skysight-inc/HackerNews huggingface dataset:
> The amount of noise in human clinical data can defy belief if you haven’t seen it in person

I'm not surprised that patient compliance is a problem, but it still seems like an expensive burden to find patients physically near the clinical trials so they can come in to take the medication. It just seems like a logistical nightmare that software could help with.

Could you build an app that requires patients to record themselves taking their medication under whatever conditions they're supposed to? You might have to manually audit all of the recordings, but the number of people that still fail to comply might be offset but how many more patients you can include in the study. There might be a lot of other things you could verify remotely using wearable tech, e.g. heart rate now that Apple's EKG monitoring is FDA approved.

Great read, I'd like to see more "Chesterton's Fence" arguments for other highly regulated industries.
Ask HN: Does UX for internal tools need a re-brand?
It is to get investment in UX for internal tools, even where orgs will invest for consumer facing apps/tools/products. I've been watching Matthew Bird's excellent videos on Industrial Design, and the video on Efficiency [0] sparked this question.

What if UX was called Efficiency Design or something similar?

0. https://www.youtube.com/watch?v=z8MhAm-FwX4
> The New York times isn't seeking the name or address in their request, just some other metadata about each comment including the IP and user agent header.

The point of the person you're responding to is that the NYT doesn't need to seek names or addresses, because they're already public information. Anyone can go look up the docket and see them[1].

So, their argument I believe is that, given that the names and addresses of the filers of comments are already publicly available, what further privacy concern is there in releasing IP address information?

And there might be one. IP address & UA might further allow me to correlate the user's activity elsewhere; some comments didn't submit names or addresses — IIRC these were "required" but some people filled in the fields with things like "none".

There were also allegations that the names of some comments were falsified on comments not in favor of net neutrality. IP address information might lend evidence to or against those allegations.

[1]: https://www.fcc.gov/ecfs/search/filings?proceedings_name=17-...
> “ Remember that Wells Fargo is the 26th largest corporation in the world. They have plenty of money. They have lots of smart people (insert your "stupid banker" joke here) working for them. They have lots of highly-paid analysts that make these decisions. These are not spur-of-the-moment, panic-induced decisions.”

This is so comically untrue. Giant companies with forcefields of cash, lobbyists and corporate analysts make stupid panic-based decisions all the time. There are chaotic political battles, unilateral decisions made because one executive had a pouty fit over what another executive did, huge layoffs, price changes, project shutdowns, all based on emotions, political favors, vendettas, etc.

It’s the rule. The clean, well-supported decision that came from analysts with statistical rigor is the exception by far. The larger and more bureaucratic the company, the more extremely tilted towards politics it becomes.

These decisions are rarely punished by the market due to regulatory capture, bailouts, outright fraud, etc. which essentially occur continually for most large companies with no meaningful consequences, even when these acts are completely overt and public.
can you set a restart policy with just Docker?
I'm not speaking to what I consider "real time," I'm speaking to how it is commonly used as a phrase . But given that...

Yes people do say "real time playback" with respect to video. Generally, however, that is only noteworthy to call out when its unusual. Such as "real time 16k playback."
Is this potentially why children are less impacted? They have more recently had the MMR vaccine.
Web Sites as ‘Public Accommodation’ Under a Pandemic
Ubuntu is sending out "Mission critical" software as snaps: I think the biggest offender has been LXD, but I'm sure there's others.

That combined with Ubuntu forcing snaps as the main packaging method (i.e. you have to jump through various hoops to install .debs of snaps) is what a lot of the outrage about.

(Side note: Something about listing Docker as a packaging mechanism makes me uncomfortable. IMO Docker and containers in general are deployment tools, not packaging systems)
I've tried this multiple times, but in my experience, there just aren't that many restaurants that allow you to pay without giving a credit card number. That's a non-starter. Yes, I do give my credit card information to some companies, but only when I know said company would be devastated by a breach, and I keep it as limited as possible.
If you're looking for an alternative to Ubuntu but want to stick with a Debian-based distribution, I'll continue to recommend Debian testing.

