skysight-inc/HackerNews huggingface dataset:
But that way you'd be avoiding the results completely(even in the unlikely event that they could be potentially helpful)
While true (I make a living working with them), I don't think the OP is that interested in graphs which are that small. What makes molecular graphs a bit more challenging is that there are 1 billion or so "small" graphs to search in a very large database. There are also important issues in how to represent a molecule as a molecular graph. Concepts like stereochemistry are tricky to handle.

"Search" here means subgraph isomorphism search.

No one that I know of uses a graph isomorphism test to compare two structures. Instead, they convert the molecular graph into a string, where the atoms and bonds are in a canonical order - perhaps a SMILES string or InChI string - and use a string search. Graph canonicalization is therefore important for molecular search, but not for the "complicated graphs, say social networks" the OP mentioned.

One specialized topic I worked on was the maximum common substructure problem. Given two molecules, what is the largest subgraph. Now extend that to N molecules. Now, find the largest subgraph which is in at least P% of those molecules.
x-files theme intensifies
It should be noted that AMD has SMT, which is pretty much the same thing.

https://en.m.wikipedia.org/wiki/Zen_(microarchitecture)
It was “the” RSS reader. Nostalgia probably.
There is no fully "green" power, but almost everything is better than climate change.
You should be able to get through with basic high-school chemisty.
You need to know there are elements C, H, N, O, P, Ca, K, S, know what an ionic bond and covalent bonds is and be able to look at the structure of a molecule.
The need to thing sexual thoughts
Upon conception it was neither "intended" nor "likely" "to be understood by only a small number of people with a specialized knowledge or interest" and it is still not intended that way nor likely, that only few people _can_ understand it. It is just that people choose not to take time and understand it.

I don't agree with the conclusion you draw from a definition of esoteric, that is without context anyway, taken from a natural language dictionary.
Essential Tool for Every Developer
As a longtime Hong Kong resident, the worst part about this for me is the abject intellectual dishonesty - we already know that this is the real[1] beginning of the end of Hong Kong's autonomy, so they could at least have the decency to be straight with us.

CY Leung (the previous Chief Executive) said[2] the quiet part out loud yesterday:

> "Former Chief Executive CY Leung acknowledged on Sunday that Hong Kong’s annual June 4 candlelight vigil could be banned, along with the group that has organised the event for the past three decades, under a new national security law for the SAR to be drawn up by Beijing."

Putting that kind of censorship on the table is antithetical to the spirit of OC2S and the foundations that make Hong Kong great.

1. The Causeway Bay booksellers were a foreshock.

2. https://news.rthk.hk/rthk/en/component/k2/1528043-20200524.h...
LOL. Nothing I’ve seen so far about Artificial Intelligence is intelligent at all.

And anyone that tells you that A.I. is intelligent, might as well be selling you some snake oil.
The author counts years from the founding of Rome (ab urbe condita or AUC), so subtract 753 to get the AD year.

Or: yes, this is a recent blog post.
Possible.

Also possible I am worth more as now I am not restricted to the employment options within ~1 hour of where I live. For example to companies willing and able to pay more.

I found I was the latter which was one of the reasons I decided to go all in on working remotely.
L-1 visas are the ones used in the sleazy "train your offshore replacement worker or lose your severance" kind of deals. The replacement comes into the US on a L-1 visa for a few months to get trained, then returns to India.
I'll grant that the three are better than Slack alone. I guess.

But Jira is not good. Likewise Confluence is not good. It's more like bleeding out slowly rather than all at once.

What would be better? I don't always love GitHub, for example, but it hits these use cases in a far more effective and productive way.
I am thinking about more customization, especially this that allows the user to 1. suppress (like now) or 2. remove the results entirely. But in my defence, it was a weekend project for a noob like me.
>> your spouse cannot work.

> I think that has not been true in a while.

