skysight-inc/HackerNews huggingface dataset:
That's helpful information.

I am my own ideal customer. If I were to start with individual custom items, they would be for me.

I have a medical condition and I hate the Sluts R Us vibe of so much of women's clothing and blah blah blah. I dream of doing this so I can stop schlepping around in men's t-shirts and men's sweat pants, basically.
Do you want me to seriously comment to what you just wrote? Similar to your other comment dismissing all types of intolerable pain from whatever illness. Seems fanatic like.
Are you saying that Facebook shouldn't be allowed to own any product that can be shared on a competitors platform? Seems kinda ridiculous.
This is exactly it and it’s becoming more and more common.

I have noticed that the password field is just hidden on some sites (as opposed to added or on the next page) and lastpass manages to fill it so once the JavaScript reveals the field it’s ready to hit submit.

It would be nice if this could be somehow standardised.
You've got it exactly right. It's something you need someone else's help with, and ideally you can just go ask them for help.
Google Drive Desktop – A cross-platform Google Drive desktop app made w Electron
Interesting article, but it could have done a better job of explaining the chemistry.

Remdesivir is a prodrug, meaning it must be metabolized (chemically processed) in the body to the active form. Think of it like this:

R-OPX -> R-OH -> R-OPPP

where OPPP is the triphosphate and X is the thing the body hacks off. R-OPPP is the active form of Remdesivir. Your body must perform the net reaction R-OPX -> R-OPPP before it can use the drug.

GS-441524 is R-OH in the above equation.

X is non-trivial to build and install, and it looks like it required a lot of work.

But as these things often happen, nature doesn't give e hoot about the medicinal chemist's net-o hypothesis (R-OPX is better) and does what it will do. It turns out the fancy targeting component PX isn't necessary for efficacy in animals. You get even better results using plain old R-OH.

Even better, R-OH is the starting material for R-OPX, so you save yourself some reactions to boot.

At this point a lesson pops up that gets forgotten time and again in drug discovery programs:

ALWAYS RUN THE CONTROL IN ANIMALS - RUN IT EARLY. NO EXCEPTIONS AND NO EXCUSES!

Also, there is enormous resistance to running the control, because of course it can't work - it's the control and doesn't conform to the neat-o hypothesis.

In this case, the control is R-OH. It was run, but not early enough it seems to prevent the R-OPX train from leaving the station. Once a team starts running with a compound it can be very difficult to pull them back.

Now, this is just speculation taking the article as gospel. It's almost impossible to know for sure what really happens inside drug companies because the trade secret/IP protection culture is so ingrained. Not only that, but I could be misinterpreting the facts presented in the article.

Of course, none of this addresses the main problem with Remdesivir: it can't be orally dosed. You need to get injected multiple times. And that's probably going to be in a clinic, and done by people wearing full PPE. An oral drug would allow you to buy pills and convalesce at home, conserving valuable hospital resources.

As an aside, you typically use a prodrug because you think it will lead to better drug properties than the parent compound. An interesting example is the case of Claritin/Clarinex. The former is the prodrug form of the latter. It turns out the latter is at least as good if not better than the prodrug. Another case of not running the control early, I suspect.
"Streaming and seeking are antithetical"

I disagree, for a library creating zip files. It's the logical way to do it. Otherwise, you're slurping potentially big files into memory, or making un-needed copies. I've also written zip library code.
It's a combination of popularity, forced usage, organic growth, and maturity.

If every single developer ever had to write Java we would see the same complaints.

* A ridiculous amount of dependencies and tooling.

* As many competing ways to architect programs as there are Java developers.

* Lots of warts and quirks due to design missteps in hindsight. Ignored by the people who love it but grating to the people who don't.

* As many "the good parts" as there are Java developers.

* Everyone complaining about Spring like they do React.

For most languages if you don't like it you don't use it. But with JS (just like Java in the 90's and 00's) even if you don't vibe with JS it's completely unavoidable.
> It would be so much more sensible to tap the user on the shoulder after the delivery to ask them for their tip.

