skysight-inc/HackerNews huggingface dataset:
Nature thwarts gene drives by modifying their targets, so it's important that whatever is being targeted can't easily change. Surviving instead of being killed off is certainly an evolutionary advantage, after all :-)

There's been some research on finding targets that can't be mutated. Here's one example: https://www.nature.com/articles/nbt.4245
One of the notes included a base64 encoded message that reads:

"You are Big Brain. Good job finding an Easter egg. Know that God is Real. Believe in Jesus Christ and repent for your sins. It's not just a bunch of rules you have to follow but a relationship with him. Know that everything happens for a reason and God only wants the best for you."
Zoom plans to charge users to access encrypted service
Are technical fields really an edge case?

I suspect going to a university is helpful in most STEM related fields. In anything medical or law related you don't even have to think about getting a job without a degree. I don't see how anyone can compensate an economical or business study by doing project on their own.

If anything I think IT is an outlier, because not going to university and learning the subjects you would have been taught on your own might be a valid option.
All Shopify shops can now accept Bitcoin
It doesn't suck. It has nearly all features you could possibly need, and then some. People who expect GIMP to be identical to Photoshop suck.
I fell in love with Electronics at 16 precisely because of these kind of books that 60's printed full of them. I discovered them in my father's book collection in early 90's and these were my "drug gateway" to my programming career.

Having electronics and hardware background made my programming so much easier as it was easier to understand some concepts and choices that to "pure software" engineers appeared weird.

These days I love to combine hardware and software integration and boy oh boy, it pays so much better. Not many programmers out there that will offer a bill acceptor and/or magnetic card reader integration for a POS solution when your local restaurant wants to modernize their shop.

Show these kind of books to your kids, you'll never know where the rabbit jumps from.
The difference between an art grant and a tax credit (which Marvel/Disney have got plenty of) doesn't feel especially material to me at that scale. The resulting artwork is also accessible to everyone.
Fonterra, New Zealand's largest company runs along these lines. It's a dairy company, so basically gets milk from dairy farmers and puts it on the market. It is a co-op owned by those farmers.
wow, we're really gonna defend the indefensible in this thread, aren't we?
At the moment remote jobs are very competitive, you're likely running up against local competition within the US especially given all the layoffs there...
I'm unsure of why you say "almost" everything when the UI code is simply calling the python API to do it's function. You could do anything and _more_ in the python API, as it's what the UI uses but you can use all the parameters via the code while the UI doesn't expose everything.

Unless something changed recently regarding this.

Also, regarding executing the code from outside, you can run blender headlessly, running the code with it when running blender via terminal. So you could use it as a windowless client if you so wish.
n=1 obviously

I take a multivitamin with 15mg zinc in it, as far as I can tell none of the autism specific symptoms are affected. The biggest difference is that I feel sleepy in the afternoons when I take zinc, when I don't take it I feel more awake but less rested.
No, you did not see rhetoric accusing heterosexuals as a class of being prone to promiscuous behavior. Unfortunately, even in 2020, it seems to be necessary to spend paragraphs and paragraphs explaining what homophobia is until people get it. Here is an article from 1987 that does some of the work:

https://www.latimes.com/archives/la-xpm-1987-07-20-me-2954-s...
Who Dares to Rent a Dress Now? Coronavirus Upends the Sharing Economy
Zynga to Buy Peak for $1.8B in Its Largest Deal Ever
> Having debt in your capital structure indefinitely is a perfectly fine decision to make.

We're hearing this argument a lot recently, but aren't we past that already in 1980s?

As I recall, it was somewhat popular among companies to pile up leverages by buying a large potion of their own stocks. The reasoning was the same as today: it was supposed to benefit shareholders because a levereged BS has tax benefits.

... which subsequently resulted in those highly-levereged ("recap'ed") companies filing for bunkruptcy. So that hack was shunned by the time of 1990s. What does make this time different?
Well let's pretend I don't have a field and I'm just about to go to uni because someone on the internet said I should go there to learn the important stuff.
I was born in post-communist country to the familly of blue collar workers, where nobody around me didn't even finished high school (fun fact, those more distant family members who actually had university degree or even hold profesorship position spent many years mining for uranus in political prison and then decades sweeping streets).

Anyway, I already had fulltime position working as software developer since the age of 17 (it was a bit of necessity, but I also like it very much) and after finishing my highschool diploma I decided to not apply and continue working.

I went to study CS at the age of 23, while still working fulltime. Being a bit older and more experienced, but also time constrained changed my perspective a bit. I was in there just to get knowledge that I decided are relevant for me, there was close to zero time to be spent on social time or taking some filler classes that might be interesting.