It's a rolling release, so you don't have to stop what you're doing every 6 months - 3 years to install a huge update that changes the way everything works. It's more stable than the name would suggest, as long as you follow a few reasonable best-practices [1].

Software available on Debian testing is pretty up-to-date... If you're previously tried Debian stable but were put off by ancient packages, you won't see this in testing. Keep in mind that Debian testing (not stable) is upstream for Ubuntu's releases, so Debian testing's packages will be about as new as Ubuntu's packages on release day (but they're updated continuously, so they stay fresh).

I have personal systems running Debian testing or unstable that have been running continuously for 5-10 years without issues. They don't look or feel any different than systems I set up a few months ago.

[1] https://news.ycombinator.com/item?id=23044878
I think the issue is we expect Ubuntu to not only design features for common folk but also have an easy to use solution for the type of tech literate people that Linux attracts.

They have prioritized snaps but how have they made life easier for those of us running "mission critical" software?
The more urban an area is, the worse the public schools are. You seem to be providing even more of a reason to flee cities.
Ask HN: Should I just give up my ambition of being a decent security researcher?
Back in my high school days, I was your typical next door script kiddie. I knew x86 assembly and a few programming languages, was capable of hacking some crackmes, SQL injection and the like.

That's just to say I always had the mindset of breaking stuff. However, lack of resources and guidance, and just life in general, led to a different career path for me as an adult.

About 10 years later now, I have had a relatively successful career in software development – though I feel I have so so much to learn yet. I still don't feel like a "senior" dev, even though some would say I am.

My desire to "break" things has never diminished, however. I have fun doing various exploitation CTF challenges, (e.g. exploit.education), but that's where my hacking skills stop.

I would like to start working on "real" exploitation, like browser or kernel exploitation, but at this point I'm wondering whether that's the right thing to do. I know it's not too late to get started in the literal sense, but I feel like perhaps focusing on improving myself on the development side of things is a better use of my time.

Heck, maybe I've already made my decision subconsciously, and I'm hoping a bunch of internet strangers will approve that decision. Time is a finite resource, and I don't know what the best decision would be for me. I'm sure there's a lot of people who've been on the same situation before, so I'd appreciate your thoughts and experiences.
Please put the word "fake" back in the title.
Perhaps this bit:

While the analyses above suggest that SARS-CoV-2 may bind human ACE2 with high affinity, computational analyses predict that the interaction is not ideal7 and that the RBD sequence is different from those shown in SARS-CoV to be optimal for receptor binding7,11. Thus, the high-affinity binding of the SARS-CoV-2 spike protein to human ACE2 is most likely the result of natural selection on a human or human-like ACE2 that permits another optimal binding solution to arise. This is strong evidence that SARS-CoV-2 is not the product of purposeful manipulation.

But again, the poster clarified this only addresses the engineering of the virus, not the the other theories that center around lax precautions at the lab.

So, these threads do devolve into a predictable pattern, but I’m compelled to bring up instances where viruses escaped from Chinese labs before:

https://www.the-scientist.com/news-analysis/sars-escaped-bei...

I believe there were a few more instances too (not mentioned in the article).
A good CTO is at least involved in the pre-sales process if not the entire sales process of large deals. Especially when the product being sold was built by the CTO’s team. That’s been my experience anyways.
From a design standpoint I don't see effort from Flutter to look and feel native to iOS. Hamburger menus and details like the sharing icon might be great on Android, but it's unclear if they're familiar to iOS users. Personally I tried Flutter's demo app associated with their announcement, and basics like scrolling stuttered on the latest iPhone hardware.

https://developer.apple.com/videos/play/wwdc2017-802/?time=1...
What’s wrong with the windows one? It’s instant and it calculates things?!?
Perhaps it's possible to destroy the earth and still be nice on the Internet? The two aren't mutually exclusive..
Home directory encryption is a terrible security mode for single user laptops (an attacker with disk access can simply modify the unprotected root file system and exfiltrate data after the fact).
Whole disk encryption (and encrypted suspend to disk for bonus points) is simpler, more secure, and doesn’t break ssh (and all sorts of other things, like batch jobs).
> It's specific to company cultures, not Americans in general.