It is temporarily not true (since an Obama Administration rule change in 2015), but the change is being fought in court (the case was remanded a few months ago from a panel of the DC appeals court back to a lower federal court, after they found the plaintiffs to have standing; I’m not sure what the current status is).

The Trump Administration has stated multiple times that it intends to roll the rule back. I’m not sure what the status of that is either; it’s not clear if they were just too disorganized to get around to it in 3 years, or if their stated intentions were political posturing and they never intended to follow up, or if they changed their mind, or ...

The people affected have been able to work for a few years but I’m sure the possibility of losing that right on short notice still causes some stress.

I’m not an expert but if you are curious about the details the keyword is “H-4 EAD”.
One of the creators of Party Down was Rob Thomas, the guy behind Veronica Mars.
Have a free tool for devs and digital designers? Submit here. Is free
There’s a similar organised crime thing in Sweden. It’s not uncommon to see some homeless person being berated by someone of the same race in a high end luxury car that has been modified.

The nature of the argument does imply that they know each other.
Shameless plug: A bit old blog post from my company on the same topic. A bit more mobile app-specific. A little old but most of it is still relevant: https://mobisoftinfotech.com/resources/blog/top-34-technique...
I made something similar as a toy project after being frustrated with Synergy/Barriers poor support for my keyboard layout (Czech).

It's for Linux only as it relies on udev and the encryption (AES with a key derived from a password shared between clients and server) is not ideal, but it was a fun project for sure.

https://github.com/htrefil/kshare
Why Edge is the future of desktop apps
The best way to combat outsourcers and other bottom-feeders is to give priority based on salary (and enforce this by cross-referencing with the IRS).

This would also kill the financial incentive to hire H1-Bs for low pay.
We can get electricity from any kind of dam except one that blocks all water forever. We get electricity when water flows through, see?

The best kind of dam from the point of view of the power utility is one that allows the water flow to scale freely from zero to overwhelming to match electricity demand, and never allows water to bypass the turbines. But that's an extreme, not the only kind that makes financial sense. If you both reduce the time flexibility and also allow some water to bypass the turbines, you can usually get most of the power at a small environmental cost... usually, not always.
Talinn, Malmo Sweden, Coventry UK.

I lived in London for 6y and it’s comparable.
However, they do push hard for H1-B visas.
> The EU warranty and 'remote purchase' laws [...] are quite excellent

There is a large difference between buying as a consumer and business/freelancer, though. If the laptop is outright terrible, but not technically _broken_, then there's not much you can do but eat the cost. Even selling it on eBay becomes complicated because now you have to follow EU law if a consumer buys it.

Written on a MacBook that I wish I could have returned...
Not an expert, but I think this qualifies.

Government policy to improve energy efficiency (government grants to improve factory production efficiency) can lead to increase in total energy use as the factory is more profitable with better efficiency.

EU does have programs to improve efficiency in this manner.
obnoxious
90% Referees of La Liga Support Real Madrid
Properties of Lens Color in Sunglasses
I'm not questioning that some restaurants do it. I’m not sure how it can be cheaper for a single-address restaurant to do it, compared to a pooled service. If half of your workforce is just driving back, that can’t be efficient.
what is COL?
I'll take this into account too towards my attempt in making it more customizable.
I'm comparing the whole cities. Shoreditch is lovely in my opinion, used to go there every week end.
JEP 383: Foreign-Memory Access API (2nd Incubator) – Targeted for JDK 15
> You still need people who understand things like docker, kubernetes, endless different database options, sharding, indexing, failover, backup, message queues, etc.

Large companies at significant scale need to know these things. Smaller companies don't need kubernetes, message queues, or anything beyond a simple standard off-the-shelf setup. I'm guessing the author was referring more to small/mid-sized companies that aren't at FAANG-scale and have no need for that complexity.
20 Minute Meetings
Good points. Not saying there isn’t an upside to remote work, but there are downsides as well, which in the long run, may overshadow the benefits. It’s much harder to build camaraderie in a Hangout or Zoom than in frequent, random, physical interactions with people. There’s also a biological component to bonding (pheromones, touch, oxytocin, body language, etc.) that simply won’t exist in a virtual environment.