I spent three years in university, taking all the classes that sound interesting to me in areas of math, compilers, machine learning and computational logic. At that point I depleted the pool for both bachelor and masters classes and for the rest of the time I would have to go through fillers and decided to quit without graduating.

I am glad about both of my choices: both having break between high school and university and quiting early. I feel like spending time in university is very valuable for both professional and personal growth and everybody should probably took it if they can afford it, but I don't think that this is your only valid choice.

It should be ok to spend few years wandering around to find what you want to do with your life instead of spending rest of your life paying for debt you acquired just because you can't see any other viable path.
What do you mean you have no evidence? I thought they said this directly to you?
I do not understand your argument. Today there are still competitions of gameboy games (and many other consoles) that have been emulated to death, where all the glitches and cheats are well-known, and there are hundreds of "mods". You can still participate in the "no-cheat" category, which is one of the most popular.

The fact that people can cheat, does not force you to cheat when playing. This is exactly the same thing in sports.
Thank you for using PaperCSS! It’s always a lot of fun seeing it used in projects out in the wild :)
Understanding MITRE’s 2020 ATT&CK Evaluation
Perhaps faster than other framework implementations but there is no way it’s faster than the standard DOM methods.

https://stackoverflow.com/questions/21109361/why-is-reacts-c...
I think apart of what has been already said, it depends on the kind of person you are.
I see people with and without a degree in CS that thrive and some that do the opposite.
Personally, I have been working as a software developer for the last five years. And during that time I have had a couple of phases were I suffered from some kind of imposter syndrome. I have a master degree in International Business and hence lacked some fundamental CS skills (e.g. Algos, Compilers, Operating Systems).
So during the last few years I worked my ass off to learn all this stuff, because every time I read something about software engineering and it mentioned any of these things I felt less value because I knew I don't have a CS degree. I also felt intimidated by some of these topics. So, I sat down and learnt all the stuff I thought I needed to know in order to feel better.
Now, after going through this period of studying in order to get rid of this stupid imposter syndrome, I feel kind of burnt out. It's funny, because I finally have the self-confidence I was looking for during the last five years, yet I kind of lost the creativity and motivation that I need in order to enjoy what I'm doing.

So, I can only recommend to find out what kind of person you are. But tbh, even though I got a degree that is unrelated to CS, I'm glad I went to university. I would had been a very different person without that experience. And in the end of the day, you will have to work for a veeeery long time (well, at least that is the reality for the most of us). So, what are 3-5 years spent doing something that gives you the opportunity to experience stuff you won't be able to find at work (well, except for the sunk cost, but I reject to think about education in this way)?
> The trolley problems invalidate the principle because of the unlikely certainty that they assume.

We're living the trolley problem problem in real life, right now, because human beings are bad at estimating risk. A lot of people are operating with a certainty that IF you are EXPOSED to the virus, you WILL contract it, and it WILL be terrible, and PROBABLY fatal. Therefore, no amount of safekeeping -- masks, distancing, wiping down delivered groceries, baking mail and newspapers -- can be too aggressive. For such people, diverting the "trolley" to make long-running, terrible financial hardships for a third of the population is an easy call, when they feel they are literally saving the life of everyone on forward track.
Perennial reminder of a conversation early on in Facebook's life:

> Zuck: Yeah so if you ever need info about anyone at Harvard

> Zuck: Just ask.

> Zuck: I have over 4,000 emails, pictures, addresses, SNS

> [Redacted Friend's Name]: What? How'd you manage that one?

> Zuck: People just submitted it.

> Zuck: I don't know why.

> Zuck: They "trust me"

> Zuck: Dumb fucks.
Ask HN: Can you discuss CS in your native language?
Yesterday I needed to message my CS teacher about an exam question, and discovered that I was unable to formulate my question in Swedish, so I opted to write the whole message in English instead. I don't want to share the message, since it is related to an exam, but it was about Iacono's working set structure.

Have your native languages incorporated CS terms to any usable level, or do you have to switch to English, in part or wholly, when the topic is discussed?
You have just described the British and Japanese police. They police just fine from the crime rates.
Show HN: FontEdit – A desktop app to develop fonts for embedded systems displays
If you seek an "improvement in society", you might try reading more carefully. My comment was obviously making fun of the "deranged": to whit, people crazy enough to like screwworms. I have no opinions of the current president that don't extend to any other politician. They all like war, so I don't like any of them.

