> No point in focusing on hormones so much. I somehow don't see people fretting over their ACTH or progesterone.

I respectfully disagree. When I go to USA or Mexico in particular, the frequency of obesity is astonishing. Perhaps with more understanding of the mechanisms around the phenomenon, there would be more success in dealing with the problem. As I mentioned earlier, around 25% of the entire human population has NAFLD, which is also an astonishing figure.

I'm not saying that every person must study these metabolic pathways in detail, but rather that the quick and simple rules and choices people make in daily life should take advantage of what is known, hopefully for a better outcome than what is currently observed.

> insulin IS NOT needed for glucose absorption

I'm not aware of anyone claiming insulin is needed for glucose absorption. The brain, liver, and red blood cells, for example, cannot function properly if they are sensitive to blood insulin levels; this may be because the RBC and brain rely on a steady supply of glucose, and the liver must be able to take up or release glucose on its own schedule.

On the other hand, muscle and adipose tissue DO have insulin-sensitive GLUT4 transporters. The GLUT family of transporters are passive, so glucose flows down its concentration gradient, unlike the sodium-linked transporters of the gut and kidney, which actively transport glucose against a gradient.

So in the case of adipose tissue, it does require glucose in order to store fat. The glycerol backbone for intracellular triglyceride synthesis is provided by glucose. In a person without diabetes, insulin is released from the vesicles when the body detects the amino acids leucine and arginine, or the sugars glucose and mannose. So typically, insulin will also be present, and having its usual effect on the GLUT4 transporters.

This is all covered, to some degree, in the appendices to Fung's book on obesity, by the way.

> Adipose tissue is [...] usually the least resistant to insulin and the least resistant to nutrient storage since it's its primary role. It will just pack more in.

Yes that is my point as well.

> P.S. Isn't Fung a quack? E.g. https://www.myoleanfitness.com/evidence-caloric-restriction/

No, Fung is not a quack.

It doesn't seem fair to even compare Fung's work with the claims of Myolean, because Fung is a trained scientist and knows how to read, interpret, and communicate scientific information in the traditional manner that others can understand. Even if Fung's arguments were wrong, at a superficial level he would be more persuasive because he knows how to use the language and standards of science.

However, examining the discussion in some details will reveal that Fung is correct in all the major points covering this topic, as best as is known at present. (Of course there are major unknowns when it comes to human metabolism, but there is also a lot that is known).

From the link you provided, it seems quite apparent that Myolean does not understand what a non-linear feedback system is (e.g. human metabolism), and doesn't understand the role of motivation and willpower (for compliance) involved in maintaining a calorie-deficient or calorie-neutral diet.

At no point does Fung say the laws of thermodynamics don't apply, but rather that they aren't very relevant when you incorporate the variability of basal metabolism, and motivation/willpower, into the model. One of Fung's major points is that in reality, when people try to follow restrictive diets, doing it in a way that leaves you constantly hungry, with low willpower, and continuously high insulin production leads to failure of achieving desired results.

Here is Fung discussing FFA [1].

[1] https://www.dietdoctor.com/fasting-and-cholesterol

Lastly, it would be easier to take Myoleanfitness more seriously if I didn't get the feeling they are trying to sexually manipulate me with a hit of dopamine and testosterone with their ads such as [2] and [3].

[2] https://www.myoleanfitness.com/wp-content/uploads/2018/05/Su...

[3] https://www.myoleanfitness.com/wp-content/uploads/2018/12/On...

The point is, the substance of the Myoleanfitness argument is not even wrong, its just irrelevant. But the form in this case matches the content. Distracting and irrelevant.