skysight-inc/HackerNews huggingface dataset:
> And yet we still can't show the drug works.

There has been just one trial done properly to my knowledge, and that was published yesterday. And even that is just applied in a narrow case (post-exposure prophylaxis, modulo some important study limitations).
Could this be used to run an iMessage proxy on a server?
GitHub Issues/Azure DevOps
Same here, as long as you have white backdrop (large poster board from an old school project) and are able to crop/print it to the correct dimensions there is no need to get a professional picture. When planning the family vacation, were looking for any ways to cut costs a bit
I mean, this is just a VM in a container, so you could totally make an equivalent running NT rather than Darwin in the VM.
"By 'X', I meant X" doesn't help to explain what you mean. Can you clarify?
Major Publishers Sue the Internet Archive's Digital Library Program
Researchers Retract Study Linking Malaria Pill to Heart Risk
Can You Violate the Geneva Conventions?
Same in Switzerland, alas it's the designated passport office and not a police station.

They have a specially kited photo booth, where you also leave two fingerprints for additional biometric verification.

In order to renew your passport you need to schedule an appointment withyour local passport office.

Last time I renewed, 2013, it took 7 weeks until the earliest available appointment, which was a bit surprising. I'm sure, though, there's an emergency shortcut for a price.

The new passport arrives two days later by mail.
https://erikbern.com/2016/12/05/the-half-life-of-code.html
https://datasette.readthedocs.io/en/stable/ -- i could've been more clear.
This would make sense to me. Why are some businesses being shut down and have to deal with income losses and others like landlords can keep going and demand their income? This seems fundamentally unfair to me.
It would probably be hard to find a rental during that period, as legally you wouldn't have to pay to occupy the space. Though landlords might be cash strapped enough to let you move in to get the down payment.
While this is a breakthrough within the field of cryo-electron microscopy it is important to appreciate that for many questions in structural biology we also need to understand how protein structure changes over time.

With the presented method the structure sampling time seems to be O(10 s) which easily is about 10 orders of magnitudes slower than the dynamics we're interested in seeing.

A direct consequence of this is that for achieving atomic spatial resolution they needed to use a "rock-solid" protein -- one that has an exceptionally stiff structure (one that does not wiggle a lot). The presented method is great and cool, but this is a pretty severe limitation. Most proteins wiggle a lot :-).

Background: protein structure-function relationship can often be well understood only when considering the structural dynamics of the protein (key words: conformational changes, the entropic contribution to free energy).

That is, in the ideal case we would be able to measure molecular structure not only at high spatial resolution, but also at high temporal resolution.

How can one make such a measurement much faster, by ~10 orders of magnitude? By irradiating a lot of light. Via X-ray free electron lasers (XFEL).

XFEL-based techniques are expected to revolutionize structural biology (as always, also still a long way to go):

> XFEL protein crystallography not only determines high resolution structures of proteins, but also reveals the time-stamped conformational changes of proteins.

- https://www.nature.com/articles/nmeth.3070.pdf?origin=ppub

- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678726/

(PhD in structural biology/bioinformatics, investigated dynamics of proteins with molecular dynamics simulations)
Corporations are people, my friend. /s
From tattoos to plastic surgery to prosthetics to pacemakers to organ transplants to hip/knee replacements, we are already hacking the human body.

How much further can we push it? I want to play.
Depends what means old document. My 8 years old induction stove glass surface broke by accident and I got full price money back from my home insurance. They were ok with photos of the device and pdf purchase receipt from my email archive.
> Its considered taboo to point out that income inequality is largely cultural.

I wouldn't say "cultural" because that's pretty loaded. My point is more that if there were something structural about the economy that kept people in their class (big banks, bad public education, etc.) you wouldn't see high mobility in certain sub-groups. There has to be other factors in play--who knows what they are. But I wouldn't assume they're necessarily "cultural."
Almost certainly since inception. They operate solely in prisons, as muscle, so any abuse charges are going to fall on deaf ears even if identified fully.
I did my undergraduate degree in Nutritional Science, realized I liked enzymes/protein structure a lot, and applied to a biochemistry department PhD program. I'm in my 3rd year and currently on/ahead of track so not having a biophysics background hasn't held me back.