Have a nice day.
Sustainable production of value-added carbon nanomaterial from biomass pyrolysis
MPWTest Only Tests Frameworks
"in the USA".
It just never does. Just as in the parallel universe with personal airplanes powered by sodium batteries, Lithium-ion and four-wheeled cars never made it to the mainstream. Incumbent power.
UK: Government unlocks £150M from dormant accounts for coronavirus reponse
How so? That article is arguing for what they think the US should do and it basically matches what the US did in fact do. The CARES act was by far a bailout to citizens directly through the stimulus checks and the extra $600 a week in unemployment and indirectly by funding payroll for airlines and small businesses. The rest is basically loans which have to be payed back and funding for hospitals and state governments.
With camps, sports and lessons cancelled, kids are going free-range again
Yeah sorry I think my grammar wasn't perfect there. What I meant was there are a lot of other cases of police brutality in which nobody is help accountable in that individual case.

I agree with you completely that the rioter behaviour is appalling. I feel like I have seen just as bad as the things on this site from rioters and it deeply saddens me. I am confident however that those rioters that do stoop to the ultimate lows including attacking store owners will be punished to the full extent of the law.
I prefer to use it as a rendering library only. That part is good. But much of the ecosystem is a mess. CRA, a fundamental piece, is a trainwreck. If you eject you can see how much focus on local simplicity has been implemented at the expense of global stability...
Ooof. I've done .net dev in the past, but most of my stuff is not in that space anymore. Are these the mono people working on this?
> an account is ‘dormant’ at a particular time if the account has been open throughout the period of 15 years ending at that time, but during that period no transactions have been carried out in relation to the account by or on the instructions of the holder of the account.
The cynic in me thinks the website won't self destruct, but instead will stop working because the domain isn't renewed or the server isn't responding.
I really like your idea and I felt like leaving a comment on your website! But I have a question: what does the heart button below other people's comment?
Of course it matters. There is far more probability that you will be attacked than you have of falling. This is just basic math. Let alone the source of the danger, one of them is far more traumatic.

Let's say you get hurt falling off a tree. You wont suffer violence.

You ever been in a fight? Ever? This is a real question. Answer it please.
There are few other issues with how websites implemented it. For example, at work, appleid or few apple domains are banned (they wanted to ban iTunes streaming etc.) when I tried to login into Pocket (Read It Later) [Web Version], due to this blocking, the whole login form get hidden once page load complete, and I cannot even login with my username and password.
A Nix terminology primer by a newcomer
This is related to seniority. When your carreer proves your worth and your wits, people stop asking at what age you started speaking, at what age you stopped pooping your pants, when you learned to read and write, what your SAT scores are (or whatever the equivalent is at your country) and finally which college you went to. Then they stop asking (but are still impressed by) the places you worked at, the projects you worked at and they finally let you off the hook when there is nothing else to prove.
Ask HN: Side Project Advice
I'm currently a full-time dev in the UK, on PAYE but I want to start monetising my side project, but the swamp of HMRC paperwork has got me down, does anyone know of a 'quick and easy' UK-based guide to staying employed but having a second income from a side-project and how to deal with the accounting/tax?
You shouldn't rely on only ed25519 for DKIM, always double-sign your email with RSA as a fallback

The problem with email will forever be that there are so many badly configured email servers out there. Any new standard in email will always need a backwards compatibility ad infinitum.

In your case I'd recommend moving your DNS to another DNS provider. Just pick any and go with that.
The federal government is giving unemployed people 600 per week (31,200 a year) on top of state benefits regardless of their income so anyone making less than that is making more on the federal government alone. That is why total income has gone up.
Some Android phones can be soft-bricked using this picture as a wallpaper
How to run a remote retrospective with Trello
I’m guessing that Title Case in English is a logical extension of the European norm of capitalizing proper nouns; a title is the proper noun used to identify a written work.
Ask HN: Where is your #1 happy place, why and why not just move there?
Where? Tanigawadake Raspberry Youth Hostel. In the mountain valley town of Minakami, Gunma province, Japan you'll find a strikingly orange building. It has an epic view of Mount Tanigawa (nicknamed "The Mountain of Death"), the rest of the mountain range and a small river. It's ~2h north from Tokyo on mostly shinkansen.

Why? The views, the air but mostly the people. The man (Masatoshi-san) that runs it has an inspirational story where he quit his 8-to-midnight job in Tokyo and bought the hostel after a hike in the valley. He moved his family there and now he gives (free) daily tours of the region to every single person that visits driving them to all his "secret places". The food at the small restaurants around is fantastic and it's within easy driving distance to 10+ onsens (hot springs) including Takaragawa Onsen, one of the premier ones in Japan despite its remoteness. Over the years, I've met many people in that valley that just work remotely and have their kids go to the fantastic Buddhist mountain school nearby.