I think some cultures have an ingrained mistrust of the idea that some people are so far above others. Perhaps that attitude forces a false humility onto geniuses, but it works as a cultural inoculation against blowhards and pretend superheros. In the U.S., I think we have a complicated melange of different influences ranging from the New England protestant stereotype who would never tolerate such people to the South which I think cultivates an unfortunate craving for Great Man saviors (which can manifest on the small scale, like one engineer gathering a cabal of awed worshipers in an engineering organization, or on the national scale with politicians.) These are broad stereotypes, and I think cultural and geographic mixing in the U.S. makes accurate generalization impossible, but different people have different gut reactions to people who make implicit or explicit claims to greatness, and I think these gut reactions are culturally ingrained in childhood. Companies can cultivate a culture, but I don't think that will override whether a person responds to grandiose self-presentation with aversion or craving.
Is there any realistic expectation of anonymity when it comes to FCC comments?

They usually publish the names of people who commented don't they? I know mine was accessible.
Nope. We learn the material over (having been out of school for at least two decades) from the home school material, and then teach it.

If you don’t have patience, but also can’t afford private education of some sort and have to resort to broken public institutions, there's not much hope (imho). Patience is cheap (comparatively speaking).

I've learned how to weld, sail, wrench on diesel engines and my Teslas, perform wilderness EMT procedures, woodwork, and build houses/perform large scale home improvement on my own. K-12 is a cake walk. Don't doubt your vibe, you're a fellow human and you can do it too.
Show HN: Small Lisp in Kotlin
Building a SaaS in Public: Bookmark App – Day 1(ish)
there are alternatives to believing that the value of the entire housing market is going to drop:

1. your last N years of work/credit history are currently less predictive about future income/repayment ability than banks would like. regardless of who you are.

2. even if the same amount of money continues to chase the housing market, there is (as some other comments mention) at least a little bit of a reason to believe that the money might want to move to different geographic areas. if you don't know what that change will look like, your ability to predict future home values is reduced.
As apposed to Yung Venuz. Paging Vlambeer.
Cities normally have advantages that offset those drawbacks: employers but also amenities, people to meet, events to attend. You trade off the quality of your private space for a richer public realm. But there is no public realm anymore. The biggest cities are as boring as the smallest towns.
One reason I heard, but have not verified, is that their content managements systems don't support links.

Pathetic, right?
The genetic “architecture” doesn’t look human-made. Here’s a popular science summary for people who don’t have the training to read the paper (which is most people, for any science paper as they are written for domain experts and nobody is a domain expert in every field):

https://www.sciencedaily.com/releases/2020/03/200317175442.h...
There is. Don’t install Ubuntu. Use Debian.
Every executive in a company at a minimum should have a general understanding of other functions. If the CTO knows what selling looks like, then the CTO can better assist the sales team. Likewise, if the sales team understands how software engineering works (at a very high level), they'll generally understand that "getting a very complicated feature RIGHT NOW for one deal" is ... not realistic.

etc.
Show HN: Wayfind Maps – For Navigating Apartment Complexes in DFW
We created this website in order to help door to door delivery people in the Dallas area. The website uses a MERN stack and we host about 500 apartment complex site maps.

Here are some example pages:

This is a high quality map of 'Cool Springs'
https://www.wayfindmaps.com/aptpage/5e963dcec120e83050f3eb35

This complex gave us a map, but it's of questionable quality
https://www.wayfindmaps.com/aptpage/5e963dcec120e83050f3eb3e

Here's an example of a complex that doesn't have map data yet:
https://www.wayfindmaps.com/aptpage/5e963dcec120e83050f3ec36

Our strategy for map collection is to reach out to apartment complexes directly, and to take map submissions from users. We would very much like your feedback.
This is amazing but does it adhere to reddit's policies?