I'd recommend, if that's what you wanted to do, to start with biophysics or molecular biology as those are the hardest aspects. A good computer science background is helpful as well, because a huge part is processing terabytes upon terabytes of micrographs into a finished, ab initio protein model. There's always room for new techniques there.

Personally, if I were to do it over, I'd major in the closest thing to biophysics/structural biology I could, and spend as much time in a lab doing undergraduate molecular biology research as I could.
Shopping, Data-centers, Live-Streaming, Audio-book's and E-books maybe even logistics.

Edit: Hey Jeff please stop down-voting me, you know it's the truth ;)
Perhaps you are thinking of xonsh https://xon.sh/

Edit: x1798DE beat me to it :D
Thankfully, this was discovered by some tenacious independent researchers. Does anyone have the scoop on who sounded the alarm how they were able to bring the issue to light?

Edit: So apparently this study was just a preprint and not even peer reviewed yet. I don't see why it carried so much weight in the media and WHO decision if that's the case. I think it's probably a good thing that it was scrutinized before it even hit peer review. Found a pretty good writeup here:

https://statmodeling.stat.columbia.edu/2020/05/25/this-contr...
Any email id where should I send resume?
leetcode is the StackOverflow for interviews. If all you do is copy paste the problem, you end up with a bad interview process. If instead you use the problem as a base, understand what signals it is trying to test for, and change it to implement your specific needs, you have a much better shot of gauging the right skills.

Of course, that requires putting time into designing an interview pipeline full of things like rubrics, bias training, and sometimes realizing that leetcode questions don’t evaluate for the skills you need. Most companies aren’t willing to invest time into this and prefer to just copy <big co X> which is why you hear so many bad stories with what sounds like the exact same interviewers.
Are state-controlled media outlets really the problem? I feel like the issue is ads being purchased by groups tied to state actors (but not necessarily in any official capacity). Also, fake accounts posting misleading information (but not purchasing ads) is also a huge problem.
Domainer.services, the ultimate resource for domain name newbies
It's the hammer problem because management and IT have locked up all of the other tools, so you're damned right I'm gonna try to use the hammer.

Spooling up a docker image is low friction at a lot of places. Doing anything else can take an act of Congress.
And the social media security theater goes on and on
I'm not aware of any, but I don't think that until we're able to see proteins moving we'll actually be able to answer those questions visually. We've got a long way to go before that happens.
I've been out of the field for a few years, but I know that the graphics hardware (and accompanying software tools) make what you're describing much easier. This is best example I can come up with: https://jcheminf.biomedcentral.com/track/pdf/10.1186/1758-29... (see page 12)

Random asides:
1. once you're used to it, the simple isosurface mesh is super easy to work with (i.e. build molecules into), and for structural biologists the broad approximation is perfectly adequate
2. even so, the amount of unexplained blobs - some of which are definitely not noise - in my (xray) electron density maps was always both fascinating and frustrating. that's one reason why we don't spend much time on fancy renderings of experimental density at anything worse than subatomic resolution, because you're just sharpening the features that your atomic model doesn't explain.
Ah, yes, The Register.

Faced with the Great Satan of Software's apparent refusal to admit its mistake and eliminate the charge, AMD has made the fix available from its Web site free of charge.
Good ol Reddit Yes-sir-oo.
The Fed doesn’t do security selection. If the Fed isn’t equipped to analyze and select individuals securities. Additionally selecting individual names is a huge political concern. How do you decide which issues to buy? Personally I’d rathe the Fed buy market indices which are constructed By transparent and well understood processes instead of some opaque self brewed process. Plus the Fed is suppose to stabilize the market as a whole and provide overall liquidity to allow firms to raise money on their own. The Fed isn’t suppose to directly support individual corps.