That would be as problematic as what you described.
Personally I've lumped procedural and OOP together into a single concept. Put differently, I consider OOP as a strict successor to procedural. Both are about side-effects and state, OOP just gives you smarter tools for encapsulating and managing that state. FP lets you eliminate some state altogether. My personal philosophy is to eliminate as much state as you can, and then to smartly manage what's left.
Maybe I'm lost here but why is this a good thing? and what this is providing for the consumer. I am not harmed by Google price fixing (as far as I know) because I pay them exactly $0, nor do I want to see the days of the 90's again, when you needed a 'metacrawler' to search a bunch of search engines. Now if we were talking about my ISP, for which I have exactly 2 choices and both of them collude to increase my bill, then we'd be talking.
Sure. But there's an enormous amount of money flowing there, far more than in a tiny investment fund, so it's still a potential vulnerability. The US Treasury and the US Federal Reserve do manage actual assets, and again at enormous scale.
I still have a soft spot for coffeescript, I think it's a very nice language to write. I don't use it simply because no one else at my company does. But at this point, like others have said, JS is much better than it used to be. You have the arrow functions and classes from coffeescript, and honestly, those were probably the strongest features. Although it can probably forever hold the lack of semicolons the javascript's head.
I’ve seen this referred to as “satisfying your inner Linnaeus“ and have spent way too much time in that weird place myself.
It's true. It's ironic that he proved the rule by proving that double digit millionaires too can effectively be locked out of the legal system by those with greater financial might. After all, are you really justifying the illegitimacy of the system if all you accomplish is merely swapping the places of who is destroyed?
No, I am saying that them retroactively buying it without warning and getting access to the historical data, which users and developers did not intend to give to Facebook, is the off part.

If Facebook bought this or developed it themselves and then these companies integrated Giphy, it's obviously very different. Basically this implies that any data you give to any third party can then basically be bought by your competition. I think legal language that prevents this would likely be a net good thing. I of course realize it's fair game, but that seems like a great way to discourage the use of any third parties generally.

The acquisition itself is very valid from a product standpoint, but I suspect a big reason for the buy was that data on competitors as Facebook claws back against pressure from rising platforms. I would bet a good deal of money this will be used to inform future acquisitions and fuel the black hole of Facebook acquisitions and squashing of any competitors.
Google consistently makes headlines for culture war stuff from the blue side, it's the perfect foil for Trump.

It doesn't matter if they're biasing search results or not, that's complicated anyways, highly visible culture war stuff is what his audience is primed for.
Although that 'open email system' isn't as open in practice, since most of the big providers aren't going to accept your email if you set up your own sender.
not disclosing a financial conflict of interest is a mayor breach in how to conduct science, and there is exactly zero clickbait let alone conspiracy theories here.
I believe it's in both Oxford and Merriam-Webster.
So I agree that people have a fixation on "participation trophies" but the problem it attempts to address, essentially the featherbedding of education is a serious one.

In response to your question, about the stupid ribbon, it probably won't but that's the point. Everyone got a freaking ribbon, everyone got a ribbon in third grade, and fourth grade, and so when someone is actually exceptional how do you then distinguish them, you can't. It's not that the ribbon changed anything because you got it, it's because everyone got it that made it worthless.

Suddenly everyone can prove to everyone how smart they are, meanwhile those that are actually exceptional in an area without an easily defined winners and loser bracket can never be recognized. This leads quickly to a situation where my ignorance is as good as your facts because we are all can be "right in our own way."

The result leads to a distortion of facts a society that can agree on basic reality and everything being run by conmen and manipulators because they realized early on that was the only way to get ahead. Starting to sound familiar?
Does anyone know how to pronounce RaTG13 ? I've been saying "Rat Gee Thirteen".
It's a classical pull signal from a VC. While the valuation is on a 100 million they paid $10 million in primary capital and at least $2 million in secondary shares. But the amount of attention this generates is enormous. Everybody and their grandmother with a startup is going to apply to A16Z.

The opportunities generated from that is worth 10 million at least. It is just a better mouse trap in an economy bracing for the impact of a recession.

VC do not deploy marketing resources to normal channels they signal value through deal channels that do not make sense to other people. It is effective because even on the channel of a competing VC we are talking about A16Z.
*** You can just use three asterisks. ***

* You can just use three asterisks. *

Unfortunately you need something after them though. ***

Unfortunately you need something after them though.
> The training data could also be considered source.

That makes me wonder about something: would it be less computationally intensive to prove that a trained net is the result of some training data than the training procedure? A lot less? Can it be proven that there is no backdoor (supplemental training data altering the results)?

I suspect you could prove rather cheaply that the trained net weight indeed correspond to a local minima for the training data. However, there is no telling that this is the best minima that could be achieved, nor that the provided training dataset is enough to obrain that result.
> Boeing has a serious lack of competition. Their only meaningful competitor is Airbus and that's a foreign company. They have no domestic competition at all, which is inherently problematic, especially for a critical industry like that.

This isn't due to monopolistic behavior; the McDonnell Douglas company, the last big American competitor to Boeing, would probably have ceased to be a going concern had the merger not happened. Modern aircraft cost billions and billions of dollars to develop; Bombardier just threw in the towel and sold to Airbus, and Embraer almost did the same with Boeing were it not for COVID. There are only so many aircraft manufacturers with the resources to invest in development of brand new commerical aircraft.
This isn't the answer I wanted, but it's a good answer. Thank you
Before I ever dabbled in what was called "object-oriented" languages, I was happy enough to

<include stdio.h>
...
FILE myfile;

Isn't myfile really an object?
A few tips:

Lots of hackers are introverts. They are wired differently from founders and ceos (who have gravitated towards a life full of constant interactions with people). Hackers don't mind being "in the zone" for hours at a time to work on a problem. Sometimes this means coding, but sometimes this just means having enough quiet time to just sit an think while they turn a problem over in their mind. This is required.