Why not move there? Visiting Japan is easy. Living in Japan seems daunting from a logistics, culture and language perspective. I live between Montreal and LA now.
... but don't we charge our phones every day? 1000 cycles feels like a minimum for that - would be required for a phone to last 3 years.
It seems, but it's not true. There is no well defined organization or any other structure behind these protests, no funding and no force. Revolution is always about army, and I don't think U.S. army will go against U.S. police or at least stay neutral.

From another side, in my country, when a few people were hurt (but not killed) by police, during police operation, it ended with months of protests. And also, I hardly understand U.S. people at all. If a police officer in my country would stand on a person's neck, in public, I am absolutely sure people would start shouting at him, throwing stones and so similar things up to pulling him off that person in direct physical confrontation.

Don;t get me wrong, we respect police. But we are not afraid of police. They serve us, we are not their cattle. From perspective of my culture, which I'm not stating is the best, U.S. people with all their amendments look like voiceless lambs. Police officer drives into crowd and crowd lets that car through. They do not break glass, do not cut tires, do not pull that officer off the car to describe with expressive gestures how upset they are by his actions.
If somebody takes a life for an unjust reason they should be punished however the law defines the punishment. Whether you're police or not, nobody is above the law.
The science behind the SpaceX astronaut launch
Over 10 agonizing days, this worker walked and hitchhiked 1,250 miles home
Yes, that is indeed a problem.

However, CEO and shareholders are playing a repeated game here. So they can retro-actively reward last years performance by giving more (or less) money for next year.

Mostly, shareholders do want CEOs to take some amount of risk. And giving your CEO eg stock options means you want to encourage risk taking.

If you want your CEO to be careful, you pay them in eg long term company debt instead.

Exactly how you align the precise risk appetites is a harder problem. And there might be some loopholes clever management can exploit. But the broad strokes are clear.
The Future of Higher Education Will Be the Same, but Worse
Amateur footballer who woke from a coma speaking fluent French
The problem is that there's nothing inherent about a hypothetical that elides irrelevant details, it elides only whatever the author of the hypothetical wants to elide. Hypotheticals can let us agree on one aspect of a situation, but it can't make us agree on how relevant that aspect is to the situation we're actually interested in. This is why the trolley problem as applied to autonomous driving is so problematic, whilst it's an interesting thought experiment, its totally irrelevant to the person actually designing a self-driving car. It's a perfectly valid position to take that a situation is complex enough that hypotheticals aren't ever going to be helpful in reasoning about it.
Nothing new ... that has been a standard statement made by the military at every CCP session i.r.o Taiwanese independence.
America’s inequalities burst into the open [via FT]
Connor and Victor – Best Treasure Action Game
The goal of this game is find the hidden treasures while avoiding the police officers. Once all the cash is retrieved, you must escape to advance to the next level!
https://github.com/ryansolid/dom-expressions/tree/master/pac...

Looks great!
I would add political to the number of topics that are difficult to discuss. Sitting in Africa, the issue of colonialism is one such topic. That colonialism was bad is something we all agree on. Trouble comes on how much blame of our current problems are due to colonialism or due to current corruption. It is such an emotive topic that typically pits the all our problems are due to colonialism against the all our problems are due to corrupt politicians. Good luck convincing either side that the answer lies somewhere in the middle.
That's good on EHI. Though perhaps that planning would have cost some extra time and money that would have been 'wasted', if the pandemic hadn't happened.
Personally I find touch typing numbers a lot slower. ubernete is as quick to type than a stretch to the 8 key
With the exception of some of the rules under the Hardware section, this is some great succinct advice on software development in general :)
Facebook has information as a business model.

It could be improved, like the user having the real ownership of all personal data and with confirmation to where, to whom and when delivering it.

But, for real, will those changes please their investors?
Yes. Hence the 'broadly'.

As an investor, you can also always just add leverage to your index fund holding, if you want more risk. If your jurisdiction allows you, that is.
Easier Troubleshooting, Greater Insights for Distributed Databases
Keyword and Definitions Extract from Text – NLP
> Not to imply you're not ready, but in response to "I've been coding since I was young, so I'm not worried about struggling academically"

To add to this, I thought the same would apply to me when I went to uni. And it did, until about half way through second year. Then I discovered that the classes were passing the boundaries of what I'd self taught myself, and I had a big rush to catch up.
You were talking about stop and frisk opposed to racial profiling more specifically. So I looked that up and it looks like Texas has already achieved transparency on that matter: https://www.tcole.texas.gov/content/racial-profiling-reports

Transparency is the only way to root out actual and suspected corruption. It’s not a cure but a required prerequisite.
I would like this site to ultimately aid with that end goal. A website however cannot send somebody to jail for a crime that they have committed. It can however hold information and inform people about crimes that may of been committed.