Additionally it’s important to look at how the ETFs work. I believe the ETFs in question here are LQD and HYG for investment grade and high yield respectively. These ETFs track the iboxx indicies for IG and HY. Even if the Fed is buying BlackRocks ETF, this bolsters the prices of the individual bonds, which then moves indices higher, thereby also moving up other provider’s ETFs along with the entire fixed income market. Given this is the case, one should pick the most liquid ETF for each asset class (Ideally all ETFs should be purchased weighted by the NAV or trading volume of each ETF), in that case it would be BlackRocks for US fixed income.
It's not nearly the only answer, but at least in the case of Eric Garner, his arresting officers were all white. There were no black men or women arresting George Floyd either. I was tacking onto the long list of reforms that we should consider.
I use Dynadot and haven't had any issues.
As long as the people that did pay get theirs back.. that’s cool.
If it was average Joe's moving, sure. It's the cream of the crop though, the opportunity makers. It grows the economy where they go and shrinks it where they leave.
It's a fair question. eg, LSD dosage is in micrograms.

What I've recently heard is that sunlight and chlorine are very effective disinfectants. And that transmission is actually difficult vs eg measles. Someone can't just sneeze on you and you get it, typically. Close quarters for a longer period of time (15 min was the number I heard, don't know how that was evaluated) is required.

This does make sense if you think about known high transmission routes -- high density, extended contact, indoor situations.

So pools themselves are probably safe, including off-pool activity like the chair, the bar (to get a drink and leave), the bathroom, etc.

It's just what I heard from various sources. I don't have any citations to back it up. Best to do your own research. I only responded because I found your reply overly dismissive.
It is 100% for making money by gaming the current systems.
Perhaps one day something good comes out of it. For example: Formula 1 racing is also totally not necessary, but can bring nice innovations for the 'normal' automotive industry.
If you want a detailed technical view of what the Fed is doing I highly recommend Nathan Tankus' blog. Though I don't think he's specifically covered Blackrock's role.

https://nathantankus.substack.com/

I'd start with the series "The Federal Reserve's Coronavirus Crisis Actions, Explained"

https://nathantankus.substack.com/p/the-federal-reserves-cor...
HFT has significantly lowered trading costs for all investors. Here's a statement from the CEO of Vanguard espousing this position:

https://www.cnbc.com/2014/04/25/vanguard-chief-defends-high-...

Because of automation, the amount of resources used for trading have actually decreased. Computers are a lot cheaper that the many many humans who used to be involved in the process.
Well, but static articles shouldn't need a web framework in the first place.
Unemployment doesn't work like that. As long as you've paid something in, you can get paid out the same as anyone else. So you could have a situation where non-immigrants are paying into the system more than they get out, while immigrants are getting paid more than they paid in.
[Ask HN]: Poll: Do you believe there is nepotism at your company?
For what it’s worth, I would much rather my city get nuclear bombed than my city have to go through what Nanking went through at the hands of the Japanese Army.

https://en.m.wikipedia.org/wiki/Nanjing_Massacre
Okay, I know how docker can mean containers, and I agree that Dockerfiles are quite similar to makefiles, but how does docker relate to source control?
> old Microsoft of the 90s

Not to jackknife the thread, but most developers were born in the 90s and do not remember this Microsoft.

The engineering and dev managers DO remember this Microsoft. So while I agree somewhat they are trying to repair their image, with the younger crowd they only know MS as Minecraft, VS Code, Azure, Github. More people probably got exposure to Linux via WSL than all of the previous installs combined.