I believe this would be an awesome SAAS product, you should offer some paid hosting & setup like Mautic does https://www.mautic.org/.

Best of luck!
It's an aesthetic complaint. It has the word "feels" right in it. What do you expect?

With that said, as someone who hasn't programmed in Forth-likes but has read about them, I can guess at a more precise complaint: stack manipulation operations like dup, swap, roll, et al are pure noise relative to my business logic. They're implementation details constantly interfering with my intent. And yes, I'm sure if I find just the right factorization into tiny words I could avoid most of the explicit stack twiddling, but is that really a good use of time relative to writing in C? Or figuring out how to design a better language? Doubtful.
The difficulty with things like credit scores is that they are a trailing measure; all consumers are suddenly a much bigger risk than they were in January, even if they've still got a great credit score (based on history). WF is probably concerned that they can't appropriately price the risk, or that the price they'd be comfortable with would be too high to bother (for publicity, for actual business volume, or some other regulatory limit on absolute interest rates).
What if your goal is to bring Linux to the masses?
yes that would also work! I forgot about the `-c` argument for uniq.
If you want something that you can host yourself, Nextcloud might be worth a look.

https://en.m.wikipedia.org/wiki/Nextcloud
And decompression is typically very fast. What I don’t understand is why they’re not using something like zstd if they care about speed. It’s a supported compression algo for squashfs, but still they insist on using a single threaded compression (xz iirc?) algo.
No mention of Devuan, a fork of Debian for the sole purpose of removing systemd (and they're also not a fan of dbus, for reasons that escape me).
The Guide to CSS Flex
website layout tutorial
Yes and no. Sending a chip to one foundry to do the first few layers and taking the chip to a second or third foundry has been done at Stanford as a proof of concept to mitigate against this attack. Other attacks are still possible but likelihood of success starts dropping off a cliff.

Foundries will generally use different “standard cells” (ratio of dopant in silicon to make the basic building blocks of your “P’s” and your “N’s”) so this is actually a big ask and not trivially supported out of the gate.

This in turn can be worked around by double welling ones designs but it becomes a yak shave real fast.

With OpenTitan compiling on open synthesis tools we’re about 3 of 5 steps towards an open silicon root of trust.
This is actually a great idea. I walked away from five underwater mortgages in 2012. I paid $1000 on a second loan during a short sale and paid 1/3 of the difference between what I owed on one after the sale. The other three I paid nothing.

Three years to the day after the last short sale, we bought a brand new build in a much better area of the city with 5% down on a custom build. No bankruptcy required.
Nvidia’s chief scientist developed a low-cost, open-source ventilator
People are downvoting you, but this is actually not a bad idea. People have been brainwashed into believing they should 1) forever be indebted and 2) always carry the burden of debt.

As the saying goes: If you owe the bank $100 that's your problem. If you owe the bank $100 million, that's the bank's problem.
As a long time (almost 20 years) fan of PTI on ESPN, I finally began listening to the Tony Kornheiser show, which is a daily podcast.

I like it very much - a mix of sports and pop cultural commentary and some very high profile guests (along with recurring guests on topics like film, food, etc.)

It's a bit diminished right now - only runs three days per week and, obviously, they are reaching a bit now with whatever sports or film commentary they might have ...
it must be evil because Microsoft did it. Weird that they copied everything else Windows did and people didn't mind.

There's way more evil things about Windows, like click to raise and menu bars.
I agree. Individuals might not be able to afford land. But large corporations will definitely be able and more than willing to.
The point is whether canned responses came from a "organic" groundswell of concerned citizen or a handful of astroturfers.
Is there any stable way to go Ubuntu -> Debian?

I don't want testing. Stable is fine.

I find each version of Ubuntu worse than the previous. It's change for the sake of change, and as in this case, something really thoughtful like .deb gets replaced with something which appears slapped together poorly.