I’d also point out, you’re enjoying the luxury of those freedoms (privacy, non-creepy norms) because labor power still exists and you can easily move to a different company or whatever. But fast forward 10 years, everyone is remote, labor pool is much larger, norms of monitoring and policing communication are established, then things start clamping down across the board as standard practice.
The Terminal (2014)
Yeah the latest season is on Foxtel in .au
He knows China is powerful enough to do this without meaningful consequences. Taiwan not yet, but soon.
Huawei Releases “CableFree” – 5g antenna technology. Increased coverage
These vulnerabilities feel like Coronavirus. They sound scary but has practically little threat, but we all pay dearly for the mitigation.
Where do you get so much self righteousness to conclude that your assessment is appropriate for all companies, all positions, everywhere?

And why does there have to even be a single "formula" for work in any case? I find that attitude extremely narrow minded.

At the same time I fully support your freedom to seek out the opportunities that work for you. I just don't understand the attitude that other people must be on power trips if they don't think they way you do in this regard.
+1 for Kerala.
My native is Kerala, but I was living in Bangalore for job. Due to Covid19, right now I am WFH from Kerala. Only issue I see is, in summer 3 months (March to May), it will be hot and humid here, so AC is required. Otherwise all good.
So, back to ASCII bbs browsing? Because any JS, weird Unicode, or media parsing is a potential occasion for untrusted cose execution
How does lockdown affect yacht crew members?
No one accepts "It's not x, it's y" as correct. Well, maybe some illiterate Philistines do. But no one really thinks that's correct.

You have to put a semicolon in place of the comma or it is just plain wrong.
It is not just about degradation during transport. The samples need to be taken from deep in the throat and high up in the nasal cavity. This hurts quite badly. If the sample is taken from too low the chance on a false negative result are quite significant.
I am not doubting that Lisp is a language with which can be used to write succesful commercial applications. I am questioning the claim that it is vastly more productive for commercial applications.
Of course it is not really possible to say how somebody else in a different language would have needed, so maybe a compromise would be to see some 'magical'lisp code examples.
If he's already working remotely, then presumably he was already competing with the worldwide applicant pool.
Signal patches (minor) approximate location disclosure flaw
Multiple music streaming services with the same content seem to be able to exist in some sort of equilibrium.
Am I the only one having a very, very hard time parsing much on threat modeling out of this article?

Wikipedia seems to confirm my understanding as to what threat modeling is: "Threat modeling is a process by which potential threats, such as structural vulnerabilities or the absence of appropriate safeguards, can be identified, enumerated, and mitigations can be prioritized."

There's a little bit in the article about mapping your system, and maybe at looking at interfaces and interaction points? Don't see anything about attack vectors, modes of detection and response, etc.

Also, why only the look at digital security? Being aware of how your systems interact with the physical environment can have a strong influence in how you approach architecture, even if the answer boils down to "our infrastructure team handles that".
Orion tweak from Packix repo restores iOS 12 3d-touch gestures for keyboard (hard-press anywhere to move cursor around, press even harder to select text). This, with RealKeys (adds haptic feedback to the keyboard) are the only tweaks I use, and they are truly a game changer when it comes to typing.
You could be right on the economics and still wrong on the motivation. Are the economics so clear cut in every context that an uncharitable explanation is necessary?
If you want to dig into the differences more, I highly recommend the book Designing Data Intensive Applications. Analytics systems have different requirements from normal transaction processing systems, so it naturally follows that DuckDB could specialize to fill those requirements better than SQLite. Many people bring up row stores (SQLite) vs column stores, but there are many other interesting differences and optimizations to be made, so I can see how SQLite may be leaving some niche unfilled.
I spend a lot of time thinking about how to make development easier, or at least less error prone.