90s me would have thought hell would have frozen over, and now me knows it has.
I encountered it at my two previous employers (including one FANG). At my current place, I made a point to ask about their diversity initiatives and hiring practices during my own interview, because as a senior engineer I am interviewing 20-40 people annually. I’ve had no pressure to push a diversity agenda at the interview level.
"The default way a Java/C# dev would probably approach this is to create a class"

No, not for a long time. The idiomatic C# way would be to use LINQ which actually predates Clojure a tiny bit. Java (since version 8 in 2014) could use Streams to similar effects. Either way the solution would be as short as your example.
Indeed, it doesn't help post exposure. UMN is doing two other trials, one for pre exposure and one for treatment. IIRC, all of them do not use zinc or macrolides. (Some patients of the post exposure prophylaxis trial used zinc, but there's no statistical difference without, although the authors warn about confounding factors).

Some important limitations of the study, results notwithstanding:

- There were basically no PCR-confirmed tests, due to lack of testing materials, and patients reported symptoms themselves

- The whole thing (reporting) was done via email or telephone, no in person checks (even HCQ or placebo was shipped to the participants)

David Boulware (the study's PI) on Twitter, a couple of weeks ago, complained that he sought funding from the NIH for this trial, but he got none.

I thought it was all said and done for post exposure prophylaxis, but at least NEJM's editor is not of the same opinion, and mentions that even in this field of application there are still unknowns[1].

There are larger trials going on, like UK's RECOVERY, which will likely give firmer answers.

[1] https://www.nejm.org/doi/full/10.1056/NEJMe2020388
> I would always move my whole hand and hit backspace with my right ring finger.

My understanding is that (maybe non-intuitively) whole hand movements are more likely to cause wrist-related RSI than single finger travels. (Single finger travels are more likely to create knuckle RSIs, certainly.) The missing letter in RSI is sometimes "movement" as it is stress from repetitive movements.

Anecdotally, the biggest mistake and the source of most of my pain from the way I had learned QWERTY was a lot of whole hand movements, and reducing those was a very clear and specific goal for me when I relearned touch typing (on Colemak).
> Can citizens buy riot shields?

Materials supply is scarce right now due to covid -- all the plastic sheeting gone to face masks, barriers in grocery stores, etc.

http://www.yeoldegaffers.com/project_shieldpress.asp
Ah, but comrade, paying rent itself is inherently unfair. It allows for profit off merely having bought something sooner than another had a chance to. If the rent stops now, why should the rent start back up?
Yes, a crystallized protein will always be in a single conformation, or you won't be able to see it because the electron density map will be an average of all possible conformations, and therefore meaningless.

Single particle gives you the opportunity to see different conformations, but only if the data is discrete. If there's a continuous amount of conformations (think a molecular motor that's rotating) you would need nearly infinite data to resolve a nearly infinite number of conformations. If the data is less than continuous, you can image enough particles to see all the different conformations by constructing multiple models in parallel and using 3D angular searching to bin them by what conformation they are in. This is a computationally exhausting process, however.
I guess it depends on your underlying viewpoint towards markets and capitalism.

I certainly don't think liquid financial markets and efficient asset prices qualify as "contributing nothing to society". Those components are extremely critical to the efficient allocation of investment capital, and overall functioning of the broader economy.

But if you're generally skeptical of markets and capitalism then you may not agree. However I'd say that should have a lot bigger fish to fry than the $2 billion HFT industry. For example the $300 billion advertising industry, or the $100 billion accounting industry, or the $100 billion credit card industry.
Does this include Fox?
> algorithms for plasma control and diagnostics which take advantage of new hardware (GPUs)

I don't know about that. Here's a few bullet points from [1] (which someone else linked to in this thread; it describes the approach taken by these guys at TAE) that don't inspire a whole lot of confidence:

"Our prior is “reasonable”, but is it really the marginal distribution over all possible plasmas? hahahahhahahaha. We model many effects, but plasmas are complex beasts and we do not model all. We only have one measurement, of much smaller dimension than our unknowns. We never sample from the tails. takes too long to get samples. by definition you can’t really validate them. Will we ever know we’re right about anything? we have zero golden data"

[1] http://hyperion.usc.edu/UQ-SummerSchool/pres/Langmore.pdf
Except sadly I think they actually are.
It's not the same set of members, there has been many generations of Bourbaki.