I just want a stable, working system, and Ubuntu seems to no longer be the way to have that.
The customer is always right. Say it with me.
Into the general economic uncertainty? Sure, for the right price. I think it's possible at this point to make reasonable predictions about how bad things are likely to get. Their action seems to imply they think the real estate market is particularly uncertain - that they can't put a useful lower bound on housing prices.
It’s more likely a recognition of adverse selection in anyone seeking a loan now than a particular opinion about housing values.

Under basically no point does Wells Fargo want to foreclose on a house. They will get pennies on the dollar for it independent of macro price differences.

So in analyzing risks a 10% increase in foreclosures is going to weigh dramatically more than a 10% decrease in home values.
> Browsing the Snap Store sucks

Yeah a lot of the software you see in the store is legacy software that seems to be stuck on an older version. Also many of the items are lacking a screenshot and a comprehensive description of what the software does. I find myself using the store to discover software and then go to the software's official website (usually on Github) and install it the oldskool way by doing:

./software.deb
I've just checked that my old LG flip phone still works, perhaps I'll have to start using it.
The massive and steady increase in home value would suggest a bubble, no?
That would be plausible under the hypothesis.
Systemd gives you less control. I used to pipe stderr to email, cant do that with sustemd. The journaling system is very slow compared to plain text files. Systemd overwrite mounts made by ip netns. Network settings is complicated with systemd. Not all bad though, setting up services is easy, and it has never failed to start a service for me so far, and it do start services in the correct order, which is all it should do imho.
I was surprised by the counts[$1] = counts[$1] + 1, since I didn't think it would correctly coerce a non-existing value to a 0.
I think a big reason why Saudi Arabia and US are keeping oil prices low is because it’s a useful attack on Russia, Iran and Venezuela.

I don’t see why Venezuela say is worse than Colombia which is a far worse human rights offender.
Original paper: Napieralski, S., Buss H., Brantley S., Lee S., Xu, H. and Roden, E (2020). "Microbial chemolithotrophy mediates oxidative weathering of granitic bedrock." PNAS 116 (52) 26394-26401; DOI: 10.1073/pnas.1909970117.

PDF: https://www.pnas.org/content/pnas/116/52/26394.full.pdf?casa... (works, even though it seems like it shouldn't...)
The products back then were totally ridiculous. For example, 5/1 interest only loans with reverse amortization. What does that mean?

A normal adjustable-rate mortgage starts off with a fixed rate period, say 5 years. Then the remainder is a 25-year adjustable rate mortgage.

What these guys would do is sell a 5 year loan with a balloon payment at the end. The reasoning being that "hey the market is appreciating so fast right now, you'll refinance before the loan is over anyway."

Interest only loans mean that for the entire time of the loan, you're not paying any capital back, and will still owe the entire balance. So you're basically renting the property.

But wait, there's more! With reverse amortization, you could pay $1000 for a $2500/mo payment and the difference would be plopped onto your balance!

So people would buy a $300,000 house. Then at the end of the 5 year period they'd owe $400,000. Very common problem.

Unfortunately, as those started coming due, the banks were suspicious and would no longer lend people money so easily. And the requirements to get those crazy loans were pretty lax in the first place.

Brokers at the time were acting like loan sharks. And they had a like 6% incentive to do so. It was pretty out of hand on all sides of the deal. Plus there were numerous cable TV shows going on about how great it was to own a house, and tons of TV commercials talking about how easy it was to get a loan.

I mean even today, people are extremely pushy about buying houses.
yes, and the stupid thing is you get a second copy of the application, different version, different UI, seems very broken
Many options

https://repl.it/languages/go

https://github.com/d5/tengo

https://github.com/motemen/gore

Also you kinda don't need a repl as much with go (coming from a python background and constantly repl-dev-ing), especially with an IDE. Everything is so clear and type-safe there is little divide between the architecture in my mind and the code's behavior.