Every once in a while I have a moment of clarity.

I remember that the other part of our job is extracting requirements out of people who don't really understand computers, even the ones who are ostensibly paid to do so (and if we're honest, about 20% of our fellow programmers). The more you talk to them the more you realize they don't really understand themselves either. which is why shadowing works.

If building the software gets too easy, we'll just spend all of our time doing the gathering part of the job.

And then I will do just about anything to forget that thought and go back to thinking about less horrific concepts.
Thank you, that really resonated with me (and made me move Sapiens up a bit on my reading list).
Let's make an analogy. To drive a car one needs to "know what they are doing" to the point that driving licenses are mandatory. Let's consider a common accident type: a collision because you turn but your directional lights remain off.

If it happens because the driver just forgot to signal, it's a mistake and it's hard to blame the car.
It's like knowing what transaction isolation levels can be used, but asking for the wrong one or trusting a random default.

On the other hand, if the directional lights remain off despite pulling the lever because the car is in a probably illegal power-saving mode, activated by turning the headlights off, and the driver should have reactivated directional lights with an ambiguously named item in the depths of some options menu, blaming the accident on user error would be very partisan: it's the car that doesn't know what it's doing.
It's like figuring out the correct transaction isolation level according to DBMS documentation, asking for it, and expecting it is actually used.
I think it's absolutely true that remote means less solidarity and connection between workers. Also hiring international remote workers are usually done on consulting basis, which less regulatory protections. I certainly see a world where software engineers become more fungible, and with the reduced messiness of human interactions, managers will be ruthless.

There are also some interesting arbitrage opportunities. For example, American companies would want to hire from countries with socialized medicine so that they don't pay for health benefits.

It could be more efficient, and it could lead to reduced poverty in some places in the world, but on net I don't think it's a desirable.

Ironically, the people who champion remote work the most do it from the perspective of the benefit to the worker. But as this essay suggests, and I agree, if you play it out, it will work out to the benefits of the companies and executives.

To be clear I'm not against remote, and could see the benefit to everyone, but it's naive not to play it through and think of the second-order effects of a fully remote industry.
I have a few counterpoints against your first sentence:

0. Tourism isn't a cure for ignorance, but it helps in widening worldview and experiencing how other people live and see. However, today it is mostly about having some time away from your residence/work.

1. Tourists are a small though non-negligible part of humanity as a whole

2. A large part of the people who have traveled as tourists have traveled to tourist spots, places that are developed to cater to the _tourists_ and hence aren't an authentic representation of the local population.

I do agree with your second sentence.
Git already is p2p. The whole centralized-git-through-github-or-whatnot is a fairly recent invention. Originally you'd pull directly from other developers repositories. The role of PR was fulfilled by emailing patchsets around.

All github does is provide convenience. If you want to use github in a peer-to-peer fashion all the tools are already there.
How to Run Dockers on CI
Blocking Pinterest results in image search was my first thought with this extension. That’s disappointing if it doesn’t, will test myself now.
I understand their concern; however I don't agree that the remedy mentioned in the article is the only path.

Knowing a sample is rendered invalid by mishandling or age might be accomplished by packaging an indicator with it which reacts when exposed to extreme temperatures and/or a chemical timer once packed.

The samples could also be delivered via drop-off to collection stations at hub facilities (E.G. medical clinics or hospitals) and stored in controlled environments for the rest of the process.
So the categorization of toxins vs. nutrients is just "bio-active molecules which are either detrimental or beneficial" to the organism?

Or do nutrients always have to transfer solar energy as some post above alludes to? Vitamins functionally support the organism without delivering energy - but they are considered as nutrients too.

Or are we going to include the criticality of its absence? The absence of vitamin C causes scurvy. The absence of caffeine merely means losing luxury benefits "on top of" what we strictly need.

In that way and as the benefits seem to outweigh the negatives, one could definitely argue that caffeine is a nutrient.
The background about these posters:

https://www.roche.com/sustainability/philanthropy/science_ed...

