty quick. I thought I was the cat's pajamas for awhile until it dawned on me that I had never used it once outside showing off the trick. I've since lost the skill from non-use. Not to troll against the post or the poster, just my personal experience data point. But hey, I love seeing and learning new party tricks, so don't let me discourage anyone from trying out interesting things.
Just disabled it. Thanks for the heads up.
Sounds cool. Makes my hands feel uneasy just reading it.
> The "DNF" header can't be a serious proposal since it doesn't follow the convention of other HTTP headers.

Why do you say that? The Do Not Track header (which is of course quite serious) is "DNT".
I'm pushing it on Github and I'm also coming to the States before Summer. Sure, I'll find nice people to help me fix up the copy!
*assuming this is not an april fools joke

I don't usually login to post, but I just wanted to say, although I do not know your situation at all, if you're putting it up due to burn out, please take a second look and make sure what you're doing is for the best. Startups always have their down cycles, so I would hate for you to give away your company if it could be retained in some way, as burn out / down cycle are problems that can eventually be fixed.

I say this as I was on the brink of shutting my own startup very recently before I found my passion and drive for doing it again (after a burnout that took 8+ months to recover), and I'm very glad I ended up sticking with it.
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This doesn't look like a solution. Looks like a sales pitch... FAIL.
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I looked into that, The 98cm max-height doesn't work for me. I'm 6'3".
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It sounds more like cross site scripting to me than SQL injection. In SQL injection you try to coax a database engine into performing a previously unintended action by carefully crafting content that is part of a query.

If this attack works by storing the data in the original (intended) field and just happens to bypass the JavaScript filters then it's XSS and not injection.
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Read the entire article.
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I'm curious if this has any negative impact on the accuracy of long term memory recall. For example, I can imagine that I would place these exaggerated items in a friends house...then, years later, in a discussion with said friend; "Hey, do you still have that SD card bed?"
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Lying about a highly dangerous 0-day in a very widely distributed piece of software seems in bad taste, even for April Fools Day.
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particularly when you also implicate someone specific in the process.
Who says he only deleted a single file? It's not hard to delete stuff from online backup systems.
Since nobody else has said it, I'll take it!
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TechCrunch is making a big list too!
http://techcrunch.com/2011/04/01/april-fools-2011-the-big-li...
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I'd never heard the Openheim quote, but it certainly resonates with some ideas that I've toyed with for some time now.

The best part is, it applies to other things than just happiness. Success, for example. You don't get to success by sacrificing everything for its sake - on the contrary, you get to success by taking on a successful mindset, growing yourself into the kind of person who is successful, and letting your activities flow from that. When you find yourself sacrificing everything for success, you're probably heading for failure.
Who did the screenplay and video work for the demo?
LiteralNet is in full force today, I see.
Indeed.

The danger is that people will read "0 day" and start freaking out. If you actually read the post, you see a couple warnings signs:

1. They claim it's part of a larger conspiracy and that people should sue Automattic.

2. The "vulnerable" filename is wp-att.php, as in AT&T

3. They point out that the MD5sums to trigger this behavior come from the words "remote_control" and "nsa"

But even noticing that, I still felt the need to log in to my server and make sure the file didn't actually exist; when someone cries "0 day", it would be irresponsible of me not to, no matter how crazy they sound.
Oh sure another taxpayer funded job-killing GOVERNMENT agency. Don't you understand that the private sector, in combination with absurd patent/monopoly incentivization, is the ideal solution to all human need?
There is no wp-att.php ;)
That is beautiful site design, and I'm thinking this is an April Fool's day joke!
MICRO-optimizations? Check some perfs: http://jsperf.com/my-js-perf-tests! There is still much to do for my.js to become mainstream. I may write a plugin for jQuery but for the moment I want to let my.js grow and stay independent. I think that my.js bring new concepts on the table that can't integrate in the main other frameworks without changing their core.
Ha! rtm, one of the YC partners, is mentioned in the "Did you know" section.
OK, if that was April Fool's, it's in very, very bad taste. People like me who aren't hackers or technically savvy will take it seriously. I tweeted it around. At the end they could have at least said April Fools, FFS!
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This is more/less common in certain industries, and perhaps partially based on regulatory issues too, although I'm guessing there.