Another side to the introvert thing -- I believe "open plan seating" is a fundamental disconnect between extroverted decision-makers and introverted knowledge workers. It is not surprising to me that productivity has skyrocketed for problem-solvers working from home.

Another tip is to ask "what do you think?" then listen. Then wait even longer and listen some more. The absolute best business people I've worked with were masters of this. The worst would already have made decisions and questions were just checkboxes.

(this works everywhere in life, but is particularly relevant to the really smart people at the top of the tech tree)

also, hacker doesn't mean criminals who break into computers. Go with the original meaning (well, the one after carriage driver)

reading:

https://stallman.org/articles/on-hacking.html
Well, we're not discussing creating zip files where seeking is an option, we're discussing streaming in the context of the attached link which uses it concretely in terms of writing to a network.
Bach Upside Down: human/computer inversions of the Goldberg Variations
The authorities don't want it to succeed. They want a bunch of "I told you so's" to justify shutting it down
If you indent it two spaces, I think that should solve that problem:

*(`^#.$`), and others will interpret it as you have (`^#.?\n`)*

(Not sure where you intended those asterisks. I made my best inference.)
As someone who was shamed out of using Perl, I can confirm that "more concise" isn't actually desirable at a certain point. Devs don't like verbose, but they also don't like obtuse. CoffeeScript is obtuse. To borrow a complaint from 10 years ago, it's like executable line noise.
Doesn't this then threaten to destroy the dynamic of our physical spaces at the expense of virtual optimization?
Google only has one Developer Advocate working on Chrome Extensions
Please stop spreading misinformation about a serious topic.

"Currently there is no evidence of food or food packaging being associated with transmission of COVID-19.”

https://www.fda.gov/food/food-safety-during-emergencies/food...
The plagues of Europe didn’t stay in Europe. They eventually came to the Americas where they wiped out most of the native populations.

If globally connected people are so bad, then why has the Catholic Church been so big on extending their reach across the globe throughout history. Why spread the gospel?

This just seems like a low blow. I’m not even sure what question is unanswered here. The vagueness of this article makes it hard to have a conversation with.
Websockets certainly has simple heartbeats. It has Ping and Pong frames defined in the spec: https://html.spec.whatwg.org/multipage/web-sockets.html#ping...

The libraries I use tend not to enable it by default, but they are generally implemented.
Yep terrible product that made the internet worse. Wish Google bought them so we would know it will be shut down.
All my favorite games that I'd been eagerly awaiting release around April have all been delayed - Cyberpunk 2077, Watch Dogs Legion, even the second Vampire: Bloodlines installment!

Still, it's probably a good thing for my work productivity...
Yeah, they're definitely lacking in innovative products lately. But they're still spending a fair bit on incremental innovation. The iPhone is still the phone to beat in terms of camera quality, and they're making other improvements like whatever their face-radar thing is. This means that the other phone players have to keep innovating too, and can't just settle down and hoover up cash, so I'm ok with it.
You liked flash programming??
People who buy games more frequently are a bigger part of the market because they buy more games.
"Turns out I'm not the only one who listen to podcasts while writing code"

I doubt this person is producing good code or learning anything from the podcast.
You need that in provisioned in case of overload, too, right?
This is the most informative article that I read today. No hype, no story, just a plain list of engineering choices, some explanations, and a very useful list of tools.
Can We Save Facebook?
They'd me much better off having them open source YouTube and/or Gmail. I don't really think Google as a whole is an evil corporation, and there are a lot worse companies out there with a clear monopoly.
The charm of /giphy is that it returns seemingly random nonsensical results from whatever you type in.
Might be based on user preference influencing weighting for search results. I've know I've personally done all I can to block Fox News and other low quality sources from Google News.
That explains our disagreement. I read "large zip archives" and assumed there was at least an intermediate file created.
> Also, both Animal Crossing and Stardew Valley are much deeper and richer games (i.e. not “casual”) than your latest graphics whore zombie shooter.