They're pretty far from dead, they just published a textbook in 2016 on Algebraic Topology.
The police have frankly earned every last scintillia of their hatred from their actions and lack of accountability.

We don't accept a rapist or fraudster blaming society for the damage they do to get the sex or money they want and we should certainly hold actual authorities to higher standards instead of lower ones. The system being messed up does not negate their own moral agency and deriliction from it. To acquit them is even worse than even "just following orders" but an utterly insane "it is unfair that I am being judged by the intentions and outcomes of my actions taken on my own initiative".
Good point. I will definitely change that part.
"Well these novels all look fine, Mr. Stephen King, but you see there are just so many fakers out there and even though you can talk very well about the process of writing a book in a way that only someone who either actually did know how to write or who was so wonderfully skilled at faking it that they'd be able to make more money applying that skill directly to a job that called for it (have you met our CEO, incidentally?), but oh my, yes, there are so many fakers, yes I'm sure there are a lot, it must be that our bad hires have been fakers who tricked us and not that environment, process, team, and management quality significantly affect people's performance in various ways and that we're badly deficient in some of those areas—anyway, point is, next we're going to quiz you on obscure citation format details across three different citation styles, have you sentence-diagram and label all the parts of speech of every word in the first chapter of Moby Dick (should only take you 5 minutes or we'll start obviously betraying that we think you're an idiot), and then write out for us the subjunctive mood conjugation of a few irregular French verbs."

"Uh, will I be doing much of that on the job?"

"Oh god no. Where do you think you are? This is Buzzfeed. You'll be hammering together barely-coherent prose that's just shy of stolen and publishing it as fast as possible."

^ your average programming interview with whiteboard grilling.
I'll have to do some reading, I see (the pragmatists are as recent as I've been, so that should help).

In the meantime (unless you'd care to do a tl;dr of postmodernism for us?), I'll leave these two links here, neither of which are probably edifying, but hopefully one may be amusing:
https://existentialcomics.com/comic/344
https://www.youtube.com/watch?v=57PWqFowq-4
The first X was in quotes, so it was a purely lexical reference to the words themselves, without referring to any conventional meaning that those words might have. The second X was unquoted and so by that I meant to convey the usual meaning in English.

Another way of saying it would have been: erm right but experience of Javascript is not experience of Clojure, regardless of any influence Clojure may have had on modern Javascript.
You are gravely mistaken if you think news stations slant "far left".
Done! Changed from "macOS in a Docker Container".
Very nice, what features are you looking to add next?
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For one, when it says "the taxpayers will be eating the losses".. it raises some flags for me. Might just be hyperbole, but it also suggests a possible misunderstanding of the fundamentals of how the Fed operates.
I have a hard time believing he would have been unfamiliar with Plan 9. It wasn’t exactly obscure in the research community at the time. See the USENIX proceedings in the late 80s and 90s.

This is mere speculation, but I doubt he would have appreciated Plan 9.
Thanks--will look later. For someone who already has, are these mostly legit? That is, is there enough context to see that the protesters were acting lawfully and not the instigators?
Ethereum has been moving to PoS soon for a couple years.

It's still the intent, but PoS is effectively still unsolved. It's not just "can it decide blocks", it needs to have the right balance of incentives to be self-sustaining, or it destroys itself.
Same. I had some taken at a local store, and thought they came out terribly. Not worth the money at all. Set up my DSLR in the kitchen on a tripod, digitally placed 2 right-sized copies on a 4x6, and printed them at the drugstore for less than a quarter. I used decent equipment, but a modern phone these days will take an acceptable photo. (In fact, I just searched the iOS App Store at there’s at least a few apps that claim to make acceptable photos.)
Sure, you go through one of the automated gates, pretty common in most European airports now.

Face recognition gives the green light, since (part of) the picture is a perfect match.

A human may not be fooled, automated face recognition may.