The book (2012):

https://www.amazon.com/Biochemical-Pathways-Biochemistry-Mol...

From the the accompanying text of the paper posters (all emphasis mine), it can be seen that the paper posters showed just a convenient selection of all the relevant knowledge:

"In the wall chart “Biochemical Pathways” the following principles were
applied:"

"The selection of reactions has to be made arbitrarily. Of course, no
discussion is necessary about e. g. glycolysis, protein biosynthesis and
other central reactions. Peripheral reaction pathways are preferably
selected if they are of high interest in biochemical, medical or biological
research (receptors, vitamins, antibiotics, compounds of importance in
regulation etc.), if they are of interest in medicine (e.g. blood
coagulation, complement system), if they lead to important end
products (e.g. microbiological fermentations) or if they enable
comparison of phylogenetic development (anaerobic/aerobic respiration or photosynthesis in various species).

Some indication on the degree of selection can be taken from the fact
that in the present “Pathways” about 1000 enzymes are shown, while
the 1984 “Enzyme Nomenclature” with its 2 supplements names 2859
enzymes. Estimations of the number of proteins (with and without
enzymatic activity) in a single mammalian cell are in the order of
magnitude of 30000."

"e) In general, we desisted from showing detailed reaction mechanisms.
Only in cases where discrete steps (e. g. in multi-enzyme systems) are
involved or well-characterized intermediates exist, single steps are
given. The same holds true for receptor-activation steps etc.

f) The interrelationships of metabolic pathways cause the biggest
technical problem of graphical representation. Since many compounds
take part in various pathways, one would obtain a “spider web” of lines
criss-crossing the whole chart. In order to avoid this, one has to “cut”
connections. The respective compounds, which reoccur in other places
of the chart, are written here in sharp-edged boxes."
Dolphin equivalent of a trainspotter. Doing it for food would be objectively intelligent.
Tourism can be educational, it's just destroyed by the modern life behavior e.g. social media addiction. Most people now compete on who has done the most trips in their lives, enjoyed the best cocktail in an exotic beach and posted the most perfect photo from the most iconic touristic destination. But you still can visit destinations to learn their history and blend with locals which no book can teach you.
NASA uses new Senator armored vehicles to support historic mission to ISS
Some quick Googling says that Phoenix metro is about 5M people.

Meanwhile, the bay area is the #1 highest COL in the continental U.S. Phoenix is ~#29.

If the argument is that tech requires a big city, I think Phoenix qualifies. If this is a hangup for you, consider Philadelphia: 5-7 M people, #21 COL.

It is obvious to me that population size is not why tech giants gravitate to SF or Seattle. (I'm confident that the high COL is also not the reason.)

Tucking 1000 employees into Houston and 1000 into Charlotte and 1000 into Toronto, then saving $200,000,000 per year seems very attractive to me. And if relocating 3000 makes sense, why not 10000?

There's obviously enough good reasons that they haven't done it. But from my seat in the balcony of the ignorant it seems awfully strange from an industry that prides itself on disrupting stale thinking.
Coronavirus patients not infectious after 11 days, say experts
they really should just start it up again. i'm sure there's many who would love to get off the chinese service
I never understood slack and why it got so populair.
DK?
Somewhere warm and safe. Singapore or Taiwan would be my best picks.

Too bad HK left that club, otherwise I'd also consider it.
How do your parse this sentence: The old man the boat
Yeah I haven't actually used it until 3.6.9 where it turned into its current final form. What is confusing about asyncio and how does curio solve that problem?
I agree with everything you've said, but I'd like to add a couple of counterpoints.

(1) The FDA is currently allowing some testing to continue despite the fact that they know the results are not fully accurate.

https://www.fda.gov/news-events/press-announcements/coronavi...

(2) It's unlikely the company was willingly not complying with the FDA and common sense here would dictate a formal warning first.