I have worked on financial software the majority of my career; at one point in a Wall St. investment banking firm. The very explicit protocol there was if you were going to leave the 2 week notice was customary, but you would probably be locked out of everything instantly, and would be around for hands-off consulting at the whim of your manager for the duration. It was all handled very professionally and friendly, at least for me, and they let me keep working for the 2 weeks since anything I touched had a LOT of layers to go through before it ever saw production data.
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Hmmm, it seems pretty similar to one from a while back http://news.ycombinator.com/item?id=1390147. Maybe this is an April Fool's joke though. Anyways I can always tell when my girlfriend's period starts, but I think her mood change is partly a psychological reaction to the physical symptoms rather than just a "hormonal rollercoaster" as they're claiming.
i like the "help us get featured on X"....at a glance it looks like you already were
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Street magic with functions - the video of the talk I gave at JSZurich meet-up
We use Redis and MongoDB for two different purposes.

Redis is used for our messaging queue (resque), sessions and caching. MongoDB is used to store our user data. Redis could be used to store our user data as well but we feel that MongoDB is a lot easier to work with because of its query language.

MongoDB fits better to store our user data and Redis fits better for our messaging queue, sessions and caching. We have yet completed migrating from MySQL to MongoDB which is why I've listed both in my post.
I can't vouch for anyone else, but there were no comments when I originally looked at the post.
There's a book by Jonathon Spence called the Memory Palace of Matteo Ricci, describing the life of an Italian Jesuit who lived in China and was an advisor to the court (I can't recall if it was late Ming or early Qing, but it was in the 17th century). Besides sharing advanced Western science and artistic techniques, another way in which he and other Jesuits inserted themselves into the life of the court was by using the memory palace technique to learn spoken and written Chinese, understand the cultural and social aspects of the court, and impress the court officials with some incredible feats of memory. One trick I remember involved reciting a long passage of Chinese backwards after hearing it once, which utterly astounded those in attendance.
There's April Fool's jokes, and there's "seriously nasty month-ruining unpatched exploit in the wild". This is not a good example of the former.
Wow, what a waste of everyone's time:

> [UPDATE 3/31/11: Mich Kabay writes: A Samsung executive personally flew from Newark, N.J., to Burlington, Vt., carrying two unopened boxes containing new R540 laptop computers. These units were immediately put under seal and details recorded for chain-of-custody records. At 17:40, Dr Peter Stephenson, Director of the Norwich University Center for Advanced Computing and Digital Forensics, began the detailed forensic analysis of the disks. We expect results by Monday.]

http://www.networkworld.com/newsletters/sec/2011/040411sec1....
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It's not :)
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Oh thats right it is April 1st.
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almost fell for it.. well done
Unrolling that inner loop in the Boyer-Moore algo is called "Duff's Device".
This is actually an awesome idea, not just for April Fools.

We just need the NY Times external IP pool ranges and all the bigger sites should do it for real as a protest.
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Very true. This raises another question as well.

The various hurdles imposed by the FDA raise the cost of drugs. Various proponents of the current FDA regime tell us that this is necessary, and that the cost increase is worth it for the FDA guarantees of efficacy and safety.

Will those proponents now come out and defend the FDA in this instance? Will they declare that the new safety guarantees given to patients are worth $2.40/pill?
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expensive ? seems it would be to get them to produce a video ? are you able to share the cost ?
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It's a clever gag, but titles like this will unfortunately show up in future HN searches.

Would it be appropriate to adopt an April 1st etiquette of some sort? Say, an [April Fools] tag in the title?
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Its clear now that Amazon will soon be launching their own Android phone (to go along with their App Store). And with NFC brewing in the background - doesn't it make more sense for AMazon to buy T-Mobile (intead of AT&T)
Surely there will be two different retail names for it. OldDrug X and OldDrug XLI, or whatever.
Here are some additional ones: http://techcrunch.com/2011/04/01/april-fools-2011-the-big-li...
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