I'm not sure how I feel about this statement in general, but I find it funny that the actual latest "graphics whore zombie shooter" happens to be Doom Eternal, which has its own depth and richness that elevates it above the mainstream FPS games you're referring to.
technically the chemical manufacturing lines are already there - there is an active gray market for GS-441524 produced in China for cat FIP.
Moot point, everything will be wireless in 10 years with 5G speeds and the expense of laying fiber.
I hope Facebook would get slapped with an anti-competitive behavior suit if they tried to pull that one.
This is not an accident. It’s the system working as designed. Steve Bannon famously described his agenda as the “deconstruction of the administrative state.” It’s pointless to argue about the chicken or the egg of how the CDC became crippled. The administration does not want it to succeed.
There's a good talk here from Uncle Bob who helped popularise the solid principles, about what OOP is, and isn't

https://youtu.be/QHnLmvDxGTY

Towards the end of the talk note of the stickers on his laptop
Most people use Chrome already so they don't see how aggressive Google popup spams anyone not using it. Meanwhile, Microsoft tries a subtle reminder about Edge, and there's a media ruckus about it for days.
I don't think there is anything fundamental about cryptocurrency that would make them entirely immune to theft.

You can both believe that the blockchain is working as intended and that the coins were stolen.
That interview was bad. They're trying to make you feel bad for the Instagram founders because they were too stupid to realize that after you _sell_ your company you don't own it anymore. Also, per that interview, Instagram only became sustainable under Facebook.

Hard to feel bad about it.
The problem is most browsers don't have an easy way to add custom styles any more.

Desktop Safari does, surprisingly, and I use it there.

Firefox removed that feature.

There are extensions, but browser extensions are a massive security hole so I don't use any that aren't too-big-to-be-corrupted.
Economics is the most cliquish field by far. There are basically five universities that matter, they get all the citations, no matter how dumb their research is. It's just fashion (and grant money). Everybody else desperately tries to win favor with the elite and just replicates their worst tendencies. In a real science you get citations all over the place. In economics all the citations are Harvard/Yale/Princeton/Stanford/Chicago. Somehow it's impossible that anybody in South Dakota or Missouri could ever do anything worthwile, I wonder how that's possible. The cliquish gives them license to support whatever insane ideas the Jeffrey Epsteins of the world prefer.
This is such a ridiculous statement.

Cable companies have taken billion in federal subsidies, lied about universal deployment and speeds, and unless there is local competition have taken customers to the cleaners, forced the purchase of bundled channel packages, charged rentals for modems they were not renting (I should know - I called in every month to have charge removed) etc.

I can think of a long list of other large / monopoly type companies that regular abuse consumers at far higher levels than google does.

Consumer spend on google is actually pretty small.
eh this just temporarily reinstates the prior tax code before the 2017 Tax act changes.

The 2017 law removed the ability to carry back net operating losses, only leaving carry forwards. We had carry backs for at least 3 decades.

The CARES Act temporarily reinstated carry backs. I think it is disingenuous to say thats a problem, when its more normal than anything else that has happened.

Regarding how it was sold for the "little guy", who cares? Like imagine being that naive not to notice that everything gets consensus in this country by catering to the constituents that can gain consensus. Consensus needs numbers, you don't sell a bill by saying "in this esoteric accounting standard that you will never encounter, we need to make a rule change regarding carrying losses to encourage growth ACT", you cater to things most people will encounter, and that the representatives of those people will relate to, and get phone calls and emails from their people about.

I take social cues from other people, so I can tell I feel differently, as in feel nothing, from this. But I think you should too.
Sure. We used webrtc, websockets and a signalling server which helps in discovering who is available on your local network. However, none of the calls or files ever go through the server.

We want to refine it a bit further before taking it opensource. :)
I don't disagree although the system philosophically, at it's core, has no concept of theft, of permission, or reversal. Keys = coins.
Extensions are also a huge security liability; I install very few of them these days
Fox News is by a large margin the #1 cable news network. If search results were weighted based on user preferences you’d expect it to show up more, not less.
For context (and also protip if you weren't aware), there's already precedent for user-defined CSS in HN. I don't remember if everyone has access to it, but there's a topcolor setting in your profile that sets the color of the top bar. Maybe that could be extended to include other CSS properties? I wouldn't mind having to write hex color codes...
> It's not clear what technical content this post has.

Indeed. The post is a big exercise in strawmanning (and of course ad hominem but I am willing to forgive it because it adds entertainment value). Andrew Gelman (a well-known statistics expert) dunks on some guy because he dared to defend a shitty graphic and "made a statistical error". Which is kind of unfair, because he didn't do any statistics. Of course when our brains see some curves they can't resist the temptation to do some statistics on their own, but bad dataviz is a different sin than bad statistics and should be treated as such.
That tweet was a totally unforced error. Like, there are a few people you might to not misrepresent in this space, and Kyle is one of them.
Something you run into when adding Typescript annotations to existing JS / libraries in the wild is when the signature turns out to be:

function transform(a: number | string): number | "" | false

And it's usually all by accident. And it works because in practice it's used with a `if (!transform(x))` check.

Static typing doesn't just tell you what's going on, but it also helps you keep your implementation honest with your intent. It's also why it's a good habit to annotate top-level functions instead of relying on their inference.